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Conserved domains on  [gi|768039199|ref|XP_011529655|]
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WD repeat-containing protein 44 isoform X1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 485-832 5.73e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 140.93  E-value: 5.73e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 485 HMGAVWTMKFSHCGRLLASAGQDNVVRIWalknafdyfnnmrmkyntegrvspspsqeslsssksDTDTGVCSGTdedpd 564
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVW------------------------------------DLETGELLRT----- 46

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 565 dknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCF-QHIDFVTAIAFHPrDDRYFLSGS 642
Cdd:cd00200   47 -------------LKGHTGPVRDVAASADgTYLASGSSDKTIRLWDLETGECVRTLtGHTSYVSSVAFSP-DGRILSSSS 112

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 643 LDGKLRLWNIPDKKVALwnEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEhlkyhTQIHVRSTRGRNKVgrkITG 722
Cdd:cd00200  113 RDKTIKVWDVETGKCLT--TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR-----TGKCVATLTGHTGE---VNS 182

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 723 IEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKG---YVNSssqikASFSHDFTYLVSGSEDKYVYIWstyhDLSKFTS 799
Cdd:cd00200  183 VAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhenGVNS-----VAFSPDGYLLASGSEDGTIRVW----DLRTGEC 253

                        330       340       350
                 ....*....|....*....|....*....|...
gi 768039199 800 VRRdrndfwegIKAHNAVVTSAIFAPNPSLMLS 832
Cdd:cd00200  254 VQT--------LSGHTNSVTSLAWSPDGKRLAS 278
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 485-832 5.73e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 140.93  E-value: 5.73e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 485 HMGAVWTMKFSHCGRLLASAGQDNVVRIWalknafdyfnnmrmkyntegrvspspsqeslsssksDTDTGVCSGTdedpd 564
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVW------------------------------------DLETGELLRT----- 46

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 565 dknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCF-QHIDFVTAIAFHPrDDRYFLSGS 642
Cdd:cd00200   47 -------------LKGHTGPVRDVAASADgTYLASGSSDKTIRLWDLETGECVRTLtGHTSYVSSVAFSP-DGRILSSSS 112

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 643 LDGKLRLWNIPDKKVALwnEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEhlkyhTQIHVRSTRGRNKVgrkITG 722
Cdd:cd00200  113 RDKTIKVWDVETGKCLT--TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR-----TGKCVATLTGHTGE---VNS 182

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 723 IEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKG---YVNSssqikASFSHDFTYLVSGSEDKYVYIWstyhDLSKFTS 799
Cdd:cd00200  183 VAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhenGVNS-----VAFSPDGYLLASGSEDGTIRVW----DLRTGEC 253

                        330       340       350
                 ....*....|....*....|....*....|...
gi 768039199 800 VRRdrndfwegIKAHNAVVTSAIFAPNPSLMLS 832
Cdd:cd00200  254 VQT--------LSGHTNSVTSLAWSPDGKRLAS 278
WD40 COG2319
WD40 repeat [General function prediction only];
470-790 3.87e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.59  E-value: 3.87e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 470 YDFDQIKVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNVVRIWalknafdyfnnmrmkyntegrvspspsqeslsssks 549
Cdd:COG2319  147 WDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDDGTVRLW------------------------------------ 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 550 DTDTGVCSGTdedpddknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTA 627
Cdd:COG2319  190 DLATGKLLRT------------------LTGHTGAVRSVAFSPDgKLLASGSADGTVRLWDLATGKLLRTLTgHSGSVRS 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 628 IAFHPrDDRYFLSGSLDGKLRLWNIPDKKvaLWNEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEhlkyhTQIHV 707
Cdd:COG2319  252 VAFSP-DGRLLASGSADGTVRLWDLATGE--LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-----TGKLL 323

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 708 RSTRGRNkvgRKITGIEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKG---YVNSssqikASFSHDFTYLVSGSEDKY 784
Cdd:COG2319  324 RTLTGHT---GAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGhtgAVTS-----VAFSPDGRTLASGSADGT 395


                 ....*.
gi 768039199 785 VYIWST 790
Cdd:COG2319  396 VRLWDL 401
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 613-651 1.48e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 1.48e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 768039199   613 RECLCCFQ-HIDFVTAIAFHPrDDRYFLSGSLDGKLRLWN 651
Cdd:smart00320   2 GELLKTLKgHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
613-651 7.67e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 7.67e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 768039199  613 RECLCCFQ-HIDFVTAIAFHPrDDRYFLSGSLDGKLRLWN 651
Cdd:pfam00400   1 GKLLKTLEgHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 571-659 2.41e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.02  E-value: 2.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 571 RQRPFCKYKGHTADLLDLSWSKNY--FLLSSSMDKTVRLWHISR--------RECLCCFQ-HIDFVTAIAFHPRDDRYFL 639
Cdd:PTZ00420  63 RKPPVIKLKGHTSSILDLQFNPCFseILASGSEDLTIRVWEIPHndesvkeiKDPQCILKgHKKKISIIDWNPMNYYIMC 142

                         90       100
                 ....*....|....*....|
gi 768039199 640 SGSLDGKLRLWNIPDKKVAL 659
Cdd:PTZ00420 143 SSGFDSFVNIWDIENEKRAF 162
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 485-832 5.73e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 140.93  E-value: 5.73e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 485 HMGAVWTMKFSHCGRLLASAGQDNVVRIWalknafdyfnnmrmkyntegrvspspsqeslsssksDTDTGVCSGTdedpd 564
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVW------------------------------------DLETGELLRT----- 46

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 565 dknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCF-QHIDFVTAIAFHPrDDRYFLSGS 642
Cdd:cd00200   47 -------------LKGHTGPVRDVAASADgTYLASGSSDKTIRLWDLETGECVRTLtGHTSYVSSVAFSP-DGRILSSSS 112

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 643 LDGKLRLWNIPDKKVALwnEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEhlkyhTQIHVRSTRGRNKVgrkITG 722
Cdd:cd00200  113 RDKTIKVWDVETGKCLT--TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR-----TGKCVATLTGHTGE---VNS 182

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 723 IEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKG---YVNSssqikASFSHDFTYLVSGSEDKYVYIWstyhDLSKFTS 799
Cdd:cd00200  183 VAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhenGVNS-----VAFSPDGYLLASGSEDGTIRVW----DLRTGEC 253

                        330       340       350
                 ....*....|....*....|....*....|...
gi 768039199 800 VRRdrndfwegIKAHNAVVTSAIFAPNPSLMLS 832
Cdd:cd00200  254 VQT--------LSGHTNSVTSLAWSPDGKRLAS 278
WD40 COG2319
WD40 repeat [General function prediction only];
470-790 3.87e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.59  E-value: 3.87e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 470 YDFDQIKVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNVVRIWalknafdyfnnmrmkyntegrvspspsqeslsssks 549
Cdd:COG2319  147 WDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDDGTVRLW------------------------------------ 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 550 DTDTGVCSGTdedpddknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTA 627
Cdd:COG2319  190 DLATGKLLRT------------------LTGHTGAVRSVAFSPDgKLLASGSADGTVRLWDLATGKLLRTLTgHSGSVRS 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 628 IAFHPrDDRYFLSGSLDGKLRLWNIPDKKvaLWNEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEhlkyhTQIHV 707
Cdd:COG2319  252 VAFSP-DGRLLASGSADGTVRLWDLATGE--LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-----TGKLL 323

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 708 RSTRGRNkvgRKITGIEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKG---YVNSssqikASFSHDFTYLVSGSEDKY 784
Cdd:COG2319  324 RTLTGHT---GAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGhtgAVTS-----VAFSPDGRTLASGSADGT 395


                 ....*.
gi 768039199 785 VYIWST 790
Cdd:COG2319  396 VRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
470-832 7.20e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 140.82  E-value: 7.20e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 470 YDFDQIKVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNVVRIWalknafdyfnnmrmkyntegrvspspsqeslsssks 549
Cdd:COG2319  105 WDLATGLLLRTLTG-HTGAVRSVAFSPDGKTLASGSADGTVRLW------------------------------------ 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 550 DTDTGVCSGTdedpddknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTA 627
Cdd:COG2319  148 DLATGKLLRT------------------LTGHSGAVTSVAFSPDgKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRS 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 628 IAFHPrDDRYFLSGSLDGKLRLWNIPDKKVALwnEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEhlkyhTQIHV 707
Cdd:COG2319  210 VAFSP-DGKLLASGSADGTVRLWDLATGKLLR--TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA-----TGELL 281

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 708 RSTRGRNkvgRKITGIEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKGYVNSSSQIkaSFSHDFTYLVSGSEDKYVYI 787
Cdd:COG2319  282 RTLTGHS---GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFSPDGKTLASGSDDGTVRL 356

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 768039199 788 WstyhDLSKFTSVRRdrndfwegIKAHNAVVTSAIFAPNPSLMLS 832
Cdd:COG2319  357 W----DLATGELLRT--------LTGHTGAVTSVAFSPDGRTLAS 389
WD40 COG2319
WD40 repeat [General function prediction only];
485-832 2.73e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 127.33  E-value: 2.73e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 485 HMGAVWTMKFSHCGRLLASAGQDNVVRIWalknafdyfnnmrmkyntegrvspspsqeslsssksDTDTGVCSGTdedpd 564
Cdd:COG2319   77 HTAAVLSVAFSPDGRLLASASADGTVRLW------------------------------------DLATGLLLRT----- 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 565 dknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTAIAFHPrDDRYFLSGS 642
Cdd:COG2319  116 -------------LTGHTGAVRSVAFSPDgKTLASGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSP-DGKLLASGS 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 643 LDGKLRLWNIPDKKvaLWNEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEhlkyhTQIHVRSTRGRnkvGRKITG 722
Cdd:COG2319  182 DDGTVRLWDLATGK--LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA-----TGKLLRTLTGH---SGSVRS 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 723 IEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKGYVNSSSQIkaSFSHDFTYLVSGSEDKYVYIWstyhDLSKFTSVRr 802
Cdd:COG2319  252 VAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV--AFSPDGKLLASGSDDGTVRLW----DLATGKLLR- 324

                        330       340       350
                 ....*....|....*....|....*....|
gi 768039199 803 drndfweGIKAHNAVVTSAIFAPNPSLMLS 832
Cdd:COG2319  325 -------TLTGHTGAVRSVAFSPDGKTLAS 347
WD40 COG2319
WD40 repeat [General function prediction only];
470-748 1.99e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 121.56  E-value: 1.99e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 470 YDFDQIKVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNVVRIWalknafdyfnnmrmkyntegrvspspsqeslsssks 549
Cdd:COG2319  189 WDLATGKLLRTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLW------------------------------------ 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 550 DTDTGVCSGTdedpddknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTA 627
Cdd:COG2319  232 DLATGKLLRT------------------LTGHSGSVRSVAFSPDgRLLASGSADGTVRLWDLATGELLRTLTgHSGGVNS 293

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 628 IAFHPrDDRYFLSGSLDGKLRLWNIPDKKVAlwNEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEhlkyhTQIHV 707
Cdd:COG2319  294 VAFSP-DGKLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA-----TGELL 365

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 768039199 708 RSTRGRnkvGRKITGIEPLPGENKILVTSNDSRIRLYDLRD 748
Cdd:COG2319  366 RTLTGH---TGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
580-832 1.29e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.16  E-value: 1.29e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 580 GHTADLLDLSWSKNY-FLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTAIAFHPrDDRYFLSGSLDGKLRLWNIPDKKv 657
Cdd:COG2319   76 GHTAAVLSVAFSPDGrLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGK- 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 658 aLWNEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEHLKyhtqiHVRSTRGRNKVgrkITGIEPLPGENKILVTSN 737
Cdd:COG2319  154 -LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK-----LLRTLTGHTGA---VRSVAFSPDGKLLASGSA 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 738 DSRIRLYDLRDLSLSMKYKGYVNSSSQIkaSFSHDFTYLVSGSEDKYVYIWstyhDLSKFTSVRRdrndfwegIKAHNAV 817
Cdd:COG2319  225 DGTVRLWDLATGKLLRTLTGHSGSVRSV--AFSPDGRLLASGSADGTVRLW----DLATGELLRT--------LTGHSGG 290

                        250
                 ....*....|....*
gi 768039199 818 VTSAIFAPNPSLMLS 832
Cdd:COG2319  291 VNSVAFSPDGKLLAS 305
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 578-832 1.58e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 101.64  E-value: 1.58e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 578 YKGHTADLLDLSWSKNY-FLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTAIAFHPrDDRYFLSGSLDGKLRLWNIPDK 655
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGkLLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLETG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 656 KVAlwNEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEHLKYhtqihVRSTRGRNkvgrkitgieplpgenkilvt 735
Cdd:cd00200   84 ECV--RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC-----LTTLRGHT--------------------- 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 736 sndsrirlydlrdlslsmkykGYVNSssqikASFSHDFTYLVSGSEDKYVYIWstyhDLSKFTSVRRdrndfwegIKAHN 815
Cdd:cd00200  136 ---------------------DWVNS-----VAFSPDGTFVASSSQDGTIKLW----DLRTGKCVAT--------LTGHT 177

                        250
                 ....*....|....*..
gi 768039199 816 AVVTSAIFAPNPSLMLS 832
Cdd:cd00200  178 GEVNSVAFSPDGEKLLS 194
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 662-880 8.04e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.89  E-value: 8.04e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 662 EVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEHLKYHTQIHVRStrgrnkvgRKITGIEPLPGENKILVTSNDSRI 741
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHT--------GPVRDVAASADGTYLASGSSDKTI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 742 RLYDLRDLSLSMKYKG---YVNSssqikASFSHDFTYLVSGSEDKYVYIWstyhDLSKFTSVRRdrndfwegIKAHNAVV 818
Cdd:cd00200   76 RLWDLETGECVRTLTGhtsYVSS-----VAFSPDGRILSSSSRDKTIKVW----DVETGKCLTT--------LRGHTDWV 138

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768039199 819 TSAIFAPNPSLMLS---------LDVQSEKSEGNEKSEDAEVLDATPSGimktDNTEVLLSADfTGAIKVF 880
Cdd:cd00200  139 NSVAFSPDGTFVASssqdgtiklWDLRTGKCVATLTGHTGEVNSVAFSP----DGEKLLSSSS-DGTIKLW 204
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 613-651 1.48e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 1.48e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 768039199   613 RECLCCFQ-HIDFVTAIAFHPrDDRYFLSGSLDGKLRLWN 651
Cdd:smart00320   2 GELLKTLKgHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 476-513 3.07e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 3.07e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 768039199   476 KVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNVVRIW 513
Cdd:smart00320   3 ELLKTLKG-HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
613-651 7.67e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 7.67e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 768039199  613 RECLCCFQ-HIDFVTAIAFHPrDDRYFLSGSLDGKLRLWN 651
Cdd:pfam00400   1 GKLLKTLEgHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 571-659 2.41e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.02  E-value: 2.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 571 RQRPFCKYKGHTADLLDLSWSKNY--FLLSSSMDKTVRLWHISR--------RECLCCFQ-HIDFVTAIAFHPRDDRYFL 639
Cdd:PTZ00420  63 RKPPVIKLKGHTSSILDLQFNPCFseILASGSEDLTIRVWEIPHndesvkeiKDPQCILKgHKKKISIIDWNPMNYYIMC 142

                         90       100
                 ....*....|....*....|
gi 768039199 640 SGSLDGKLRLWNIPDKKVAL 659
Cdd:PTZ00420 143 SSGFDSFVNIWDIENEKRAF 162
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 598-792 2.90e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.77  E-value: 2.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 598 SSSMDKTVRLWHISRRECLCCF-QHIDFVTAIAFHPRDDRYFLSGSLDGKLRLWNIpDKKVALwnevdGQTKliTAANFC 676
Cdd:PLN00181 550 SSNFEGVVQVWDVARSQLVTEMkEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSI-NQGVSI-----GTIK--TKANIC 621

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 677 ------QNGKYAVIGTYDGRCIFYDTEHLKyhtqIHVRSTRGRNKVGRKITGIEplpgENKILVTSNDSRIRLYDLrDLS 750
Cdd:PLN00181 622 cvqfpsESGRSLAFGSADHKVYYYDLRNPK----LPLCTMIGHSKTVSYVRFVD----SSTLVSSSTDNTLKLWDL-SMS 692

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 768039199 751 LS-------MKYKGYVNSSSQIKASFSHDftYLVSGSEDKYVYIwstYH 792
Cdd:PLN00181 693 ISginetplHSFMGHTNVKNFVGLSVSDG--YIATGSETNEVFV---YH 736
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 573-609 4.35e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 4.35e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 768039199   573 RPFCKYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWH 609
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDgKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
476-513 5.31e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 5.31e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 768039199  476 KVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNVVRIW 513
Cdd:pfam00400   2 KLLKTLEG-HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
577-608 1.38e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 1.38e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 768039199  577 KYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLW 608
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDgKLLASGSDDGTVKVW 38
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 634-790 4.92e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 39.90  E-value: 4.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 634 DDRYFLSGsldGK---LRLWNIPDKKVALW-------NEVDGQTKL-ITAANFcqngkyavIGTYDGRCIFYDTEHlkyH 702
Cdd:cd22857  137 NENYFAFG---GKeveLNVWDLEEKPGKIWraknvpnDSLGLRVPVwVTDLTF--------LSKDDHRKIVTGTGY---H 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768039199 703 tQIHVRSTR-GR----NKVGRK--ITGIEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKGYvnSSSQIKASFSH-DFT 774
Cdd:cd22857  203 -QVRLYDTRaQRrpvvSVDFGEtpIKAVAEDPDGHTVYVGDTSGDLASIDLRTGKLLGCFKGK--CGGSIRSIARHpELP 279

                        170
                 ....*....|....*.
gi 768039199 775 YLVSGSEDKYVYIWST 790
Cdd:cd22857  280 LIASCGLDRYLRIWDT 295
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 756-789 5.34e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 5.34e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 768039199   756 KGYVNSssqikASFSHDFTYLVSGSEDKYVYIWS 789
Cdd:smart00320  12 TGPVTS-----VAFSPDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 470-514 8.80e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 39.24  E-value: 8.80e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 768039199 470 YDFDQIKVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNVVRIWA 514
Cdd:cd00200  246 WDLRTGECVQTLSG-HTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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