NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767931246|ref|XP_011529981|]
View 

ATPase family gene 2 protein homolog A isoform X11 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CDC48 super family cl36852
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 323-779 0e+00

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


The actual alignment was detected with superfamily member TIGR01243:

Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 578.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  323 FYFISSTTRVNFTEIDKNSKEQDNQFKVTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTM 402
Cdd:TIGR01243 148 FVYVTEATEVEIREKPVREEIERKVPKVTYEDIGGLKEAKEKIREMVELPMKHPELFEHLGIEPPKGVLLYGPPGTGKTL 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  403 IARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMD 482
Cdd:TIGR01243 228 LAKAVANEAGAYFISINGPEIMSKYYGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEVTGEVEKRVVAQLLTLMD 307

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  483 GIGSEvseGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPhLLTEAELLQLANSAHGYVGA 562
Cdd:TIGR01243 308 GLKGR---GRVIVIGATNRPDALDPALRRPGRFDREIVIRVPDKRARKEILKVHTRNMP-LAEDVDLDKLAEVTHGFVGA 383

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  563 DLKVLCNEAGLCALRRILKKQPNLPDVK-----VAGLVKITLKDFLQAMNDIRPSAMREIAIDVPNVSWSDIGGLESIKL 637
Cdd:TIGR01243 384 DLAALAKEAAMAALRRFIREGKINFEAEeipaeVLKELKVTMKDFMEALKMVEPSAIREVLVEVPNVRWSDIGGLEEVKQ 463

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  638 KLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRKAR 717
Cdd:TIGR01243 464 ELREAVEWPLKHPEIFEKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVGESEKAIREIFRKAR 543

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767931246  718 AVAPSIIFFDELDALAVERGSSLGAgNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRID 779
Cdd:TIGR01243 544 QAAPAIIFFDEIDAIAPARGARFDT-SVTDRIVNQLLTEMDGIQELSNVVVIAATNRPDILD 604
CDC48_N super family cl21693
Cell division protein 48 (CDC48), N-terminal domain; This domain has a double psi-beta barrel ...
 65-133 1.14e-04

Cell division protein 48 (CDC48), N-terminal domain; This domain has a double psi-beta barrel fold and includes VCP-like ATPase and N-ethylmaleimide sensitive fusion protein N-terminal domains. Both the VAT and NSF N-terminal functional domains consist of two structural domains of which this is at the N-terminus. The VAT-N domain found in AAA ATPases pfam00004 is a substrate 185-residue recognition domain.


The actual alignment was detected with superfamily member smart01073:

Pssm-ID: 451359 [Multi-domain]  Cd Length: 82  Bit Score: 41.44  E-value: 1.14e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246    65 NSLIHLGLNTMKSANICIGRPVLLTslNGKQEVYTAWP-MAGFPGGKVGLSEMAQKNVGVRPGDAIQVQP 133
Cdd:smart01073  14 RGIARLSPEDMDELGLFPGDYVLIT--GKRRTVAIVWPaYPEDPGGIIRIDGVQRKNAGVSIGDTVTVRK 81
 
Name Accession Description Interval E-value
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 323-779 0e+00

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 578.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  323 FYFISSTTRVNFTEIDKNSKEQDNQFKVTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTM 402
Cdd:TIGR01243 148 FVYVTEATEVEIREKPVREEIERKVPKVTYEDIGGLKEAKEKIREMVELPMKHPELFEHLGIEPPKGVLLYGPPGTGKTL 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  403 IARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMD 482
Cdd:TIGR01243 228 LAKAVANEAGAYFISINGPEIMSKYYGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEVTGEVEKRVVAQLLTLMD 307

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  483 GIGSEvseGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPhLLTEAELLQLANSAHGYVGA 562
Cdd:TIGR01243 308 GLKGR---GRVIVIGATNRPDALDPALRRPGRFDREIVIRVPDKRARKEILKVHTRNMP-LAEDVDLDKLAEVTHGFVGA 383

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  563 DLKVLCNEAGLCALRRILKKQPNLPDVK-----VAGLVKITLKDFLQAMNDIRPSAMREIAIDVPNVSWSDIGGLESIKL 637
Cdd:TIGR01243 384 DLAALAKEAAMAALRRFIREGKINFEAEeipaeVLKELKVTMKDFMEALKMVEPSAIREVLVEVPNVRWSDIGGLEEVKQ 463

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  638 KLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRKAR 717
Cdd:TIGR01243 464 ELREAVEWPLKHPEIFEKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVGESEKAIREIFRKAR 543

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767931246  718 AVAPSIIFFDELDALAVERGSSLGAgNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRID 779
Cdd:TIGR01243 544 QAAPAIIFFDEIDAIAPARGARFDT-SVTDRIVNQLLTEMDGIQELSNVVVIAATNRPDILD 604
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 350-616 3.76e-97

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 305.01  E-value: 3.76e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 350 VTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYG 429
Cdd:COG1222   75 VTFDDIGGLDEQIEEIREAVELPLKNPELFRKYGIEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKYIG 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 430 ETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVE-KRVVASLLTLMDGIGsevSEGQVLVLGATNRPHALDAA 508
Cdd:COG1222  155 EGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDGTSGEvQRTVNQLLAELDGFE---SRGDVLIIAATNRPDLLDPA 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 509 LRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPhLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRRilkkqpnlpd 588
Cdd:COG1222  232 LLRPGRFDRVIEVPLPDEEAREEILKIHLRDMP-LADDVDLDKLAKLTEGFSGADLKAIVTEAGMFAIRE---------- 300

                        250       260
                 ....*....|....*....|....*...
gi 767931246 589 vkvaGLVKITLKDFLQAMNDIRPSAMRE 616
Cdd:COG1222  301 ----GRDTVTMEDLEKAIEKVKKKTETA 324
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 635-779 3.71e-89

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 277.63  E-value: 3.71e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 635 IKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFR 714
Cdd:cd19511    1 VKRELKEAVEWPLKHPDAFKRLGIRPPKGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGESERAVREIFQ 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767931246 715 KARAVAPSIIFFDELDALAVERGSSlGAGNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRID 779
Cdd:cd19511   81 KARQAAPCIIFFDEIDSLAPRRGQS-DSSGVTDRVVSQLLTELDGIESLKGVVVIAATNRPDMID 144
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 349-622 1.72e-71

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 239.35  E-value: 1.72e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 349 KVTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFY 428
Cdd:PRK03992 127 NVTYEDIGGLEEQIREVREAVELPLKKPELFEEVGIEPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFI 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 429 GETeAKL-RQIFAEATLRHPSIIFIDELDALCPKR----EGAQNEVEkRVVASLLTLMDGIGsevSEGQVLVLGATNRPH 503
Cdd:PRK03992 207 GEG-ARLvRELFELAREKAPSIIFIDEIDAIAAKRtdsgTSGDREVQ-RTLMQLLAEMDGFD---PRGNVKIIAATNRID 281

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 504 ALDAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVpHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRRilkkq 583
Cdd:PRK03992 282 ILDPAILRPGRFDRIIEVPLPDEEGRLEILKIHTRKM-NLADDVDLEELAELTEGASGADLKAICTEAGMFAIRD----- 355

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 767931246 584 pnlpdvkvaGLVKITLKDFLQAMNDIRPSAMREIAIDVP 622
Cdd:PRK03992 356 ---------DRTEVTMEDFLKAIEKVMGKEEKDSMEEPG 385
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 390-523 7.51e-50

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 171.24  E-value: 7.51e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  390 VLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEV 469
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDSE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767931246  470 EKRVVASLLTLMDGIgsEVSEGQVLVLGATNRPHALDAALRrpGRFDKEIEIGV 523
Cdd:pfam00004  81 SRRVVNQLLTELDGF--TSSNSKVIVIAATNRPDKLDPALL--GRFDRIIEFPL 130
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 387-525 1.54e-15

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 74.33  E-value: 1.54e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246   387 PRGVLLYGPPGTGKTMIARAVANEVGAY---VSVINGPEI--------------ISKFYGETEAKLRQIFAEATLRHPSI 449
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPgggVIYIDGEDIleevldqllliivgGKKASGSGELRLRLALALARKLKPDV 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767931246   450 IFIDELDALCPKREGAQNEVEKRVVAslltlmdgIGSEVSEGQVLVLGATNRPHALDAALRRPgRFDKEIEIGVPN 525
Cdd:smart00382  82 LILDEITSLLDAEQEALLLLLEELRL--------LLLLKSEKNLTVILTTNDEKDLGPALLRR-RFDRRIVLLLIL 148
CDC48_N smart01073
Cell division protein 48 (CDC48) N-terminal domain; This domain has a double psi-beta barrel ...
 65-133 1.14e-04

Cell division protein 48 (CDC48) N-terminal domain; This domain has a double psi-beta barrel fold and includes VCP-like ATPase and N-ethylmaleimide sensitive fusion protein N-terminal domains. Both the VAT and NSF N-terminal functional domains consist of two structural domains of which this is at the N-terminus. The VAT-N domain found in AAA ATPases is a substrate 185-residue recognition domain.


Pssm-ID: 215012 [Multi-domain]  Cd Length: 82  Bit Score: 41.44  E-value: 1.14e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246    65 NSLIHLGLNTMKSANICIGRPVLLTslNGKQEVYTAWP-MAGFPGGKVGLSEMAQKNVGVRPGDAIQVQP 133
Cdd:smart01073  14 RGIARLSPEDMDELGLFPGDYVLIT--GKRRTVAIVWPaYPEDPGGIIRIDGVQRKNAGVSIGDTVTVRK 81
 
Name Accession Description Interval E-value
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 323-779 0e+00

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 578.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  323 FYFISSTTRVNFTEIDKNSKEQDNQFKVTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTM 402
Cdd:TIGR01243 148 FVYVTEATEVEIREKPVREEIERKVPKVTYEDIGGLKEAKEKIREMVELPMKHPELFEHLGIEPPKGVLLYGPPGTGKTL 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  403 IARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMD 482
Cdd:TIGR01243 228 LAKAVANEAGAYFISINGPEIMSKYYGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEVTGEVEKRVVAQLLTLMD 307

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  483 GIGSEvseGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPhLLTEAELLQLANSAHGYVGA 562
Cdd:TIGR01243 308 GLKGR---GRVIVIGATNRPDALDPALRRPGRFDREIVIRVPDKRARKEILKVHTRNMP-LAEDVDLDKLAEVTHGFVGA 383

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  563 DLKVLCNEAGLCALRRILKKQPNLPDVK-----VAGLVKITLKDFLQAMNDIRPSAMREIAIDVPNVSWSDIGGLESIKL 637
Cdd:TIGR01243 384 DLAALAKEAAMAALRRFIREGKINFEAEeipaeVLKELKVTMKDFMEALKMVEPSAIREVLVEVPNVRWSDIGGLEEVKQ 463

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  638 KLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRKAR 717
Cdd:TIGR01243 464 ELREAVEWPLKHPEIFEKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVGESEKAIREIFRKAR 543

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767931246  718 AVAPSIIFFDELDALAVERGSSLGAgNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRID 779
Cdd:TIGR01243 544 QAAPAIIFFDEIDAIAPARGARFDT-SVTDRIVNQLLTEMDGIQELSNVVVIAATNRPDILD 604
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 350-616 3.76e-97

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 305.01  E-value: 3.76e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 350 VTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYG 429
Cdd:COG1222   75 VTFDDIGGLDEQIEEIREAVELPLKNPELFRKYGIEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKYIG 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 430 ETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVE-KRVVASLLTLMDGIGsevSEGQVLVLGATNRPHALDAA 508
Cdd:COG1222  155 EGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDGTSGEvQRTVNQLLAELDGFE---SRGDVLIIAATNRPDLLDPA 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 509 LRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPhLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRRilkkqpnlpd 588
Cdd:COG1222  232 LLRPGRFDRVIEVPLPDEEAREEILKIHLRDMP-LADDVDLDKLAKLTEGFSGADLKAIVTEAGMFAIRE---------- 300

                        250       260
                 ....*....|....*....|....*...
gi 767931246 589 vkvaGLVKITLKDFLQAMNDIRPSAMRE 616
Cdd:COG1222  301 ----GRDTVTMEDLEKAIEKVKKKTETA 324
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 635-779 3.71e-89

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 277.63  E-value: 3.71e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 635 IKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFR 714
Cdd:cd19511    1 VKRELKEAVEWPLKHPDAFKRLGIRPPKGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGESERAVREIFQ 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767931246 715 KARAVAPSIIFFDELDALAVERGSSlGAGNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRID 779
Cdd:cd19511   81 KARQAAPCIIFFDEIDSLAPRRGQS-DSSGVTDRVVSQLLTELDGIESLKGVVVIAATNRPDMID 144
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 355-521 7.28e-89

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 277.25  E-value: 7.28e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 355 IGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAK 434
Cdd:cd19503    2 IGGLDEQIASLKELIELPLKYPELFRALGLKPPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGESEKN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 435 LRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGsevSEGQVLVLGATNRPHALDAALRRPGR 514
Cdd:cd19503   82 LREIFEEARSHAPSIIFIDEIDALAPKREEDQREVERRVVAQLLTLMDGMS---SRGKVVVIAATNRPDAIDPALRRPGR 158


                 ....*..
gi 767931246 515 FDKEIEI 521
Cdd:cd19503  159 FDREVEI 165
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 355-522 3.91e-85

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 267.38  E-value: 3.91e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 355 IGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAK 434
Cdd:cd19519    2 IGGCRKQLAQIREMVELPLRHPELFKAIGIKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 435 LRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGsevSEGQVLVLGATNRPHALDAALRRPGR 514
Cdd:cd19519   82 LRKAFEEAEKNAPAIIFIDEIDAIAPKREKTHGEVERRIVSQLLTLMDGLK---QRAHVIVMAATNRPNSIDPALRRFGR 158


                 ....*...
gi 767931246 515 FDKEIEIG 522
Cdd:cd19519  159 FDREIDIG 166
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 575-779 2.14e-77

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 253.01  E-value: 2.14e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 575 ALRRILKKQPNLPDVKVAGLVKITLKDFLQAMNDIRPSAMREiaidVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFI 654
Cdd:COG1222   30 ALLLQPVKALELLEEAPALLLNDANLTQKRLGTPRGTAVPAE----SPDVTFDDIGGLDEQIEEIREAVELPLKNPELFR 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 655 RMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFFDELDALAV 734
Cdd:COG1222  106 KYGIEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKYIGEGARNVREVFELAREKAPSIIFIDEIDAIAA 185

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 767931246 735 ERGSSLGAGNVaDRVLAQLLTEMDGIEQLKDVTILAATNRPDRID 779
Cdd:COG1222  186 RRTDDGTSGEV-QRTVNQLLAELDGFESRGDVLIIAATNRPDLLD 229
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 329-610 4.87e-77

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 254.45  E-value: 4.87e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 329 TTRVNFTEIDKNSKEQDNQFKVTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVA 408
Cdd:COG0464  133 APLVTYEDIGGLEEELLELREAILDDLGGLEEVKEELRELVALPLKRPELREEYGLPPPRGLLLYGPPGTGKTLLARALA 212

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 409 NEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIgsev 488
Cdd:COG0464  213 GELGLPLIEVDLSDLVSKYVGETEKNLREVFDKARGLAPCVLFIDEADALAGKRGEVGDGVGRRVVNTLLTEMEEL---- 288

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 489 sEGQVLVLGATNRPHALDAALRRpgRFDKEIEIGVPNAQDRLDILQKLLRRVPhLLTEAELLQLANSAHGYVGADLKVLC 568
Cdd:COG0464  289 -RSDVVVIAATNRPDLLDPALLR--RFDEIIFFPLPDAEERLEIFRIHLRKRP-LDEDVDLEELAEATEGLSGADIRNVV 364

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 767931246 569 NEAGLCALRRILKkqpnlpdvkvaglvKITLKDFLQAMNDIR 610
Cdd:COG0464  365 RRAALQALRLGRE--------------PVTTEDLLEALERED 392
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 349-622 1.72e-71

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 239.35  E-value: 1.72e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 349 KVTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFY 428
Cdd:PRK03992 127 NVTYEDIGGLEEQIREVREAVELPLKKPELFEEVGIEPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFI 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 429 GETeAKL-RQIFAEATLRHPSIIFIDELDALCPKR----EGAQNEVEkRVVASLLTLMDGIGsevSEGQVLVLGATNRPH 503
Cdd:PRK03992 207 GEG-ARLvRELFELAREKAPSIIFIDEIDAIAAKRtdsgTSGDREVQ-RTLMQLLAEMDGFD---PRGNVKIIAATNRID 281

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 504 ALDAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVpHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRRilkkq 583
Cdd:PRK03992 282 ILDPAILRPGRFDRIIEVPLPDEEGRLEILKIHTRKM-NLADDVDLEELAELTEGASGADLKAICTEAGMFAIRD----- 355

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 767931246 584 pnlpdvkvaGLVKITLKDFLQAMNDIRPSAMREIAIDVP 622
Cdd:PRK03992 356 ---------DRTEVTMEDFLKAIEKVMGKEEKDSMEEPG 385
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 635-779 5.47e-70

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 226.99  E-value: 5.47e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 635 IKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFR 714
Cdd:cd19529    1 VKQELKEAVEWPLLKPEVFKRLGIRPPKGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGESEKAIREIFR 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767931246 715 KARAVAPSIIFFDELDALAVERGSSLGAGnVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRID 779
Cdd:cd19529   81 KARQVAPCVIFFDEIDSIAPRRGTTGDSG-VTERVVNQLLTELDGLEEMNGVVVIAATNRPDIID 144
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 350-616 1.65e-68

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 240.58  E-value: 1.65e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  350 VTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYG 429
Cdd:TIGR01243 450 VRWSDIGGLEEVKQELREAVEWPLKHPEIFEKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVG 529

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  430 ETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNE-VEKRVVASLLTLMDGIgseVSEGQVLVLGATNRPHALDAA 508
Cdd:TIGR01243 530 ESEKAIREIFRKARQAAPAIIFFDEIDAIAPARGARFDTsVTDRIVNQLLTEMDGI---QELSNVVVIAATNRPDILDPA 606

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  509 LRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPhLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRRILKKQPN--- 585
Cdd:TIGR01243 607 LLRPGRFDRLILVPPPDEEARKEIFKIHTRSMP-LAEDVDLEELAEMTEGYTGADIEAVCREAAMAALRESIGSPAKekl 685

                         250       260       270
                  ....*....|....*....|....*....|..
gi 767931246  586 -LPDVKVAGLVKITLKDFLQAMNDIRPSAMRE 616
Cdd:TIGR01243 686 eVGEEEFLKDLKVEMRHFLEALKKVKPSVSKE 717
26Sp45 TIGR01242
26S proteasome subunit P45 family; Many proteins may score above the trusted cutoff because an ...
 343-609 1.18e-65

26S proteasome subunit P45 family; Many proteins may score above the trusted cutoff because an internal


Pssm-ID: 130309 [Multi-domain]  Cd Length: 364  Bit Score: 222.75  E-value: 1.18e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  343 EQDNQFKVTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPE 422
Cdd:TIGR01242 112 EVEERPNVSYEDIGGLEEQIREIREAVELPLKHPELFEEVGIEPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSE 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  423 IISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKR----EGAQNEVEkRVVASLLTLMDGIGsevSEGQVLVLGA 498
Cdd:TIGR01242 192 LVRKYIGEGARLVREIFELAKEKAPSIIFIDEIDAIAAKRtdsgTSGDREVQ-RTLMQLLAELDGFD---PRGNVKVIAA 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  499 TNRPHALDAALRRPGRFDKEIEIGVPNAQDRLDILqKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRR 578
Cdd:TIGR01242 268 TNRPDILDPALLRPGRFDRIIEVPLPDFEGRLEIL-KIHTRKMKLAEDVDLEAIAKMTEGASGADLKAICTEAGMFAIRE 346

                         250       260       270
                  ....*....|....*....|....*....|.
gi 767931246  579 ilkkqpnlpdvkvaGLVKITLKDFLQAMNDI 609
Cdd:TIGR01242 347 --------------ERDYVTMDDFIKAVEKV 363
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 355-519 2.61e-63

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 209.57  E-value: 2.61e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 355 IGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAK 434
Cdd:cd19518    2 IGGMDSTLKELCELLIHPILPPEYFQHLGVEPPRGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGESEEK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 435 LRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGSEVSEGQ-VLVLGATNRPHALDAALRRPG 513
Cdd:cd19518   82 IRELFDQAISNAPCIVFIDEIDAITPKRESAQREMERRIVSQLLTCMDELNNEKTAGGpVLVIGATNRPDSLDPALRRAG 161


                 ....*.
gi 767931246 514 RFDKEI 519
Cdd:cd19518  162 RFDREI 167
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 635-780 3.45e-63

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 208.90  E-value: 3.45e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 635 IKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFR 714
Cdd:cd19528    1 VKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFD 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767931246 715 KARAVAPSIIFFDELDALAVERGSSLG-AGNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRIDK 780
Cdd:cd19528   81 KARAAAPCVLFFDELDSIAKARGGNIGdAGGAADRVINQILTEMDGMNTKKNVFIIGATNRPDIIDP 147
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 494-779 5.54e-62

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 214.00  E-value: 5.54e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 494 LVLGATNRPHALDAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGL 573
Cdd:COG0464   26 LLLLLLALAAALLLLLLLLLLLLLALLLVELLLLLLSGALAALLLLALLLLALLALLAALLSALELLLLGELLLLLLLLL 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 574 CALRRILKKQPNLPDVKVAGLVKITLKDFLQAMNDIRPsaMREIAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESF 653
Cdd:COG0464  106 LLLLLLLDLERALLELLRESAEALALAAPLVTYEDIGG--LEEELLELREAILDDLGGLEEVKEELRELVALPLKRPELR 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 654 IRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFFDELDALA 733
Cdd:COG0464  184 EEYGLPPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSKYVGETEKNLREVFDKARGLAPCVLFIDEADALA 263

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 767931246 734 VERGSSlgAGNVADRVLAQLLTEMDGIEqlKDVTILAATNRPDRID 779
Cdd:COG0464  264 GKRGEV--GDGVGRRVVNTLLTEMEELR--SDVVVIAATNRPDLLD 305
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 628-779 7.39e-62

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 205.22  E-value: 7.39e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 628 DIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESER 707
Cdd:cd19503    1 DIGGLDEQIASLKELIELPLKYPELFRALGLKPPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGESEK 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767931246 708 AVRETFRKARAVAPSIIFFDELDALAVERGSSLGAgnVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRID 779
Cdd:cd19503   81 NLREIFEEARSHAPSIIFIDEIDALAPKREEDQRE--VERRVVAQLLTLMDGMSSRGKVVVIAATNRPDAID 150
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 587-779 4.39e-61

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 211.23  E-value: 4.39e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 587 PDVKVA------GLVKItlkdfLQAMNDIRPSAMrEIaIDVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQP 660
Cdd:PRK03992  92 PGARVAlnqqslAIVEV-----LPSEKDPRVQAM-EV-IESPNVTYEDIGGLEEQIREVREAVELPLKKPELFEEVGIEP 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 661 PKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFFDELDALAVERGSSL 740
Cdd:PRK03992 165 PKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFIGEGARLVRELFELAREKAPSIIFIDEIDAIAAKRTDSG 244

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 767931246 741 GAGN--VaDRVLAQLLTEMDGIEQLKDVTILAATNRPDRID 779
Cdd:PRK03992 245 TSGDreV-QRTLMQLLAEMDGFDPRGNVKIIAATNRIDILD 284
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 632-779 2.71e-60

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 200.79  E-value: 2.71e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 632 LESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRE 711
Cdd:cd19530    1 LDHVREELTMSILRPIKRPDIYKALGIDLPTGVLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGESERAVRQ 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767931246 712 TFRKARAVAPSIIFFDELDALAVERGSSLGAGNVadRVLAQLLTEMDGIEQLKDVTILAATNRPDRID 779
Cdd:cd19530   81 VFQRARASAPCVIFFDEVDALVPKRGDGGSWASE--RVVNQLLTEMDGLEERSNVFVIAATNRPDIID 146
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 363-519 1.55e-59

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 198.66  E-value: 1.55e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 363 KAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEA 442
Cdd:cd19511    3 RELKEAVEWPLKHPDAFKRLGIRPPKGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGESERAVREIFQKA 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767931246 443 TLRHPSIIFIDELDALCPKReGAQNE--VEKRVVASLLTLMDGIGSEVsegQVLVLGATNRPHALDAALRRPGRFDKEI 519
Cdd:cd19511   83 RQAAPCIIFFDEIDSLAPRR-GQSDSsgVTDRVVSQLLTELDGIESLK---GVVVIAATNRPDMIDPALLRPGRLDKLI 157
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 625-779 5.58e-59

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 197.56  E-value: 5.58e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 625 SWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGE 704
Cdd:cd19502    1 TYEDIGGLDEQIREIREVVELPLKHPELFEELGIEPPKGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIGE 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767931246 705 SERAVRETFRKARAVAPSIIFFDELDALAVERGSSLGAG-NVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRID 779
Cdd:cd19502   81 GARLVRELFEMAREKAPSIIFIDEIDAIGAKRFDSGTGGdREVQRTMLELLNQLDGFDPRGNIKVIMATNRPDILD 156
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 351-521 9.38e-59

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 197.17  E-value: 9.38e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 351 TYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGE 430
Cdd:cd19502    1 TYEDIGGLDEQIREIREVVELPLKHPELFEELGIEPPKGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIGE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 431 TEAKLRQIFAEATLRHPSIIFIDELDALCPKRE----GAQNEVEkRVVASLLTLMDGIGsevSEGQVLVLGATNRPHALD 506
Cdd:cd19502   81 GARLVRELFEMAREKAPSIIFIDEIDAIGAKRFdsgtGGDREVQ-RTMLELLNQLDGFD---PRGNIKVIMATNRPDILD 156

                        170
                 ....*....|....*
gi 767931246 507 AALRRPGRFDKEIEI 521
Cdd:cd19502  157 PALLRPGRFDRKIEF 171
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
353-610 2.63e-58

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 198.57  E-value: 2.63e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 353 DMIGGlSSQLKAIREIIElPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETE 432
Cdd:COG1223    3 DVVGQ-EEAKKKLKLIIK-ELRRRENLRKFGLWPPRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSLIGSYLGETA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 433 AKLRQIFAEATlRHPSIIFIDELDALCpKREGAQNEV-E-KRVVASLLTLMDGIGSEvsegqVLVLGATNRPHALDAALR 510
Cdd:COG1223   81 RNLRKLFDFAR-RAPCVIFFDEFDAIA-KDRGDQNDVgEvKRVVNALLQELDGLPSG-----SVVIAATNHPELLDSALW 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 511 RpgRFDKEIEIGVPNAQDRLDILQKLLRRVPhLLTEAELLQLANSAHGYVGADLKVLCneaglcalRRILKKQpnlpdvK 590
Cdd:COG1223  154 R--RFDEVIEFPLPDKEERKEILELNLKKFP-LPFELDLKKLAKKLEGLSGADIEKVL--------KTALKKA------I 216

                        250       260
                 ....*....|....*....|
gi 767931246 591 VAGLVKITLKDFLQAMNDIR 610
Cdd:COG1223  217 LEDREKVTKEDLEEALKQRK 236
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 628-779 4.08e-58

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 195.35  E-value: 4.08e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 628 DIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESER 707
Cdd:cd19519    1 DIGGCRKQLAQIREMVELPLRHPELFKAIGIKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESES 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767931246 708 AVRETFRKARAVAPSIIFFDELDALAVERGSSlgAGNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRID 779
Cdd:cd19519   81 NLRKAFEEAEKNAPAIIFIDEIDAIAPKREKT--HGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSID 150
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 361-521 9.75e-57

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 190.96  E-value: 9.75e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 361 QLKAIREIIELPLKQPELFKsYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFA 440
Cdd:cd19481    1 LKASLREAVEAPRRGSRLRR-YGLGLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGESEKNLRKIFE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 441 EATLRHPSIIFIDELDALCPKREG-AQNEVEKRVVASLLTLMDGIgseVSEGQVLVLGATNRPHALDAALRRPGRFDKEI 519
Cdd:cd19481   80 RARRLAPCILFIDEIDAIGRKRDSsGESGELRRVLNQLLTELDGV---NSRSKVLVIAATNRPDLLDPALLRPGRFDEVI 156


                 ..
gi 767931246 520 EI 521
Cdd:cd19481  157 EF 158
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 365-521 4.06e-55

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 186.93  E-value: 4.06e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 365 IREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATL 444
Cdd:cd19529    5 LKEAVEWPLLKPEVFKRLGIRPPKGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGESEKAIREIFRKARQ 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767931246 445 RHPSIIFIDELDALCPKR-EGAQNEVEKRVVASLLTLMDGIgseVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEI 521
Cdd:cd19529   85 VAPCVIFFDEIDSIAPRRgTTGDSGVTERVVNQLLTELDGL---EEMNGVVVIAATNRPDIIDPALLRAGRFDRLIYI 159
26Sp45 TIGR01242
26S proteasome subunit P45 family; Many proteins may score above the trusted cutoff because an ...
 597-779 1.02e-54

26S proteasome subunit P45 family; Many proteins may score above the trusted cutoff because an internal


Pssm-ID: 130309 [Multi-domain]  Cd Length: 364  Bit Score: 193.09  E-value: 1.02e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  597 ITLKDFLQAMNDIRPSAMReiAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTM 676
Cdd:TIGR01242  94 LTIVDVLPTSKDPLVKGME--VEERPNVSYEDIGGLEEQIREIREAVELPLKHPELFEEVGIEPPKGVLLYGPPGTGKTL 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  677 IAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFFDELDALAVERGSSLGAGN-VADRVLAQLLT 755
Cdd:TIGR01242 172 LAKAVAHETNATFIRVVGSELVRKYIGEGARLVREIFELAKEKAPSIIFIDEIDAIAAKRTDSGTSGDrEVQRTLMQLLA 251

                         170       180
                  ....*....|....*....|....
gi 767931246  756 EMDGIEQLKDVTILAATNRPDRID 779
Cdd:TIGR01242 252 ELDGFDPRGNVKVIAATNRPDILD 275
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 350-578 1.05e-54

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 193.83  E-value: 1.05e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 350 VTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYG 429
Cdd:PTZ00454 142 VTYSDIGGLDIQKQEIREAVELPLTCPELYEQIGIDPPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEFVQKYLG 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 430 ETEAKLRQIFAEATLRHPSIIFIDELDALCPKR----EGAQNEVEkRVVASLLTLMDGIGSEVSegqVLVLGATNRPHAL 505
Cdd:PTZ00454 222 EGPRMVRDVFRLARENAPSIIFIDEVDSIATKRfdaqTGADREVQ-RILLELLNQMDGFDQTTN---VKVIMATNRADTL 297

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767931246 506 DAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVpHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRR 578
Cdd:PTZ00454 298 DPALLRPGRLDRKIEFPLPDRRQKRLIFQTITSKM-NLSEEVDLEDFVSRPEKISAADIAAICQEAGMQAVRK 369
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 635-779 1.70e-54

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 184.94  E-value: 1.70e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 635 IKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFR 714
Cdd:cd19526    1 VKKALEETIEWPSKYPKIFASSPLRLRSGILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNKYIGASEQNVRDLFS 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767931246 715 KARAVAPSIIFFDELDALAVERG-SSLGagnVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRID 779
Cdd:cd19526   81 RAQSAKPCILFFDEFDSIAPKRGhDSTG---VTDRVVNQLLTQLDGVEGLDGVYVLAATSRPDLID 143
pup_AAA TIGR03689
proteasome ATPase; In the Actinobacteria, as shown for Mycobacterium tuberculosis, some ...
 620-779 5.33e-54

proteasome ATPase; In the Actinobacteria, as shown for Mycobacterium tuberculosis, some proteins are modified by ligation between an epsilon-amino group of a lysine side chain and the C-terminal carboxylate of the ubiquitin-like protein Pup. This modification leads to protein degradation by the archaeal-like proteasome found in the Actinobacteria. Members of this protein family belong to the AAA family of ATPases and tend to be clustered with the genes for Pup, the Pup ligase PafA, and structural components of the proteasome. This protein forms hexameric rings with ATPase activity. [Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 200312 [Multi-domain]  Cd Length: 512  Bit Score: 194.93  E-value: 5.33e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  620 DVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALAN-------ESGLN---F 689
Cdd:TIGR03689 175 EVPDVTYADIGGLGSQIEQIRDAVELPFLHPELYREYGLKPPKGVLLYGPPGCGKTLIAKAVANslaarigAEGGGksyF 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  690 LAIKGPELMNKYVGESERAVRETFRKARAVA----PSIIFFDELDALAVERGSSLgAGNVADRVLAQLLTEMDGIEQLKD 765
Cdd:TIGR03689 255 LNIKGPELLNKYVGETERQIRLIFQRAREKAsegrPVIVFFDEMDSLFRTRGSGV-SSDVETTVVPQLLAEIDGVESLDN 333

                         170
                  ....*....|....
gi 767931246  766 VTILAATNRPDRID 779
Cdd:TIGR03689 334 VIVIGASNREDMID 347
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 355-518 2.40e-53

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 182.32  E-value: 2.40e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 355 IGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVI-----NGPEIISKFYG 429
Cdd:cd19517    2 IGGLSHYINQLKEMVFFPLLYPEVFAKFKITPPRGVLFHGPPGTGKTLMARALAAECSKGGQKVsffmrKGADCLSKWVG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 430 ETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGsevSEGQVLVLGATNRPHALDAAL 509
Cdd:cd19517   82 EAERQLRLLFEEAYRMQPSIIFFDEIDGLAPVRSSKQEQIHASIVSTLLALMDGLD---NRGQVVVIGATNRPDALDPAL 158


                 ....*....
gi 767931246 510 RRPGRFDKE 518
Cdd:cd19517  159 RRPGRFDRE 167
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 332-577 1.57e-52

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 188.83  E-value: 1.57e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 332 VNFTEIDKNSKEqdnqfkvTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEV 411
Cdd:PTZ00361 169 VSVMKVDKAPLE-------SYADIGGLEQQIQEIKEAVELPLTHPELYDDIGIKPPKGVILYGPPGTGKTLLAKAVANET 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 412 GAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEK---RVVASLLTLMDGIGsev 488
Cdd:PTZ00361 242 SATFLRVVGSELIQKYLGDGPKLVRELFRVAEENAPSIVFIDEIDAIGTKRYDATSGGEKeiqRTMLELLNQLDGFD--- 318

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 489 SEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVpHLLTEAELLQLANSAHGYVGADLKVLC 568
Cdd:PTZ00361 319 SRGDVKVIMATNRIESLDPALIRPGRIDRKIEFPNPDEKTKRRIFEIHTSKM-TLAEDVDLEEFIMAKDELSGADIKAIC 397


                 ....*....
gi 767931246 569 NEAGLCALR 577
Cdd:PTZ00361 398 TEAGLLALR 406
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 355-521 2.51e-52

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 179.09  E-value: 2.51e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 355 IGGLSSQLKAIREIIELPLKQPELFKsyGIPA-PRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEA 433
Cdd:cd19509    1 IAGLDDAKEALKEAVILPSLRPDLFP--GLRGpPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 434 KLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGSEvSEGQVLVLGATNRPHALDAALRRpg 513
Cdd:cd19509   79 IVRALFALARELQPSIIFIDEIDSLLSERGSGEHEASRRVKTEFLVQMDGVLNK-PEDRVLVLGATNRPWELDEAFLR-- 155


                 ....*...
gi 767931246 514 RFDKEIEI 521
Cdd:cd19509  156 RFEKRIYI 163
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 624-780 5.10e-52

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 178.58  E-value: 5.10e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 624 VSWSDIGGLESIKLKLEQAVEWpLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVG 703
Cdd:cd19501    1 VTFKDVAGCEEAKEELKEVVEF-LKNPEKFTKLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVG 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767931246 704 ESERAVRETFRKARAVAPSIIFFDELDALAVERGSSLGAGN-VADRVLAQLLTEMDGIEQLKDVTILAATNRPDRIDK 780
Cdd:cd19501   80 VGASRVRDLFEQAKKNAPCIVFIDEIDAVGRKRGAGLGGGHdEREQTLNQLLVEMDGFESNTGVIVIAATNRPDVLDP 157
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 635-780 5.60e-52

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 178.25  E-value: 5.60e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 635 IKLKLEQAVEWPLKHPESFiRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFR 714
Cdd:cd19481    1 LKASLREAVEAPRRGSRLR-RYGLGLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGESEKNLRKIFE 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767931246 715 KARAVAPSIIFFDELDALAVERGSSLGAGnVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRIDK 780
Cdd:cd19481   80 RARRLAPCILFIDEIDAIGRKRDSSGESG-ELRRVLNQLLTELDGVNSRSKVLVIAATNRPDLLDP 144
FtsH_fam TIGR01241
ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct ...
 345-592 1.01e-50

ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 273520 [Multi-domain]  Cd Length: 495  Bit Score: 185.57  E-value: 1.01e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  345 DNQFKVTYDMIGGLSSQLKAIREIIELpLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEII 424
Cdd:TIGR01241  47 EEKPKVTFKDVAGIDEAKEELMEIVDF-LKNPSKFTKLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFV 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  425 SKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKRE----GAQNEVEkRVVASLLTLMDGIGSevSEGqVLVLGATN 500
Cdd:TIGR01241 126 EMFVGVGASRVRDLFEQAKKNAPCIIFIDEIDAVGRQRGaglgGGNDERE-QTLNQLLVEMDGFGT--NTG-VIVIAATN 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  501 RPHALDAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPhLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRRIl 580
Cdd:TIGR01241 202 RPDVLDPALLRPGRFDRQVVVDLPDIKGREEILKVHAKNKK-LAPDVDLKAVARRTPGFSGADLANLLNEAALLAARKN- 279

                         250
                  ....*....|..
gi 767931246  581 KKQPNLPDVKVA 592
Cdd:TIGR01241 280 KTEITMNDIEEA 291
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 620-779 7.48e-50

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 180.34  E-value: 7.48e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 620 DVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMN 699
Cdd:PTZ00454 138 EKPDVTYSDIGGLDIQKQEIREAVELPLTCPELYEQIGIDPPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEFVQ 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 700 KYVGESERAVRETFRKARAVAPSIIFFDELDALAVER-GSSLGAGNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRI 778
Cdd:PTZ00454 218 KYLGEGPRMVRDVFRLARENAPSIIFIDEVDSIATKRfDAQTGADREVQRILLELLNQMDGFDQTTNVKVIMATNRADTL 297


                 .
gi 767931246 779 D 779
Cdd:PTZ00454 298 D 298
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 390-523 7.51e-50

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 171.24  E-value: 7.51e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  390 VLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEV 469
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDSE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767931246  470 EKRVVASLLTLMDGIgsEVSEGQVLVLGATNRPHALDAALRrpGRFDKEIEIGV 523
Cdd:pfam00004  81 SRRVVNQLLTELDGF--TSSNSKVIVIAATNRPDKLDPALL--GRFDRIIEFPL 130
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 362-517 8.83e-50

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 172.29  E-value: 8.83e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 362 LKAIREIIEL----PLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQ 437
Cdd:cd19530    1 LDHVREELTMsilrPIKRPDIYKALGIDLPTGVLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGESERAVRQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 438 IFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGsevSEGQVLVLGATNRPHALDAALRRPGRFDK 517
Cdd:cd19530   81 VFQRARASAPCVIFFDEVDALVPKRGDGGSWASERVVNQLLTEMDGLE---ERSNVFVIAATNRPDIIDPAMLRPGRLDK 157
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 635-779 1.48e-47

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 165.76  E-value: 1.48e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 635 IKLKLEQAVEWPLKHPESFiRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFR 714
Cdd:cd19527    1 VKKEILDTIQLPLEHPELF-SSGLRKRSGILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEANVREVFQ 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767931246 715 KARAVAPSIIFFDELDALAVERGSSLGAGNVADRVLAQLLTEMDGIEQ-LKDVTILAATNRPDRID 779
Cdd:cd19527   80 KARDAKPCVIFFDELDSLAPSRGNSGDSGGVMDRVVSQLLAELDGMSSsGQDVFVIGATNRPDLLD 145
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 365-521 1.31e-46

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 163.45  E-value: 1.31e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 365 IREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATL 444
Cdd:cd19528    5 LQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDKARA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 445 RHPSIIFIDELDALCPKREGA---QNEVEKRVVASLLTLMDGIGSEVSegqVLVLGATNRPHALDAALRRPGRFDKEIEI 521
Cdd:cd19528   85 AAPCVLFFDELDSIAKARGGNigdAGGAADRVINQILTEMDGMNTKKN---VFIIGATNRPDIIDPAILRPGRLDQLIYI 161
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
349-605 1.64e-46

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 175.23  E-value: 1.64e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 349 KVTYDMIGGLSSQLKAIREIIELpLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGayvsV----INGPEII 424
Cdd:COG0465  138 KVTFDDVAGVDEAKEELQEIVDF-LKDPEKFTRLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAG----VpffsISGSDFV 212

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 425 SKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKReGA--------------QnevekrvvasLLTLMDGIgsEVSE 490
Cdd:COG0465  213 EMFVGVGASRVRDLFEQAKKNAPCIIFIDEIDAVGRQR-GAglggghdereqtlnQ----------LLVEMDGF--EGNE 279

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 491 GqVLVLGATNRPHALDAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPhLLTEAELLQLANSAHGYVGADLKVLCNE 570
Cdd:COG0465  280 G-VIVIAATNRPDVLDPALLRPGRFDRQVVVDLPDVKGREAILKVHARKKP-LAPDVDLEVIARRTPGFSGADLANLVNE 357

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 767931246 571 AGLCALRRilkkqpnlpdvkvaGLVKITLKDFLQA 605
Cdd:COG0465  358 AALLAARR--------------NKKAVTMEDFEEA 378
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 629-779 7.35e-46

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 161.37  E-value: 7.35e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 629 IGGLESIKLKLEQAVEWPLKHPESFiRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERA 708
Cdd:cd19509    1 IAGLDDAKEALKEAVILPSLRPDLF-PGLRGPPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEKI 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767931246 709 VRETFRKARAVAPSIIFFDELDALAVERGSslGAGNVADRVLAQLLTEMDGIE--QLKDVTILAATNRPDRID 779
Cdd:cd19509   80 VRALFALARELQPSIIFIDEIDSLLSERGS--GEHEASRRVKTEFLVQMDGVLnkPEDRVLVLGATNRPWELD 150
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 350-521 4.48e-45

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 159.32  E-value: 4.48e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 350 VTYDMIGGLSSQLKAIREIIELpLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYG 429
Cdd:cd19501    1 VTFKDVAGCEEAKEELKEVVEF-LKNPEKFTKLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 430 ETEAKLRQIFAEATLRHPSIIFIDELDALCPKR---EGAQNEVEKRVVASLLTLMDGIGSEVsegQVLVLGATNRPHALD 506
Cdd:cd19501   80 VGASRVRDLFEQAKKNAPCIVFIDEIDAVGRKRgagLGGGHDEREQTLNQLLVEMDGFESNT---GVIVIAATNRPDVLD 156

                        170
                 ....*....|....*
gi 767931246 507 AALRRPGRFDKEIEI 521
Cdd:cd19501  157 PALLRPGRFDRQVYV 171
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 628-779 5.40e-45

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 159.11  E-value: 5.40e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 628 DIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESER 707
Cdd:cd19518    1 DIGGMDSTLKELCELLIHPILPPEYFQHLGVEPPRGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGESEE 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767931246 708 AVRETFRKARAVAPSIIFFDELDALAVERGSSlgAGNVADRVLAQLLTEMDGIEQLKD----VTILAATNRPDRID 779
Cdd:cd19518   81 KIRELFDQAISNAPCIVFIDEIDAITPKRESA--QREMERRIVSQLLTCMDELNNEKTaggpVLVIGATNRPDSLD 154
ftsH CHL00176
cell division protein; Validated
 350-609 5.60e-45

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 171.77  E-value: 5.60e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 350 VTYDMIGGLSSQLKAIREIIELpLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYG 429
Cdd:CHL00176 180 ITFRDIAGIEEAKEEFEEVVSF-LKKPERFTAVGAKIPKGVLLVGPPGTGKTLLAKAIAGEAEVPFFSISGSEFVEMFVG 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 430 ETEAKLRQIFAEATLRHPSIIFIDELDALCPKR----EGAQNEVEKrVVASLLTLMDGIgsEVSEGqVLVLGATNRPHAL 505
Cdd:CHL00176 259 VGAARVRDLFKKAKENSPCIVFIDEIDAVGRQRgagiGGGNDEREQ-TLNQLLTEMDGF--KGNKG-VIVIAATNRVDIL 334

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 506 DAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPhLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRRilkkqpn 585
Cdd:CHL00176 335 DAALLRPGRFDRQITVSLPDREGRLDILKVHARNKK-LSPDVSLELIARRTPGFSGADLANLLNEAAILTARR------- 406

                        250       260
                 ....*....|....*....|....
gi 767931246 586 lpdvkvaGLVKITLKDFLQAMNDI 609
Cdd:CHL00176 407 -------KKATITMKEIDTAIDRV 423
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 664-780 8.55e-45

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 156.98  E-value: 8.55e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  664 VLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFFDELDALAVERGSslGAG 743
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGS--GGD 78

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 767931246  744 NVADRVLAQLLTEMDGIEQLKD-VTILAATNRPDRIDK 780
Cdd:pfam00004  79 SESRRVVNQLLTELDGFTSSNSkVIVIAATNRPDKLDP 116
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 363-520 2.28e-44

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 156.82  E-value: 2.28e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 363 KAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEA 442
Cdd:cd19526    3 KALEETIEWPSKYPKIFASSPLRLRSGILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNKYIGASEQNVRDLFSRA 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767931246 443 TLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIgsEVSEGqVLVLGATNRPHALDAALRRPGRFDKEIE 520
Cdd:cd19526   83 QSAKPCILFFDEFDSIAPKRGHDSTGVTDRVVNQLLTQLDGV--EGLDG-VYVLAATSRPDLIDPALLRPGRLDKLVY 157
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 349-521 8.15e-44

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 155.79  E-value: 8.15e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 349 KVTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPApRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFY 428
Cdd:cd19521    3 NVKWEDVAGLEGAKEALKEAVILPVKFPHLFTGNRKPW-SGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWM 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 429 GETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGSEvSEGqVLVLGATNRPHALDAA 508
Cdd:cd19521   82 GESEKLVKQLFAMARENKPSIIFIDEVDSLCGTRGEGESEASRRIKTELLVQMNGVGND-SQG-VLVLGATNIPWQLDSA 159

                        170
                 ....*....|...
gi 767931246 509 LRRpgRFDKEIEI 521
Cdd:cd19521  160 IRR--RFEKRIYI 170
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 622-780 1.60e-43

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 163.40  E-value: 1.60e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 622 PNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKY 701
Cdd:PTZ00361 178 PLESYADIGGLEQQIQEIKEAVELPLTHPELYDDIGIKPPKGVILYGPPGTGKTLLAKAVANETSATFLRVVGSELIQKY 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 702 VGESERAVRETFRKARAVAPSIIFFDELDALAVER--GSSLGAGNVaDRVLAQLLTEMDGIEQLKDVTILAATN------ 773
Cdd:PTZ00361 258 LGDGPKLVRELFRVAEENAPSIVFIDEIDAIGTKRydATSGGEKEI-QRTMLELLNQLDGFDSRGDVKVIMATNriesld 336

                        170
                 ....*....|.
gi 767931246 774 ----RPDRIDK 780
Cdd:PTZ00361 337 paliRPGRIDR 347
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
345-577 1.95e-43

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 167.13  E-value: 1.95e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 345 DNQFKVTYDMIGGLSSQLKAIREIIELpLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEII 424
Cdd:PRK10733 144 EDQIKTTFADVAGCDEAKEEVAELVEY-LREPSRFQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFV 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 425 SKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKRE---GAQNEVEKRVVASLLTLMDGIgsEVSEGqVLVLGATNR 501
Cdd:PRK10733 223 EMFVGVGASRVRDMFEQAKKAAPCIIFIDEIDAVGRQRGaglGGGHDEREQTLNQMLVEMDGF--EGNEG-IIVIAATNR 299

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767931246 502 PHALDAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPhLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALR 577
Cdd:PRK10733 300 PDVLDPALLRPGRFDRQVVVGLPDVRGREQILKVHMRRVP-LAPDIDAAIIARGTPGFSGADLANLVNEAALFAAR 374
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 363-517 9.65e-43

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 152.28  E-value: 9.65e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 363 KAIREIIELPLKQPELFKSyGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEA 442
Cdd:cd19527    3 KEILDTIQLPLEHPELFSS-GLRKRSGILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEANVREVFQKA 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767931246 443 TLRHPSIIFIDELDALCPKR--EGAQNEVEKRVVASLLTLMDGIGSevSEGQVLVLGATNRPHALDAALRRPGRFDK 517
Cdd:cd19527   82 RDAKPCVIFFDELDSLAPSRgnSGDSGGVMDRVVSQLLAELDGMSS--SGQDVFVIGATNRPDLLDPALLRPGRFDK 156
FtsH_fam TIGR01241
ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct ...
 602-780 3.15e-42

ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 273520 [Multi-domain]  Cd Length: 495  Bit Score: 160.91  E-value: 3.15e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  602 FLQAMNDIRPSAM-------REIAIDVPNVSWSDIGGLESIKLKLEQAVEWpLKHPESFIRMGIQPPKGVLLYGPPGCSK 674
Cdd:TIGR01241  23 FRRQMQGGGGRAFsfgkskaKLLNEEKPKVTFKDVAGIDEAKEELMEIVDF-LKNPSKFTKLGAKIPKGVLLVGPPGTGK 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  675 TMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFFDELDALAVERGSSLGAGN-VADRVLAQL 753
Cdd:TIGR01241 102 TLLAKAVAGEAGVPFFSISGSDFVEMFVGVGASRVRDLFEQAKKNAPCIIFIDEIDAVGRQRGAGLGGGNdEREQTLNQL 181

                         170       180
                  ....*....|....*....|....*..
gi 767931246  754 LTEMDGIEQLKDVTILAATNRPDRIDK 780
Cdd:TIGR01241 182 LVEMDGFGTNTGVIVIAATNRPDVLDP 208
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 350-521 4.43e-42

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 151.68  E-value: 4.43e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 350 VTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPaPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYG 429
Cdd:cd19525   19 INWADIAGLEFAKKTIKEIVVWPMLRPDIFTGLRGP-PKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 430 ETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGSEvSEGQVLVLGATNRPHALDAAL 509
Cdd:cd19525   98 EGEKMVRALFSVARCKQPAVIFIDEIDSLLSQRGEGEHESSRRIKTEFLVQLDGATTS-SEDRILVVGATNRPQEIDEAA 176

                        170
                 ....*....|..
gi 767931246 510 RRpgRFDKEIEI 521
Cdd:cd19525  177 RR--RLVKRLYI 186
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 355-521 5.47e-40

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 145.13  E-value: 5.47e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 355 IGGLSSQLKAIREIIELPLKQPELFKsyGIPAP-RGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEA 433
Cdd:cd19522    2 IADLEEAKKLLEEAVVLPMWMPEFFK--GIRRPwKGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRGESEK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 434 KLRQIFAEATLRHPSIIFIDELDALCPKR-EGAQNEVEKRVVASLLTLMDGI-GSEVSEGQ---VLVLGATNRPHALDAA 508
Cdd:cd19522   80 LVRLLFEMARFYAPTTIFIDEIDSICSRRgTSEEHEASRRVKSELLVQMDGVgGASENDDPskmVMVLAATNFPWDIDEA 159

                        170
                 ....*....|...
gi 767931246 509 LRRpgRFDKEIEI 521
Cdd:cd19522  160 LRR--RLEKRIYI 170
ftsH CHL00176
cell division protein; Validated
 624-779 6.55e-40

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 156.75  E-value: 6.55e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 624 VSWSDIGGLESIKLKLEQAVEWpLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVG 703
Cdd:CHL00176 180 ITFRDIAGIEEAKEEFEEVVSF-LKKPERFTAVGAKIPKGVLLVGPPGTGKTLLAKAIAGEAEVPFFSISGSEFVEMFVG 258

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767931246 704 ESERAVRETFRKARAVAPSIIFFDELDALAVERGSSLGAGN-VADRVLAQLLTEMDGIEQLKDVTILAATNRPDRID 779
Cdd:CHL00176 259 VGAARVRDLFKKAKENSPCIVFIDEIDAVGRQRGAGIGGGNdEREQTLNQLLTEMDGFKGNKGVIVIAATNRVDILD 335
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 355-515 8.63e-40

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 144.49  E-value: 8.63e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 355 IGGLSSQLKAIREIIELPLKQPELFKSYGI-PAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEA 433
Cdd:cd19520    2 IGGLDEVITELKELVILPLQRPELFDNSRLlQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 434 KLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGSEVSEgQVLVLGATNRPHALDAALRR-- 511
Cdd:cd19520   82 LVAAVFSLASKLQPSIIFIDEIDSFLRQRSSTDHEATAMMKAEFMSLWDGLSTDGNC-RVIVMGATNRPQDLDEAILRrm 160


                 ....
gi 767931246 512 PGRF 515
Cdd:cd19520  161 PKRF 164
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 628-779 2.17e-39

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 143.42  E-value: 2.17e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 628 DIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESG-----LNFLAIKGPELMNKYV 702
Cdd:cd19517    1 DIGGLSHYINQLKEMVFFPLLYPEVFAKFKITPPRGVLFHGPPGTGKTLMARALAAECSkggqkVSFFMRKGADCLSKWV 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767931246 703 GESERAVRETFRKARAVAPSIIFFDELDALAVERGSSlgAGNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRID 779
Cdd:cd19517   81 GEAERQLRLLFEEAYRMQPSIIFFDEIDGLAPVRSSK--QEQIHASIVSTLLALMDGLDNRGQVVVIGATNRPDALD 155
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
626-780 3.09e-39

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 145.41  E-value: 3.09e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 626 WSDIGGLESIKLKLEQAVEWpLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGES 705
Cdd:COG1223    1 LDDVVGQEEAKKKLKLIIKE-LRRRENLRKFGLWPPRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSLIGSYLGET 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767931246 706 ERAVRETFRKARAvAPSIIFFDELDALAVERGSSLGAGNVAdRVLAQLLTEMDGIEQlkDVTILAATNRPDRIDK 780
Cdd:COG1223   80 ARNLRKLFDFARR-APCVIFFDEFDAIAKDRGDQNDVGEVK-RVVNALLQELDGLPS--GSVVIAATNHPELLDS 150
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 614-780 4.88e-39

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 142.82  E-value: 4.88e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 614 MREIAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFirMGIQ-PPKGVLLYGPPGCSKTMIAKALANESGLNFLAI 692
Cdd:cd19525    9 MSEIMDHGPPINWADIAGLEFAKKTIKEIVVWPMLRPDIF--TGLRgPPKGILLFGPPGTGKTLIGKCIASQSGATFFSI 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 693 KGPELMNKYVGESERAVRETFRKARAVAPSIIFFDELDALAVERGSslGAGNVADRVLAQLLTEMDGIEQLKD--VTILA 770
Cdd:cd19525   87 SASSLTSKWVGEGEKMVRALFSVARCKQPAVIFIDEIDSLLSQRGE--GEHESSRRIKTEFLVQLDGATTSSEdrILVVG 164

                        170
                 ....*....|
gi 767931246 771 ATNRPDRIDK 780
Cdd:cd19525  165 ATNRPQEIDE 174
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 628-780 8.43e-39

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 141.41  E-value: 8.43e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 628 DIGGLESIKLKLEQAVEWPLKHPESFIRMGI-QPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESE 706
Cdd:cd19520    1 DIGGLDEVITELKELVILPLQRPELFDNSRLlQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQ 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767931246 707 RAVRETFRKARAVAPSIIFFDELDALAVERGSSlgAGNVADRVLAQLLTEMDGI--EQLKDVTILAATNRPDRIDK 780
Cdd:cd19520   81 KLVAAVFSLASKLQPSIIFIDEIDSFLRQRSST--DHEATAMMKAEFMSLWDGLstDGNCRVIVMGATNRPQDLDE 154
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 628-780 1.26e-38

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 141.28  E-value: 1.26e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 628 DIGGLESIKLKLEQAVEWPLKHPESFirMGIQPP-KGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESE 706
Cdd:cd19522    1 DIADLEEAKKLLEEAVVLPMWMPEFF--KGIRRPwKGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRGESE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 707 RAVRETFRKARAVAPSIIFFDELDALAVERGSSlGAGNVADRVLAQLLTEMDGI-------EQLKDVTILAATNRPDRID 779
Cdd:cd19522   79 KLVRLLFEMARFYAPTTIFIDEIDSICSRRGTS-EEHEASRRVKSELLVQMDGVggasendDPSKMVMVLAATNFPWDID 157


                 .
gi 767931246 780 K 780
Cdd:cd19522  158 E 158
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
622-776 2.11e-38

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 151.34  E-value: 2.11e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 622 PNVSWSDIGGLESIKLKLEQAVEWpLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKY 701
Cdd:COG0465  137 PKVTFDDVAGVDEAKEELQEIVDF-LKDPEKFTRLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMF 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 702 VG--ESeRaVRETFRKARAVAPSIIFFDELDALAVERGSSLGAGNvaD---RVLAQLLTEMDGIEQLKDVTILAATNRPD 776
Cdd:COG0465  216 VGvgAS-R-VRDLFEQAKKNAPCIIFIDEIDAVGRQRGAGLGGGH--DereQTLNQLLVEMDGFEGNEGVIVIAATNRPD 291
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 622-779 1.12e-37

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 138.46  E-value: 1.12e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 622 PNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRmGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKY 701
Cdd:cd19521    2 PNVKWEDVAGLEGAKEALKEAVILPVKFPHLFTG-NRKPWSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKW 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767931246 702 VGESERAVRETFRKARAVAPSIIFFDELDALAVERGSslGAGNVADRVLAQLLTEMDGIEQLKD-VTILAATNRPDRID 779
Cdd:cd19521   81 MGESEKLVKQLFAMARENKPSIIFIDEVDSLCGTRGE--GESEASRRIKTELLVQMNGVGNDSQgVLVLGATNIPWQLD 157
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 355-511 2.89e-36

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 134.21  E-value: 2.89e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 355 IGGLSSQLKAIREIIELPLKQPELFKSYGIPaPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAK 434
Cdd:cd19524    2 IAGQDLAKQALQEMVILPSLRPELFTGLRAP-ARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767931246 435 LRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGSEvSEGQVLVLGATNRPHALD-AALRR 511
Cdd:cd19524   81 VRALFAVARELQPSIIFIDEVDSLLSERSEGEHEASRRLKTEFLIEFDGVQSN-GDDRVLVMGATNRPQELDdAVLRR 157
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
 355-521 1.56e-35

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 132.61  E-value: 1.56e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 355 IGGLSSQLKAI-REIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAY-VSVINGPEIISKFYGETE 432
Cdd:cd19504    2 IGGLDKEFSDIfRRAFASRVFPPEIVEQLGCKHVKGILLYGPPGTGKTLMARQIGKMLNARePKIVNGPEILNKYVGESE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 433 AKLRQIFAEATLRHPS--------IIFIDELDALCPKREGAQNE--VEKRVVASLLTLMDGIGsevSEGQVLVLGATNRP 502
Cdd:cd19504   82 ANIRKLFADAEEEQRRlgansglhIIIFDEIDAICKQRGSMAGStgVHDTVVNQLLSKIDGVE---QLNNILVIGMTNRK 158

                        170
                 ....*....|....*....
gi 767931246 503 HALDAALRRPGRFDKEIEI 521
Cdd:cd19504  159 DLIDEALLRPGRLEVQMEI 177
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
612-779 4.41e-34

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 139.01  E-value: 4.41e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 612 SAMREIAIDVPNVSWSDIGGLESIKLKLEQAVEWpLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLA 691
Cdd:PRK10733 137 SKARMLTEDQIKTTFADVAGCDEAKEEVAELVEY-LREPSRFQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFT 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 692 IKGPELMNKYVGESERAVRETFRKARAVAPSIIFFDELDALAVERGSSLGAG-NVADRVLAQLLTEMDGIEQLKDVTILA 770
Cdd:PRK10733 216 ISGSDFVEMFVGVGASRVRDMFEQAKKAAPCIIFIDEIDAVGRQRGAGLGGGhDEREQTLNQMLVEMDGFEGNEGIIVIA 295


                 ....*....
gi 767931246 771 ATNRPDRID 779
Cdd:PRK10733 296 ATNRPDVLD 304
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
 650-779 3.40e-33

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 126.07  E-value: 3.40e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 650 PESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANE-SGLNFLAIKGPELMNKYVGESERAVRETFRKA----RAVAPS-- 722
Cdd:cd19504   24 PEIVEQLGCKHVKGILLYGPPGTGKTLMARQIGKMlNAREPKIVNGPEILNKYVGESEANIRKLFADAeeeqRRLGANsg 103

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767931246 723 --IIFFDELDALAVERGSSLGAGNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRID 779
Cdd:cd19504  104 lhIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRKDLID 162
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 628-779 1.52e-32

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 123.81  E-value: 1.52e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 628 DIGGLESIKLKLEQAVEWPLKHPESFIRMGiQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESER 707
Cdd:cd19524    1 DIAGQDLAKQALQEMVILPSLRPELFTGLR-APARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEK 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767931246 708 AVRETFRKARAVAPSIIFFDELDALAVERGSslGAGNVADRVLAQLLTEMDGIEQLKD--VTILAATNRPDRID 779
Cdd:cd19524   80 LVRALFAVARELQPSIIFIDEVDSLLSERSE--GEHEASRRLKTEFLIEFDGVQSNGDdrVLVMGATNRPQELD 151
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 355-521 3.64e-27

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 108.05  E-value: 3.64e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 355 IGGLSSQLKAIREIIELPLKQPELFKSYGIPaPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAK 434
Cdd:cd19523    2 IAGLGALKAAIKEEVLWPLLRPDAFSGLLRL-PRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEKI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 435 LRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGSevSEGQVLVLGATNRPHALDAALRRpgR 514
Cdd:cd19523   81 LQASFLAARCRQPSVLFISDLDALLSSQDDEASPVGRLQVELLAQLDGVLGS--GEDGVLVVCTTSKPEEIDESLRR--Y 156


                 ....*..
gi 767931246 515 FDKEIEI 521
Cdd:cd19523  157 FSKRLLV 163
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
 628-783 9.21e-26

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 103.99  E-value: 9.21e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 628 DIGGLESIKlkleqavEWPLKHPESF----IRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVG 703
Cdd:cd19507    1 DVGGLDNLK-------DWLKKRKAAFskqaSAYGLPTPKGLLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGGLVG 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 704 ESERAVRETFRKARAVAPSIIFFDELDAlAVERGSSLGAGNVADRVLAQLLTEMDgiEQLKDVTILAATNrpdRIDKVPP 783
Cdd:cd19507   74 ESESRLRQMIQTAEAIAPCVLWIDEIEK-GFSNADSKGDSGTSSRVLGTFLTWLQ--EKKKPVFVVATAN---NVQSLPP 147
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 628-780 1.99e-24

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 100.34  E-value: 1.99e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 628 DIGGLESIKLKLEQAVEWPLKHPESFIRMgIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESER 707
Cdd:cd19523    1 DIAGLGALKAAIKEEVLWPLLRPDAFSGL-LRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEK 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767931246 708 AVRETFRKARAVAPSIIFFDELDALAVERGSSLGAGNvadRVLAQLLTEMDGI--EQLKDVTILAATNRPDRIDK 780
Cdd:cd19523   80 ILQASFLAARCRQPSVLFISDLDALLSSQDDEASPVG---RLQVELLAQLDGVlgSGEDGVLVVCTTSKPEEIDE 151
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 385-522 3.22e-24

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 99.53  E-value: 3.22e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 385 PAPRGVLLYGPPGTGKTMIARAVANEV---GAYVSVINGPEIISKFYGETEAK---LRQIFAEATLRHPSIIFIDELDAL 458
Cdd:cd00009   17 PPPKNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASDLLEGLVVAELFGhflVRLLFELAEKAKPGVLFIDEIDSL 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767931246 459 cpkREGAQNEVekrvvasLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIG 522
Cdd:cd00009   97 ---SRGAQNAL-------LRVLETLNDLRIDRENVRVIGATNRPLLGDLDRALYDRLDIRIVIP 150
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 630-783 9.25e-23

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 95.29  E-value: 9.25e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 630 GGLESIKLKLEQAVEWPlkhpesfirmgiqPPKGVLLYGPPGCSKTMIAKALANES---GLNFLAIKGPELMNKYVGESE 706
Cdd:cd00009    1 VGQEEAIEALREALELP-------------PPKNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASDLLEGLVVAEL 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 707 R---AVRETFRKARAVAPSIIFFDELDALAVErgsslgagnVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRIDKVPP 783
Cdd:cd00009   68 FghfLVRLLFELAEKAKPGVLFIDEIDSLSRG---------AQNALLRVLETLNDLRIDRENVRVIGATNRPLLGDLDRA 138
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
 380-516 1.12e-20

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 89.35  E-value: 1.12e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 380 KSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELD-AL 458
Cdd:cd19507   24 SAYGLPTPKGLLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGGLVGESESRLRQMIQTAEAIAPCVLWIDEIEkGF 103

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767931246 459 CPKREGAQNEVEKRVVASLLTLMdgigSEVSEgQVLVLGATNRPHALDAALRRPGRFD 516
Cdd:cd19507  104 SNADSKGDSGTSSRVLGTFLTWL----QEKKK-PVFVVATANNVQSLPPELLRKGRFD 156
ycf46 CHL00195
Ycf46; Provisional
 380-565 1.68e-17

Ycf46; Provisional


Pssm-ID: 177094 [Multi-domain]  Cd Length: 489  Bit Score: 86.23  E-value: 1.68e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 380 KSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQI--FAEATlrHPSIIFIDELD- 456
Cdd:CHL00195 252 SNYGLPTPRGLLLVGIQGTGKSLTAKAIANDWQLPLLRLDVGKLFGGIVGESESRMRQMirIAEAL--SPCILWIDEIDk 329

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 457 ALCPKREGAQNEVEKRVVASLLTLMdgigSEvSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPNAQDRLDILQKL 536
Cdd:CHL00195 330 AFSNSESKGDSGTTNRVLATFITWL----SE-KKSPVFVVATANNIDLLPLEILRKGRFDEIFFLDLPSLEEREKIFKIH 404

                        170       180       190
                 ....*....|....*....|....*....|
gi 767931246 537 LRRV-PHLLTEAELLQLANSAHGYVGADLK 565
Cdd:CHL00195 405 LQKFrPKSWKKYDIKKLSKLSNKFSGAEIE 434
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 365-521 2.09e-17

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 79.70  E-value: 2.09e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 365 IREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIiskfyGETEAKLRQIFAEATL 444
Cdd:cd19510    1 IIDDLKDFIKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAGELDYDICDLNLSEV-----VLTDDRLNHLLNTAPK 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 445 RhpSIIFIDELDA------LCPKREGAQNEVEKRVVASLLTLMDGIGSevSEGQVLVLgATNRPHALDAALRRPGRFDKE 518
Cdd:cd19510   76 Q--SIILLEDIDAafesreHNKKNPSAYGGLSRVTFSGLLNALDGVAS--SEERIVFM-TTNHIERLDPALIRPGRVDMK 150


                 ...
gi 767931246 519 IEI 521
Cdd:cd19510  151 IYM 153
ycf46 CHL00195
Ycf46; Provisional
 622-783 2.30e-16

Ycf46; Provisional


Pssm-ID: 177094 [Multi-domain]  Cd Length: 489  Bit Score: 82.76  E-value: 2.30e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 622 PNVSWSDIGGLESIKlkleqavEWPLKHPESF----IRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPEL 697
Cdd:CHL00195 223 VNEKISDIGGLDNLK-------DWLKKRSTSFskqaSNYGLPTPRGLLLVGIQGTGKSLTAKAIANDWQLPLLRLDVGKL 295

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 698 MNKYVGESERAVRETFRKARAVAPSIIFFDELDAlAVERGSSLGAGNVADRVLAQLLTEMDgiEQLKDVTILAATNrpdR 777
Cdd:CHL00195 296 FGGIVGESESRMRQMIRIAEALSPCILWIDEIDK-AFSNSESKGDSGTTNRVLATFITWLS--EKKSPVFVVATAN---N 369


                 ....*.
gi 767931246 778 IDKVPP 783
Cdd:CHL00195 370 IDLLPL 375
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 387-525 1.54e-15

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 74.33  E-value: 1.54e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246   387 PRGVLLYGPPGTGKTMIARAVANEVGAY---VSVINGPEI--------------ISKFYGETEAKLRQIFAEATLRHPSI 449
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPgggVIYIDGEDIleevldqllliivgGKKASGSGELRLRLALALARKLKPDV 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767931246   450 IFIDELDALCPKREGAQNEVEKRVVAslltlmdgIGSEVSEGQVLVLGATNRPHALDAALRRPgRFDKEIEIGVPN 525
Cdd:smart00382  82 LILDEITSLLDAEQEALLLLLEELRL--------LLLLKSEKNLTVILTTNDEKDLGPALLRR-RFDRRIVLLLIL 148
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
 388-520 3.62e-13

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 67.55  E-value: 3.62e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 388 RGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEiISKFYGETEAKLRQIFAEA-TLRHPSIIFIDELDALCPKRegAQ 466
Cdd:cd19512   23 RNILFYGPPGTGKTLFAKKLALHSGMDYAIMTGGD-VAPMGREGVTAIHKVFDWAnTSRRGLLLFVDEADAFLRKR--ST 99

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767931246 467 NEVEKRVVASLLTLMDGIGsEVSEGQVLVLgATNRPHALDAALRrpGRFDKEIE 520
Cdd:cd19512  100 EKISEDLRAALNAFLYRTG-EQSNKFMLVL-ASNQPEQFDWAIN--DRIDEMVE 149
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 660-780 1.22e-12

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 66.24  E-value: 1.22e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246   660 PPKGVLLYGPPGCSKTMIAKALANESGLN---FLAIKGPELM--------------NKYVGESERAVRETFRKARAVAPS 722
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPgggVIYIDGEDILeevldqllliivggKKASGSGELRLRLALALARKLKPD 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 767931246   723 IIFFDELDALavergssLGAGNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRIDK 780
Cdd:smart00382  81 VLILDEITSL-------LDAEQEALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGP 131
T7SS_EccA TIGR03922
type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the ...
 361-520 1.28e-10

type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccA1, EccA2, etc. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 188437 [Multi-domain]  Cd Length: 557  Bit Score: 64.87  E-value: 1.28e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  361 QLKAIREIIELPLKQPElfksYGIPAP---RGVLLYGPPGTGKTMIARAVANEVgAYVSVINGPEI--------ISKFYG 429
Cdd:TIGR03922 287 QVAALKSSTAMALARAE----RGLPVAqtsNHMLFAGPPGTGKTTIARVVAKIY-CGLGVLRKPLVrevsradlIGQYIG 361

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  430 ETEAKLRQIFAEATLRhpsIIFIDELDALCPKREGAQNEVEKRVVASLLTLMdgigsEVSEGQVLVLGATNRpHALDAAL 509
Cdd:TIGR03922 362 ESEAKTNEIIDSALGG---VLFLDEAYTLVETGYGQKDPFGLEAIDTLLARM-----ENDRDRLVVIGAGYR-KDLDKFL 432

                         170
                  ....*....|....*
gi 767931246  510 R-RPG---RFDKEIE 520
Cdd:TIGR03922 433 EvNEGlrsRFTRVIE 447
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
 664-780 6.65e-10

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 59.38  E-value: 6.65e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 664 VLLYGPPGCSKTMIAKALANESGLN---------FLAIKGPELMNKYVGESERAVRETFRKARAVA--PSIIFF---DEL 729
Cdd:cd19508   55 VLLHGPPGTGKTSLCKALAQKLSIRlssryrygqLIEINSHSLFSKWFSESGKLVTKMFQKIQELIddKDALVFvliDEV 134

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767931246 730 DALAVERGSSLGAGNVAD--RVLAQLLTEMDGIEQLKDVTILAATNRPDRIDK 780
Cdd:cd19508  135 ESLAAARSASSSGTEPSDaiRVVNAVLTQIDRIKRYHNNVILLTSNLLEKIDV 187
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 390-558 1.12e-09

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 61.23  E-value: 1.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 390 VLLYGPPGTGKTMIARAVANEVGAYVSVINGpeIISkfygeTEAKLRQIFAEATLRH----PSIIFIDEL--------DA 457
Cdd:COG2256   52 MILWGPPGTGKTTLARLIANATDAEFVALSA--VTS-----GVKDIREVIEEARERRaygrRTILFVDEIhrfnkaqqDA 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 458 LCPkregaqnEVEKRVVasllTLmdgIGS-------EV-----SEGQVLVLgatnrpHALDaalrrpgrfDKEIEIGVPN 525
Cdd:COG2256  125 LLP-------HVEDGTI----TL---IGAttenpsfEVnsallSRCRVFVL------KPLS---------EEDLEQLLER 175

                        170       180       190
                 ....*....|....*....|....*....|...
gi 767931246 526 AqdrLDILQKLLRRVPHLLTEAELLQLANSAHG 558
Cdd:COG2256  176 A---LADDERGLGGYKLELDDEALEALARLADG 205
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 390-558 1.69e-09

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 60.48  E-value: 1.69e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 390 VLLYGPPGTGKTMIARAVANEVGAYVSVINGpeIISKFygeteAKLRQIFAEATLRHPS----IIFIDEL--------DA 457
Cdd:PRK13342  39 MILWGPPGTGKTTLARIIAGATDAPFEALSA--VTSGV-----KDLREVIEEARQRRSAgrrtILFIDEIhrfnkaqqDA 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 458 LCPKregaqneVEKrvvaslltlmdgigsevseGQVLVLGAT--NRPHALDAALR---RPGRF----DKEIEIGVPNAqd 528
Cdd:PRK13342 112 LLPH-------VED-------------------GTITLIGATteNPSFEVNPALLsraQVFELkplsEEDIEQLLKRA-- 163

                        170       180       190
                 ....*....|....*....|....*....|
gi 767931246 529 rldiLQKLLRRVPHLLTEAeLLQLANSAHG 558
Cdd:PRK13342 164 ----LEDKERGLVELDDEA-LDALARLANG 188
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
 388-509 4.88e-09

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 57.07  E-value: 4.88e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 388 RGVLLYGPPGTGKTMIARAVANEVGAYVSV---------INGPEIISKFYGETE---AKLRQIFAEATLRHPSIIF--ID 453
Cdd:cd19508   53 RLVLLHGPPGTGKTSLCKALAQKLSIRLSSryrygqlieINSHSLFSKWFSESGklvTKMFQKIQELIDDKDALVFvlID 132

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 454 ELDALCPKREGAQNEVEK----RVVASLLTLMDGIGSEVSegqVLVLGATNRPHALDAAL 509
Cdd:cd19508  133 EVESLAAARSASSSGTEPsdaiRVVNAVLTQIDRIKRYHN---NVILLTSNLLEKIDVAF 189
RecA-like_IQCA1 cd19506
ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein ...
 385-506 1.38e-08

ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein regulatory complex subunit 11, DRC11 and IQCA) is an ATPase subunit of the nexin-dynein regulatory complex (N-DRC). The 9 + 2 axoneme of most motile cilia and flagella consists of nine outer doublet microtubules arranged in a ring surrounding a central pair of two singlet microtubules. The N-DRC complex maintains alignment between outer doublet microtubules and limits microtubule sliding in motile axonemes. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410914 [Multi-domain]  Cd Length: 160  Bit Score: 54.84  E-value: 1.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 385 PAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGET--EAKLRQIFAEATLRHPSIIFIDELDAL---- 458
Cdd:cd19506   24 PLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGKYPGKNglQMMLHLVLKVARQLQPSVIWIGDAEKTfykk 103

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 767931246 459 CPKREGAQNevEKRVVASLLTLMDGIGsevSEGQVLVLGATNRPHALD 506
Cdd:cd19506  104 VPKTEKQLD--PKRLKKDLPKILKSLK---PEDRVLIVGTTSRPFEAD 146
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
 662-779 1.42e-08

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 54.45  E-value: 1.42e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 662 KGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPEL--MNKyvgESERAVRETFRKARAVAPSIIFF-DELDALAVERgS 738
Cdd:cd19512   23 RNILFYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVapMGR---EGVTAIHKVFDWANTSRRGLLLFvDEADAFLRKR-S 98

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 767931246 739 SLGAGNVADRVLAQLLTEMDgiEQLKDVTILAATNRPDRID 779
Cdd:cd19512   99 TEKISEDLRAALNAFLYRTG--EQSNKFMLVLASNQPEQFD 137
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 647-781 1.63e-08

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 54.28  E-value: 1.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 647 LKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFlaikgpelmnkYVGESERAVRETFRKAR--AVAP--S 722
Cdd:cd19510    9 IKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAGELDYDI-----------CDLNLSEVVLTDDRLNHllNTAPkqS 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767931246 723 IIFFDELDALAVER---GSSLGAGNVADRV-LAQLLTEMDGIEQLKDVTILAATNRPDRIDKV 781
Cdd:cd19510   78 IILLEDIDAAFESRehnKKNPSAYGGLSRVtFSGLLNALDGVASSEERIVFMTTNHIERLDPA 140
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 548-582 2.88e-08

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 50.23  E-value: 2.88e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767931246  548 ELLQLANSAHGYVGADLKVLCNEAGLCALRRILKK 582
Cdd:pfam17862   3 DLEELAERTEGFSGADLEALCREAALAALRRGLEA 37
44 PHA02544
clamp loader, small subunit; Provisional
 363-539 6.58e-08

clamp loader, small subunit; Provisional


Pssm-ID: 222866 [Multi-domain]  Cd Length: 316  Bit Score: 55.00  E-value: 6.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 363 KAIREIIeLPLKQPELFKSY----GIPAprgVLLYGP-PGTGKTMIARAVANEVGAYVSVINGpeiiskfygeTEAKLRQ 437
Cdd:PHA02544  18 STIDECI-LPAADKETFKSIvkkgRIPN---MLLHSPsPGTGKTTVAKALCNEVGAEVLFVNG----------SDCRIDF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 438 I------FAEATLRHP--SIIFIDELDALCPKregaqnEVEKrvvaSLLTLMDGIGSEVSegqvlVLGATNRPHALDAAL 509
Cdd:PHA02544  84 VrnrltrFASTVSLTGggKVIIIDEFDRLGLA------DAQR----HLRSFMEAYSKNCS-----FIITANNKNGIIEPL 148

                        170       180       190
                 ....*....|....*....|....*....|
gi 767931246 510 RrpGRFDkEIEIGVPNAQDRLDILQKLLRR 539
Cdd:PHA02544 149 R--SRCR-VIDFGVPTKEEQIEMMKQMIVR 175
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 390-553 1.24e-07

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 54.02  E-value: 1.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 390 VLLYGPPGTGKTMIARAVANEVGAYVSVIN-----------GPEIISKFYGETEAKLRQIFAeatlrhpSIIFIDELDAL 458
Cdd:COG0714   34 LLLEGVPGVGKTTLAKALARALGLPFIRIQftpdllpsdilGTYIYDQQTGEFEFRPGPLFA-------NVLLADEINRA 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 459 CPKregaqnevekrVVASLLTLMDgigsevsEGQVLVLGAT----NRPHAL---------------DAALRrpgRFDKEI 519
Cdd:COG0714  107 PPK-----------TQSALLEAME-------ERQVTIPGGTyklpEPFLVIatqnpieqegtyplpEAQLD---RFLLKL 165

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 767931246 520 EIGVPNAQDRLDILQKLLRR----VPHLLTEAELLQLA 553
Cdd:COG0714  166 YIGYPDAEEEREILRRHTGRhlaeVEPVLSPEELLALQ 203
ruvB TIGR00635
Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions ...
 390-463 1.01e-06

Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions are known are 5'-3' DNA helicases that, as part of a complex with RuvA homologs serve as a 5'-3' Holliday junction helicase. RuvA specifically binds Holliday junctions as a sandwich of two tetramers and maintains the configuration of the junction. It forms a complex with two hexameric rings of RuvB, the subunit that contains helicase activity. The complex drives ATP-dependent branch migration of the Holliday junction recombination intermediate. The endonuclease RuvC resolves junctions. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129721 [Multi-domain]  Cd Length: 305  Bit Score: 51.15  E-value: 1.01e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767931246  390 VLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIiskfygeteAKLRQIFAEATLRHP-SIIFIDELDALCPKRE 463
Cdd:TIGR00635  33 LLLYGPPGLGKTTLAHIIANEMGVNLKITSGPAL---------EKPGDLAAILTNLEEgDVLFIDEIHRLSPAVE 98
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 389-515 1.05e-06

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 48.44  E-value: 1.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  389 GVLLYGPPGTGKTMIARAVA----NEVGAYVSvingpeiISKFYgeTEAKLRQIFAEATL-------------RHPSIIF 451
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLAaalsNRPVFYVQ-------LTRDT--TEEDLFGRRNIDPGgaswvdgplvraaREGEIAV 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767931246  452 IDELdalcpkregaqNEVEKRVVASLLTLMDGI-------GSEVSEGQ--VLVLGATNRPHA----LDAALRRpgRF 515
Cdd:pfam07728  72 LDEI-----------NRANPDVLNSLLSLLDERrlllpdgGELVKAAPdgFRLIATMNPLDRglneLSPALRS--RF 135
TIP49 pfam06068
TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and ...
 356-442 1.09e-06

TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the pfam00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases.


Pssm-ID: 399217 [Multi-domain]  Cd Length: 347  Bit Score: 51.54  E-value: 1.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  356 GGLSSQLKAiREIIELPLkqpELFKSYGIpAPRGVLLYGPPGTGKTMIARAVANEVGAYV--SVINGPEIISKFYGETEA 433
Cdd:pfam06068  24 GGLVGQEKA-REAAGVIV---EMIKEGKI-AGRAVLIAGPPGTGKTALAIAISKELGEDTpfTSISGSEVYSLEMKKTEA 98


                  ....*....
gi 767931246  434 kLRQIFAEA 442
Cdd:pfam06068  99 -LTQAFRKA 106
TIP49 COG1224
DNA helicase TIP49, TBP-interacting protein [Transcription];
386-438 1.66e-06

DNA helicase TIP49, TBP-interacting protein [Transcription];


Pssm-ID: 440837 [Multi-domain]  Cd Length: 452  Bit Score: 51.12  E-value: 1.66e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767931246 386 APRGVLLYGPPGTGKTMIARAVANEVGA---YVSvINGPEIISKFYGETEAKLRQI 438
Cdd:COG1224   63 AGKGILIVGPPGTGKTALAVAIARELGEdtpFVA-ISGSEIYSAELKKTEFLMQAL 117
PRK04195 PRK04195
replication factor C large subunit; Provisional
 627-732 4.13e-06

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 49.92  E-value: 4.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 627 SDIGGLESIKlklEQAVEWPlkhpESFIRMgiQPPKGVLLYGPPGCSKTMIAKALANESGLNFLaikgpEL--------- 697
Cdd:PRK04195  14 SDVVGNEKAK---EQLREWI----ESWLKG--KPKKALLLYGPPGVGKTSLAHALANDYGWEVI-----ELnasdqrtad 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 767931246 698 -MNKYVGESerAVRET-FRKARavapSIIFFDELDAL 732
Cdd:PRK04195  80 vIERVAGEA--ATSGSlFGARR----KLILLDEVDGI 110
RuvB_N pfam05496
Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the ...
 390-454 4.21e-06

Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This family contains the N-terminal region of the protein.


Pssm-ID: 398900 [Multi-domain]  Cd Length: 159  Bit Score: 47.49  E-value: 4.21e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767931246  390 VLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKfyGETEAKLrqifaeATLRHPSIIFIDE 454
Cdd:pfam05496  36 VLLYGPPGLGKTTLANIIANEMGVNIRITSGPAIERP--GDLAAIL------TNLEPGDVLFIDE 92
ruvB PRK00080
Holliday junction branch migration DNA helicase RuvB;
390-454 4.38e-06

Holliday junction branch migration DNA helicase RuvB;


Pssm-ID: 234619 [Multi-domain]  Cd Length: 328  Bit Score: 49.36  E-value: 4.38e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767931246 390 VLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIiskfygETEAKLRQIFaeATLRHPSIIFIDE 454
Cdd:PRK00080  54 VLLYGPPGLGKTTLANIIANEMGVNIRITSGPAL------EKPGDLAAIL--TNLEEGDVLFIDE 110
PRK13341 PRK13341
AAA family ATPase;
391-460 5.11e-06

AAA family ATPase;


Pssm-ID: 237354 [Multi-domain]  Cd Length: 725  Bit Score: 50.05  E-value: 5.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 391 LLYGPPGTGKTMIARAVANEVGAYVSVINgpeiiSKFYGETEakLRQIFAEATLRHP-----SIIFIDEL--------DA 457
Cdd:PRK13341  56 ILYGPPGVGKTTLARIIANHTRAHFSSLN-----AVLAGVKD--LRAEVDRAKERLErhgkrTILFIDEVhrfnkaqqDA 128


                 ...
gi 767931246 458 LCP 460
Cdd:PRK13341 129 LLP 131
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 664-737 1.73e-05

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 48.13  E-value: 1.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 664 VLLYGPPGCSKTMIAKALANESGLNFLAIkgpelmnkyvgeseRAV-------RETFRKARAVA----PSIIFFDEL--- 729
Cdd:COG2256   52 MILWGPPGTGKTTLARLIANATDAEFVAL--------------SAVtsgvkdiREVIEEARERRaygrRTILFVDEIhrf 117

                         90
                 ....*....|....*
gi 767931246 730 -----DAL--AVERG 737
Cdd:COG2256  118 nkaqqDALlpHVEDG 132
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 664-737 2.43e-05

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 47.39  E-value: 2.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 664 VLLYGPPGCSKTMIAKALANESGLNFLAIKGpelmnkyVGESERAVRETFRKARAVAPS----IIFFDEL--------DA 731
Cdd:PRK13342  39 MILWGPPGTGKTTLARIIAGATDAPFEALSA-------VTSGVKDLREVIEEARQRRSAgrrtILFIDEIhrfnkaqqDA 111


                 ....*...
gi 767931246 732 L--AVERG 737
Cdd:PRK13342 112 LlpHVEDG 119
McrB COG1401
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
 386-620 2.48e-05

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 47.46  E-value: 2.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 386 APRGVLLYGPPGTGKTMIARAVANEVGAY-------VSV---------ING--PEIISKFYGETEAKLRQIFAEATL--R 445
Cdd:COG1401  220 TKKNVILAGPPGTGKTYLARRLAEALGGEdngriefVQFhpswsyedfLLGyrPSLDEGKYEPTPGIFLRFCLKAEKnpD 299

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 446 HPSIIFIDELdalcpkregaqN--EVEKrVVASLLTLMD---------------GIGSEVSEGQ-VLVLGATN---RPHA 504
Cdd:COG1401  300 KPYVLIIDEI-----------NraNVEK-YFGELLSLLEsdkrgeelsielpysGEGEEFSIPPnLYIIGTMNtddRSLA 367

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 505 L-DAALRRpgRFDKEiEIGVPNAQDRLDILQKLLRRVPHLLTEAEllqlANSAHGYVGADLKVLCNEAGLCALRRILKKQ 583
Cdd:COG1401  368 LsDKALRR--RFTFE-FLDPDLDKLSNEEVVDLLEELNEILEKRD----FQIGHRALLLLDGLLSGDLDLLLLLLLLLLE 440

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 767931246 584 PNLPDVKVAGLVKITLKDFLQAMNDIRPSAMREIAID 620
Cdd:COG1401  441 LLLLLLDKLDLLGMAEFEDRLELSEYLPLLLRASLED 477
RecA-like_Ycf2 cd19505
ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; ...
 383-521 6.90e-05

ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; however, its function remains unclear. The gene encoding YCF2 is the largest known plastid gene in angiosperms and has been used to predict phylogenetic relationships. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410913 [Multi-domain]  Cd Length: 161  Bit Score: 43.90  E-value: 6.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 383 GIPAPRGVLLYGPPGTGKTMIARAVANEvgAYVSVI---------NGPEIISK-------FYGETEAKLRQIFAEATLRH 446
Cdd:cd19505    8 GLSPSKGILLIGSIETGRSYLIKSLAAN--SYVPLIrislnkllyNKPDFGNDdwidgmlILKESLHRLNLQFELAKAMS 85

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767931246 447 PSIIF---IDELDALCPKREGAQNevEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEI 521
Cdd:cd19505   86 PCIIWipnIHELNVNRSTQNLEED--PKLLLGLLLNYLSRDFEKSSTRNILVIASTHIPQKVDPALIAPNRLDTCINI 161
PRK04195 PRK04195
replication factor C large subunit; Provisional
 383-412 7.70e-05

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 46.07  E-value: 7.70e-05
                         10        20        30
                 ....*....|....*....|....*....|
gi 767931246 383 GIPaPRGVLLYGPPGTGKTMIARAVANEVG 412
Cdd:PRK04195  36 GKP-KKALLLYGPPGVGKTSLAHALANDYG 64
RecA-like_HslU cd19498
ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease ...
 661-739 8.75e-05

ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease HslVU. In HslVU, HslU ATPase serves to unfold and translocate protein substrate, and the HslV protease degrades the unfolded proteins. This RecA-like_HslU subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410906 [Multi-domain]  Cd Length: 183  Bit Score: 43.91  E-value: 8.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 661 PKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMN-KYVG-ESERAVREtfrkaraVAPSIIFFDELDALAVERGS 738
Cdd:cd19498   46 PKNILMIGPTGVGKTEIARRLAKLAGAPFIKVEATKFTEvGYVGrDVESIIRD-------LVEGIVFIDEIDKIAKRGGS 118


                 .
gi 767931246 739 S 739
Cdd:cd19498  119 S 119
RuvB COG2255
Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, ...
 390-423 1.01e-04

Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, recombination and repair];


Pssm-ID: 441856 [Multi-domain]  Cd Length: 337  Bit Score: 45.07  E-value: 1.01e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 767931246 390 VLLYGPPGTGKTMIARAVANEVGAYVSVINGPEI 423
Cdd:COG2255   57 VLLYGPPGLGKTTLAHIIANEMGVNIRITSGPAI 90
CDC48_N smart01073
Cell division protein 48 (CDC48) N-terminal domain; This domain has a double psi-beta barrel ...
 65-133 1.14e-04

Cell division protein 48 (CDC48) N-terminal domain; This domain has a double psi-beta barrel fold and includes VCP-like ATPase and N-ethylmaleimide sensitive fusion protein N-terminal domains. Both the VAT and NSF N-terminal functional domains consist of two structural domains of which this is at the N-terminus. The VAT-N domain found in AAA ATPases is a substrate 185-residue recognition domain.


Pssm-ID: 215012 [Multi-domain]  Cd Length: 82  Bit Score: 41.44  E-value: 1.14e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246    65 NSLIHLGLNTMKSANICIGRPVLLTslNGKQEVYTAWP-MAGFPGGKVGLSEMAQKNVGVRPGDAIQVQP 133
Cdd:smart01073  14 RGIARLSPEDMDELGLFPGDYVLIT--GKRRTVAIVWPaYPEDPGGIIRIDGVQRKNAGVSIGDTVTVRK 81
RecA-like_HslU cd19498
ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease ...
 387-483 1.21e-04

ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease HslVU. In HslVU, HslU ATPase serves to unfold and translocate protein substrate, and the HslV protease degrades the unfolded proteins. This RecA-like_HslU subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410906 [Multi-domain]  Cd Length: 183  Bit Score: 43.52  E-value: 1.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 387 PRGVLLYGPPGTGKTMIARAVANEVGA-YVSVingpeIISKFygeTEAKLRQIFAEATLRH--PSIIFIDELDALCPKRE 463
Cdd:cd19498   46 PKNILMIGPTGVGKTEIARRLAKLAGApFIKV-----EATKF---TEVGYVGRDVESIIRDlvEGIVFIDEIDKIAKRGG 117

                         90       100
                 ....*....|....*....|.
gi 767931246 464 GAQNEVEKR-VVASLLTLMDG 483
Cdd:cd19498  118 SSGPDVSREgVQRDLLPIVEG 138
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 377-496 1.88e-04

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 42.88  E-value: 1.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  377 ELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEV---GAYVSVINGPEIISkFYGETEAKLRQIFAEATLRHPSIIFID 453
Cdd:pfam13191  14 DALDRVRSGRPPSVLLTGEAGTGKTTLLRELLRALerdGGYFLRGKCDENLP-YSPLLEALTREGLLRQLLDELESSLLE 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 767931246  454 ELDALCPKREGAQNEVEKRVVASLLTLMDGIGSEVSEGQ---VLVL 496
Cdd:pfam13191  93 AWRAALLEALAPVPELPGDLAERLLDLLLRLLDLLARGErplVLVL 138
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
360-416 2.00e-04

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 44.45  E-value: 2.00e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767931246 360 SQLKAIREIIElPLKQPELfksygipaPRGVLLYGPPGTGKTMIARAVANEVGAYVS 416
Cdd:COG1474   33 EEIEELASALR-PALRGER--------PSNVLIYGPTGTGKTAVAKYVLEELEEEAE 80
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 664-730 2.01e-04

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 44.00  E-value: 2.01e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767931246 664 VLLYGPPGCSKTMIAKALANESGLNFLAIKG-PELM-NKYVGES---ERAVRETFRKaRAVAPSIIFFDELD 730
Cdd:COG0714   34 LLLEGVPGVGKTTLAKALARALGLPFIRIQFtPDLLpSDILGTYiydQQTGEFEFRP-GPLFANVLLADEIN 104
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 663-781 2.08e-04

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 41.89  E-value: 2.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  663 GVLLYGPPGCSKTMIAKALANE-SGLNFLAIkgpeLMNKYVGESE--------------------RAVREtfrkaravaP 721
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLAAAlSNRPVFYV----QLTRDTTEEDlfgrrnidpggaswvdgplvRAARE---------G 67

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767931246  722 SIIFFDEldalaVERGSSlgagNVADRVLAQL----LTEMDGIEQLK----DVTILAATNRPDRIDKV 781
Cdd:pfam07728  68 EIAVLDE-----INRANP----DVLNSLLSLLderrLLLPDGGELVKaapdGFRLIATMNPLDRGLNE 126
TIP49 COG1224
DNA helicase TIP49, TBP-interacting protein [Transcription];
654-716 2.16e-04

DNA helicase TIP49, TBP-interacting protein [Transcription];


Pssm-ID: 440837 [Multi-domain]  Cd Length: 452  Bit Score: 44.58  E-value: 2.16e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767931246 654 IRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLN--FLAIKGPELMNKYVGESErAVRETFRKA 716
Cdd:COG1224   57 IKEGKMAGKGILIVGPPGTGKTALAVAIARELGEDtpFVAISGSEIYSAELKKTE-FLMQALRKA 120
RuvB_N pfam05496
Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the ...
 625-697 2.55e-04

Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This family contains the N-terminal region of the protein.


Pssm-ID: 398900 [Multi-domain]  Cd Length: 159  Bit Score: 42.10  E-value: 2.55e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767931246  625 SWSDIGGLESIKLKLEQAVEWPLKHPEsfirmgiqPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPEL 697
Cdd:pfam05496   5 TLDEYIGQEKVKENLKIFIEAAKQRGE--------ALDHVLLYGPPGLGKTTLANIIANEMGVNIRITSGPAI 69
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
384-466 4.31e-04

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 42.85  E-value: 4.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 384 IPAPRGVLLYGPPGTGKTMIARAVANE-VGAYVSV--INGPEIISKFygeTEAKLRQIFAE--ATLRHPSIIFIDELDAL 458
Cdd:COG1484   96 IERGENLILLGPPGTGKTHLAIALGHEaCRAGYRVrfTTAPDLVNEL---KEARADGRLERllKRLAKVDLLILDELGYL 172


                 ....*...
gi 767931246 459 CPKREGAQ 466
Cdd:COG1484  173 PLDAEGAE 180
PRK08116 PRK08116
hypothetical protein; Validated
 388-426 6.44e-04

hypothetical protein; Validated


Pssm-ID: 236153 [Multi-domain]  Cd Length: 268  Bit Score: 42.32  E-value: 6.44e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 767931246 388 RGVLLYGPPGTGKTMIARAVANEV---GAYVSVINGPEIISK 426
Cdd:PRK08116 115 VGLLLWGSVGTGKTYLAACIANELiekGVPVIFVNFPQLLNR 156
RecA-like_IQCA1 cd19506
ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein ...
 662-728 1.07e-03

ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein regulatory complex subunit 11, DRC11 and IQCA) is an ATPase subunit of the nexin-dynein regulatory complex (N-DRC). The 9 + 2 axoneme of most motile cilia and flagella consists of nine outer doublet microtubules arranged in a ring surrounding a central pair of two singlet microtubules. The N-DRC complex maintains alignment between outer doublet microtubules and limits microtubule sliding in motile axonemes. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410914 [Multi-domain]  Cd Length: 160  Bit Score: 40.59  E-value: 1.07e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767931246 662 KGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGES--ERAVRETFRKARAVAPSIIFFDE 728
Cdd:cd19506   27 KSLLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGKYPGKNglQMMLHLVLKVARQLQPSVIWIGD 95
RecA-like_superfamily cd01120
RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 ...
 390-485 1.49e-03

RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410865 [Multi-domain]  Cd Length: 119  Bit Score: 39.02  E-value: 1.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 390 VLLYGPPGTGKTMIARAVAN---EVGAYVSVINGPEIIskfygeteakLRQIFAEATLRHPSIIFIDELDALCPKREGAQ 466
Cdd:cd01120    1 ILITGPPGSGKTTLLLQFAEqalLSDEPVIFISFLDTI----------LEAIEDLIEEKKLDIIIIDSLSSLARASQGDR 70

                         90
                 ....*....|....*....
gi 767931246 467 NEVEKRVVASLLTLMDGIG 485
Cdd:cd01120   71 SSELLEDLAKLLRAARNTG 89
RecA-like_ClpB_Hsp104-like cd19499
Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and ...
 655-730 1.49e-03

Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and eukaryotic Heat shock protein 104 (Hsp104) are ATP-dependent molecular chaperones and essential proteins of the heat-shock response. ClpB/Hsp104 ATPases, in concert with the DnaK/Hsp70 chaperone system, disaggregate and reactivate aggregated proteins. This RecA-like_ClpB_Hsp104_like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410907 [Multi-domain]  Cd Length: 178  Bit Score: 40.24  E-value: 1.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 655 RMGIQPPK---GVLLY-GPPGCSKTMIAKALA---NESGLNFLAIKGPELMNK------------YVGESER-----AVR 710
Cdd:cd19499   31 RAGLSDPNrpiGSFLFlGPTGVGKTELAKALAellFGDEDNLIRIDMSEYMEKhsvsrligappgYVGYTEGgqlteAVR 110

                         90       100
                 ....*....|....*....|
gi 767931246 711 etfRKARavapSIIFFDELD 730
Cdd:cd19499  111 ---RKPY----SVVLLDEIE 123
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
 390-492 1.72e-03

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 39.87  E-value: 1.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  390 VLLYGPPGTGKTMIARAVANEVGAY---VSVINGPE-----IISKFYGETEAKLRQ----IFAEATLRHP-SIIFIDELD 456
Cdd:pfam07724   6 FLFLGPTGVGKTELAKALAELLFGDeraLIRIDMSEymeehSVSRLIGAPPGYVGYeeggQLTEAVRRKPySIVLIDEIE 85

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 767931246  457 ALCPkreGAQNevekrvvaSLLTLMDgiGSEVSEGQ 492
Cdd:pfam07724  86 KAHP---GVQN--------DLLQILE--GGTLTDKQ 108
ruvB PRK00080
Holliday junction branch migration DNA helicase RuvB;
664-697 1.99e-03

Holliday junction branch migration DNA helicase RuvB;


Pssm-ID: 234619 [Multi-domain]  Cd Length: 328  Bit Score: 41.27  E-value: 1.99e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 767931246 664 VLLYGPPGCSKTMIAKALANESGLNFLAIKGPEL 697
Cdd:PRK00080  54 VLLYGPPGLGKTTLANIIANEMGVNIRITSGPAL 87
RecA-like_Ycf2 cd19505
ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; ...
 654-779 2.19e-03

ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; however, its function remains unclear. The gene encoding YCF2 is the largest known plastid gene in angiosperms and has been used to predict phylogenetic relationships. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410913 [Multi-domain]  Cd Length: 161  Bit Score: 39.67  E-value: 2.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 654 IRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAI--------------KGPELMNKYVGESERAVRETFRKARAV 719
Cdd:cd19505    5 LRLGLSPSKGILLIGSIETGRSYLIKSLAANSYVPLIRIslnkllynkpdfgnDDWIDGMLILKESLHRLNLQFELAKAM 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767931246 720 APSIIFFDELDALAVERGSSLGAGNvADRVLAQLLTEM-DGIEQ--LKDVTILAATNRPDRID 779
Cdd:cd19505   85 SPCIIWIPNIHELNVNRSTQNLEED-PKLLLGLLLNYLsRDFEKssTRNILVIASTHIPQKVD 146
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
 661-730 2.65e-03

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 39.49  E-value: 2.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  661 PKGV-LLYGPPGCSKTMIAKALANESGL---NFLAIKGPELMNK------------YVGESERAVreTFRKARAVAPSII 724
Cdd:pfam07724   2 PIGSfLFLGPTGVGKTELAKALAELLFGderALIRIDMSEYMEEhsvsrligappgYVGYEEGGQ--LTEAVRRKPYSIV 79


                  ....*.
gi 767931246  725 FFDELD 730
Cdd:pfam07724  80 LIDEIE 85
DEXXQc_Helz-like cd18038
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and ...
 361-408 2.73e-03

DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and similar proteins. Helicase with zinc finger (HELZ) acts as a helicase that plays a role in RNA metabolism during development. Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. All are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350796 [Multi-domain]  Cd Length: 229  Bit Score: 40.30  E-value: 2.73e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 767931246 361 QLKAIREIIELPLKqpelfksygiPAPrgVLLYGPPGTGKTM-IARAVA 408
Cdd:cd18038    6 QKLAVRNIVTGTSR----------PPP--YIIFGPPGTGKTVtLVEAIL 42
RAD55 COG0467
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];
383-424 3.12e-03

RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];


Pssm-ID: 440235 [Multi-domain]  Cd Length: 221  Bit Score: 39.90  E-value: 3.12e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 767931246 383 GIPAPRGVLLYGPPGTGKT------MIARAVANEVGAYVSVINGPEII 424
Cdd:COG0467   16 GLPRGSSTLLSGPPGTGKTtlalqfLAEGLRRGEKGLYVSFEESPEQL 63
YifB COG0606
Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational ...
 390-405 3.28e-03

Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440371 [Multi-domain]  Cd Length: 502  Bit Score: 40.79  E-value: 3.28e-03
                         10
                 ....*....|....*.
gi 767931246 390 VLLYGPPGTGKTMIAR 405
Cdd:COG0606  214 LLMIGPPGSGKTMLAR 229
Mg_chelatase pfam01078
Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that ...
 390-406 3.36e-03

Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that catalyzes the insertion of Mg2+ into protoporphyrin IX. This is the first unique step in the synthesis of (bacterio)chlorophyll. Due to this, it is thought that Mg-chelatase has an important role in channelling inter- mediates into the (bacterio)chlorophyll branch in response to conditions suitable for photosynthetic growth. ChlI and BchD have molecular weight between 38-42 kDa.


Pssm-ID: 426032 [Multi-domain]  Cd Length: 207  Bit Score: 39.44  E-value: 3.36e-03
                          10
                  ....*....|....*..
gi 767931246  390 VLLYGPPGTGKTMIARA 406
Cdd:pfam01078  25 LLMIGPPGSGKTMLAKR 41
RecA-like_ClpB_Hsp104-like cd19499
Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and ...
 387-500 3.48e-03

Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and eukaryotic Heat shock protein 104 (Hsp104) are ATP-dependent molecular chaperones and essential proteins of the heat-shock response. ClpB/Hsp104 ATPases, in concert with the DnaK/Hsp70 chaperone system, disaggregate and reactivate aggregated proteins. This RecA-like_ClpB_Hsp104_like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410907 [Multi-domain]  Cd Length: 178  Bit Score: 39.08  E-value: 3.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 387 PRGVLLY-GPPGTGKTMIARAVANEV---GAYVSVINGPEIISKFY------------GETE-AKLrqifAEATLRHP-S 448
Cdd:cd19499   40 PIGSFLFlGPTGVGKTELAKALAELLfgdEDNLIRIDMSEYMEKHSvsrligappgyvGYTEgGQL----TEAVRRKPyS 115

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767931246 449 IIFIDELDALCPKregaqnevekrVVASLL------TLMDGIGSEVSEGQVLVLGATN 500
Cdd:cd19499  116 VVLLDEIEKAHPD-----------VQNLLLqvlddgRLTDSHGRTVDFKNTIIIMTSN 162
TIGR02928 TIGR02928
orc1/cdc6 family replication initiation protein; Members of this protein family are found ...
 387-459 4.41e-03

orc1/cdc6 family replication initiation protein; Members of this protein family are found exclusively in the archaea. This set of DNA binding proteins shows homology to the origin recognition complex subunit 1/cell division control protein 6 family in eukaryotes. Several members may be found in genome and interact with each other. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274354 [Multi-domain]  Cd Length: 365  Bit Score: 40.31  E-value: 4.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246  387 PRGVLLYGPPGTGKTMIARAVANEV-------GAYVSV--INgPEIISKFY-------------GE--------TEAKLR 436
Cdd:TIGR02928  40 PSNVFIYGKTGTGKTAVTKYVMKELeeaaedrDVRVVTvyVN-CQILDTLYqvlvelanqlrgsGEevpttglsTSEVFR 118

                          90       100
                  ....*....|....*....|....
gi 767931246  437 QIFAEATLRHPSIIFI-DELDALC 459
Cdd:TIGR02928 119 RLYKELNERGDSLIIVlDEIDYLV 142
Parvo_NS1 pfam01057
Parvovirus non-structural protein NS1; This family also contains the NS2 protein. Parvoviruses ...
 390-414 5.18e-03

Parvovirus non-structural protein NS1; This family also contains the NS2 protein. Parvoviruses encode two non-structural proteins, NS1 and NS2. The mRNA for NS2 contains the coding sequence for the first 87 amino acids of NS1, then by an alternative splicing mechanism mRNA from a different reading frame, encoding the last 78 amino acids, makes up the full length of the NS2 mRNA. NS1, is the major non-structural protein. It is essential for DNA replication. It is an 83-kDa nuclear phosphoprotein. It has DNA helicase and ATPase activity.


Pssm-ID: 426020  Cd Length: 271  Bit Score: 39.60  E-value: 5.18e-03
                          10        20
                  ....*....|....*....|....*
gi 767931246  390 VLLYGPPGTGKTMIARAVANEVGAY 414
Cdd:pfam01057 116 VWFYGPASTGKTNLAQAIAHAVPLY 140
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
658-736 5.83e-03

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 39.38  E-value: 5.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 658 IQPPKGVLLYGPPGCSKTMIAKALANE---SGLNFLAIKGPELMNK-YVGESERAVRETFRKARAVAPSIIffDELDALA 733
Cdd:COG1484   96 IERGENLILLGPPGTGKTHLAIALGHEacrAGYRVRFTTAPDLVNElKEARADGRLERLLKRLAKVDLLIL--DELGYLP 173


                 ...
gi 767931246 734 VER 736
Cdd:COG1484  174 LDA 176
BMS1 cd01882
Bms1, an essential GTPase, promotes assembly of preribosomal RNA processing complexes; Bms1 is ...
 367-421 6.35e-03

Bms1, an essential GTPase, promotes assembly of preribosomal RNA processing complexes; Bms1 is an essential, evolutionarily conserved, nucleolar protein. Its depletion interferes with processing of the 35S pre-rRNA at sites A0, A1, and A2, and the formation of 40S subunits. Bms1, the putative endonuclease Rc11, and the essential U3 small nucleolar RNA form a stable subcomplex that is believed to control an early step in the formation of the 40S subumit. The C-terminal domain of Bms1 contains a GTPase-activating protein (GAP) that functions intramolecularly. It is believed that Rc11 activates Bms1 by acting as a guanine-nucleotide exchange factor (GEF) to promote GDP/GTP exchange, and that activated (GTP-bound) Bms1 delivers Rc11 to the preribosomes.


Pssm-ID: 206669 [Multi-domain]  Cd Length: 231  Bit Score: 38.86  E-value: 6.35e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767931246 367 EIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGK-TMIARAVANEVGAYVSVINGP 421
Cdd:cd01882   19 DLEEKKLHVPVVDRTPEEPPPLVVVVVGPPGVGKsTLIRSLIKRYTKQNLSDIKGP 74
RuvB COG2255
Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, ...
 664-695 9.24e-03

Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, recombination and repair];


Pssm-ID: 441856 [Multi-domain]  Cd Length: 337  Bit Score: 38.91  E-value: 9.24e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 767931246 664 VLLYGPPGCSKTMIAKALANESGLNFLAIKGP 695
Cdd:COG2255   57 VLLYGPPGLGKTTLAHIIANEMGVNIRITSGP 88
KaiC-like cd01124
Circadian Clock Protein KaiC; KaiC is a circadian clock protein, most studied in cyanobacteria. ...
 383-485 9.74e-03

Circadian Clock Protein KaiC; KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.


Pssm-ID: 410869 [Multi-domain]  Cd Length: 222  Bit Score: 38.40  E-value: 9.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 383 GIPAPRGVLLYGPPGTGKTM-----IARAVAN-EVGAYVSV-------------------------------INGPEIIS 425
Cdd:cd01124   15 GIPKGSVTLLTGGPGTGKTLfglqfLYAGAKNgEPGLFFTFeesperllrnaksfgwdfdemedegkliivdAPPTEAGR 94

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931246 426 KFYGETEAKLRQIFAEatlRHPSIIFIDELDALcpKREGAQNEVEKRVVASLLTLMDGIG 485
Cdd:cd01124   95 FSLDELLSRILSIIKS---FKAKRVVIDSLSGL--RRAKEDQMRARRIVIALLNELRAAG 149
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH