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Conserved domains on  [gi|767915272|ref|XP_011531421|]
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THUMP domain-containing protein 2 isoform X2 [Homo sapiens]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 106779)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AdoMet_MTases super family cl17173
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 66-211 8.26e-30

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


The actual alignment was detected with superfamily member pfam01170:

Pssm-ID: 473071 [Multi-domain]  Cd Length: 184  Bit Score: 111.29  E-value: 8.26e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272   66 RAYIKTAGLRSTIAWAMASLADIKAGAFVLDPMCGLGTILLEAAKEWPDVY-----------YVGADVSDSQLLGTWDNL 134
Cdd:pfam01170   4 RPFNGPAPLKETLAAAMVNLAGWKPGDPLLDPMCGSGTILIEAALMGANIApgkfdarvrapLYGSDIDRRMVQGARLNA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272  135 KAAGLEDKIELLKISVIELPLPSESVDIIISDIPFGKKFKLGKDI----KSILQEMERVLHVGGTIVLLLSEdhHRRLTD 210
Cdd:pfam01170  84 ENAGVGDLIEFVQADAADLPLLEGSVDVIVTNPPYGIRLGSKGALealyPEFLREAKRVLRGGGWLVLLTAE--NKDFEK 161


                  .
gi 767915272  211 C 211
Cdd:pfam01170 162 A 162
 
Name Accession Description Interval E-value
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 66-211 8.26e-30

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 111.29  E-value: 8.26e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272   66 RAYIKTAGLRSTIAWAMASLADIKAGAFVLDPMCGLGTILLEAAKEWPDVY-----------YVGADVSDSQLLGTWDNL 134
Cdd:pfam01170   4 RPFNGPAPLKETLAAAMVNLAGWKPGDPLLDPMCGSGTILIEAALMGANIApgkfdarvrapLYGSDIDRRMVQGARLNA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272  135 KAAGLEDKIELLKISVIELPLPSESVDIIISDIPFGKKFKLGKDI----KSILQEMERVLHVGGTIVLLLSEdhHRRLTD 210
Cdd:pfam01170  84 ENAGVGDLIEFVQADAADLPLLEGSVDVIVTNPPYGIRLGSKGALealyPEFLREAKRVLRGGGWLVLLTAE--NKDFEK 161


                  .
gi 767915272  211 C 211
Cdd:pfam01170 162 A 162
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 78-210 5.27e-26

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 100.79  E-value: 5.27e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272  78 IAWAMASLADIKAGAFVLDPMCGLGTILLEAAKEWPDVYyvGADVSDSQLLGTWDNLKAAGLEDkIELLKISVIELPLPS 157
Cdd:COG1041   14 LARALVNLAGAKEGDTVLDPFCGTGTILIEAGLLGRRVI--GSDIDPKMVEGARENLEHYGYED-ADVIRGDARDLPLAD 90

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767915272 158 ESVDIIISDIPFGKKFKLGKD-----IKSILQEMERVLHVGGTIVLLLSEDHHRRLTD 210
Cdd:COG1041   91 ESVDAIVTDPPYGRSSKISGEellelYEKALEEAARVLKPGGRVVIVTPRDIDELLEE 148
Trm14_Arch NF040721
tRNA (guanine(6)-N2)-methyltransferase;
66-203 2.29e-16

tRNA (guanine(6)-N2)-methyltransferase;


Pssm-ID: 468685 [Multi-domain]  Cd Length: 370  Bit Score: 78.18  E-value: 2.29e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272  66 RAYIKTAGLRSTIAWAMASLADIKAGAFVLDPMCGLGTILLEAA---------------------------KEWPDVYY- 117
Cdd:NF040721 167 RVYQHPAHLNPTIASSLIYLSGWKDEESLLDPMCGSGTILIEAAlikrnippgkfredfafkkifghelleKIKKDVELk 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272 118 -VGADVSDSQLLGTWDNLKAAGLEDKIELLKISVIELPLPSESVDIIISDIPFG----KKFKLGKDIKSILQEMERVLHV 192
Cdd:NF040721 247 iYGIEKFRKHLEGAKKNAENAGVDDTIKFIQGDATKLDKYFDSVDVIVTNPPYGlrigKKRIIKKLYNNFLRSAKKILHK 326

                        170
                 ....*....|.
gi 767915272 193 GGTIVLLLSED 203
Cdd:NF040721 327 RSRIVVITAEK 337
TIGR01177 TIGR01177
putative methyltransferase, TIGR01177 family; This family of probable methyltransferases is ...
 66-197 2.88e-16

putative methyltransferase, TIGR01177 family; This family of probable methyltransferases is found exclusively in the Archaea. [Hypothetical proteins, Conserved]


Pssm-ID: 273486 [Multi-domain]  Cd Length: 329  Bit Score: 77.48  E-value: 2.88e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272   66 RAYIKTAGLRSTIAWAMASLADIKAGAFVLDPMCGLGTILLEAAKEWPDVYyvGADVSDSQLLGTWDNLKAAGLEDkIEL 145
Cdd:TIGR01177 158 RPFFKPGSMDPKLARAMVNLARVTEGDRVLDPFCGTGGFLIEAGLMGAKVI--GCDIDWKMVAGARINLEHYGIED-FFV 234

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767915272  146 LKISVIELPLPSESVDIIISDIPFGKKFKLGKD-----IKSILQEMERVLHVGGTIV 197
Cdd:TIGR01177 235 KRGDATKLPLSSESVDAIATDPPYGRSTTAAGDgleslYERSLEEFHEVLKSEGWIV 291
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 94-198 9.85e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 55.13  E-value: 9.85e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272  94 VLDPMCGLGTILLEAAkEWPDVYYVGADVSDSQLlGTWDNLKAAGLEDKIELLKISVIELPL-PSESVDIIISDIPFgkk 172
Cdd:cd02440    2 VLDLGCGTGALALALA-SGPGARVTGVDISPVAL-ELARKAAAALLADNVEVLKGDAEELPPeADESFDVIISDPPL--- 76

                         90       100
                 ....*....|....*....|....*.
gi 767915272 173 FKLGKDIKSILQEMERVLHVGGTIVL 198
Cdd:cd02440   77 HHLVEDLARFLEEARRLLKPGGVLVL 102
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 75-199 4.27e-09

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 55.93  E-value: 4.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272  75 RSTIAWAmaslaDIKAGAFVLDPMCGLGTILLEAAKEWPDV-YYVGADVSDSQLLGTWDNLKAAGLEDKIELLKISVIEL 153
Cdd:PRK00216  41 RKTIKWL-----GVRPGDKVLDLACGTGDLAIALAKAVGKTgEVVGLDFSEGMLAVGREKLRDLGLSGNVEFVQGDAEAL 115

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 767915272 154 PLPSESVDII-ISdipFGkkfkLG--KDIKSILQEMERVLHVGGTIVLL 199
Cdd:PRK00216 116 PFPDNSFDAVtIA---FG----LRnvPDIDKALREMYRVLKPGGRLVIL 157
 
Name Accession Description Interval E-value
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 66-211 8.26e-30

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 111.29  E-value: 8.26e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272   66 RAYIKTAGLRSTIAWAMASLADIKAGAFVLDPMCGLGTILLEAAKEWPDVY-----------YVGADVSDSQLLGTWDNL 134
Cdd:pfam01170   4 RPFNGPAPLKETLAAAMVNLAGWKPGDPLLDPMCGSGTILIEAALMGANIApgkfdarvrapLYGSDIDRRMVQGARLNA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272  135 KAAGLEDKIELLKISVIELPLPSESVDIIISDIPFGKKFKLGKDI----KSILQEMERVLHVGGTIVLLLSEdhHRRLTD 210
Cdd:pfam01170  84 ENAGVGDLIEFVQADAADLPLLEGSVDVIVTNPPYGIRLGSKGALealyPEFLREAKRVLRGGGWLVLLTAE--NKDFEK 161


                  .
gi 767915272  211 C 211
Cdd:pfam01170 162 A 162
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 78-210 5.27e-26

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 100.79  E-value: 5.27e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272  78 IAWAMASLADIKAGAFVLDPMCGLGTILLEAAKEWPDVYyvGADVSDSQLLGTWDNLKAAGLEDkIELLKISVIELPLPS 157
Cdd:COG1041   14 LARALVNLAGAKEGDTVLDPFCGTGTILIEAGLLGRRVI--GSDIDPKMVEGARENLEHYGYED-ADVIRGDARDLPLAD 90

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767915272 158 ESVDIIISDIPFGKKFKLGKD-----IKSILQEMERVLHVGGTIVLLLSEDHHRRLTD 210
Cdd:COG1041   91 ESVDAIVTDPPYGRSSKISGEellelYEKALEEAARVLKPGGRVVIVTPRDIDELLEE 148
Trm14_Arch NF040721
tRNA (guanine(6)-N2)-methyltransferase;
66-203 2.29e-16

tRNA (guanine(6)-N2)-methyltransferase;


Pssm-ID: 468685 [Multi-domain]  Cd Length: 370  Bit Score: 78.18  E-value: 2.29e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272  66 RAYIKTAGLRSTIAWAMASLADIKAGAFVLDPMCGLGTILLEAA---------------------------KEWPDVYY- 117
Cdd:NF040721 167 RVYQHPAHLNPTIASSLIYLSGWKDEESLLDPMCGSGTILIEAAlikrnippgkfredfafkkifghelleKIKKDVELk 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272 118 -VGADVSDSQLLGTWDNLKAAGLEDKIELLKISVIELPLPSESVDIIISDIPFG----KKFKLGKDIKSILQEMERVLHV 192
Cdd:NF040721 247 iYGIEKFRKHLEGAKKNAENAGVDDTIKFIQGDATKLDKYFDSVDVIVTNPPYGlrigKKRIIKKLYNNFLRSAKKILHK 326

                        170
                 ....*....|.
gi 767915272 193 GGTIVLLLSED 203
Cdd:NF040721 327 RSRIVVITAEK 337
TIGR01177 TIGR01177
putative methyltransferase, TIGR01177 family; This family of probable methyltransferases is ...
 66-197 2.88e-16

putative methyltransferase, TIGR01177 family; This family of probable methyltransferases is found exclusively in the Archaea. [Hypothetical proteins, Conserved]


Pssm-ID: 273486 [Multi-domain]  Cd Length: 329  Bit Score: 77.48  E-value: 2.88e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272   66 RAYIKTAGLRSTIAWAMASLADIKAGAFVLDPMCGLGTILLEAAKEWPDVYyvGADVSDSQLLGTWDNLKAAGLEDkIEL 145
Cdd:TIGR01177 158 RPFFKPGSMDPKLARAMVNLARVTEGDRVLDPFCGTGGFLIEAGLMGAKVI--GCDIDWKMVAGARINLEHYGIED-FFV 234

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767915272  146 LKISVIELPLPSESVDIIISDIPFGKKFKLGKD-----IKSILQEMERVLHVGGTIV 197
Cdd:TIGR01177 235 KRGDATKLPLSSESVDAIATDPPYGRSTTAAGDgleslYERSLEEFHEVLKSEGWIV 291
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 81-210 8.28e-12

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 61.55  E-value: 8.28e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272  81 AMASLADIKAGAFVLDPMCGLGTILLEAAKEwpDVYYVGADVSDSQLLGTWDNLKAAGLedKIELLKISVIELPLPSESV 160
Cdd:COG2226   13 ALLAALGLRPGARVLDLGCGTGRLALALAER--GARVTGVDISPEMLELARERAAEAGL--NVEFVVGDAEDLPFPDGSF 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767915272 161 DIIIS-----DIPfgkkfklgkDIKSILQEMERVLHVGGTIVLL-LSEDHHRRLTD 210
Cdd:COG2226   89 DLVISsfvlhHLP---------DPERALAEIARVLKPGGRLVVVdFSPPDLAELEE 135
RlmL COG0116
23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA ...
 66-190 1.32e-11

23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA G2445 N2-methylase RlmL is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 439886 [Multi-domain]  Cd Length: 369  Bit Score: 64.35  E-value: 1.32e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272  66 RAYIKTAGLRSTIAWAMASLADIKAGAFVLDPMCGLGTILLEAA----------------KEWPD--------------- 114
Cdd:COG0116  164 REAQGEAPLKETLAAALLLLSGWDGDRPLVDPMCGSGTILIEAAliaaniapglnrdfafEKWPDfdaelwqelreeaea 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272 115 -------VYYVGADVSDSQLLGTWDNLKAAGLEDKIELLKISVIELPLPSESvDIIISDIPFGKKFKLGKDIKSILQEME 187
Cdd:COG0116  244 rikrdppLPIFGSDIDPRAIEAARENAERAGVADLIEFEQADFRDLEPPAEP-GLIITNPPYGERLGEEEELEALYRELG 322


                 ...
gi 767915272 188 RVL 190
Cdd:COG0116  323 DVL 325
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 94-198 9.85e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 55.13  E-value: 9.85e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272  94 VLDPMCGLGTILLEAAkEWPDVYYVGADVSDSQLlGTWDNLKAAGLEDKIELLKISVIELPL-PSESVDIIISDIPFgkk 172
Cdd:cd02440    2 VLDLGCGTGALALALA-SGPGARVTGVDISPVAL-ELARKAAAALLADNVEVLKGDAEELPPeADESFDVIISDPPL--- 76

                         90       100
                 ....*....|....*....|....*.
gi 767915272 173 FKLGKDIKSILQEMERVLHVGGTIVL 198
Cdd:cd02440   77 HHLVEDLARFLEEARRLLKPGGVLVL 102
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 75-199 4.27e-09

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 55.93  E-value: 4.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272  75 RSTIAWAmaslaDIKAGAFVLDPMCGLGTILLEAAKEWPDV-YYVGADVSDSQLLGTWDNLKAAGLEDKIELLKISVIEL 153
Cdd:PRK00216  41 RKTIKWL-----GVRPGDKVLDLACGTGDLAIALAKAVGKTgEVVGLDFSEGMLAVGREKLRDLGLSGNVEFVQGDAEAL 115

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 767915272 154 PLPSESVDII-ISdipFGkkfkLG--KDIKSILQEMERVLHVGGTIVLL 199
Cdd:PRK00216 116 PFPDNSFDAVtIA---FG----LRnvPDIDKALREMYRVLKPGGRLVIL 157
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 95-198 1.12e-08

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 51.51  E-value: 1.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272   95 LDPMCGLGTILLEAAKEWPDVYyvGADVSDSQLlgtwDNLKAAGLEDKIELLKISVIELPLPSESVDIIISdipfgkKFK 174
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVT--GVDISPEML----ELAREKAPREGLTFVVGDAEDLPFPDNSFDLVLS------SEV 68

                          90       100
                  ....*....|....*....|....*.
gi 767915272  175 LG--KDIKSILQEMERVLHVGGTIVL 198
Cdd:pfam08241  69 LHhvEDPERALREIARVLKPGGILII 94
PRK08317 PRK08317
hypothetical protein; Provisional
 84-199 1.13e-08

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 54.56  E-value: 1.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272  84 SLADIKAGAFVLDPMCGLGTILLEAAKE-WPDVYYVGADVSDSQLLGTwdNLKAAGLEDKIELLKISVIELPLPSESVDI 162
Cdd:PRK08317  13 ELLAVQPGDRVLDVGCGPGNDARELARRvGPEGRVVGIDRSEAMLALA--KERAAGLGPNVEFVRGDADGLPFPDGSFDA 90

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 767915272 163 IISDipfgKKFKLGKDIKSILQEMERVLHVGGTIVLL 199
Cdd:PRK08317  91 VRSD----RVLQHLEDPARALAEIARVLRPGGRVVVL 123
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 94-194 2.28e-08

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 50.64  E-value: 2.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272   94 VLDPMCGLGTILLEAAKEWpDVYYVGADVSDSQLLGTWDNLKAAGLedKIELLKISVIELPLPSESVDIIISDIPFGkkF 173
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRG-GARVTGVDLSPEMLERARERAAEAGL--NVEFVQGDAEDLPFPDGSFDLVVSSGVLH--H 75

                          90       100
                  ....*....|....*....|.
gi 767915272  174 KLGKDIKSILQEMERVLHVGG 194
Cdd:pfam13649  76 LPDPDLEAALREIARVLKPGG 96
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 82-198 1.20e-07

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 50.31  E-value: 1.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272  82 MASLADIKAGAFVLDPMCGLGTILLEAAKEWpDVYYVGADVSDSQLLGTWDNLKAAGLEDKIELLKISVIELPlPSESVD 161
Cdd:COG2230   43 ILRKLGLKPGMRVLDIGCGWGGLALYLARRY-GVRVTGVTLSPEQLEYARERAAEAGLADRVEVRLADYRDLP-ADGQFD 120

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 767915272 162 IIISdipfgkkfkLG-------KDIKSILQEMERVLHVGGTIVL 198
Cdd:COG2230  121 AIVS---------IGmfehvgpENYPAYFAKVARLLKPGGRLLL 155
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 88-198 4.97e-07

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 47.70  E-value: 4.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272  88 IKAGAFVLDPMCGLGTILLEAAKEWPDVyyVGADVSDSQLlgtwDNLKAAGLEDKIELLKISVIELPLPSESVDIIIS-- 165
Cdd:COG2227   22 LPAGGRVLDVGCGTGRLALALARRGADV--TGVDISPEAL----EIARERAAELNVDFVQGDLEDLPLEDGSFDLVICse 95

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767915272 166 ---DIPfgkkfklgkDIKSILQEMERVLHVGGTIVL 198
Cdd:COG2227   96 vleHLP---------DPAALLRELARLLKPGGLLLL 122
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 83-229 6.97e-07

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 48.76  E-value: 6.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272  83 ASLADIKAGAFVLDPMCGLGTILLEAAKEwPDVYYVGADVSDSQLLGTWDNLKAAGLeDKIELLKISVIEL-PLPSESVD 161
Cdd:COG0500   19 ALLERLPKGGRVLDLGCGTGRNLLALAAR-FGGRVIGIDLSPEAIALARARAAKAGL-GNVEFLVADLAELdPLPAESFD 96

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767915272 162 IIIS-----DIPFGKkfklgkdIKSILQEMERVLHVGGtIVLLLSEDHHRRLTDCKESNIPFNSKDSHTDEPG 229
Cdd:COG0500   97 LVVAfgvlhHLPPEE-------REALLRELARALKPGG-VLLLSASDAAAALSLARLLLLATASLLELLLLLR 161
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 88-198 3.44e-06

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 45.87  E-value: 3.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272   88 IKAGAFVLDPMCGLGTILLEAAKE-WPDVYYVGADVSDSQLLGTWDNLKAAGLED-KIELLKISVIELPLPSESVDIIIS 165
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEElGPNAEVVGIDISEEAIEKARENAQKLGFDNvEFEQGDIEELPELLEDDKFDVVIS 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 767915272  166 DipfgKKFKLGKDIKSILQEMERVLHVGGTIVL 198
Cdd:pfam13847  81 N----CVLNHIPDPDKVLQEILRVLKPGGRLII 109
rlmL PRK11783
bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2)) ...
 62-170 1.41e-05

bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL;


Pssm-ID: 236981 [Multi-domain]  Cd Length: 702  Bit Score: 46.33  E-value: 1.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272  62 SLASRAYIKTAG---LRSTIAWAMASLAD-IKAGAFVLDPMCGLGTILLEAA------------KEW------------- 112
Cdd:PRK11783 158 SLHQRGYRQATGeapLKENLAAAILLRSGwPQEGTPLLDPMCGSGTLLIEAAmmaadiapglhrERWgfsgwlghdealw 237

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767915272 113 -----------------PDVYYVGADvSDSQLLGT-WDNLKAAGLEDKIELLKISVIEL--PLPSESVDIIISDIPFG 170
Cdd:PRK11783 238 qelleeaqeraraglaeLPSKFYGSD-IDPRVIQAaRKNARRAGVAELITFEVKDVADLknPLPKGPTGLVISNPPYG 314
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
89-199 2.42e-05

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 44.74  E-value: 2.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272   89 KAGAFVLDPMCGLGTI---LLEAAKEWPDVyyVGADVSDSQLLGTWDNLKAAGLEDkIELLKISVIELPLPSESVDIIIs 165
Cdd:pfam01209  41 KRGNKFLDVAGGTGDWtfgLSDSAGSSGKV--VGLDINENMLKEGEKKAKEEGKYN-IEFLQGNAEELPFEDDSFDIVT- 116

                          90       100       110
                  ....*....|....*....|....*....|....
gi 767915272  166 dIPFGkkFKLGKDIKSILQEMERVLHVGGTIVLL 199
Cdd:pfam01209 117 -ISFG--LRNFPDYLKVLKEAFRVLKPGGRVVCL 147
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 78-198 1.01e-04

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 42.84  E-value: 1.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272  78 IAWAMAsLADIKAGAFVLDPMCGLGTILLEAAKEWPDVYYVGADVSDSQLLGTWDNLKaAGLEDKIELLKISVIElPLPS 157
Cdd:PRK09328  97 VEWALE-ALLLKEPLRVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAK-HGLGARVEFLQGDWFE-PLPG 173

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767915272 158 ESVDIIISD---IPFGKKFKL---------------GKD----IKSILQEMERVLHVGGTIVL 198
Cdd:PRK09328 174 GRFDLIVSNppyIPEADIHLLqpevrdhephlalfgGEDgldfYRRIIEQAPRYLKPGGWLLL 236
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 78-165 1.54e-04

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 42.44  E-value: 1.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272  78 IAWAMASLADIKAgAFVLDpmcgLGT----ILLEAAKEWPDVYYVGADVSDSQLLGTWDNLKAAGLEDKIELLKISVIEl 153
Cdd:COG2890  101 VELALALLPAGAP-PRVLD----LGTgsgaIALALAKERPDARVTAVDISPDALAVARRNAERLGLEDRVRFLQGDLFE- 174

                         90
                 ....*....|...
gi 767915272 154 PLPS-ESVDIIIS 165
Cdd:COG2890  175 PLPGdGRFDLIVS 187
arsM PRK11873
arsenite methyltransferase;
85-194 3.15e-04

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 41.47  E-value: 3.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272  85 LADIKAGAFVLDPMCGLG-TILLEAAKEWPDVYYVGADVSDSQLLGTWDNLKAAGLEDkIELLKISVIELPLPSESVDII 163
Cdd:PRK11873  72 LAELKPGETVLDLGSGGGfDCFLAARRVGPTGKVIGVDMTPEMLAKARANARKAGYTN-VEFRLGEIEALPVADNSVDVI 150

                         90       100       110
                 ....*....|....*....|....*....|...
gi 767915272 164 ISD--IpfgkkfKLGKDIKSILQEMERVLHVGG 194
Cdd:PRK11873 151 ISNcvI------NLSPDKERVFKEAFRVLKPGG 177
HsdM COG0286
Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];
78-177 3.84e-04

Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];


Pssm-ID: 440055 [Multi-domain]  Cd Length: 243  Bit Score: 40.94  E-value: 3.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272  78 IAWAMASLADIKAGAFVLDPMCGLGTILLEAAK--------EWPDVYYVGADVSDSqllgTWD----NLKAAGLEDKIEL 145
Cdd:COG0286   31 VVRLMVELLDPKPGETVYDPACGSGGFLVEAAEylkehggdERKKLSLYGQEINPT----TYRlakmNLLLHGIGDPNIE 106

                         90       100       110
                 ....*....|....*....|....*....|..
gi 767915272 146 LKISVIELPLPSESVDIIISDIPFGKKFKLGK 177
Cdd:COG0286  107 LGDTLSNDGDELEKFDVVLANPPFGGKWKKEE 138
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 94-169 4.66e-04

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 40.27  E-value: 4.66e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767915272   94 VLDPMCGLGTILLEAAKEWPDVYYVGADVSDSQLLGTWDNLKAAGLEDkIELLKISVIElPLPSESVDIIISDIPF 169
Cdd:pfam05175  35 VLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGLEN-GEVVASDVYS-GVEDGKFDLIISNPPF 108
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 94-198 4.84e-04

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 40.17  E-value: 4.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272  94 VLDPMCGLGTILLEAAKEWPDVYYVGADVSDSQLLGTWDNLKAAGLEDkIELLKISVIElPLPSESVDIIISDIPfgkkF 173
Cdd:COG2813   53 VLDLGCGYGVIGLALAKRNPEARVTLVDVNARAVELARANAAANGLEN-VEVLWSDGLS-GVPDGSFDLILSNPP----F 126

                         90       100       110
                 ....*....|....*....|....*....|
gi 767915272 174 KLGKDI-KSILQEM----ERVLHVGGTIVL 198
Cdd:COG2813  127 HAGRAVdKEVAHALiadaARHLRPGGELWL 156
CMAS pfam02353
Mycolic acid cyclopropane synthetase; This family consist of ...
 86-165 5.51e-04

Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.


Pssm-ID: 396777 [Multi-domain]  Cd Length: 272  Bit Score: 40.77  E-value: 5.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272   86 ADIKAGAFVLDPMCGLGTILLEAAKEWpDVYYVGADVSDSQLLGTWDNLKAAGLEDKIELLKISVIELPlpsESVDIIIS 165
Cdd:pfam02353  57 LGLKPGMTLLDIGCGWGGLMRRAAERY-DVNVVGLTLSKNQYKLARKRVAAEGLARKVEVLLQDYRDFD---EPFDRIVS 132
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 99-196 1.80e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 36.96  E-value: 1.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272   99 CGLGTILLEAAKEWPDVYYVGADVSDSQLLGTWDNLKAAGLED--KIELLKISVIELPLPseSVDIIISdipfgkkfkLG 176
Cdd:pfam08242   5 CGTGTLLRALLEALPGLEYTGLDISPAALEAARERLAALGLLNavRVELFQLDLGELDPG--SFDVVVA---------SN 73

                          90       100
                  ....*....|....*....|....*
gi 767915272  177 -----KDIKSILQEMERVLHVGGTI 196
Cdd:pfam08242  74 vlhhlADPRAVLRNIRRLLKPGGVL 98
YhdJ COG0863
DNA modification methylase [Replication, recombination and repair];
155-198 2.89e-03

DNA modification methylase [Replication, recombination and repair];


Pssm-ID: 440623  Cd Length: 236  Bit Score: 38.37  E-value: 2.89e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272 155 LPSESVDIIISDIPF--GKKFKLGKD--------------IKSILQEMERVLHVGGTIVL 198
Cdd:COG0863   14 LPDESVDLIVTDPPYnlGKKYGLGRReignelsfeeylefLREWLAECYRVLKPGGSLYV 73
PRK14968 PRK14968
putative methyltransferase; Provisional
 82-201 8.44e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 36.42  E-value: 8.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915272  82 MASLADIKAGAFVLDPMCGLGTILLEAAKEWPDVyyVGADVSDSQLLGTWDNLKAAGLEDKiellKISVIE----LPLPS 157
Cdd:PRK14968  15 LAENAVDKKGDRVLEVGTGSGIVAIVAAKNGKKV--VGVDINPYAVECAKCNAKLNNIRNN----GVEVIRsdlfEPFRG 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767915272 158 ESVDIIISDIPF-------------GKKFKLGKD----IKSILQEMERVLHVGGTIVLLLS 201
Cdd:PRK14968  89 DKFDVILFNPPYlpteeeeewddwlNYALSGGKDgrevIDRFLDEVGRYLKPGGRILLLQS 149
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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