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Conserved domains on  [gi|767915025|ref|XP_011531330|]
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ATP-binding cassette sub-family G member 5 isoform X9 [Homo sapiens]

Protein Classification

ABC transporter G family protein( domain architecture ID 1000947)

ABC transporter G (ABCG) family protein may be involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
3a01204 super family cl36780
The Eye Pigment Precursor Transporter (EPP) Family protein; [Transport and binding proteins, ...
2-366 5.41e-34

The Eye Pigment Precursor Transporter (EPP) Family protein; [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00955:

Pssm-ID: 273361 [Multi-domain]  Cd Length: 617  Bit Score: 132.48  E-value: 5.41e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915025    2 LDFFNDCGYPCPEHSNPFDFYMDLTSVDtqsKEREIETSKRVQMIESAYKKSAICHKTLKNIeRMKHLKTLPMV-----P 76
Cdd:TIGR00955 255 VPFFSDLGHPCPENYNPADFYVQVLAVI---PGSENESRERIEKICDSFAVSDIGRDMLVNT-NLWSGKAGGLVkdsenM 330
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915025   77 FKTKDSPGVFSKLGVLLRRVTRNLVRNKLAVITRLLQNLIMGLF--LLFFVLRVRSnvlKGaIQDRVGLLYQFVGATPYT 154
Cdd:TIGR00955 331 EGIGYNASWWTQFYALLKRSWLSVLRDPLLLKVRLIQTMMTAILigLIYLGQGLTQ---KG-VQNINGALFLFLTNMTFQ 406
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915025  155 GMLNAVNLFPVLRAVSDQESQDGLYQKWQMMLAYALHVLPFSVVATMIFSSVCYWTLGLHPEVARFGYFSAALLAPHLIG 234
Cdd:TIGR00955 407 NVFPVINVFTAELPVFLRETRSGLYRVSAYFLAKTIAELPLFIILPALFTSITYWMIGLRSGATHFLTFLFLVTLVANVA 486
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915025  235 EFLTLVLLGIVQNPNIVNSVVALLSIAgVLVGSGFLRNIQEMPIPFKIISYFTFQKYCSEILVVNEFYGL-NFTCGSSNv 313
Cdd:TIGR00955 487 TSFGYLISCAFSSTSMALTVGPPFVIP-FLLFGGFFINSDSIPVYFKWLSYLSWFRYGNEGLLINQWSDVdNIECTSAN- 564
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767915025  314 svTTNPMCAFTQGIQfieKTCPGATSRFTMNFLILYSFIPALVILGIVVFKIR 366
Cdd:TIGR00955 565 --TTGPCPSSGEVIL---ETLSFRNADLYLDLIGLVILIFFFRLLAYFALRIR 612
 
Name Accession Description Interval E-value
3a01204 TIGR00955
The Eye Pigment Precursor Transporter (EPP) Family protein; [Transport and binding proteins, ...
2-366 5.41e-34

The Eye Pigment Precursor Transporter (EPP) Family protein; [Transport and binding proteins, Other]


Pssm-ID: 273361 [Multi-domain]  Cd Length: 617  Bit Score: 132.48  E-value: 5.41e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915025    2 LDFFNDCGYPCPEHSNPFDFYMDLTSVDtqsKEREIETSKRVQMIESAYKKSAICHKTLKNIeRMKHLKTLPMV-----P 76
Cdd:TIGR00955 255 VPFFSDLGHPCPENYNPADFYVQVLAVI---PGSENESRERIEKICDSFAVSDIGRDMLVNT-NLWSGKAGGLVkdsenM 330
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915025   77 FKTKDSPGVFSKLGVLLRRVTRNLVRNKLAVITRLLQNLIMGLF--LLFFVLRVRSnvlKGaIQDRVGLLYQFVGATPYT 154
Cdd:TIGR00955 331 EGIGYNASWWTQFYALLKRSWLSVLRDPLLLKVRLIQTMMTAILigLIYLGQGLTQ---KG-VQNINGALFLFLTNMTFQ 406
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915025  155 GMLNAVNLFPVLRAVSDQESQDGLYQKWQMMLAYALHVLPFSVVATMIFSSVCYWTLGLHPEVARFGYFSAALLAPHLIG 234
Cdd:TIGR00955 407 NVFPVINVFTAELPVFLRETRSGLYRVSAYFLAKTIAELPLFIILPALFTSITYWMIGLRSGATHFLTFLFLVTLVANVA 486
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915025  235 EFLTLVLLGIVQNPNIVNSVVALLSIAgVLVGSGFLRNIQEMPIPFKIISYFTFQKYCSEILVVNEFYGL-NFTCGSSNv 313
Cdd:TIGR00955 487 TSFGYLISCAFSSTSMALTVGPPFVIP-FLLFGGFFINSDSIPVYFKWLSYLSWFRYGNEGLLINQWSDVdNIECTSAN- 564
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767915025  314 svTTNPMCAFTQGIQfieKTCPGATSRFTMNFLILYSFIPALVILGIVVFKIR 366
Cdd:TIGR00955 565 --TTGPCPSSGEVIL---ETLSFRNADLYLDLIGLVILIFFFRLLAYFALRIR 612
ABC2_membrane pfam01061
ABC-2 type transporter;
92-299 2.18e-18

ABC-2 type transporter;


Pssm-ID: 426023 [Multi-domain]  Cd Length: 204  Bit Score: 82.32  E-value: 2.18e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915025   92 LLRRVTRNLVRNKLAVITRLLQNLIMGLFLLFFVLRVRSnvlKGAIQDRVGLLYQFVGATPYTGMLNAVNLFPVLRAVSD 171
Cdd:pfam01061   1 LLKREFLRRWRDPSLGLWRLIQPILMALIFGTLFGNLGN---QQGGLNRPGLLFFSILFNAFSALSGISPVFEKERGVLY 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915025  172 QESQDGLYQKWQMMLAYALHVLPFSVVATMIFSSVCYWTLGLHPEVARFGYFSAALLAPHLIGEFLTLVLLGIVQNPNIV 251
Cdd:pfam01061  78 RELASPLYSPSAYVLAKILSELPLSLLQSLIFLLIVYFMVGLPPSAGRFFLFLLVLLLTALAASSLGLFISALAPSFEDA 157
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 767915025  252 NSVVALLSIAGVLVgSGFLRNIQEMPIPFKIISYFTFQKYCSEILVVN 299
Cdd:pfam01061 158 SQLGPLVLLPLLLL-SGFFIPIDSMPVWWQWIYYLNPLTYAIEALRAN 204
PLN03211 PLN03211
ABC transporter G-25; Provisional
137-325 3.55e-12

ABC transporter G-25; Provisional


Pssm-ID: 215634 [Multi-domain]  Cd Length: 659  Bit Score: 67.60  E-value: 3.55e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915025 137 IQDRVGLLY---QFVGATPYTgmlNAVNLFPVLRAVSDQESQDGLYQKWQMMLAYALHVLPFSVVATMIFSSVCYWTLGL 213
Cdd:PLN03211 435 VQDRLGLLFfisIFWGVFPSF---NSVFVFPQERAIFVKERASGMYTLSSYFMARIVGDLPMELILPTIFLTVTYWMAGL 511
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915025 214 HPEVARFGYFSAALLAPHLIGEFLTLVLLGIVQNPNIVNSVVALLSIAGVLVGsGFLrnIQEMPIPFKIISYFTFQKYCS 293
Cdd:PLN03211 512 KPELGAFLLTLLVLLGYVLVSQGLGLALGAAIMDAKKASTIVTVTMLAFVLTG-GFY--VHKLPSCMAWIKYISTTFYSY 588
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 767915025 294 EILvVNEFYG----LNFTCGSSNVSVTTNPMCAFTQ 325
Cdd:PLN03211 589 RLL-INVQYGegkrISSLLGCSLPHGSDRASCKFVE 623
 
Name Accession Description Interval E-value
3a01204 TIGR00955
The Eye Pigment Precursor Transporter (EPP) Family protein; [Transport and binding proteins, ...
2-366 5.41e-34

The Eye Pigment Precursor Transporter (EPP) Family protein; [Transport and binding proteins, Other]


Pssm-ID: 273361 [Multi-domain]  Cd Length: 617  Bit Score: 132.48  E-value: 5.41e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915025    2 LDFFNDCGYPCPEHSNPFDFYMDLTSVDtqsKEREIETSKRVQMIESAYKKSAICHKTLKNIeRMKHLKTLPMV-----P 76
Cdd:TIGR00955 255 VPFFSDLGHPCPENYNPADFYVQVLAVI---PGSENESRERIEKICDSFAVSDIGRDMLVNT-NLWSGKAGGLVkdsenM 330
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915025   77 FKTKDSPGVFSKLGVLLRRVTRNLVRNKLAVITRLLQNLIMGLF--LLFFVLRVRSnvlKGaIQDRVGLLYQFVGATPYT 154
Cdd:TIGR00955 331 EGIGYNASWWTQFYALLKRSWLSVLRDPLLLKVRLIQTMMTAILigLIYLGQGLTQ---KG-VQNINGALFLFLTNMTFQ 406
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915025  155 GMLNAVNLFPVLRAVSDQESQDGLYQKWQMMLAYALHVLPFSVVATMIFSSVCYWTLGLHPEVARFGYFSAALLAPHLIG 234
Cdd:TIGR00955 407 NVFPVINVFTAELPVFLRETRSGLYRVSAYFLAKTIAELPLFIILPALFTSITYWMIGLRSGATHFLTFLFLVTLVANVA 486
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915025  235 EFLTLVLLGIVQNPNIVNSVVALLSIAgVLVGSGFLRNIQEMPIPFKIISYFTFQKYCSEILVVNEFYGL-NFTCGSSNv 313
Cdd:TIGR00955 487 TSFGYLISCAFSSTSMALTVGPPFVIP-FLLFGGFFINSDSIPVYFKWLSYLSWFRYGNEGLLINQWSDVdNIECTSAN- 564
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767915025  314 svTTNPMCAFTQGIQfieKTCPGATSRFTMNFLILYSFIPALVILGIVVFKIR 366
Cdd:TIGR00955 565 --TTGPCPSSGEVIL---ETLSFRNADLYLDLIGLVILIFFFRLLAYFALRIR 612
ABC2_membrane pfam01061
ABC-2 type transporter;
92-299 2.18e-18

ABC-2 type transporter;


Pssm-ID: 426023 [Multi-domain]  Cd Length: 204  Bit Score: 82.32  E-value: 2.18e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915025   92 LLRRVTRNLVRNKLAVITRLLQNLIMGLFLLFFVLRVRSnvlKGAIQDRVGLLYQFVGATPYTGMLNAVNLFPVLRAVSD 171
Cdd:pfam01061   1 LLKREFLRRWRDPSLGLWRLIQPILMALIFGTLFGNLGN---QQGGLNRPGLLFFSILFNAFSALSGISPVFEKERGVLY 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915025  172 QESQDGLYQKWQMMLAYALHVLPFSVVATMIFSSVCYWTLGLHPEVARFGYFSAALLAPHLIGEFLTLVLLGIVQNPNIV 251
Cdd:pfam01061  78 RELASPLYSPSAYVLAKILSELPLSLLQSLIFLLIVYFMVGLPPSAGRFFLFLLVLLLTALAASSLGLFISALAPSFEDA 157
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 767915025  252 NSVVALLSIAGVLVgSGFLRNIQEMPIPFKIISYFTFQKYCSEILVVN 299
Cdd:pfam01061 158 SQLGPLVLLPLLLL-SGFFIPIDSMPVWWQWIYYLNPLTYAIEALRAN 204
3a01205 TIGR00956
Pleiotropic Drug Resistance (PDR) Family protein; [Transport and binding proteins, Other]
4-361 6.35e-17

Pleiotropic Drug Resistance (PDR) Family protein; [Transport and binding proteins, Other]


Pssm-ID: 273362 [Multi-domain]  Cd Length: 1394  Bit Score: 82.46  E-value: 6.35e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915025     4 FFNDCGYPCPEHSNPFDFymdLTSVdTQSKEREI--ETSKRV----QMIESAYKKS-------AICHKTLKNIERMKHLK 70
Cdd:TIGR00956  301 YFEKMGFKCPDRQTTADF---LTSL-TSPAERQIkpGYEKKVprtpQEFETYWRNSpeyaqlmKEIDEYLDRCSESDTKE 376
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915025    71 TLPMVPFKTKD------SPGVFSKLGVLLRRVTRNLVR---NKLAVITRLLQNLIMGLFLLFFVLRVRSNVLKGAIqdRV 141
Cdd:TIGR00956  377 AYRESHVAKQSkrtrpsSPYTVSFSMQVKYCLARNFLRmkgNPSFTLFMVFGNIIMALILSSVFYNLPKNTSDFYS--RG 454
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915025   142 GLLYQFVGATPYTGMLNAVNLFPVlRAVSDQESQDGLYQKWQMMLAYALHVLPFSVVATMIFSSVCYWTLGLHPEVARFG 221
Cdd:TIGR00956  455 GALFFAILFNAFSSLLEIASMYEA-RPIVEKHRKYALYHPSADAIASIISEIPFKIIESVVFNIILYFMVNFRRTAGRFF 533
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915025   222 Y-----FSAALLAPHL---IGEFLTLVLLGivqnpnivNSVVALLSIAGVLVgSGFLRNIQEMPIPFKIISYFTFQKYCS 293
Cdd:TIGR00956  534 FyllilFICTLAMSHLfrsIGAVTKTLSEA--------MTPAAILLLALSIY-TGFAIPRPSMLGWSKWIYYVNPLAYAF 604
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915025   294 EILVVNEFYGLNFTC--------GSSNVSVtTNPMCA---------FTQGIQFIEKTCPGATSRFTMNFLILYSFIPALV 356
Cdd:TIGR00956  605 ESLMVNEFHGRRFECsqyvpsggGYDNLGV-TNKVCTvvgaepgqdYVDGDDYLKLSFQYYNSHKWRNFGIIIGFTVFFF 683

                   ....*
gi 767915025   357 ILGIV 361
Cdd:TIGR00956  684 FVYIL 688
PLN03211 PLN03211
ABC transporter G-25; Provisional
137-325 3.55e-12

ABC transporter G-25; Provisional


Pssm-ID: 215634 [Multi-domain]  Cd Length: 659  Bit Score: 67.60  E-value: 3.55e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915025 137 IQDRVGLLY---QFVGATPYTgmlNAVNLFPVLRAVSDQESQDGLYQKWQMMLAYALHVLPFSVVATMIFSSVCYWTLGL 213
Cdd:PLN03211 435 VQDRLGLLFfisIFWGVFPSF---NSVFVFPQERAIFVKERASGMYTLSSYFMARIVGDLPMELILPTIFLTVTYWMAGL 511
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915025 214 HPEVARFGYFSAALLAPHLIGEFLTLVLLGIVQNPNIVNSVVALLSIAGVLVGsGFLrnIQEMPIPFKIISYFTFQKYCS 293
Cdd:PLN03211 512 KPELGAFLLTLLVLLGYVLVSQGLGLALGAAIMDAKKASTIVTVTMLAFVLTG-GFY--VHKLPSCMAWIKYISTTFYSY 588
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 767915025 294 EILvVNEFYG----LNFTCGSSNVSVTTNPMCAFTQ 325
Cdd:PLN03211 589 RLL-INVQYGegkrISSLLGCSLPHGSDRASCKFVE 623
PLN03140 PLN03140
ABC transporter G family member; Provisional
1-302 2.33e-07

ABC transporter G family member; Provisional


Pssm-ID: 215599 [Multi-domain]  Cd Length: 1470  Bit Score: 52.93  E-value: 2.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915025    1 MLDFFNDCGYPCPEHSNPFDFYMDLTS--------VDTQSKEREIETSKRVQMIESAYKKSaichktlknieRMKHLKTL 72
Cdd:PLN03140  425 ILEFFESCGFKCPERKGTADFLQEVTSkkdqeqywADRNKPYRYISVSEFAERFKSFHVGM-----------QLENELSV 493
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915025   73 PMVPFKTKDSPGVFSKLGVLLRRVTRN--------LVRNKLAVITRLLQNLIMGLFLLFFVLRVR---SNVLKGAIqdrv 141
Cdd:PLN03140  494 PFDKSQSHKAALVFSKYSVPKMELLKAcwdkewllMKRNAFVYVFKTVQIIIVAAIASTVFLRTEmhtRNEEDGAL---- 569
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915025  142 gllyqFVGATPYTGMLNAVNLFPVLRAVSDQ-----ESQDGLYQ-KWQMMLAYALHVLPFSVVATMIFSSVCYWTLGLHP 215
Cdd:PLN03140  570 -----YIGALLFSMIINMFNGFAELALMIQRlpvfyKQRDLLFHpPWTFTLPTFLLGIPISIIESVVWVVITYYSIGFAP 644
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915025  216 EVARFgyFSAALLApHLIGEF---LTLVLLGIVQNPNIVNSVVALLSIAGVLVGsGFLRNIQEMPIPFKIISYFTFQKYC 292
Cdd:PLN03140  645 EASRF--FKQLLLV-FLIQQMaagIFRLIASVCRTMIIANTGGALVLLLVFLLG-GFILPKGEIPNWWEWAYWVSPLSYG 720
                         330
                  ....*....|
gi 767915025  293 SEILVVNEFY 302
Cdd:PLN03140  721 FNALAVNEMF 730
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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