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Conserved domains on  [gi|767914564|ref|XP_011531163|]
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latent-transforming growth factor beta-binding protein 1 isoform X20 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 688-729 2.08e-13

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 65.76  E-value: 2.08e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 767914564   688 QCMHPLSVHLTKQLCCC-SVGKAWGPHCEKCPLPGTAAFKEIC 729
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1270-1312 1.25e-10

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 58.06  E-value: 1.25e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 767914564  1270 CDNVLAPNVTKQECCCTS-GVGWGDNCEifPCPVLGTAEFTEMC 1312
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSvGRAWGSPCE--LCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1446-1488 7.85e-10

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 55.75  E-value: 7.85e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 767914564  1446 VCSRPLVGkQTTYTECCCLY-GEAWGMQCALCPLKDSDDYAQLC 1488
Cdd:pfam00683    2 RCSNPLPG-NVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
1203-1244 8.04e-09

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 52.63  E-value: 8.04e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 767914564   1203 DINECEHPGLCGPQGECLNTEGSFHCVCQQGFSisaDGRTCE 1244
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1121-1161 2.31e-07

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.40  E-value: 2.31e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 767914564   1121 DIDECQHRHLCAHG-QCRNTEGSFQCVCDQGYRAsglGDHCE 1161
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1080-1111 8.51e-07

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 8.51e-07
                            10        20        30
                    ....*....|....*....|....*....|...
gi 767914564   1080 DIDECQQGNLCVNG-QCKNTEGSFRCTCGQGYQ 1111
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1039-1078 3.39e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 3.39e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 767914564   1039 DVDECLEPNVCANG-DCSNLEGSYMCSCHKGYTrtpDHKHC 1078
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
916-957 9.50e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 9.50e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767914564    916 DIDECTQVqHLCSQG-RCENTEGSFLCICPAGFmasEEGTNCI 957
Cdd:smart00179    1 DIDECASG-NPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
626-656 9.88e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 9.88e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 767914564    626 DINECQLQGVCPNG-ECLNTMGSYRCTCKIGF 656
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1162-1192 1.78e-05

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.99  E-value: 1.78e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767914564  1162 DINECLEDKSVCQR-GDCINTAGSYDCTCPDG 1192
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1573-1607 7.93e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 7.93e-05
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 767914564   1573 DVNECDELNNrmslCKN-AKCINTDGSYKCLCLPGY 1607
Cdd:smart00179    1 DIDECASGNP----CQNgGTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
958-998 1.43e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.43e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 767914564    958 DVDECLRPDVCGEG-HCVNTVGAFRCEyCDSGYrmTQRGRCE 998
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCE-CPPGY--TDGRNCE 39
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 567-602 4.00e-04

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 39.57  E-value: 4.00e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767914564   567 QCGKALPG-LSKQEDCCGTVGTSWGfNKCQKCPKKPS 602
Cdd:pfam00683    2 RCSNPLPGnVTKSECCCTSVGRAWG-SPCELCPPPGT 37
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 742-869 4.86e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 4.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914564  742 RRRPIHHHVGKGPVfvkPKNTQPVAKsthPPPLPAKEEPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPG 821
Cdd:PHA03247 2878 PARPPVRRLARPAV---SRSTESFAL---PPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAG 2951

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767914564  822 QPQLSPGISTIHLHPQFPG---IVIEKTSPPVPVEVAPEASTSSASQVIAP 869
Cdd:PHA03247 2952 AGEPSGAVPQPWLGALVPGrvaVPRFRVPQPAPSREAPASSTPPLTGHSLS 3002
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 999-1032 1.52e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.52e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767914564  999 DIDECLNPSTC-PDEQCVNSPGSYQCVpCTEGFRG 1032
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
1378-1404 8.58e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 8.58e-03
                            10        20
                    ....*....|....*....|....*...
gi 767914564   1378 DMDECQDPSSCIDG-QCVNTEGSYNCFC 1404
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCEC 28
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 688-729 2.08e-13

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 65.76  E-value: 2.08e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 767914564   688 QCMHPLSVHLTKQLCCC-SVGKAWGPHCEKCPLPGTAAFKEIC 729
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1270-1312 1.25e-10

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 58.06  E-value: 1.25e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 767914564  1270 CDNVLAPNVTKQECCCTS-GVGWGDNCEifPCPVLGTAEFTEMC 1312
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSvGRAWGSPCE--LCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1446-1488 7.85e-10

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 55.75  E-value: 7.85e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 767914564  1446 VCSRPLVGkQTTYTECCCLY-GEAWGMQCALCPLKDSDDYAQLC 1488
Cdd:pfam00683    2 RCSNPLPG-NVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
1203-1244 8.04e-09

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 52.63  E-value: 8.04e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 767914564   1203 DINECEHPGLCGPQGECLNTEGSFHCVCQQGFSisaDGRTCE 1244
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1203-1244 5.40e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 5.40e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 767914564 1203 DINECEHPGLCGPQGECLNTEGSFHCVCQQGFSisadGRTCE 1244
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1121-1161 2.31e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.40  E-value: 2.31e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 767914564   1121 DIDECQHRHLCAHG-QCRNTEGSFQCVCDQGYRAsglGDHCE 1161
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1121-1161 8.06e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 8.06e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 767914564 1121 DIDECQHRHLC-AHGQCRNTEGSFQCVCDQGYRasglGDHCE 1161
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1080-1111 8.51e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 8.51e-07
                            10        20        30
                    ....*....|....*....|....*....|...
gi 767914564   1080 DIDECQQGNLCVNG-QCKNTEGSFRCTCGQGYQ 1111
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1080-1112 1.99e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 1.99e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 767914564 1080 DIDECQQGNLCVN-GQCKNTEGSFRCTCGQGYQL 1112
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
1039-1078 3.39e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 3.39e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 767914564   1039 DVDECLEPNVCANG-DCSNLEGSYMCSCHKGYTrtpDHKHC 1078
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
916-957 9.50e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 9.50e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767914564    916 DIDECTQVqHLCSQG-RCENTEGSFLCICPAGFmasEEGTNCI 957
Cdd:smart00179    1 DIDECASG-NPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
626-656 9.88e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 9.88e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 767914564    626 DINECQLQGVCPNG-ECLNTMGSYRCTCKIGF 656
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1162-1192 1.78e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.99  E-value: 1.78e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767914564  1162 DINECLEDKSVCQR-GDCINTAGSYDCTCPDG 1192
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1039-1070 2.62e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 2.62e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 767914564 1039 DVDECLEPNVCAN-GDCSNLEGSYMCSCHKGYT 1070
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1162-1202 2.66e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 2.66e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 767914564   1162 DINECLEDkSVCQRG-DCINTAGSYDCTCPDGFQldDNKTCQ 1202
Cdd:smart00179    1 DIDECASG-NPCQNGgTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 626-656 3.74e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.74e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 767914564  626 DINECQLQGVCPN-GECLNTMGSYRCTCKIGF 656
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGY 32
EGF_CA pfam07645
Calcium-binding EGF domain;
916-946 7.19e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 41.45  E-value: 7.19e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767914564   916 DIDECTQVQHLCSQ-GRCENTEGSFLCICPAG 946
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1573-1607 7.93e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 7.93e-05
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 767914564   1573 DVNECDELNNrmslCKN-AKCINTDGSYKCLCLPGY 1607
Cdd:smart00179    1 DIDECASGNP----CQNgGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 916-957 1.18e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 1.18e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 767914564  916 DIDECTQvQHLCS-QGRCENTEGSFLCICPAGFmaseEGTNCI 957
Cdd:cd00054     1 DIDECAS-GNPCQnGGTCVNTVGSYRCSCPPGY----TGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
958-998 1.43e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.43e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 767914564    958 DVDECLRPDVCGEG-HCVNTVGAFRCEyCDSGYrmTQRGRCE 998
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCE-CPPGY--TDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1573-1607 2.30e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 2.30e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 767914564 1573 DVNECDELNNrmslCKN-AKCINTDGSYKCLCLPGY 1607
Cdd:cd00054     1 DIDECASGNP----CQNgGTCVNTVGSYRCSCPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1162-1202 3.91e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 3.91e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 767914564 1162 DINEClEDKSVCQR-GDCINTAGSYDCTCPDGFQLddnKTCQ 1202
Cdd:cd00054     1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPGYTG---RNCE 38
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 567-602 4.00e-04

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 39.57  E-value: 4.00e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767914564   567 QCGKALPG-LSKQEDCCGTVGTSWGfNKCQKCPKKPS 602
Cdd:pfam00683    2 RCSNPLPGnVTKSECCCTSVGRAWG-SPCELCPPPGT 37
PHA03247 PHA03247
large tegument protein UL36; Provisional
 742-869 4.86e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 4.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914564  742 RRRPIHHHVGKGPVfvkPKNTQPVAKsthPPPLPAKEEPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPG 821
Cdd:PHA03247 2878 PARPPVRRLARPAV---SRSTESFAL---PPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAG 2951

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767914564  822 QPQLSPGISTIHLHPQFPG---IVIEKTSPPVPVEVAPEASTSSASQVIAP 869
Cdd:PHA03247 2952 AGEPSGAVPQPWLGALVPGrvaVPRFRVPQPAPSREAPASSTPPLTGHSLS 3002
EGF_CA pfam07645
Calcium-binding EGF domain;
1573-1606 7.82e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.37  E-value: 7.82e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 767914564  1573 DVNECDELNNrmsLC-KNAKCINTDGSYKCLCLPG 1606
Cdd:pfam07645    1 DVDECATGTH---NCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 958-990 1.29e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.29e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 767914564  958 DVDECLRPDVCGEGH-CVNTVGAFRCEyCDSGYR 990
Cdd:cd00054     1 DIDECASGNPCQNGGtCVNTVGSYRCS-CPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
626-655 1.41e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.60  E-value: 1.41e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767914564   626 DINEC-QLQGVCP-NGECLNTMGSYRCTCKIG 655
Cdd:pfam07645    1 DVDECaTGTHNCPaNTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 999-1032 1.52e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.52e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767914564  999 DIDECLNPSTC-PDEQCVNSPGSYQCVpCTEGFRG 1032
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYTG 34
EGF_CA pfam07645
Calcium-binding EGF domain;
1121-1150 2.52e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 2.52e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767914564  1121 DIDEC-QHRHLC-AHGQCRNTEGSFQCVCDQG 1150
Cdd:pfam07645    1 DVDECaTGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
999-1031 3.30e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 3.30e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 767914564    999 DIDECLNPSTC-PDEQCVNSPGSYQCVpCTEGFR 1031
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
1080-1109 6.05e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.68  E-value: 6.05e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767914564  1080 DIDECQQG-NLC-VNGQCKNTEGSFRCTCGQG 1109
Cdd:pfam07645    1 DVDECATGtHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1203-1233 6.17e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.68  E-value: 6.17e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767914564  1203 DINECEHPG-LCGPQGECLNTEGSFHCVCQQG 1233
Cdd:pfam07645    1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1039-1065 7.15e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.68  E-value: 7.15e-03
                           10        20
                   ....*....|....*....|....*....
gi 767914564  1039 DVDECLEP-NVC-ANGDCSNLEGSYMCSC 1065
Cdd:pfam07645    1 DVDECATGtHNCpANTVCVNTIGSFECRC 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
1378-1404 8.58e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 8.58e-03
                            10        20
                    ....*....|....*....|....*...
gi 767914564   1378 DMDECQDPSSCIDG-QCVNTEGSYNCFC 1404
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCEC 28
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 688-729 2.08e-13

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 65.76  E-value: 2.08e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 767914564   688 QCMHPLSVHLTKQLCCC-SVGKAWGPHCEKCPLPGTAAFKEIC 729
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1270-1312 1.25e-10

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 58.06  E-value: 1.25e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 767914564  1270 CDNVLAPNVTKQECCCTS-GVGWGDNCEifPCPVLGTAEFTEMC 1312
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSvGRAWGSPCE--LCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1446-1488 7.85e-10

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 55.75  E-value: 7.85e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 767914564  1446 VCSRPLVGkQTTYTECCCLY-GEAWGMQCALCPLKDSDDYAQLC 1488
Cdd:pfam00683    2 RCSNPLPG-NVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
1203-1244 8.04e-09

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 52.63  E-value: 8.04e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 767914564   1203 DINECEHPGLCGPQGECLNTEGSFHCVCQQGFSisaDGRTCE 1244
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1203-1244 5.40e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 5.40e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 767914564 1203 DINECEHPGLCGPQGECLNTEGSFHCVCQQGFSisadGRTCE 1244
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1121-1161 2.31e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.40  E-value: 2.31e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 767914564   1121 DIDECQHRHLCAHG-QCRNTEGSFQCVCDQGYRAsglGDHCE 1161
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1121-1161 8.06e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 8.06e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 767914564 1121 DIDECQHRHLC-AHGQCRNTEGSFQCVCDQGYRasglGDHCE 1161
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1080-1111 8.51e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 8.51e-07
                            10        20        30
                    ....*....|....*....|....*....|...
gi 767914564   1080 DIDECQQGNLCVNG-QCKNTEGSFRCTCGQGYQ 1111
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1080-1112 1.99e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 1.99e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 767914564 1080 DIDECQQGNLCVN-GQCKNTEGSFRCTCGQGYQL 1112
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
1039-1078 3.39e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 3.39e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 767914564   1039 DVDECLEPNVCANG-DCSNLEGSYMCSCHKGYTrtpDHKHC 1078
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
916-957 9.50e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 9.50e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767914564    916 DIDECTQVqHLCSQG-RCENTEGSFLCICPAGFmasEEGTNCI 957
Cdd:smart00179    1 DIDECASG-NPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
626-656 9.88e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 9.88e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 767914564    626 DINECQLQGVCPNG-ECLNTMGSYRCTCKIGF 656
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1162-1192 1.78e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.99  E-value: 1.78e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767914564  1162 DINECLEDKSVCQR-GDCINTAGSYDCTCPDG 1192
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1039-1070 2.62e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 2.62e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 767914564 1039 DVDECLEPNVCAN-GDCSNLEGSYMCSCHKGYT 1070
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1162-1202 2.66e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 2.66e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 767914564   1162 DINECLEDkSVCQRG-DCINTAGSYDCTCPDGFQldDNKTCQ 1202
Cdd:smart00179    1 DIDECASG-NPCQNGgTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 626-656 3.74e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.74e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 767914564  626 DINECQLQGVCPN-GECLNTMGSYRCTCKIGF 656
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGY 32
EGF_CA pfam07645
Calcium-binding EGF domain;
916-946 7.19e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 41.45  E-value: 7.19e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767914564   916 DIDECTQVQHLCSQ-GRCENTEGSFLCICPAG 946
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1573-1607 7.93e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 7.93e-05
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 767914564   1573 DVNECDELNNrmslCKN-AKCINTDGSYKCLCLPGY 1607
Cdd:smart00179    1 DIDECASGNP----CQNgGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 916-957 1.18e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 1.18e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 767914564  916 DIDECTQvQHLCS-QGRCENTEGSFLCICPAGFmaseEGTNCI 957
Cdd:cd00054     1 DIDECAS-GNPCQnGGTCVNTVGSYRCSCPPGY----TGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
958-998 1.43e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.43e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 767914564    958 DVDECLRPDVCGEG-HCVNTVGAFRCEyCDSGYrmTQRGRCE 998
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCE-CPPGY--TDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1573-1607 2.30e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 2.30e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 767914564 1573 DVNECDELNNrmslCKN-AKCINTDGSYKCLCLPGY 1607
Cdd:cd00054     1 DIDECASGNP----CQNgGTCVNTVGSYRCSCPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1162-1202 3.91e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 3.91e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 767914564 1162 DINEClEDKSVCQR-GDCINTAGSYDCTCPDGFQLddnKTCQ 1202
Cdd:cd00054     1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPGYTG---RNCE 38
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 567-602 4.00e-04

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 39.57  E-value: 4.00e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767914564   567 QCGKALPG-LSKQEDCCGTVGTSWGfNKCQKCPKKPS 602
Cdd:pfam00683    2 RCSNPLPGnVTKSECCCTSVGRAWG-SPCELCPPPGT 37
PHA03247 PHA03247
large tegument protein UL36; Provisional
 742-869 4.86e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 4.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914564  742 RRRPIHHHVGKGPVfvkPKNTQPVAKsthPPPLPAKEEPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPG 821
Cdd:PHA03247 2878 PARPPVRRLARPAV---SRSTESFAL---PPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAG 2951

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767914564  822 QPQLSPGISTIHLHPQFPG---IVIEKTSPPVPVEVAPEASTSSASQVIAP 869
Cdd:PHA03247 2952 AGEPSGAVPQPWLGALVPGrvaVPRFRVPQPAPSREAPASSTPPLTGHSLS 3002
EGF_CA pfam07645
Calcium-binding EGF domain;
1573-1606 7.82e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.37  E-value: 7.82e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 767914564  1573 DVNECDELNNrmsLC-KNAKCINTDGSYKCLCLPG 1606
Cdd:pfam07645    1 DVDECATGTH---NCpANTVCVNTIGSFECRCPDG 32
EGF smart00181
Epidermal growth factor-like domain;
1083-1113 8.08e-04

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 38.27  E-value: 8.08e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 767914564   1083 ECQQGNLCVNGQCKNTEGSFRCTCGQGYQLS 1113
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGD 31
EGF smart00181
Epidermal growth factor-like domain;
1124-1152 1.23e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 37.88  E-value: 1.23e-03
                            10        20
                    ....*....|....*....|....*....
gi 767914564   1124 ECQHRHLCAHGQCRNTEGSFQCVCDQGYR 1152
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYT 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 958-990 1.29e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.29e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 767914564  958 DVDECLRPDVCGEGH-CVNTVGAFRCEyCDSGYR 990
Cdd:cd00054     1 DIDECASGNPCQNGGtCVNTVGSYRCS-CPPGYT 33
EGF smart00181
Epidermal growth factor-like domain;
629-661 1.32e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 37.88  E-value: 1.32e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 767914564    629 ECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPT 661
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGDKR 33
EGF_CA pfam07645
Calcium-binding EGF domain;
626-655 1.41e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.60  E-value: 1.41e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767914564   626 DINEC-QLQGVCP-NGECLNTMGSYRCTCKIG 655
Cdd:pfam07645    1 DVDECaTGTHNCPaNTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 999-1032 1.52e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.52e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767914564  999 DIDECLNPSTC-PDEQCVNSPGSYQCVpCTEGFRG 1032
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYTG 34
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1206-1235 2.25e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.07  E-value: 2.25e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 767914564 1206 ECEHPGLCGPQGECLNTEGSFHCVCQQGFS 1235
Cdd:cd00053     1 ECAASNPCSNGGTCVNTPGSYRCVCPPGYT 30
EGF smart00181
Epidermal growth factor-like domain;
1042-1070 2.51e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 37.11  E-value: 2.51e-03
                            10        20
                    ....*....|....*....|....*....
gi 767914564   1042 ECLEPNVCANGDCSNLEGSYMCSCHKGYT 1070
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYT 29
EGF_CA pfam07645
Calcium-binding EGF domain;
1121-1150 2.52e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 2.52e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767914564  1121 DIDEC-QHRHLC-AHGQCRNTEGSFQCVCDQG 1150
Cdd:pfam07645    1 DVDECaTGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
999-1031 3.30e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 3.30e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 767914564    999 DIDECLNPSTC-PDEQCVNSPGSYQCVpCTEGFR 1031
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYT 33
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 1187-1206 4.93e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 35.85  E-value: 4.93e-03
                           10        20
                   ....*....|....*....|.
gi 767914564  1187 CTCPDGFQLD-DNKTCQDINE 1206
Cdd:pfam12662    2 CSCPPGYQLDpDGRTCVDIDE 22
EGF_CA pfam07645
Calcium-binding EGF domain;
1080-1109 6.05e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.68  E-value: 6.05e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767914564  1080 DIDECQQG-NLC-VNGQCKNTEGSFRCTCGQG 1109
Cdd:pfam07645    1 DVDECATGtHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1203-1233 6.17e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.68  E-value: 6.17e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767914564  1203 DINECEHPG-LCGPQGECLNTEGSFHCVCQQG 1233
Cdd:pfam07645    1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 910-953 6.44e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 40.06  E-value: 6.44e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 767914564  910 QQRKCVDIDECTQVQHLCSQGrCENTEGSFLCICPAGFMASEEG 953
Cdd:cd01475   180 QGKICVVPDLCATLSHVCQQV-CISTPGSYLCACTEGYALLEDN 222
EGF_CA pfam07645
Calcium-binding EGF domain;
1039-1065 7.15e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.68  E-value: 7.15e-03
                           10        20
                   ....*....|....*....|....*....
gi 767914564  1039 DVDECLEP-NVC-ANGDCSNLEGSYMCSC 1065
Cdd:pfam07645    1 DVDECATGtHNCpANTVCVNTIGSFECRC 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
1378-1404 8.58e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 8.58e-03
                            10        20
                    ....*....|....*....|....*...
gi 767914564   1378 DMDECQDPSSCIDG-QCVNTEGSYNCFC 1404
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCEC 28
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 1063-1083 9.06e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 35.08  E-value: 9.06e-03
                           10        20
                   ....*....|....*....|.
gi 767914564  1063 CSCHKGYTRTPDHKHCRDIDE 1083
Cdd:pfam12662    2 CSCPPGYQLDPDGRTCVDIDE 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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