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Conserved domains on  [gi|767931964|ref|XP_011530275|]
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AF4/FMR2 family member 1 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AF-4 pfam05110
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 15-527 0e+00

AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


:

Pssm-ID: 461550 [Multi-domain]  Cd Length: 514  Bit Score: 545.88  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964    15 YNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRLDASENR- 93
Cdd:pfam05110    1 YNEDRNLLRIREWERRNQEVQQEKDLFPENFPLFGEPYKTNKGDELSSRIQNMLGNYEEMKELITNKSNQHLVGIPKNSv 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964    94 ----LGKPKYPLIPDKGSSiPSSSFHTSVHHQSIHTPASGPLSVGnISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQD 169
Cdd:pfam05110   81 pqtpQEKPDQPFFPDKTSG-LPPSFHTSSHSQPMGPPSSSSPSVS-SSQSQKKSQARTEPAHGGHSSSGSQSSQRSQGQS 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964   170 RL--GQEGFGSSHHKKGDRRADGDHCASvtDSAPERELSPLISLPSPVPPL-SPIHSNQQTLPRTQGSSKVHGssnnsKG 246
Cdd:pfam05110  159 RSkgGQESHSSSHHKRQERREDLFSCAS--LSHSLEELSPLLSSLSSPVKPlSPSHSRQHTGSKAQNSSDHHG-----KE 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964   247 YCPAKSPKDLAVKVHDKETPQDSLVA-PAQPPSQTFPPPsLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYR 325
Cdd:pfam05110  232 YSHSKSPRDSEAGSHGPESPSTSLLAsSSQLSSQTFPPS-LPSKTSAMQQKPTAYVRPMDGQDQAPSESPELKPSPEDYH 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964   326 QQTFEK-TDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSS 404
Cdd:pfam05110  311 GQSYGKlSDLKANAKAKLSKLKIPSQPLEQSLSNDVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKESQHVTS 390

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964   405 VTQNQKQYDTSSKTHSNSQQGTsSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDS 484
Cdd:pfam05110  391 GYQNQKQYDAPSKTLPTSQQGT-SMLEDDLKLSSSEDSDDDQAPEKPPPSSAPPSAPQSQPNSVASAHSSSGESGSSSDS 469

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*
gi 767931964   485 DSSSD--SESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLT 527
Cdd:pfam05110  470 ESSSEsdSESESSSSDSEANEPPRSATPEPEPPSSNKWQLDNWLN 514
AF-4_C pfam18876
AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 957-1218 9.36e-137

AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


:

Pssm-ID: 465894  Cd Length: 262  Bit Score: 416.38  E-value: 9.36e-137
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964   957 SKPGKPQVKFDKQQ--ADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIK 1034
Cdd:pfam18876    1 SKPRRPQLKFEDRQhsADYYMQEAKKLKHKADALSDKFGKAFKYLDAALSFIECGIAMESDPQEAKSPYTMYSETVELIK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  1035 FIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSP 1114
Cdd:pfam18876   81 YVMKLKNFTDPSATTAEKIFAVLCLRCQSLLYMAMFRLKKDTAIKYSRTLNEHFKNSSKVAQAPSPCVAKSTGTPSPLSP 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  1115 MPSPASSVgsQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALN 1194
Cdd:pfam18876  161 MPSPASSV--SSQSGSSGSSGSSSSVSIPQRIHQMASSYVNITSNFLYAYEIWEQAEALARENKEFFAELDTVMGPLALN 238

                          250       260
                   ....*....|....*....|....
gi 767931964  1195 SSLVDLVHYTRQGFQQLQELTKTP 1218
Cdd:pfam18876  239 SSMTELVRYTRQGLHWLRLDAKLP 262
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 533-800 7.19e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.17  E-value: 7.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  533 AAPPEGPRSTePPRRHPESKGSSDSATSQEHSESKDP--------------PPKSSSKAPRAPPEAPHPGKRSCQKSPAQ 598
Cdd:PHA03247 2769 PAPPAAPAAG-PPRRLTRPAVASLSESRESLPSPWDPadppaavlapaaalPPAASPAGPLPPPTSAQPTAPPPPPGPPP 2847

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  599 ----------------QEPPQRQTVGTkqPKKPVKASARAGSRTSLQGEREPGLLPYGS--RDQTSKDKPKVKTKGRPRA 660
Cdd:PHA03247 2848 pslplggsvapggdvrRRPPSRSPAAK--PAAPARPPVRRLARPAVSRSTESFALPPDQpeRPPQPQAPPPPQPQPQPPP 2925

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  661 AASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDN----------VEDRTPEHFALVPLTESQGPP-HSGSGSRTS 729
Cdd:PHA03247 2926 PPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLgalvpgrvavPRFRVPQPAPSREAPASSTPPlTGHSLSRVS 3005

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767931964  730 GCRQAVVVQEDSrkDRLPLPLRDTKLLSPLRDTPPPQSLMVKIT--LDLLSRIPQPPGKGSRQRKAEDKQPPA 800
Cdd:PHA03247 3006 SWASSLALHEET--DPPPVSLKQTLWPPDDTEDSDADSLFDSDSerSDLEALDPLPPEPHDPFAHEPDPATPE 3076
 
Name Accession Description Interval E-value
AF-4 pfam05110
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 15-527 0e+00

AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


Pssm-ID: 461550 [Multi-domain]  Cd Length: 514  Bit Score: 545.88  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964    15 YNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRLDASENR- 93
Cdd:pfam05110    1 YNEDRNLLRIREWERRNQEVQQEKDLFPENFPLFGEPYKTNKGDELSSRIQNMLGNYEEMKELITNKSNQHLVGIPKNSv 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964    94 ----LGKPKYPLIPDKGSSiPSSSFHTSVHHQSIHTPASGPLSVGnISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQD 169
Cdd:pfam05110   81 pqtpQEKPDQPFFPDKTSG-LPPSFHTSSHSQPMGPPSSSSPSVS-SSQSQKKSQARTEPAHGGHSSSGSQSSQRSQGQS 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964   170 RL--GQEGFGSSHHKKGDRRADGDHCASvtDSAPERELSPLISLPSPVPPL-SPIHSNQQTLPRTQGSSKVHGssnnsKG 246
Cdd:pfam05110  159 RSkgGQESHSSSHHKRQERREDLFSCAS--LSHSLEELSPLLSSLSSPVKPlSPSHSRQHTGSKAQNSSDHHG-----KE 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964   247 YCPAKSPKDLAVKVHDKETPQDSLVA-PAQPPSQTFPPPsLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYR 325
Cdd:pfam05110  232 YSHSKSPRDSEAGSHGPESPSTSLLAsSSQLSSQTFPPS-LPSKTSAMQQKPTAYVRPMDGQDQAPSESPELKPSPEDYH 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964   326 QQTFEK-TDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSS 404
Cdd:pfam05110  311 GQSYGKlSDLKANAKAKLSKLKIPSQPLEQSLSNDVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKESQHVTS 390

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964   405 VTQNQKQYDTSSKTHSNSQQGTsSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDS 484
Cdd:pfam05110  391 GYQNQKQYDAPSKTLPTSQQGT-SMLEDDLKLSSSEDSDDDQAPEKPPPSSAPPSAPQSQPNSVASAHSSSGESGSSSDS 469

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*
gi 767931964   485 DSSSD--SESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLT 527
Cdd:pfam05110  470 ESSSEsdSESESSSSDSEANEPPRSATPEPEPPSSNKWQLDNWLN 514
AF-4_C pfam18876
AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 957-1218 9.36e-137

AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


Pssm-ID: 465894  Cd Length: 262  Bit Score: 416.38  E-value: 9.36e-137
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964   957 SKPGKPQVKFDKQQ--ADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIK 1034
Cdd:pfam18876    1 SKPRRPQLKFEDRQhsADYYMQEAKKLKHKADALSDKFGKAFKYLDAALSFIECGIAMESDPQEAKSPYTMYSETVELIK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  1035 FIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSP 1114
Cdd:pfam18876   81 YVMKLKNFTDPSATTAEKIFAVLCLRCQSLLYMAMFRLKKDTAIKYSRTLNEHFKNSSKVAQAPSPCVAKSTGTPSPLSP 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  1115 MPSPASSVgsQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALN 1194
Cdd:pfam18876  161 MPSPASSV--SSQSGSSGSSGSSSSVSIPQRIHQMASSYVNITSNFLYAYEIWEQAEALARENKEFFAELDTVMGPLALN 238

                          250       260
                   ....*....|....*....|....
gi 767931964  1195 SSLVDLVHYTRQGFQQLQELTKTP 1218
Cdd:pfam18876  239 SSMTELVRYTRQGLHWLRLDAKLP 262
PHA03247 PHA03247
large tegument protein UL36; Provisional
 533-800 7.19e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.17  E-value: 7.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  533 AAPPEGPRSTePPRRHPESKGSSDSATSQEHSESKDP--------------PPKSSSKAPRAPPEAPHPGKRSCQKSPAQ 598
Cdd:PHA03247 2769 PAPPAAPAAG-PPRRLTRPAVASLSESRESLPSPWDPadppaavlapaaalPPAASPAGPLPPPTSAQPTAPPPPPGPPP 2847

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  599 ----------------QEPPQRQTVGTkqPKKPVKASARAGSRTSLQGEREPGLLPYGS--RDQTSKDKPKVKTKGRPRA 660
Cdd:PHA03247 2848 pslplggsvapggdvrRRPPSRSPAAK--PAAPARPPVRRLARPAVSRSTESFALPPDQpeRPPQPQAPPPPQPQPQPPP 2925

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  661 AASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDN----------VEDRTPEHFALVPLTESQGPP-HSGSGSRTS 729
Cdd:PHA03247 2926 PPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLgalvpgrvavPRFRVPQPAPSREAPASSTPPlTGHSLSRVS 3005

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767931964  730 GCRQAVVVQEDSrkDRLPLPLRDTKLLSPLRDTPPPQSLMVKIT--LDLLSRIPQPPGKGSRQRKAEDKQPPA 800
Cdd:PHA03247 3006 SWASSLALHEET--DPPPVSLKQTLWPPDDTEDSDADSLFDSDSerSDLEALDPLPPEPHDPFAHEPDPATPE 3076
AF4_int pfam18875
AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.
 768-782 1.27e-03

AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.


Pssm-ID: 436798  Cd Length: 15  Bit Score: 37.02  E-value: 1.27e-03
                           10
                   ....*....|....*
gi 767931964   768 LMVKITLDLLSRIPQ 782
Cdd:pfam18875    1 LVVKIDLSLLSRVPQ 15
 
Name Accession Description Interval E-value
AF-4 pfam05110
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 15-527 0e+00

AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


Pssm-ID: 461550 [Multi-domain]  Cd Length: 514  Bit Score: 545.88  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964    15 YNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRLDASENR- 93
Cdd:pfam05110    1 YNEDRNLLRIREWERRNQEVQQEKDLFPENFPLFGEPYKTNKGDELSSRIQNMLGNYEEMKELITNKSNQHLVGIPKNSv 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964    94 ----LGKPKYPLIPDKGSSiPSSSFHTSVHHQSIHTPASGPLSVGnISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQD 169
Cdd:pfam05110   81 pqtpQEKPDQPFFPDKTSG-LPPSFHTSSHSQPMGPPSSSSPSVS-SSQSQKKSQARTEPAHGGHSSSGSQSSQRSQGQS 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964   170 RL--GQEGFGSSHHKKGDRRADGDHCASvtDSAPERELSPLISLPSPVPPL-SPIHSNQQTLPRTQGSSKVHGssnnsKG 246
Cdd:pfam05110  159 RSkgGQESHSSSHHKRQERREDLFSCAS--LSHSLEELSPLLSSLSSPVKPlSPSHSRQHTGSKAQNSSDHHG-----KE 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964   247 YCPAKSPKDLAVKVHDKETPQDSLVA-PAQPPSQTFPPPsLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYR 325
Cdd:pfam05110  232 YSHSKSPRDSEAGSHGPESPSTSLLAsSSQLSSQTFPPS-LPSKTSAMQQKPTAYVRPMDGQDQAPSESPELKPSPEDYH 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964   326 QQTFEK-TDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSS 404
Cdd:pfam05110  311 GQSYGKlSDLKANAKAKLSKLKIPSQPLEQSLSNDVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKESQHVTS 390

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964   405 VTQNQKQYDTSSKTHSNSQQGTsSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDS 484
Cdd:pfam05110  391 GYQNQKQYDAPSKTLPTSQQGT-SMLEDDLKLSSSEDSDDDQAPEKPPPSSAPPSAPQSQPNSVASAHSSSGESGSSSDS 469

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*
gi 767931964   485 DSSSD--SESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLT 527
Cdd:pfam05110  470 ESSSEsdSESESSSSDSEANEPPRSATPEPEPPSSNKWQLDNWLN 514
AF-4_C pfam18876
AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 957-1218 9.36e-137

AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


Pssm-ID: 465894  Cd Length: 262  Bit Score: 416.38  E-value: 9.36e-137
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964   957 SKPGKPQVKFDKQQ--ADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIK 1034
Cdd:pfam18876    1 SKPRRPQLKFEDRQhsADYYMQEAKKLKHKADALSDKFGKAFKYLDAALSFIECGIAMESDPQEAKSPYTMYSETVELIK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  1035 FIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSP 1114
Cdd:pfam18876   81 YVMKLKNFTDPSATTAEKIFAVLCLRCQSLLYMAMFRLKKDTAIKYSRTLNEHFKNSSKVAQAPSPCVAKSTGTPSPLSP 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  1115 MPSPASSVgsQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALN 1194
Cdd:pfam18876  161 MPSPASSV--SSQSGSSGSSGSSSSVSIPQRIHQMASSYVNITSNFLYAYEIWEQAEALARENKEFFAELDTVMGPLALN 238

                          250       260
                   ....*....|....*....|....
gi 767931964  1195 SSLVDLVHYTRQGFQQLQELTKTP 1218
Cdd:pfam18876  239 SSMTELVRYTRQGLHWLRLDAKLP 262
PHA03247 PHA03247
large tegument protein UL36; Provisional
 533-800 7.19e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.17  E-value: 7.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  533 AAPPEGPRSTePPRRHPESKGSSDSATSQEHSESKDP--------------PPKSSSKAPRAPPEAPHPGKRSCQKSPAQ 598
Cdd:PHA03247 2769 PAPPAAPAAG-PPRRLTRPAVASLSESRESLPSPWDPadppaavlapaaalPPAASPAGPLPPPTSAQPTAPPPPPGPPP 2847

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  599 ----------------QEPPQRQTVGTkqPKKPVKASARAGSRTSLQGEREPGLLPYGS--RDQTSKDKPKVKTKGRPRA 660
Cdd:PHA03247 2848 pslplggsvapggdvrRRPPSRSPAAK--PAAPARPPVRRLARPAVSRSTESFALPPDQpeRPPQPQAPPPPQPQPQPPP 2925

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  661 AASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDN----------VEDRTPEHFALVPLTESQGPP-HSGSGSRTS 729
Cdd:PHA03247 2926 PPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLgalvpgrvavPRFRVPQPAPSREAPASSTPPlTGHSLSRVS 3005

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767931964  730 GCRQAVVVQEDSrkDRLPLPLRDTKLLSPLRDTPPPQSLMVKIT--LDLLSRIPQPPGKGSRQRKAEDKQPPA 800
Cdd:PHA03247 3006 SWASSLALHEET--DPPPVSLKQTLWPPDDTEDSDADSLFDSDSerSDLEALDPLPPEPHDPFAHEPDPATPE 3076
PHA03247 PHA03247
large tegument protein UL36; Provisional
 530-767 4.83e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 4.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  530 SQPAAPPEGPRSTEPPRRhPESkgSSDSATSQEHSESKDPPPKSSSKAPrAPPEAPHPGKRSCQKSPAQQEPPQRQTVGT 609
Cdd:PHA03247 2571 PRPAPRPSEPAVTSRARR-PDA--PPQSARPRAPVDDRGDPRGPAPPSP-LPPDTHAPDPPPPSPSPAANEPDPHPPPTV 2646

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  610 KQPKKPVKASarAGSRTSL-QGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSK 688
Cdd:PHA03247 2647 PPPERPRDDP--APGRVSRpRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPG 2724

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767931964  689 ALSGPEpakdnvedrtpehfALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQS 767
Cdd:PHA03247 2725 PAAARQ--------------ASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVA 2789
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
534-698 3.21e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 45.23  E-value: 3.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  534 APPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRScQKSPAQQEPPQRQTVGTKQPK 613
Cdd:PRK07003  366 GAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRA-EAPPAAPAPPATADRGDDAAD 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  614 KPVKASARAGSRTSL-----------QGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSS 682
Cdd:PRK07003  445 GDAPVPAKANARASAdsrcderdaqpPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAA 524

                         170
                  ....*....|....*.
gi 767931964  683 LPAPSKALSGPEPAKD 698
Cdd:PRK07003  525 AAPPAPEARPPTPAAA 540
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
529-709 8.68e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.71  E-value: 8.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  529 VSQPAAPPEGPRSTEPPRRHPE-----SKGSSDSATSQEHSESKDPPPKSSSKAPR-----------APPEAPHPGKRSC 592
Cdd:PRK12323  382 VAQPAPAAAAPAAAAPAPAAPPaapaaAPAAAAAARAVAAAPARRSPAPEALAAARqasargpggapAPAPAPAAAPAAA 461

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  593 QKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPP 672
Cdd:PRK12323  462 ARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETL 541

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 767931964  673 SSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFA 709
Cdd:PRK12323  542 APAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFD 578
AF4_int pfam18875
AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.
 768-782 1.27e-03

AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.


Pssm-ID: 436798  Cd Length: 15  Bit Score: 37.02  E-value: 1.27e-03
                           10
                   ....*....|....*
gi 767931964   768 LMVKITLDLLSRIPQ 782
Cdd:pfam18875    1 LVVKIDLSLLSRVPQ 15
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 530-710 1.71e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 1.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  530 SQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGT 609
Cdd:PRK07764  634 AAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQ 713

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  610 KQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVktKGRPRAAASNEPKPAVPPSSEKKkhksslPAPSKA 689
Cdd:PRK07764  714 ADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPA--QPPPPPAPAPAAAPAAAPPPSPP------SEEEEM 785

                         170       180
                  ....*....|....*....|.
gi 767931964  690 LSGPEPAKDNVEDRTPEHFAL 710
Cdd:PRK07764  786 AEDDAPSMDDEDRRDAEEVAM 806
dnaA PRK14086
chromosomal replication initiator protein DnaA;
531-696 2.59e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 42.12  E-value: 2.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  531 QPAAPPEGPRSTEPPRRHPESKGSSDSATSQEhSESKDPPPKSSSKAPRAPPEAP---HPGKRSCQKSPAQQEPPQRQTV 607
Cdd:PRK14086   94 EPAPPPPHARRTSEPELPRPGRRPYEGYGGPR-ADDRPPGLPRQDQLPTARPAYPayqQRPEPGAWPRAADDYGWQQQRL 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  608 GTKQPKKPvkASARAGSRTSLQGEREPGL----LPYGSRDQT----SKDKPKVKTKGRPRAAASNE------PKPAVPPS 673
Cdd:PRK14086  173 GFPPRAPY--ASPASYAPEQERDREPYDAgrpeYDQRRRDYDhprpDWDRPRRDRTDRPEPPPGAGhvhrggPGPPERDD 250

                         170       180
                  ....*....|....*....|...
gi 767931964  674 SEKKKHKSSLPAPSKALSGPEPA 696
Cdd:PRK14086  251 APVVPIRPSAPGPLAAQPAPAPG 273
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 532-623 3.05e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 41.62  E-value: 3.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  532 PAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSeskdPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQ 611
Cdd:PRK14951  389 PAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAA----PPAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQAAPETVAIPV 464

                          90
                  ....*....|..
gi 767931964  612 PKKPVKASARAG 623
Cdd:PRK14951  465 RVAPEPAVASAA 476
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 520-765 4.14e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.70  E-value: 4.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  520 WQLDNWLTKVSQPAA-------------PPEGPRSTEPPRRHPESKGSSD---------------SATSQEHSESKDP-- 569
Cdd:PHA03307  170 RQAALPLSSPEETARapssppaepppstPPAAASPRPPRRSSPISASASSpapapgrsaaddagaSSSDSSSSESSGCgw 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  570 --------PPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGS 641
Cdd:PHA03307  250 gpenecplPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSST 329

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  642 RDQTSKDKPKVKTKGRP--RAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDnvedrtpehfALVPLTESQGP 719
Cdd:PHA03307  330 SSSSESSRGAAVSPGPSpsRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRR----------RARAAVAGRAR 399

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 767931964  720 PHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRD-TKLLSPLRDTPPP 765
Cdd:PHA03307  400 RRDATGRFPAGRPRPSPLDAGAASGAFYARYPLlTPSGEPWPGSPPP 446
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
530-720 5.09e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.01  E-value: 5.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  530 SQPAAPPEGPRSTEPPRRHPESkgssdsatsqehseSKDPPPKSSSKAPRAPPEAPHPGkrscqkspaqqePPQRQTVGT 609
Cdd:PRK12323  372 AGPATAAAAPVAQPAPAAAAPA--------------AAAPAPAAPPAAPAAAPAAAAAA------------RAVAAAPAR 425

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  610 KQPKKPVKASARAGSRTSLQGEREPGLLPygsrdqtskdkPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPskA 689
Cdd:PRK12323  426 RSPAPEALAAARQASARGPGGAPAPAPAP-----------AAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAP--A 492

                         170       180       190
                  ....*....|....*....|....*....|.
gi 767931964  690 LSGPEPAKDnvedrTPEHFALVPLTESQGPP 720
Cdd:PRK12323  493 DDDPPPWEE-----LPPEFASPAPAQPDAAP 518
PHA03325 PHA03325
nuclear-egress-membrane-like protein; Provisional
 532-672 6.72e-03

nuclear-egress-membrane-like protein; Provisional


Pssm-ID: 223044  Cd Length: 418  Bit Score: 40.25  E-value: 6.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  532 PAAPPEGPRSTEPPRRHPESKGSSDSATSQE-------HSESKDPPPKSSSKAPrAPPEAPHPGKRSCQKSP------AQ 598
Cdd:PHA03325  260 SAFMLNSSLPTSAPKRRSRRAGAMRAAAGETadladddGSEHSDPEPLPASLPP-PPVRRPRVKHPEAGKEEpdgarnAE 338

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767931964  599 QEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPP 672
Cdd:PHA03325  339 AKEPAQPATSTSSKGSSSAQNKDSGSTGPGSSLAAASSFLEDDDFGSPPLDLTTSLRHMPSPSVTSAPEPPSIP 412
PHA03247 PHA03247
large tegument protein UL36; Provisional
 532-906 7.15e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 7.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  532 PAAPPEGPRSTEPPRRhPESKGSSDSATSQEHSES--------------KDPPPKSSSKAPrAPPEAPHPGKRSCQKSPA 597
Cdd:PHA03247 2557 PAAPPAAPDRSVPPPR-PAPRPSEPAVTSRARRPDappqsarprapvddRGDPRGPAPPSP-LPPDTHAPDPPPPSPSPA 2634

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  598 QQEPPQRQTVGTKQPKKPVKASAraGSRTSL-QGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEK 676
Cdd:PHA03247 2635 ANEPDPHPPPTVPPPERPRDDPA--PGRVSRpRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAP 2712

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  677 KKHKSSLPAPSKALSGPEpakdnvedrtpehfALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDtkll 756
Cdd:PHA03247 2713 HALVSATPLPPGPAAARQ--------------ASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAA---- 2774

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  757 splRDTPPPQslmvkitldllsRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGeaerdcdnkkirl 836
Cdd:PHA03247 2775 ---PAAGPPR------------RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAG------------- 2826

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767931964  837 ekeiKSQSSSSSSSHKESSKTKPSRPS-----SQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKS 906
Cdd:PHA03247 2827 ----PLPPPTSAQPTAPPPPPGPPPPSlplggSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTES 2897
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 539-712 7.23e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.74  E-value: 7.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  539 PRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKA 618
Cdd:PRK07764  376 ARLERLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPS 455

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  619 SARAGSrtslqgerepgllpyGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSekkkhksslPAPSKALSGPEPAkD 698
Cdd:PRK07764  456 PPPAAA---------------PSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAA---------PAAPAAPAGADDA-A 510

                         170
                  ....*....|....
gi 767931964  699 NVEDRTPEHFALVP 712
Cdd:PRK07764  511 TLRERWPEILAAVP 524
DUF4045 pfam13254
Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. ...
 533-672 7.62e-03

Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. This domain family is found in bacteria and eukaryotes, and is typically between 384 and 430 amino acids in length.


Pssm-ID: 433066 [Multi-domain]  Cd Length: 415  Bit Score: 40.15  E-value: 7.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964   533 AAPPEGPRSTEPPRRHpeSKGSSDSATSQEHSESKDPPPKSSSkaPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQP 612
Cdd:pfam13254  202 EVTPVGLMRSPAPGGH--SKSPSVSGISADSSPTKEEPSEEAD--TLSTDKEQSPAPTSASEPPPKTKELPKDSEEPAAP 277

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767931964   613 KKPVKASARA------GSRTSLQGEREPGLLPYGSRdqTSKDKPKVKTkgrPRAAASNEPKPAVPP 672
Cdd:pfam13254  278 SKSAEASTEKkepdteSSPETSSEKSAPSLLSPVSK--ASIDKPLSSP---DRDPLSPKPKPQSPP 338
PHA03247 PHA03247
large tegument protein UL36; Provisional
 575-784 8.18e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 8.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  575 SKAPRAPPEAPHPGKrSCQKSPAQQEPPQRQTvGTKQPKKPVKASARAGSRTSLQGERE----------PGLLPYGSRDQ 644
Cdd:PHA03247 2486 ARFPFAAGAAPDPGG-GGPPDPDAPPAPSRLA-PAILPDEPVGEPVHPRMLTWIRGLEElasddagdppPPLPPAAPPAA 2563

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  645 TSKDKPKVKTKGRPR--AAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHS 722
Cdd:PHA03247 2564 PDRSVPPPRPAPRPSepAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPP 2643

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767931964  723 GSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPP 784
Cdd:PHA03247 2644 PTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPP 2705
PHA03247 PHA03247
large tegument protein UL36; Provisional
 528-763 8.39e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 8.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  528 KVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPE----------APHPGKRSCQKSPA 597
Cdd:PHA03247  274 GATGPPPPPEAAAPNGAAAPPDGVWGAALAGAPLALPAPPDPPPPAPAGDAEEEDDedgamevvspLPRPRQHYPLGFPK 353

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  598 QQEPP-------QRQTVGTKQPKkpvKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKP---KVKTKGRPRAAASNEPK 667
Cdd:PHA03247  354 RRRPTwtppsslEDLSAGRHHPK---RASLPTRKRRSARHAATPFARGPGGDDQTRPAAPvpaSVPTPAPTPVPASAPPP 430

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931964  668 PAVPPSSEKKKHKSSlPAPSKALSGPEPAKDNVEDRTPE--HFALVPLTESQGP--------------PHSGSGSRTSGC 731
Cdd:PHA03247  431 PATPLPSAEPGSDDG-PAPPPERQPPAPATEPAPDDPDDatRKALDALRERRPPeppgadlaellgrhPDTAGTVVRLAA 509

                         250       260       270
                  ....*....|....*....|....*....|..
gi 767931964  732 RQAVVVQEDSRKDRLPLplrdTKLLSPLRDTP 763
Cdd:PHA03247  510 REAAIAREVAECSRLTI----NALRSPFPASP 537
PHA03291 PHA03291
envelope glycoprotein I; Provisional
 526-601 9.61e-03

envelope glycoprotein I; Provisional


Pssm-ID: 223033 [Multi-domain]  Cd Length: 401  Bit Score: 39.94  E-value: 9.61e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767931964  526 LTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAP--PEAPHPGKRSCQKSPAQQEP 601
Cdd:PHA03291  199 PADVFVPATPRPTPRTTASPETTPTPSTTTSPPSTTIPAPSTTIAAPQAGTTPEAEgtPAPPTPGGGEAPPANATPAP 276
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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