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Conserved domains on  [gi|767915204|ref|XP_011531398|]
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xanthine dehydrogenase/oxidase isoform X2 [Homo sapiens]

Protein Classification

xanthine dehydrogenase family( domain architecture ID 1000576)

xanthine dehydrogenase family similar to Homo sapiens xanthine dehydrogenase/oxidase which catalyzes the oxidation of hypoxanthine to xanthine, as well as the oxidation of xanthine to uric acid

CATH:  3.30.365.10
EC:  1.-.-.-
Gene Ontology:  GO:0016491|GO:0071949|GO:0050660|GO:0005506|GO:0051537

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN02906 super family cl33596
xanthine dehydrogenase
 23-1049 0e+00

xanthine dehydrogenase


The actual alignment was detected with superfamily member PLN02906:

Pssm-ID: 215491 [Multi-domain]  Cd Length: 1319  Bit Score: 1307.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   23 ETTLLAYLRrKLGLSGTKLGCGEGGCGACTVMLSKYDRLQNKIVHFSANACLAPICSLHHVAVTTVEGIGSTKTRLHPVQ 102
Cdd:PLN02906    1 HQTLLEYLR-DLGLTGTKLGCGEGGCGACTVMVSHYDRKTGKCVHYAVNACLAPLYSVEGMHVITVEGIGNRRDGLHPVQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  103 ERIAKSHGSQCGFCTPGIVMSMYTLLRNQPE-PTMEEIENAFQGNLCRCTGYRPILQGFRTFARDGGCCGGDGNNPNC-- 179
Cdd:PLN02906   80 EALASMHGSQCGFCTPGFIMSMYALLRSSKTpPTEEQIEECLAGNLCRCTGYRPILDAFRVFAKTDDALYTGVSSLSLqd 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  180 -----------CMNQKKDHSVSLSPSL--FKPEEFTPLD----PTQEPIFPPELLRLKDTPRKQLRFEGerVTWIQASTL 242
Cdd:PLN02906  160 gepicpstgkpCSCGSKTTSAAGTCKSdrFQPISYSEIDgswyTEKELIFPPELLLRKLTPLKLLGNGG--LTWYRPTSL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  243 KELLDLKAQHPDAKLVVGNTEIGIEMKFKNMLFPMIVCPAWIPELNSVEHGPDGISFGAACPLSIVEKTLVDAVAKLPAQ 322
Cdd:PLN02906  238 QHLLELKAEYPDAKLVVGNTEVGIEMRFKNAQYPVLISPTHVPELNAIKVKDDGLEIGAAVRLSELQNLFRKVVKERPAH 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  323 KTEVFRGVLEQLRWFAGKQVKSVASVGGNIITASPISDLNPVFMASGAKLTLVSR-GTRRTVQMDHtFFPGYRKTLLSPE 401
Cdd:PLN02906  318 ETSACKAFIEQLKWFAGTQIRNVASIGGNICTASPISDLNPLWMAAGATFVIISCdGDIRSVPASD-FFLGYRKVDLKPD 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  402 EILLSIEIPYSREGEYFSAFKQASRREDDIAKVTSGMRVLFKPGTTE--VQELALCYGGMANRTISALKTTQRQLSKLWK 479
Cdd:PLN02906  397 EILLSVFLPWTRPFEYVKEFKQAHRRDDDIAIVNAGMRVKLEEKDGEwiVSDASIAYGGVAPLSVSARKTEEFLIGKPWN 476

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  480 EELLQDVCAGLAEELHLPPDAPGGMVDFRCTLTLSFFFKFYLTVLQKL-GQENLEDKcgkLDPTFASATLLFQKDPPADV 558
Cdd:PLN02906  477 KETLQDALKVLQKDILIKEDAPGGMVEFRKSLALSFFFKFFLWVSHQLeADGSTIET---FPESHLSAAQPFPRPSSVGM 553

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  559 QLFQEVPKGQSeedmVGRPLPHLAADMQASGEAVYCDDIPRYENELSLRLVTSTRAHAKIKSIDTSEAKKVPGFVCFISA 638
Cdd:PLN02906  554 QDYETVKQGTA----VGQPEVHLSAELQVTGEAEYADDIPMPPNTLHAALVLSTKPHARILSIDDSEAKSSPGFAGIFLA 629

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  639 DDVPGSNITG-ICNDETVFAKDKVTCVGHIIGAVVADTPEHTQRAAQGVKITYEELPAIITIEDAIKNNSFY-GPELKIE 716
Cdd:PLN02906  630 KDVPGDNMIGpVVHDEELFATDVVTCVGQVIGVVVADTQENAKAAARKVKVEYEELPAILSIEEAIEAGSFHpNTERRLE 709

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  717 KGDLKKGFS--EADNVVSGEIYIGGQEHFYLETHCTIAVPKGEAGEMELFVSTQNTMKTQSFVAKMLGVPANRIVVRVKR 794
Cdd:PLN02906  710 KGDVELCFAsgQCDRIIEGEVQMGGQEHFYLEPNSSLVWTSDSGNEVHMISSTQAPQKHQKYVAHVLGLPMSKVVCKTKR 789

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  795 MGGGFGGKETRSTVVSTAVALAAYKTGRPVRCMLDRDEDMLITGGRHPFLARYKVGFMKTGTVVALEVDHFSNVGNTQDL 874
Cdd:PLN02906  790 IGGGFGGKETRSAFIAAAAAVPAYLLNRPVKLTLDRDVDMMITGQRHAFLGKYKVGFTNEGKILALDLEIYNNGGNSLDL 869

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  875 SQSIMERALFHMDNCYKIPNIRGTGRLCKTNLPSNTAFRGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKNLYKEGDLT 954
Cdd:PLN02906  870 SGAVLERAMFHSDNVYEIPNVRIVGNVCFTNFPSNTAFRGFGGPQGMLITENWIQRIAVELNKSPEEIREMNFQGEGSVT 949

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  955 HFNQKLEGFTLPRCWEECLASSQYHARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGALLHVYTDGSVLLTH 1034
Cdd:PLN02906  950 HYGQVLQHCTLPQLWDELKVSCDFLKRREEVDEFNAKNRWKKRGVAMVPTKFGISFTTKFMNQAGALVHVYTDGTVLVTH 1029

                        1050
                  ....*....|....*
gi 767915204 1035 GGTEMGQGLHTKMVQ 1049
Cdd:PLN02906 1030 GGVEMGQGLHTKVAQ 1044
 
Name Accession Description Interval E-value
PLN02906 PLN02906
xanthine dehydrogenase
 23-1049 0e+00

xanthine dehydrogenase


Pssm-ID: 215491 [Multi-domain]  Cd Length: 1319  Bit Score: 1307.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   23 ETTLLAYLRrKLGLSGTKLGCGEGGCGACTVMLSKYDRLQNKIVHFSANACLAPICSLHHVAVTTVEGIGSTKTRLHPVQ 102
Cdd:PLN02906    1 HQTLLEYLR-DLGLTGTKLGCGEGGCGACTVMVSHYDRKTGKCVHYAVNACLAPLYSVEGMHVITVEGIGNRRDGLHPVQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  103 ERIAKSHGSQCGFCTPGIVMSMYTLLRNQPE-PTMEEIENAFQGNLCRCTGYRPILQGFRTFARDGGCCGGDGNNPNC-- 179
Cdd:PLN02906   80 EALASMHGSQCGFCTPGFIMSMYALLRSSKTpPTEEQIEECLAGNLCRCTGYRPILDAFRVFAKTDDALYTGVSSLSLqd 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  180 -----------CMNQKKDHSVSLSPSL--FKPEEFTPLD----PTQEPIFPPELLRLKDTPRKQLRFEGerVTWIQASTL 242
Cdd:PLN02906  160 gepicpstgkpCSCGSKTTSAAGTCKSdrFQPISYSEIDgswyTEKELIFPPELLLRKLTPLKLLGNGG--LTWYRPTSL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  243 KELLDLKAQHPDAKLVVGNTEIGIEMKFKNMLFPMIVCPAWIPELNSVEHGPDGISFGAACPLSIVEKTLVDAVAKLPAQ 322
Cdd:PLN02906  238 QHLLELKAEYPDAKLVVGNTEVGIEMRFKNAQYPVLISPTHVPELNAIKVKDDGLEIGAAVRLSELQNLFRKVVKERPAH 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  323 KTEVFRGVLEQLRWFAGKQVKSVASVGGNIITASPISDLNPVFMASGAKLTLVSR-GTRRTVQMDHtFFPGYRKTLLSPE 401
Cdd:PLN02906  318 ETSACKAFIEQLKWFAGTQIRNVASIGGNICTASPISDLNPLWMAAGATFVIISCdGDIRSVPASD-FFLGYRKVDLKPD 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  402 EILLSIEIPYSREGEYFSAFKQASRREDDIAKVTSGMRVLFKPGTTE--VQELALCYGGMANRTISALKTTQRQLSKLWK 479
Cdd:PLN02906  397 EILLSVFLPWTRPFEYVKEFKQAHRRDDDIAIVNAGMRVKLEEKDGEwiVSDASIAYGGVAPLSVSARKTEEFLIGKPWN 476

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  480 EELLQDVCAGLAEELHLPPDAPGGMVDFRCTLTLSFFFKFYLTVLQKL-GQENLEDKcgkLDPTFASATLLFQKDPPADV 558
Cdd:PLN02906  477 KETLQDALKVLQKDILIKEDAPGGMVEFRKSLALSFFFKFFLWVSHQLeADGSTIET---FPESHLSAAQPFPRPSSVGM 553

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  559 QLFQEVPKGQSeedmVGRPLPHLAADMQASGEAVYCDDIPRYENELSLRLVTSTRAHAKIKSIDTSEAKKVPGFVCFISA 638
Cdd:PLN02906  554 QDYETVKQGTA----VGQPEVHLSAELQVTGEAEYADDIPMPPNTLHAALVLSTKPHARILSIDDSEAKSSPGFAGIFLA 629

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  639 DDVPGSNITG-ICNDETVFAKDKVTCVGHIIGAVVADTPEHTQRAAQGVKITYEELPAIITIEDAIKNNSFY-GPELKIE 716
Cdd:PLN02906  630 KDVPGDNMIGpVVHDEELFATDVVTCVGQVIGVVVADTQENAKAAARKVKVEYEELPAILSIEEAIEAGSFHpNTERRLE 709

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  717 KGDLKKGFS--EADNVVSGEIYIGGQEHFYLETHCTIAVPKGEAGEMELFVSTQNTMKTQSFVAKMLGVPANRIVVRVKR 794
Cdd:PLN02906  710 KGDVELCFAsgQCDRIIEGEVQMGGQEHFYLEPNSSLVWTSDSGNEVHMISSTQAPQKHQKYVAHVLGLPMSKVVCKTKR 789

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  795 MGGGFGGKETRSTVVSTAVALAAYKTGRPVRCMLDRDEDMLITGGRHPFLARYKVGFMKTGTVVALEVDHFSNVGNTQDL 874
Cdd:PLN02906  790 IGGGFGGKETRSAFIAAAAAVPAYLLNRPVKLTLDRDVDMMITGQRHAFLGKYKVGFTNEGKILALDLEIYNNGGNSLDL 869

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  875 SQSIMERALFHMDNCYKIPNIRGTGRLCKTNLPSNTAFRGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKNLYKEGDLT 954
Cdd:PLN02906  870 SGAVLERAMFHSDNVYEIPNVRIVGNVCFTNFPSNTAFRGFGGPQGMLITENWIQRIAVELNKSPEEIREMNFQGEGSVT 949

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  955 HFNQKLEGFTLPRCWEECLASSQYHARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGALLHVYTDGSVLLTH 1034
Cdd:PLN02906  950 HYGQVLQHCTLPQLWDELKVSCDFLKRREEVDEFNAKNRWKKRGVAMVPTKFGISFTTKFMNQAGALVHVYTDGTVLVTH 1029

                        1050
                  ....*....|....*
gi 767915204 1035 GGTEMGQGLHTKMVQ 1049
Cdd:PLN02906 1030 GGVEMGQGLHTKVAQ 1044
mam_aldehyde_ox TIGR02969
aldehyde oxidase; Members of this family are mammalian aldehyde oxidase (EC 1.2.3.1) isozymes, ...
 5-1053 0e+00

aldehyde oxidase; Members of this family are mammalian aldehyde oxidase (EC 1.2.3.1) isozymes, closely related to xanthine dehydrogenase/oxidase.


Pssm-ID: 132014 [Multi-domain]  Cd Length: 1330  Bit Score: 1142.43  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204     5 KLVFFVNGRKVVEKNADPETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSKYDRLQNKIVHFSANACLAPICSLHHVA 84
Cdd:TIGR02969    2 ELLFYVNGRKVVEKNVDPETMLLPYLRKKLRLTGTKYGCGGGGCGACTVMISRYNPSTKSIRHHPVNACLTPICSLYGAA 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204    85 VTTVEGIGSTKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNQPEPTMEEIENAFQGNLCRCTGYRPILQGFRTFA 164
Cdd:TIGR02969   82 VTTVEGIGSTRTRLHPVQERIAKCHGTQCGFCTPGMVMSMYALLRNHPEPTLDQLTDALGGNLCRCTGYRPIIDACKTFC 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   165 RDGGCCGGDGNNPnCCMNQKKDHSVSL------SPSLFKPEEFTPLDPTQEPIFPPELLRLKDT-PRKQLRFEGERVTWI 237
Cdd:TIGR02969  162 KTSGCCQSKENGV-CCLDQGINGLPEFeegdetSPELFSEEEFLPLDPTQELIFPPELMRMAEKqPQRTRVFYSERMMWI 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   238 QASTLKELLDLKAQHPDAKLVVGNTEIGIEMKFKNMLFPMIVCPAWIPELNSVEHGPDGISFGAACPLSIVEKTLVDAVA 317
Cdd:TIGR02969  241 SPVTLKELLEAKFKYPQAPVVMGNTSVGPEVKFKGVFHPVIISPDRIEELSVVNHTGDGLTLGAGLSLAQVKDILADVVQ 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   318 KLPAQKTEVFRGVLEQLRWFAGKQVKSVASVGGNIITASPISDLNPVFMASGAKLTLVSRGTRRTVQMDHTFFPGYRKTL 397
Cdd:TIGR02969  321 KLPEETTQTYRALLKHLGTLAGSQIRNMASLGGHIISRHLDSDLNPLLAVGNCTLNLLSKEGKRQIPLSEQFLSKCPDAD 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   398 LSPEEILLSIEIPYSREGEYFSAFKQASRREDDIAKVTSGMRVLFKPGTTEVQELALCYGGMANRTISALKTTQRQLSKL 477
Cdd:TIGR02969  401 LKPQEILVSVNIPYSRKWEFVSAFRQAQRQQNALAIVNSGMRVFFGEGDGIIRELSISYGGVGPTTICAKNSCQKLIGRP 480

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   478 WKEELLQDVCAGLAEELHLPPDAPGGMVDFRCTLTLSFFFKFYLTVLQKLGQEN------LEDKcgkldptFASATLLFQ 551
Cdd:TIGR02969  481 WNEEMLDTACRLILDEVSLAGSAPGGKVEFKRTLIISFLFKFYLEVSQILKRMDpghypsLADK-------YESALEDLH 553

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   552 KDPPADVQLFQEVPKGQSEEDMVGRPLPHLAADMQASGEAVYCDDIPRYENELSLRLVTSTRAHAKIKSIDTSEAKKVPG 631
Cdd:TIGR02969  554 SKHHWSTLKHQNVDSMQLPQDPIGHPIMHLSGVKHATGEAIYCDDMPAVDQELFLTFVTSSRAHAKIVSIDLSEALSLPG 633

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   632 FVCFISADDVPGSNITGIcndETVFAKDKVTCVGHIIGAVVADTPEHTQRAAQGVKITYEEL-PAIITIEDAIKNNSFYG 710
Cdd:TIGR02969  634 VVDIITAEHLQDANTFGT---EKLLATDKVHCVGQLVCAVIADSEVQAKQAAKHVKIVYRDLePLILTIEEAIQHKSFFE 710

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   711 PELKIEKGDLKKGFSEADNVVSGEIYIGGQEHFYLETHCTIAVPKGEAGEMELFVSTQNTMKTQSFVAKMLGVPANRIVV 790
Cdd:TIGR02969  711 PERKLEYGNVDEAFKVVDQILEGEIHMGGQEHFYMETQSMLVVPKGEDQEMDVYVSTQFPKYIQDIVAATLKLPVNKVMC 790

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   791 RVKRMGGGFGGKETRSTVVSTAVALAAYKTGRPVRCMLDRDEDMLITGGRHPFLARYKVGFMKTGTVVALEVDHFSNVGN 870
Cdd:TIGR02969  791 HVRRVGGAFGGKVGKTSIMAAITAFAANKHGRAVRCTLERGEDMLITGGRHPYLGKYKAGFMNDGRIVALDVEHYSNGGS 870

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   871 TQDLSQSIMERALFHMDNCYKIPNIRGTGRLCKTNLPSNTAFRGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKNLYKE 950
Cdd:TIGR02969  871 SLDESLWVIEMGLLKMDNAYKFPNLRCRGWACRTNLPSNTAFRGFGFPQAGLITEACITEVAAKCGLSPEKVRTINMYKE 950

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   951 GDLTHFNQKLEGFTLPRCWEECLASSQYHARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGALLHVYTDGSV 1030
Cdd:TIGR02969  951 IDQTPYKQEINAKNLFQCWRECMAKSSYSERKVAVEKFNAENYWKKRGLAVIPLKFPVGLGSVAMGQAAALVHIYLDGSV 1030

                         1050      1060
                   ....*....|....*....|...
gi 767915204  1031 LLTHGGTEMGQGLHTKMVQELAR 1053
Cdd:TIGR02969 1031 LVTHGGIEMGQGVHTKMIQVVSR 1053
XdhB COG4631
Xanthine dehydrogenase, molybdopterin-binding subunit XdhB [Nucleotide transport and ...
 574-1049 0e+00

Xanthine dehydrogenase, molybdopterin-binding subunit XdhB [Nucleotide transport and metabolism];


Pssm-ID: 443669 [Multi-domain]  Cd Length: 769  Bit Score: 720.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  574 VGRPLPHLAADMQASGEAVYCDDIPRYENELSLRLVTSTRAHAKIKSIDTSEAKKVPGFVCFISADDVPGSN-ITGICND 652
Cdd:COG4631    14 VGKSLPHESARLHVTGEARYIDDLPEPAGTLHAAPGLSPVAHARILSIDLSAVRAAPGVVAVLTAADIPGENdIGPIIHD 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  653 ETVFAKDKVTCVGHIIGAVVADTPEHTQRAAQGVKITYEELPAIITIEDAIKNNSFYGPELKIEKGDLKKGFSEADNVVS 732
Cdd:COG4631    94 EPLLADGEVEYVGQPVFAVVAESREAARRAARLAKIEYEELPAILTIEEALAAGSFVLPPHTLRRGDADAALAAAPHRLE 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  733 GEIYIGGQEHFYLETHCTIAVPkGEAGEMELFVSTQNTMKTQSFVAKMLGVPANRIVVRVKRMGGGFGGKETRSTVVSTA 812
Cdd:COG4631   174 GEFEIGGQEHFYLEGQIALAIP-GEDGGMLVHSSTQHPSEVQHLVAHVLGVPMHAVTVEVRRMGGGFGGKESQAALFAAL 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  813 VALAAYKTGRPVRCMLDRDEDMLITGGRHPFLARYKVGFMKTGTVVALEVDHFSNVGNTQDLSQSIMERALFHMDNCYKI 892
Cdd:COG4631   253 AALAARKTGRPVKLRLDRDDDMVMTGKRHPFRIDYEVGFDDDGRILGLDITLAARCGWSADLSGPVADRAMFHADNAYYL 332

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  893 PNIRGTGRLCKTNLPSNTAFRGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKNLY--KEGDLTHFNQKLEGFTLPRCWE 970
Cdd:COG4631   333 PAVRITGHRCKTNTQSNTAFRGFGGPQGMLAIERVIDDIARALGLDPLDVRRRNFYgpAERNTTPYGQPVEDNILHELVD 412

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767915204  971 ECLASSQYHARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGALLHVYTDGSVLLTHGGTEMGQGLHTKMVQ 1049
Cdd:COG4631   413 ELEESSDYAARRAAIAAFNAASPVLKRGLALTPVKFGISFTATHLNQAGALVHVYTDGSVQLNHGGTEMGQGLHTKVAQ 491
MoCoBD_1 pfam02738
Molybdopterin cofactor-binding domain;
700-947 1.57e-124

Molybdopterin cofactor-binding domain;


Pssm-ID: 460671 [Multi-domain]  Cd Length: 244  Bit Score: 379.49  E-value: 1.57e-124
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   700 EDAIKNNSFygpelKIEKGDLKKGFSEADNVVSGEIYIGGQEHFYLETHCTIAVPKGEAGEMELFVSTQNTMKTQSFVAK 779
Cdd:pfam02738    3 EEPPNNVAF-----HREKGDVEAAFAEADHVVEGEYRTGRQEHFYMETRAALAVPDDEDGRLTVYSSTQGPHLVRRLVAR 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   780 MLGVPANRIVVRVKRMGGGFGGKeTRSTVVSTAVALAAYKTGRPVRCMLDRDEDMLITGGRHPFLARYKVGFMKTGTVVA 859
Cdd:pfam02738   78 VLGIPENKVRVIVPRVGGGFGGK-TQSYPEEALAALAARKTGRPVKWVLDREEDMLATGHRHPFLIKYKVGADKDGKILA 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   860 LEVDHFSNVGNTQDLSQSIMERALFHMDNCYKIPNIRGTGRLCKTNLPSNTAFRGFGGPQGMLIAECWMSEVAVTCGMPA 939
Cdd:pfam02738  157 LDVDLYADGGAYADLSPAVPERALSHLDGPYKIPNVRVDGRAVYTNTPPNGAFRGFGRPQGMFALERLMDELAEELGMDP 236


                   ....*...
gi 767915204   940 EEVRRKNL 947
Cdd:pfam02738  237 LELRRRNL 244
Ald_Xan_dh_C smart01008
Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Aldehyde oxidase catalyses ...
 588-694 1.40e-41

Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Aldehyde oxidase catalyses the conversion of an aldehyde in the presence of oxygen and water to an acid and hydrogen peroxide. The enzyme is a homodimer, and requires FAD, molybdenum and two 2FE-2S clusters as cofactors. Xanthine dehydrogenase catalyses the hydrogenation of xanthine to urate, and also requires FAD, molybdenum and two 2FE-2S clusters as cofactors. This activity is often found in a bifunctional enzyme with xanthine oxidase activity too. The enzyme can be converted from the dehydrogenase form to the oxidase form irreversibly by proteolysis or reversibly through oxidation of sulphydryl groups.


Pssm-ID: 214971 [Multi-domain]  Cd Length: 107  Bit Score: 147.66  E-value: 1.40e-41
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204    588 SGEAVYCDDIpRYENELSLRLVTSTRAHAKIKSIDTSEAKKVPGFVCFISADDVPGSNITG-ICNDETVFAKDKVTCVGH 666
Cdd:smart01008    1 TGEARYGDDI-RLPGMLHAAVVRSPVAHARIKSIDTSAARAMPGVVAVLTAKDVPGLNDFGpLGPDEPVLADDKVRYVGQ 79

                            90       100
                    ....*....|....*....|....*...
gi 767915204    667 IIGAVVADTPEHTQRAAQGVKITYEELP 694
Cdd:smart01008   80 PVAAVVAETEEAARDAAEAVKVEYEELP 107
glyceraldDH_gamma NF041020
glyceraldehyde dehydrogenase subunit gamma;
10-165 8.20e-29

glyceraldehyde dehydrogenase subunit gamma;


Pssm-ID: 468949 [Multi-domain]  Cd Length: 162  Bit Score: 113.35  E-value: 8.20e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   10 VNGrKVVEKNADPETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSKYdrlqnkivhfSANACLAPICSLHHVAVTTVE 89
Cdd:NF041020   15 VNG-VWYEAEVEPRKLLVHFLRDDLGFTGTHVGCDTSTCGACTVIMNGK----------SVKSCTVLAVQADGAEITTIE 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767915204   90 GIGStKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNQPEPTMEEIENAFQGNLCRCTGYRPILQGFRTFAR 165
Cdd:NF041020   84 GLSK-DGKLHPIQEAFWENHALQCGYCTPGMIMQAYFLLKENPNPTEEEIRDGIHGNLCRCTGYQNIVKAVKEASQ 158
 
Name Accession Description Interval E-value
PLN02906 PLN02906
xanthine dehydrogenase
 23-1049 0e+00

xanthine dehydrogenase


Pssm-ID: 215491 [Multi-domain]  Cd Length: 1319  Bit Score: 1307.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   23 ETTLLAYLRrKLGLSGTKLGCGEGGCGACTVMLSKYDRLQNKIVHFSANACLAPICSLHHVAVTTVEGIGSTKTRLHPVQ 102
Cdd:PLN02906    1 HQTLLEYLR-DLGLTGTKLGCGEGGCGACTVMVSHYDRKTGKCVHYAVNACLAPLYSVEGMHVITVEGIGNRRDGLHPVQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  103 ERIAKSHGSQCGFCTPGIVMSMYTLLRNQPE-PTMEEIENAFQGNLCRCTGYRPILQGFRTFARDGGCCGGDGNNPNC-- 179
Cdd:PLN02906   80 EALASMHGSQCGFCTPGFIMSMYALLRSSKTpPTEEQIEECLAGNLCRCTGYRPILDAFRVFAKTDDALYTGVSSLSLqd 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  180 -----------CMNQKKDHSVSLSPSL--FKPEEFTPLD----PTQEPIFPPELLRLKDTPRKQLRFEGerVTWIQASTL 242
Cdd:PLN02906  160 gepicpstgkpCSCGSKTTSAAGTCKSdrFQPISYSEIDgswyTEKELIFPPELLLRKLTPLKLLGNGG--LTWYRPTSL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  243 KELLDLKAQHPDAKLVVGNTEIGIEMKFKNMLFPMIVCPAWIPELNSVEHGPDGISFGAACPLSIVEKTLVDAVAKLPAQ 322
Cdd:PLN02906  238 QHLLELKAEYPDAKLVVGNTEVGIEMRFKNAQYPVLISPTHVPELNAIKVKDDGLEIGAAVRLSELQNLFRKVVKERPAH 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  323 KTEVFRGVLEQLRWFAGKQVKSVASVGGNIITASPISDLNPVFMASGAKLTLVSR-GTRRTVQMDHtFFPGYRKTLLSPE 401
Cdd:PLN02906  318 ETSACKAFIEQLKWFAGTQIRNVASIGGNICTASPISDLNPLWMAAGATFVIISCdGDIRSVPASD-FFLGYRKVDLKPD 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  402 EILLSIEIPYSREGEYFSAFKQASRREDDIAKVTSGMRVLFKPGTTE--VQELALCYGGMANRTISALKTTQRQLSKLWK 479
Cdd:PLN02906  397 EILLSVFLPWTRPFEYVKEFKQAHRRDDDIAIVNAGMRVKLEEKDGEwiVSDASIAYGGVAPLSVSARKTEEFLIGKPWN 476

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  480 EELLQDVCAGLAEELHLPPDAPGGMVDFRCTLTLSFFFKFYLTVLQKL-GQENLEDKcgkLDPTFASATLLFQKDPPADV 558
Cdd:PLN02906  477 KETLQDALKVLQKDILIKEDAPGGMVEFRKSLALSFFFKFFLWVSHQLeADGSTIET---FPESHLSAAQPFPRPSSVGM 553

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  559 QLFQEVPKGQSeedmVGRPLPHLAADMQASGEAVYCDDIPRYENELSLRLVTSTRAHAKIKSIDTSEAKKVPGFVCFISA 638
Cdd:PLN02906  554 QDYETVKQGTA----VGQPEVHLSAELQVTGEAEYADDIPMPPNTLHAALVLSTKPHARILSIDDSEAKSSPGFAGIFLA 629

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  639 DDVPGSNITG-ICNDETVFAKDKVTCVGHIIGAVVADTPEHTQRAAQGVKITYEELPAIITIEDAIKNNSFY-GPELKIE 716
Cdd:PLN02906  630 KDVPGDNMIGpVVHDEELFATDVVTCVGQVIGVVVADTQENAKAAARKVKVEYEELPAILSIEEAIEAGSFHpNTERRLE 709

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  717 KGDLKKGFS--EADNVVSGEIYIGGQEHFYLETHCTIAVPKGEAGEMELFVSTQNTMKTQSFVAKMLGVPANRIVVRVKR 794
Cdd:PLN02906  710 KGDVELCFAsgQCDRIIEGEVQMGGQEHFYLEPNSSLVWTSDSGNEVHMISSTQAPQKHQKYVAHVLGLPMSKVVCKTKR 789

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  795 MGGGFGGKETRSTVVSTAVALAAYKTGRPVRCMLDRDEDMLITGGRHPFLARYKVGFMKTGTVVALEVDHFSNVGNTQDL 874
Cdd:PLN02906  790 IGGGFGGKETRSAFIAAAAAVPAYLLNRPVKLTLDRDVDMMITGQRHAFLGKYKVGFTNEGKILALDLEIYNNGGNSLDL 869

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  875 SQSIMERALFHMDNCYKIPNIRGTGRLCKTNLPSNTAFRGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKNLYKEGDLT 954
Cdd:PLN02906  870 SGAVLERAMFHSDNVYEIPNVRIVGNVCFTNFPSNTAFRGFGGPQGMLITENWIQRIAVELNKSPEEIREMNFQGEGSVT 949

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  955 HFNQKLEGFTLPRCWEECLASSQYHARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGALLHVYTDGSVLLTH 1034
Cdd:PLN02906  950 HYGQVLQHCTLPQLWDELKVSCDFLKRREEVDEFNAKNRWKKRGVAMVPTKFGISFTTKFMNQAGALVHVYTDGTVLVTH 1029

                        1050
                  ....*....|....*
gi 767915204 1035 GGTEMGQGLHTKMVQ 1049
Cdd:PLN02906 1030 GGVEMGQGLHTKVAQ 1044
mam_aldehyde_ox TIGR02969
aldehyde oxidase; Members of this family are mammalian aldehyde oxidase (EC 1.2.3.1) isozymes, ...
 5-1053 0e+00

aldehyde oxidase; Members of this family are mammalian aldehyde oxidase (EC 1.2.3.1) isozymes, closely related to xanthine dehydrogenase/oxidase.


Pssm-ID: 132014 [Multi-domain]  Cd Length: 1330  Bit Score: 1142.43  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204     5 KLVFFVNGRKVVEKNADPETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSKYDRLQNKIVHFSANACLAPICSLHHVA 84
Cdd:TIGR02969    2 ELLFYVNGRKVVEKNVDPETMLLPYLRKKLRLTGTKYGCGGGGCGACTVMISRYNPSTKSIRHHPVNACLTPICSLYGAA 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204    85 VTTVEGIGSTKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNQPEPTMEEIENAFQGNLCRCTGYRPILQGFRTFA 164
Cdd:TIGR02969   82 VTTVEGIGSTRTRLHPVQERIAKCHGTQCGFCTPGMVMSMYALLRNHPEPTLDQLTDALGGNLCRCTGYRPIIDACKTFC 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   165 RDGGCCGGDGNNPnCCMNQKKDHSVSL------SPSLFKPEEFTPLDPTQEPIFPPELLRLKDT-PRKQLRFEGERVTWI 237
Cdd:TIGR02969  162 KTSGCCQSKENGV-CCLDQGINGLPEFeegdetSPELFSEEEFLPLDPTQELIFPPELMRMAEKqPQRTRVFYSERMMWI 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   238 QASTLKELLDLKAQHPDAKLVVGNTEIGIEMKFKNMLFPMIVCPAWIPELNSVEHGPDGISFGAACPLSIVEKTLVDAVA 317
Cdd:TIGR02969  241 SPVTLKELLEAKFKYPQAPVVMGNTSVGPEVKFKGVFHPVIISPDRIEELSVVNHTGDGLTLGAGLSLAQVKDILADVVQ 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   318 KLPAQKTEVFRGVLEQLRWFAGKQVKSVASVGGNIITASPISDLNPVFMASGAKLTLVSRGTRRTVQMDHTFFPGYRKTL 397
Cdd:TIGR02969  321 KLPEETTQTYRALLKHLGTLAGSQIRNMASLGGHIISRHLDSDLNPLLAVGNCTLNLLSKEGKRQIPLSEQFLSKCPDAD 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   398 LSPEEILLSIEIPYSREGEYFSAFKQASRREDDIAKVTSGMRVLFKPGTTEVQELALCYGGMANRTISALKTTQRQLSKL 477
Cdd:TIGR02969  401 LKPQEILVSVNIPYSRKWEFVSAFRQAQRQQNALAIVNSGMRVFFGEGDGIIRELSISYGGVGPTTICAKNSCQKLIGRP 480

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   478 WKEELLQDVCAGLAEELHLPPDAPGGMVDFRCTLTLSFFFKFYLTVLQKLGQEN------LEDKcgkldptFASATLLFQ 551
Cdd:TIGR02969  481 WNEEMLDTACRLILDEVSLAGSAPGGKVEFKRTLIISFLFKFYLEVSQILKRMDpghypsLADK-------YESALEDLH 553

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   552 KDPPADVQLFQEVPKGQSEEDMVGRPLPHLAADMQASGEAVYCDDIPRYENELSLRLVTSTRAHAKIKSIDTSEAKKVPG 631
Cdd:TIGR02969  554 SKHHWSTLKHQNVDSMQLPQDPIGHPIMHLSGVKHATGEAIYCDDMPAVDQELFLTFVTSSRAHAKIVSIDLSEALSLPG 633

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   632 FVCFISADDVPGSNITGIcndETVFAKDKVTCVGHIIGAVVADTPEHTQRAAQGVKITYEEL-PAIITIEDAIKNNSFYG 710
Cdd:TIGR02969  634 VVDIITAEHLQDANTFGT---EKLLATDKVHCVGQLVCAVIADSEVQAKQAAKHVKIVYRDLePLILTIEEAIQHKSFFE 710

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   711 PELKIEKGDLKKGFSEADNVVSGEIYIGGQEHFYLETHCTIAVPKGEAGEMELFVSTQNTMKTQSFVAKMLGVPANRIVV 790
Cdd:TIGR02969  711 PERKLEYGNVDEAFKVVDQILEGEIHMGGQEHFYMETQSMLVVPKGEDQEMDVYVSTQFPKYIQDIVAATLKLPVNKVMC 790

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   791 RVKRMGGGFGGKETRSTVVSTAVALAAYKTGRPVRCMLDRDEDMLITGGRHPFLARYKVGFMKTGTVVALEVDHFSNVGN 870
Cdd:TIGR02969  791 HVRRVGGAFGGKVGKTSIMAAITAFAANKHGRAVRCTLERGEDMLITGGRHPYLGKYKAGFMNDGRIVALDVEHYSNGGS 870

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   871 TQDLSQSIMERALFHMDNCYKIPNIRGTGRLCKTNLPSNTAFRGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKNLYKE 950
Cdd:TIGR02969  871 SLDESLWVIEMGLLKMDNAYKFPNLRCRGWACRTNLPSNTAFRGFGFPQAGLITEACITEVAAKCGLSPEKVRTINMYKE 950

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   951 GDLTHFNQKLEGFTLPRCWEECLASSQYHARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGALLHVYTDGSV 1030
Cdd:TIGR02969  951 IDQTPYKQEINAKNLFQCWRECMAKSSYSERKVAVEKFNAENYWKKRGLAVIPLKFPVGLGSVAMGQAAALVHIYLDGSV 1030

                         1050      1060
                   ....*....|....*....|...
gi 767915204  1031 LLTHGGTEMGQGLHTKMVQELAR 1053
Cdd:TIGR02969 1031 LVTHGGIEMGQGVHTKMIQVVSR 1053
XdhB COG4631
Xanthine dehydrogenase, molybdopterin-binding subunit XdhB [Nucleotide transport and ...
 574-1049 0e+00

Xanthine dehydrogenase, molybdopterin-binding subunit XdhB [Nucleotide transport and metabolism];


Pssm-ID: 443669 [Multi-domain]  Cd Length: 769  Bit Score: 720.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  574 VGRPLPHLAADMQASGEAVYCDDIPRYENELSLRLVTSTRAHAKIKSIDTSEAKKVPGFVCFISADDVPGSN-ITGICND 652
Cdd:COG4631    14 VGKSLPHESARLHVTGEARYIDDLPEPAGTLHAAPGLSPVAHARILSIDLSAVRAAPGVVAVLTAADIPGENdIGPIIHD 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  653 ETVFAKDKVTCVGHIIGAVVADTPEHTQRAAQGVKITYEELPAIITIEDAIKNNSFYGPELKIEKGDLKKGFSEADNVVS 732
Cdd:COG4631    94 EPLLADGEVEYVGQPVFAVVAESREAARRAARLAKIEYEELPAILTIEEALAAGSFVLPPHTLRRGDADAALAAAPHRLE 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  733 GEIYIGGQEHFYLETHCTIAVPkGEAGEMELFVSTQNTMKTQSFVAKMLGVPANRIVVRVKRMGGGFGGKETRSTVVSTA 812
Cdd:COG4631   174 GEFEIGGQEHFYLEGQIALAIP-GEDGGMLVHSSTQHPSEVQHLVAHVLGVPMHAVTVEVRRMGGGFGGKESQAALFAAL 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  813 VALAAYKTGRPVRCMLDRDEDMLITGGRHPFLARYKVGFMKTGTVVALEVDHFSNVGNTQDLSQSIMERALFHMDNCYKI 892
Cdd:COG4631   253 AALAARKTGRPVKLRLDRDDDMVMTGKRHPFRIDYEVGFDDDGRILGLDITLAARCGWSADLSGPVADRAMFHADNAYYL 332

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  893 PNIRGTGRLCKTNLPSNTAFRGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKNLY--KEGDLTHFNQKLEGFTLPRCWE 970
Cdd:COG4631   333 PAVRITGHRCKTNTQSNTAFRGFGGPQGMLAIERVIDDIARALGLDPLDVRRRNFYgpAERNTTPYGQPVEDNILHELVD 412

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767915204  971 ECLASSQYHARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGALLHVYTDGSVLLTHGGTEMGQGLHTKMVQ 1049
Cdd:COG4631   413 ELEESSDYAARRAAIAAFNAASPVLKRGLALTPVKFGISFTATHLNQAGALVHVYTDGSVQLNHGGTEMGQGLHTKVAQ 491
xanthine_xdhB TIGR02965
xanthine dehydrogenase, molybdopterin binding subunit; Members of the protein family are the ...
 574-1053 0e+00

xanthine dehydrogenase, molybdopterin binding subunit; Members of the protein family are the molybdopterin-containing large subunit (or, in, eukaryotes, the molybdopterin-binding domain) of xanthine dehydrogenase, and enzyme that reduces the purine pool by catabolizing xanthine to urate. This model is based primarily on bacterial sequences; it does not manage to include all eukaryotic xanthine dehydrogenases and thereby discriminate them from the closely related enzyme aldehyde dehydrogenase. [Purines, pyrimidines, nucleosides, and nucleotides, Other]


Pssm-ID: 274367 [Multi-domain]  Cd Length: 758  Bit Score: 596.28  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   574 VGRPLPHLAADMQASGEAVYCDDIPRYENELSLRLVTSTRAHAKIKSIDTSEAKKVPGFVCFISADDVPGSN-ITGICND 652
Cdd:TIGR02965    1 VGTSLKHESAHKHVAGTAVYIDDIPEPAGTLHAALGLSTRAHARITSMDLSAVRAAPGVVDVLTAADIPGENdISPIIHD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   653 ETVFAKDKVTCVGHIIGAVVADTPEHTQRAAQGVKITYEELPAIITIEDAI-KNNSFYGPELKIEKGDLKKGFSEADNVV 731
Cdd:TIGR02965   81 DPLLADGKVEFVGQPIFAVVATSRDAARRAARLAKIEYEELPAVLDIEEALaAGSRLVTPPLTLERGDAAAALAAAPHRL 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   732 SGEIYIGGQEHFYLETHCTIAVPkGEAGEMELFVSTQNTMKTQSFVAKMLGVPANRIVVRVKRMGGGFGGKETRSTVVST 811
Cdd:TIGR02965  161 SGTMRIGGQEHFYLEGQIALAVP-GEDGGMHVWSSTQHPSEVQHLVAHVLGVPSHAVTVEVRRMGGGFGGKETQANLFAC 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   812 AVALAAYKTGRPVRCMLDRDEDMLITGGRHPFLARYKVGFMKTGTVVALEVDHFSNVGNTQDLSQSIMERALFHMDNCYK 891
Cdd:TIGR02965  240 LAAVAARKTGRPVKLRPDRDDDMMITGKRHDFRVDYDVGFDDEGRILGVDIDMAARCGFSADLSGPVTDRALFHADNAYF 319

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   892 IPNIRGTGRLCKTNLPSNTAFRGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKNLYKEGD--LTHFNQKLEGFTLPRCW 969
Cdd:TIGR02965  320 LPDVTITSHPLKTNTQSNTAFRGFGGPQGMVAIERIMDEVARALGKDPLEVRKRNFYGKDErnVTPYHQTVEDNIIHEII 399

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   970 EECLASSQYHARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGALLHVYTDGSVLLTHGGTEMGQGLHTKMVQ 1049
Cdd:TIGR02965  400 EELEASSDYAARRAAIRAFNATSPVLKKGIALTPVKFGISFTVTHLNQAGALVHVYTDGSIHLNHGGTEMGQGLNTKVAQ 479


                   ....
gi 767915204  1050 ELAR 1053
Cdd:TIGR02965  480 VVAE 483
PLN00192 PLN00192
aldehyde oxidase
 1-1052 0e+00

aldehyde oxidase


Pssm-ID: 215096 [Multi-domain]  Cd Length: 1344  Bit Score: 570.12  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204    1 MTADKLVFFVNGRKVVEKNADPETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSKYDRLQNKIVHFSANACLAPICSL 80
Cdd:PLN00192    1 SSNMSLVFAVNGERFELSSVDPSTTLLEFLRTQTPFKSVKLGCGEGGCGACVVLLSKYDPVLDQVEDFTVSSCLTLLCSV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   81 HHVAVTTVEGIGSTKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRN-----QPEP-------TMEEIENAFQGNLC 148
Cdd:PLN00192   81 NGCSITTSEGLGNSKDGFHPIHKRFAGFHASQCGFCTPGMCISLFSALVNadktdRPEPpsgfsklTVVEAEKAVSGNLC 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  149 RCTGYRPILQGFRTFARDGGCCGGDGnnpNCCMNQKKDHSVSLSpslfkpeEFTPLDPTQEPIFPPELLrlKDTPRKQLR 228
Cdd:PLN00192  161 RCTGYRPIVDACKSFAADVDIEDLGL---NSFWKKGESEEAKLS-------KLPPYNHSDHICTFPEFL--KKEIKSSLL 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  229 FEGERVTWIQASTLKELLDL-KAQHPDA---KLVVGNTEIGIemkFKNM-LFPMIVCPAWIPELNSVEHGPDGISFGAAC 303
Cdd:PLN00192  229 LDSSRYRWYTPVSVEELQSLlESNNFDGvsvKLVVGNTGTGY---YKDEeLYDKYIDIRHIPELSMIRRDEKGIEIGAVV 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  304 PLSIVEKTLVDAvaklpAQKTEVFRGVLEQLRWFAGKQVKSVASVGGNIITAS----PiSDLNPVFMASGAKLTLVSRGT 379
Cdd:PLN00192  306 TISKAIEALREE-----SKSEYVFKKIADHMEKIASRFVRNTGSIGGNLVMAQrkqfP-SDIATILLAAGSTVNIQNASK 379

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  380 RRTVQMDHtFFpgyRKTLLSPEEILLSIEIPYSREGE------YFSAFKQASR-REDDIAKVTSGMRVLFK----PGTTE 448
Cdd:PLN00192  380 REKLTLEE-FL---ERPPLDSKSLLLSVEIPSWTSSSgsdtklLFETYRAAPRpLGNALPYLNAAFLAEVSqdasSGGIV 455

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  449 VQELALCYGGM-ANRTISALKTTQRQLSKLWKEELLQDVCAGLAEELhlPPDAPGGMVDFRCTLTLSFFFKFyltvLQKL 527
Cdd:PLN00192  456 VNDCRLAFGAYgTKHAIRARKVEEFLTGKVLSDSVLYEAVRLLKGIV--VPEDGTSHPEYRSSLAVGFLFDF----LSPL 529

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  528 GQENLEDKCGKLDPTFASATLLFQKDPPADVQLF----QEVPKGQsEEDMVGRPLPHLAADMQASGEAVYCDDIPRYENE 603
Cdd:PLN00192  530 IESNAKSSNGWLDGGSNTKQNPDQHDDVKKPTLLlsskQQVEENN-EYHPVGEPIKKVGAALQASGEAVYVDDIPSPKNC 608

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  604 LSLRLVTSTRAHAKIKSIDTSEAKKVPGFVCFISADDVP--GSNI--TGICNDETVFAKDKVTCVGHIIGAVVADTPEHT 679
Cdd:PLN00192  609 LYGAFIYSTKPLARVKGIKFKSNLVPQGVLAVITFKDIPkgGQNIgsKTIFGPEPLFADEVTRCAGQRIALVVADTQKHA 688

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  680 QRAAQGVKITY--EEL-PAIITIEDAIKNNSFYG--PELKIEK-GDLKKGFSEADN-VVSGEIYIGGQEHFYLETHCTIA 752
Cdd:PLN00192  689 DMAANLAVVEYdtENLePPILTVEDAVKRSSLFEvpPFLYPKPvGDISKGMAEADHkILSAEIKLGSQYYFYMETQTALA 768

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  753 VPKgEAGEMELFVSTQNTMKTQSFVAKMLGVPANRIVVRVKRMGGGFGGKETRSTVVSTAVALAAYKTGRPVRCMLDRDE 832
Cdd:PLN00192  769 LPD-EDNCIVVYSSTQCPEYVHSVIARCLGIPEHNVRVITRRVGGGFGGKAVKSMPVATACALAAFKLQRPVRMYLNRKT 847

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  833 DMLITGGRHPFLARYKVGFMKTGTVVALEVDHFSNVGNTQDLSqSIMERALFHMDNCYKIPNIRGTGRLCKTNLPSNTAF 912
Cdd:PLN00192  848 DMIMAGGRHPMKITYSVGFKSDGKITALHLDILINAGISPDIS-PIMPRNIIGALKKYDWGALSFDIKVCKTNLSSRSAM 926

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  913 RGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKNLYKEGDLTHFNQKLEG----FTLPRCWEECLASSQYHARKSEVDKF 988
Cdd:PLN00192  927 RAPGEVQGSYIAEAIIEHVASTLSMDVDSVRKINLHTYESLKLFYGDSAGepseYTLPSIWDKLASSSEFKQRTEMVKEF 1006

                        1050      1060      1070      1080      1090      1100
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767915204  989 NKENCWKKRGLCIIPtkfgISFTVpFLNQAGALLHVYTDGSVLLTHGGTEMGQGLHTKmVQELA 1052
Cdd:PLN00192 1007 NRSNKWKKRGISRVP----IVHEV-MLRPTPGKVSILSDGSIAVEVGGIEIGQGLWTK-VKQMA 1064
xanthine_xdhA TIGR02963
xanthine dehydrogenase, small subunit; Members of this protein family are the small subunit ...
 6-523 8.54e-175

xanthine dehydrogenase, small subunit; Members of this protein family are the small subunit (or, in eukaryotes, the N-terminal domain) of xanthine dehydrogenase, an enzyme of purine catabolism via urate. The small subunit contains both an FAD and a 2Fe-2S cofactor. Aldehyde oxidase (retinal oxidase) appears to have arisen as a neofunctionalization among xanthine dehydrogenases in eukaryotes and [Purines, pyrimidines, nucleosides, and nucleotides, Other]


Pssm-ID: 274365 [Multi-domain]  Cd Length: 467  Bit Score: 519.14  E-value: 8.54e-175
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204     6 LVFFVNGRKVVEKNADPETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSKYDRLQnKIVHFSANACLAPICSLHHVAV 85
Cdd:TIGR02963    1 IRFFLNGETVTLSDVDPTRTLLDYLREDAGLTGTKEGCAEGDCGACTVVVGELVDGG-KLRYRSVNACIQFLPSLDGKAV 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204    86 TTVEGIGSTKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNQPEPTMEEIENAFQGNLCRCTGYRPILQGFRtfar 165
Cdd:TIGR02963   80 VTVEDLRQPDGRLHPVQQAMVECHGSQCGFCTPGFVMSLYALYKNSPAPSRADIEDALQGNLCRCTGYRPILDAAE---- 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   166 dggccggdgnnpnccmnQKKDHSVSlspslfkpeefTPLDPTQEPIFpPELLRLKDTPRKQLRFEGERVtwIQASTLKEL 245
Cdd:TIGR02963  156 -----------------AAFDYPCS-----------DPLDADRAPII-ERLRALRAGETVELNFGGERF--IAPTTLDDL 204

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   246 LDLKAQHPDAKLVVGNTEIGIEMKFKNMLFPMIVCPAWIPELNSVEHGPDGISFGAACPLSIVEKTLVDAVAKLPaqkte 325
Cdd:TIGR02963  205 AALKAAHPDARIVAGSTDVGLWVTKQMRDLPDVIYVGQVAELKRIEETDDGIEIGAAVTLTDAYAALAKRYPELG----- 279

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   326 vfrgvlEQLRWFAGKQVKSVASVGGNIITASPISDLNPVFMASGAKLTLVSRGTRRTVQMDhTFFPGYRKTLLSPEEILL 405
Cdd:TIGR02963  280 ------ELLRRFASLQIRNAGTLGGNIANGSPIGDSPPALIALGARLTLRKGEGRRTLPLE-DFFIDYGKTDRQPGEFVE 352

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   406 SIEIPYSREGEYFSAFKQASRREDDIAKVTSGMRVLFKPGTteVQELALCYGGMANRTISALKTTQRQLSKLWKEELLQD 485
Cdd:TIGR02963  353 ALHVPRPTPGERFRAYKISKRFDDDISAVCAAFNLELDGGV--VAEIRIAFGGMAATPKRAAATEAALLGKPWNEATVEA 430

                          490       500       510
                   ....*....|....*....|....*....|....*....
gi 767915204   486 VCAGLAEELH-LPPDAPGGmvDFRCTLTLSFFFKFYLTV 523
Cdd:TIGR02963  431 AMAALAGDFTpLSDMRASA--EYRLLTAKNLLRRFFLET 467
CoxL COG1529
Aldehyde, CO or xanthine dehydrogenase, Mo-binding subunit [Energy production and conversion]; ...
 574-1052 1.37e-126

Aldehyde, CO or xanthine dehydrogenase, Mo-binding subunit [Energy production and conversion]; Aldehyde, CO or xanthine dehydrogenase, Mo-binding subunit is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 441138 [Multi-domain]  Cd Length: 741  Bit Score: 403.07  E-value: 1.37e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  574 VGRPLPHLAADMQASGEAVYCDDIpRYENELSLRLVTSTRAHAKIKSIDTSEAKKVPGFVCFISADDVPGSNITGIC--N 651
Cdd:COG1529    10 IGKPVPRVDGPAKVTGRARYTDDI-RLPGMLYAAVVRSPHAHARIKSIDTSAALALPGVVAVLTGEDLPGLKFGLPGpdP 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  652 DETVFAKDKVTCVGHIIGAVVADTPEHTQRAAQGVKITYEELPAIITIEDAIK-----------NNSFYgpELKIEKGDL 720
Cdd:COG1529    89 DQPPLADDKVRYVGEPVAAVVAETREAARDAAELIKVEYEPLPAVVDPEAALApgaplvheelpGNVAA--EWRGERGDV 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  721 KKGFSEADNVVSGEIYIGGQEHFYLETHCTIAVPKGEaGEMELFVSTQNTMKTQSFVAKMLGVPANRIVVRVKRMGGGFG 800
Cdd:COG1529   167 DAAFAEADVVVEATYTTPRLAHAPMEPRAAVAEWDGD-GRLTVWASTQGPHLVRRALARALGLPPEKVRVIAPDVGGGFG 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  801 GKETrSTVVSTAVALAAYKTGRPVRCMLDRDEDMLITGGRHPFLARYKVGFMKTGTVVALEVDHFSNVGNTQDLSQSIME 880
Cdd:COG1529   246 GKLD-VYPEEVLAALAARKLGRPVKLVLTREEDFLADTHRHATVQRVRLGADKDGKITALRHDVVADTGAYASFGEAVLP 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  881 RALFHMDNCYKIPNIRGTGRLCKTNLPSNTAFRGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKNLYKEGDLTHFNQKL 960
Cdd:COG1529   325 LGATMATGPYAIPNVRVEARAVYTNTPPTGAYRGPGRPQAAFALESAMDELAEELGMDPVELRLRNLIRPGDFPPTGQPY 404

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  961 EGFTLPRCWEECLASSQYHARKSEVDKFNKEncwKKRGLciiptkfGISFTV----PFLNQAGALLHVYTDGSVLLTHGG 1036
Cdd:COG1529   405 DSGRLAECLEKAAEAFGWGERRARPAEARAG---KLRGI-------GVAAYIegsgGGGDPESARVRLNPDGSVTVYTGA 474

                         490
                  ....*....|....*.
gi 767915204 1037 TEMGQGLHTKMVQELA 1052
Cdd:COG1529   475 TDIGQGHETVLAQIAA 490
MoCoBD_1 pfam02738
Molybdopterin cofactor-binding domain;
700-947 1.57e-124

Molybdopterin cofactor-binding domain;


Pssm-ID: 460671 [Multi-domain]  Cd Length: 244  Bit Score: 379.49  E-value: 1.57e-124
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   700 EDAIKNNSFygpelKIEKGDLKKGFSEADNVVSGEIYIGGQEHFYLETHCTIAVPKGEAGEMELFVSTQNTMKTQSFVAK 779
Cdd:pfam02738    3 EEPPNNVAF-----HREKGDVEAAFAEADHVVEGEYRTGRQEHFYMETRAALAVPDDEDGRLTVYSSTQGPHLVRRLVAR 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   780 MLGVPANRIVVRVKRMGGGFGGKeTRSTVVSTAVALAAYKTGRPVRCMLDRDEDMLITGGRHPFLARYKVGFMKTGTVVA 859
Cdd:pfam02738   78 VLGIPENKVRVIVPRVGGGFGGK-TQSYPEEALAALAARKTGRPVKWVLDREEDMLATGHRHPFLIKYKVGADKDGKILA 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   860 LEVDHFSNVGNTQDLSQSIMERALFHMDNCYKIPNIRGTGRLCKTNLPSNTAFRGFGGPQGMLIAECWMSEVAVTCGMPA 939
Cdd:pfam02738  157 LDVDLYADGGAYADLSPAVPERALSHLDGPYKIPNVRVDGRAVYTNTPPNGAFRGFGRPQGMFALERLMDELAEELGMDP 236


                   ....*...
gi 767915204   940 EEVRRKNL 947
Cdd:pfam02738  237 LELRRRNL 244
XdhA COG4630
Xanthine dehydrogenase, Fe-S cluster and FAD-binding subunit XdhA [Nucleotide transport and ...
 8-493 3.38e-113

Xanthine dehydrogenase, Fe-S cluster and FAD-binding subunit XdhA [Nucleotide transport and metabolism];


Pssm-ID: 443668 [Multi-domain]  Cd Length: 476  Bit Score: 358.68  E-value: 3.38e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204    8 FFVNGRKVVEKNADPETTLLAYLRRKLGLSGTKlgcgeggcgacTVMLSkydRLQNKIVHFSA-NACLAPICSLHHVAVT 86
Cdd:COG4630     3 FLLNGELVELSDVPPTTTLLDWLREDRGLTGTKegcaegdcgacTVVVG---ELDDGGLRYRAvNACILFLPQLDGKALV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   87 TVEGIGSTKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNQPEPTMEEIENAFQGNLCRCTGYRPILQGfrtfARd 166
Cdd:COG4630    80 TVEGLAGPDGALHPVQQAMVDHHGSQCGFCTPGFVMSLFALYERGPAPDRADIEDALSGNLCRCTGYRPIIDA----AR- 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  167 ggccggdgnnpnccmnqkkdhsvslspSLFKPEEFTPLDPTQEPIfPPELLRLKDTPRKQLRFEGERvtWIQASTLKELL 246
Cdd:COG4630   155 ---------------------------AMAEAPAPDPFAADRAAV-AAALRALADGETVELGAGGSR--FLAPATLDELA 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  247 DLKAQHPDAKLVVGNTEIGIEMKfKNM-LFPMIVCPAWIPELNSVEHGPDGISFGAACPLSIVEKTLVDAVAKLPaqkte 325
Cdd:COG4630   205 ALLAAHPDARLVAGATDVGLWVT-KQLrDLPPVIFLGRVAELRRIEETDDGLEIGAAVTLSDAEAALAAHFPELA----- 278

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  326 vfrgvlEQLRWFAGKQVKSVASVGGNIITASPISDLNPVFMASGAKLTLVSRGTRRTVQMDHtFFPGYRKTLLSPEEILL 405
Cdd:COG4630   279 ------ELLRRFASRQIRNAGTLGGNIANGSPIGDSPPALIALGAELVLRSGDGRRTLPLED-FFLGYRKTDLQPGEFVE 351

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  406 SIEIPYSREGEYFSAFKQASRREDDIAKVTSGMRVLFKPGTteVQELALCYGGMANRTISALKTTQRQLSKLWKEELLQD 485
Cdd:COG4630   352 AIRIPLPAAGQRLRAYKVSKRFDDDISAVCAAFALTLDDGT--VTEARIAFGGMAATPKRARAAEAALLGQPWTEATVAA 429


                  ....*...
gi 767915204  486 VCAGLAEE 493
Cdd:COG4630   430 AAAALAQD 437
PRK09970 PRK09970
xanthine dehydrogenase subunit XdhA; Provisional
 572-1050 6.63e-68

xanthine dehydrogenase subunit XdhA; Provisional


Pssm-ID: 236637 [Multi-domain]  Cd Length: 759  Bit Score: 243.07  E-value: 6.63e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  572 DMVGRPLPHLAADMQASGEAVYCDDIPRyENELSLRLVTSTRAHAKIKSIDTSEAKKVPGFVCFISADDVP-------GS 644
Cdd:PRK09970    1 MAIGKSIMRVDAIAKVTGRAKYTDDYVM-AGMLYAKYVRSPIAHGKVKSIDTEEARSLPGVEAVFTWEDVPdipfptaGH 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  645 NITgicNDET-------VFAKDKVTCVGHIIGAVVADTPEHTQRAAQGVKITYEELPAIITIEDAIKNNSfygPEL---- 713
Cdd:PRK09970   80 PWS---LDPNhrdiadrALLTRHVRHHGDAVAAVVARDELTAEKALKLIKVEYEELPVITDPEAALAEGA---PPIhngr 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  714 -------KIEKGDLKKGFSEADNVVSGEIYIGGQEHFYLETHCTIAVpKGEAGEMELFVSTQNTMKTQSFVAKMLGVPAN 786
Cdd:PRK09970  154 gnllkqsTMSTGNVQQTIKAADYQVQGHYETPIVQHCHMENVTSYAY-MEDDGRITIVSSTQIPHIVRRVVGQALGIPWG 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  787 RIVVRVKRMGGGFGGKETrSTVVSTAVALAAYKTGRPVRCMLDRDEDMLITGGRHPFLARYKVGFMKTGTVVALEVDHFS 866
Cdd:PRK09970  233 KVRVIKPYVGGGFGNKQD-VLEEPLAAFLTSKVGGRPVKVSLSREECFLATRTRHAFTIDIKMGVNRDGTLKGYSLDVLS 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  867 NVGNTQDLSQSIMERALFHMDNCYKIPNIRGTGRLCKTNLPSNTAFRGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKN 946
Cdd:PRK09970  312 NTGAYASHGHSIASAGGNKVAYLYPRCAYKYSSKTVYTNLPSAGAMRGYGAPQVVFAVESMLDDAATALGIDPVEFRLRN 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  947 LYKEGDLTHFNQK-LEGFTLPRCWEECLASSQYHARKSEVDkfnKENCWKKRGLCIIPTKFGiSFTVPF-LNQAGALLHV 1024
Cdd:PRK09970  392 AAREGDANPLSGKrIYSAGLPECLEKGRKIFEWDKRRAECK---NQQGNLRRGVGVACFSYT-SGTWPVgLEIAGARLLM 467

                         490       500
                  ....*....|....*....|....*....
gi 767915204 1025 YTDGSVLLTHGGTEMGQGLHT---KMVQE 1050
Cdd:PRK09970  468 NQDGTVQVQSGATEIGQGSDTvfsQMVAE 496
FAD_binding_5 pfam00941
FAD binding domain in molybdopterin dehydrogenase;
233-412 7.55e-60

FAD binding domain in molybdopterin dehydrogenase;


Pssm-ID: 460007 [Multi-domain]  Cd Length: 170  Bit Score: 202.00  E-value: 7.55e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   233 RVTWIQASTLKELLDLKAQHPDAKLVVGNTEIGIEMKFKNMLFPMIVCPAWIPELNSVEHGPDGISFGAACPLS-IVEKT 311
Cdd:pfam00941    2 KFGYYRPASLAEALELLAAGPDAKLVAGGTSLGPLMKLRLARPDHLIDINGIPELRGIEETDGGLEIGAAVTLSeIAEPL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   312 LVDAVAKLPaqktevfrgvlEQLRWFAGKQVKSVASVGGNIITASPISDLNPVFMASGAKLTLVSRGTRRTVQMDHtFFP 391
Cdd:pfam00941   82 LREAYPALS-----------EALRKIASPQIRNVGTIGGNIANASPISDLPPALLALDAKVELRSGEGERTVPLED-FFL 149

                          170       180
                   ....*....|....*....|.
gi 767915204   392 GYRKTLLSPEEILLSIEIPYS 412
Cdd:pfam00941  150 GYGKTALEPGELITAVIIPLP 170
Ald_Xan_dh_C pfam01315
Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain;
588-694 1.04e-44

Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain;


Pssm-ID: 426197 [Multi-domain]  Cd Length: 107  Bit Score: 156.62  E-value: 1.04e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   588 SGEAVYCDDIPRYENELsLRLVTSTRAHAKIKSIDTSEAKKVPGFVCFISADDVPGSNITGICND-ETVFAKDKVTCVGH 666
Cdd:pfam01315    1 TGEAVYVDDIPAPGNLY-GAFVRSTIAHAKIVSIDTSAALALPGVVAVITAKDLPGGNYNIGPIPlDPLFATDKVRHVGQ 79

                           90       100
                   ....*....|....*....|....*...
gi 767915204   667 IIGAVVADTPEHTQRAAQGVKITYEELP 694
Cdd:pfam01315   80 PIAAVVADDEETARRAAKLVKVEYEELP 107
Ald_Xan_dh_C smart01008
Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Aldehyde oxidase catalyses ...
 588-694 1.40e-41

Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Aldehyde oxidase catalyses the conversion of an aldehyde in the presence of oxygen and water to an acid and hydrogen peroxide. The enzyme is a homodimer, and requires FAD, molybdenum and two 2FE-2S clusters as cofactors. Xanthine dehydrogenase catalyses the hydrogenation of xanthine to urate, and also requires FAD, molybdenum and two 2FE-2S clusters as cofactors. This activity is often found in a bifunctional enzyme with xanthine oxidase activity too. The enzyme can be converted from the dehydrogenase form to the oxidase form irreversibly by proteolysis or reversibly through oxidation of sulphydryl groups.


Pssm-ID: 214971 [Multi-domain]  Cd Length: 107  Bit Score: 147.66  E-value: 1.40e-41
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204    588 SGEAVYCDDIpRYENELSLRLVTSTRAHAKIKSIDTSEAKKVPGFVCFISADDVPGSNITG-ICNDETVFAKDKVTCVGH 666
Cdd:smart01008    1 TGEARYGDDI-RLPGMLHAAVVRSPVAHARIKSIDTSAARAMPGVVAVLTAKDVPGLNDFGpLGPDEPVLADDKVRYVGQ 79

                            90       100
                    ....*....|....*....|....*...
gi 767915204    667 IIGAVVADTPEHTQRAAQGVKITYEELP 694
Cdd:smart01008   80 PVAAVVAETEEAARDAAEAVKVEYEELP 107
CutS COG2080
Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family [Energy production and ...
 8-165 9.09e-38

Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family [Energy production and conversion]; Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 441683 [Multi-domain]  Cd Length: 155  Bit Score: 138.69  E-value: 9.09e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204    8 FFVNGRKVvEKNADPETTLLAYLRRKLGLSGTKlgcgeggcgactvmlskydrlqnK----------IVHF---SANACL 74
Cdd:COG2080     6 LTVNGKPV-EVDVDPDTPLLDVLRDDLGLTGTK-----------------------FgcghgqcgacTVLVdgkAVRSCL 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   75 APICSLHHVAVTTVEGIGSTKtRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNQPEPTMEEIENAFQGNLCRCTGYR 154
Cdd:COG2080    62 TLAVQADGKEITTIEGLAEDG-ELHPLQQAFIEHGALQCGYCTPGMIMAAVALLDENPNPTEEEIREALSGNLCRCTGYV 140

                         170
                  ....*....|.
gi 767915204  155 PILQGFRTFAR 165
Cdd:COG2080   141 RIVRAVKRAAA 151
PRK09800 PRK09800
putative hypoxanthine oxidase; Provisional
 552-1045 1.92e-35

putative hypoxanthine oxidase; Provisional


Pssm-ID: 182084 [Multi-domain]  Cd Length: 956  Bit Score: 146.13  E-value: 1.92e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  552 KDPPADVQLfqeVPKGQSEEDMVGRPLPHLAADMQASGEAVYCDD-IPryENELSLRLVTSTRAHAKIKSIDTSEAKKVP 630
Cdd:PRK09800  153 NNPQATIDI---APTFRDDLEVIGKHYPKTDAAKMVQAKPCYVEDrVT--ADACVIKMLRSPHAHALITHLDVSKAEALP 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  631 GFVCFISADDVPGSNITGICN--------DETVFAKdKVTCVGHIIGAVVADTPEHTQRAAQGVKITYEELPAIITIEDA 702
Cdd:PRK09800  228 GVVHVITHLNCPDIYYTPGGQsapepsplDRRMFGK-KMRHVGDRVAAVVAESEEIALEALKLIDVEYEVLKPVMSIDEA 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  703 IKNNS--------FYG------------------------------PELKIEK------GDLKKGFSEADNVVSGEIYIG 738
Cdd:PRK09800  307 MAEDApvvhdepvVYVagapdtleddnshaaqrgehmiinfpigsrPRKNIAAsihghiGDMDKGFADADVIIERTYNST 386

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  739 GQEHFYLETHCTIAVPKGEagEMELFVSTQNTMKTQSFVAKMLGVPANRIVVRVKRMGGGFGGKEtrSTVVSTAVALAAY 818
Cdd:PRK09800  387 QAQQCPTETHICFTRMDGD--RLVIHASTQVPWHLRRQVARLVGMKQHKVHVIKERVGGGFGSKQ--DILLEEVCAWATC 462

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  819 KTGRPVRCMLDRDEDMLITGGRHPFLARYKVGFMKTGTVVALEVDHFSNVGNTQDLSQSIMERALFHMDNCYKIPNIRGT 898
Cdd:PRK09800  463 VTGRPVLFRYTREEEFIANTSRHVAKVTVKLGAKKDGRLTAVKMDFRANTGPYGNHSLTVPCNGPALSLPLYPCDNVDFQ 542

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  899 GRLCKTNLPSNTAFRGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKNLYKEGD----LTHFNQKLEGFTLPRCWEECLA 974
Cdd:PRK09800  543 VTTYYSNICPNGAYQGYGAPKGNFAITMALAELAEQLQIDQLEIIERNRVHEGQelkiLGAIGEGKAPTSVPSAASCALE 622

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767915204  975 SSQYHARKS-EVDKFNKENC-WK-KRGLCIIPTKFGIsftvPFLNQAGALLHVYTDGSVLLTHGGTEMGQGLHT 1045
Cdd:PRK09800  623 EILRQGREMiQWSSPKPQNGdWHiGRGVAIIMQKSGI----PDIDQANCMIKLESDGTFIVHSGGADIGTGLDT 692
CutB COG1319
Aldehyde, CO, or xanthine dehydrogenase, FAD-binding subunit [Energy production and conversion] ...
 235-511 4.39e-35

Aldehyde, CO, or xanthine dehydrogenase, FAD-binding subunit [Energy production and conversion]; Aldehyde, CO, or xanthine dehydrogenase, FAD-binding subunit is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 440930 [Multi-domain]  Cd Length: 285  Bit Score: 135.64  E-value: 4.39e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  235 TWIQASTLKELLDLKAQH-PDAKLVVGNTEIGIEMKFKNMLFPMIVCPAWIPELNSVEHGPDGISFGAACPLS-IVEKTL 312
Cdd:COG1319     5 EYHRPTSLEEALALLAEHgPDARVLAGGTDLLPLMKLRLARPEHLVDINRIPELRGIEEEGGGLRIGALVTHAeLAASPL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  313 VDavaklpaqktEVFRGVLEQLRWFAGKQVKSVASVGGNIITASPISDLNPVFMASGAKLTLVSRGTRRTVQMDHtFFPG 392
Cdd:COG1319    85 VR----------ERYPLLAEAARAIASPQIRNRGTIGGNLANADPAADLPPALLALDATVELAGPDGERTIPAAD-FFLG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  393 YRKTLLSPEEILLSIEIPYSREGEYFSAFKQASRREDDIAKVTSGMRVLFKPGTteVQELALCYGGMANRTISALKTTQR 472
Cdd:COG1319   154 PGETALEPGELITAVRLPAPPAGAGSAYLKVGRRASDAIALVSVAVALRLDGGT--IRDARIALGGVAPTPWRAREAEAA 231

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 767915204  473 QLSKLWKEELLQDVCAGLAEELHlPPDAPGGMVDFRCTL 511
Cdd:COG1319   232 LAGKPLSEEAIEAAAEAAAAAAD-PIDDVRASAEYRRHL 269
Fer2_2 pfam01799
[2Fe-2S] binding domain;
87-158 2.58e-34

[2Fe-2S] binding domain;


Pssm-ID: 460336 [Multi-domain]  Cd Length: 73  Bit Score: 125.62  E-value: 2.58e-34
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767915204    87 TVEGIGSTKTrlHPVQERIAKSHGSQCGFCTPGIVMSMYTLL-RNQPEPTMEEIENAFQGNLCRCTGYRPILQ 158
Cdd:pfam01799    1 TIEGLAESGG--EPVQQAFAEAGAVQCGYCTPGMIMSAYALLeRNPPPPTEAEIREALSGNLCRCTGYRRIVD 71
glyceraldDH_gamma NF041020
glyceraldehyde dehydrogenase subunit gamma;
10-165 8.20e-29

glyceraldehyde dehydrogenase subunit gamma;


Pssm-ID: 468949 [Multi-domain]  Cd Length: 162  Bit Score: 113.35  E-value: 8.20e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   10 VNGrKVVEKNADPETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSKYdrlqnkivhfSANACLAPICSLHHVAVTTVE 89
Cdd:NF041020   15 VNG-VWYEAEVEPRKLLVHFLRDDLGFTGTHVGCDTSTCGACTVIMNGK----------SVKSCTVLAVQADGAEITTIE 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767915204   90 GIGStKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNQPEPTMEEIENAFQGNLCRCTGYRPILQGFRTFAR 165
Cdd:NF041020   84 GLSK-DGKLHPIQEAFWENHALQCGYCTPGMIMQAYFLLKENPNPTEEEIRDGIHGNLCRCTGYQNIVKAVKEASQ 158
CO_deh_flav_C pfam03450
CO dehydrogenase flavoprotein C-terminal domain;
419-523 1.04e-25

CO dehydrogenase flavoprotein C-terminal domain;


Pssm-ID: 460921 [Multi-domain]  Cd Length: 102  Bit Score: 102.25  E-value: 1.04e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   419 SAFKQASRREDDIAKVTSGMRVLFKPGTteVQELALCYGGMANRTISALKTTQRQLSKLWKEELLQDVCAGLAEELHlPP 498
Cdd:pfam03450    1 AAYKQAKRRDDDIAIVNAAFRVRLDGGT--VEDARIAFGGVAPTPIRATEAEAALIGKPWDEETLEAAAALLLEDLS-PL 77

                           90       100
                   ....*....|....*....|....*
gi 767915204   499 DAPGGMVDFRCTLTLSFFFKFYLTV 523
Cdd:pfam03450   78 SDPRGSAEYRRHLARSLLFRFLLEA 102
MoCoBD_2 pfam20256
Molybdopterin cofactor-binding domain;
971-1049 1.25e-25

Molybdopterin cofactor-binding domain;


Pssm-ID: 466407 [Multi-domain]  Cd Length: 282  Bit Score: 108.01  E-value: 1.25e-25
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767915204   971 ECLASSQYHARKSEVDKFNKENcwKKRGLCIIPTKFGISFTVPFLNQAGALLHVYTDGSVLLTHGGTEMGQGLHTKMVQ 1049
Cdd:pfam20256    1 KALELSDYDERRAEQAEFNRGN--RKRGIGIAPYVEGSGLGPGALNQAGALVRLNPDGSVTVYTGGTEMGQGLETKLAQ 77
4hydroxCoAred TIGR03193
4-hydroxybenzoyl-CoA reductase, gamma subunit; 4-hydroxybenzoyl-CoA reductase converts ...
 10-164 3.74e-25

4-hydroxybenzoyl-CoA reductase, gamma subunit; 4-hydroxybenzoyl-CoA reductase converts 4-hydroxybenzoyl-CoA to benzoyl-CoA, a common intermediate in the degradation of aromatic compounds. This protein family represents the gamma chain of this three-subunit enzyme.


Pssm-ID: 132237 [Multi-domain]  Cd Length: 148  Bit Score: 102.26  E-value: 3.74e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204    10 VNGRKVVEKNADpETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSKYDRLqnkivhfsANACLAPICSLHHVAvtTVE 89
Cdd:TIGR03193    6 VNGRWREDAVAD-NMLLVDYLRDTVGLTGTKQGCDGGECGACTVLVDGRPRL--------ACSTLAHRVAGRKVE--TVE 74

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767915204    90 GIgSTKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNQPEPTMEEIENAFQGNLCRCTGYRPILQGFRTFA 164
Cdd:TIGR03193   75 GL-ATNGRLSRLQQAFHERLGTQCGFCTPGMIMAAEALLRRNPSPSRDEIRAALAGNLCRCTGYVKIIESVEAAA 148
pucE TIGR03198
xanthine dehydrogenase E subunit; This gene has been characterized in B. subtilis as the ...
 6-165 1.89e-23

xanthine dehydrogenase E subunit; This gene has been characterized in B. subtilis as the Iron-sulfur cluster binding-subunit of xanthine dehydrogenase (pucE), acting in conjunction with pucC, the FAD-binding subunit and pucD, the molybdopterin binding subunit. The more common XDH complex (GenProp0640) includes the xdhA gene as the Fe-S cluster binding component.


Pssm-ID: 132242 [Multi-domain]  Cd Length: 151  Bit Score: 97.61  E-value: 1.89e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204     6 LVFFVNGRKVvEKNADPETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSkydrlqNKIvhfsANACLAPICSLHHVAV 85
Cdd:TIGR03198    4 FRFTVNGQAW-EVAAVPTTRLSDLLRKELQLTGTKVSCGIGRCGACSVLID------GKL----ANACLTMAYQADGHEI 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204    86 TTVEGIgsTKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNQPEPTMEEIENAFQGNLCRCTGYRPILQGFRTFAR 165
Cdd:TIGR03198   73 TTIEGI--AENELDPCQTAFLEEGGFQCGYCTPGMVVALKALFRETPQPSDEDMEEGLSGNLCRCTGYGGIIRSACRIRR 150
CO_deh_flav_C smart01092
CO dehydrogenase flavoprotein C-terminal domain;
420-523 1.99e-22

CO dehydrogenase flavoprotein C-terminal domain;


Pssm-ID: 215021 [Multi-domain]  Cd Length: 102  Bit Score: 92.68  E-value: 1.99e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204    420 AFKQASRREDDIAKVTSGMRVLFKPGTteVQELALCYGGMANRTISALKTTQRQLSKLWKEELLQDVCAGLAEELHLPPD 499
Cdd:smart01092    1 AYKKSRRRDGDIALVSAAVALTLDGGR--VTEARIALGGVAPTPKRAAEAEAALVGKPLTDEALARAAAAALAQDFTPLS 78

                            90       100
                    ....*....|....*....|....
gi 767915204    500 APGGMVDFRCTLTLSFFFKFYLTV 523
Cdd:smart01092   79 DMRASAEYRRQLAANLLRRALLEA 102
Se_dep_XDH TIGR03311
selenium-dependent xanthine dehydrogenase; Members of this protein resemble conventional ...
 8-165 4.80e-21

selenium-dependent xanthine dehydrogenase; Members of this protein resemble conventional xanthine dehydrogenase enzymes, which depend on molybdenum cofactor - molybdopterin bound to molybdate with two sulfur atoms as ligands. But all members of this family occur in species that contain markers for the biosynthesis of enzymes with a selenium-containing form of molybdenum cofactor. The member of this family from Enterococcus faecalis has been shown to act as a xanthine dehydrogenenase, and its activity if dependent on SelD (selenophosphate synthase), selenium, and molybdenum. [Purines, pyrimidines, nucleosides, and nucleotides, Other]


Pssm-ID: 132354 [Multi-domain]  Cd Length: 848  Bit Score: 99.53  E-value: 4.80e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204     8 FFVNGRKVVeknADPETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSKYdrlqnkivhfSANACLAPICSLHHVAVTT 87
Cdd:TIGR03311    3 FIVNGREVD---VNEEKKLLEFLREDLRLTGVKNGCGEGACGACTVIVNGK----------AVRACRFTTAKLAGKEITT 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204    88 VEGigstktrLHPVQERI-----AKSHGSQCGFCTPGIVMSMYTLLRNQPEPTMEEIENAFQGNLCRCTGYRPILQGFRT 162
Cdd:TIGR03311   70 VEG-------LTEREKDVyawafAKAGAVQCGFCIPGMVISAKALLDKNPNPTEAEIKKALKGNICRCTGYVKIIKAVRL 142


                   ...
gi 767915204   163 FAR 165
Cdd:TIGR03311  143 AAK 145
PRK09971 PRK09971
xanthine dehydrogenase subunit XdhB; Provisional
 238-457 6.09e-20

xanthine dehydrogenase subunit XdhB; Provisional


Pssm-ID: 182175 [Multi-domain]  Cd Length: 291  Bit Score: 91.64  E-value: 6.09e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  238 QASTLKELLDLKAQHPDAKLVVGNTEIGIEMKFKNMLFPMIVCPAWIPELNSVEHGPDG-ISFGAACPLS------IVEK 310
Cdd:PRK09971    9 EAATLEEAIELLADNPQAKLIAGGTDVLIQLHHHNDRYRHLVSIHNIAELRGITLAEDGsIRIGAATTFTqiiedpIIQK 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204  311 ---TLVDAVAKLpaqktevfrgvleqlrwfAGKQVKSVASVGGNIITASPISDLNPVFMASGAKLTLVSRGTRRTVQMdH 387
Cdd:PRK09971   89 hlpALAEAAVSI------------------GGPQIRNVATIGGNICNGATSADSAPPLFALDAKLEIHSPNGVRFVPI-N 149

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767915204  388 TFFPGYRKTLLSPEEILLSIEI-PYSREGEYFSAFKQASRREDDIAkvTSGMRVLFKPGTTEVQELALCYG 457
Cdd:PRK09971  150 GFYTGPGKVSLEHDEILVAFIIpPEPYEHAGGAYIKYAMRDAMDIA--TIGCAVLCRLDNGNFEDLRLAFG 218
PRK11433 PRK11433
aldehyde oxidoreductase 2Fe-2S subunit; Provisional
 5-158 2.18e-17

aldehyde oxidoreductase 2Fe-2S subunit; Provisional


Pssm-ID: 236910 [Multi-domain]  Cd Length: 217  Bit Score: 82.13  E-value: 2.18e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204    5 KLVFFVNGrKVVEKNADPETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSKyDRLqnkivhfsaNACLApICSLHH-V 83
Cdd:PRK11433   51 PVTLKVNG-KTEQLEVDTRTTLLDALREHLHLTGTKKGCDHGQCGACTVLVNG-RRL---------NACLT-LAVMHQgA 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   84 AVTTVEGIGsTKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRN---------------QPEPTMEEIENAFQGNLC 148
Cdd:PRK11433  119 EITTIEGLG-SPDNLHPMQAAFVKHDGFQCGYCTPGQICSSVAVLKEikdgipshvtvdltaAPELTADEIRERMSGNIC 197

                         170
                  ....*....|
gi 767915204  149 RCTGYRPILQ 158
Cdd:PRK11433  198 RCGAYSNILE 207
PRK09908 PRK09908
xanthine dehydrogenase iron sulfur-binding subunit XdhC;
85-158 3.74e-15

xanthine dehydrogenase iron sulfur-binding subunit XdhC;


Pssm-ID: 182139 [Multi-domain]  Cd Length: 159  Bit Score: 74.18  E-value: 3.74e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767915204   85 VTTVEGIGSTKtRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLL---RNQPEpTMEEIENAFQGNLCRCTGYRPILQ 158
Cdd:PRK09908   76 IRTLEGEAKGG-KLSHVQQAYAKSGAVQCGFCTPGLIMATTAMLakpREKPL-TITEIRRGLAGNLCRCTGYQMIVN 150
PRK09800 PRK09800
putative hypoxanthine oxidase; Provisional
 70-158 8.18e-04

putative hypoxanthine oxidase; Provisional


Pssm-ID: 182084 [Multi-domain]  Cd Length: 956  Bit Score: 43.67  E-value: 8.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915204   70 ANACLAPICSLHHVAVTTVEGIGSTKtRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNQPEPTMEEIENAFQGNLCR 149
Cdd:PRK09800   56 VNASLLIAAQLEKADIRTAESLGKWN-ELSLVQQAMVDVGVVQSGYNDPAAALIITDLLDRIAAPTREEIDDALSGLFSR 134


                  ....*....
gi 767915204  150 CTGYRPILQ 158
Cdd:PRK09800  135 DAGWQQYYQ 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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