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Conserved domains on  [gi|767930960|ref|XP_011529868|]
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PR domain zinc finger protein 5 isoform X5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PR-SET_PRDM5 cd19190
PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 ...
 2-128 1.54e-97

PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 (also termed PR domain-containing protein 5) is a sequence-specific DNA-binding transcription factor that represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1.


:

Pssm-ID: 380967  Cd Length: 127  Bit Score: 293.04  E-value: 1.54e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960   2 LGMYVPDRFSLKSSRVQDGMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRLMWEVRGSKGEVLYILDATNPRHSNW 81
Cdd:cd19190    1 LGMYVPDRFSLKSSKVQDGMGLYTARRVKKGEKFGPFAGEKRMPNELDESMDPRLMWEVRGSKGEVLYILDASNPRHSNW 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 767930960  82 LRFVHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGYLDSDM 128
Cdd:cd19190   81 LRFVHEAPSQEQKNLAAIQEGENIFYLAVDDIETDTELLIGYLDSDM 127
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
225-463 9.62e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 9.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960 225 SSLKESSRSFQCSVCNSSFSSASSFEQHQETCRGDarFVCKADSCGKRLKSKDALKRHQENVH----TGDPKKKLICSVC 300
Cdd:COG5048  218 QNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSD--SSSSASESPRSSLPTASSQSSSPNESdsssEKGFSLPIKSKQC 295

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960 301 NKKCSSASSLQEHR--KIHEI-----FDC--QECMKKFISANQLKRHMITHSDMRLSPLIFLIEKRPYNCEICNKSFKRL 371
Cdd:COG5048  296 NISFSRSSPLTRHLrsVNHSGeslkpFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNEPPQSL 375

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960 372 DQvgahKVIHSEDKPYKC--KLCGKGFAHRNVYKNHKKTHSEERPFQCE--ECKALFRTPFSLQRHLLIHNSERTFKCHH 447
Cdd:COG5048  376 QQ----YKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSI 451

                        250
                 ....*....|....*.
gi 767930960 448 CDATFKRKDTLNVHVQ 463
Cdd:COG5048  452 LKSFRRDLDLSNHGKD 467
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 524-579 5.76e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.86  E-value: 5.76e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767930960 524 GERPYQCPY--CEKGFSKNDGLKMHiRTH--------------------TREKPYKCSECSKAFSQKRGLDEHkRTHT 579
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYH-MLHghqnqklhenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 470-551 1.21e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960 470 KKYRCEL--CNKAFVTPSVLRSHKKTHtgekekicpYCGQKFASSGTLRVHIRSHTGERPYQCPYCEKGFSKNDGLKMHi 547
Cdd:COG5189  348 KPYKCPVegCNKKYKNQNGLKYHMLHG---------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH- 417


                 ....
gi 767930960 548 RTHT 551
Cdd:COG5189  418 RKHS 421
SUF4-like super family cl41227
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 172-220 3.86e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


The actual alignment was detected with superfamily member cd20908:

Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.46  E-value: 3.86e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 767930960 172 CESSFTSEDILaehlqTLHQKpteEKEFKCKNCGKKFPVKQALQRHVLQ 220
Cdd:cd20908    7 CDREFDDEKIL-----IQHQK---AKHFKCHICHKKLYTAGGLAVHCLQ 47
 
Name Accession Description Interval E-value
PR-SET_PRDM5 cd19190
PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 ...
 2-128 1.54e-97

PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 (also termed PR domain-containing protein 5) is a sequence-specific DNA-binding transcription factor that represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1.


Pssm-ID: 380967  Cd Length: 127  Bit Score: 293.04  E-value: 1.54e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960   2 LGMYVPDRFSLKSSRVQDGMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRLMWEVRGSKGEVLYILDATNPRHSNW 81
Cdd:cd19190    1 LGMYVPDRFSLKSSKVQDGMGLYTARRVKKGEKFGPFAGEKRMPNELDESMDPRLMWEVRGSKGEVLYILDASNPRHSNW 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 767930960  82 LRFVHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGYLDSDM 128
Cdd:cd19190   81 LRFVHEAPSQEQKNLAAIQEGENIFYLAVDDIETDTELLIGYLDSDM 127
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 20-130 1.51e-07

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 50.41  E-value: 1.51e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960    20 GMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDY--------RLMWEVRGSkgevlYILDATnpRHSNWLRFV-HEAPS 90
Cdd:smart00317  12 GWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAydtdgakaFYLFDIDSD-----LCIDAR--RKGNLARFInHSCEP 84

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 767930960    91 QEQkNLAAIQEGENIFYL-AVEDIETDTELLIGYLDSDMEA 130
Cdd:smart00317  85 NCE-LLFVEVNGDDRIVIfALRDIKPGEELTIDYGSDYANE 124
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 20-123 1.21e-06

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 47.52  E-value: 1.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960   20 GMGLYTARRVRKGEKFGPFAGEKRM-PEDLDENMDYRLMWEVRGSKGEVL--------YILDATNPRHSNWLRFV-HEAP 89
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVLLItKEEADKRELLYYDKLELRLWGPYLftldedseYCIDARALYYGNWARFInHSCD 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 767930960   90 SQEQKNLAAIQEGENIFYLAVEDIETDTELLIGY 123
Cdd:pfam00856  81 PNCEVRVVYVNGGPRIVIFALRDIKPGEELTIDY 114
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
225-463 9.62e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 9.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960 225 SSLKESSRSFQCSVCNSSFSSASSFEQHQETCRGDarFVCKADSCGKRLKSKDALKRHQENVH----TGDPKKKLICSVC 300
Cdd:COG5048  218 QNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSD--SSSSASESPRSSLPTASSQSSSPNESdsssEKGFSLPIKSKQC 295

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960 301 NKKCSSASSLQEHR--KIHEI-----FDC--QECMKKFISANQLKRHMITHSDMRLSPLIFLIEKRPYNCEICNKSFKRL 371
Cdd:COG5048  296 NISFSRSSPLTRHLrsVNHSGeslkpFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNEPPQSL 375

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960 372 DQvgahKVIHSEDKPYKC--KLCGKGFAHRNVYKNHKKTHSEERPFQCE--ECKALFRTPFSLQRHLLIHNSERTFKCHH 447
Cdd:COG5048  376 QQ----YKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSI 451

                        250
                 ....*....|....*.
gi 767930960 448 CDATFKRKDTLNVHVQ 463
Cdd:COG5048  452 LKSFRRDLDLSNHGKD 467
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 524-579 5.76e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.86  E-value: 5.76e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767930960 524 GERPYQCPY--CEKGFSKNDGLKMHiRTH--------------------TREKPYKCSECSKAFSQKRGLDEHkRTHT 579
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYH-MLHghqnqklhenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 470-551 1.21e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960 470 KKYRCEL--CNKAFVTPSVLRSHKKTHtgekekicpYCGQKFASSGTLRVHIRSHTGERPYQCPYCEKGFSKNDGLKMHi 547
Cdd:COG5189  348 KPYKCPVegCNKKYKNQNGLKYHMLHG---------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH- 417


                 ....
gi 767930960 548 RTHT 551
Cdd:COG5189  418 RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
543-567 1.78e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.78e-04
                          10        20
                  ....*....|....*....|....*
gi 767930960  543 LKMHIRTHTREKPYKCSECSKAFSQ 567
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 172-220 3.86e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.46  E-value: 3.86e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 767930960 172 CESSFTSEDILaehlqTLHQKpteEKEFKCKNCGKKFPVKQALQRHVLQ 220
Cdd:cd20908    7 CDREFDDEKIL-----IQHQK---AKHFKCHICHKKLYTAGGLAVHCLQ 47
PHA00733 PHA00733
hypothetical protein
 501-547 1.36e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.09  E-value: 1.36e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 767930960 501 ICPYCGQKFASSGTLRVHIRshTGERPYQCPYCEKGFSKNDGLKMHI 547
Cdd:PHA00733  75 VCPLCLMPFSSSVSLKQHIR--YTEHSKVCPVCGKEFRNTDSTLDHV 119
 
Name Accession Description Interval E-value
PR-SET_PRDM5 cd19190
PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 ...
 2-128 1.54e-97

PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 (also termed PR domain-containing protein 5) is a sequence-specific DNA-binding transcription factor that represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1.


Pssm-ID: 380967  Cd Length: 127  Bit Score: 293.04  E-value: 1.54e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960   2 LGMYVPDRFSLKSSRVQDGMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRLMWEVRGSKGEVLYILDATNPRHSNW 81
Cdd:cd19190    1 LGMYVPDRFSLKSSKVQDGMGLYTARRVKKGEKFGPFAGEKRMPNELDESMDPRLMWEVRGSKGEVLYILDASNPRHSNW 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 767930960  82 LRFVHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGYLDSDM 128
Cdd:cd19190   81 LRFVHEAPSQEQKNLAAIQEGENIFYLAVDDIETDTELLIGYLDSDM 127
PR-SET_PRDM2 cd19188
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 ...
 3-127 7.51e-27

PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor.


Pssm-ID: 380965  Cd Length: 123  Bit Score: 105.22  E-value: 7.51e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960   3 GMYVPDRFSLKSSRVQDG-MGLYTARRVRKGEKFGPFAGEKRMPEDLDENmDYrlMWEVRGSKGEvLYILDATNPRHSNW 81
Cdd:cd19188    1 LMGLPEELELKPSAVDKTrIGVWAKKSIPKGRKFGPFVGEKKKRSQVKNN-VY--MWEIYGPKRG-WMCVDASDPTKGNW 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 767930960  82 LRFVHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGYLDSD 127
Cdd:cd19188   77 LRYVNWARSGEEQNLFPLQINRAIYYKTLKPIAPGEELLCWYNGED 122
PR-SET_PRDM16_PRDM3 cd19200
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus ...
 6-133 3.31e-25

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus protein and similar proteins; PRDM16 (also termed PR domain-containing protein 16, transcription factor MEL1, or MDS1/EVI1-like gene 1) functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells. It is closely related to paralog of PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) which is a nuclear transcription factor essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). PRDM3 and PRDM16 are both directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380977  Cd Length: 135  Bit Score: 101.29  E-value: 3.31e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960   6 VPDRFSLKSSRVQ-DGMGLYTARRVRKGEKFGPFAGEKRmpeDLDENMDYRlmWEVRGSKGEVLYILDATNPRHSNWLRF 84
Cdd:cd19200   10 IPPDFELRESAAVgAGLGVWTKVRIEVGEKFGPFVGVQR---SSVKDPTYA--WEIVDEFGKVKFWIDASEPGTGNWMKY 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 767930960  85 VHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIgYLDSDMEAEEE 133
Cdd:cd19200   85 IRSAPSCEQQNLMACQIDEQIYYKVVRDIQPGEELLL-YMKAAVYPHET 132
PR-SET_PRDM12 cd19196
PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 ...
 6-123 2.20e-24

PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 (also termed PR domain-containing protein 12) acts as a transcription factor that is involved in the positive regulation of histone H3-K9 dimethylation.


Pssm-ID: 380973 [Multi-domain]  Cd Length: 130  Bit Score: 98.58  E-value: 2.20e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960   6 VPDRFSLKSSRVQ-DGMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRLMWEVRGSKGEVLYILDATNPRHSNWLRF 84
Cdd:cd19196    1 LPSQVIIAQSSIPgAGLGVFSKTWIKEGTEMGPYTGRIVSPEDVDPCKNNNLMWEVFNEDGTVSHFIDASQENHRSWMTF 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 767930960  85 VHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGY 123
Cdd:cd19196   81 VNCARNEQEQNLEVVQIGESIYYRAIKDIPPDQELLVWY 119
PR-SET_PRDM7_9 cd19193
PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar ...
 6-126 9.31e-23

PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins; PRDM7 (also termed PR domain-containing protein 7) is a primate-specific histone methyltransferase that is the result of a recent gene duplication of PRDM9. It selectively catalyzes the trimethylation of H3 lysine 4 (H3K4me3). PRDM9 (also termed PR domain-containing protein 9) is a histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 (H3K4me3) during meiotic prophase and is essential for proper meiotic progression. It also efficiently mono-, di-, and trimethylates H3K36. Aberrant PRDM9 expression is assciated with with genome instability in cancer.


Pssm-ID: 380970 [Multi-domain]  Cd Length: 129  Bit Score: 93.84  E-value: 9.31e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960   6 VPDRFSLKSSRVQD-GMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMdYrlMWEVRGSKGEVLYIlDATNPRHSNWLRF 84
Cdd:cd19193    4 LPPGLSIKRSSIPGaGLGVWAEAPIPKGMVFGPYEGEIVEDEEAADSG-Y--SWQIYKGGKLSHYI-DAKDESKSNWMRY 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 767930960  85 VHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGYLDS 126
Cdd:cd19193   80 VNCARNEEEQNLVAFQYRGKIYYRTCKDIAPGTELLVWYGDE 121
PR-SET_PRDM1 cd19187
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ...
 7-123 5.55e-22

PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.


Pssm-ID: 380964 [Multi-domain]  Cd Length: 128  Bit Score: 91.62  E-value: 5.55e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960   7 PDRFSLKSSRVQ-DGMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRLMWEVRGSKGEVLYIlDATNPRHSNWLRFV 85
Cdd:cd19187    4 PRNLTLKYSSVGrEVLGVWSSDYIPRGTRFGPLVGEIYTNDPVPKGANRKYFWRIYSNGEFYHYI-DGFDPSKSNWMRYV 82

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767930960  86 HEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGY 123
Cdd:cd19187   83 NPAHSLQEQNLVACQIGMNIYFYTVKPIPPNQELLVWY 120
PR-SET_PRDM3 cd19214
PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also ...
 6-138 1.01e-21

PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) is a nuclear transcription factor, which is essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). It is closely related to paralog PRDM16, both o fwhich are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380991  Cd Length: 158  Bit Score: 91.92  E-value: 1.01e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960   6 VPDRFSLKSSRVQD-GMGLYTARRVRKGEKFGPFAGEKRMPEDldenmDYRLMWEVRGSKGEVLYILDATNPRHSNWLRF 84
Cdd:cd19214   30 IPSEFELRESNIPGtGLGIWTKRKIEVGEKFGPYVGEQRSNLK-----DPSYGWEVLDEFGNVKFCIDASQPDVGSWLKY 104

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767930960  85 VHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGyldsdMEAEEEEQQIM 138
Cdd:cd19214  105 IRFAGCYDQHNLVACQINDQIFYRAVADIDPGEELLLF-----MKSEDYSHETM 153
PR-SET_PRDM6 cd19191
PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 ...
 7-126 1.90e-19

PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 (also termed PR domain-containing protein 6) is a putative histone-lysine N-methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. It may specifically methylate 'Lys-20' of histone H4 when associated with other proteins and in vitro.


Pssm-ID: 380968  Cd Length: 128  Bit Score: 84.45  E-value: 1.90e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960   7 PDRFSL-KSSRVQDGMGLYTARRVRKGEKFGPFAGEKRMPEDLDENM-DYRLMWEVRGSKGEVLYILDATNPRHSNWLRF 84
Cdd:cd19191    2 PDEVCLcTSSIPGLGYGICAAQRIPQGTWIGPFEGVLVSPEKQIGAVrNTQHLWEIYDQEGTLQHFIDGGDPSKSSWMRY 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 767930960  85 VHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGYLDS 126
Cdd:cd19191   82 IRCARHCGEQNLTVVQYRGCIFYRACRDIPRGTELLVWYDDS 123
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 6-123 1.22e-18

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 80.70  E-value: 1.22e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960   6 VPDRFSL-KSSRVQDGMGLYTARRVRKGEKFGPFAGEKrmpedldenmdyrlmwevrgskgevlyildatnprhsNWLRF 84
Cdd:cd10534    1 LPAGLELvLSSIPEGGLGVFARRTIPAGTRFGPLEGVV-------------------------------------NWMRF 43

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 767930960  85 VHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGY 123
Cdd:cd10534   44 VRPARNEEEQNLVAYQHGGQIYFRTTRDIPPGEELLVWY 82
PR-SET_PRDM16 cd19213
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, ...
 6-128 2.84e-16

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, also termed PR domain-containing protein 16, or transcription factor MEL1, or MDS1/EVI1-like gene 1, functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells and is closely related to paralog of PRDM3, both of which are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380990  Cd Length: 162  Bit Score: 76.45  E-value: 2.84e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960   6 VPDRFSLKSSRVQD-GMGLYTARRVRKGEKFGPFAGEKRMP------------EDLDENMDYRLMWEVRGSKGEVLYILD 72
Cdd:cd19213   20 IPSDFELRESSIPGaGLGVWAKRKIEAGERFGPYTGVQRSTlkdtnfgweqilNDVEVSSQEGCITKIVDDLGNEKFCVD 99

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767930960  73 ATNPRHSNWLRFVHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLI-----GYLDSDM 128
Cdd:cd19213  100 AGQAGAGSWLKYIRVACSCDEQNLTACQINEQIYYKVIKDIEPGEELLVyvkdgVYPLGTM 160
PR-SET_PRDM14 cd19198
PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 ...
 22-125 8.53e-15

PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 (also termed PR domain-containing protein 14) acts as a transcription factor that has both positive and negative roles on transcription. It acts on regulating epigenetic modifications in the cells, playing a key role in the regulation of cell pluripotency, epigenetic reprogramming, differentiation and development. Aberrant PRDM14 expression is associated with tumorigenesis, cell migration and cell chemotherapeutic drugs resistance.


Pssm-ID: 380975  Cd Length: 133  Bit Score: 71.28  E-value: 8.53e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960  22 GLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRLMWEVRgSKGEVLYILDAtNPRHSNWLRFVHEAPSQEQKNLAAIQE 101
Cdd:cd19198   21 GVFCKKTIPKGTRFGPFRGRVVNTSEIKTYDDNSFMWEIF-EDGKLSHFIDG-RGSTGNWMSYVNCARYAEEQNLIAIQC 98

                         90       100
                 ....*....|....*....|....
gi 767930960 102 GENIFYLAVEDIETDTELLIGYLD 125
Cdd:cd19198   99 QGQIFYESCKEILQGQELLVWYGD 122
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 22-127 1.05e-14

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 70.84  E-value: 1.05e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960  22 GLYTARRVRKGEKFGPFAGekRMpEDLDENMDYRLMWEVRGSKGEVLYILDATNPrhSNWLRFVHEAPSQEQKNLAAIQE 101
Cdd:cd19201   21 GVWAKQPLPEGTRFGPYPG--KL-VKEPLDPSYEWKVEAQGSKGGEGLLLLTEDS--GTWLKLVRSADDEDEANLILYFK 95

                         90       100
                 ....*....|....*....|....*.
gi 767930960 102 GENIFYLAVEDIETDTELLIGYLDSD 127
Cdd:cd19201   96 GGQIWCEVTKDIPPGEELILVLREPL 121
PR-SET_PRDM10 cd19194
PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 ...
 22-123 8.45e-13

PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 (also termed PR domain-containing protein 10, or tristanin) may be involved in transcriptional regulation.


Pssm-ID: 380971  Cd Length: 128  Bit Score: 65.45  E-value: 8.45e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960  22 GLYTARRVRKGEKFGPFAGEkrMPEDLDENMDYRLMWEVRGSKGEVLYIlDATNPRHSNWLRFVHEAPSQEQKNLAAIQE 101
Cdd:cd19194   21 GVFAKRRIPKRTQFGPLEGP--LVKKSELKDNKIHPLELEEDDGEDLYF-DLSDENKCNWMMFVRPAQNHLEQNLVAYQY 97

                         90       100
                 ....*....|....*....|..
gi 767930960 102 GENIFYLAVEDIETDTELLIGY 123
Cdd:cd19194   98 GQEIYFTTIKNIEPKQELKVWY 119
PR-SET_PRDM4 cd19189
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 ...
 4-123 9.46e-13

PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation.


Pssm-ID: 380966  Cd Length: 133  Bit Score: 65.56  E-value: 9.46e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960   4 MYVPDRFSLKSSRVQDGMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRL--MWEVRgSKGEVLYILDATNPRHSNW 81
Cdd:cd19189    4 LSLPRQLYLRQSETGAEVGVWTKETIPVRTCFGPLIGQQSHSAEVADWTDKAAphIWKIY-HNDVLEFCIITTDENECNW 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 767930960  82 LRFVHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGY 123
Cdd:cd19189   83 MMFVRKARTREEQNLVAYPHDGKIYFCTSRDIPPDQELLFYY 124
PR-SET_PRDM15 cd19199
PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 ...
 11-123 6.93e-09

PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 (also termed PR domain-containing protein 15, or zinc finger protein 298 (ZNF298)) may be involved in transcriptional regulation. It plays an essential role as a chromatin factor that modulates the transcription of upstream regulators of WNT and MAPK-ERK signaling to safeguard naive pluripotency.


Pssm-ID: 380976  Cd Length: 126  Bit Score: 54.34  E-value: 6.93e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960  11 SLKSSRVQDGM-GLYTARRVRKGEKFGPFAGEK--RMPEdldENMDYRLMWEVRGSkgevLYILDATNPRHSNWLRFVHE 87
Cdd:cd19199   10 NLEIRQLEDGSeGVFALVPLVKRTQFGPFEAKRvaRLDG---FAVFPLKVFEKDGS----VVYLDTSNEDDCNWMMFVRP 82

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767930960  88 APSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGY 123
Cdd:cd19199   83 ATDVEHQNLTAYQQGEDIYFTTSRDIQPGAELRVWY 118
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 20-130 1.51e-07

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 50.41  E-value: 1.51e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960    20 GMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDY--------RLMWEVRGSkgevlYILDATnpRHSNWLRFV-HEAPS 90
Cdd:smart00317  12 GWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAydtdgakaFYLFDIDSD-----LCIDAR--RKGNLARFInHSCEP 84

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 767930960    91 QEQkNLAAIQEGENIFYL-AVEDIETDTELLIGYLDSDMEA 130
Cdd:smart00317  85 NCE-LLFVEVNGDDRIVIfALRDIKPGEELTIDYGSDYANE 124
PR-SET_PRDM13 cd19197
PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 ...
 32-123 3.92e-07

PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 (also termed PR domain-containing protein 13) may be involved in transcriptional regulation. It mediates the balance of inhibitory and excitatory neurons in somatosensory circuits.


Pssm-ID: 380974  Cd Length: 103  Bit Score: 48.66  E-value: 3.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960  32 GEKFGPFAGEKRMPEDLDENMDYRLMWEVRGSKGEvlYILDATNPRHSNWLRFVHEAPSQEQKNLAAIQE--GENIFYLA 109
Cdd:cd19197    4 GLRLGPVPGIFKLGKYLSDRKEPGNKKKVRRVRGD--YLVDESGSPATEWIGLVRAARNNQEQNLEAIADlpGGQIFYRA 81

                         90
                 ....*....|....
gi 767930960 110 VEDIETDTELLIGY 123
Cdd:cd19197   82 LRDIQPGEELTVWY 95
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 20-123 1.21e-06

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 47.52  E-value: 1.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960   20 GMGLYTARRVRKGEKFGPFAGEKRM-PEDLDENMDYRLMWEVRGSKGEVL--------YILDATNPRHSNWLRFV-HEAP 89
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVLLItKEEADKRELLYYDKLELRLWGPYLftldedseYCIDARALYYGNWARFInHSCD 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 767930960   90 SQEQKNLAAIQEGENIFYLAVEDIETDTELLIGY 123
Cdd:pfam00856  81 PNCEVRVVYVNGGPRIVIFALRDIKPGEELTIDY 114
PR-SET_PRDM17 cd10520
PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 ...
 6-121 7.10e-06

PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 (also termed zinc finger protein 408 (ZNF408)) may be involved in transcriptional regulation.


Pssm-ID: 380918  Cd Length: 121  Bit Score: 45.49  E-value: 7.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960   6 VPDRFSLKSSRVQD-GMGLY-TARRVRKGEKFGPFAGEKrMPEDLDENMDYRLmwEVRGSKGEVLYILDAtnprhSNWLR 83
Cdd:cd10520    5 LPPGLALGPSLAQEeRLGVWcVGDALQKGTFLGPLEEEL-ESHDLTEGGSPRQ--EESGQSGDVLACEQS-----SKWMR 76

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767930960  84 FVHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLI 121
Cdd:cd10520   77 FACRARSEEESNVAVVRLSGRLHLRVCKDIEPGSELLL 114
PR-SET_PRDM11 cd19195
PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 ...
 29-129 7.63e-06

PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 (also termed PR domain-containing protein 11) may be involved in transcription regulation.


Pssm-ID: 380972  Cd Length: 127  Bit Score: 45.62  E-value: 7.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960  29 VRKGEKFGPFAGEKrMPED----------LDENMDYRLmwevrgskgevlyiLDATNPRHSNWLRFVHEAPSQEQKNLAA 98
Cdd:cd19195   28 IPKGHIFGPYEGQI-CTQDkssgffswliVDKNNRYKS--------------IDGSDETKANWMRYVVISREEREQNLLA 92

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767930960  99 IQEGENIFYLAVEDIETDTELLIGYLDSDME 129
Cdd:cd19195   93 FQHSEQIYFRACRDIRPGEKLRVWYSEDYMK 123
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
225-463 9.62e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 9.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960 225 SSLKESSRSFQCSVCNSSFSSASSFEQHQETCRGDarFVCKADSCGKRLKSKDALKRHQENVH----TGDPKKKLICSVC 300
Cdd:COG5048  218 QNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSD--SSSSASESPRSSLPTASSQSSSPNESdsssEKGFSLPIKSKQC 295

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960 301 NKKCSSASSLQEHR--KIHEI-----FDC--QECMKKFISANQLKRHMITHSDMRLSPLIFLIEKRPYNCEICNKSFKRL 371
Cdd:COG5048  296 NISFSRSSPLTRHLrsVNHSGeslkpFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNEPPQSL 375

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960 372 DQvgahKVIHSEDKPYKC--KLCGKGFAHRNVYKNHKKTHSEERPFQCE--ECKALFRTPFSLQRHLLIHNSERTFKCHH 447
Cdd:COG5048  376 QQ----YKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSI 451

                        250
                 ....*....|....*.
gi 767930960 448 CDATFKRKDTLNVHVQ 463
Cdd:COG5048  452 LKSFRRDLDLSNHGKD 467
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 524-579 5.76e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.86  E-value: 5.76e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767930960 524 GERPYQCPY--CEKGFSKNDGLKMHiRTH--------------------TREKPYKCSECSKAFSQKRGLDEHkRTHT 579
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYH-MLHghqnqklhenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
262-587 8.34e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 8.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960 262 FVCKADSCGKRLKSKDALKRHQENVHTGDPkkklicSVCNKKCSSASSLQEHRKIheIFDCQECMKKFISANQLKRHMI- 340
Cdd:COG5048   62 SQCSYSGCDKSFSRPLELSRHLRTHHNNPS------DLNSKSLPLSNSKASSSSL--SSSSSNSNDNNLLSSHSLPPSSr 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960 341 --THSDMRLSPLIFLIEKRPYNCEICN--KSFKRLDQVGAHKVIHSEDKPYKCKLCGKG-FAHRNVYKNHKKTHSEERPF 415
Cdd:COG5048  134 dpQLPDLLSISNLRNNPLPGNNSSSVNtpQSNSLHPPLPANSLSKDPSSNLSLLISSNVsTSIPSSSENSPLSSSYSIPS 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960 416 QCEECKaLFRTPFSLQRHLLIHNSERTFKCH-----HCDATFKRKDTLNVHVQ--VVHERH--------------KKYRC 474
Cdd:COG5048  214 SSSDQN-LENSSSSLPLTTNSQLSPKSLLSQspsslSSSDSSSSASESPRSSLptASSQSSspnesdsssekgfsLPIKS 292

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960 475 ELCNKAFVTPSVLRSHKKT--HTGE--KEKICPY--CGQKFASSGTLRVHIRSHTGERPYQCPYCEKGFSKNDGLKMHIR 548
Cdd:COG5048  293 KQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNEPP 372

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 767930960 549 THTREKPYKC---------SECSKAFSQKRGLDEHKRTHTGEKPFQCD 587
Cdd:COG5048  373 QSLQQYKDLKndkksetlsNSCIRNFKRDSNLSLHIITHLSFRPYNCK 420
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 325-384 8.97e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 8.97e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767930960 325 CMKKFISANQLKRHMIT-HSDMRLSPL-------IFLIEKRPYNCEICNKSFKRLDQVGAHKViHSED 384
Cdd:COG5189  357 CNKKYKNQNGLKYHMLHgHQNQKLHENpspekmnIFSAKDKPYRCEVCDKRYKNLNGLKYHRK-HSHD 423
PR-SET_PRDM8 cd19192
PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 ...
 22-125 9.86e-05

PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 (also termed PR domain-containing protein 8) may function as histone methyltransferase, preferentially acting on 'Lys-9' of histone H3.


Pssm-ID: 380969  Cd Length: 131  Bit Score: 42.42  E-value: 9.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960  22 GLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRLMWEVRGSKGEVLYILDATNPRHSNWLRFVHEAPSQEQKNLAAIQE 101
Cdd:cd19192   21 SVVTTTDIPAGTIFGPCVLSFTLGYDIADIALKTTDKRVVPYIFRVDTGACNGSSEPSDWLRLVQPARDRHEQNLEAFRK 100

                         90       100
                 ....*....|....*....|....*
gi 767930960 102 GEN-IFYLAVEDIETDTELLIGYLD 125
Cdd:cd19192  101 NEGqVYFRTLRRIRKGEELLVWYSD 125
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 470-551 1.21e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960 470 KKYRCEL--CNKAFVTPSVLRSHKKTHtgekekicpYCGQKFASSGTLRVHIRSHTGERPYQCPYCEKGFSKNDGLKMHi 547
Cdd:COG5189  348 KPYKCPVegCNKKYKNQNGLKYHMLHG---------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH- 417


                 ....
gi 767930960 548 RTHT 551
Cdd:COG5189  418 RKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
145-338 1.25e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960 145 EVENSRRQSTAGRKDRLGCKEDYACPQCESSFTSEDILAEHLQTLHQKPTEEKEFKC--KNCGKKFPVKQALQRHVLQCT 222
Cdd:COG5048  268 ASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCpySLCGKLFSRNDALKRHILLHT 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960 223 AKSSLKESSRsfQCSVCNSSFSSASSFEQHQETCR--GDARFVCKADSCGKRLKSKDALKRHqENVHTGDPKKKLICSVC 300
Cdd:COG5048  348 SISPAKEKLL--NSSSKFSPLLNNEPPQSLQQYKDlkNDKKSETLSNSCIRNFKRDSNLSLH-IITHLSFRPYNCKNPPC 424

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 767930960 301 NKKCSSASSLQEHRKIHEIF--DCQECMKKFISANQLKRH 338
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHTNHapLLCSILKSFRRDLDLSNH 464
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 9-123 1.28e-04

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 41.94  E-value: 1.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960   9 RFSLKSSRVQDGMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRLMWevrgskgevLYILDATNP-------RHSNW 81
Cdd:cd10522    3 DISMIPNLSHNGLGLFAAETIAKGEFVGEYTGEVLDRWEEDRDSVYHYDP---------LYPFDLNGDilvidagKKGNL 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 767930960  82 LRFVHEAPsqeQKNLAAIQ---EGEN-IFYLAVEDIETDTELLIGY 123
Cdd:cd10522   74 TRFINHSD---QPNLELIVrtlKGEQhIGFVAIRDIKPGEELFISY 116
zf-H2C2_2 pfam13465
Zinc-finger double domain;
543-567 1.78e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.78e-04
                          10        20
                  ....*....|....*....|....*
gi 767930960  543 LKMHIRTHTREKPYKCSECSKAFSQ 567
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
526-587 2.32e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 2.32e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767930960 526 RPYQCPYCEKGFSKNDGLKMHIRTHTREKPYKCSECSKAFSQKRG--LDEHKRTHTGEKPFQCD 587
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNS 95
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 172-220 3.86e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.46  E-value: 3.86e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 767930960 172 CESSFTSEDILaehlqTLHQKpteEKEFKCKNCGKKFPVKQALQRHVLQ 220
Cdd:cd20908    7 CDREFDDEKIL-----IQHQK---AKHFKCHICHKKLYTAGGLAVHCLQ 47
zf-H2C2_2 pfam13465
Zinc-finger double domain;
515-539 4.88e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.88e-04
                          10        20
                  ....*....|....*....|....*
gi 767930960  515 LRVHIRSHTGERPYQCPYCEKGFSK 539
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 501-547 1.36e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.09  E-value: 1.36e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 767930960 501 ICPYCGQKFASSGTLRVHIRshTGERPYQCPYCEKGFSKNDGLKMHI 547
Cdd:PHA00733  75 VCPLCLMPFSSSVSLKQHIR--YTEHSKVCPVCGKEFRNTDSTLDHV 119
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 354-410 1.39e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.39e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767930960 354 IEKRPYNCEI--CNKSFKRLDQVGAHK-------------------VIHSEDKPYKCKLCGKGFAHRNVYKNHKKtHS 410
Cdd:COG5189  345 KDGKPYKCPVegCNKKYKNQNGLKYHMlhghqnqklhenpspekmnIFSAKDKPYRCEVCDKRYKNLNGLKYHRK-HS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
322-567 3.52e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 3.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960 322 CQECMKKFISANQLKRHMITHSDMrlSPLIFLIEkrPYNCEICNKSFKRLDQVGAHK--VIHS--EDKPYKC--KLCGKG 395
Cdd:COG5048  257 ASESPRSSLPTASSQSSSPNESDS--SSEKGFSL--PIKSKQCNISFSRSSPLTRHLrsVNHSgeSLKPFSCpySLCGKL 332

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960 396 FAHRNVYKNHKKTHSEERPFQCeeckaLFRTPFSLQRHLLIHNSERTFkCHHCDATFKRKDTLNVHvqvvherhkkyrce 475
Cdd:COG5048  333 FSRNDALKRHILLHTSISPAKE-----KLLNSSSKFSPLLNNEPPQSL-QQYKDLKNDKKSETLSN-------------- 392

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930960 476 LCNKAFVTPSVLRSHKKTHTGEKEKICPycgqkfassgtlrvhirshtgerpyqCPYCEKGFSKNDGLKMHIRTHTREKP 555
Cdd:COG5048  393 SCIRNFKRDSNLSLHIITHLSFRPYNCK--------------------------NPPCSKSFNRHYNLIPHKKIHTNHAP 446

                        250
                 ....*....|..
gi 767930960 556 YkCSECSKAFSQ 567
Cdd:COG5048  447 L-LCSILKSFRR 457
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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