cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. CCNG2 contains one cyclin box. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933017  55 LRNAKVEDLRSLANFFGSCTETFVLAVNILDRFLALMKVKPKHLSCIGVCSFLLAARIVEEDCNIPSTHDVIRISQCKCT 134
Cdd:cd20584    1 LRDAKVEDLWSLTNFFGFSTETFVLAVNILDRFLALMKVKPKHLSCIGICCFHLAARVVEEECNIPSSHDLIRISQCKCT 80

                         90
                 ....*....|....*.
gi 767933017 135 ASDIKRMEKIISEKLH 150
Cdd:cd20584   81 VSDLKRMEKIISEKLH 96

cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. CCNG2 contains one cyclin box. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933017  55 LRNAKVEDLRSLANFFGSCTETFVLAVNILDRFLALMKVKPKHLSCIGVCSFLLAARIVEEDCNIPSTHDVIRISQCKCT 134
Cdd:cd20584    1 LRDAKVEDLWSLTNFFGFSTETFVLAVNILDRFLALMKVKPKHLSCIGICCFHLAARVVEEECNIPSSHDLIRISQCKCT 80

                         90
                 ....*....|....*.
gi 767933017 135 ASDIKRMEKIISEKLH 150
Cdd:cd20584   81 VSDLKRMEKIISEKLH 96

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933017    63 LRSLANFFGSCTETFVLAVNILDRFLALMKVKPKHLSCIGVCSFLLAARIVEEDcniPSTHDVIRISQcKCTASDIKRME 142
Cdd:smart00385   3 LRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETP---PWTKELVHYTG-YFTEEEILRME 78

                   ...
gi 767933017   143 KII 145
Cdd:smart00385  79 RLL 81

cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. CCNG2 contains one cyclin box. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933017  55 LRNAKVEDLRSLANFFGSCTETFVLAVNILDRFLALMKVKPKHLSCIGVCSFLLAARIVEEDCNIPSTHDVIRISQCKCT 134
Cdd:cd20584    1 LRDAKVEDLWSLTNFFGFSTETFVLAVNILDRFLALMKVKPKHLSCIGICCFHLAARVVEEECNIPSSHDLIRISQCKCT 80

                         90
                 ....*....|....*.
gi 767933017 135 ASDIKRMEKIISEKLH 150
Cdd:cd20584   81 VSDLKRMEKIISEKLH 96

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933017  55 LRNAKVEDLRSLANFFGSCTETFVLAVNILDRFLALMKVKPKHLSCIGVCSFLLAARIVEEDCNIPSTHDVIRISQCKCT 134
Cdd:cd20583    1 LRDFEVKDLLSLTQFFGFSTETFSLAVNLLDRFLAKMKVQPKHLGCVGLSCFYLAVKAIEEERNVPLATDLIRISQYRFT 80

                         90
                 ....*....|....*...
gi 767933017 135 ASDIKRMEKIISEKLHYE 152
Cdd:cd20583   81 VSDMMRMEKIILEKLCWK 98

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933017   24 YLEQEERFQPREkglSLIEATPENDntlcPGLRNAKVEDLRSLANFFGSCTETFVLAVNILDRFLALMKVKPKHLSCIGV 103
Cdd:pfam00134   6 LRELELKYLPKP---DYMDQQPDIN----PKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGV 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 767933017  104 CSFLLAARIveEDCNIPSTHDVIRISQCKCTASDIKRMEKIISEKLHYEL 153
Cdd:pfam00134  79 TCLFIAAKY--EEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDL 126

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933017    63 LRSLANFFGSCTETFVLAVNILDRFLALMKVKPKHLSCIGVCSFLLAARIVEEDcniPSTHDVIRISQcKCTASDIKRME 142
Cdd:smart00385   3 LRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETP---PWTKELVHYTG-YFTEEEILRME 78

                   ...
gi 767933017   143 KII 145
Cdd:smart00385  79 RLL 81

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933017  70 FGSCTETFVLAVNILDRFLALMKVKPKHLSCIGVCSFLLAARIVEedCNIPSTHDVIRISQCKCTASDIKRMEKIISEKL 149
Cdd:cd20536   16 FNLSQETLFLAVNILDRFLATTPVARDCFQLLGVTSLLIACKQEE--IYPPEVKDLLALCCGAYTREQICNLECIILTKL 93

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767933017  75 ETFVLAVNILDRFLALMKVKPKH-LSCIGVCSFLLAARIveEDCNIPSTHDVIRISQCKCTASDIKRMEKIISEKL 149
Cdd:cd20519   56 ETFYLAVDFVDRYLSTQTNVPKTqLQLIGITCLFIAAKL--EEIYPPKLSEFAYVTDGACTEDEILTMELIILKAL 129

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933017  63 LRSLANFFGSCTETFVLAVNILDRFLALMKVKPKHLSCIGVCSFLLAARIVEEDcniPSTHDVIRISQckCTASDIKRME 142
Cdd:cd00043    6 IRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELP---RTLKEIAKVSG--VSEKELRKAE 80

                 ..
gi 767933017 143 KI 144
Cdd:cd00043   81 KE 82

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933017  54 GLRNAKVEDLRSLANFFGSCTETFVLAVNILDRFLALMKVKPKHLSCIGVCSFLLAARIVEEDCNIPSTHDVIRISQC-K 132
Cdd:cd20528    5 HLRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQLHLVALTCLLLAAKFEELDDNIPKISDLNRYLCNsV 84

                         90
                 ....*....|
gi 767933017 133 CTASDIKRME 142
Cdd:cd20528   85 YSKQEYLQME 94

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933017  53 PGLRNAKVEDLRSLANFFGSCTETFVLAVNILDRFLALMKVKPKHLSCIGVCSFLLAARIveEDCNIPSTHDVIRISQCK 132
Cdd:cd20560   66 TGMRTILVDWLVEVGEEYKLQTETLYLAVNYLDRFLSCMSVLRGKLQLVGTAAILLASKY--EEIYPPEVDEFVYITDDT 143

                         90       100
                 ....*....|....*....|
gi 767933017 133 CTASDIKRMEKIISEKLHYE 152
Cdd:cd20560  144 YTKKQLLRMEHLLLKVLAFD 163

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767933017  75 ETFVLAVNILDRFLALMKVKPKHLSCIGVCSFLLAARIveEDCNIPSTHDVIRISQCKCTASDIKRMEKIISEKLHYE 152
Cdd:cd20561   56 ETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKF--EEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFD 131

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767933017  75 ETFVLAVNILDRFLALMKVKPKHLSCIGVCSFLLAARIvEEDCNiPSTHDVIRISQCKCTASDIKRMEKIISEKLHY 151
Cdd:cd20508   67 ETLYLAVKLVDLYLSKKVVKKEKLQLLGATAILIASKF-DERCP-PCVDDFLYICDDAYTREELLKMEREILKTLDF 141

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933017  74 TETFVLAVNILDRFLALMKVKPKHLSCIGVCSFLLAARIVEedCNIPSTHDVIRISQCKCTASDIKRMEKIISEKLHYEL 153
Cdd:cd20542   19 TQTLHLAVALLDRYLSRQKISLSLLQLLGITCLFIACKFEE--RFPPEVATLCYLTDDSYSKKQVLRMERRVLRRLRFDL 96

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 767933017  74 TETFVLAVNILDRFLALMKVKPKHLSCIGVCSFLLAARIVEED 116
Cdd:cd20521   22 SLTLHVAVSCVDRYLMVRKVPRSKLQLLGIACMVIATRFLGKD 64

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767933017  75 ETFVLAVNILDRFLALMKVKPKHLSCIGVCSFLLAARIVEedcNIPSTHDVIrisqCKCTASDIKRME 142
Cdd:cd20574   75 EVFPLAMNYLDRFLAVVPTRKCHLQLLGAVCMFLASKLKE---TIPLTAEKL----CIYTDNSIKPQE 135

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933017  16 QLLG---LLNVYLEQEERFQPREKGLSLIEatpendNTLCPGLRNAKVEDLRSLANFFGSCTETFVLAVNILDRFLALMK 92
Cdd:cd20575   19 RLLGdqrVLQNLLRLEERYVPRVSYFQCVQ------REIKPYMRKMLAYWMLEVCEEQKCEEEVFPLAMNYVDRYLSCVP 92

                         90       100
                 ....*....|....*....|..
gi 767933017  93 VKPKHLSCIGVCSFLLAARIVE 114
Cdd:cd20575   93 TRKAQLQLLGAVCMLLASKLRE 114

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933017  76 TFVLAVNILDRFLALMKVKPKHLSCIGVCSFLLAARIVEEDCNIPSTHDVIRISQCKCTASDIKRMEKII 145
Cdd:cd20559   19 TFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASKFWESKARVPLLSELSKMCCNSYGEELFIQMEMHI 88