|
Name |
Accession |
Description |
Interval |
E-value |
| Plexin_cytopl |
pfam08337 |
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ... |
1562-2098 |
0e+00 |
|
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.
Pssm-ID: 462434 [Multi-domain] Cd Length: 500 Bit Score: 876.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1562 GIPFLDYKVYAERIFFPGHRESPLHRDLGVP---ESRRPTVEQGLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYVA 1638
Cdd:pfam08337 1 GIPFLDYRTYAMRVLFPGVEDHPLLVLLDVPvtnDGRRTNVEQALTQFSQLLNNKLFLLTFIRTLESQRSFSIRDRCNVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1639 SLLTVALHGKLEYFTDILRTLLSDLVAQYV-AKNPKLMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQ 1717
Cdd:pfam08337 81 SLLMVALHGKLEYATEILKTLLRDLIDKSVeSKNPKLLLRRTESVVEKMLTNWMSICLYPFLRECAGEPLFLLYKAIKQQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1718 VDKGPVDSVTGKAKYTLNDNRLLREDVEYRPLTLNALLAVGpgaGEAQGVPVKVLDCDTISQAKEKMLDQLYKGVPLTQR 1797
Cdd:pfam08337 161 VEKGPVDAITGKARYTLSEDKLLREQIDYKTLTLHVIFEEG---ENSESVPVKVLDCDTITQVKEKILDAIYKNTPYSQR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1798 PDPRTLDVEWRSGVAGHLILSDEDVTSEVQGLWRRLNTLQHYKqVPDGATVALVPcltkhvlrenqdyvpgertpmledv 1877
Cdd:pfam08337 238 PSIDEVDLEWRHGRGGRLTLQDEDSTSKVEGGWKKLNTLAHYK-VPDGATLALIP------------------------- 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1878 deggiRPWHLVKPSDEPEPprprrgslRGGERERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILST-SRPVPLAVKYFF 1956
Cdd:pfam08337 292 -----KYWHLVKPSDEGDQ--------RKKSERRKKAIPEIYLTRLLSTKGTLQKFVDDLFESILSVpNSALPLAVKYLF 358
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1957 DLLDEQAQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINK 2036
Cdd:pfam08337 359 DFLDEQAEKHGITDPEVLHIWKSNSLPLRFWVNIIKNPQFVFDINKSPIVDSCLSVIAQTFMDSCSTSEHRLGKDSPSNK 438
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767923571 2037 LLYARDIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYINK 2098
Cdd:pfam08337 439 LLYAKDIPRYKQMVERYYKDISNMPPISDQEMNAFLAEESRKHQNEFNTSAALKELYKYVNK 500
|
|
| Sema_plexin_B1 |
cd11275 |
The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the ... |
28-480 |
0e+00 |
|
The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D-plexin B signaling complex regulates dendritic and axonal complexity. The activation of Plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.
Pssm-ID: 200536 [Multi-domain] Cd Length: 461 Bit Score: 855.80 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 28 FTPNGTYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPDECPQAQPTNNPNQLLLVSPG- 106
Cdd:cd11275 1 FSPNGTKFLHLSMDPESGTLYLGATNFLFQLTPDLLLENMVQTGPVLDSKDCLPPVSKLECPQAQHTNNHNKLLLVNPVq 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 107 -ALVVCGSVHQGVCEQRRLGQLEQLLLRPERPGDTQYVAANDPAVSTVGLVAQGLAGEPLLFVGRGYTSRGVGGGIPPIT 185
Cdd:cd11275 81 kELIVCGSVHQGICEKRRLGSIDHVLFRPERPGDTQYVAANDPNVTTVGLVAYSKDGVPLLFVGRGYTSRGVGGGIPPIT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 186 TRALWPP-----DPQAAFSYEETAKLAVGRLSEYSHHFVSAFARGASAYFLFLRRDLQAQSRAFRAYVSRVCLRDQHYYS 260
Cdd:cd11275 161 TRNLRAHgddatDSHSIFSYEETAKLAVGRLSEYNHHFIKAFTYGSSVYFLFYRRDLKSQSREYKTYISRICLDDSHYYS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 261 YVELPLACEG--GRYGLIQAAAVATSRE-------VAHGEVLFAAFSSAAPPTVGRppsaaagaSGASALCAFPLDEVDR 331
Cdd:cd11275 241 YVELPLLCQSkaNTYSLLQAAYVTQPGErlaqgqlDTDGEVLFAAFSAWQASSGKL--------SEESALCAYPMDEVDR 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 332 LANRTRDACYTREGRAEDGTEVAYIEYDVNSDCAQLPVDTLDAYPCGSDHTPSPMASRVPLEATPILEWPGIQLTAVAVT 411
Cdd:cd11275 313 LTNWTRDVCYTRDGKAEDGTEVAYIEYDVSSNCVQLPADTLDAYPCGSDHTPSPMASRVPLEATPLLEWTEIRLTAVAVN 392
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767923571 412 MEDGHTIAFLGDSQGQLHRVYLGPGSDGHPYSTQSIQQGSAVSRDLTFDGTFEHLYVMTQSTLLKVPVA 480
Cdd:cd11275 393 VEDGHTIAFLGDSRGRLHKVYLGAGGDAHTYSSQSIQQNSAVSGDLLFDQLQEHLYVMTQSTVLKVPIA 461
|
|
| RasGAP_plexin_B1 |
cd12793 |
Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane ... |
1562-2135 |
0e+00 |
|
Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D and plexin-B1 signaling complex regulates dendritic and axonal complexity. The activation of Plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin-B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin-B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin-B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.
Pssm-ID: 213353 [Multi-domain] Cd Length: 394 Bit Score: 788.46 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1562 GIPFLDYKVYAERIFFPGHRESPLHRDLGVPESRRPTVEQGLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYVASLL 1641
Cdd:cd12793 1 GIPFLDYRMYAERIFFPGHRESPLRRDLDVPECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLESQRTFSPRDRAYVASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1642 TVALHGKLEYFTDILRTLLSDLVAQYVAKNPKLMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQVDKG 1721
Cdd:cd12793 81 TVALHGKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTETVVEKLLTNWMSICLYTFLRDSAGESLYMLFRAIKHQVDKG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1722 PVDSVTGKakytlndnrllredveyrpltlnallavgpgageaqgvpvkvldcdtisqakekmldqlykgvpltqrpdpr 1801
Cdd:cd12793 161 PVDAVTGK------------------------------------------------------------------------ 168
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1802 tldvewrsgvaghlilsdedvtsevqglwrrlntlqhykqvpdgatvalvpcltkhvlrenqdyvpgertpmledvdegg 1881
Cdd:cd12793 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1882 irpwhlvkpsdepepprprrgslrggerERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTSRPVPLAVKYFFDLLDE 1961
Cdd:cd12793 169 ----------------------------ERAKAIPEIYLTRLLSMKGTLQKFVDDLFTVILSTSRPVPLAVKYFFDLLDE 220
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1962 QAQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINKLLYAR 2041
Cdd:cd12793 221 QALQHGISDPETIHIWKTNSLPLRFWINIIKNPQFIFDVQTSDNVDAVLSVIAQTFMDSCTIADHKLGRDSPINKLLYAR 300
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 2042 DIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYINKYYDQIITALEEDGTAQKMQLGYR 2121
Cdd:cd12793 301 DIPRYKQMVERYYADIRQTVSASDQEMNSALAELSRNYSGELNYLVALHELYKYINKYYDQIITALEEDSTAQKMQLGYR 380
|
570
....*....|....
gi 767923571 2122 LQQIAAAVENKVTD 2135
Cdd:cd12793 381 LQQIAAAVENKVTD 394
|
|
| Sema |
smart00630 |
semaphorin domain; |
35-454 |
7.84e-82 |
|
semaphorin domain;
Pssm-ID: 214747 [Multi-domain] Cd Length: 390 Bit Score: 275.40 E-value: 7.84e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 35 LQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPdecPQAQPTNNPNQLLLV---SPGALVVC 111
Cdd:smart00630 1 LQHLLLDEDNGTLYVGARNRLYQLSLNLILEAELKTGPVLSSPDCEECVSK---GKDPPTDCVNYIRLLldyNEDRLLVC 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 112 GS-VHQGVCEQRRLGQLeqlllrperpgdtqyvaandpavstvglvaqglagepllFVGRGYTSRGVGGGIPPITTralW 190
Cdd:smart00630 78 GTnAFQPVCRLRNLGEL---------------------------------------YVGTVADFSGSDPAIPRSLS---V 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 191 PPDPQAAFSYEETAKLAVGRLseYSHHFVSAFARGASAYFLFLRR--DLQAQSRAFRAYVSRVCLRD--------QHYYS 260
Cdd:smart00630 116 RRLKGTSGVSLRTVLYDSKWL--NEPNFVYAFESGDFVYFFFRETavEDDNCGKAVHSRVARVCKNDvggprsldKKWTS 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 261 YVELPLACEGG-----RYGLIQAAAVATSREVaHGEVLFAAFSSAAPPTVGrppsaaagasgaSALCAFPLDEVDRLANR 335
Cdd:smart00630 194 FLKARLECSVPgedpfYFNELQAAFLLPPGSE-SDDVLYGVFSTSSNPIPG------------SAVCAFSLSDINAVFNG 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 336 TRDACYTREGRAEDGTEvAYIEYDVNSDCAQLPVDTLDaYPC----GSDHTPSPMASRVPLEATPIL--EWPGIQLTAVA 409
Cdd:smart00630 261 PFKECETSTSQWLPYSR-GKVPYPRPGTCPNKPPSSKD-LPDetlnFIKSHPLMDEVVQPLTGRPLFvkTDSNYLLTSIA 338
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 767923571 410 VTMED---GHTIAFLGDSQGQLHRVYLGPGSDGHP---YSTQSIQQ-GSAVS 454
Cdd:smart00630 339 VDRVAtdgNYTVLFLGTSDGRILKVVLSESSSSSEsvvLEEISVFPdGSPIS 390
|
|
| TIG_2 |
pfam18020 |
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG ... |
921-1020 |
7.38e-34 |
|
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG domains have an Ig-like fold.
Pssm-ID: 465619 Cd Length: 94 Bit Score: 126.24 E-value: 7.38e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 921 GSTLMPVHVEREIRLLGRNLHLFQDGPGDNECVMELEGLEVVVEARVECEPppdtqcHVTCQQHQLSYEALQPELRVGLF 1000
Cdd:pfam18020 1 GSILVPVGVEREITLKARNLPLFQSGQLGYECVFEIEGATHVVPASRESSD------SITCQEHQFSYSGSSGELPATFY 74
|
90 100
....*....|....*....|
gi 767923571 1001 LRRAGRLRVDSAEGLHVVLY 1020
Cdd:pfam18020 75 VTWNGGHRLDNPANLQVVLY 94
|
|
| IPT_plexin_repeat1 |
cd01180 |
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ... |
1070-1161 |
2.52e-33 |
|
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.
Pssm-ID: 238585 Cd Length: 94 Bit Score: 124.74 E-value: 2.52e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1070 PLIHSVEPLTGPVDGGTRVTIRGSNLGQHVQDVLGMVTVAGVPCAVDAQEYEVSSSLVCITGASGEEVaGATAVEVPGRG 1149
Cdd:cd01180 1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNPV-FNGPVEVTVGH 79
|
90
....*....|....*
gi 767923571 1150 ---RGVSEHDFAYQD 1161
Cdd:cd01180 80 gsfRTESSEGFSFVD 94
|
|
| IPT_plexin_repeat3 |
cd01181 |
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ... |
1252-1376 |
4.19e-32 |
|
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.
Pssm-ID: 238586 Cd Length: 99 Bit Score: 121.37 E-value: 4.19e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1252 PNITSAGPTKSFLSGGREICVRGQNLDVVQTPRIRVTVVSRmlqpsqglgrrrrvvpetacslgpscssqqFEEPCHVNS 1331
Cdd:cd01181 1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRVKYGGV------------------------------EKTSCKVRN 50
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 767923571 1332 SQLITCRTPALPGLP---EDPWVRVEFILDNLVF-DFATLNPTPFSYEA 1376
Cdd:cd01181 51 STLMTCPAPSLALLNrspEPGERPVEFGLDGDNVqSLLILNRTSFSYYP 99
|
|
| IPT_plexin_repeat2 |
cd01179 |
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ... |
1162-1249 |
4.36e-27 |
|
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.
Pssm-ID: 238584 Cd Length: 85 Bit Score: 106.54 E-value: 4.36e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1162 PKVHSIFPARGPRAGGTRLTLNGSKLLTGRleDIRVVVGDQPCHLLPeQQSEQLRCETSPRPTPATLPVAVWFGATeRRL 1241
Cdd:cd01179 1 PSITSLSPSYGPQSGGTRLTITGKHLNAGS--SVRVTVGGQPCKILS-VSSSQIVCLTPPSASPGEAPVKVLIDGA-RRL 76
|
....*...
gi 767923571 1242 QRGQFKYT 1249
Cdd:cd01179 77 APLVFTYT 84
|
|
| TIG_plexin |
pfam17960 |
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ... |
541-627 |
1.43e-26 |
|
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.
Pssm-ID: 465588 Cd Length: 89 Bit Score: 105.04 E-value: 1.43e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 541 PANISREETREVFLSVPDLPPLwpGESYSCHFGEH-QSPALLTGSGVMCPSPDPSEAPVLPRGADYVSVSVELRFGA--V 617
Cdd:pfam17960 2 PDNISRTTATQLTLTVPNLPAL--SEGYSCVFGDLtESPATVHDNGVKCATPPPSQLPPIPTGQDHVTVKLSLRSSEtgV 79
|
90
....*....|
gi 767923571 618 VIAKTSLSFY 627
Cdd:pfam17960 80 DFASTNFTFY 89
|
|
| Sema |
pfam01403 |
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ... |
276-460 |
2.20e-17 |
|
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805
Pssm-ID: 460197 [Multi-domain] Cd Length: 180 Bit Score: 81.93 E-value: 2.20e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 276 IQAAAVAT-SREVAHGEVLFAAFSSAAPPTVGRppsaaagasgaSALCAFPLDEVDRLANRtRDACYTREGRAEDGTEVA 354
Cdd:pfam01403 1 LQDVFVLKpGAGDALDTVLYGVFTTQWSNSIGG-----------SAVCAFSLSDINAVFEG-PFKEQEKSDSKWLPYTGK 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 355 yIEYDVNSDCAQLPV--DTLDAYPCGSDHTPSPMASRVPLEATPILEWPGIQLTAVAVTM---EDG-HTIAFLGDSQGQL 428
Cdd:pfam01403 69 -VPYPRPGTCINDPLrlDLPDSVLNFVKDHPLMDEAVQPVGGRPLLVRTGVRLTSIAVDRvqaLDGnYTVLFLGTDDGRL 147
|
170 180 190
....*....|....*....|....*....|...
gi 767923571 429 HRVYLGPGSDGHPYSTQSI-QQGSAVSRDLTFD 460
Cdd:pfam01403 148 HKVVLVGSEESHIIEEIQVfPEPQPVLNLLLSS 180
|
|
| IPT |
smart00429 |
ig-like, plexins, transcription factors; |
1161-1249 |
3.31e-16 |
|
ig-like, plexins, transcription factors;
Pssm-ID: 214657 [Multi-domain] Cd Length: 90 Bit Score: 75.53 E-value: 3.31e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1161 DPKVHSIFPARGPRAGGTRLTLNGSKLLTGRLEDIRVVVGDQPCHLLPEQQSeQLRCETSPRPT-PATLPV-AVWFGATE 1238
Cdd:smart00429 1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEAPCTFSPSSST-AIVCKTPPYHNiPGSVPVrTVGLRNGG 79
|
90
....*....|.
gi 767923571 1239 RRLQRGQFKYT 1249
Cdd:smart00429 80 VPSSPQPFTYV 90
|
|
| PSI |
pfam01437 |
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ... |
481-527 |
1.13e-14 |
|
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).
Pssm-ID: 396154 [Multi-domain] Cd Length: 52 Bit Score: 70.04 E-value: 1.13e-14
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 767923571 481 SCAQHLDCASCLAHRDPYCGWCVLLGRCSRRSECSrGQGPEQWLWSF 527
Cdd:pfam01437 1 RCSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACG-APEGNCEEWEQ 46
|
|
| IPT |
smart00429 |
ig-like, plexins, transcription factors; |
1070-1159 |
7.52e-14 |
|
ig-like, plexins, transcription factors;
Pssm-ID: 214657 [Multi-domain] Cd Length: 90 Bit Score: 68.99 E-value: 7.52e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1070 PLIHSVEPLTGPVDGGTRVTIRGSNLGQhVQDVLGMVTVAGVPCAVDAQEyevSSSLVCITGASGEEVAGATAVEVPGRG 1149
Cdd:smart00429 2 PVITRISPTSGPVSGGTEITLCGKNLKS-ISVVFVEVGVGEAPCTFSPSS---STAIVCKTPPYHNIPGSVPVRTVGLRN 77
|
90
....*....|..
gi 767923571 1150 RGV--SEHDFAY 1159
Cdd:smart00429 78 GGVpsSPQPFTY 89
|
|
| PSI |
smart00423 |
domain found in Plexins, Semaphorins and Integrins; |
482-520 |
3.59e-12 |
|
domain found in Plexins, Semaphorins and Integrins;
Pssm-ID: 214655 [Multi-domain] Cd Length: 47 Bit Score: 62.56 E-value: 3.59e-12
10 20 30
....*....|....*....|....*....|....*....
gi 767923571 482 CAQHLDCASCLAHRDPYCGWCVLLGRCSRRSECSRGQGP 520
Cdd:smart00423 2 CSKYTSCSECLLARDPYCAWCSSQGRCTSGERCDSRRQN 40
|
|
| IPT |
smart00429 |
ig-like, plexins, transcription factors; |
1251-1374 |
1.18e-11 |
|
ig-like, plexins, transcription factors;
Pssm-ID: 214657 [Multi-domain] Cd Length: 90 Bit Score: 62.82 E-value: 1.18e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1251 DPNITSAGPTKSFLSGGREICVRGQNLDVVQTPRIRVTVVsrmlqpsqglgrrrrvvpETACSLGPSCSSQqfeepchvn 1330
Cdd:smart00429 1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVG------------------EAPCTFSPSSSTA--------- 53
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 767923571 1331 ssqlITCRTPALPGLPEDPWVR-VEFILDNLVFDfatlnPTPFSY 1374
Cdd:smart00429 54 ----IVCKTPPYHNIPGSVPVRtVGLRNGGVPSS-----PQPFTY 89
|
|
| TIG |
pfam01833 |
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ... |
1070-1159 |
7.70e-11 |
|
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.
Pssm-ID: 460355 [Multi-domain] Cd Length: 84 Bit Score: 60.15 E-value: 7.70e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1070 PLIHSVEPLTGPVDGGTRVTIRGSNLGQHVQDVlgMVTVAGVPCAVDAQEyevSSSLVCITGASGEEVAGATaVEVPGRG 1149
Cdd:pfam01833 1 PVITSISPSSGPASGGTTITITGSNFGTDSSDL--KVTIGGTPCTVISVS---STTIVCTTPPGTSGLVNVS-VTVGGGG 74
|
90
....*....|
gi 767923571 1150 RGVSEHDFAY 1159
Cdd:pfam01833 75 ISSSPLTFTY 84
|
|
| TIG |
pfam01833 |
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ... |
1162-1248 |
1.42e-10 |
|
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.
Pssm-ID: 460355 [Multi-domain] Cd Length: 84 Bit Score: 59.38 E-value: 1.42e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1162 PKVHSIFPARGPRAGGTRLTLNGSKLLTGRlEDIRVVVGDQPChLLPEQQSEQLRCETSPRpTPATLPVAVWFGATERRL 1241
Cdd:pfam01833 1 PVITSISPSSGPASGGTTITITGSNFGTDS-SDLKVTIGGTPC-TVISVSSTTIVCTTPPG-TSGLVNVSVTVGGGGISS 77
|
....*..
gi 767923571 1242 QRGQFKY 1248
Cdd:pfam01833 78 SPLTFTY 84
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
681-839 |
3.96e-08 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 59.18 E-value: 3.96e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 681 SPDPPARGGPsPSPPTAPKALATPAPDTLPVEPGAPSTATASDISPGASPSLLSPwgpwagsgsiSSPGSTGSPLHEEPS 760
Cdd:PHA03247 2732 SPALPAAPAP-PAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTR----------PAVASLSESRESLPS 2800
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 761 PPSPQNGPGTAVPAPTDFRPSATPEDLLASPLSPSEVAAVPPADPGPEALHP------------TVPLDLPPATVPATTF 828
Cdd:PHA03247 2801 PWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLggsvapggdvrrRPPSRSPAAKPAAPAR 2880
|
170
....*....|.
gi 767923571 829 PGAMGSVKPAL 839
Cdd:PHA03247 2881 PPVRRLARPAV 2891
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
670-837 |
4.70e-07 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 55.16 E-value: 4.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 670 PMVASHQSPLVSPDPPARGGPSPSPPTAPkalaTPAPDTLPVEPGAPSTATASDISPGASPSLLSPWGPWAGSGSISSPG 749
Cdd:pfam03154 171 PPVLQAQSGAASPPSPPPPGTTQAATAGP----TPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPH 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 750 STGSPLHEEPSPP--SPQ-------NGPGTAVPAPTDFRPSATPEDLLAS-------------PLSPSEVAAV------- 800
Cdd:pfam03154 247 PPLQPMTQPPPPSqvSPQplpqpslHGQMPPMPHSLQTGPSHMQHPVPPQpfpltpqssqsqvPPGPSPAAPGqsqqrih 326
|
170 180 190
....*....|....*....|....*....|....*...
gi 767923571 801 -PPADPGPEALHPTVPLDLPPAtvpattfPGAMGSVKP 837
Cdd:pfam03154 327 tPPSQSQLQSQQPPREQPLPPA-------PLSMPHIKP 357
|
|
| PSI |
smart00423 |
domain found in Plexins, Semaphorins and Integrins; |
641-677 |
4.49e-06 |
|
domain found in Plexins, Semaphorins and Integrins;
Pssm-ID: 214655 [Multi-domain] Cd Length: 47 Bit Score: 45.61 E-value: 4.49e-06
10 20 30
....*....|....*....|....*....|....*...
gi 767923571 641 CQACVSSRWG-CNWCVWQHLCTHKASCDAGPMVASHQS 677
Cdd:smart00423 8 CSECLLARDPyCAWCSSQGRCTSGERCDSRRQNWLSGG 45
|
|
| PSI |
pfam01437 |
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ... |
1021-1061 |
2.88e-05 |
|
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).
Pssm-ID: 396154 [Multi-domain] Cd Length: 52 Bit Score: 43.47 E-value: 2.88e-05
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 767923571 1021 DCSvGHGDCSRCQTAmPQYGCVWCEGERpRCVTREACGEAE 1061
Cdd:pfam01437 1 RCS-QYTSCSSCLAA-RDPYCGWCSSEG-RCVRRSACGAPE 38
|
|
| KLF9_13_N-like |
cd21975 |
Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like ... |
680-826 |
5.44e-05 |
|
Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the related N-terminal domains of KLF9, KLF13, KLF14, KLF16, and similar proteins.
Pssm-ID: 409240 [Multi-domain] Cd Length: 163 Bit Score: 45.84 E-value: 5.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 680 VSPDPPARGGPSPSPPTAPKA-LATPAPDTLPVEPGAPSTATASdispGASPSLL--SPWGPWAGSGSISSPGSTGSPLH 756
Cdd:cd21975 21 VRPDPEGAGLAAGLDVRATREvAKGPGPPGPAWKPDGADSPGLV----TAAPHLLaaNVLAPLRGPSVEGSSLESGDADM 96
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 757 EEPSPPSPQngPGTAvpaptdfrPSATPEDLLASPLSPSEVAAVPPADPGPEALHPTVPLDLPPATVPAT 826
Cdd:cd21975 97 GSDSDVAPA--SGAA--------ASTSPESSSDAASSPSPLSLLHPGEAGLEPERPRPRVRRGVRRRGVT 156
|
|
| PSI |
smart00423 |
domain found in Plexins, Semaphorins and Integrins; |
1021-1068 |
6.68e-05 |
|
domain found in Plexins, Semaphorins and Integrins;
Pssm-ID: 214655 [Multi-domain] Cd Length: 47 Bit Score: 42.15 E-value: 6.68e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 767923571 1021 DCSVgHGDCSRCQTAMPQYgCVWCEGERpRCVTREACGE--AEAVATQCP 1068
Cdd:smart00423 1 RCSK-YTSCSECLLARDPY-CAWCSSQG-RCTSGERCDSrrQNWLSGGCP 47
|
|
| PSI |
pfam01437 |
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ... |
641-666 |
3.64e-03 |
|
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).
Pssm-ID: 396154 [Multi-domain] Cd Length: 52 Bit Score: 37.30 E-value: 3.64e-03
10 20
....*....|....*....|....*..
gi 767923571 641 CQACVSSR-WGCNWCVWQHLCTHKASC 666
Cdd:pfam01437 8 CSSCLAARdPYCGWCSSEGRCVRRSAC 34
|
|
| half-pint |
TIGR01645 |
poly-U binding splicing factor, half-pint family; The proteins represented by this model ... |
696-880 |
5.37e-03 |
|
poly-U binding splicing factor, half-pint family; The proteins represented by this model contain three RNA recognition motifs (rrm: pfam00076) and have been characterized as poly-pyrimidine tract binding proteins associated with RNA splicing factors. In the case of PUF60 (GP|6176532), in complex with p54, and in the presence of U2AF, facilitates association of U2 snRNP with pre-mRNA.
Pssm-ID: 130706 [Multi-domain] Cd Length: 612 Bit Score: 41.98 E-value: 5.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 696 TAPKALATPA-PDTLPVEPG---APSTA--TASDISPGAS---PSLLSPWGPWAGSGSISSPGSTGSPLHEEPS--PPSP 764
Cdd:TIGR01645 283 TPPDALLQPAtVSAIPAAAAvaaAAATAkiMAAEAVAGAAvlgPRAQSPATPSSSLPTDIGNKAVVSSAKKEAEevPPLP 362
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 765 QNGPGTAVPAPTDFrPSATPEDLLASPLSPSEVAAVPPADPGPEAL-HPTVPLDLppatvpaTTFPGAMGSVKPALDWLT 843
Cdd:TIGR01645 363 QAAPAVVKPGPMEI-PTPVPPPGLAIPSLVAPPGLVAPTEINPSFLaSPRKKMKR-------EKLPVTFGALDDTLAWKE 434
|
170 180 190
....*....|....*....|....*....|....*..
gi 767923571 844 REGGELPEADEWTGGDAPAFSTSTLLSGDGDSAELEG 880
Cdd:TIGR01645 435 PSKEDQTSEDGKMLAIMGEAAAALALEPKKKKKEKEG 471
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| Plexin_cytopl |
pfam08337 |
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ... |
1562-2098 |
0e+00 |
|
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.
Pssm-ID: 462434 [Multi-domain] Cd Length: 500 Bit Score: 876.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1562 GIPFLDYKVYAERIFFPGHRESPLHRDLGVP---ESRRPTVEQGLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYVA 1638
Cdd:pfam08337 1 GIPFLDYRTYAMRVLFPGVEDHPLLVLLDVPvtnDGRRTNVEQALTQFSQLLNNKLFLLTFIRTLESQRSFSIRDRCNVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1639 SLLTVALHGKLEYFTDILRTLLSDLVAQYV-AKNPKLMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQ 1717
Cdd:pfam08337 81 SLLMVALHGKLEYATEILKTLLRDLIDKSVeSKNPKLLLRRTESVVEKMLTNWMSICLYPFLRECAGEPLFLLYKAIKQQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1718 VDKGPVDSVTGKAKYTLNDNRLLREDVEYRPLTLNALLAVGpgaGEAQGVPVKVLDCDTISQAKEKMLDQLYKGVPLTQR 1797
Cdd:pfam08337 161 VEKGPVDAITGKARYTLSEDKLLREQIDYKTLTLHVIFEEG---ENSESVPVKVLDCDTITQVKEKILDAIYKNTPYSQR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1798 PDPRTLDVEWRSGVAGHLILSDEDVTSEVQGLWRRLNTLQHYKqVPDGATVALVPcltkhvlrenqdyvpgertpmledv 1877
Cdd:pfam08337 238 PSIDEVDLEWRHGRGGRLTLQDEDSTSKVEGGWKKLNTLAHYK-VPDGATLALIP------------------------- 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1878 deggiRPWHLVKPSDEPEPprprrgslRGGERERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILST-SRPVPLAVKYFF 1956
Cdd:pfam08337 292 -----KYWHLVKPSDEGDQ--------RKKSERRKKAIPEIYLTRLLSTKGTLQKFVDDLFESILSVpNSALPLAVKYLF 358
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1957 DLLDEQAQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINK 2036
Cdd:pfam08337 359 DFLDEQAEKHGITDPEVLHIWKSNSLPLRFWVNIIKNPQFVFDINKSPIVDSCLSVIAQTFMDSCSTSEHRLGKDSPSNK 438
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767923571 2037 LLYARDIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYINK 2098
Cdd:pfam08337 439 LLYAKDIPRYKQMVERYYKDISNMPPISDQEMNAFLAEESRKHQNEFNTSAALKELYKYVNK 500
|
|
| Sema_plexin_B1 |
cd11275 |
The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the ... |
28-480 |
0e+00 |
|
The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D-plexin B signaling complex regulates dendritic and axonal complexity. The activation of Plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.
Pssm-ID: 200536 [Multi-domain] Cd Length: 461 Bit Score: 855.80 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 28 FTPNGTYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPDECPQAQPTNNPNQLLLVSPG- 106
Cdd:cd11275 1 FSPNGTKFLHLSMDPESGTLYLGATNFLFQLTPDLLLENMVQTGPVLDSKDCLPPVSKLECPQAQHTNNHNKLLLVNPVq 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 107 -ALVVCGSVHQGVCEQRRLGQLEQLLLRPERPGDTQYVAANDPAVSTVGLVAQGLAGEPLLFVGRGYTSRGVGGGIPPIT 185
Cdd:cd11275 81 kELIVCGSVHQGICEKRRLGSIDHVLFRPERPGDTQYVAANDPNVTTVGLVAYSKDGVPLLFVGRGYTSRGVGGGIPPIT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 186 TRALWPP-----DPQAAFSYEETAKLAVGRLSEYSHHFVSAFARGASAYFLFLRRDLQAQSRAFRAYVSRVCLRDQHYYS 260
Cdd:cd11275 161 TRNLRAHgddatDSHSIFSYEETAKLAVGRLSEYNHHFIKAFTYGSSVYFLFYRRDLKSQSREYKTYISRICLDDSHYYS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 261 YVELPLACEG--GRYGLIQAAAVATSRE-------VAHGEVLFAAFSSAAPPTVGRppsaaagaSGASALCAFPLDEVDR 331
Cdd:cd11275 241 YVELPLLCQSkaNTYSLLQAAYVTQPGErlaqgqlDTDGEVLFAAFSAWQASSGKL--------SEESALCAYPMDEVDR 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 332 LANRTRDACYTREGRAEDGTEVAYIEYDVNSDCAQLPVDTLDAYPCGSDHTPSPMASRVPLEATPILEWPGIQLTAVAVT 411
Cdd:cd11275 313 LTNWTRDVCYTRDGKAEDGTEVAYIEYDVSSNCVQLPADTLDAYPCGSDHTPSPMASRVPLEATPLLEWTEIRLTAVAVN 392
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767923571 412 MEDGHTIAFLGDSQGQLHRVYLGPGSDGHPYSTQSIQQGSAVSRDLTFDGTFEHLYVMTQSTLLKVPVA 480
Cdd:cd11275 393 VEDGHTIAFLGDSRGRLHKVYLGAGGDAHTYSSQSIQQNSAVSGDLLFDQLQEHLYVMTQSTVLKVPIA 461
|
|
| RasGAP_plexin_B1 |
cd12793 |
Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane ... |
1562-2135 |
0e+00 |
|
Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D and plexin-B1 signaling complex regulates dendritic and axonal complexity. The activation of Plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin-B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin-B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin-B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.
Pssm-ID: 213353 [Multi-domain] Cd Length: 394 Bit Score: 788.46 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1562 GIPFLDYKVYAERIFFPGHRESPLHRDLGVPESRRPTVEQGLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYVASLL 1641
Cdd:cd12793 1 GIPFLDYRMYAERIFFPGHRESPLRRDLDVPECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLESQRTFSPRDRAYVASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1642 TVALHGKLEYFTDILRTLLSDLVAQYVAKNPKLMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQVDKG 1721
Cdd:cd12793 81 TVALHGKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTETVVEKLLTNWMSICLYTFLRDSAGESLYMLFRAIKHQVDKG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1722 PVDSVTGKakytlndnrllredveyrpltlnallavgpgageaqgvpvkvldcdtisqakekmldqlykgvpltqrpdpr 1801
Cdd:cd12793 161 PVDAVTGK------------------------------------------------------------------------ 168
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1802 tldvewrsgvaghlilsdedvtsevqglwrrlntlqhykqvpdgatvalvpcltkhvlrenqdyvpgertpmledvdegg 1881
Cdd:cd12793 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1882 irpwhlvkpsdepepprprrgslrggerERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTSRPVPLAVKYFFDLLDE 1961
Cdd:cd12793 169 ----------------------------ERAKAIPEIYLTRLLSMKGTLQKFVDDLFTVILSTSRPVPLAVKYFFDLLDE 220
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1962 QAQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINKLLYAR 2041
Cdd:cd12793 221 QALQHGISDPETIHIWKTNSLPLRFWINIIKNPQFIFDVQTSDNVDAVLSVIAQTFMDSCTIADHKLGRDSPINKLLYAR 300
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 2042 DIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYINKYYDQIITALEEDGTAQKMQLGYR 2121
Cdd:cd12793 301 DIPRYKQMVERYYADIRQTVSASDQEMNSALAELSRNYSGELNYLVALHELYKYINKYYDQIITALEEDSTAQKMQLGYR 380
|
570
....*....|....
gi 767923571 2122 LQQIAAAVENKVTD 2135
Cdd:cd12793 381 LQQIAAAVENKVTD 394
|
|
| RasGAP_plexin_B |
cd12787 |
Ras-GTPase Activating Domain of type B plexins; Plexins form a conserved family of ... |
1562-2131 |
0e+00 |
|
Ras-GTPase Activating Domain of type B plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity.There are three members of the Plexin-B subfamily, namely B1, B2 and B3. Plexins-B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin-B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin-B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin-B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin-B signaling. Plexin-B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin-B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.
Pssm-ID: 213347 [Multi-domain] Cd Length: 391 Bit Score: 755.61 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1562 GIPFLDYKVYAERIFFPGHRESPLHRD--LGVPESRRPTVEQGLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYVAS 1639
Cdd:cd12787 1 GIPFLDYKTYAERVFFPGHKDGPLDVMikLDIPEPRRPTVEQGLYQLSNLLNSKLFLINFIHTLENQREFSARDRVYVAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1640 LLTVALHGKLEYFTDILRTLLSDLVAQYVAKNPKLMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQVD 1719
Cdd:cd12787 81 LLTVALHGKLEYYTDIMRTLLLDLLAQYVVKNPKLMLRRTETVVEKLLTNWMSICLYQFLRDSAGEPLYMLFRAIKHQVD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1720 KGPVDSVTGKakytlndnrllredveyrpltlnallavgpgageaqgvpvkvldcdtisqakekmldqlykgvpltqrpd 1799
Cdd:cd12787 161 KGPVDAVTGK---------------------------------------------------------------------- 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1800 prtldvewrsgvaghlilsdedvtsevqglwrrlntlqhykqvpdgatvalvpcltkhvlrenqdyvpgertpmledvde 1879
Cdd:cd12787 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1880 ggirpwhlvkpsdepepprprrgslrggereRAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTSRPVPLAVKYFFDLL 1959
Cdd:cd12787 171 -------------------------------RAKAIPEIYLTRLLSMKGTLQKFVDDFFQSILSPGRPVPPAVKYFFDLL 219
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1960 DEQAQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINKLLY 2039
Cdd:cd12787 220 DEQAEKHGIQDEDTIHIWKTNSLPLRFWVNILKNPQFIFDVHVSDNVDASLSVIAQTFMDACTRTEHKLGRDSPSNKLLY 299
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 2040 ARDIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYINKYYDQIITALEEDGTAQKMQLG 2119
Cdd:cd12787 300 AREIPRYKKMVERYYADIRQMVPASDQEMNSHLAELSRNYTDSLNTLVALHELYQYIQKYYDQIINALEEDPAAQKMQLA 379
|
570
....*....|..
gi 767923571 2120 YRLQQIAAAVEN 2131
Cdd:cd12787 380 FRLQQIAAAVEN 391
|
|
| Sema_plexin_B |
cd11245 |
The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin ... |
34-480 |
0e+00 |
|
The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin domains, function as receptors of semaphorins and may be the ancestors of semaphorins. There are three members of the Plexin B subfamily, namely B1, B2 and B3. Plexins B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin B signaling. Plexin B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.
Pssm-ID: 200506 [Multi-domain] Cd Length: 440 Bit Score: 752.92 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 34 YLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPDECPQAQPTNNPNQLLLVSP--GALVVC 111
Cdd:cd11245 1 IINHLAQDPQTGRLYLGAVNGLFQLSPNLQLESRADTGPKKDSPQCLPPITAAECPQAKETDNFNKLLLVNSanGTLVVC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 112 GSVHQGVCEQRRLGQLEQLLLRPERPGDTQYVAANDPAVSTVGLVAQGLAGEPLLFVGRGYTSRGvGGGIPPITTRALWP 191
Cdd:cd11245 81 GSLFQGVCELRNLNSVNKPLYRPETPGDKQYVAANEPSVSTVGLISYFKDGLSLLFVGRGYTSSL-SGGIPPITTRLLQE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 192 PDPQAAFSYEETAKLAVGRLSEYSHHFVSAFARGASAYFLFLRRDLQAQsRAFRAYVSRVCLRDQHYYSYVELPLACE-- 269
Cdd:cd11245 160 HGEMDAFSNEVEAKLVVGSASRYHHDFVYAFADNGYIYFLFSRRPGTAD-STKRTYISRLCENDHHYYSYVELPLNCTvn 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 270 -GGRYGLIQAAAVATSREVAHGEVLFAAFSSAAPPTVGrppsaaagASGASALCAFPLDEVDRLANRTRDACYTREGRAE 348
Cdd:cd11245 239 qENTYNLVQAAYLAKPGKVLNGKVLFGVFSADEASTAA--------PDGRSALCMYPLSSVDARFERTRESCYTGEGLED 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 349 DGTEVAYIEYDVNSDCAQLPVDTLDAYPCGSDHTPSPMASRVPLEATPILEWPgIQLTAVAVTMEDGHTIAFLGDSQGQL 428
Cdd:cd11245 311 DKPETAYIEYNVKSICKTLPDKNVKAYPCGAEHTPSPLASRYPLAAKPILTRN-DMLTAVAVAVENGHTIAFLGDSGGQL 389
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 767923571 429 HRVYLGPGsDGHPYSTQSIQQGSAVSRDLTFDGTFEHLYVMTQSTLLKVPVA 480
Cdd:cd11245 390 HKVYLDPN-HTDFYSTIPGDQDSAVNKDLLFDSTLNHLYVMTGKKISKVPVQ 440
|
|
| RasGAP_plexin_B3 |
cd12791 |
Ras-GTPase Activating Domain of plexin-B3; Plexins form a conserved family of transmembrane ... |
1562-2135 |
0e+00 |
|
Ras-GTPase Activating Domain of plexin-B3; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin-B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin-B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The protein and mRNA expression of Sema5A and its receptor plexin-B3 increased gradually in non-neoplastic mucosa, primary gastric carcinoma, and lymph node metastasis, and their expression is correlated. The stimulation of plexin-B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.
Pssm-ID: 213351 [Multi-domain] Cd Length: 397 Bit Score: 681.95 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1562 GIPFLDYKVYAERIFFPGHRESPLHR--DLGVPESRRPTVEQGLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYVAS 1639
Cdd:cd12791 1 GIPFLDYRTYAERVFFPGHGGCPLQPslEGDGEEGRRATVEQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1640 LLTVALHGKLEYFTDILRTLLSDLVAQYVAKNPKLMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQVD 1719
Cdd:cd12791 81 LLSLALHGKLEYLTDIMKTLLGDLAAHYVHKNPKLMLRRTETMVEKLLTNWMSICLYAFLREVAGEPLYMLFRAIKYQVD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1720 KGPVDSVTGKakytlndnrllredveyrpltlnallavgpgageaqgvpvkvldcdtisqakekmldqlykgvpltqrpd 1799
Cdd:cd12791 161 KGPVDAVTGK---------------------------------------------------------------------- 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1800 prtldvewrsgvaghlilsdedvtsevqglwrrlntlqhykqvpdgatvalvpcltkhvlrenqdyvpgertpmledvde 1879
Cdd:cd12791 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1880 ggirpwhlvkpsdepepprprrgslrggeRERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTSRPVPLAVKYFFDLL 1959
Cdd:cd12791 171 -----------------------------RERAKAIPEIYLTRLLSMKGTLQKFVDDTFQAILSVNRPVPIAVKYLFDFL 221
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1960 DEQAQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINKLLY 2039
Cdd:cd12791 222 DELAEKHGIEDPETLHIWKTNSLLLRFWVNTLKNPQFIFDVRVSDNVDAILAVIAQTFIDSCTISEHKVGRDSPVNKLLY 301
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 2040 ARDIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYINKYYDQIITALEEDGTAQKMQLG 2119
Cdd:cd12791 302 AREIPRYKQMVEKYYADIRQSSPASYQEMNSALTELSGNYTSAPHCLVALQELYNHIHRYYDQIISALEEDPVGQKMQLA 381
|
570
....*....|....*.
gi 767923571 2120 YRLQQIAAAVENKVTD 2135
Cdd:cd12791 382 CRLQQIAALVENKVTD 397
|
|
| RasGAP_plexin |
cd12205 |
Ras-GTPase Activating Domain of plexins; Plexins form a conserved family of transmembrane ... |
1562-2127 |
0e+00 |
|
Ras-GTPase Activating Domain of plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes, including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Other proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.
Pssm-ID: 213344 [Multi-domain] Cd Length: 382 Bit Score: 577.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1562 GIPFLDYKVYAERIFFPGHRESPLHRDLGVPESRRPTVEQGLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYVASLL 1641
Cdd:cd12205 1 GIPFLDFREYIIRVLFPGVNDHPVLLSKFVHGSRRPDLEDALSQFEQLLCNKQFLLTFIRTLESQPKFSSRDKCNVASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1642 TVALHGKLEYFTDILRTLLSDLVAQYVAK-NPKLMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQVDK 1720
Cdd:cd12205 81 MVALQGKMEYATEILFDLLTDLIEKSVSKkHPKLMLRRTESVVEKLLTNWLSLCLYDYLKETAGEPLFLLYKALKQQIEK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1721 GPVDSVtgkakytlndnrllredveyrpltlnallavgpgageaqgvpvkvldcdtisqakekmldqlykgvpltqrpdp 1800
Cdd:cd12205 161 GPVDAI-------------------------------------------------------------------------- 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1801 rtldvewrsgvaghlilsdedvtsevqglwrrlntlqhykqvpdgatvalvpcltkhvlrenqdyvpgertpmledvdeg 1880
Cdd:cd12205 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1881 girpwhlvkpsdepepprprrgslrggereraKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTS-RPVPLAVKYFFDLL 1959
Cdd:cd12205 167 --------------------------------KLIPEIFLTRLLSTKGTLQKFVDDLFESILSVPqRSLPPAIKYLFDFL 214
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1960 DEQAQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINKLLY 2039
Cdd:cd12205 215 DEQARKHGISDPDVLHAWKTNSLPLRFWVNIIKNPDFVFDVNKTPTVDSCLSVIAQTFMDACSTSEHKLGKDSPSNKLLF 294
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 2040 ARDIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYINKYYDQIITALEEDGTAQKMQLG 2119
Cdd:cd12205 295 AKDIPRYREMVANFYRDISNLPPVSDEEMNSYLAELSESHSGEFNTNVALSELYIYAVKYGDQLLEALEDDREARVQQLA 374
|
....*...
gi 767923571 2120 YRLQQIAA 2127
Cdd:cd12205 375 DKLSQVAR 382
|
|
| RasGAP_plexin_B2 |
cd12792 |
Ras-GTPase Activating Domain of plexin-B2; Plexins form a conserved family of transmembrane ... |
1562-2135 |
0e+00 |
|
Ras-GTPase Activating Domain of plexin-B2; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin-B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Mice lacking Plexin-B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C and Plexin-B2 signaling modulates ureteric branching. Plexin-B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin-B2 results in renal hypoplasia and occasional double ureters. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.
Pssm-ID: 213352 [Multi-domain] Cd Length: 400 Bit Score: 559.24 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1562 GIPFLDYKVYAERIFF----PGHRESPLHRDLGVPESRRPTVEQGLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYV 1637
Cdd:cd12792 1 RIPFLDYKTYTDRVFFlpskDGANDVMITGKLDIPEARRATVEQALNQFSNLLNSKTFLINFIHTLENQRDFNARAKVYF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1638 ASLLTVALHGKLEYFTDILRTLLSDLVAQYV-AKNPKLMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKH 1716
Cdd:cd12792 81 ASLLTVALHGKLEYYTDIMRTLLLELMEQYVhSKNPKLMLRRSETVVERMLSNWMSICLYQYLKDTAGEPLYKLFKAIKH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1717 QVDKGPVDSVTGKakytlndnrllredveyrpltlnallavgpgageaqgvpvkvldcdtisqakekmldqlykgvpltq 1796
Cdd:cd12792 161 QVEKGPVDAVQKK------------------------------------------------------------------- 173
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1797 rpdprtldvewrsgvaghlilsdedvtsevqglwrrlntlqhykqvpdgatvalvpcltkhvlrenqdyvpgertpmled 1876
Cdd:cd12792 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1877 vdeggirpwhlvkpsdepepprprrgslrggeRERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTSRPVPLAVKYFF 1956
Cdd:cd12792 174 --------------------------------KERTKAITEIYLTRLLSVKGTLQQFVDNFFRSVLCSGAVVPPAVKYFF 221
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1957 DLLDEQAQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINK 2036
Cdd:cd12792 222 DFLDEQAEKHDIVDEETIHIWKTNSLPLRFWVNILKNPHFIFDVHVTEVVDASLSVIAQTFMDACTKTEHKLSRDSPSNK 301
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 2037 LLYARDIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYINKYYDQIITALEEDGTAQKM 2116
Cdd:cd12792 302 LLYAKEISTYKKMVDDYYKGIRQMVPVSDQDMNTHLAEISRAHTDKLNTQVALHQLYQYASKYYDEIINSLEEDPAAQSK 381
|
570
....*....|....*....
gi 767923571 2117 QLGYRLQQIAAAVENKVTD 2135
Cdd:cd12792 382 QLTLRLQQIAAALENKVTD 400
|
|
| Sema_plexin_B3 |
cd11277 |
The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of ... |
28-480 |
7.77e-168 |
|
The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The stimulation of plexin B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.
Pssm-ID: 200538 [Multi-domain] Cd Length: 434 Bit Score: 521.29 E-value: 7.77e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 28 FTPNGTYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPDECPQAQPTNNPNQLLLVS--P 105
Cdd:cd11277 1 FSAPNATFNHLALDPGSGTLYVGAVNRLYQLSPDLQLLGEAVTGPVLDSPDCLPFRDPADCPQARLTDNANKLLLVSerA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 106 GALVVCGSVHQGVCEQRRLGQLEQLLLRPERPGDTQYVAANDPAVSTVGLVAQgLAGEPLLFVGRGYTSRGvGGGIPPIT 185
Cdd:cd11277 81 GELVACGQVRQGVCEKRRLGNVAQVLYQAEDPGDGQFVAANDPGVATVGLVVE-APGRDLLLVGRGLTGKL-SAGIPPLT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 186 TRALWPPDPqaaFSYEETAKLAVGRLSEYSHHFVSAFARGASAYFLFLRRDLQAQsRAFRAYVSRVCLRDQHYYSYVELP 265
Cdd:cd11277 159 IRQLAGAQA---FSSEGLGKLVVGDFSDYNNSYVGAFAHNGYVYFLFRRRGARAQ-AEYRTYVARVCLGDTNLYSYVEVP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 266 LACEGGrYGLIQAAAVATsrevaHGEVLFAAFSSAAPPTvgrppsaaAGASGASALCAFPLDEVDRLANRTRDACYTREG 345
Cdd:cd11277 235 LVCQGG-YNLAQAAYLAP-----GQGTLFVVFAAGQGST--------PTPTDQTALCAYPLVELDSAMERARRLCYTAGG 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 346 RAEDGTEVAYIEYDVNSDCAQLPVDTLDAYPCGSDHTPSPMASRVPLEATPILEWpGIQLTAVAVTMEDGHTIAFLGDSQ 425
Cdd:cd11277 301 GGPNGKEEATIEYGVTSRCVNLPKDSPESYPCGDEHTPSPIASRQPLEAEPLLTL-TPPLTAVAALQEDGHTIAFLGDTQ 379
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 767923571 426 GQLHRVYLGpGSDGHPYSTQSI-QQGSAVSRDLTFDGTFEHLYVMTQSTLLKVPVA 480
Cdd:cd11277 380 GQLHKVFLN-GSAGQVYSSQPVgPPGSAVNPDLLLDATGSHLYVLTARQVTKVPVA 434
|
|
| RasGAP_plexin_A |
cd12790 |
Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of ... |
1562-2125 |
1.62e-159 |
|
Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. They are divided into four types (A-D) according to sequence similarity. In vertebrates, there are four type A plexins (A1-A4) that serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin-D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 1 and class 6 semaphorins signal through type A plexins, which mediate diverse biological functions including axon guidance, cardiovascular development, and immune function. Guanylyl cyclase Gyc76C and Off-track kinase (OTK), a putative receptor tyrosine kinase, modulate Sema1a and Plexin-A mediated axon repulsion. In their complex with Sema6s, type A plexins serve as signal-transducing subunits. An increasing number of molecules that interact with the intracellular region of Plexin-A have been identified; among them are IgCAMs (in axon guidance events) and Trem2-DAP12 (in immune responses). Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.
Pssm-ID: 213350 [Multi-domain] Cd Length: 385 Bit Score: 496.18 E-value: 1.62e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1562 GIPFLDYKVYAERIFFPGHRESPLHRDLGVPESRRPTVEQGLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYVASLL 1641
Cdd:cd12790 1 GIPFLDYRTYAMRVLFPGIEDHPVLRELEVERDRQENVEKGLRLFGQLLMNKTFLLTFIRTLESQRSFSMRDRGNVASLI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1642 TVALHGKLEYFTDILRTLLSDLVAQYVAK--NPKLMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQVD 1719
Cdd:cd12790 81 MVVLQSKMEYATDILKQLLADLIEKNLESknHPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFMLFCAIKQQME 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1720 KGPVDSVtgkakytlndnrllredveyrpltlnallavgpgageaqgvpvkvldcdtisqakekmldqlykgvpltqrpd 1799
Cdd:cd12790 161 KGPIDAI------------------------------------------------------------------------- 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1800 prtldvewrsgvaghlilsdedvtsevqglwrrlntlqhykqvpdgatvalvpcltkhvlrenqdyvpgertpmledvde 1879
Cdd:cd12790 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1880 ggirpwhlvkpsdepepprprrgslrggereraKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTSR---PVPLAVKYFF 1956
Cdd:cd12790 168 ---------------------------------KMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHrgsALPLAIKYMF 214
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1957 DLLDEQAQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINK 2036
Cdd:cd12790 215 DFLDEQADQHGITDPEVVHTWKSNCLPLRFWVNLIKNPQFVFDIHKSSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNK 294
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 2037 LLYARDIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYINKYYDQIITALEEDGTAQKM 2116
Cdd:cd12790 295 LLYAKDIPNYKSWVERYYADIAKMPAISDQDMNAYLAEQSRLHLNEFNTLSALNELYSYVTKYKEEILTALEEDEFARKQ 374
|
....*....
gi 767923571 2117 QLGYRLQQI 2125
Cdd:cd12790 375 RLAYKLEQV 383
|
|
| RasGAP_plexin_D1 |
cd12788 |
Ras-GTPase Activating Domain of plexin-D1; Plexins form a conserved family of transmembrane ... |
1562-2133 |
7.81e-143 |
|
Ras-GTPase Activating Domain of plexin-D1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-D1 has been identified as the receptor of Sema3E. It binds to Sema3E directly with high affinity. Sema3E is implicated in axonal path finding and inhibition of developmental and postischemic angiogenesis. Plexin-D1 is broadly expressed on tumor vessels and tumor cells in a number of different types of human tumors. The Plexin-D1 and Sema3E interaction inhibits tumor growth but promotes invasiveness and metastasis. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.
Pssm-ID: 213348 [Multi-domain] Cd Length: 419 Bit Score: 451.37 E-value: 7.81e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1562 GIPFLDYKVYAERIFFP-----------------------GHRES-PLHRDLGVPESRRPTVEQGLGQLSNLLNSKLFLT 1617
Cdd:cd12788 2 GIPFLEYKHFVTRTFFPkcsslyeeryvlpsqennsqgprQVPEThPLLQEWKIPESCRPNMEEGITLFSTLLNNKHFLV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1618 KFIHTLESQRTFSARDRAYVASLLTVALHGKLEYFTDILRTLLSDLVAQYVAKNPKLMLRRTETVVEKLLTNWMSICLYT 1697
Cdd:cd12788 82 TFVHALEQQKDFAVRDRCNLASLLTIALHGKLEYYTSIMKDLLVDLIDASASKNPKLMLRRTESVVEKMLTNWMSICMYS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1698 FVRDSVGEPLYMLFRGIKHQVDKGPVDSVTgkakytlndnrllredveyrpltlnallavgpgageaqgvpvkvldcdti 1777
Cdd:cd12788 162 YLRETVGEPFFLLLCAIKQQINKGSIDAIK-------------------------------------------------- 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1778 sqakekmldqlykgvpltqrpdprtldvewrsgvaghlilsdedvtsevqglwrrlntlqhykqvpdgatvalvpcltkh 1857
Cdd:cd12788 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1858 vlrenqdyvpgertpmledvdeggirpwhlvkpsdepepprprrgslrggereraKAIPEIYLTRLLSMKGTLQKFVDDL 1937
Cdd:cd12788 192 -------------------------------------------------------KVLPEIYLTRLLSTKGTLQKFLDDL 216
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1938 FQVILST--SRPvPLAVKYFFDLLDEQAQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQ 2015
Cdd:cd12788 217 FQAILSIpeDRP-PLAVKYFFDFLEEQAEKRGITDPDTLHIWKTNSLPLRFWVNILKNPQFVFDIDKTDHMDACLSVIAQ 295
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 2016 TFMDACTLADHKLGRDSPINKLLYARDIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKY 2095
Cdd:cd12788 296 AFIDACSISDLQLGKDSPTNKLLYAKEIPEYRKIVQRYYQQIQEMPPLSEQEMNAHLAEESRKYRNEFNTNVAMAEIYKY 375
|
570 580 590
....*....|....*....|....*....|....*...
gi 767923571 2096 INKYYDQIITALEEDGTAQKMQLGYRLQQIAAAVENKV 2133
Cdd:cd12788 376 AKRYRAQIVSALESNPTARRTQLQHKFEQVIALMEDNI 413
|
|
| Sema_plexin_like |
cd11236 |
The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine ... |
34-480 |
3.95e-124 |
|
The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine kinases; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestor of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signalling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. This family also includes the Met and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.
Pssm-ID: 200497 [Multi-domain] Cd Length: 401 Bit Score: 397.47 E-value: 3.95e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 34 YLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPDECPQAQPTNNPNQLLLVSPGA--LVVC 111
Cdd:cd11236 1 PFNHLAVDNSTGRVYVGAVNRLYQLDSSLLLEAEVSTGPVLDSPLCLPPGCCSCDHPRSPTDNYNKILLIDYSSgrLITC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 112 GSVHQGVCEQRRLGQLEQLLLRperpgDTQYVAANDPAVSTVGLVAQG-LAGEPLLFVGRGYTSRGVGGGIPPITTRALW 190
Cdd:cd11236 81 GSLYQGVCQLRNLSNISVVVER-----SSTPVAANDPNASTVGFVGPGpYNNENVLYVGATYTNNGYRDYRPAVSSRSLP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 191 PPDPQAAFSYEETAKLAVGRLS--EYSHHFVSAFARGASAYFLFLRRDLQAQSRAFRAYVSRVCLRDQHYYSYVELPLAC 268
Cdd:cd11236 156 PDDDFNAGSLTGGSAISIDDEYrdRYSIKYVYGFSSGGFSYFVTVQRKSVDDESPYISRLVRVCQSDSNYYSYTEVPLQC 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 269 EGG---RYGLIQAAAVATSREV--------AHGEVLFAAFSSAAPPTVGRPpsaaagasGASALCAFPLDEVDRLANRTr 337
Cdd:cd11236 236 TGGdgtNYNLLQAAYVGKAGSDlarslgisTDDDVLFGVFSKSKGPSAEPS--------SKSALCVFSMKDIEAAFNDN- 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 338 dacytregraedgtevayieydvnsdcaqlpvdtldaypcgsdhtpSPMASRVPLEATPILewPGIQLTAVAVTMEDGHT 417
Cdd:cd11236 307 ----------------------------------------------CPLGGGVPITTSAVL--SDSLLTSVAVTTTRNHT 338
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767923571 418 IAFLGDSQGQLHRVYLGPGSDGHPYSTQSIQQGSAVSRDLTFDGTFEHLYVMTQSTLLKVPVA 480
Cdd:cd11236 339 VAFLGTSDGQLKKVVLESSSSATQYETLLVDSGSPILPDMVFDPDGEHLYVMTPKKVTKVPVE 401
|
|
| RasGAP_plexin_C1 |
cd12789 |
Ras-GTPase Activating Domain of plexin-C1; Plexins form a conserved family of transmembrane ... |
1563-2132 |
3.87e-115 |
|
Ras-GTPase Activating Domain of plexin-C1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-C1 has been identified as the receptor of semaphorin 7A, which plays regulatory roles in both the immune and nervous systems. Unlike other semaphorins which act as repulsive guidance cues, Sema7A enhances central and peripheral axon growth and is required for proper axon tract formation during embryonic development. Plexin-C1 is a potential tumor suppressor for melanoma progression. The expression of Plexin-C1 is diminished or absent in human melanoma cell lines. Cofilin, an actin-binding protein involved in cell migration, is a downstream target of Sema7A and Plexin-C1 signaling. Melanoma invasion and metastasis may be promoted through the loss of Plexin-C1 inhibitory signaling on cofilin activation. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.
Pssm-ID: 213349 [Multi-domain] Cd Length: 393 Bit Score: 371.50 E-value: 3.87e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1563 IPFLDYKVYAERIFFPGHRESPLHRDLGVPESRRPT-VEQGLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYVASLL 1641
Cdd:cd12789 4 VPFLDYKHFALRTFFPESGGFTHIFTRDDPHDRDQTdKDESLTALDKLICNKSFLVTLIHTLEKQKNFSVKDRCLFASFL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1642 TVALHGKLEYFTDILRTLLSDLVAQYVAKNPKLMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQVDKG 1721
Cdd:cd12789 84 TIALQTKLVYLTEILEVLTKDLMDQSSNAQPKLLLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTLNQKINKG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1722 PVDSVTGKAKytlndnrllredveyrpltlnallavgpgageaqgvpvkvldcdtisqakekmldqlykgvpltqrpdpr 1801
Cdd:cd12789 164 PVDVIKFKVK---------------------------------------------------------------------- 173
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1802 tldvewrsgvaghlilsdedvtsevqglwrrlntlqhykqvpdgatvalvpcltkhvlrenqdyvpgertpmledvdegg 1881
Cdd:cd12789 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1882 irpwhlvkpsdepepprprrgslrggererakaipEIYLTRLLSMKGTLQKFVDDLFQVI--LSTSRPvPLAVKYFFDLL 1959
Cdd:cd12789 174 -----------------------------------EMYLTKLLSTKVAIHSVVEKLFRSIwsLPNNKA-PVAIKYFFDFL 217
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1960 DEQAQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINKLLY 2039
Cdd:cd12789 218 DAQAENKKITDPDVLHIWKTNSLPLRFWVNILKNPQFVFDIKKTPHLDGCLSVIAQAFMDSFSLSEQHLGKEAPTNKLLY 297
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 2040 ARDIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYINKYYDQIITALE-EDGTAQKMQl 2118
Cdd:cd12789 298 AKDIPQYKEEVKSYYKAIRDLPPLSSSELEEFLTQESKKHENEFNEEVALMEIYKYIVKYFDEILNKLErERGLEEVQK- 376
|
570
....*....|....
gi 767923571 2119 gyRLQQIAAAVENK 2132
Cdd:cd12789 377 --QLLHVKALFDEK 388
|
|
| Sema_plexin_B2 |
cd11276 |
The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor ... |
33-479 |
1.89e-106 |
|
The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor plays important roles in neural tube closure and cerebellar granule cell development. Mice lacking Plexin B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C-Plexin B2 signaling modulates ureteric branching. Plexin B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin B2 results in renal hypoplasia and occasional double ureters. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.
Pssm-ID: 200537 [Multi-domain] Cd Length: 449 Bit Score: 348.69 E-value: 1.89e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 33 TYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPDECPQAQPTNNPNQLLLVSP--GALVV 110
Cdd:cd11276 6 TELNHLVVDPQTGRVYLGAVNALYQLDADLQLESRVETGPKKDNKKCTPPIEENQCTEAKMTDNYNKLLLLDSanKTLVV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 111 CGSVHQGVCEQRRLGQLEQLLLRPERPGDTQYVAANDPAVSTVGLVAQ-GLAGEPLLFVGRGYTSRGVGggiPPITTRAL 189
Cdd:cd11276 86 CGSLFKGICSLRNLSNISEVIYYSDTSGEKSFVASNDEGVSTVGLISSlKPGNDRVFFVGKGNGSNDNG---KIISTRLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 190 WPPDPQAAF-SYEETAKLAVGRLSEYSHHFVSAFARGASAYFLFLRRDlqAQSRAFRAYVSRVCLRDQHYYSYVELPLAC 268
Cdd:cd11276 163 QNYDDREVFeNYIDAATVKSAYVSRYTQQFRYAFEDNNYVYFLFNQQL--GHPDKNRTLIARLCENDHHYYSYTEMDLNC 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 269 --EGGRYGLIQAAAVATSREV---------AHGEVLFAAFSSAAPPTVGrppsaaagasgaSALCAFPLDEVDRLANRTR 337
Cdd:cd11276 241 rdGANAYNKCQAAYVSTPGKElaqnygnsiLSDKVLFAVFSRDEKDSGE------------SALCMFPLKSINAKMEANR 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 338 DACYTREgraEDGTEVAYIEY--DVNSDCAQLPVDTLDAYPCGSDHTPSPMASRVPL-EATPILEWPGIQLTAVAVTMED 414
Cdd:cd11276 309 EACYTGT---IDDRDVFYKPFhsQKDIICGSHQQKNSKSFPCGSEHLPYPLGSRDELaLTAPVLQRGGLNLTAVTVAVEN 385
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767923571 415 GHTIAFLGDSQGQLHRVYLGPGSDghPYSTQSIQQGSAVSRDLTFDGTFEHLYVMTQSTLLKVPV 479
Cdd:cd11276 386 GHTVAFLGTSDGRILKVHLSPDPE--EYNSILIEKNKPVNKDLVLDKTLEHLYIMTEDKVFRLPV 448
|
|
| Sema |
smart00630 |
semaphorin domain; |
35-454 |
7.84e-82 |
|
semaphorin domain;
Pssm-ID: 214747 [Multi-domain] Cd Length: 390 Bit Score: 275.40 E-value: 7.84e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 35 LQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPdecPQAQPTNNPNQLLLV---SPGALVVC 111
Cdd:smart00630 1 LQHLLLDEDNGTLYVGARNRLYQLSLNLILEAELKTGPVLSSPDCEECVSK---GKDPPTDCVNYIRLLldyNEDRLLVC 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 112 GS-VHQGVCEQRRLGQLeqlllrperpgdtqyvaandpavstvglvaqglagepllFVGRGYTSRGVGGGIPPITTralW 190
Cdd:smart00630 78 GTnAFQPVCRLRNLGEL---------------------------------------YVGTVADFSGSDPAIPRSLS---V 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 191 PPDPQAAFSYEETAKLAVGRLseYSHHFVSAFARGASAYFLFLRR--DLQAQSRAFRAYVSRVCLRD--------QHYYS 260
Cdd:smart00630 116 RRLKGTSGVSLRTVLYDSKWL--NEPNFVYAFESGDFVYFFFRETavEDDNCGKAVHSRVARVCKNDvggprsldKKWTS 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 261 YVELPLACEGG-----RYGLIQAAAVATSREVaHGEVLFAAFSSAAPPTVGrppsaaagasgaSALCAFPLDEVDRLANR 335
Cdd:smart00630 194 FLKARLECSVPgedpfYFNELQAAFLLPPGSE-SDDVLYGVFSTSSNPIPG------------SAVCAFSLSDINAVFNG 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 336 TRDACYTREGRAEDGTEvAYIEYDVNSDCAQLPVDTLDaYPC----GSDHTPSPMASRVPLEATPIL--EWPGIQLTAVA 409
Cdd:smart00630 261 PFKECETSTSQWLPYSR-GKVPYPRPGTCPNKPPSSKD-LPDetlnFIKSHPLMDEVVQPLTGRPLFvkTDSNYLLTSIA 338
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 767923571 410 VTMED---GHTIAFLGDSQGQLHRVYLGPGSDGHP---YSTQSIQQ-GSAVS 454
Cdd:smart00630 339 VDRVAtdgNYTVLFLGTSDGRILKVVLSESSSSSEsvvLEEISVFPdGSPIS 390
|
|
| Sema_plexin_A2 |
cd11272 |
The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor ... |
35-520 |
1.72e-64 |
|
The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor for class 6 semaphorins. Interactions between Plexin A2, A4 and semaphorins 6A and 6B control the lamina-restricted projection of hippocampal mossy fibers. Sema6B also repels the growth of mossy fibers in a Plexin A4 dependent manner. Plexin A2 does not suppress Sema6B function. In addition, studies have shown that Plexin A2 may be related to anxiety and other psychiatric disorders. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.
Pssm-ID: 200533 [Multi-domain] Cd Length: 515 Bit Score: 229.43 E-value: 1.72e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 35 LQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPDECPQAQP-TNNPNQLLLV--SPGALVVC 111
Cdd:cd11272 13 FNHLTVHQSTGAVYVGAINRVYKLSGNLTILVAHKTGPEEDNKSCYPPLIVQPCSEVLTlTNNVNKLLIIdySENRLLAC 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 112 GSVHQGVCEQRRLGQLeQLLLRPERPGDtQYVAANDPAVSTVGLVAQGLAGEPLLFVGRGytsrgVGGG---IPPITTRA 188
Cdd:cd11272 93 GSLYQGVCKLLRLDDL-FILVEPSHKKE-HYLSSVNKTGTMYGVIVRSEGEDGKLFIGTA-----VDGKqdyFPTLSSRK 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 189 LwPPDPQ--AAFSYE-------ETAKLAVGRLSEYSH---HFVSAFARGASAYFLFLRRDL-------QAQSRAFRAYVS 249
Cdd:cd11272 166 L-PRDPEssAMLDYElhsdfvsSLIKIPSDTLALVSHfdiFYIYGFASGNFVYFLTVQPETpegvsinSAGDLFYTSRIV 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 250 RVCLRDQHYYSYVELPLAC--EGGRYGLIQAAAVATSREV--------AHGEVLFAAFSSAAPpTVGRPPSAAAgasgas 319
Cdd:cd11272 245 RLCKDDPKFHSYVSLPFGCvrGGVEYRLLQAAYLSKPGEVlarslnitAQEDVLFAIFSKGQK-QYHHPPDDSA------ 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 320 aLCAFPLDEVDRLANRTRDACYTREGRAEdgtevayIEYDVNSD--CAQLPVDTLDAYpCGSDhTPSPMASRVPLEATPI 397
Cdd:cd11272 318 -LCAFPIRAINAQIKERLQSCYQGEGNLE-------LNWLLGKDvqCTKAPVPIDDNF-CGLD-INQPLGGSTPVEGVTL 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 398 LEWPGIQLTAVAVTMEDGHTIAFLGDSQGQLHRVYL-GPGSDGHPYSTQSI-QQGSAVSRDLTFDGTFEHLYVMTQSTLL 475
Cdd:cd11272 388 YTSSRDRLTSVASYVYNGYSVVFVGTKSGKLKKIRAdGPPHGGVQYEMVSVfKDGSPILRDMAFSIDHKYLYVMSERQVS 467
|
490 500 510 520
....*....|....*....|....*....|....*....|....*
gi 767923571 476 KVPVASCAQHLDCASCLAHRDPYCGWCVLLGRCSRRSECSRGQGP 520
Cdd:cd11272 468 RVPVESCEQYTTCGECLSSGDPHCGWCALHNMCSRRDKCQRAWEP 512
|
|
| Plexin_RBD |
pfam20170 |
Plexin cytoplasmic RhoGTPase-binding domain; This entry represents the RhoGTPase-binding ... |
1734-1850 |
1.34e-53 |
|
Plexin cytoplasmic RhoGTPase-binding domain; This entry represents the RhoGTPase-binding domain found in the cytoplasmic domain of plexins.
Pssm-ID: 466321 Cd Length: 113 Bit Score: 183.16 E-value: 1.34e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1734 LNDNRLLREDVEYRPLTLNALLAVGpgaGEAQGVPVKVLDCDTISQAKEKMLDQLYKGVPLTQRPDPRTLDVEWRSGVAG 1813
Cdd:pfam20170 1 LSEDKLLREQIDYKTLTLNVIFEEG---EVSESVPVKVLDCDTISQVKEKILDAVYKNTPYSQRPSIDDVDLEWRHGRGG 77
|
90 100 110
....*....|....*....|....*....|....*..
gi 767923571 1814 HLILSDEDVTSEVQGLWRRLNTLQHYKqVPDGATVAL 1850
Cdd:pfam20170 78 RLILQDEDSTSKVEGGWKKLNTLAHYK-VPDGATLAL 113
|
|
| Sema_plexin_A |
cd11244 |
The Sema domain, a protein interacting module, of Plexin A; Plexins serve as receptors of ... |
25-479 |
7.43e-52 |
|
The Sema domain, a protein interacting module, of Plexin A; Plexins serve as receptors of semaphorins and may be the ancestor of semaphorins. Members of the Plexin A subfamily are receptors for Sema1s, Sema3s, and Sema6s, and they mediate diverse biological functions including axon guidance, cardiovascular development, and immune function. Guanylyl cyclase Gyc76C and Off-track kinase (OTK), a putative receptor tyrosine kinase, modulate Sema1a-Plexin A mediated axon repulsion. Sema3s do not interact directly with plexin A receptors, but instead bind Neuropilin-1 or Neuropilin-2 toactivate neuropilin-plexin A holoreceptor complexes. In contrast to Sema3s, Sema6s do not require neuropilins for plexin A binding. In the complex, plexin As serve as signal-transducing subunits. An increasing number of molecules that interact with the intracellular region of Plexin A have been identified; among them are IgCAMs (in axon guidance events) and Trem2-DAP12 (in immune responses). The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.
Pssm-ID: 200505 [Multi-domain] Cd Length: 470 Bit Score: 191.19 E-value: 7.43e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 25 PTAFTPNGTYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPDECPQA-QPTNNPNQLLLV 103
Cdd:cd11244 3 TFRGEPRDWSFNHLTVHRRTGEVYVGAINRVYKLSSNLTVLVTHETGPVEDNPKCYPPPIVQTCNEPlTTTNNVNKLLLI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 104 --SPGALVVCGSVHQGVCEQRRLGQLEQLLLRPERpgDTQYVAANDPAVSTVGLVAQGLAGEPLLFVGRGYTsrGVGGGI 181
Cdd:cd11244 83 dySENRLIACGSLYQGVCKLLRLEDLFKLGEPHHK--KEHYLSGVNESGTMFGVIVSYSNGDDKLFIGTAVD--GKSEYF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 182 PPITTRALwPPDPQAA--FSYE-------ETAKLAVGRLSEYSH---HFVSAFARGASAYFLFLRRDLQ------AQSRA 243
Cdd:cd11244 159 PTLSSRKL-TADEESDgmFAYVyhdefvsSQIKIPSDTLSIIPDfdiYYVYGFSSGNFVYFLTLQPETQltpgdsTGEQF 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 244 FRAYVSRVCLRDQHYYSYVELPLACE--GGRYGLIQAAAVATSREV--------AHGEVLFAAFSSAAPPTVgRPPsaaa 313
Cdd:cd11244 238 YTSKIVRLCKDDTKFYSYVEFPIGCTrdGVEYRLLQAAYLSKPGKAlaqalgisEDEDVLFTIFSKGQKNRM-KPP---- 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 314 gasGASALCAFPLDEV-DRLANRTRdACYTREGRAEdgtevayIEYDVNSD--CAQLPVDTLDAYpCGSDHTpSPMASRV 390
Cdd:cd11244 313 ---DESALCLFTLKQInLRIKERLQ-SCYRGEGKLS-------LPWLLNKDlpCINAPLQIDDNF-CGLDMN-QPLGGSD 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 391 PLEATPILEWPGIQLTAVAVTMEDGHTIAFLGDSQGQLHRVYL-GPGSDGHPYSTQSIQQGSAVSRDLTFDGTFEHLYVM 469
Cdd:cd11244 380 MVEGIPLFTDDRDRMTSVAAYVYKGHSVVFVGTKSGKLKKIRVdGPPHNALQYETVQVVEGSPILRDMAFSPDHQYLYIM 459
|
490
....*....|
gi 767923571 470 TQSTLLKVPV 479
Cdd:cd11244 460 SERQVTRVPV 469
|
|
| Sema_plexin_A1 |
cd11271 |
The Sema domain, a protein interacting module, of Plexin A1; Plexin A1 is found in both the ... |
22-479 |
4.15e-50 |
|
The Sema domain, a protein interacting module, of Plexin A1; Plexin A1 is found in both the nervous and immune systems. Its external Sema domain is also shared by semaphorin proteins. In the nervous system, Plexin A1 mediates Sema3A axon guidance function by interacting with the Sema3A coreceptor neuropilin, resulting in actin depolarization and cell repulsion. In the immune system, Plexin A1 mediates Sema6D signaling by binding to the Sema6D-Trem2-DAP12 complex on immune cells and osteoclasts to promote Rac activation and DAP12 phosphorylation. In gene profiling experiments, Plexin A1 was identified as a CIITA (class II transactivator) regulated gene in primary dendritic cells (DCs). The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.
Pssm-ID: 200532 [Multi-domain] Cd Length: 474 Bit Score: 185.94 E-value: 4.15e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 22 PLPPTAFTPNGTYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPDECPQA-QPTNNPNQL 100
Cdd:cd11271 1 QPPFRTFTASDWSLTHLVVHNKTGEVYVGAVNRIYKLSNNLTLLRTHVTGPVEDNEKCYPPPSVQSCPHGlGTTNNVNKL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 101 LLV--SPGALVVCGSVHQGVCEQRRLGQLEQLLLRPERpgDTQYVAANDPAVSTVGLVAQGLAGEPLLFVGRGYTsrGVG 178
Cdd:cd11271 81 LLVdyAANRLIACGSASQGICQFLRLDDLFKLGEPHHR--KEHYLSSVNESGTMSGVIIEVGNGQNKLFVGTPID--GKS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 179 GGIPPITTRALWPPDPQA---AFSYEE---TAKLAV-----GRLSEYSHHFVSAFARGASAYFLFLRRDLQAQS------ 241
Cdd:cd11271 157 EYFPTLSSRKLMANEENAemfGFVYQDefvSSQLKIpsdtlSKFPTFDIYYVYSFSSEQFVYYLTLQLDTQLTSpdstge 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 242 RAFRAYVSRVCLRDQHYYSYVELPLACE--GGRYGLIQAA-------AVATSREVAHGE-VLFAAFSSAAPPTVgRPPsa 311
Cdd:cd11271 237 QFFTSKIVRLCVDDPKFYSYVEFPIGCEqdGVEYRLIQDAylskpgkALAKQLGISEREdILFTVFSQGQKNRV-KPP-- 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 312 aagasGASALCAFPLDEV-DRLANRTRdACYTREGRAEdgtevayIEYDVNSD--CAQLPVDTLDAYpCGSDHTpSPMAS 388
Cdd:cd11271 314 -----KESVLCLFTLKKIkDKIKERIQ-SCYRGEGKLS-------LPWLLNKElgCINSPLQIDDNF-CGQDFN-QPLGG 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 389 RVPLEATPILEWPGIQLTAVAVTMEDGHTIAFLGDSQGQLHRVYLG-PGSDGHP---YSTQSIQQGSAVSRDLTFDGTFE 464
Cdd:cd11271 379 TVTIEGTPLFVDKEDGMTSVAAYDYRGRTVVFAGTRSGRIKKILVDlSAPSSRPalqYENVVAHEGSPILRDLVLSPDRQ 458
|
490
....*....|....*
gi 767923571 465 HLYVMTQSTLLKVPV 479
Cdd:cd11271 459 YIYAMTEKQVTRVPV 473
|
|
| Sema_plexin_A3 |
cd11273 |
The Sema domain, a protein interacting module, of Plexin A3; Plexin-A3 forms a receptor ... |
24-479 |
4.63e-49 |
|
The Sema domain, a protein interacting module, of Plexin A3; Plexin-A3 forms a receptor complex with neuropilin-2 and transduces signals for class 3 semaphorins in the nervous system. Both plexins A3 and A4 are essential for normal sympathetic neuron development. They function cooperatively to regulate the migration of sympathetic neurons, and differentially to guide sympathetic axons. Both plexins A3 and A4 are not required for guiding neural crest precursors prior to reaching the sympathetic anlagen. Plexin A3 is a major driving force for intraspinal motor growth cone guidance. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.
Pssm-ID: 200534 [Multi-domain] Cd Length: 469 Bit Score: 182.83 E-value: 4.63e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 24 PPTAFTPNGTYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPDECPQA-QPTNNPNQLLL 102
Cdd:cd11273 2 PFRAFVVTDTTLTHLAVHRVTGEVFVGAVNRVYKLSANLTELRAHVTGPVEDNARCYPPPSVRVCAHRlAPVDNVNKLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 103 VSPGA--LVVCGSVHQGVCEQRRLGQLEQLLLRPERpgDTQYVAANDPAVSTVGLVAQGLAGEPLLFVGRGytsrgVGGG 180
Cdd:cd11273 82 VDYAGnrLVACGSIWQGVCQFLRLEDLFKLGEPHHR--KEHYLSGAQEPDSMAGVIVEQGKGPSKLFVGTA-----IDGK 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 181 ---IPPITTRALWPPDPQA-AFS--YEE-----TAKLAVGRLSEYSH---HFVSAFARGASAYFLFLRRDLQ------AQ 240
Cdd:cd11273 155 seyFPTLSSRKLISDEDSAdMFSlvYQDefvssQIKIPSDTLSLYPAfdiYYVYGFVSASFVYFLTLQLDTQqtlldtAG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 241 SRAFRAYVSRVCLRDQHYYSYVELPLAC--EGGRYGLIQAA-------AVATSREVAHGE-VLFAAFSS-----AAPPtv 305
Cdd:cd11273 235 EKFFTSKIVRMCANDTEFYSYVEFPLGCskDGVEYRLVQAAhlakpglLLAQALGVPEDEdVLFTIFSQgqknrASPP-- 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 306 grppsaaagasGASALCAFPLDEVDRLANRTRDACYTREGRAEdgtevayIEYDVNSD--CAQLPVDTLDAYpCGSDHTp 383
Cdd:cd11273 313 -----------RETILCLFTLSNINAHIRERIQSCYRGEGTLS-------LPWLLNKElpCINTPMQINGNF-CGLVLN- 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 384 SPMASRVPLEATPILEWPGIQLTAVAVTMEDGHTIAFLGDSQGQLHRVYLGPGSDGHPYSTQSIQQGSAVSRDLTFDGTF 463
Cdd:cd11273 373 QPLGGLHVIEGLPLLADSTDGMASVAAYTYRQHSVVFIGTRSGSLKKVRVDGFQDAHLYETVPVVDGSPILRDMVFSPDH 452
|
490
....*....|....*.
gi 767923571 464 EHLYVMTQSTLLKVPV 479
Cdd:cd11273 453 RYIYLLSEKQVSQLPV 468
|
|
| Sema_plexin_A4 |
cd11274 |
The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor ... |
30-482 |
5.55e-45 |
|
The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor complex with neuropilins (NRPs) and transduces signals for class 3 semaphorins in the nervous system. It regulates facial nerve development by functioning as a receptor for Sema3A/NRP1. Both plexins A3 and A4 are essential for normal sympathetic development. They function both cooperatively, to regulate the migration of sympathetic neurons, and differentially, to guide sympathetic axons. Plexin A4 is also expressed in lymphoid tissues and functions in the immune system. It negatively regulates T lymphocyte responses. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.
Pssm-ID: 200535 [Multi-domain] Cd Length: 473 Bit Score: 170.90 E-value: 5.55e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 30 PNGTYlQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPDEC-PQAQPTNNPNQLLLVS--PG 106
Cdd:cd11274 9 TEWTF-NHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHQTGPDEDNPKCYPPRIVQTCnEPLTLTNNINKMLLIDykEN 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 107 ALVVCGSVHQGVCEQRRLGQLEQlLLRPERPGDtQYVAANDPAVSTVGLVAQGLAGEPLLFVGRGYTsrGVGGGIPPITT 186
Cdd:cd11274 88 RLIACGSLYQGICKLLRLDDLFK-LGEPFHKKE-HYLSGVNESGSVFGVIVSYSNLDDKLFIATAVD--GKPEYFPTISS 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 187 RALWP-PDPQAAFSY----EETAKL------AVGRLSEYSHHFVSAFARGASAYFLFLRRDL------QAQSRAFRAYVS 249
Cdd:cd11274 164 RKLTKnSEADGMFAYvfhdEFVASMikipsdTFTIIPDFDIYYIYGFSSGNFVYFLTLQPEMisppgsTTKEQVYTSKLV 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 250 RVCLRDQHYYSYVELPLACE--GGRYGLIQAAAVATS-----REVAHG---EVLFAAFSSAApptvgrppSAAAGASGAS 319
Cdd:cd11274 244 RLCKEDTAFNSYVEVPIGCEknGVEYRLLQAAYLSKAgailaRSLGVGpddDILFTVFSKGQ--------KRKMKSLDES 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 320 ALCAFPLDEV-DRLANRTRdACYtregRAEDGTEVAYIEY-DVNSDCAQLPVDtlDAYpCGSDHTpSPMASRVPLEATPI 397
Cdd:cd11274 316 ALCIFVLKEInDRIKDRLQ-SCY----RGEGTLDLAWLKVkDIPCSSALLTID--DNF-CGLDMN-APLGVSEMVRGLPV 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 398 LEWPGIQLTAVAVTMEDGHTIAFLGDSQGQLHRVYL-GPGSDGHPYSTQSIQQGSAVSRDLTFDGTFEHLYVMTQSTLLK 476
Cdd:cd11274 387 FTEDRDRMTSVIAYVYKNHSLAFVGTKSGKLKKIRVdGTTKNALQYETVQVVDTGPILRDMAFSKDHEQLYIMSEKQLTR 466
|
....*.
gi 767923571 477 VPVASC 482
Cdd:cd11274 467 VPVESC 472
|
|
| Sema_plexin_D1 |
cd11247 |
The Sema domain, a protein interacting module, of Plexin D1; Plexins are known as semaphorin ... |
39-480 |
1.54e-43 |
|
The Sema domain, a protein interacting module, of Plexin D1; Plexins are known as semaphorin receptors and Plexin D1 has been identified as the receptor of Sema3E. It binds to Sema3E directly with high affinity. Sema3E is implicated in axonal path finding and inhibition of developmental and post-ischemic angiogenesis. Plexin D1 is broadly expressed on tumor vessels and tumor cells in a number of different types of human tumors. Plexin D1-Sema3E interaction inhibits tumor growth but promotes invasiveness and metastasis. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.
Pssm-ID: 200508 [Multi-domain] Cd Length: 483 Bit Score: 166.95 E-value: 1.54e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 39 ARDPTSGTLYLGATNFLFQLSPG-LQLEATVSTGPVLDSRDCLPPVMPDE-CPQAQP-TNNPNQLLLVSP--GALVVCGS 113
Cdd:cd11247 15 ALDGGRGRLYLAAVNRLYQLSGLvLALEAEAAVGPVLDSPLCHAPQLPQAtCEHPRTlTDNYNKILQPDPeqGVLVVCGS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 114 VHQGVCEQRRLGQLEQLLLRPERPGDTQY-----VAANDPAVSTVGLVA--QGLAGEPLLFVGRGYTSRGVGG------- 179
Cdd:cd11247 95 IYQGLCQLRRLYNISAVAVRFPVDGDTVFpsmlnVAANHPNASTVGLVLwpRGGGGGLRLLVGATYTGYGSGFfprnrsl 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 180 ------GIPPITTRAL-------------WPPDPQAAFSYEETAKlAVGRLSeyshhFVSAFARGASAYFLFLRRDLQA- 239
Cdd:cd11247 175 edhrfeNTPEIAIRALntrgdlaklftfdINPSDDNIFKIKQGAK-ARHKLS-----FVRAFLQHFLQPYAYLAMNGEAn 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 240 ----QSRAfRAYVSRVCLRDQH----------YYSYVELPLACEGGrYGLIQAAAVATSREvahgEVLFAAFSSAAPptv 305
Cdd:cd11247 249 aagkESQP-PSLLARICLPGRAppppgeakklTESYIQLGLRCEGA-YTRLVSVFPARVEE----EQLFAVFERAGG--- 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 306 grppsaaagasGASALCAFPLDEVDRLANRTRDACYtrEGRAEDgtEVAYIEYDVNSDCA--------QLPVDTLDaypC 377
Cdd:cd11247 320 -----------APAALCAFRFAEVEEPIRAARTACF--VSPAAG--VVTVLDSVVQGTGPacerklniQLQPEQLD---C 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 378 GSDHTPSPMASRVPLEATPILEWPGiqLTAVAVTMEDGHTIAFLGDSQGQLHRVYLGPGSDGHPYSTQSIQQGSAVSRDL 457
Cdd:cd11247 382 GAAHLQHPLAILQPLKATPVFRAPG--LTSVAVASVNNYTVVFLGTVSGRLLKINLDESMQVVSRRSVTVAYGEPVHHVM 459
|
490 500
....*....|....*....|....
gi 767923571 458 TFDGTFE-HLYVMTQSTLLKVPVA 480
Cdd:cd11247 460 QFDPSDStYLYLMTSHQMTRVKVA 483
|
|
| TIG_2 |
pfam18020 |
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG ... |
921-1020 |
7.38e-34 |
|
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG domains have an Ig-like fold.
Pssm-ID: 465619 Cd Length: 94 Bit Score: 126.24 E-value: 7.38e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 921 GSTLMPVHVEREIRLLGRNLHLFQDGPGDNECVMELEGLEVVVEARVECEPppdtqcHVTCQQHQLSYEALQPELRVGLF 1000
Cdd:pfam18020 1 GSILVPVGVEREITLKARNLPLFQSGQLGYECVFEIEGATHVVPASRESSD------SITCQEHQFSYSGSSGELPATFY 74
|
90 100
....*....|....*....|
gi 767923571 1001 LRRAGRLRVDSAEGLHVVLY 1020
Cdd:pfam18020 75 VTWNGGHRLDNPANLQVVLY 94
|
|
| IPT_plexin_repeat1 |
cd01180 |
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ... |
1070-1161 |
2.52e-33 |
|
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.
Pssm-ID: 238585 Cd Length: 94 Bit Score: 124.74 E-value: 2.52e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1070 PLIHSVEPLTGPVDGGTRVTIRGSNLGQHVQDVLGMVTVAGVPCAVDAQEYEVSSSLVCITGASGEEVaGATAVEVPGRG 1149
Cdd:cd01180 1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNPV-FNGPVEVTVGH 79
|
90
....*....|....*
gi 767923571 1150 ---RGVSEHDFAYQD 1161
Cdd:cd01180 80 gsfRTESSEGFSFVD 94
|
|
| IPT_plexin_repeat3 |
cd01181 |
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ... |
1252-1376 |
4.19e-32 |
|
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.
Pssm-ID: 238586 Cd Length: 99 Bit Score: 121.37 E-value: 4.19e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1252 PNITSAGPTKSFLSGGREICVRGQNLDVVQTPRIRVTVVSRmlqpsqglgrrrrvvpetacslgpscssqqFEEPCHVNS 1331
Cdd:cd01181 1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRVKYGGV------------------------------EKTSCKVRN 50
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 767923571 1332 SQLITCRTPALPGLP---EDPWVRVEFILDNLVF-DFATLNPTPFSYEA 1376
Cdd:cd01181 51 STLMTCPAPSLALLNrspEPGERPVEFGLDGDNVqSLLILNRTSFSYYP 99
|
|
| IPT_plexin_repeat2 |
cd01179 |
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ... |
1162-1249 |
4.36e-27 |
|
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.
Pssm-ID: 238584 Cd Length: 85 Bit Score: 106.54 E-value: 4.36e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1162 PKVHSIFPARGPRAGGTRLTLNGSKLLTGRleDIRVVVGDQPCHLLPeQQSEQLRCETSPRPTPATLPVAVWFGATeRRL 1241
Cdd:cd01179 1 PSITSLSPSYGPQSGGTRLTITGKHLNAGS--SVRVTVGGQPCKILS-VSSSQIVCLTPPSASPGEAPVKVLIDGA-RRL 76
|
....*...
gi 767923571 1242 QRGQFKYT 1249
Cdd:cd01179 77 APLVFTYT 84
|
|
| TIG_plexin |
pfam17960 |
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ... |
541-627 |
1.43e-26 |
|
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.
Pssm-ID: 465588 Cd Length: 89 Bit Score: 105.04 E-value: 1.43e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 541 PANISREETREVFLSVPDLPPLwpGESYSCHFGEH-QSPALLTGSGVMCPSPDPSEAPVLPRGADYVSVSVELRFGA--V 617
Cdd:pfam17960 2 PDNISRTTATQLTLTVPNLPAL--SEGYSCVFGDLtESPATVHDNGVKCATPPPSQLPPIPTGQDHVTVKLSLRSSEtgV 79
|
90
....*....|
gi 767923571 618 VIAKTSLSFY 627
Cdd:pfam17960 80 DFASTNFTFY 89
|
|
| Sema_MET_like |
cd11248 |
The Sema domain, a protein interacting module, of MET and RON receptor tyrosine kinases; This ... |
32-479 |
1.26e-23 |
|
The Sema domain, a protein interacting module, of MET and RON receptor tyrosine kinases; This family includes MET and RON receptor tyrosine kinases. MET is encoded by the c-met protooncogene. MET is the receptor for hepatocyte growth factor/scatter factor (HGF/SF). HGF/SF and MET regulates multiple cellular events and are essential for the development of several tissues and organs, including the placenta, liver, and several groups of skeletal muscles. RON receptor tyrosine kinase is a Macrophage-stimulating protein (MSP) receptor. Upon binding of MSP, RON is activated via autophosphorylation within its kinase catalytic domain, resulting in a variety of effects including proliferation, tubular morphogenesis, angiogenesis, cellular motility and invasiveness. By interacting with downstream signaling molecules, it regulates macrophage migration, phagocytosis, and nitric oxide production. MET and RON receptors have been implicated in cancer development and migration. They are composed of alpha-beta heterodimers. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The Sema domain is necessary for receptor dimerization and activation.
Pssm-ID: 200509 [Multi-domain] Cd Length: 467 Bit Score: 106.74 E-value: 1.26e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 32 GTYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLdSRDCLPPvmPDECPQAQP---TNNPNQLLLVSPG-- 106
Cdd:cd11248 7 DTPIQNIVLNEGSTEVYVAAQNVIYALNPDLQKVWEYKTGPVG-SPDCQTC--QDCSSGADPgvpKDTDNMVLVLETYyd 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 107 -ALVVCGSVHQGVCEQRRL------GQLEQLLLRPER---PGDTQYVAAndPAVSTVGLVAQGLAgePLLFVGRGYTSRg 176
Cdd:cd11248 84 dYLYSCGSTQNGVCYRHVLedgadiQSEVHCLFSKKNnspSYCPDCVAS--PLGTKVTNVESGRT--IYFFVANSVNSS- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 177 VGGGIPPITTRALWPPDPQAAFsYEETAKLAV--GRLSEYSHHFVSAFARGASAYFLFLRRD-LQAQSRAFRAYVSRVCL 253
Cdd:cd11248 159 LAGSFPPHSISVRRLKEDGFGF-LSDQSYLDVlpSLRDSYPIKYVYSFHSGPFVYFLTVQREsLTKPSSAFHTRLVRLCS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 254 RDQHYYSYVELPLAC-------EGGR-----YGLIQAAAVATS-REVA-------HGEVLFAAFSSAAPPTVGRPPSAAa 313
Cdd:cd11248 238 SDSEIWRYREMPLECiftpkrrRRSTeedvvYNVLQAAHVSKVgADLAdelgaseGDDILFGVFARSKPDSGEPMPNSA- 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 314 gasgasaLCAFPLDEVDRLANRTRDACYTRegraedGTEVAYieydvNSDCAQLPVDTL--DAYPCGS--DHTPSPMAS- 388
Cdd:cd11248 317 -------LCAFPIKYVNDAIEKGVEKCCTS------GLEHFS-----GSLCHFQPCPTCpgESSSCEAtcKEYRTEVTKp 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 389 --RVPL---EATPILewpgiqLTAVAVTMEDGHTIAFLGDSQGQLHRVYLGPgSDGHPYSTQSIqQGSAVSRDLTFDGTF 463
Cdd:cd11248 379 yqRVDLfngQMSNVL------LTSILVTTIGNHTVAHLGTSDGRVLQVVLSR-SGPIPHVNFSL-DSQPVSREVAVLSSN 450
|
490
....*....|....*.
gi 767923571 464 EHLYVMTQSTLLKVPV 479
Cdd:cd11248 451 GSLLFVTGDKITKVPL 466
|
|
| IPT_PCSR |
cd00603 |
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ... |
1162-1249 |
8.69e-19 |
|
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.
Pssm-ID: 238337 [Multi-domain] Cd Length: 90 Bit Score: 82.89 E-value: 8.69e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1162 PKVHSIFPARGPRAGGTRLTLNGSKLLTGRlEDIRVVVGDQPCHLLPeQQSEQLRCETSPRPTPATLPVAVWFG---ATE 1238
Cdd:cd00603 1 PVITSISPSSGPLSGGTRLTITGSNLGSGS-PRVRVTVGGVPCKVLN-VSSTEIVCRTPAAATPGEGPVEVTVDganVSA 78
|
90
....*....|.
gi 767923571 1239 RRLQRGQFKYT 1249
Cdd:cd00603 79 RVLSNTTFTYV 89
|
|
| Sema |
pfam01403 |
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ... |
276-460 |
2.20e-17 |
|
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805
Pssm-ID: 460197 [Multi-domain] Cd Length: 180 Bit Score: 81.93 E-value: 2.20e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 276 IQAAAVAT-SREVAHGEVLFAAFSSAAPPTVGRppsaaagasgaSALCAFPLDEVDRLANRtRDACYTREGRAEDGTEVA 354
Cdd:pfam01403 1 LQDVFVLKpGAGDALDTVLYGVFTTQWSNSIGG-----------SAVCAFSLSDINAVFEG-PFKEQEKSDSKWLPYTGK 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 355 yIEYDVNSDCAQLPV--DTLDAYPCGSDHTPSPMASRVPLEATPILEWPGIQLTAVAVTM---EDG-HTIAFLGDSQGQL 428
Cdd:pfam01403 69 -VPYPRPGTCINDPLrlDLPDSVLNFVKDHPLMDEAVQPVGGRPLLVRTGVRLTSIAVDRvqaLDGnYTVLFLGTDDGRL 147
|
170 180 190
....*....|....*....|....*....|...
gi 767923571 429 HRVYLGPGSDGHPYSTQSI-QQGSAVSRDLTFD 460
Cdd:pfam01403 148 HKVVLVGSEESHIIEEIQVfPEPQPVLNLLLSS 180
|
|
| IPT_PCSR |
cd00603 |
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ... |
1070-1161 |
1.31e-16 |
|
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.
Pssm-ID: 238337 [Multi-domain] Cd Length: 90 Bit Score: 76.72 E-value: 1.31e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1070 PLIHSVEPLTGPVDGGTRVTIRGSNLGQHVQDVlgMVTVAGVPCAVdaqEYEVSSSLVCITGASGEEVAGATAVEVPGRG 1149
Cdd:cd00603 1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRV--RVTVGGVPCKV---LNVSSTEIVCRTPAAATPGEGPVEVTVDGAN 75
|
90
....*....|....*
gi 767923571 1150 ---RGVSEHDFAYQD 1161
Cdd:cd00603 76 vsaRVLSNTTFTYVE 90
|
|
| IPT |
smart00429 |
ig-like, plexins, transcription factors; |
1161-1249 |
3.31e-16 |
|
ig-like, plexins, transcription factors;
Pssm-ID: 214657 [Multi-domain] Cd Length: 90 Bit Score: 75.53 E-value: 3.31e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1161 DPKVHSIFPARGPRAGGTRLTLNGSKLLTGRLEDIRVVVGDQPCHLLPEQQSeQLRCETSPRPT-PATLPV-AVWFGATE 1238
Cdd:smart00429 1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEAPCTFSPSSST-AIVCKTPPYHNiPGSVPVrTVGLRNGG 79
|
90
....*....|.
gi 767923571 1239 RRLQRGQFKYT 1249
Cdd:smart00429 80 VPSSPQPFTYV 90
|
|
| PSI |
pfam01437 |
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ... |
481-527 |
1.13e-14 |
|
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).
Pssm-ID: 396154 [Multi-domain] Cd Length: 52 Bit Score: 70.04 E-value: 1.13e-14
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 767923571 481 SCAQHLDCASCLAHRDPYCGWCVLLGRCSRRSECSrGQGPEQWLWSF 527
Cdd:pfam01437 1 RCSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACG-APEGNCEEWEQ 46
|
|
| IPT |
cd00102 |
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ... |
1162-1249 |
3.16e-14 |
|
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.
Pssm-ID: 238050 [Multi-domain] Cd Length: 89 Bit Score: 69.80 E-value: 3.16e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1162 PKVHSIFPARGPRAGGTRLTLNGSKLLTGRleDIRVVV-GDQPCHLLPeQQSEQLRCETSPRPTPATLPVAVWF--GATE 1238
Cdd:cd00102 1 PVITSISPSSGPVSGGTEVTITGSNFGSGS--NLRVTFgGGVPCSVLS-VSSTAIVCTTPPYANPGPGPVEVTVdrGNGG 77
|
90
....*....|.
gi 767923571 1239 RRLQRGQFKYT 1249
Cdd:cd00102 78 ITSSPLTFTYV 88
|
|
| IPT |
smart00429 |
ig-like, plexins, transcription factors; |
1070-1159 |
7.52e-14 |
|
ig-like, plexins, transcription factors;
Pssm-ID: 214657 [Multi-domain] Cd Length: 90 Bit Score: 68.99 E-value: 7.52e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1070 PLIHSVEPLTGPVDGGTRVTIRGSNLGQhVQDVLGMVTVAGVPCAVDAQEyevSSSLVCITGASGEEVAGATAVEVPGRG 1149
Cdd:smart00429 2 PVITRISPTSGPVSGGTEITLCGKNLKS-ISVVFVEVGVGEAPCTFSPSS---STAIVCKTPPYHNIPGSVPVRTVGLRN 77
|
90
....*....|..
gi 767923571 1150 RGV--SEHDFAY 1159
Cdd:smart00429 78 GGVpsSPQPFTY 89
|
|
| RasGAP |
cd04519 |
Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is ... |
1917-2059 |
2.13e-13 |
|
Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin, among others. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP exhibit no similarity at their amino acid sequence level. RasGTPases function as molecular switches in a large number of signaling pathways. They are in the on state when bound to GTP, and in the off state when bound to GDP. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.
Pssm-ID: 213328 Cd Length: 256 Bit Score: 72.52 E-value: 2.13e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1917 EIYLTRLLSMKGTLQKFVDDLFQVILSTSRPVPLAVKYFFDLLDEQAQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQ- 1995
Cdd:cd04519 115 LPVGEDLEENLENLLELVNKLVDRILSSLDRLPPELRYVFKILREFLAERFPEEPDEAYQAVSGFLFLRFICPAIVSPEl 194
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767923571 1996 -FVFDVQTSDNMDAVLLVIAQTFMDACTLADH--KLGRDSPINkllyaRDIPRYKRMVERYYADIRQ 2059
Cdd:cd04519 195 fGLVPDEPSEQARRNLTLISKVLQSLANGVEFgdKEPFMKPLN-----DFIKSNKPKLKQFLDELSS 256
|
|
| IPT |
cd00102 |
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ... |
1070-1161 |
6.62e-13 |
|
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.
Pssm-ID: 238050 [Multi-domain] Cd Length: 89 Bit Score: 66.33 E-value: 6.62e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1070 PLIHSVEPLTGPVDGGTRVTIRGSNLGQHVQdvlGMVTV-AGVPCAVdaqEYEVSSSLVCITGASGEEVAGATAVEV--P 1146
Cdd:cd00102 1 PVITSISPSSGPVSGGTEVTITGSNFGSGSN---LRVTFgGGVPCSV---LSVSSTAIVCTTPPYANPGPGPVEVTVdrG 74
|
90
....*....|....*
gi 767923571 1147 GRGRGVSEHDFAYQD 1161
Cdd:cd00102 75 NGGITSSPLTFTYVP 89
|
|
| IPT_PCSR |
cd00603 |
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ... |
1252-1375 |
6.91e-13 |
|
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.
Pssm-ID: 238337 [Multi-domain] Cd Length: 90 Bit Score: 66.32 E-value: 6.91e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1252 PNITSAGPTKSFLSGGREICVRGQNLDVVQtPRIRVTVVSRmlqpsqglgrrrrvvpetacslgpscssqqfeePCHVN- 1330
Cdd:cd00603 1 PVITSISPSSGPLSGGTRLTITGSNLGSGS-PRVRVTVGGV---------------------------------PCKVLn 46
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 767923571 1331 -SSQLITCRTPALPGLPEDPwvrVEFILDNLVFDFATLNPTPFSYE 1375
Cdd:cd00603 47 vSSTEIVCRTPAAATPGEGP---VEVTVDGANVSARVLSNTTFTYV 89
|
|
| Sema_MET |
cd11278 |
The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor ... |
45-338 |
2.56e-12 |
|
The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR); MET is encoded by the c-met protooncogene. MET is a receptor tyrosine kinase that binds its ligand, hepatocyte growth factor/scatter factor (HGF/SF). HGF/SF and MET are essential for the development of several tissues and organs, including the placenta, liver, and several groups of skeletal muscles. It also plays a major role in the abnormal migration of cancer cells as a result of overexpression or MET mutations. MET is composed of an alpha-beta heterodimer. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The cytoplasmic C-terminal region acts as a docking site for multiple protein substrates, including Grb2, Gab1, STAT3, Shc, SHIP-1 and Src. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. The Sema domain of Met is necessary for receptor dimerization and activation.
Pssm-ID: 200539 [Multi-domain] Cd Length: 492 Bit Score: 71.82 E-value: 2.56e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 45 GTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPvmpDEC-PQAQPTN-----NPNQLLLVSP---GALVVCGSVH 115
Cdd:cd11278 36 HHIYVGAVNKIYVLNEDLQKVSEYKTGPVLEHPDCFPC---QDCsDKANLSNgvwkdNVNMALFVETyydDQLISCGSVN 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 116 QGVCeQRRLgqleqllLRPERPGDTQ------YVA--------ANDPAVSTVGlvAQGLAGEPLLFVGRGYTSRGVGGGI 181
Cdd:cd11278 113 RGTC-QRHV-------FPHDHPADIQsevhciYSPqieeepdqCPDCVVSTLG--SKVLVTVKDRFVNFFVGNTINSSYF 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 182 PP-----ITTRALwpPDPQAAFSYEeTAKLAVGRLSE----YSHHFVSAFARGASAYFLFLRRDlQAQSRAFRAYVSRVC 252
Cdd:cd11278 183 PDhplhsISVRRL--KETQDGFEFL-TDQSYIDVLPEfrdsYPIKYVHAFESNNFVYFLTVQRE-SLDSQTFHTRIIRFC 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 253 LRDQHYYSYVELPLAC-----------EGGRYGLIQAAAV-----ATSREVAHG---EVLFAAFSSAAPPTvgrppsaaA 313
Cdd:cd11278 259 SIDSELRSYMEMPLECiftekrrkrstKKEVFNILQAAYVskpgaQLAREMGASlndDILFGVFAQSKPDS--------A 330
|
330 340
....*....|....*....|....*
gi 767923571 314 GASGASALCAFPLDEVDRLANRTRD 338
Cdd:cd11278 331 EPMNRSAVCAVSIKTINEFFNKIVD 355
|
|
| PSI |
smart00423 |
domain found in Plexins, Semaphorins and Integrins; |
482-520 |
3.59e-12 |
|
domain found in Plexins, Semaphorins and Integrins;
Pssm-ID: 214655 [Multi-domain] Cd Length: 47 Bit Score: 62.56 E-value: 3.59e-12
10 20 30
....*....|....*....|....*....|....*....
gi 767923571 482 CAQHLDCASCLAHRDPYCGWCVLLGRCSRRSECSRGQGP 520
Cdd:smart00423 2 CSKYTSCSECLLARDPYCAWCSSQGRCTSGERCDSRRQN 40
|
|
| IPT |
smart00429 |
ig-like, plexins, transcription factors; |
1251-1374 |
1.18e-11 |
|
ig-like, plexins, transcription factors;
Pssm-ID: 214657 [Multi-domain] Cd Length: 90 Bit Score: 62.82 E-value: 1.18e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1251 DPNITSAGPTKSFLSGGREICVRGQNLDVVQTPRIRVTVVsrmlqpsqglgrrrrvvpETACSLGPSCSSQqfeepchvn 1330
Cdd:smart00429 1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVG------------------EAPCTFSPSSSTA--------- 53
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 767923571 1331 ssqlITCRTPALPGLPEDPWVR-VEFILDNLVFDfatlnPTPFSY 1374
Cdd:smart00429 54 ----IVCKTPPYHNIPGSVPVRtVGLRNGGVPSS-----PQPFTY 89
|
|
| Sema_RON |
cd11279 |
The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase; RON receptor ... |
32-479 |
1.38e-11 |
|
The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase; RON receptor tyrosine kinase is a Macrophage-stimulating protein (MSP) receptor. Upon binding of MSP, RON is activated via autophosphorylation within its kinase catalytic domain, resulting in a wide range of effects, including proliferation, tubular morphogenesis, angiogenesis, cellular motility and invasiveness. By interacting with downstream signaling molecules, it regulates macrophage migration, phagocytosis, and nitric oxide production. RON has been implicated in cancers of the breast, colon, pancreas and ovaries because both splice variants and receptor overexpression have been identified in these tumors. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as ligand recognition and binding model. RON is composed of an alpha-beta heterodimer. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The Sema domain of RON may be necessary for receptor dimerization and activation.
Pssm-ID: 200540 [Multi-domain] Cd Length: 493 Bit Score: 69.42 E-value: 1.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 32 GTYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVlDSRDClppVMPDECPQAQPTNNP----NQLLLVSPG- 106
Cdd:cd11279 26 GSPIQNIVSYEDASAVFVATRNHLHVLNPELKLLQNLVTGPT-GSPGC---QICALCPPGPPGPSPedtdNKVLVLDPEe 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 107 -ALVVCGSVHQGVCeqrRLGQLEQLLlRPERPGDTQ--YVAANDPAVSTVGLVAQGLaGEPLLFVGRGYTS--------- 174
Cdd:cd11279 102 pWLYSCGSSLHGRC---FLHELESRG-SAVHIASTAclFSANANKPSDCPDCVASPL-GTRVTVVEQSHTSyfyvastln 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 175 RGVGGGIPP--ITTRALWPPDPQAAFSYEETAKLAVGRLSeYSHHFVSAFARGASAYFLFLRRDlQAQSRAFRAYVSRVC 252
Cdd:cd11279 177 SSVAASYSPrsVSIRRLKSDQDGFAPGFHSLTVLPKYLDS-YPIHYVHSFTSGDFVYFLTVQPE-SPDSSAYHTRLVRLS 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 253 LRDQHYYSYVELPLAC--------------EGGRYGLIQAAAVAT-----SRE--VAHGE-VLFAAFSSAAPPTVGRPPS 310
Cdd:cd11279 255 AKEPELRDYRELVLDCrfepkrrrrrrpaeREVPYNVLQAAHAAPvgsklAVElgISEGQeVLFGVFAESQPGSPVPQKN 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 311 AAagasgasaLCAFPLDEVDRLANRTRDACYtrEGRAEDGTEVAYIEYDVNSDCAQLPVDTLDAYPCGSDHTP---SPMA 387
Cdd:cd11279 335 SA--------VCAFPISLLNEAIDEGMEKCC--SSSNSDRLFRGLDFFQPQSYCPHPPNLSAAVSNTSCWNFPtlvSTSS 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 388 SRVPLEATPIlewPGIQLTAVAVTMEDGHTIAFLGDSQGQLHRVYLGPGSDGHPY-STQSIQQGSAVSRDLTFDGtfEHL 466
Cdd:cd11279 405 FRVDLFNGHL---SGVLLTSIYVTVLDNVTVAHLGTSDGRILQVVLQRSLNYLLYvSNFSLGDGQPVQRDVSRLG--DSL 479
|
490
....*....|...
gi 767923571 467 YVMTQSTLLKVPV 479
Cdd:cd11279 480 LFASGNQVFKVNI 492
|
|
| IPT_plexin_repeat1 |
cd01180 |
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ... |
1162-1232 |
2.98e-11 |
|
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.
Pssm-ID: 238585 Cd Length: 94 Bit Score: 61.56 E-value: 2.98e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767923571 1162 PKVHSIFPARGPRAGGTRLTLNGSKLltG-RLEDIR--VVVGDQPCHLLPE--QQSEQLRCETSPRPTPA-TLPVAV 1232
Cdd:cd01180 1 PVITEFFPLSGPLEGGTRLTICGSNL--GlRKNDVRhgVRVGGVPCNPEPPeySSSEKIVCTTGPAGNPVfNGPVEV 75
|
|
| TIG |
pfam01833 |
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ... |
1070-1159 |
7.70e-11 |
|
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.
Pssm-ID: 460355 [Multi-domain] Cd Length: 84 Bit Score: 60.15 E-value: 7.70e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1070 PLIHSVEPLTGPVDGGTRVTIRGSNLGQHVQDVlgMVTVAGVPCAVDAQEyevSSSLVCITGASGEEVAGATaVEVPGRG 1149
Cdd:pfam01833 1 PVITSISPSSGPASGGTTITITGSNFGTDSSDL--KVTIGGTPCTVISVS---STTIVCTTPPGTSGLVNVS-VTVGGGG 74
|
90
....*....|
gi 767923571 1150 RGVSEHDFAY 1159
Cdd:pfam01833 75 ISSSPLTFTY 84
|
|
| TIG |
pfam01833 |
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ... |
1162-1248 |
1.42e-10 |
|
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.
Pssm-ID: 460355 [Multi-domain] Cd Length: 84 Bit Score: 59.38 E-value: 1.42e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1162 PKVHSIFPARGPRAGGTRLTLNGSKLLTGRlEDIRVVVGDQPChLLPEQQSEQLRCETSPRpTPATLPVAVWFGATERRL 1241
Cdd:pfam01833 1 PVITSISPSSGPASGGTTITITGSNFGTDS-SDLKVTIGGTPC-TVISVSSTTIVCTTPPG-TSGLVNVSVTVGGGGISS 77
|
....*..
gi 767923571 1242 QRGQFKY 1248
Cdd:pfam01833 78 SPLTFTY 84
|
|
| IPT |
cd00102 |
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ... |
1252-1374 |
1.87e-09 |
|
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.
Pssm-ID: 238050 [Multi-domain] Cd Length: 89 Bit Score: 56.32 E-value: 1.87e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1252 PNITSAGPTKSFLSGGREICVRGQNLDVVQTPRIRVTVvsrmlqpsqglgrrrrvvpETACSLGPSCSSQqfeepchvns 1331
Cdd:cd00102 1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTFGG-------------------GVPCSVLSVSSTA---------- 51
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 767923571 1332 sqlITCRTPALPGLPEdpwVRVEFILDNLVfDFATLNPTPFSY 1374
Cdd:cd00102 52 ---IVCTTPPYANPGP---GPVEVTVDRGN-GGITSSPLTFTY 87
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
681-839 |
3.96e-08 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 59.18 E-value: 3.96e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 681 SPDPPARGGPsPSPPTAPKALATPAPDTLPVEPGAPSTATASDISPGASPSLLSPwgpwagsgsiSSPGSTGSPLHEEPS 760
Cdd:PHA03247 2732 SPALPAAPAP-PAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTR----------PAVASLSESRESLPS 2800
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 761 PPSPQNGPGTAVPAPTDFRPSATPEDLLASPLSPSEVAAVPPADPGPEALHP------------TVPLDLPPATVPATTF 828
Cdd:PHA03247 2801 PWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLggsvapggdvrrRPPSRSPAAKPAAPAR 2880
|
170
....*....|.
gi 767923571 829 PGAMGSVKPAL 839
Cdd:PHA03247 2881 PPVRRLARPAV 2891
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
661-880 |
8.07e-08 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 57.69 E-value: 8.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 661 THKASCDAGPMVASHQ---SPLVSPDPPARGGPSPSPPTAPKALATPAPDTLPVEPGAPSTATASD-ISPGASPSLLSPW 736
Cdd:PRK07764 581 DWQVEAVVGPAPGAAGgegPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGvAAPEHHPKHVAVP 660
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 737 GPWAGSGSISSPGSTGSPLHEEPSPPS-PQNGPGTAVPAPTDFRPSATP-----EDLLASPLSPSEVAAVPPAD-----P 805
Cdd:PRK07764 661 DASDGGDGWPAKAGGAAPAAPPPAPAPaAPAAPAGAAPAQPAPAPAATPpagqaDDPAAQPPQAAQGASAPSPAaddpvP 740
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767923571 806 GPEALHPTVPLDLPPATVPATTFPGAMGSVKPALDWLTREGGELPEADEWTGGDAPAFSTSTLLSGDGDSAELEG 880
Cdd:PRK07764 741 LPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDDEDRRDAEEVAMELLEEELGA 815
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
663-853 |
8.57e-08 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 58.03 E-value: 8.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 663 KASCDAGPMVAShqSPLVSPDPPARGGPSPS------PPTAPKALATPAPDTLPVEPGAPSTATASDISPGASPSLLSPW 736
Cdd:PHA03247 2666 RARRLGRAAQAS--SPPQRPRRRAARPTVGSltsladPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPA 2743
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 737 GPWAGSGSISSPGSTGSPLHEEPSPPSPQNGPGTAVPAPTDFRPSATPEDLLASPLSPSEVAAVPPADPGPEALHPTVPL 816
Cdd:PHA03247 2744 VPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAS 2823
|
170 180 190
....*....|....*....|....*....|....*...
gi 767923571 817 DLPPATVPATTFPGAMGSVK-PALDWLTREGGELPEAD 853
Cdd:PHA03247 2824 PAGPLPPPTSAQPTAPPPPPgPPPPSLPLGGSVAPGGD 2861
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
656-884 |
1.24e-07 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 57.64 E-value: 1.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 656 WQHLCTHKASCDAGpmvashqsplvspDPPARGGPSPSPPTAPKALATPAPDTLPVEPGAPSTATASDISP-GASPSL-L 733
Cdd:PHA03247 2536 WIRGLEELASDDAG-------------DPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPqSARPRApV 2602
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 734 SPWGPWAGSGSISSPGSTGSPLHEEPSPPSP---QNGPGTAVPAPTDFRPSATPEDLLASP------LSPSEVAAVPPAD 804
Cdd:PHA03247 2603 DDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPaanEPDPHPPPTVPPPERPRDDPAPGRVSRprrarrLGRAAQASSPPQR 2682
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 805 PGPEALHPTV---------------PLDLPPATVPAT---TFPGAMGSVKPALDwLTREGGELPEADEWTGGDAPAFSTS 866
Cdd:PHA03247 2683 PRRRAARPTVgsltsladpppppptPEPAPHALVSATplpPGPAAARQASPALP-AAPAPPAVPAGPATPGGPARPARPP 2761
|
250
....*....|....*...
gi 767923571 867 TlLSGDGDSAELEGPPAP 884
Cdd:PHA03247 2762 T-TAGPPAPAPPAAPAAG 2778
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
652-838 |
1.32e-07 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 57.00 E-value: 1.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 652 NWCVWQHLCTHKASCDAGPMVASHQSPLVSPDPPARGGPSPSPPTAPKALATPAPDTLPVEP--GAPSTATASDISPGAS 729
Cdd:PHA03378 665 TWTQIGHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPpaAAPGRARPPAAAPGRA 744
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 730 PsllSPWGPWAGSGSISSPGSTGSPLHEEPSPPSPQNGPgTAVPAPTDfRPSATPEDLLASPLSPSEVAAVPPADPGPEA 809
Cdd:PHA03378 745 R---PPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPP-QAPPAPQQ-RPRGAPTPQPPPQAGPTSMQLMPRAAPGQQG 819
|
170 180 190
....*....|....*....|....*....|...
gi 767923571 810 LHPTVPLDLPPATV----PATTFPGAMGSVKPA 838
Cdd:PHA03378 820 PTKQILRQLLTGGVkrgrPSLKKPAALERQAAA 852
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
681-883 |
1.65e-07 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 56.42 E-value: 1.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 681 SPDPPARGGP--SPSPPTAPKALATPAPDTLPVEPGAPSTATASDISPGASPSLLSPwGPWAGSGSISSPGSTGSPLHEE 758
Cdd:PRK12323 372 AGPATAAAAPvaQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSP-APEALAAARQASARGPGGAPAP 450
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 759 PSPPSPqngpgtaVPAPTDFRPSATPEDLLASPLSPSEVAAvPPADPGPEALHPTVPLDLPPATVPATTFPGAMGSVKPA 838
Cdd:PRK12323 451 APAPAA-------APAAAARPAAAGPRPVAAAAAAAPARAA-PAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWV 522
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 767923571 839 LDWLTREGGELPEADEWTGGDAPAFSTSTLLSGDGDSAELEGPPA 883
Cdd:PRK12323 523 AESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPR 567
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
661-912 |
2.13e-07 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 56.72 E-value: 2.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 661 THKASCDAGPMVASHQSPLVSPDPPARGGPSPSPPT---APKALATPAPDTLPVEPGAPSTATASDISPGASPSLLSPWG 737
Cdd:PHA03307 54 TVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTwslSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPD 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 738 PWAgsgsisspgstgsPLHEEPSPPSPQNGPGTAVPAPTDFRPSATPEDLLASPLSPSEVAAVPPADPGPEALHPTVPLD 817
Cdd:PHA03307 134 LSE-------------MLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPA 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 818 LPPATVPATTFPGAMGSVKPAldwltreggELPEADEWTGGDAPAFSTSTLLSGDGDSAELEGPPAPLILPSSLDYQYDT 897
Cdd:PHA03307 201 AASPRPPRRSSPISASASSPA---------PAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWE 271
|
250
....*....|....*
gi 767923571 898 PGLWELEEATLGASS 912
Cdd:PHA03307 272 ASGWNGPSSRPGPAS 286
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
670-837 |
4.70e-07 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 55.16 E-value: 4.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 670 PMVASHQSPLVSPDPPARGGPSPSPPTAPkalaTPAPDTLPVEPGAPSTATASDISPGASPSLLSPWGPWAGSGSISSPG 749
Cdd:pfam03154 171 PPVLQAQSGAASPPSPPPPGTTQAATAGP----TPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPH 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 750 STGSPLHEEPSPP--SPQ-------NGPGTAVPAPTDFRPSATPEDLLAS-------------PLSPSEVAAV------- 800
Cdd:pfam03154 247 PPLQPMTQPPPPSqvSPQplpqpslHGQMPPMPHSLQTGPSHMQHPVPPQpfpltpqssqsqvPPGPSPAAPGqsqqrih 326
|
170 180 190
....*....|....*....|....*....|....*...
gi 767923571 801 -PPADPGPEALHPTVPLDLPPAtvpattfPGAMGSVKP 837
Cdd:pfam03154 327 tPPSQSQLQSQQPPREQPLPPA-------PLSMPHIKP 357
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
667-820 |
5.53e-07 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 55.33 E-value: 5.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 667 DAGPM-VASHQSPLVSPDP-PARGGPSPSPPTAPKALATPAPDTLPVEPGAPSTATASDISPGASPSLLSPWGPWAGSGS 744
Cdd:PHA03247 2751 PGGPArPARPPTTAGPPAPaPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPP 2830
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767923571 745 ISSPGSTGSPLHEEPSPPSpqNGPGTAVPAPTDFRPSATPEDLLASPLSPSEvaavPPAD--PGPEALHPTVPLDLPP 820
Cdd:PHA03247 2831 PTSAQPTAPPPPPGPPPPS--LPLGGSVAPGGDVRRRPPSRSPAAKPAAPAR----PPVRrlARPAVSRSTESFALPP 2902
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
667-852 |
6.52e-07 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 54.50 E-value: 6.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 667 DAGPmvASHQSPLVSPDPPARGGPSPspptapkalATPAPDTLPVEPGAPSTATASDISPGASPSLLSPwGPWAGSGSIS 746
Cdd:PRK12323 371 GAGP--ATAAAAPVAQPAPAAAAPAA---------AAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSP-APEALAAARQ 438
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 747 SPGSTGSPLHEEPSPPSPQNGPGTAVPAPtdfrPSATPEDLLASPLSPSEVAAVP-PADPGP---EALHPTVPLDLPPAT 822
Cdd:PRK12323 439 ASARGPGGAPAPAPAPAAAPAAAARPAAA----GPRPVAAAAAAAPARAAPAAAPaPADDDPppwEELPPEFASPAPAQP 514
|
170 180 190
....*....|....*....|....*....|
gi 767923571 823 VPATTFPGAMGSVKPALDWLTREGGELPEA 852
Cdd:PRK12323 515 DAAPAGWVAESIPDPATADPDDAFETLAPA 544
|
|
| PRK08691 |
PRK08691 |
DNA polymerase III subunits gamma and tau; Validated |
664-934 |
7.66e-07 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236333 [Multi-domain] Cd Length: 709 Bit Score: 54.33 E-value: 7.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 664 ASCDAGPMVASHQSPLVSPDPPARGGPSPSPPTAPKALATPAPDTLPVEPGAPSTA-TASDISPGASPSLlspwGPWAGS 742
Cdd:PRK08691 364 ASCDANAVIENTELQSPSAQTAEKETAAKKPQPRPEAETAQTPVQTASAAAMPSEGkTAGPVSNQENNDV----PPWEDA 439
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 743 GSISspgstgsplhEEPSPPSP------QNGPGTAVPAPTDFRPSATPEDLLASPLS--PSEVAAVppADPGPEALHPTV 814
Cdd:PRK08691 440 PDEA----------QTAAGTAQtsaksiQTASEAETPPENQVSKNKAADNETDAPLSevPSENPIQ--ATPNDEAVETET 507
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 815 PLDLPPAtvpattfPGAMGSVKPALDWLTREGGELPEADeWTGGdAPAFSTSTLLSGDGDSAELEGPPAPlILPSSLDYQ 894
Cdd:PRK08691 508 FAHEAPA-------EPFYGYGFPDNDCPPEDGAEIPPPD-WEHA-APADTAGGGADEEAEAGGIGGNNTP-SAPPPEFST 577
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 767923571 895 YDTPGLWELEEATLGASSCPCVESV-----QGSTLMPVHVEREIR 934
Cdd:PRK08691 578 ENWAAIVRHFARKLGAAQMPAQHSAwteyhPDTGLMVLAMTAEAR 622
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
670-844 |
1.19e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 54.17 E-value: 1.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 670 PMVASHQSPLvSPDPPARGGPSPSPPTAPKALATPAPDTLPVEPGAPSTATASDISPGASPSLLSPWGPwAGSGSISSPG 749
Cdd:PHA03247 2712 PHALVSATPL-PPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGP-PRRLTRPAVA 2789
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 750 STGSPLHEEPSPPSPQNGPGTAVPAPTDFRPSATPedllASPLSPsevaavppadpgPEALHPTVPldlPPATVPATTFP 829
Cdd:PHA03247 2790 SLSESRESLPSPWDPADPPAAVLAPAAALPPAASP----AGPLPP------------PTSAQPTAP---PPPPGPPPPSL 2850
|
170
....*....|....*
gi 767923571 830 GAMGSVKPALDWLTR 844
Cdd:PHA03247 2851 PLGGSVAPGGDVRRR 2865
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
664-830 |
1.41e-06 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 53.73 E-value: 1.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 664 ASCDAGPMVASHQSPLVSPDPPARGGPSPSPPTAPKALATPAPDTLPVEPGAPSTATASDISPGASPSLLSPWGPWAGSG 743
Cdd:PRK12323 398 APAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAA 477
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 744 SISSPGS---------TGSPLHEEPSPPSPQNGPGTAVPAPTDFRPSATPEDLLASPLSPSEVAAV-PPADPGPEALHPT 813
Cdd:PRK12323 478 AAPARAApaaapapadDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPaPAAAPAPRAAAAT 557
|
170
....*....|....*..
gi 767923571 814 VPldLPPATVPATTFPG 830
Cdd:PRK12323 558 EP--VVAPRPPRASASG 572
|
|
| PSI |
smart00423 |
domain found in Plexins, Semaphorins and Integrins; |
641-677 |
4.49e-06 |
|
domain found in Plexins, Semaphorins and Integrins;
Pssm-ID: 214655 [Multi-domain] Cd Length: 47 Bit Score: 45.61 E-value: 4.49e-06
10 20 30
....*....|....*....|....*....|....*...
gi 767923571 641 CQACVSSRWG-CNWCVWQHLCTHKASCDAGPMVASHQS 677
Cdd:smart00423 8 CSECLLARDPyCAWCSSQGRCTSGERCDSRRQNWLSGG 45
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
664-862 |
4.79e-06 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 51.77 E-value: 4.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 664 ASCDAGPMVASHQSPLVSPDPPARGGPSPSPPTAPKALATPAPDTLPVEPGAPSTATASdiSPGASPSLLSPWGPWAGSG 743
Cdd:PRK07003 392 GASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVP--AKANARASADSRCDERDAQ 469
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 744 SISSPGSTGSPLHEEPSPPSPQNGPGTAVPAPTDFRPSATPEDLLASPLsPSEVAavPPADPGPEALHPTvpldlPPATV 823
Cdd:PRK07003 470 PPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASR-EDAPA--AAAPPAPEARPPT-----PAAAA 541
|
170 180 190
....*....|....*....|....*....|....*....
gi 767923571 824 PATTFPGAMGsvkpALDWLtREGGELPEADEWTGGDAPA 862
Cdd:PRK07003 542 PAARAGGAAA----ALDVL-RNAGMRVSSDRGARAAAAA 575
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
675-824 |
6.57e-06 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 51.69 E-value: 6.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 675 HQSPLVSPDPPARGGPSPSPP--TAPKALATPA-------------------PDTLPVEP-GAPSTATASDISPGASPSL 732
Cdd:pfam03154 238 HPQRLPSPHPPLQPMTQPPPPsqVSPQPLPQPSlhgqmppmphslqtgpshmQHPVPPQPfPLTPQSSQSQVPPGPSPAA 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 733 LSPWGPWAGSGSISSPGSTGSPLHEEPSPPSPQNGPGTAVPAPTDFRPSATPEdllaSPLSPSEVAAVPPAD-----PGP 807
Cdd:pfam03154 318 PGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQ----SHKHPPHLSGPSPFQmnsnlPPP 393
|
170
....*....|....*....
gi 767923571 808 EALHP--TVPLDLPPATVP 824
Cdd:pfam03154 394 PALKPlsSLSTHHPPSAHP 412
|
|
| Sema_5B |
cd11264 |
The Sema domain, a protein interacting module, of semaphorin 5B (Sema5B); Sema5B is expressed ... |
37-255 |
6.82e-06 |
|
The Sema domain, a protein interacting module, of semaphorin 5B (Sema5B); Sema5B is expressed in regions of the basal telencephalon in rat. Sema5B is an inhibitory cue for corticofugal axons and acts as a source of repulsion for the appropriate guidance of cortical axons away from structures such as the ventricular zone as they navigate toward and within subcortical regions. In addition to its role as a guidance cue, Sema5B regulates the development and maintenance of synapse size and number in hippocampal neurons. In addition, the sema domain of Sema5B can be cleaved of the whole protein and exerts its function in regulation of synapse morphology. Sema5B belongs to the class 5 semaphorin family of proteins, which are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.
Pssm-ID: 200525 [Multi-domain] Cd Length: 437 Bit Score: 50.75 E-value: 6.82e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 37 HLARDPTSGTLYLGATNFLFQLS-PGLQLEATVSTGPVLDS-RDCLPP-VMPDECpqaqptNNPNQLLLVSPGALVVCGS 113
Cdd:cd11264 11 QLALDLNRNQLIVGARNYLFRLSlHNVSLIQATEWGSDEDTrRSCQSKgKTEEEC------QNYVRVLIVYGKKVFTCGT 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 114 -VHQGVCEQRRLGQLEQLLLRPERPGDTQYvaanDPA-VSTVGLVAQG--LAGEPLLFVGRGYTSRGVGGGIPPITT--- 186
Cdd:cd11264 85 nAFSPVCTSRQVGNLSKVIERINGVARCPY----DPRhNSTAVITSRGelYAATVIDFSGRDPAIYRSLGSVPPLRTaqy 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767923571 187 RALWPPDPqaafsyeetaklavgrlseyshHFVSAFARGASAYFlFLRRDLQAQS--RAFRAYVSRVCLRD 255
Cdd:cd11264 161 NSKWLNEP----------------------NFIAAYDIGLFTYF-FFRENAVEHDcgKTVYSRVARVCKND 208
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
668-884 |
8.18e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 51.48 E-value: 8.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 668 AGPMVASHQSPLVSPDPPARGGPSPSPPTAPKALATPAPDTL-----PVEPGAPSTA---TASDISPGASPSLLSPWGPW 739
Cdd:PHA03247 2777 AGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALppaasPAGPLPPPTSaqpTAPPPPPGPPPPSLPLGGSV 2856
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 740 AGSGSISSPGSTGSPLheePSPPSPQNGPGTAVPAPTdfrPSATPEDLLASPLSPSEvaavPPADPGPEALHPTVPLDLP 819
Cdd:PHA03247 2857 APGGDVRRRPPSRSPA---AKPAAPARPPVRRLARPA---VSRSTESFALPPDQPER----PPQPQAPPPPQPQPQPPPP 2926
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767923571 820 PATVPATTFPGAMGS-VKPALDWLTREGGELPEADEWTGGDAPA--FSTSTLLSGDGDSAELEGPPAP 884
Cdd:PHA03247 2927 PQPQPPPPPPPRPQPpLAPTTDPAGAGEPSGAVPQPWLGALVPGrvAVPRFRVPQPAPSREAPASSTP 2994
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
673-889 |
1.59e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 50.71 E-value: 1.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 673 ASHQSPLVSPDPPARGGPSPSPPTAPKALATPAPDTLPVEPGA----PSTAT--------ASDISpGASPSLLSPWGPwa 740
Cdd:PHA03247 2484 AEARFPFAAGAAPDPGGGGPPDPDAPPAPSRLAPAILPDEPVGepvhPRMLTwirgleelASDDA-GDPPPPLPPAAP-- 2560
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 741 gsgsisspgstgsPLHEEPSPPSPQNGPGTAVPAPT--DFRPSATPEDllASPLSPSEVAAVPPADPGPEALHPTVPLDL 818
Cdd:PHA03247 2561 -------------PAAPDRSVPPPRPAPRPSEPAVTsrARRPDAPPQS--ARPRAPVDDRGDPRGPAPPSPLPPDTHAPD 2625
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767923571 819 PPATVPAttfpgAMGSVKPALDWLTREGGELPEADEWTGGDAPAFSTSTLLSGDGDSAELEGPPAPLILPS 889
Cdd:PHA03247 2626 PPPPSPS-----PAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPT 2691
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
673-891 |
1.91e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 50.32 E-value: 1.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 673 ASHQSPLVSPDPPARGGPSPSPPTAPkALATPAPDTLPVEPGA--PSTATASDISPGAS--------PSLLSPWGPWAGS 742
Cdd:PHA03247 2620 DTHAPDPPPPSPSPAANEPDPHPPPT-VPPPERPRDDPAPGRVsrPRRARRLGRAAQASsppqrprrRAARPTVGSLTSL 2698
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 743 GSISSPGSTGSP-----LHEEPSPPSPQNGPGTAVPAPTDFRPSATPEDlLASPLSPSEVAAvPPADPGPEAlhPTVPLD 817
Cdd:PHA03247 2699 ADPPPPPPTPEPaphalVSATPLPPGPAAARQASPALPAAPAPPAVPAG-PATPGGPARPAR-PPTTAGPPA--PAPPAA 2774
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767923571 818 lPPATVPATTFPGAMGSVKPALDWLTREGGELPEADEWTGGDA---PAFSTSTLLSGDGDSAELEGPPAPLILPSSL 891
Cdd:PHA03247 2775 -PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAalpPAASPAGPLPPPTSAQPTAPPPPPGPPPPSL 2850
|
|
| Sema_5 |
cd11241 |
The Sema domain, a protein interacting module, of semaphorin 5 (Sema5); Class 5 semaphorins ... |
32-255 |
1.95e-05 |
|
The Sema domain, a protein interacting module, of semaphorin 5 (Sema5); Class 5 semaphorins are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. There are three subfamilies in class 5 semaphorins, namely 5A, 5B and 5C. Sema5A and Sema5B function as guidance cues for optic and corticofugal nerve development, respectively. Sema5A-induced cell migration requires Met signaling. Sema5C is an early development gene and may play a role in odor-guided behavior. Sema5A is also implicated in cancer. In a screening model for metastasis, the Drosophila Sema5A ortholog, Dsema-5C, has been found to be required in tumorigenicity and metastasis. Sema5A is highly expressed in human pancreatic cancer cells and is associated with tumor growth, invasion and metastasis. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.
Pssm-ID: 200502 [Multi-domain] Cd Length: 438 Bit Score: 49.47 E-value: 1.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 32 GTYLQHLArDPTSGTLYLGATNFLFQLSpgLQ----LEATVSTGPVLDSRDC-LPPVMPDECpqaqptNNPNQLLLVSPG 106
Cdd:cd11241 7 SDFSRLVL-DPTHDQLIVGARNYLFRLR--LQslslLQAVPWNSDEDTKRQCqSKGKSVEEC------QNYVRVLLVVGK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 107 ALVVCGS-VHQGVCEQRRLGQLEQLLLRPERPGDTQYvaanDPAV-STVGLVAQG--LAGEPLLFVGRGYTSRGVGGGIP 182
Cdd:cd11241 78 NLFTCGTyAFSPVCTIRKLSNLTQILDTISGVARCPY----SPAHnSTALISASGelYAGTVYDFSGRDPAIYRSLGGKP 153
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767923571 183 PITTR---ALWPPDPQaafsyeetaklavgrlseyshhFVSAFARGASAYFLFLRRDLQAQSRAFRAY--VSRVCLRD 255
Cdd:cd11241 154 PLRTAqynSKWLNEPN----------------------FVGSYEIGNHTYFFFRENAVEHQDCGKTVYsrIARVCKND 209
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
681-838 |
1.97e-05 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 49.85 E-value: 1.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 681 SPDPPARGGPSPSPPTAPKALATPAPDTLPV-----EPGAPSTATASDISPGASPSLLSPWGPWAGSGSISSPGSTGSPL 755
Cdd:PRK07003 372 VPARVAGAVPAPGARAAAAVGASAVPAVTAVtgaagAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPA 451
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 756 HEE-PSPPSPQNGPGTAVPaPTDFRPSATPEDlLASPLSPSEVAavPPADPGPEALHPTVPLDLPPATVPATTFPGAMGS 834
Cdd:PRK07003 452 KANaRASADSRCDERDAQP-PADSGSASAPAS-DAPPDAAFEPA--PRAAAPSAATPAAVPDARAPAAASREDAPAAAAP 527
|
....
gi 767923571 835 VKPA 838
Cdd:PRK07003 528 PAPE 531
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
676-895 |
2.83e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.55 E-value: 2.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 676 QSPLVSPDPPARGGPSPSPPTAPKALATPAPDTLPVEPGAPSTATASdiSPGASPSLLSPWgpwagsgsissPGSTGSPL 755
Cdd:PHA03247 2905 PERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAG--AGEPSGAVPQPW-----------LGALVPGR 2971
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 756 HEEPSPPSPQNGPGTAVPAPtdfrPSATPEDLLASPLS--PSEVAAVPPADPGPEALHPT--VPLDLPPATVPATTFPGA 831
Cdd:PHA03247 2972 VAVPRFRVPQPAPSREAPAS----STPPLTGHSLSRVSswASSLALHEETDPPPVSLKQTlwPPDDTEDSDADSLFDSDS 3047
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767923571 832 MGSVKPALDwltreggelPEADEWTGGDAPAFSTSTLLSGDGDSAELEGPPAPLILPSSLDYQY 895
Cdd:PHA03247 3048 ERSDLEALD---------PLPPEPHDPFAHEPDPATPEAGARESPSSQFGPPPLSANAALSRRY 3102
|
|
| PSI |
pfam01437 |
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ... |
1021-1061 |
2.88e-05 |
|
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).
Pssm-ID: 396154 [Multi-domain] Cd Length: 52 Bit Score: 43.47 E-value: 2.88e-05
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 767923571 1021 DCSvGHGDCSRCQTAmPQYGCVWCEGERpRCVTREACGEAE 1061
Cdd:pfam01437 1 RCS-QYTSCSSCLAA-RDPYCGWCSSEG-RCVRRSACGAPE 38
|
|
| PLN03209 |
PLN03209 |
translocon at the inner envelope of chloroplast subunit 62; Provisional |
684-830 |
5.27e-05 |
|
translocon at the inner envelope of chloroplast subunit 62; Provisional
Pssm-ID: 178748 [Multi-domain] Cd Length: 576 Bit Score: 48.38 E-value: 5.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 684 PPArgGPSPSPPTAPKALATP-----APDTLPVEPGAPSTATASDISPGASPSLLS-PWGPWAGsgsisspgstgsplHE 757
Cdd:PLN03209 382 PPT--SPIPTPPSSSPASSKSvdavaKPAEPDVVPSPGSASNVPEVEPAQVEAKKTrPLSPYAR--------------YE 445
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767923571 758 EPSPP-SPQNGPGTAVPAPTDFRPSATPEDLLASPLSPSEVAAVPPADPGPEALHPtVPLDLPPATVPATTFPG 830
Cdd:PLN03209 446 DLKPPtSPSPTAPTGVSPSVSSTSSVPAVPDTAPATAATDAAAPPPANMRPLSPYA-VYDDLKPPTSPSPAAPV 518
|
|
| KLF9_13_N-like |
cd21975 |
Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like ... |
680-826 |
5.44e-05 |
|
Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the related N-terminal domains of KLF9, KLF13, KLF14, KLF16, and similar proteins.
Pssm-ID: 409240 [Multi-domain] Cd Length: 163 Bit Score: 45.84 E-value: 5.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 680 VSPDPPARGGPSPSPPTAPKA-LATPAPDTLPVEPGAPSTATASdispGASPSLL--SPWGPWAGSGSISSPGSTGSPLH 756
Cdd:cd21975 21 VRPDPEGAGLAAGLDVRATREvAKGPGPPGPAWKPDGADSPGLV----TAAPHLLaaNVLAPLRGPSVEGSSLESGDADM 96
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 757 EEPSPPSPQngPGTAvpaptdfrPSATPEDLLASPLSPSEVAAVPPADPGPEALHPTVPLDLPPATVPAT 826
Cdd:cd21975 97 GSDSDVAPA--SGAA--------ASTSPESSSDAASSPSPLSLLHPGEAGLEPERPRPRVRRGVRRRGVT 156
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
682-807 |
5.78e-05 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 48.44 E-value: 5.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 682 PDPPARGGPSPSPPTAPKALATPAPDTLPVEPGAPSTATASDISPGASPSllspwgpwagsGSISSPGSTGSPLHEEPSP 761
Cdd:PRK07764 393 APAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPP-----------SPAGNAPAGGAPSPPPAAA 461
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 767923571 762 PSPQNGPGTAVPAPTDFRPSATPEDLLASPLSPsEVAAVPPADPGP 807
Cdd:PRK07764 462 PSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAP-AAPAAPAAPAGA 506
|
|
| PLN03209 |
PLN03209 |
translocon at the inner envelope of chloroplast subunit 62; Provisional |
666-884 |
6.04e-05 |
|
translocon at the inner envelope of chloroplast subunit 62; Provisional
Pssm-ID: 178748 [Multi-domain] Cd Length: 576 Bit Score: 48.00 E-value: 6.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 666 CDAGPMVASHQSPLVSPDPPARGGPSPS-PPTAPKALATPAP-DTLPVEPGAPSTAtaSDISP----GASPSLLSPWGPW 739
Cdd:PLN03209 300 CKVVEVIAETTAPLTPMEELLAKIPSQRvPPKESDAADGPKPvPTKPVTPEAPSPP--IEEEPpqpkAVVPRPLSPYTAY 377
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 740 AGSgsisspgstgsplhEEPSPPSPqNGPGTAVPAPTDFRPSATPE--DLLASPLSPSEVAAVPPADPGPEALHPTVPL- 816
Cdd:PLN03209 378 EDL--------------KPPTSPIP-TPPSSSPASSKSVDAVAKPAepDVVPSPGSASNVPEVEPAQVEAKKTRPLSPYa 442
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767923571 817 ---DLPPATVPATTFPGAMGSVKPALDWLTREGGELPeADEWTGGDAPAFSTSTLLSGDGDSAELEGPPAP 884
Cdd:PLN03209 443 ryeDLKPPTSPSPTAPTGVSPSVSSTSSVPAVPDTAP-ATAATDAAAPPPANMRPLSPYAVYDDLKPPTSP 512
|
|
| PSI |
smart00423 |
domain found in Plexins, Semaphorins and Integrins; |
1021-1068 |
6.68e-05 |
|
domain found in Plexins, Semaphorins and Integrins;
Pssm-ID: 214655 [Multi-domain] Cd Length: 47 Bit Score: 42.15 E-value: 6.68e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 767923571 1021 DCSVgHGDCSRCQTAMPQYgCVWCEGERpRCVTREACGE--AEAVATQCP 1068
Cdd:smart00423 1 RCSK-YTSCSECLLARDPY-CAWCSSQG-RCTSGERCDSrrQNWLSGGCP 47
|
|
| RasGAP |
cd04519 |
Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is ... |
1614-1724 |
1.16e-04 |
|
Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin, among others. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP exhibit no similarity at their amino acid sequence level. RasGTPases function as molecular switches in a large number of signaling pathways. They are in the on state when bound to GTP, and in the off state when bound to GDP. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.
Pssm-ID: 213328 Cd Length: 256 Bit Score: 45.95 E-value: 1.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1614 LFLTKFIHTLESQ--RTFSARDRAYVASLLTVALHGKlEYFTDILRTLLSDLVAQyvAKNPKLMLRRTeTVVEKLLTNWM 1691
Cdd:cd04519 8 LLLTESPLALLRElsQVLPVKDKEEVATALLRIFESR-GLALEFLRYLVRSEVKN--TKNPNTLFRGN-SLATKLLDQYM 83
|
90 100 110
....*....|....*....|....*....|...
gi 767923571 1692 SICLYTFVRDSVGEPLYMLFRGIKHQVDKGPVD 1724
Cdd:cd04519 84 KLVGQEYLKETLSPLIREILESKESCEIDTKLP 116
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
681-825 |
1.38e-04 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 47.02 E-value: 1.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 681 SPDPPARGGPSPSPPTAPKALATPAPdtlpVEPGAPSTATASdisPGASPSllSPWGPWAGSGSISSPGSTGSPLHEEPS 760
Cdd:PRK14951 380 TPARPEAAAPAAAPVAQAAAAPAPAA----APAAAASAPAAP---PAAAPP--APVAAPAAAAPAAAPAAAPAAVALAPA 450
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767923571 761 PPSPQNGPGTAVPAPTDFRPsatpedllasplSPSEVAAVPPADPGPEALHPTVPLDLPPATVPA 825
Cdd:PRK14951 451 PPAQAAPETVAIPVRVAPEP------------AVASAAPAPAAAPAAARLTPTEEGDVWHATVQQ 503
|
|
| Sema_6 |
cd11242 |
The Sema domain, a protein interacting module, of class 6 semaphorins (Sema6); Class 6 ... |
217-443 |
1.61e-04 |
|
The Sema domain, a protein interacting module, of class 6 semaphorins (Sema6); Class 6 semaphorins (Sema6s) are membrane associated semaphorins. There are 6 subfamilies named 6A to 6D. Sema6s bind to plexin As in a neuropilin independent fashion. Sema6-plexin A signaling plays important roles in lamina-specific axon projections. Interactions between plexin A2, plexin A4, and Sema6A control lamina-restricted projection of hippocampal mossy fibers. Interactions between Sema6C, Sema6D and plexin A1 shape the stereotypic trajectories of sensory axons in the spinal cord. In addition to axon targeting, Sema6D-plexin A1 interactions influence a wide range of other biological processes. During cardiac development, Sema6D attracts or repels endothelial cells in the cardiac tube depending on the expression patterns of specific coreceptors in addition to plexin A1. Furthermore, Sema6D binds a receptor complex comprising of plexin A1, Trem2 (triggering receptor expressed on myeloid cells 2), and DAP12 on dendritic cells and osteoclasts to mediate T-cell-DC interactions and to control bone development, respectively. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.
Pssm-ID: 200503 [Multi-domain] Cd Length: 465 Bit Score: 46.74 E-value: 1.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 217 HFVSAFARGASAYFLFlrRDLQAQ----SRAFRAYVSRVCLRD---------QHYYSYVELPLACE--GGR---YGLIQa 278
Cdd:cd11242 174 HFVHAVEYGDYVYFFF--REIAVEyntlGKVVFSRVARVCKNDmggsprvleKQWTSFLKARLNCSvpGDShfyFDVLQ- 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 279 aAVATSREVAHGEVLFAAFSSAAPPTVGrppsaaagasgaSALCAFPLDEVDRLAN------RTRDACYT---------- 342
Cdd:cd11242 251 -AVTDVIRINGRPVVLGVFTTQYNSIPG------------SAVCAFDMDDIEKVFEgrfkeqKSPDSAWTpvpedrvpkp 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 343 REGR-AEDGTEVAYieydvnSDCAQLPVDTLD---AYPCgsdhtpspMASRVPleatPILEWPGI-------QLTAVAVT 411
Cdd:cd11242 318 RPGCcAGSGSAEKY------KTSNDFPDDTLNfikTHPL--------MDEAVP----SIINRPWFtrtmvryRLTQIAVD 379
|
250 260 270
....*....|....*....|....*....|....*.
gi 767923571 412 MEDG----HTIAFLGDSQGQLHRVYLGPGSDGHPYS 443
Cdd:cd11242 380 NAAGpyqnYTVVFLGSEAGTVLKFLARIGPSGSNGS 415
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
668-781 |
1.89e-04 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 46.63 E-value: 1.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 668 AGPMVASHQSPLVSPDPPARGGPSPSPPtaPKALATPAPDTLPVEPGAPSTATASDISPGASPSLLSPWGPWAGSGSISS 747
Cdd:PRK14951 379 KTPARPEAAAPAAAPVAQAAAAPAPAAA--PAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQAA 456
|
90 100 110
....*....|....*....|....*....|....*
gi 767923571 748 PGSTGSPLHEEPSPPSPQNGPG-TAVPAPTDFRPS 781
Cdd:PRK14951 457 PETVAIPVRVAPEPAVASAAPApAAAPAAARLTPT 491
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
661-882 |
2.69e-04 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 46.06 E-value: 2.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 661 THKASCDAGPmvashQSPLVSPDPPARGGPSPSPPTA-PKALATPAPDTLPVEPGaPSTATASDISP-------GASPSL 732
Cdd:pfam05109 416 THKVIFSKAP-----ESTTTSPTLNTTGFAAPNTTTGlPSSTHVPTNLTAPASTG-PTVSTADVTSPtpagttsGASPVT 489
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 733 LSPwGPwAGSGSISSPGSTGSPLHEEPSPPSPQNGPGTAVPAPTdfrPSATPEDLlaSPLSPSEVAAVPpaDPGPEALHP 812
Cdd:pfam05109 490 PSP-SP-RDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTTPT---PNATSPTL--GKTSPTSAVTTP--TPNATSPTP 560
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767923571 813 TVPLDLPPATVPattfpgAMGSVKPALDWLTreggELPEADEWTGGDAP--AFSTSTLLSGDGDSAELEGPP 882
Cdd:pfam05109 561 AVTTPTPNATIP------TLGKTSPTSAVTT----PTPNATSPTVGETSpqANTTNHTLGGTSSTPVVTSPP 622
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
678-879 |
4.63e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 45.61 E-value: 4.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 678 PLVSPDPPARGGPSPSPP---TAPKALATPAPDTLPVEPGAPSTATASDispGASPSLLSPwgpwAGSGSISSPGSTGSP 754
Cdd:PRK07003 360 PAVTGGGAPGGGVPARVAgavPAPGARAAAAVGASAVPAVTAVTGAAGA---ALAPKAAAA----AAATRAEAPPAAPAP 432
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 755 LHEEPSPPSPQNGPGTA-VPAPTDFRPSATPEDLLASPLSPSEVAAVPPAD-PGPEALHPTVPLDLPPATVPATTFPGAM 832
Cdd:PRK07003 433 PATADRGDDAADGDAPVpAKANARASADSRCDERDAQPPADSGSASAPASDaPPDAAFEPAPRAAAPSAATPAAVPDARA 512
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 767923571 833 GSVKPALDWLTREGGELPEAdewtGGDAPAFSTSTLLSGdGDSAELE 879
Cdd:PRK07003 513 PAAASREDAPAAAAPPAPEA----RPPTPAAAAPAARAG-GAAAALD 554
|
|
| Gag_spuma |
pfam03276 |
Spumavirus gag protein; |
670-839 |
7.35e-04 |
|
Spumavirus gag protein;
Pssm-ID: 460872 [Multi-domain] Cd Length: 614 Bit Score: 44.74 E-value: 7.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 670 PMVASHQSPLVSPDPPARGGPSPSPPTA---PKALATPAPDTLPVEPGAPSTATASDISPGASPSLLSPWGPWAGSGSIS 746
Cdd:pfam03276 187 PPGASFSGLPSLPAIGGIHLPAIPGIHArapPGNIARSLGDDIMPSLGDAGMPQPRFAFHPGNPFAEAEGHPFAEAEGER 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 747 SPGSTGSPLHEEPSPPSPqngpgtavPAPtdfRPSATPEDLLASPLSPSEVAAVPPADP--GPEALHPTVPLDLPPAT-V 823
Cdd:pfam03276 267 PRDIPRAPRIDAPSAPAI--------PAI---QPIAPPMIPPIGAPIPIPHGASIPGEHirNPREEPIRLGREAPAIDgR 335
|
170
....*....|....*.
gi 767923571 824 PATTFPGAMGSVKPAL 839
Cdd:pfam03276 336 FAPAIDDLFCRIINAL 351
|
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
678-898 |
9.60e-04 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 44.30 E-value: 9.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 678 PLVSPDPPARGGP-SPSPPTAPKALATPAPDTLPVEPGAPSTATASDI--SPGASPSLLSPWGPWAGSGSISSPGSTGSP 754
Cdd:PTZ00449 573 PTLSKKPEFPKDPkHPKDPEEPKKPKRPRSAQRPTRPKSPKLPELLDIpkSPKRPESPKSPKRPPPPQRPSSPERPEGPK 652
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 755 LHEEPSPP-SPQngpgtaVPAPTDFR----------PSATPEDLLASPLSPSEVAAVPPADPGPEALHPTVPLDLPPA-- 821
Cdd:PTZ00449 653 IIKSPKPPkSPK------PPFDPKFKekfyddyldaAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKlp 726
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 822 TVPATTF--PGAMGSVKPAldwlTREGGELPEAD----EWTGGDAPAFSTSTLLSGDGD-SAELEGPPAPLILPSSLDYQ 894
Cdd:PTZ00449 727 RDEEFPFepIGDPDAEQPD----DIEFFTPPEEErtffHETPADTPLPDILAEEFKEEDiHAETGEPDEAMKRPDSPSEH 802
|
....
gi 767923571 895 YDTP 898
Cdd:PTZ00449 803 EDKP 806
|
|
| PHA02682 |
PHA02682 |
ORF080 virion core protein; Provisional |
674-815 |
1.23e-03 |
|
ORF080 virion core protein; Provisional
Pssm-ID: 177464 [Multi-domain] Cd Length: 280 Bit Score: 43.31 E-value: 1.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 674 SHQSPLvSPDP----PARGGPSPSPPTAPKALATPAPdtlpvepgapstatasdiSPGASPSLLSPWGPWAGSGSISSPG 749
Cdd:PHA02682 77 SGQSPL-APSPacaaPAPACPACAPAAPAPAVTCPAP------------------APACPPATAPTCPPPAVCPAPARPA 137
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767923571 750 STGSPLHEE--PSPPSPQNGPGTAVpAPTDFRPSATPEDLLASPLSPSEVAavPPADPgpeALHPTVP 815
Cdd:PHA02682 138 PACPPSTRQcpPAPPLPTPKPAPAA-KPIFLHNQLPPPDYPAASCPTIETA--PAASP---VLEPRIP 199
|
|
| KREPA2 |
cd23959 |
Kinetoplastid RNA Editing Protein A2 (KREPA2); The KREPA2 (TbMP63) protein is a component of ... |
685-838 |
1.70e-03 |
|
Kinetoplastid RNA Editing Protein A2 (KREPA2); The KREPA2 (TbMP63) protein is a component of the parasitic protozoan's KREPA RNA editing catalytic complex (RECC). Kinetoplastid RNA editing (KRE) proteins occur as pairs or sets of related proteins in multiple complexes. KREPA complex is composed of six components (KREPA1-6), which share a conserved C-terminal region containing an oligonucleotide-binding (OB)-fold-like domain. KREPAs are responsible for the site-specific insertion and deletion of U nucleotides in the kinetoplastid mitochondria pre-messenger RNA. Apart from the conserved C-terminal OB-fold domain, KREPA1, KREPA2, and KREPA3 contain two conserved C2H2 zinc-finger domains. KREPA2 and kinetoplastid RNA editing ligase 1 (KREL1) are specific for ligation post-U-deletion and are paralogous to KREL2 and KREPA1 that are specific for ligation post-U-insertion. KREPA2, is critical for RECC stability and KREL1 integration into the complex.
Pssm-ID: 467780 [Multi-domain] Cd Length: 424 Bit Score: 43.32 E-value: 1.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 685 PARGGPSPSPPTAPKALATPAPDTLPVEP------GAPSTATASDISPGASPsllspwgpwagsgsisspgstgsplheE 758
Cdd:cd23959 109 PFRAARVPNPFSASSSTQRETHKTAQVAPpkaepqTAPVTPFGQLPMFGQHP---------------------------P 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 759 PSPPSPQNGPGTAVPAPTDFrpsatpedlLASPLSPSEVAAVPPADPGPEALHPTVPLDLPP-ATVPATTFPGAMGSVKP 837
Cdd:cd23959 162 PAKPLPAAAAAQQSSASPGE---------VASPFASGTVSASPFATATDTAPSSGAPDGFPAeASAPSPFAAPASAASFP 232
|
.
gi 767923571 838 A 838
Cdd:cd23959 233 A 233
|
|
| IPT_plexin_repeat2 |
cd01179 |
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ... |
1252-1374 |
1.81e-03 |
|
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.
Pssm-ID: 238584 Cd Length: 85 Bit Score: 39.13 E-value: 1.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 1252 PNITSAGPTKSFLSGGREICVRGQNLDVvqtprirvtvvsrmlqpsqglGRRRRVvpetacSLGpscssqqfEEPCH--- 1328
Cdd:cd01179 1 PSITSLSPSYGPQSGGTRLTITGKHLNA---------------------GSSVRV------TVG--------GQPCKils 45
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 767923571 1329 VNSSQlITCRTPALPGLPEdpwVRVEfildnLVFDFA-TLNPTPFSY 1374
Cdd:cd01179 46 VSSSQ-IVCLTPPSASPGE---APVK-----VLIDGArRLAPLVFTY 83
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
681-823 |
3.22e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 42.67 E-value: 3.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 681 SPDPPARGGPSPSPPTAPKAlATPAPDTLPVEPGAPSTATASDISPGASPSllspwgpwagsgsisspgSTGSPLHEEPS 760
Cdd:PRK07764 393 APAAAAPSAAAAAPAAAPAP-AAAAPAAAAAPAPAAAPQPAPAPAPAPAPP------------------SPAGNAPAGGA 453
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767923571 761 PPSPQNGPGTAVPAPTdfrPSATPEDLLASPLSPSEVAAvPPADPGPEALHPTVPLDLPPATV 823
Cdd:PRK07764 454 PSPPPAAAPSAQPAPA---PAAAPEPTAAPAPAPPAAPA-PAAAPAAPAAPAAPAGADDAATL 512
|
|
| PRK14950 |
PRK14950 |
DNA polymerase III subunits gamma and tau; Provisional |
759-862 |
3.26e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237864 [Multi-domain] Cd Length: 585 Bit Score: 42.49 E-value: 3.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 759 PSPPSPQNGPGTAVPAPTdfRPSATPedllASPLSPSEVAAVPPADPGPEALHPTV--------PLDLPPATVPATTFPG 830
Cdd:PRK14950 362 PVPAPQPAKPTAAAPSPV--RPTPAP----STRPKAAAAANIPPKEPVRETATPPPvpprpvapPVPHTPESAPKLTRAA 435
|
90 100 110
....*....|....*....|....*....|..
gi 767923571 831 AMGSVKPALDwltregGELPEADEWTGGDAPA 862
Cdd:PRK14950 436 IPVDEKPKYT------PPAPPKEEEKALIADG 461
|
|
| PSI |
pfam01437 |
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ... |
641-666 |
3.64e-03 |
|
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).
Pssm-ID: 396154 [Multi-domain] Cd Length: 52 Bit Score: 37.30 E-value: 3.64e-03
10 20
....*....|....*....|....*..
gi 767923571 641 CQACVSSR-WGCNWCVWQHLCTHKASC 666
Cdd:pfam01437 8 CSSCLAARdPYCGWCSSEGRCVRRSAC 34
|
|
| half-pint |
TIGR01645 |
poly-U binding splicing factor, half-pint family; The proteins represented by this model ... |
696-880 |
5.37e-03 |
|
poly-U binding splicing factor, half-pint family; The proteins represented by this model contain three RNA recognition motifs (rrm: pfam00076) and have been characterized as poly-pyrimidine tract binding proteins associated with RNA splicing factors. In the case of PUF60 (GP|6176532), in complex with p54, and in the presence of U2AF, facilitates association of U2 snRNP with pre-mRNA.
Pssm-ID: 130706 [Multi-domain] Cd Length: 612 Bit Score: 41.98 E-value: 5.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 696 TAPKALATPA-PDTLPVEPG---APSTA--TASDISPGAS---PSLLSPWGPWAGSGSISSPGSTGSPLHEEPS--PPSP 764
Cdd:TIGR01645 283 TPPDALLQPAtVSAIPAAAAvaaAAATAkiMAAEAVAGAAvlgPRAQSPATPSSSLPTDIGNKAVVSSAKKEAEevPPLP 362
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 765 QNGPGTAVPAPTDFrPSATPEDLLASPLSPSEVAAVPPADPGPEAL-HPTVPLDLppatvpaTTFPGAMGSVKPALDWLT 843
Cdd:TIGR01645 363 QAAPAVVKPGPMEI-PTPVPPPGLAIPSLVAPPGLVAPTEINPSFLaSPRKKMKR-------EKLPVTFGALDDTLAWKE 434
|
170 180 190
....*....|....*....|....*....|....*..
gi 767923571 844 REGGELPEADEWTGGDAPAFSTSTLLSGDGDSAELEG 880
Cdd:TIGR01645 435 PSKEDQTSEDGKMLAIMGEAAAALALEPKKKKKEKEG 471
|
|
| PTZ00436 |
PTZ00436 |
60S ribosomal protein L19-like protein; Provisional |
657-829 |
5.66e-03 |
|
60S ribosomal protein L19-like protein; Provisional
Pssm-ID: 185616 [Multi-domain] Cd Length: 357 Bit Score: 41.47 E-value: 5.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 657 QHLCTHKASCDAGPMVASHQSPLVSPDPPARGGPSPSPPTAPKALATPAPDTLPVEPGAPSTATASDISPGASPSllspw 736
Cdd:PTZ00436 201 QKAAAKKAAAPSGKKSAKAAAPAKAAAAPAKAAAPPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAAAPPAKAA----- 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 737 gpwagsgsisspgstGSPLHEEPSPPSPQNGPGTAVPAPTdfRPSATPEDLLASPlspSEVAAVPPADPGPEALHPTVPL 816
Cdd:PTZ00436 276 ---------------APPAKAAAPPAKAAAPPAKAAAAPA--KAAAAPAKAAAAP---AKAAAPPAKAAAPPAKAATPPA 335
|
170
....*....|...
gi 767923571 817 DLPPATVPATTFP 829
Cdd:PTZ00436 336 KAAAPPAKAAAAP 348
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
684-839 |
5.70e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 42.23 E-value: 5.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 684 PPARGGPSPSPPTAPKALATPAPDTLPvEPgAPSTATASDISPGASPSLLSPWGPWAGSGSISSPGSTGSPLHEEPSPPS 763
Cdd:PHA03247 2861 DVRRRPPSRSPAAKPAAPARPPVRRLA-RP-AVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR 2938
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767923571 764 PQNgpgtavPAPTDFRPSATPEDLLASPlSPSEVAAVPPADPGPEALhptVPLDLPPATVPATTFPGAMGSVKPAL 839
Cdd:PHA03247 2939 PQP------PLAPTTDPAGAGEPSGAVP-QPWLGALVPGRVAVPRFR---VPQPAPSREAPASSTPPLTGHSLSRV 3004
|
|
| PHA03201 |
PHA03201 |
uracil DNA glycosylase; Provisional |
759-841 |
8.39e-03 |
|
uracil DNA glycosylase; Provisional
Pssm-ID: 165468 Cd Length: 318 Bit Score: 40.65 E-value: 8.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923571 759 PSPPSPQNGPGTAVPAPTDFRPSATPEDLLASPLSPSEVAAVPPADP--GPEALHPTVPLDLPPATVPATTFPGAMGSVK 836
Cdd:PHA03201 9 PSPPRRPSPPRPTPPRSPDASPEETPPSPPGPGAEPPPGRAAGPAAPrrRPRGCPAGVTFSSSAPPRPPLGLDDAPAATP 88
|
....*
gi 767923571 837 PALDW 841
Cdd:PHA03201 89 PPLDW 93
|
|
|