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Conserved domains on  [gi|767977912|ref|XP_011533465|]
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RING finger protein 17 isoform X11 [Homo sapiens]

Protein Classification

tudor domain-containing protein( domain architecture ID 15333351)

tudor domain-containing protein adopts a beta-barrel-like structure and may bind to proteins with dimethylated arginine or lysine residues, or to methylated histone tails to facilitate protein-protein interactions; similar to Homo sapiens RING finger protein 17 involved in regulation of transcriptional activity of MYC

CATH:  2.30.30.140
Gene Ontology:  GO:0005515
PubMed:  24035451|22669818|20728048
SCOP:  4003195

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tudor_TDRD4_rpt5 cd20418
fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 1115-1219 9.46e-66

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


:

Pssm-ID: 410489  Cd Length: 105  Bit Score: 216.89  E-value: 9.46e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912 1115 LTDFRTEMPCLAEYDDGLWYRAKIVAIKEFNPLSILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAGFKPPLR 1194
Cdd:cd20418     1 LTDFRPEMPCLAEYSDGKWYRAKLLSILEFNPVKILVRHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFKPPLN 80

                          90       100
                  ....*....|....*....|....*
gi 767977912 1195 DLGETRIPYCPKWSMEALWAMIDCL 1219
Cdd:cd20418    81 DSETERIPYCPEWSMKALWAMIDLL 105
Tudor_TDRD4_rpt2 cd20415
second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 292-436 3.37e-45

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


:

Pssm-ID: 410486  Cd Length: 96  Bit Score: 157.98  E-value: 3.37e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  292 ILFLLKTIEEFYKSEDGENLEILCPVQDQACVAKFEDGIWYRAKVIelnhwescwkscidrtkqqkliiqkpvnsslmlt 371
Cdd:cd20415     1 FLILTKKIQEFYKEGDDGGLEILCPVQGQACVALFEDGAWYRARII---------------------------------- 46

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767977912  372 vclshailivkvqikGLPGHQEVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEKAIKCKLAYIEP 436
Cdd:cd20415    47 ---------------GLPGHREVEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKARECRLAFIEP 96
Tudor_TDRD4_rpt3 cd20416
third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 583-664 4.03e-43

third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


:

Pssm-ID: 410487  Cd Length: 82  Bit Score: 151.49  E-value: 4.03e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  583 LEEKMIAAYENSKWEPVKWENDMHCAVKIQDKNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNVDCLRKLEENLKTMGRL 662
Cdd:cd20416     1 LQEKMIAEYENSKPEPVKWENDMHCAVQIQDKKQWRRGQIIRVVSDTLVEVFLYDFGNKEVVNIDCLRKLEENLKTIGKL 80


                  ..
gi 767977912  663 SL 664
Cdd:cd20416    81 AL 82
Tudor_TDRD4_rpt4 cd20417
fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 867-934 8.95e-42

fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


:

Pssm-ID: 410488  Cd Length: 68  Bit Score: 147.20  E-value: 8.95e-42
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767977912  867 WKKGEACAVRGSDTLWYRGKVMEVVGGAVRVQYLDHGFTEKIPQCHLYPILLYPDIPQFCIPCQLHNT 934
Cdd:cd20417     1 WKKGEGCVVRGSDTLWYRGKVLEVIGGMVRVQYVDQGYIEKIPQCHLYPMVLYPDIPQFCIPCQLYGT 68
Tudor_TDRD4_rpt1 cd20414
first Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 54-130 4.41e-38

first Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


:

Pssm-ID: 410485  Cd Length: 77  Bit Score: 136.95  E-value: 4.41e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767977912   54 ELGARIFVSSIKNGMWCRGTITELIPIEGRNTRKPCSPTRLFVHEVALIQIFMVDFGNSEVLIVTGVVDTHVRPEHS 130
Cdd:cd20414     1 ELGERIAVKSKKNGMWCRGTITELIPLENKNKGKPCGPTRYKIHDVAVMQVFLLDYGHSEVFVVTGVGVLVVRPEDV 77
 
Name Accession Description Interval E-value
Tudor_TDRD4_rpt5 cd20418
fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 1115-1219 9.46e-66

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410489  Cd Length: 105  Bit Score: 216.89  E-value: 9.46e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912 1115 LTDFRTEMPCLAEYDDGLWYRAKIVAIKEFNPLSILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAGFKPPLR 1194
Cdd:cd20418     1 LTDFRPEMPCLAEYSDGKWYRAKLLSILEFNPVKILVRHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFKPPLN 80

                          90       100
                  ....*....|....*....|....*
gi 767977912 1195 DLGETRIPYCPKWSMEALWAMIDCL 1219
Cdd:cd20418    81 DSETERIPYCPEWSMKALWAMIDLL 105
Tudor_TDRD4_rpt2 cd20415
second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 292-436 3.37e-45

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410486  Cd Length: 96  Bit Score: 157.98  E-value: 3.37e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  292 ILFLLKTIEEFYKSEDGENLEILCPVQDQACVAKFEDGIWYRAKVIelnhwescwkscidrtkqqkliiqkpvnsslmlt 371
Cdd:cd20415     1 FLILTKKIQEFYKEGDDGGLEILCPVQGQACVALFEDGAWYRARII---------------------------------- 46

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767977912  372 vclshailivkvqikGLPGHQEVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEKAIKCKLAYIEP 436
Cdd:cd20415    47 ---------------GLPGHREVEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKARECRLAFIEP 96
Tudor_TDRD4_rpt3 cd20416
third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 583-664 4.03e-43

third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410487  Cd Length: 82  Bit Score: 151.49  E-value: 4.03e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  583 LEEKMIAAYENSKWEPVKWENDMHCAVKIQDKNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNVDCLRKLEENLKTMGRL 662
Cdd:cd20416     1 LQEKMIAEYENSKPEPVKWENDMHCAVQIQDKKQWRRGQIIRVVSDTLVEVFLYDFGNKEVVNIDCLRKLEENLKTIGKL 80


                  ..
gi 767977912  663 SL 664
Cdd:cd20416    81 AL 82
Tudor_TDRD4_rpt4 cd20417
fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 867-934 8.95e-42

fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410488  Cd Length: 68  Bit Score: 147.20  E-value: 8.95e-42
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767977912  867 WKKGEACAVRGSDTLWYRGKVMEVVGGAVRVQYLDHGFTEKIPQCHLYPILLYPDIPQFCIPCQLHNT 934
Cdd:cd20417     1 WKKGEGCVVRGSDTLWYRGKVLEVIGGMVRVQYVDQGYIEKIPQCHLYPMVLYPDIPQFCIPCQLYGT 68
Tudor_TDRD4_rpt1 cd20414
first Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 54-130 4.41e-38

first Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410485  Cd Length: 77  Bit Score: 136.95  E-value: 4.41e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767977912   54 ELGARIFVSSIKNGMWCRGTITELIPIEGRNTRKPCSPTRLFVHEVALIQIFMVDFGNSEVLIVTGVVDTHVRPEHS 130
Cdd:cd20414     1 ELGERIAVKSKKNGMWCRGTITELIPLENKNKGKPCGPTRYKIHDVAVMQVFLLDYGHSEVFVVTGVGVLVVRPEDV 77
TUDOR pfam00567
Tudor domain;
819-933 2.33e-24

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 98.97  E-value: 2.33e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912   819 NVFEATVSCVGDDGTIFVVPKLSEFELIKMTNEIQSNLKCLGLLEPYFWKKGEACAVRGSDTLWYRGKVMEVV-GGAVRV 897
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLdDGLVEV 80

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 767977912   898 QYLDHGFTEKIPQCHLYPILLYPD-IPQFCIPCQLHN 933
Cdd:pfam00567   81 LFIDYGNTETVPLSDLRPLPPELEsLPPQAIKCQLAG 117
TUDOR pfam00567
Tudor domain;
268-432 1.47e-13

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 68.15  E-value: 1.47e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912   268 DVSVTVCHINSPGDFYLQLIEGLDILF-LLKTIEEFYKSeDGENLEILCPVQDQACVAKfEDGIWYRAKVIELnhwescw 346
Cdd:pfam00567    2 TIDVVVSHIESPSTFYIQPKSDSKKLEkLTEELQEYYAS-KPPESLPPAVGDGCVAAFS-EDGKWYRAKITES------- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912   347 kscidrtkqqkliiqkpvnsslmltvclshailivkvqikglPGHQEVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEKA 426
Cdd:pfam00567   73 ------------------------------------------LDDGLVEVLFIDYGNTETVPLSDLRPLPPELESLPPQA 110


                   ....*.
gi 767977912   427 IKCKLA 432
Cdd:pfam00567  111 IKCQLA 116
TUDOR pfam00567
Tudor domain;
1053-1188 1.50e-13

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 68.15  E-value: 1.50e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  1053 AVQVKHVVSPNEVYIcldsietsnQSnqhsdtddsgVSGESESESLDEALQRVNKKVEAlPPLTDFRTEMPCLAEYDDGL 1132
Cdd:pfam00567    4 DVVVSHIESPSTFYI---------QP----------KSDSKKLEKLTEELQEYYASKPP-ESLPPAVGDGCVAAFSEDGK 63

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767977912  1133 WYRAKIVAIKEfNPLsILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAG 1188
Cdd:pfam00567   64 WYRAKITESLD-DGL-VEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117
TUDOR pfam00567
Tudor domain;
558-668 3.98e-11

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 61.22  E-value: 3.98e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912   558 VHICNVISPEKIYVQWLLTENLLNSLEEKMIAAYENSKWEPVKWENDMHCAVKIQDKNQWRRGQIIRMVTDTLVEVLLYD 637
Cdd:pfam00567    5 VVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGLVEVLFID 84

                           90       100       110
                   ....*....|....*....|....*....|.
gi 767977912   638 VGVELVVNVDCLRKLEENLKTMGRLSLECSL 668
Cdd:pfam00567   85 YGNTETVPLSDLRPLPPELESLPPQAIKCQL 115
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
 1122-1174 3.68e-09

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 53.82  E-value: 3.68e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 767977912   1122 MPCLAEYDDGLWYRAKIVAIKEFNplSILVQFVDYGSTAKLTLNRLCQIPSHL 1174
Cdd:smart00333    7 DKVAARWEDGEWYRARIVKVDGEQ--LYEVFFIDYGNEEVVPPSDLRQLPEEL 57
TUDOR pfam00567
Tudor domain;
8-115 1.29e-08

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 54.28  E-value: 1.29e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912     8 VFVSHVIDPCHFYIRKYSQIKDAKVLEKKVNEFCNRSSHLDPSDILELGARIFVSSikNGMWCRGTITELIPIEgrntrk 87
Cdd:pfam00567    5 VVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSE--DGKWYRAKITESLDDG------ 76

                           90       100
                   ....*....|....*....|....*...
gi 767977912    88 pcsptrlfvhevaLIQIFMVDFGNSEVL 115
Cdd:pfam00567   77 -------------LVEVLFIDYGNTETV 91
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
 867-916 1.60e-08

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 51.89  E-value: 1.60e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 767977912    867 WKKGEACAVRGSDTLWYRGKVMEVVG-GAVRVQYLDHGFTEKIPQCHLYPI 916
Cdd:smart00333    3 FKVGDKVAARWEDGEWYRARIVKVDGeQLYEVFFIDYGNEEVVPPSDLRQL 53
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
 598-654 1.44e-05

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 43.80  E-value: 1.44e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 767977912    598 PVKWENDMhCAVKIQDkNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNVDCLRKLEE 654
Cdd:smart00333    1 PTFKVGDK-VAARWED-GEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLRQLPE 55
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
 320-419 3.01e-03

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 37.25  E-value: 3.01e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912    320 QACVAKFEDGIWYRAKVIElnhwescwkscIDRTkqqkliiqkpvnsslmltvclshailivkvqikglpghQEVEVKYV 399
Cdd:smart00333    7 DKVAARWEDGEWYRARIVK-----------VDGE--------------------------------------QLYEVFFI 37

                            90       100
                    ....*....|....*....|
gi 767977912    400 DFGNTAKITIKDVRKIKDEF 419
Cdd:smart00333   38 DYGNEEVVPPSDLRQLPEEL 57
 
Name Accession Description Interval E-value
Tudor_TDRD4_rpt5 cd20418
fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 1115-1219 9.46e-66

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410489  Cd Length: 105  Bit Score: 216.89  E-value: 9.46e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912 1115 LTDFRTEMPCLAEYDDGLWYRAKIVAIKEFNPLSILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAGFKPPLR 1194
Cdd:cd20418     1 LTDFRPEMPCLAEYSDGKWYRAKLLSILEFNPVKILVRHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFKPPLN 80

                          90       100
                  ....*....|....*....|....*
gi 767977912 1195 DLGETRIPYCPKWSMEALWAMIDCL 1219
Cdd:cd20418    81 DSETERIPYCPEWSMKALWAMIDLL 105
Tudor_TDRD4_rpt2 cd20415
second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 292-436 3.37e-45

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410486  Cd Length: 96  Bit Score: 157.98  E-value: 3.37e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  292 ILFLLKTIEEFYKSEDGENLEILCPVQDQACVAKFEDGIWYRAKVIelnhwescwkscidrtkqqkliiqkpvnsslmlt 371
Cdd:cd20415     1 FLILTKKIQEFYKEGDDGGLEILCPVQGQACVALFEDGAWYRARII---------------------------------- 46

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767977912  372 vclshailivkvqikGLPGHQEVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEKAIKCKLAYIEP 436
Cdd:cd20415    47 ---------------GLPGHREVEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKARECRLAFIEP 96
Tudor_TDRD4_rpt3 cd20416
third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 583-664 4.03e-43

third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410487  Cd Length: 82  Bit Score: 151.49  E-value: 4.03e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  583 LEEKMIAAYENSKWEPVKWENDMHCAVKIQDKNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNVDCLRKLEENLKTMGRL 662
Cdd:cd20416     1 LQEKMIAEYENSKPEPVKWENDMHCAVQIQDKKQWRRGQIIRVVSDTLVEVFLYDFGNKEVVNIDCLRKLEENLKTIGKL 80


                  ..
gi 767977912  663 SL 664
Cdd:cd20416    81 AL 82
Tudor_TDRD4_rpt4 cd20417
fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 867-934 8.95e-42

fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410488  Cd Length: 68  Bit Score: 147.20  E-value: 8.95e-42
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767977912  867 WKKGEACAVRGSDTLWYRGKVMEVVGGAVRVQYLDHGFTEKIPQCHLYPILLYPDIPQFCIPCQLHNT 934
Cdd:cd20417     1 WKKGEGCVVRGSDTLWYRGKVLEVIGGMVRVQYVDQGYIEKIPQCHLYPMVLYPDIPQFCIPCQLYGT 68
Tudor_TDRD4_rpt1 cd20414
first Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 54-130 4.41e-38

first Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410485  Cd Length: 77  Bit Score: 136.95  E-value: 4.41e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767977912   54 ELGARIFVSSIKNGMWCRGTITELIPIEGRNTRKPCSPTRLFVHEVALIQIFMVDFGNSEVLIVTGVVDTHVRPEHS 130
Cdd:cd20414     1 ELGERIAVKSKKNGMWCRGTITELIPLENKNKGKPCGPTRYKIHDVAVMQVFLLDYGHSEVFVVTGVGVLVVRPEDV 77
TUDOR pfam00567
Tudor domain;
819-933 2.33e-24

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 98.97  E-value: 2.33e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912   819 NVFEATVSCVGDDGTIFVVPKLSEFELIKMTNEIQSNLKCLGLLEPYFWKKGEACAVRGSDTLWYRGKVMEVV-GGAVRV 897
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLdDGLVEV 80

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 767977912   898 QYLDHGFTEKIPQCHLYPILLYPD-IPQFCIPCQLHN 933
Cdd:pfam00567   81 LFIDYGNTETVPLSDLRPLPPELEsLPPQAIKCQLAG 117
TUDOR pfam00567
Tudor domain;
268-432 1.47e-13

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 68.15  E-value: 1.47e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912   268 DVSVTVCHINSPGDFYLQLIEGLDILF-LLKTIEEFYKSeDGENLEILCPVQDQACVAKfEDGIWYRAKVIELnhwescw 346
Cdd:pfam00567    2 TIDVVVSHIESPSTFYIQPKSDSKKLEkLTEELQEYYAS-KPPESLPPAVGDGCVAAFS-EDGKWYRAKITES------- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912   347 kscidrtkqqkliiqkpvnsslmltvclshailivkvqikglPGHQEVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEKA 426
Cdd:pfam00567   73 ------------------------------------------LDDGLVEVLFIDYGNTETVPLSDLRPLPPELESLPPQA 110


                   ....*.
gi 767977912   427 IKCKLA 432
Cdd:pfam00567  111 IKCQLA 116
TUDOR pfam00567
Tudor domain;
1053-1188 1.50e-13

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 68.15  E-value: 1.50e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  1053 AVQVKHVVSPNEVYIcldsietsnQSnqhsdtddsgVSGESESESLDEALQRVNKKVEAlPPLTDFRTEMPCLAEYDDGL 1132
Cdd:pfam00567    4 DVVVSHIESPSTFYI---------QP----------KSDSKKLEKLTEELQEYYASKPP-ESLPPAVGDGCVAAFSEDGK 63

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767977912  1133 WYRAKIVAIKEfNPLsILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAG 1188
Cdd:pfam00567   64 WYRAKITESLD-DGL-VEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117
Tudor_TDRD12_rpt2 cd20435
second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; ...
 1124-1195 1.33e-11

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410506  Cd Length: 134  Bit Score: 63.42  E-value: 1.33e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767977912 1124 CLAEYDDGLWYRAKIVAIKEFN----PLSILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAGFKPPLRD 1195
Cdd:cd20435    56 CAVEDENNLYHRVKVLEITEKDdktkPREVLVKFIDEGRVETVVVSQLLELPEELKSLPPQAVEVFLCNVKPVDND 131
Tudor_TDRD15_rpt4 cd20439
fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 269-431 3.59e-11

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410510  Cd Length: 125  Bit Score: 61.74  E-value: 3.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  269 VSVTVCHINSPGDFYLQLI-EGLDILFLLKTIEEFYK--SEDGENLEIlcpvqdqACVAKF-EDGIWYRAKVielnhwes 344
Cdd:cd20439    12 VDVKCSYVNSPGDFWCQLQtKSSELKSLMKQIQSYYLihNDPYKHGQI-------ACVAKYsKDGKWYRAAV-------- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  345 cwkscidrtkqQKLIIQKpvnsslmltvclshailivkvqikglpghqEVEVKYVDFGNTAKITIKDVRKIKDEFLNAPE 424
Cdd:cd20439    77 -----------LKQVSAK------------------------------EVDVIFVDYGNQERVLISDLRAIKPQFLLLEG 115


                  ....*..
gi 767977912  425 KAIKCKL 431
Cdd:cd20439   116 QAFRCSL 122
TUDOR pfam00567
Tudor domain;
558-668 3.98e-11

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 61.22  E-value: 3.98e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912   558 VHICNVISPEKIYVQWLLTENLLNSLEEKMIAAYENSKWEPVKWENDMHCAVKIQDKNQWRRGQIIRMVTDTLVEVLLYD 637
Cdd:pfam00567    5 VVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGLVEVLFID 84

                           90       100       110
                   ....*....|....*....|....*....|.
gi 767977912   638 VGVELVVNVDCLRKLEENLKTMGRLSLECSL 668
Cdd:pfam00567   85 YGNTETVPLSDLRPLPPELESLPPQAIKCQL 115
Tudor_TDRD15_rpt5 cd20440
fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 271-431 1.22e-10

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410511  Cd Length: 127  Bit Score: 60.16  E-value: 1.22e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  271 VTVCHINSPGDFYLQLIEGLDIL-FLLKTIEEFYKSEDGEnleILCPVQDQACVAK-FEDGIWYRAKVIelnhwescwks 348
Cdd:cd20440    14 VYITHVYSPAKFYCQLDRNTEILeALMEKIAEISKLFNSQ---ILDNCKTRLCLAKyFEDGQWYRALAH----------- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  349 cidrtkqqkliiqkPVNSSlmltvclshailivkvqikglpghQEVEVKYVDFGNTAKITIKDVRKIKDEF---LNAPEK 425
Cdd:cd20440    80 --------------PVESS------------------------SHLSVYFVDYGNKQIVEKNEVLPIPDTAvdlLLTPMQ 121


                  ....*.
gi 767977912  426 AIKCKL 431
Cdd:cd20440   122 AIKCCL 127
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
 1122-1174 3.68e-09

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 53.82  E-value: 3.68e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 767977912   1122 MPCLAEYDDGLWYRAKIVAIKEFNplSILVQFVDYGSTAKLTLNRLCQIPSHL 1174
Cdd:smart00333    7 DKVAARWEDGEWYRARIVKVDGEQ--LYEVFFIDYGNEEVVPPSDLRQLPEEL 57
Tudor_TDRD4_rpt2 cd20415
second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 1124-1191 4.58e-09

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410486  Cd Length: 96  Bit Score: 54.75  E-value: 4.58e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767977912 1124 CLAEYDDGLWYRAKIVAIKEFNplSILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAGFKP 1191
Cdd:cd20415    31 CVALFEDGAWYRARIIGLPGHR--EVEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKARECRLAFIEP 96
Tudor_dTUD-like cd20379
Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar ...
 869-916 8.62e-09

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410450  Cd Length: 50  Bit Score: 52.52  E-value: 8.62e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767977912  869 KGEACAVRGSDT-LWYRGKVMEVV-GGAVRVQYLDHGFTEKIPQCHLYPI 916
Cdd:cd20379     1 VGDLCAAKYEEDgKWYRARVLEVLsNDKVEVFFVDYGNTETVPLSDLRPL 50
Tudor_TDRD1_rpt1 cd20408
first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 271-436 9.78e-09

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410479  Cd Length: 130  Bit Score: 55.07  E-value: 9.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  271 VTVCHINSPGDFYLQlIEGLDILFLLKTIE----EFYKSEDGENLEIlcPVQDQACVAKF-EDGIWYRAKVIELNhwesc 345
Cdd:cd20408     1 GTVTEFKNPGEFYIQ-IYTLEVLESLVKLTsqlkKTYASVNNHKEYI--PEVGEVCVAKYsEDQNWYRALVQTVD----- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  346 wkscIDRTKQQkliiqkpvnsslmltvclshailivkvqikglpghqeveVKYVDFGNTAKITIKDVRKIKDEFLNAPEK 425
Cdd:cd20408    73 ----VQQKKAG---------------------------------------VFYIDYGNEETVPLNRIQPLKKDIELFPPC 109

                         170
                  ....*....|.
gi 767977912  426 AIKCKLAYIEP 436
Cdd:cd20408   110 AIKCCLANVKP 120
TUDOR pfam00567
Tudor domain;
8-115 1.29e-08

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 54.28  E-value: 1.29e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912     8 VFVSHVIDPCHFYIRKYSQIKDAKVLEKKVNEFCNRSSHLDPSDILELGARIFVSSikNGMWCRGTITELIPIEgrntrk 87
Cdd:pfam00567    5 VVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSE--DGKWYRAKITESLDDG------ 76

                           90       100
                   ....*....|....*....|....*...
gi 767977912    88 pcsptrlfvhevaLIQIFMVDFGNSEVL 115
Cdd:pfam00567   77 -------------LVEVLFIDYGNTETV 91
Tudor_dTUD-like cd20379
Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar ...
 604-652 1.60e-08

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410450  Cd Length: 50  Bit Score: 51.75  E-value: 1.60e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 767977912  604 DMHCAVKIQDKNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNVDCLRKL 652
Cdd:cd20379     2 GDLCAAKYEEDGKWYRARVLEVLSNDKVEVFFVDYGNTETVPLSDLRPL 50
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
 867-916 1.60e-08

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 51.89  E-value: 1.60e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 767977912    867 WKKGEACAVRGSDTLWYRGKVMEVVG-GAVRVQYLDHGFTEKIPQCHLYPI 916
Cdd:smart00333    3 FKVGDKVAARWEDGEWYRARIVKVDGeQLYEVFFIDYGNEEVVPPSDLRQL 53
Tudor_dTUD-like cd20379
Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar ...
 1122-1170 1.65e-08

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410450  Cd Length: 50  Bit Score: 51.75  E-value: 1.65e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767977912 1122 MPCLAEY-DDGLWYRAKIVAIKEFNplSILVQFVDYGSTAKLTLNRLCQI 1170
Cdd:cd20379     3 DLCAAKYeEDGKWYRARVLEVLSND--KVEVFFVDYGNTETVPLSDLRPL 50
Tudor_TDRD15_rpt5 cd20440
fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 1047-1186 2.90e-08

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410511  Cd Length: 127  Bit Score: 53.61  E-value: 2.90e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912 1047 SPGELYAVQVKHVVSPNEVYICLDSietsnqsnqhsdtddsgvsgesESESLDEALQRVNKKVEALP-PLTDFRTEMPCL 1125
Cdd:cd20440     7 KVGSEEEVYITHVYSPAKFYCQLDR----------------------NTEILEALMEKIAEISKLFNsQILDNCKTRLCL 64

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767977912 1126 AEY-DDGLWYRAKIVAIKefNPLSILVQFVDYGSTAKLTLNRLCQIPSH---LMRYPARAIKVLL 1186
Cdd:cd20440    65 AKYfEDGQWYRALAHPVE--SSSHLSVYFVDYGNKQIVEKNEVLPIPDTavdLLLTPMQAIKCCL 127
Tudor_TDRD6_rpt4 cd20423
fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 1117-1192 3.46e-08

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410494  Cd Length: 80  Bit Score: 51.71  E-value: 3.46e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767977912 1117 DFRTEMPCLAEY-DDGLWYRAKIVAIKEfNPLSILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAGFKPP 1192
Cdd:cd20423     2 HSLPNPVCLAKYsEDGKWCRALIDNVYE-PVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQP 77
Tudor_TDRD6_rpt6 cd20425
sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 558-668 6.21e-08

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410496  Cd Length: 115  Bit Score: 52.07  E-value: 6.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  558 VHICNVISPEKIYVQWLLTENLLNSLEEKMIAAYENSkwEPVKWE----NDMHCAVKIQDkNQWRRGQIIRMVTDTLVEV 633
Cdd:cd20425     4 VYVSHVNSPSDFYVQLAQDEDELSMISEKLNASKAND--EEVECEslqlGDLICAEYPED-GLWYRAVVKEKIPNNLVSV 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 767977912  634 LLYDVGVELVVNVDCLRKLEENLKTMGRLSLECSL 668
Cdd:cd20425    81 QFIDYGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115
Tudor_AKAP1 cd20407
Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; ...
 1124-1191 9.34e-08

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410478  Cd Length: 76  Bit Score: 50.28  E-value: 9.34e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767977912 1124 CLAEYDDGlWYRAKIVAIKEfNPLSILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAGFKP 1191
Cdd:cd20407    11 CAAPVMNA-WYRAQVVGVFE-ETDEVEIKYLDYGGYERVPVDDLRQIRSDFMTLPFQATECYLANIEP 76
Tudor_TDRD15_rpt2 cd20437
second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 558-668 1.13e-07

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410508  Cd Length: 120  Bit Score: 51.65  E-value: 1.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  558 VHICNVISPEKIYVQWLLTENLLNSLEEKMIAAYE--NSKWEPVKWENDMHCAVKIQDkNQWRRGQIIRMVTDTLVEVLL 635
Cdd:cd20437     7 VKITAAVSPSKFYCQLLSWEPELSKLTTQMTLHYEsvSKELNPSCENFGLLCAAKGKD-GQWHRGFLQQLLPPSQVKVWF 85

                          90       100       110
                  ....*....|....*....|....*....|...
gi 767977912  636 YDVGVELVVNVDCLRKLEENLKTMGRLSLECSL 668
Cdd:cd20437    86 IDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSL 118
Tudor_TDRD1_rpt1 cd20408
first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 844-946 2.24e-07

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410479  Cd Length: 130  Bit Score: 51.22  E-value: 2.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  844 ELIKMTNEIQSNLKCLGLLEPYFWKKGEACAVRGS-DTLWYRGKVMEV--VGGAVRVQYLDHGFTEKIPQCHLYPilLYP 920
Cdd:cd20408    24 SLVKLTSQLKKTYASVNNHKEYIPEVGEVCVAKYSeDQNWYRALVQTVdvQQKKAGVFYIDYGNEETVPLNRIQP--LKK 101

                          90       100
                  ....*....|....*....|....*....
gi 767977912  921 DIPQFC---IPCQLHNTTPVGNVWQPDAI 946
Cdd:cd20408   102 DIELFPpcaIKCCLANVKPPSGSWSEECI 130
Tudor_TDRD6_rpt7 cd20426
seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 1123-1189 3.15e-07

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410497  Cd Length: 140  Bit Score: 50.96  E-value: 3.15e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767977912 1123 PCLAEY-DDGLWYRAKIVAIKEfNPLSilVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAGF 1189
Cdd:cd20426    52 PCIVKYsEDNHWYRALVTKIND-NLVS--VRFVDYGNEEDVVREQVRALPSELLKIPVQAFPCCLSGF 116
Tudor_TDRD11 cd20433
Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, ...
 1095-1175 3.53e-07

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410504 [Multi-domain]  Cd Length: 84  Bit Score: 49.22  E-value: 3.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912 1095 SESLDEALQRVNKKVEALPPLT--------DFrtempCLAEY-DDGLWYRAKIVAIKefNPLSILVQFVDYGSTAKLTLN 1165
Cdd:cd20433     2 GPQLEKLMEKLRFEIASNPPLPgsytprkgDL-----CAAKFvEDGEWYRAKVEKVE--GDKKVHVLYIDYGNREVLPST 74

                          90
                  ....*....|
gi 767977912 1166 RLCQIPSHLM 1175
Cdd:cd20433    75 RLAALPPAFS 84
Tudor_TDRD6_rpt6 cd20425
sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 269-431 3.56e-07

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410496  Cd Length: 115  Bit Score: 50.15  E-value: 3.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  269 VSVTVCHINSPGDFYLQLIEGLDilfLLKTIEEFYKSEDGENLEILCP---VQDQACVAKFEDGIWYRAKVIElnhwesc 345
Cdd:cd20425     2 TEVYVSHVNSPSDFYVQLAQDED---ELSMISEKLNASKANDEEVECEslqLGDLICAEYPEDGLWYRAVVKE------- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  346 wkscidrtkqqkliiQKPVNSslmltvclshailivkvqikglpghqeVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEK 425
Cdd:cd20425    72 ---------------KIPNNL---------------------------VSVQFIDYGNTSVVQPSKIHRLPKELLSIPAL 109


                  ....*.
gi 767977912  426 AIKCKL 431
Cdd:cd20425   110 SIHCFL 115
Tudor_AKAP1 cd20407
Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; ...
 393-436 4.74e-07

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410478  Cd Length: 76  Bit Score: 48.36  E-value: 4.74e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 767977912  393 EVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEKAIKCKLAYIEP 436
Cdd:cd20407    33 EVEIKYLDYGGYERVPVDDLRQIRSDFMTLPFQATECYLANIEP 76
Tudor_TDRD15_rpt3 cd20438
third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 873-951 5.14e-07

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410509  Cd Length: 141  Bit Score: 50.17  E-value: 5.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  873 CAVRGSDTLWYRGKVMEVVGGAVRVQYLDHGFTEKIPQCHLYPIL-LYPDIPQFCIPCQLHNTTPVGNVWQPDAIEVLQQ 951
Cdd:cd20438    62 CARYSKDRHYYRAVITEVLDLKVSVYFLDFGNTDTVPFYDVKTLLpEFSELPALAMCCSLAHVFPVEEVWTKNANDFFKK 141
Tudor_TDRD1_rpt2 cd20409
second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 1096-1175 6.58e-07

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410480  Cd Length: 82  Bit Score: 48.22  E-value: 6.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912 1096 ESLDEALQRVNKKVEALPPLTDFRTEM--PCLAEY-DDGLWYRAKIVAIKefNPLSILVQFVDYGSTAKLTLNRLCQIPS 1172
Cdd:cd20409     2 RQLAELQESLSAYCKVAPASSDFSPAVgeVCCAQFtEDNQWYRASVLAYS--SEDSVLVGYIDFGNSEEVALSRLRPIPP 79


                  ...
gi 767977912 1173 HLM 1175
Cdd:cd20409    80 SLL 82
Tudor_TDRD6_rpt6 cd20425
sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 1054-1182 6.69e-07

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410496  Cd Length: 115  Bit Score: 49.38  E-value: 6.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912 1054 VQVKHVVSPNEVYICLDSietsnqsnqhsdtDDSGVSgeSESESLDEALQRVNKKVEALPPLTDfrteMPClAEY-DDGL 1132
Cdd:cd20425     4 VYVSHVNSPSDFYVQLAQ-------------DEDELS--MISEKLNASKANDEEVECESLQLGD----LIC-AEYpEDGL 63

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 767977912 1133 WYRAkIVAIKEFNPLsILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAI 1182
Cdd:cd20425    64 WYRA-VVKEKIPNNL-VSVQFIDYGNTSVVQPSKIHRLPKELLSIPALSI 111
Tudor_TDRD9 cd20431
Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is ...
 1112-1178 7.66e-07

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410502  Cd Length: 101  Bit Score: 48.54  E-value: 7.66e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912 1112 LPPLTDFRTEMPCLAEYDDGL---WYRAKIVAIkefNPLSILVQFVDYGSTAKLTLNRLCQIPSHLMRYP 1178
Cdd:cd20431    35 VPLTTKPVPNLLCLAPFTDADmkkYYRAKILYV---SGSSAEVFFVDYGNTSQVPSSLLREIPETLLTLP 101
Tudor_TDRD1_rpt3 cd20410
third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 1123-1175 7.87e-07

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410481 [Multi-domain]  Cd Length: 59  Bit Score: 47.34  E-value: 7.87e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767977912 1123 PCLAEY-DDGLWYRAkivAIKE-FNPLSILVQFVDYGSTAKLTLNRLCQIPSHLM 1175
Cdd:cd20410     8 PCCAFFsGDGNWYRA---MVKEiLPGGAVKVHFVDYGNVEEVTLDKLRKITSTFL 59
Tudor_TDRD6_rpt3 cd20422
third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 271-444 9.71e-07

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410493  Cd Length: 135  Bit Score: 49.43  E-value: 9.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  271 VTVCHINSPGDFYLQLIE-GLDILFLLKTIEEFYKSEDGENLEILCPVQDQACVAKFEDGIWYRAkvielnhwescwksc 349
Cdd:cd20422     4 AQVEFVKDPSEFWIRLGEhAVPFSKLMRSMTAFYSQASKLDGVVLKPQPGQLCCAKWKEDRYYRA--------------- 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  350 idrtkqqkliiqkpvnsslmltvclshaiLIVKVQIKGlpghqeVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEKAIKC 429
Cdd:cd20422    69 -----------------------------IVTAVKGKM------VEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKC 113

                         170
                  ....*....|....*
gi 767977912  430 KLAYIEPYKRTmqWS 444
Cdd:cd20422   114 CLADICPLGER--WS 126
Tudor_TDRD6_rpt5 cd20424
fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 1124-1186 1.11e-06

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410495  Cd Length: 126  Bit Score: 49.04  E-value: 1.11e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767977912 1124 CLAEYDDGLWYRAKIVAIKEfnplSILVQFVDYGSTAKLTLNRLCQIPS---HLMRYPARAIKVLL 1186
Cdd:cd20424    65 CLAKYSDQHWYRGIIITNKN----STEVFFVDYGNTEKVEKEDMLPIPSdayELLLLPMQAIKCSL 126
Tudor_TDRD11 cd20433
Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, ...
 847-916 1.21e-06

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410504 [Multi-domain]  Cd Length: 84  Bit Score: 47.68  E-value: 1.21e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767977912  847 KMTNEIQSNLKCLGLLEPyfwKKGEACAVRGS-DTLWYRGKVMEVVGGA-VRVQYLDHGFTEKIPQCHLYPI 916
Cdd:cd20433    11 KLRFEIASNPPLPGSYTP---RKGDLCAAKFVeDGEWYRAKVEKVEGDKkVHVLYIDYGNREVLPSTRLAAL 79
Tudor_TDRD15_rpt1 cd20436
first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 560-699 4.47e-06

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410507  Cd Length: 147  Bit Score: 47.80  E-value: 4.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  560 ICNVISPEKIYVQWlltENLLNSLEEKMIAAYENSKWEPVK----WENDMHCAVKIQDKNQWRRGQIIRmVTDTLVEVLL 635
Cdd:cd20436     5 THRVCHPKEVLVKF---QGQYNSICELDYHILQNEIQNATKskssWGVGEFCLVEDTTSGEWYRGRVLE-KIDEKYEVFL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767977912  636 YDVGVELVVNVDCLRKLEENLKTMGRLSLECSLVDIRPAGGsdKWTATACDCLS----LYLTGAVATI 699
Cdd:cd20436    81 IDRGEVLNVHATNMASASGELFQLPPKAVCGIFANILPIGE--KWSSTAVNYFSsligSQVKGYIQAI 146
Tudor_TDRD1_rpt3 cd20410
third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 868-916 5.12e-06

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410481 [Multi-domain]  Cd Length: 59  Bit Score: 45.02  E-value: 5.12e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767977912  868 KKGEAC-AVRGSDTLWYRGKVMEVV-GGAVRVQYLDHGFTEKIPQCHLYPI 916
Cdd:cd20410     4 IVGEPCcAFFSGDGNWYRAMVKEILpGGAVKVHFVDYGNVEEVTLDKLRKI 54
Tudor_TDRD15_rpt2 cd20437
second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 267-432 6.88e-06

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410508  Cd Length: 120  Bit Score: 46.64  E-value: 6.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  267 TDVSVTVCHINSPGDFYLQLIE-GLDILFLLKTIEEFYKSEDGENLEIlCPVQDQACVAKFEDGIWYRAKVIELnhwesc 345
Cdd:cd20437     3 TTEKVKITAAVSPSKFYCQLLSwEPELSKLTTQMTLHYESVSKELNPS-CENFGLLCAAKGKDGQWHRGFLQQL------ 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  346 wkscidrtkqqkliiqkpvnsslmltvclshailivkvqikgLPGHQeVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEK 425
Cdd:cd20437    76 ------------------------------------------LPPSQ-VKVWFIDYGNSEAVSSHSVLKLPPDFFSLPLM 112


                  ....*..
gi 767977912  426 AIKCKLA 432
Cdd:cd20437   113 SFPCSLS 119
Tudor_TDRD4_rpt2 cd20415
second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 853-936 1.15e-05

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410486  Cd Length: 96  Bit Score: 45.12  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  853 QSNLKCLGLLEPYfwkKGEACAVRGSDTLWYRGKVMEVVGG-AVRVQYLDHGFTEKIPQCHLYPIllyPD----IPQFCI 927
Cdd:cd20415    14 EGDDGGLEILCPV---QGQACVALFEDGAWYRARIIGLPGHrEVEVKYVDFGNTATVTIKHVRKI---KDdflsLPEKAR 87


                  ....*....
gi 767977912  928 PCQLHNTTP 936
Cdd:cd20415    88 ECRLAFIEP 96
Tudor_ZGPAT cd20384
Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and ...
 1124-1162 1.21e-05

Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and similar proteins; ZGPAT, also called ZIP, G patch domain-containing protein 6 (GPATC6), GPATCH6, zinc finger CCCH domain-containing protein 9 (ZC3HDC9), ZC3H9, or zinc finger and G patch domain-containing protein, is a transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. It represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410455  Cd Length: 55  Bit Score: 43.75  E-value: 1.21e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767977912 1124 CLAEYDDGLWYRAKIVAIKEFNplSILVQFVDYGSTAKL 1162
Cdd:cd20384    11 CLAKYDDGLWYPATVTDIDEDG--KYTVKFDSYGEVAVV 47
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
 598-654 1.44e-05

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 43.80  E-value: 1.44e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 767977912    598 PVKWENDMhCAVKIQDkNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNVDCLRKLEE 654
Cdd:smart00333    1 PTFKVGDK-VAARWED-GEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLRQLPE 55
Tudor_TDRD1_rpt4 cd20411
fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 864-931 1.88e-05

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410482  Cd Length: 116  Bit Score: 45.13  E-value: 1.88e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  864 PYFWKKGEACAVR-GSDTLWYRGKVMEVVGGAVRVQYLDHGFTEKIPQCHLYPIL-LYPDIPQFCIPCQL 931
Cdd:cd20411    45 QFRPRIGDACCARfTGDKNWYRAVVLETSDSEVKVLYADYGNTETLPLSRILPITkSHLELPFQIIRCSL 114
Tudor_TDRD4_rpt5 cd20418
fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 322-436 2.53e-05

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410489  Cd Length: 105  Bit Score: 44.32  E-value: 2.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  322 CVAKFEDGIWYRAKVIELNHWEscwkscidrtkqqkliiqkPVnsslmltvclshailivkvqikglpghqEVEVKYVDF 401
Cdd:cd20418    10 CLAEYSDGKWYRAKLLSILEFN-------------------PV----------------------------KILVRHVDY 42

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 767977912  402 GNTAKITIKDVRKIKDEFLNAPEKAIKCKLAYIEP 436
Cdd:cd20418    43 GSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFKP 77
Tudor_TDRD6_rpt5 cd20424
fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 271-431 2.85e-05

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410495  Cd Length: 126  Bit Score: 44.80  E-value: 2.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  271 VTVCHINSPGDFYLQLIEGLDILFLLK-TIEEFykSEDGENLEilCPVQDQA-CVAKFEDGIWYRAKVIELNhwescwks 348
Cdd:cd20424    16 VYITYVNDPWTFYCQLARNAGVLDQLAsAISRL--SSEIRKLE--LSVNPGTlCLAKYSDQHWYRGIIITNK-------- 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  349 cidrtkqqkliiqkpvnsslmltvclshailivkvqikglpghQEVEVKYVDFGNTAKITIKDVRKIKD---EFLNAPEK 425
Cdd:cd20424    84 -------------------------------------------NSTEVFFVDYGNTEKVEKEDMLPIPSdayELLLLPMQ 120


                  ....*.
gi 767977912  426 AIKCKL 431
Cdd:cd20424   121 AIKCSL 126
Tudor_dTUD-like cd20379
Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar ...
 319-415 5.38e-05

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410450  Cd Length: 50  Bit Score: 41.73  E-value: 5.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  319 DQACVAKFE-DGIWYRAKVIELNHwescwkscidrtkqqkliiqkpvnsslmltvclshailivkvqikglpgHQEVEVK 397
Cdd:cd20379     2 GDLCAAKYEeDGKWYRARVLEVLS-------------------------------------------------NDKVEVF 32

                          90
                  ....*....|....*...
gi 767977912  398 YVDFGNTAKITIKDVRKI 415
Cdd:cd20379    33 FVDYGNTETVPLSDLRPL 50
Tudor_TDRD6_rpt3 cd20422
third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 602-687 6.88e-05

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410493  Cd Length: 135  Bit Score: 44.04  E-value: 6.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  602 ENDMHCAVKIQDKNQWRrgQIIRMVTDTLVEVLLYDVGVELVVNVDCLRKLEENLKTMGRLSLECSLVDIRPAGgsDKWT 681
Cdd:cd20422    51 QPGQLCCAKWKEDRYYR--AIVTAVKGKMVEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLG--ERWS 126


                  ....*.
gi 767977912  682 ATACDC 687
Cdd:cd20422   127 PEAISA 132
Tudor_TDRD1_rpt1 cd20408
first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 1095-1192 6.94e-05

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410479  Cd Length: 130  Bit Score: 43.90  E-value: 6.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912 1095 SESLDEALQRVNKKVEALPPLTDFrtempCLAEY-DDGLWYRAKIVAIKEFNPLSiLVQFVDYGSTAKLTLNRLCQIPSH 1173
Cdd:cd20408    29 TSQLKKTYASVNNHKEYIPEVGEV-----CVAKYsEDQNWYRALVQTVDVQQKKA-GVFYIDYGNEETVPLNRIQPLKKD 102

                          90
                  ....*....|....*....
gi 767977912 1174 LMRYPARAIKVLLAGFKPP 1192
Cdd:cd20408   103 IELFPPCAIKCCLANVKPP 121
Tudor_TDRD15_rpt6 cd20441
sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 278-432 8.41e-05

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410512  Cd Length: 108  Bit Score: 43.19  E-value: 8.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  278 SPGDFYLQLIEglDILFLLKTIEEF--YKSEDGENLEILCPVQDqACVAKF-EDGIWYRAKVielnhwescwkscidrtk 354
Cdd:cd20441     1 SPSRFFIQLSE--DEKVILQLAEELneTSEKSRENAAVKLKVGD-LVAAEYdEDLALYRAVI------------------ 59

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767977912  355 qqkliiqkpvnsslmLTVClshailivkvqikglpGHQEVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEKAIKCKLA 432
Cdd:cd20441    60 ---------------TAVL----------------PGKSFKVEFIDYGNTAVVDKSNIYTLQEKFLSLPRLSIPCSLS 106
Tudor_TDRD6_rpt6 cd20425
sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 873-931 9.47e-05

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410496  Cd Length: 115  Bit Score: 43.21  E-value: 9.47e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767977912  873 CAVRGSDTLWYRGKVME-VVGGAVRVQYLDHGFTEKIPQCHLY---PILLypDIPQFCIPCQL 931
Cdd:cd20425    55 CAEYPEDGLWYRAVVKEkIPNNLVSVQFIDYGNTSVVQPSKIHrlpKELL--SIPALSIHCFL 115
Tudor_TDRD15_rpt6 cd20441
sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 1093-1188 9.92e-05

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410512  Cd Length: 108  Bit Score: 42.81  E-value: 9.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912 1093 SESES----LDEALQRVNKKVEALPpLTDFRTEMPCLAEYD-DGLWYRAKIVAIKEFNplSILVQFVDYGSTAKLTLNRL 1167
Cdd:cd20441    10 SEDEKvilqLAEELNETSEKSRENA-AVKLKVGDLVAAEYDeDLALYRAVITAVLPGK--SFKVEFIDYGNTAVVDKSNI 86

                          90       100
                  ....*....|....*....|.
gi 767977912 1168 CQIPSHLMRYPARAIKVLLAG 1188
Cdd:cd20441    87 YTLQEKFLSLPRLSIPCSLSG 107
Tudor_TDRD6_rpt3 cd20422
third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 861-946 1.12e-04

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410493  Cd Length: 135  Bit Score: 43.27  E-value: 1.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  861 LLEPyfwKKGEACAVRGSDTLWYRGKVMEVVGGAVRVQYLDHGFTEKIPQCHLYPILL-YPDIPQFCIPCQLHNTTPVGN 939
Cdd:cd20422    47 VLKP---QPGQLCCAKWKEDRYYRAIVTAVKGKMVEVFLVDRGNTEMVDWYDVKKLLPqFRELPALALKCCLADICPLGE 123


                  ....*..
gi 767977912  940 VWQPDAI 946
Cdd:cd20422   124 RWSPEAI 130
Tudor_TDRD15_rpt2 cd20437
second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 841-931 1.14e-04

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410508  Cd Length: 120  Bit Score: 43.18  E-value: 1.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  841 SEFELIKMTNEI----QSNLKCLGLLEPYFwkkGEACAVRGSDTLWYRGKVMEV-VGGAVRVQYLDHGFTEKIPQCHLYP 915
Cdd:cd20437    25 WEPELSKLTTQMtlhyESVSKELNPSCENF---GLLCAAKGKDGQWHRGFLQQLlPPSQVKVWFIDYGNSEAVSSHSVLK 101

                          90
                  ....*....|....*....
gi 767977912  916 ilLYPD---IPQFCIPCQL 931
Cdd:cd20437   102 --LPPDffsLPLMSFPCSL 118
Tudor_TDRD15_rpt7 cd20442
seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 558-666 1.20e-04

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410513  Cd Length: 160  Bit Score: 43.87  E-value: 1.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  558 VHICNVISPEKIYVQWLLTENLLNSLEEKMIAAYENSKWEPVKW-ENDMHCAVKIQDKNQWRRGQIIRMVTDTL-VEVLL 635
Cdd:cd20442     6 GTLLSVSKNGTFYVRLLRNSEQLTDLESLIAKEAKKCKFVPVEDiKEGLECLAKSKKNLKWYRAVVEHLYPETEkMLVFF 85

                          90       100       110
                  ....*....|....*....|....*....|.
gi 767977912  636 YDVGVELVVNVDCLRKLEENLKTMGRLSLEC 666
Cdd:cd20442    86 VDHGITEVVSMGNIKQLSNDLLQIPRQAVLC 116
Tudor_TDRD6_rpt3 cd20422
third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 1052-1212 2.28e-04

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410493  Cd Length: 135  Bit Score: 42.50  E-value: 2.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912 1052 YAVQVKHVVSPNEVYIcldsiETSNQSNQHSDTDDSGVSGESESESLDEALQRvnkkvealPPLTDFrtempCLAEYDDG 1131
Cdd:cd20422     2 YDAQVEFVKDPSEFWI-----RLGEHAVPFSKLMRSMTAFYSQASKLDGVVLK--------PQPGQL-----CCAKWKED 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912 1132 LWYRAKIVAIKEfnpLSILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAgfkpplrDLGetriPYCPKWSMEA 1211
Cdd:cd20422    64 RYYRAIVTAVKG---KMVEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLA-------DIC----PLGERWSPEA 129


                  .
gi 767977912 1212 L 1212
Cdd:cd20422   130 I 130
Tudor_TDRD6_rpt2 cd20421
second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 868-932 2.67e-04

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410492  Cd Length: 130  Bit Score: 42.03  E-value: 2.67e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767977912  868 KKGEACAVRGSDTLWYRGKVMEVVGG--AVRVQYLDHGFTEKIPQCHLYPILL-YPDIPQFCIPCQLH 932
Cdd:cd20421    62 KLGSPCAARGSDGRWYRAVLQQVFSAnrVVEVLHVDYGRKEVVSVSNLRYLAPeYFRMPVVTYPCALF 129
Tudor_TDRD15_rpt5 cd20440
fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 2-127 3.22e-04

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410511  Cd Length: 127  Bit Score: 42.06  E-value: 3.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912    2 CSSAELVFVSHVIDPCHFYIRKYSQIKDAKVLEKKVNEFCN--RSSHLDPSDILELGARIFvssiKNGMWCRGTItelIP 79
Cdd:cd20440     8 VGSEEEVYITHVYSPAKFYCQLDRNTEILEALMEKIAEISKlfNSQILDNCKTRLCLAKYF----EDGQWYRALA---HP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 767977912   80 IEgrntrkpcSPTRLfvhevaliQIFMVDFGNSEVlivtgVVDTHVRP 127
Cdd:cd20440    81 VE--------SSSHL--------SVYFVDYGNKQI-----VEKNEVLP 107
Tudor_TDRD1_rpt1 cd20408
first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 565-685 3.36e-04

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410479  Cd Length: 130  Bit Score: 41.97  E-value: 3.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  565 SPEKIYVQWLLTENL--LNSLEEKMIAAYENS----KWEPVKWENdmhCAVKIQDKNQWRRGQII-RMVTDTLVEVLLYD 637
Cdd:cd20408     8 NPGEFYIQIYTLEVLesLVKLTSQLKKTYASVnnhkEYIPEVGEV---CVAKYSEDQNWYRALVQtVDVQQKKAGVFYID 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 767977912  638 VGVELVVNVDCLRKLEENLKTMGRLSLECSLVDIRPAGGSdkWTATAC 685
Cdd:cd20408    85 YGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGS--WSEECI 130
Tudor_SMN_SPF30-like cd21182
Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing ...
 1122-1170 5.04e-04

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410549  Cd Length: 50  Bit Score: 39.16  E-value: 5.04e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767977912 1122 MPCLAEY-DDGLWYRAKIVAIKEfNPLSILVQFVDYGSTAKLTLNRLCQI 1170
Cdd:cd21182     2 DKCLAPYsDDGKYYEATIEEITE-ESDTATVVFDGYGNSEEVPLSDLKPL 50
Tudor_TDRD6_rpt4 cd20423
fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 392-431 5.33e-04

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410494  Cd Length: 80  Bit Score: 40.16  E-value: 5.33e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 767977912  392 QEVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEKAIKCKL 431
Cdd:cd20423    32 EMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSL 71
Tudor_TDRD7_rpt1 cd20427
first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ...
 394-437 5.54e-04

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410498  Cd Length: 98  Bit Score: 40.49  E-value: 5.54e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 767977912  394 VEVKYVDFGNTAKITIKDVRKIKDEFLNAPEKAIKCKLAYIEPY 437
Cdd:cd20427    51 VKVYYVDHGFSEVVERSKLFKLNKQFYSLPFQATKCKLAGLEPF 94
Tudor_TDRD7_rpt2 cd20428
second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ...
 1124-1191 5.80e-04

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410499  Cd Length: 140  Bit Score: 41.28  E-value: 5.80e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767977912 1124 CLAEYDdGLWYRAKIVAIKEFNPLSilVQFVDYGSTAKLTLNRLCQIPSHLMR----YPARAIKVLLAGFKP 1191
Cdd:cd20428    58 CLARYK-GKWARVEITNVHSSRALD--VHFLDTGTVASVKVSELREIPPPFLRelisIPPQALKCCLADLPL 126
Tudor_TDRD1_rpt4 cd20411
fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 393-432 6.01e-04

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410482  Cd Length: 116  Bit Score: 40.89  E-value: 6.01e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 767977912  393 EVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEKAIKCKLA 432
Cdd:cd20411    76 EVKVLYADYGNTETLPLSRILPITKSHLELPFQIIRCSLA 115
Tudor_TDRD15_rpt1 cd20436
first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 842-956 6.35e-04

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410507  Cd Length: 147  Bit Score: 41.64  E-value: 6.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  842 EFELIKMTNEIQSNLKclgllEPYFWKKGEACAVRGSDT-LWYRGKVMEVVGGAVRVQYLDHGFTEKIPQCHLYPI---L 917
Cdd:cd20436    27 ELDYHILQNEIQNATK-----SKSSWGVGEFCLVEDTTSgEWYRGRVLEKIDEKYEVFLIDRGEVLNVHATNMASAsgeL 101

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 767977912  918 LypDIPQFCIPCQLHNTTPVGNVWQPDAIEVLQQLLSKR 956
Cdd:cd20436   102 F--QLPPKAVCGIFANILPIGEKWSSTAVNYFSSLIGSQ 138
Tudor_TDRD12_rpt2 cd20435
second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; ...
 868-914 7.71e-04

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410506  Cd Length: 134  Bit Score: 41.08  E-value: 7.71e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767977912  868 KKGEACAVRGSDTLWYRGKVMEVV-----GGA--VRVQYLDHGFTEKIPQCHLY 914
Cdd:cd20435    51 KVGDLCAVEDENNLYHRVKVLEITekddkTKPreVLVKFIDEGRVETVVVSQLL 104
Tudor_TDRD6_rpt7 cd20426
seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 276-432 8.27e-04

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410497  Cd Length: 140  Bit Score: 40.95  E-value: 8.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  276 INSPGDFYLQL-IEGLDilFLLKTIEEFYKSEDGENLEILCPVQDQACVAKF-EDGIWYRAKVielnhwescwkscidrt 353
Cdd:cd20426     8 VDSPEYFWCQFaTEKIQ--CLAVKVQEAGEQVADRGNFIPSIYVGDPCIVKYsEDNHWYRALV----------------- 68

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767977912  354 kqqkliiqKPVNSSLmltvclshailivkvqikglpghqeVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEKAIKCKLA 432
Cdd:cd20426    69 --------TKINDNL-------------------------VSVRFVDYGNEEDVVREQVRALPSELLKIPVQAFPCCLS 114
Tudor_TDRD6_rpt2 cd20421
second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 269-431 8.63e-04

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410492  Cd Length: 130  Bit Score: 40.87  E-value: 8.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  269 VSVTVCHINSPGDFYLQL-IEGLDILFLLKTIEEFYKSEDGENLEILCPVQDQACVAKFEDGIWYRAKVIELnhwescwk 347
Cdd:cd20421    13 ETVVVTEVTDPHRIFCQLrSLSQELKRLSESMHQYYEGRVGSGYETRPEKLGSPCAARGSDGRWYRAVLQQV-------- 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  348 scidrtkqqkliiqkpvnsslmltvclshailivkvqikgLPGHQEVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEKAI 427
Cdd:cd20421    85 ----------------------------------------FSANRVVEVLHVDYGRKEVVSVSNLRYLAPEYFRMPVVTY 124


                  ....
gi 767977912  428 KCKL 431
Cdd:cd20421   125 PCAL 128
Tudor_TDRD7_rpt1 cd20427
first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ...
 1096-1191 1.02e-03

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410498  Cd Length: 98  Bit Score: 39.72  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912 1096 ESLDEALQRVNKKVEALPPLTDFRTEMPCLAEYDDGLWYRAKIVAIKEfnpLSILVQFVDYGSTAKLTLNRLCQIPSHLM 1175
Cdd:cd20427     1 EQMEDEMKEFYSKSSTAMCLRSPSVGQLVAVKAEEDAWLRAQVIEVEE---DKVKVYYVDHGFSEVVERSKLFKLNKQFY 77

                          90
                  ....*....|....*.
gi 767977912 1176 RYPARAIKVLLAGFKP 1191
Cdd:cd20427    78 SLPFQATKCKLAGLEP 93
Tudor_AtTudor1-like cd20443
Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor ...
 280-436 1.09e-03

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410514 [Multi-domain]  Cd Length: 117  Bit Score: 40.14  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  280 GDFYLQLIEGLDILFLLKTIEEfYKSEDGENLE-ILCPVQDQACVAKFE-DGIWYRAKVIElnhwescwkscidRTKQqk 357
Cdd:cd20443     2 GRFYVQVVSDQRLSSIQQQLEG-LSLKDKANPPgGFNPKKGELVLAQFSaDNSWNRAMVVN-------------APRQ-- 65

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767977912  358 liiqkPVNSslmltvclshailivkvqikglpGHQEVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEKAIKCKLAYIEP 436
Cdd:cd20443    66 -----GTQS-----------------------PKDEYEVFYIDYGNQETVPLSALRPLDPSVSSAPGLAQLCSLAHIKV 116
Tudor_TDRD7_rpt3 cd20429
third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ...
 580-654 1.44e-03

third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410500  Cd Length: 91  Bit Score: 39.01  E-value: 1.44e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767977912  580 LNSLEEKMIAAYENSKWEPVKWENDMHCAVKIQdkNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNVDCLRKLEE 654
Cdd:cd20429     9 LEVLMEEMILYYNKTEERPVAIEKNKVYAAKIE--NNWYRVLVKGILTNGLVSVYELDYGKHELVSIRKVQPLIE 81
Tudor_TDRD7_rpt1 cd20427
first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ...
 847-926 2.46e-03

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410498  Cd Length: 98  Bit Score: 38.56  E-value: 2.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  847 KMTNEIQSNLKCLGLLEPyfwKKGEACAVRGSDTLWYRGKVMEVVGGAVRVQYLDHGFTEKIPQCHLYPILlypdiPQFC 926
Cdd:cd20427     6 EMKEFYSKSSTAMCLRSP---SVGQLVAVKAEEDAWLRAQVIEVEEDKVKVYYVDHGFSEVVERSKLFKLN-----KQFY 77
Tudor_vreteno-like_rpt1 cd20444
first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; ...
 1122-1174 2.72e-03

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410515  Cd Length: 55  Bit Score: 37.28  E-value: 2.72e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767977912 1122 MPCLAEYDdGLWYRAKIVAIKEFNPlSILVQFVDYGSTAKLTLNRLCQIPSHL 1174
Cdd:cd20444     5 QMVIAKFD-GNHYRAIVLRVLNPDL-KILVRFVDFGNVEVMKLENLYECPEYL 55
Tudor_TDRD15_rpt3 cd20438
third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 393-436 2.85e-03

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410509  Cd Length: 141  Bit Score: 39.38  E-value: 2.85e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 767977912  393 EVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEKAIKCKLAYIEP 436
Cdd:cd20438    83 KVSVYFLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSLAHVFP 126
Tudor_TDRD15_rpt4 cd20439
fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 1124-1189 2.99e-03

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410510  Cd Length: 125  Bit Score: 39.01  E-value: 2.99e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767977912 1124 CLAEY-DDGLWYRAKIVaiKEFNPLSILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAGF 1189
Cdd:cd20439    61 CVAKYsKDGKWYRAAVL--KQVSAKEVDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
 320-419 3.01e-03

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 37.25  E-value: 3.01e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912    320 QACVAKFEDGIWYRAKVIElnhwescwkscIDRTkqqkliiqkpvnsslmltvclshailivkvqikglpghQEVEVKYV 399
Cdd:smart00333    7 DKVAARWEDGEWYRARIVK-----------VDGE--------------------------------------QLYEVFFI 37

                            90       100
                    ....*....|....*....|
gi 767977912    400 DFGNTAKITIKDVRKIKDEF 419
Cdd:smart00333   38 DYGNEEVVPPSDLRQLPEEL 57
Tudor_TDRD2 cd20412
Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, ...
 1129-1182 4.75e-03

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410483  Cd Length: 95  Bit Score: 37.66  E-value: 4.75e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767977912 1129 DDGLWYRAKIVAIKEfnPLSILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAI 1182
Cdd:cd20412    41 HDGSWYRARVLGFLE--NGNLDLYFVDYGDSGYVPLEDLRALRSDFLSLPFQAI 92
Tudor_TDRD1_rpt4 cd20411
fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 1124-1188 4.80e-03

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410482  Cd Length: 116  Bit Score: 38.20  E-value: 4.80e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767977912 1124 CLAEYD-DGLWYRAKIVAIKEfnpLSILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAG 1188
Cdd:cd20411    54 CCARFTgDKNWYRAVVLETSD---SEVKVLYADYGNTETLPLSRILPITKSHLELPFQIIRCSLAG 116
Tudor_TDRD5 cd20419
Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is ...
 382-431 4.85e-03

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410490  Cd Length: 118  Bit Score: 38.20  E-value: 4.85e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767977912  382 KVQIKGLPGHQEVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEKAIKCKL 431
Cdd:cd20419    69 RVIIHQVLNKQEVEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118
Tudor_TDRD5 cd20419
Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is ...
 559-668 8.90e-03

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410490  Cd Length: 118  Bit Score: 37.43  E-value: 8.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977912  559 HICNVISPEKIYVQwLLTENLLNSLEEKMIA-----AYENSKWEPVKWENDMH----CAVKIQDKNQWRRGQIIRMVTDT 629
Cdd:cd20419     1 FVEYIESPSQFYVR-FYSKDTSEMLEDMMIEmrrcySNEHVSERYVMPEAFIQpgqvCCVRIPEDVWWYRVIIHQVLNKQ 79

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 767977912  630 LVEVLLYDVGVELVVNVDCLRKLEENLKTMGRLSLECSL 668
Cdd:cd20419    80 EVEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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