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Conserved domains on  [gi|767922474|ref|XP_011531720|]
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coiled-coil domain-containing protein 13 isoform X2 [Homo sapiens]

Protein Classification

coiled-coil domain-containing protein( domain architecture ID 1000095)

coiled-coil domain-containing protein contains a region with alpha-helical coiled-coil sequence signatures that is being annotated by a variety of protein family models, not necessarily indicating family membership

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 103-454 2.44e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 63.92  E-value: 2.44e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   103 ERDFEIKHLKKKIEEDRFAFTgTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLSAK 182
Cdd:TIGR02168  674 ERRREIEELEEKIEELEEKIA-ELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQL 752

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   183 GATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQELRMAQKVLAREvgedinvqqllsspgtw 262
Cdd:TIGR02168  753 SKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLL----------------- 815

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   263 RGRAQQilvLQSKVQELEKQlgqarsqsagtasdelsvypdprkLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQREL 342
Cdd:TIGR02168  816 NEEAAN---LRERLESLERR------------------------IAATERRLEDLEEQIEELSEDIESLAAEIEELEELI 868

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   343 EELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSE 422
Cdd:TIGR02168  869 EELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEE 948

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 767922474   423 AQRSNSLVAQLQAMV----AEREAKVRQLEMEIGQL 454
Cdd:TIGR02168  949 YSLTLEEAEALENKIeddeEEARRRLKRLENKIKEL 984
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 103-454 2.44e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 63.92  E-value: 2.44e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   103 ERDFEIKHLKKKIEEDRFAFTgTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLSAK 182
Cdd:TIGR02168  674 ERRREIEELEEKIEELEEKIA-ELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQL 752

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   183 GATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQELRMAQKVLAREvgedinvqqllsspgtw 262
Cdd:TIGR02168  753 SKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLL----------------- 815

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   263 RGRAQQilvLQSKVQELEKQlgqarsqsagtasdelsvypdprkLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQREL 342
Cdd:TIGR02168  816 NEEAAN---LRERLESLERR------------------------IAATERRLEDLEEQIEELSEDIESLAAEIEELEELI 868

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   343 EELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSE 422
Cdd:TIGR02168  869 EELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEE 948

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 767922474   423 AQRSNSLVAQLQAMV----AEREAKVRQLEMEIGQL 454
Cdd:TIGR02168  949 YSLTLEEAEALENKIeddeEEARRRLKRLENKIKEL 984
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 142-448 2.05e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 57.64  E-value: 2.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474 142 KKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLSAKGATdagakppRAQMGDRALLETPEVKALQDRLVATNLKM 221
Cdd:COG1196  225 LEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAE-------LEELRLELEELELELEEAQAEEYELLAEL 297

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474 222 SDLRNQIQSVKQELRMAQKVLAREVGEDINVQQLLsspgtwRGRAQQILVLQSKVQELEKQLGQARSQsagtasdelsvy 301
Cdd:COG1196  298 ARLEQDIARLEERRRELEERLEELEEELAELEEEL------EELEEELEELEEELEEAEEELEEAEAE------------ 359

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474 302 pdprkLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDD 381
Cdd:COG1196  360 -----LAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELE 434

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767922474 382 ELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLE 448
Cdd:COG1196  435 EEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEA 501
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 2-460 1.33e-04

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 45.11  E-value: 1.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474     2 AADESSQNTLRLQFKAMQEMQHKRLQK---QMEKKREKELSLKSRADDQEEPLEVSDGlsllHAGEPNSKNSFEKRVLED 78
Cdd:pfam15921  249 ALKSESQNKIELLLQQHQDRIEQLISEhevEITGLTEKASSARSQANSIQSQLEIIQE----QARNQNSMYMRQLSDLES 324

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474    79 EIEHLRNELRETvdengrlykllkerdfeikhlkKKIEEDrfaftgtagvagdvvatKIVELSKKNRLLMAESEGAKTRV 158
Cdd:pfam15921  325 TVSQLRSELREA----------------------KRMYED-----------------KIEELEKQLVLANSELTEARTER 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   159 KQLTNRIQELERELQTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQELR-M 237
Cdd:pfam15921  366 DQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDDRNMEVQRLEALLKAMKSECQgQ 445

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   238 AQKVLAREVGEDINVQQLLSSPGTwrgraqqilvLQSKVQELEKQLGQARSQSAGTASDELSVypDPRKLSAQEKNllri 317
Cdd:pfam15921  446 MERQMAAIQGKNESLEKVSSLTAQ----------LESTKEMLRKVVEELTAKKMTLESSERTV--SDLTASLQEKE---- 509

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   318 RSLEREKQEgLEKLASERDVLQRELEELKKKFEGMRSrnklLSSEMKTLKSQMGtlvekgrHDDELIDALMDQLKQLQEI 397
Cdd:pfam15921  510 RAIEATNAE-ITKLRSRVDLKLQELQHLKNEGDHLRN----VQTECEALKLQMA-------EKDKVIEILRQQIENMTQL 577

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767922474   398 LGSLSLQEEKTRVSQHHLDQQLNSEAQRsnslVAQLQAMVAEREAKVRQLEMEIGQLNVHYLR 460
Cdd:pfam15921  578 VGQHGRTAGAMQVEKAQLEKEINDRRLE----LQEFKILKDKKDAKIRELEARVSDLELEKVK 636
PRK12704 PRK12704
phosphodiesterase; Provisional
 280-446 3.16e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 43.61  E-value: 3.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474 280 EKQLGQARSQSAGT---ASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLAS-ERDVLQRElEELKKKFEGMRSR 355
Cdd:PRK12704  30 EAKIKEAEEEAKRIleeAKKEAEAIKKEALLEAKEEIHKLRNEFEKELRERRNELQKlEKRLLQKE-ENLDRKLELLEKR 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474 356 NKLLSSEMKTLKSQMGTLVEKgrhDDELIDALMDQLKQLQEILGsLSLQEEKTRvsqhhLDQQLNSEAQrsnslvAQLQA 435
Cdd:PRK12704 109 EEELEKKEKELEQKQQELEKK---EEELEELIEEQLQELERISG-LTAEEAKEI-----LLEKVEEEAR------HEAAV 173

                        170
                 ....*....|.
gi 767922474 436 MVAEREAKVRQ 446
Cdd:PRK12704 174 LIKEIEEEAKE 184
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 103-454 2.44e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 63.92  E-value: 2.44e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   103 ERDFEIKHLKKKIEEDRFAFTgTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLSAK 182
Cdd:TIGR02168  674 ERRREIEELEEKIEELEEKIA-ELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQL 752

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   183 GATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQELRMAQKVLAREvgedinvqqllsspgtw 262
Cdd:TIGR02168  753 SKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLL----------------- 815

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   263 RGRAQQilvLQSKVQELEKQlgqarsqsagtasdelsvypdprkLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQREL 342
Cdd:TIGR02168  816 NEEAAN---LRERLESLERR------------------------IAATERRLEDLEEQIEELSEDIESLAAEIEELEELI 868

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   343 EELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSE 422
Cdd:TIGR02168  869 EELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEE 948

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 767922474   423 AQRSNSLVAQLQAMV----AEREAKVRQLEMEIGQL 454
Cdd:TIGR02168  949 YSLTLEEAEALENKIeddeEEARRRLKRLENKIKEL 984
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 142-448 2.05e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 57.64  E-value: 2.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474 142 KKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLSAKGATdagakppRAQMGDRALLETPEVKALQDRLVATNLKM 221
Cdd:COG1196  225 LEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAE-------LEELRLELEELELELEEAQAEEYELLAEL 297

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474 222 SDLRNQIQSVKQELRMAQKVLAREVGEDINVQQLLsspgtwRGRAQQILVLQSKVQELEKQLGQARSQsagtasdelsvy 301
Cdd:COG1196  298 ARLEQDIARLEERRRELEERLEELEEELAELEEEL------EELEEELEELEEELEEAEEELEEAEAE------------ 359

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474 302 pdprkLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDD 381
Cdd:COG1196  360 -----LAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELE 434

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767922474 382 ELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLE 448
Cdd:COG1196  435 EEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEA 501
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
144-355 2.12e-06

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 50.79  E-value: 2.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474 144 NRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLSA-KGATDAgakpprAQMGDRALLETPEVKALQDRLVATNLKMS 222
Cdd:COG3206  163 EQNLELRREEARKALEFLEEQLPELRKELEEAEAALEEfRQKNGL------VDLSEEAKLLLQQLSELESQLAEARAELA 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474 223 DLRNQIQSVKQELRMAQKVLArEVGEDINVQQLLSSPGTWRGRAQQILV-----------LQSKVQELEKQLGQARSQSA 291
Cdd:COG3206  237 EAEARLAALRAQLGSGPDALP-ELLQSPVIQQLRAQLAELEAELAELSArytpnhpdviaLRAQIAALRAQLQQEAQRIL 315

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767922474 292 GTASDELSVypdprkLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGMRSR 355
Cdd:COG3206  316 ASLEAELEA------LQAREASLQAQLAQLEARLAELPELEAELRRLEREVEVARELYESLLQR 373
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
154-370 2.40e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 51.07  E-value: 2.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474  154 AKTRVKQLTnRIQELERELQTALTRLSAKGATDAGAKPPRAQMgdRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQ 233
Cdd:COG4913   247 AREQIELLE-PIRELAERYAAARERLAELEYLRAALRLWFAQR--RLELLEAELEELRAELARLEAELERLEARLDALRE 323

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474  234 ELRMAQKVLAREVGEDInvQQLlsspgtwrgrAQQILVLQSKVQELEKQLGQARSQsagTASDELSVYPDPRKLSAQEKN 313
Cdd:COG4913   324 ELDELEAQIRGNGGDRL--EQL----------EREIERLERELEERERRRARLEAL---LAALGLPLPASAEEFAALRAE 388

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767922474  314 LLRIRSLEREKQEGLEKLASERDV----LQRELEELKKKFEGMRSRNKLLSSEMKTLKSQM 370
Cdd:COG4913   389 AAALLEALEEELEALEEALAEAEAalrdLRRELRELEAEIASLERRKSNIPARLLALRDAL 449
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 267-539 7.43e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 49.28  E-value: 7.43e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   267 QQILVLQSKVQELEKQLGQARSQSAGTASDELSVYPDPRKLSAQEKNLLRirSLEREKQEgLEKLASERDVLQRELEELK 346
Cdd:TIGR02168  684 EKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRK--DLARLEAE-VEQLEERIAQLSKELTELE 760

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   347 KKFEGMRSRNKLLSSEMKTLKSQMGTLvekgrhdDELIDALMDQLKQLQEILGSLSLQEektrvsqhhldQQLNSEAQRS 426
Cdd:TIGR02168  761 AEIEELEERLEEAEEELAEAEAEIEEL-------EAQIEQLKEELKALREALDELRAEL-----------TLLNEEAANL 822

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   427 NSLVAQLQAMVAEREAKVRQLEMEIGQLNVHYLRNKGV--GEGSSGREVSPAYTQFLEDPGLTKSPASAGDHVGRLGSSR 504
Cdd:TIGR02168  823 RERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEieELEELIEELESELEALLNERASLEEALALLRSELEELSEE 902

                          250       260       270
                   ....*....|....*....|....*....|....*
gi 767922474   505 VEESNSKLLESERKLQEERHRTVVLEQHLEKIRLE 539
Cdd:TIGR02168  903 LRELESKRSELRRELEELREKLAQLELRLEGLEVR 937
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 255-455 1.23e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 47.84  E-value: 1.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474 255 LLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGTASDELSVYPDPRKLSAQEKNLLR-IRSLERE---KQEGLEK 330
Cdd:COG4942    8 ALLLALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARrIRALEQElaaLEAELAE 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474 331 LASERDVLQRELEELKKKFE---------GMRSRNKLL--SSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILG 399
Cdd:COG4942   88 LEKEIAELRAELEAQKEELAellralyrlGRQPPLALLlsPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRA 167

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767922474 400 SLSLQEEKTRVSQHHLDQQ---LNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLN 455
Cdd:COG4942  168 ELEAERAELEALLAELEEEraaLEALKAERQKLLARLEKELAELAAELAELQQEAEELE 226
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 72-539 1.87e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 48.01  E-value: 1.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474  72 EKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTGTAGVAGDVVATKIVELSKKNRLLmAES 151
Cdd:COG1196  240 ELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELE-ERL 318

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474 152 EGAKTRVKQLTNRIQELERELQTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSV 231
Cdd:COG1196  319 EELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAEL 398

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474 232 KQELRMAQKVLAREVGEDINVQQLLSSpgtwrgRAQQILVLQSKVQELEKQLGQARSQSAGTASDELSVYpdpRKLSAQE 311
Cdd:COG1196  399 AAQLEELEEAEEALLERLERLEEELEE------LEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALL---ELLAELL 469

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474 312 KNLLRIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKgRHDDELIDALMDQL 391
Cdd:COG1196  470 EEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEA-AYEAALEAALAAAL 548

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474 392 KQLQ-------EILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEME---IGQLNVHYLRN 461
Cdd:COG1196  549 QNIVveddevaAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARyyvLGDTLLGRTLV 628

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474 462 KGVGEGSSGREVSPAYTQ---FLEDPGLTKSPASAGDHVGRLGSSRVEESNSKLLESERKLQEERHRTVVLEQHLEKIRL 538
Cdd:COG1196  629 AARLEAALRRAVTLAGRLrevTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERE 708


                 .
gi 767922474 539 E 539
Cdd:COG1196  709 L 709
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 146-449 1.94e-05

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 48.14  E-value: 1.94e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   146 LLMAESEGAKTRVKQLTNRIQELERELQTALTRLSAKGATDAGAKPPRAQMGDRALLETP-EVKALQDRLVATNLKMSDL 224
Cdd:TIGR02169  227 ELLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEeEQLRVKEKIGELEAEIASL 306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   225 RNQIQSVKQELRMAQKVLAREVGE----DINVQQLLSSPGTWRGRAQQilvLQSKVQELEKQLGQARSQsagtasdelsv 300
Cdd:TIGR02169  307 ERSIAEKERELEDAEERLAKLEAEidklLAEIEELEREIEEERKRRDK---LTEEYAELKEELEDLRAE----------- 372

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   301 ypdprkLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHD 380
Cdd:TIGR02169  373 ------LEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDK 446

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767922474   381 DELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEM 449
Cdd:TIGR02169  447 ALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEV 515
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 305-454 1.13e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 45.31  E-value: 1.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474 305 RKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELI 384
Cdd:COG1196  232 LKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERR 311

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474 385 DALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQL 454
Cdd:COG1196  312 RELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEEL 381
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 83-402 1.27e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 45.43  E-value: 1.27e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474    83 LRNELRETvdENGRLYKLLKERDFEIKHLKKKI---EEDRFAFTGTAgvagDVVATKIVELSKKNRLLMAESEGAKTRVK 159
Cdd:TIGR02168  218 LKAELREL--ELALLVLRLEELREELEELQEELkeaEEELEELTAEL----QELEEKLEELRLEVSELEEEIEELQKELY 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   160 QLTNRIQELERELQTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLvatnlkmSDLRNQIQSVKQEL-RMA 238
Cdd:TIGR02168  292 ALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKL-------EELKEELESLEAELeELE 364

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   239 QKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLgqarSQSAGTASDELSVYPDPRKlSAQEKNLLRIR 318
Cdd:TIGR02168  365 AELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARL----ERLEDRRERLQQEIEELLK-KLEEAELKELQ 439

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   319 SLEREKQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQ---MGTLVEKGRHDDELIDALMDQLKQLQ 395
Cdd:TIGR02168  440 AELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARldsLERLQENLEGFSEGVKALLKNQSGLS 519


                   ....*..
gi 767922474   396 EILGSLS 402
Cdd:TIGR02168  520 GILGVLS 526
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 2-460 1.33e-04

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 45.11  E-value: 1.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474     2 AADESSQNTLRLQFKAMQEMQHKRLQK---QMEKKREKELSLKSRADDQEEPLEVSDGlsllHAGEPNSKNSFEKRVLED 78
Cdd:pfam15921  249 ALKSESQNKIELLLQQHQDRIEQLISEhevEITGLTEKASSARSQANSIQSQLEIIQE----QARNQNSMYMRQLSDLES 324

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474    79 EIEHLRNELRETvdengrlykllkerdfeikhlkKKIEEDrfaftgtagvagdvvatKIVELSKKNRLLMAESEGAKTRV 158
Cdd:pfam15921  325 TVSQLRSELREA----------------------KRMYED-----------------KIEELEKQLVLANSELTEARTER 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   159 KQLTNRIQELERELQTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQELR-M 237
Cdd:pfam15921  366 DQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDDRNMEVQRLEALLKAMKSECQgQ 445

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   238 AQKVLAREVGEDINVQQLLSSPGTwrgraqqilvLQSKVQELEKQLGQARSQSAGTASDELSVypDPRKLSAQEKNllri 317
Cdd:pfam15921  446 MERQMAAIQGKNESLEKVSSLTAQ----------LESTKEMLRKVVEELTAKKMTLESSERTV--SDLTASLQEKE---- 509

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   318 RSLEREKQEgLEKLASERDVLQRELEELKKKFEGMRSrnklLSSEMKTLKSQMGtlvekgrHDDELIDALMDQLKQLQEI 397
Cdd:pfam15921  510 RAIEATNAE-ITKLRSRVDLKLQELQHLKNEGDHLRN----VQTECEALKLQMA-------EKDKVIEILRQQIENMTQL 577

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767922474   398 LGSLSLQEEKTRVSQHHLDQQLNSEAQRsnslVAQLQAMVAEREAKVRQLEMEIGQLNVHYLR 460
Cdd:pfam15921  578 VGQHGRTAGAMQVEKAQLEKEINDRRLE----LQEFKILKDKKDAKIRELEARVSDLELEKVK 636
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
266-448 2.05e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 44.52  E-value: 2.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474  266 AQQILVLQSKVQELEKQLGQARSQSAgTASDELSVYPDPRKLSAQEKNLL----RIRSLEREKQEgLEKLASERDVLQRE 341
Cdd:COG4913   616 EAELAELEEELAEAEERLEALEAELD-ALQERREALQRLAEYSWDEIDVAsaerEIAELEAELER-LDASSDDLAALEEQ 693

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474  342 LEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVekgrhddELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDqqlNS 421
Cdd:COG4913   694 LEELEAELEELEEELDELKGEIGRLEKELEQAE-------EELDELQDRLEAAEDLARLELRALLEERFAAALGD---AV 763

                         170       180
                  ....*....|....*....|....*..
gi 767922474  422 EAQRSNSLVAQLQAMVAEREAKVRQLE 448
Cdd:COG4913   764 ERELRENLEERIDALRARLNRAEEELE 790
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 306-550 2.07e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 44.66  E-value: 2.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   306 KLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELID 385
Cdd:TIGR02168  233 RLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLA 312

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   386 ALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREA-----------------KVRQLE 448
Cdd:TIGR02168  313 NLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEElesrleeleeqletlrsKVAQLE 392

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   449 MEIGQLNVHYLRNKGVGEGSSGRevspaytqfledpgLTKSPASAGDHVGRLGSSRVEESNSKLLESERKLQEERHRTVV 528
Cdd:TIGR02168  393 LQIASLNNEIERLEARLERLEDR--------------RERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELER 458

                          250       260
                   ....*....|....*....|..
gi 767922474   529 LEQHLEKIRLEPGKASASQRAA 550
Cdd:TIGR02168  459 LEEALEELREELEEAEQALDAA 480
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 287-455 2.48e-04

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 44.56  E-value: 2.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474  287 RSQSAGTASDELSVYPDPRKLSAQEKnllrirSLEREKQEgLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTL 366
Cdd:COG3096   490 RSQAWQTARELLRRYRSQQALAQRLQ------QLRAQLAE-LEQRLRQQQNAERLLEEFCQRIGQQLDAAEELEELLAEL 562

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474  367 KSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQ---HHLDQQLNSEAQRSNSLVAQLQAMV-AEREA 442
Cdd:COG3096   563 EAQLEELEEQAAEAVEQRSELRQQLEQLRARIKELAARAPAWLAAQdalERLREQSGEALADSQEVTAAMQQLLeREREA 642

                         170       180
                  ....*....|....*....|..
gi 767922474  443 KV---------RQLEMEIGQLN 455
Cdd:COG3096   643 TVerdelaarkQALESQIERLS 664
PRK12704 PRK12704
phosphodiesterase; Provisional
 280-446 3.16e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 43.61  E-value: 3.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474 280 EKQLGQARSQSAGT---ASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLAS-ERDVLQRElEELKKKFEGMRSR 355
Cdd:PRK12704  30 EAKIKEAEEEAKRIleeAKKEAEAIKKEALLEAKEEIHKLRNEFEKELRERRNELQKlEKRLLQKE-ENLDRKLELLEKR 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474 356 NKLLSSEMKTLKSQMGTLVEKgrhDDELIDALMDQLKQLQEILGsLSLQEEKTRvsqhhLDQQLNSEAQrsnslvAQLQA 435
Cdd:PRK12704 109 EEELEKKEKELEQKQQELEKK---EEELEELIEEQLQELERISG-LTAEEAKEI-----LLEKVEEEAR------HEAAV 173

                        170
                 ....*....|.
gi 767922474 436 MVAEREAKVRQ 446
Cdd:PRK12704 174 LIKEIEEEAKE 184
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 305-448 5.60e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.39  E-value: 5.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474 305 RKLSAQEKNLLRIRSLEREKQEGLEKLASERDV------LQRELEELK-----KKFEGMRSRNKLLSSEMKTLKSQMGTL 373
Cdd:COG1196  179 RKLEATEENLERLEDILGELERQLEPLERQAEKaeryreLKEELKELEaelllLKLRELEAELEELEAELEELEAELEEL 258

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767922474 374 VEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLE 448
Cdd:COG1196  259 EAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELE 333
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 214-446 8.00e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 42.06  E-value: 8.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474 214 LVATNLKMSDLRNQIQSVKQELRMAQKVLAREVGEDINVQQLLSSpgtwrgRAQQILVLQSKVQELEKQLGQARSQSAGT 293
Cdd:COG4942   15 AAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAA------LERRIAALARRIRALEQELAALEAELAEL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474 294 ASDELSVYpdpRKLSAQEKNL-LRIRSLER-EKQEGLEKLASERDVLQ--RELEELKKKFEGMRSRNKLLSSEMKTLKSQ 369
Cdd:COG4942   89 EKEIAELR---AELEAQKEELaELLRALYRlGRQPPLALLLSPEDFLDavRRLQYLKYLAPARREQAEELRADLAELAAL 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767922474 370 MGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQ 446
Cdd:COG4942  166 RAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAER 242
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 155-442 8.21e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 42.75  E-value: 8.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   155 KTRVKQLTNRIQELERELQTALTRL-SAKGATDAGAKPPRAQMGDRALLETpEVKALQDRLVATNLKMSDLRNQIQSVKQ 233
Cdd:TIGR02169  673 PAELQRLRERLEGLKRELSSLQSELrRIENRLDELSQELSDASRKIGEIEK-EIEQLEQEEEKLKERLEELEEDLSSLEQ 751

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   234 EL----RMAQKVLAR--EVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGTASDELSVYPDPRKL 307
Cdd:TIGR02169  752 EIenvkSELKELEARieELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYL 831

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   308 SAQEKNLLRIRSL----EREKQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDEL 383
Cdd:TIGR02169  832 EKEIQELQEQRIDlkeqIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQ 911

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 767922474   384 IDALMDQLKQLQEILGSLSlQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREA 442
Cdd:TIGR02169  912 IEKKRKRLSELKAKLEALE-EELSEIEDPKGEDEEIPEEELSLEDVQAELQRVEEEIRA 969
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
202-439 9.42e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.59  E-value: 9.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474  202 LETPEVKALQDRLVA--TNLK-----MSDLRNQIQSVKQELRMAQKvlAREVGEDINVQQLLSSPGTWRGRAQQILVLQS 274
Cdd:COG4913   218 LEEPDTFEAADALVEhfDDLEraheaLEDAREQIELLEPIRELAER--YAAARERLAELEYLRAALRLWFAQRRLELLEA 295

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474  275 KVQELEKQLGQARSQSAgtasdelsvypdprKLSAQEKNLL-RIRSLEREKQE----GLEKLASERDVLQRELEELKKKF 349
Cdd:COG4913   296 ELEELRAELARLEAELE--------------RLEARLDALReELDELEAQIRGnggdRLEQLEREIERLERELEERERRR 361

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474  350 EGMRSRNKLLSSEMKTLKSQMGTLVEKGRhddELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSL 429
Cdd:COG4913   362 ARLEALLAALGLPLPASAEEFAALRAEAA---ALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNI 438

                         250
                  ....*....|
gi 767922474  430 VAQLQAMVAE 439
Cdd:COG4913   439 PARLLALRDA 448
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 219-450 2.35e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.08  E-value: 2.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474 219 LKMSDLRNQIQSVKQELRMAQKVLAREVGEdinvqqllsspgtWRGRAQQILVLQSKVQELEKQLGQARSQSAGTASDEL 298
Cdd:COG1196  232 LKLRELEAELEELEAELEELEAELEELEAE-------------LAELEAELEELRLELEELELELEEAQAEEYELLAELA 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474 299 SVYPDPRKLSAQEKNLL-RIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKG 377
Cdd:COG1196  299 RLEQDIARLEERRRELEeRLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAE 378

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767922474 378 RHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEME 450
Cdd:COG1196  379 EELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEE 451
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 10-452 5.25e-03

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 40.10  E-value: 5.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474    10 TLRLQFKAMQEMQHKRLQKQMEK--KREKELSLKSRADDQEEPLEVSDGLSllhagepnsknsfekrvledeIEHLRNEL 87
Cdd:pfam15921  363 TERDQFSQESGNLDDQLQKLLADlhKREKELSLEKEQNKRLWDRDTGNSIT---------------------IDHLRREL 421

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474    88 RETVDENGRLYKLLK----------ERDFEIKHLKKKIEEDRFAFTGTAGVAGDVVATKIVELSKKNRLLmaesEGAKTR 157
Cdd:pfam15921  422 DDRNMEVQRLEALLKamksecqgqmERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTL----ESSERT 497

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   158 VKQLTNRIQELERELQTA---LTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQI----QS 230
Cdd:pfam15921  498 VSDLTASLQEKERAIEATnaeITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMAEKDKVIEILRQQIenmtQL 577

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   231 VKQELRMAQKVLAREVgedinvqQLLSSPGTWRGRAQQILVLQ----SKVQELEKQLGQ---ARSQSAGTASDELSVYPD 303
Cdd:pfam15921  578 VGQHGRTAGAMQVEKA-------QLEKEINDRRLELQEFKILKdkkdAKIRELEARVSDlelEKVKLVNAGSERLRAVKD 650

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   304 PRklsaQEKNLLrIRSLEREKQEgLEKLASERDVLQREL----EELKKKFEGMRSRNKLLSSEMK----TLKSQMGT--- 372
Cdd:pfam15921  651 IK----QERDQL-LNEVKTSRNE-LNSLSEDYEVLKRNFrnksEEMETTTNKLKMQLKSAQSELEqtrnTLKSMEGSdgh 724

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922474   373 -------LVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVA-EREAKV 444
Cdd:pfam15921  725 amkvamgMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSqERRLKE 804


                   ....*...
gi 767922474   445 RQLEMEIG 452
Cdd:pfam15921  805 KVANMEVA 812
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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