NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767942186|ref|XP_011533860|]
View 

adenylate kinase 9 isoform X13 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 269-437 3.97e-23

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


:

Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 98.08  E-value: 3.97e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  269 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEKLLLKTEkkvgpefeedseneqaakqeleelaiqanvkveeent 348
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTE------------------------------------- 43

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  349 kkqlpevqLTEEeevIKSSLMENEPLPPEILEVILSEWwLKEPIRSTGFILDGFPRYPEEAQFL---GDRGFFPDAAVFI 425
Cdd:cd01428    44 --------LGKK---AKEYIDSGKLVPDEIVIKLLKER-LKKPDCKKGFILDGFPRTVDQAEALdelLDEGIKPDKVIEL 111

                         170
                  ....*....|..
gi 767942186  426 QVDDQDIFDRLL 437
Cdd:cd01428   112 DVPDEVLIERIL 123
NK super family cl17190
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 689-816 4.78e-20

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


The actual alignment was detected with superfamily member cd01428:

Pssm-ID: 450170 [Multi-domain]  Cd Length: 194  Bit Score: 89.22  E-value: 4.78e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  689 RIIIVGPPKSGKTTVlcfsvAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLME 768
Cdd:cd01428     1 RILLLGPPGSGKGTQ-----AERLAKKYGLPHISTGDLLREEIAS--GTELGKKAKEYIDSGKLVPDEIVIKLLKERLKK 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767942186  769 SVCNTaGVVIDGYPVTKHQMNLLE---ARSIIPMVIFELSVPSKEIFKRLL 816
Cdd:cd01428    74 PDCKK-GFILDGFPRTVDQAEALDellDEGIKPDKVIELDVPDEVLIERIL 123
YHS COG3350
Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport ...
 206-261 4.92e-08

Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport and metabolism];


:

Pssm-ID: 442578  Cd Length: 56  Bit Score: 50.47  E-value: 4.92e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767942186  206 GDTKHFCPVVLKEnfiLQPGNTEEAAKYREKIYYFSSAEAKEKFLEHPEDYVAHEE 261
Cdd:COG3350     3 GVAMVIDPVCGMT---VDPGSAAYTAEYDGKTYYFCSEECRDKFKANPEKYLPQYG 55
YHS super family cl42732
Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport ...
 628-680 9.62e-03

Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport and metabolism];


The actual alignment was detected with superfamily member COG3350:

Pssm-ID: 478436  Cd Length: 56  Bit Score: 35.45  E-value: 9.62e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767942186  628 DPVklsEGETIKPVENAenpiYPVIHRQYIYFLSSKETKEKFMKNPIKYIRQP 680
Cdd:COG3350     9 DPV---CGMTVDPGSAA----YTAEYDGKTYYFCSEECRDKFKANPEKYLPQY 54
 
Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 269-437 3.97e-23

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 98.08  E-value: 3.97e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  269 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEKLLLKTEkkvgpefeedseneqaakqeleelaiqanvkveeent 348
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTE------------------------------------- 43

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  349 kkqlpevqLTEEeevIKSSLMENEPLPPEILEVILSEWwLKEPIRSTGFILDGFPRYPEEAQFL---GDRGFFPDAAVFI 425
Cdd:cd01428    44 --------LGKK---AKEYIDSGKLVPDEIVIKLLKER-LKKPDCKKGFILDGFPRTVDQAEALdelLDEGIKPDKVIEL 111

                         170
                  ....*....|..
gi 767942186  426 QVDDQDIFDRLL 437
Cdd:cd01428   112 DVPDEVLIERIL 123
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 689-816 4.78e-20

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 89.22  E-value: 4.78e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  689 RIIIVGPPKSGKTTVlcfsvAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLME 768
Cdd:cd01428     1 RILLLGPPGSGKGTQ-----AERLAKKYGLPHISTGDLLREEIAS--GTELGKKAKEYIDSGKLVPDEIVIKLLKERLKK 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767942186  769 SVCNTaGVVIDGYPVTKHQMNLLE---ARSIIPMVIFELSVPSKEIFKRLL 816
Cdd:cd01428    74 PDCKK-GFILDGFPRTVDQAEALDellDEGIKPDKVIELDVPDEVLIERIL 123
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 689-816 8.37e-17

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 80.36  E-value: 8.37e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186   689 RIIIVGPPKSGKTTVlcfsvAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLME 768
Cdd:TIGR01351    1 RLVLLGPPGSGKGTQ-----AKRIAEKYGLPHISTGDLLRAEIKA--GTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQ 73

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 767942186   769 SVCNTAGVVIDGYPVTKHQMNLLEARSIIPM-VIFELSVPSKEIFKRLL 816
Cdd:TIGR01351   74 NDDNENGFILDGFPRTLSQAEALDALLEEPIdAVIELDVPDEELVERLS 122
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 689-816 1.09e-14

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 74.39  E-value: 1.09e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  689 RIIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLME 768
Cdd:COG0563     2 RIILLGPPGAGKGT-----QAKRLAEKYGIPHISTGDMLRAAVKA--GTELGKKAKEYMDAGELVPDEIVIGLVKERLAQ 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767942186  769 SVCnTAGVVIDGYPVTKHQM----NLLEARSIIPMVIFELSVPSKEIFKRLL 816
Cdd:COG0563    75 PDC-ANGFILDGFPRTVAQAealdELLAELGIKLDAVIELDVDDEELVERLS 125
AAA_17 pfam13207
AAA domain;
693-820 9.84e-14

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 69.19  E-value: 9.84e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186   693 VGPPKSGKTTVlcfsvAKKITSEYGLKHLSIGGALRYVLNnhpETELALMLNwHLHKGMTAPDELAIQALELSLMESvCN 772
Cdd:pfam13207    1 TGVPGSGKTTQ-----LKKLAEKLGFPHISAGDLLREEAK---ERGLVEDRD-EMRKLPLEPQKELQKLAAERIAEE-AG 70

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767942186   773 TAGVVIDGYPVTKHQMNLLEA------RSIIPMVIFELSVPSKEIFKRLLLEKE 820
Cdd:pfam13207   71 EGGVIVDGHPRIKTPAGYLPGlpvevlRELKPDAIILLEADPEEILERRLKDRT 124
adk PRK00279
adenylate kinase; Reviewed
 689-816 1.33e-13

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 71.33  E-value: 1.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  689 RIIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLME 768
Cdd:PRK00279    2 RLILLGPPGAGKGT-----QAKFIAEKYGIPHISTGDMLRAAVKA--GTELGKEAKSYMDAGELVPDEIVIGLVKERLAQ 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767942186  769 SVCNTaGVVIDGYPVTKHQM----NLLEARSI-IPMVIfELSVPSKEIFKRLL 816
Cdd:PRK00279   75 PDCKN-GFLLDGFPRTIPQAealdEMLKELGIkLDAVI-EIDVPDEELVERLS 125
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 269-437 1.86e-12

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 67.85  E-value: 1.86e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  269 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQeklllktekkvgpefeedseneqAAKQELEELAIQAnvkveeent 348
Cdd:COG0563     2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLR-----------------------AAVKAGTELGKKA--------- 49

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  349 kkqlpevqlteeEEVIKSSLMenepLPPEILEVILsEWWLKEPIRSTGFILDGFPRYPEEAQFL----GDRGFFPDAAVF 424
Cdd:COG0563    50 ------------KEYMDAGEL----VPDEIVIGLV-KERLAQPDCANGFILDGFPRTVAQAEALdellAELGIKLDAVIE 112

                         170
                  ....*....|...
gi 767942186  425 IQVDDQDIFDRLL 437
Cdd:COG0563   113 LDVDDEELVERLS 125
YHS COG3350
Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport ...
 206-261 4.92e-08

Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport and metabolism];


Pssm-ID: 442578  Cd Length: 56  Bit Score: 50.47  E-value: 4.92e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767942186  206 GDTKHFCPVVLKEnfiLQPGNTEEAAKYREKIYYFSSAEAKEKFLEHPEDYVAHEE 261
Cdd:COG3350     3 GVAMVIDPVCGMT---VDPGSAAYTAEYDGKTYYFCSEECRDKFKANPEKYLPQYG 55
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 269-437 6.00e-08

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 54.55  E-value: 6.00e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186   269 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEklllktekkvgpEFEEDSENEQAAKQELEelaiqanvkveeent 348
Cdd:TIGR01351    1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRA------------EIKAGTPLGKKAKEYME--------------- 53

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186   349 KKQLpevqlteeeeviksslmenepLPPEILEVILSEWWLKEPIRSTGFILDGFPRYPEEAQFLGDRGFFP-DAAVFIQV 427
Cdd:TIGR01351   54 KGEL---------------------VPDEIVNQLVKERLTQNDDNENGFILDGFPRTLSQAEALDALLEEPiDAVIELDV 112

                          170
                   ....*....|
gi 767942186   428 DDQDIFDRLL 437
Cdd:TIGR01351  113 PDEELVERLS 122
adk PRK02496
adenylate kinase; Provisional
 269-437 3.61e-07

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 51.67  E-value: 3.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  269 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQeklllktekkvgpefeedseneqAAKQELEELAIQANvkveeent 348
Cdd:PRK02496    3 RLIFLGPPGAGKGTQAVVLAEHLHIPHISTGDILR-----------------------QAIKEQTPLGIKAQ-------- 51

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  349 kkqlpevqlteeeeviksSLMENEPLPPEILEVILSEWWLKEPIRSTGFILDGFPRYPEEAQFL-------GDRGffpDA 421
Cdd:PRK02496   52 ------------------GYMDKGELVPDQLVLDLVQERLQQPDAANGWILDGFPRKVTQAAFLdellqeiGQSG---ER 110

                         170
                  ....*....|....*.
gi 767942186  422 AVFIQVDDQDIFDRLL 437
Cdd:PRK02496  111 VVNLDVPDDVVVERLL 126
AAA_17 pfam13207
AAA domain;
273-437 4.31e-07

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 50.32  E-value: 4.31e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186   273 VGPQGSGK-TMCgRQLAEKLNIFHIQFEEVLqeklllktekkvgpeFEEdseneqAAKQELEElaiqanvkveeenTKKQ 351
Cdd:pfam13207    1 TGVPGSGKtTQL-KKLAEKLGFPHISAGDLL---------------REE------AKERGLVE-------------DRDE 45

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186   352 LPEVQLTEEEEVIKsslmeneplppEILEVIlsewwlKEPIRSTGFILDGFPRYPEEAQFLGD------RGFFPDAAVFI 425
Cdd:pfam13207   46 MRKLPLEPQKELQK-----------LAAERI------AEEAGEGGVIVDGHPRIKTPAGYLPGlpvevlRELKPDAIILL 108

                          170
                   ....*....|..
gi 767942186   426 QVDDQDIFDRLL 437
Cdd:pfam13207  109 EADPEEILERRL 120
FAP206 pfam12018
Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There ...
 211-259 4.55e-03

Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There are two conserved sequence motifs: GFC and GLL. This family is also known as UPF0704. This domain is found in FAP206, a protein associated with cilia and flagella. In the ciliate Tetrahymena, the cilium has radial spokes, each of which is a macromolecular complex essential for motility. A triplet of three radial spokes, RS1, RS2, and RS3, is repeated every 96 nm along the doublet microtubule. Each spoke has a distinct base that docks to the doublet and is linked to different inner dynein arms. Knockout of the FAP206 gene results in slow cell motility and the 96-nm repeats lack RS2 and dynein c. FAP206 is probably part of the front prong and docks RS2 and dynein c to the microtubule.


Pssm-ID: 463432  Cd Length: 273  Bit Score: 40.33  E-value: 4.55e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767942186   211 FCPVVL-KENFILQPGNTE-EAAKYREKIYYFSSAEAKEKFLEHPEDYVAH 259
Cdd:pfam12018  201 FCAWTLvVRDGLLLPGNPSiGVLKYKDKYYAFSSKEAAYEFASDPDRFIAA 251
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 266-343 5.52e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 38.89  E-value: 5.52e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186    266 PPLRICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEV----LQEKLLLKTEKKVGPEFEEDSENEQAAKQeLEELAIQANV 341
Cdd:smart00382    1 PGEVILIVGPPGSGKTTLARALARELGPPGGGVIYIdgedILEEVLDQLLLIIVGGKKASGSGELRLRL-ALALARKLKP 79


                    ..
gi 767942186    342 KV 343
Cdd:smart00382   80 DV 81
YHS COG3350
Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport ...
 628-680 9.62e-03

Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport and metabolism];


Pssm-ID: 442578  Cd Length: 56  Bit Score: 35.45  E-value: 9.62e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767942186  628 DPVklsEGETIKPVENAenpiYPVIHRQYIYFLSSKETKEKFMKNPIKYIRQP 680
Cdd:COG3350     9 DPV---CGMTVDPGSAA----YTAEYDGKTYYFCSEECRDKFKANPEKYLPQY 54
 
Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 269-437 3.97e-23

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 98.08  E-value: 3.97e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  269 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEKLLLKTEkkvgpefeedseneqaakqeleelaiqanvkveeent 348
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTE------------------------------------- 43

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  349 kkqlpevqLTEEeevIKSSLMENEPLPPEILEVILSEWwLKEPIRSTGFILDGFPRYPEEAQFL---GDRGFFPDAAVFI 425
Cdd:cd01428    44 --------LGKK---AKEYIDSGKLVPDEIVIKLLKER-LKKPDCKKGFILDGFPRTVDQAEALdelLDEGIKPDKVIEL 111

                         170
                  ....*....|..
gi 767942186  426 QVDDQDIFDRLL 437
Cdd:cd01428   112 DVPDEVLIERIL 123
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 689-816 4.78e-20

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 89.22  E-value: 4.78e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  689 RIIIVGPPKSGKTTVlcfsvAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLME 768
Cdd:cd01428     1 RILLLGPPGSGKGTQ-----AERLAKKYGLPHISTGDLLREEIAS--GTELGKKAKEYIDSGKLVPDEIVIKLLKERLKK 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767942186  769 SVCNTaGVVIDGYPVTKHQMNLLE---ARSIIPMVIFELSVPSKEIFKRLL 816
Cdd:cd01428    74 PDCKK-GFILDGFPRTVDQAEALDellDEGIKPDKVIELDVPDEVLIERIL 123
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 689-816 8.37e-17

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 80.36  E-value: 8.37e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186   689 RIIIVGPPKSGKTTVlcfsvAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLME 768
Cdd:TIGR01351    1 RLVLLGPPGSGKGTQ-----AKRIAEKYGLPHISTGDLLRAEIKA--GTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQ 73

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 767942186   769 SVCNTAGVVIDGYPVTKHQMNLLEARSIIPM-VIFELSVPSKEIFKRLL 816
Cdd:TIGR01351   74 NDDNENGFILDGFPRTLSQAEALDALLEEPIdAVIELDVPDEELVERLS 122
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 689-816 1.09e-14

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 74.39  E-value: 1.09e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  689 RIIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLME 768
Cdd:COG0563     2 RIILLGPPGAGKGT-----QAKRLAEKYGIPHISTGDMLRAAVKA--GTELGKKAKEYMDAGELVPDEIVIGLVKERLAQ 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767942186  769 SVCnTAGVVIDGYPVTKHQM----NLLEARSIIPMVIFELSVPSKEIFKRLL 816
Cdd:COG0563    75 PDC-ANGFILDGFPRTVAQAealdELLAELGIKLDAVIELDVDDEELVERLS 125
AAA_17 pfam13207
AAA domain;
693-820 9.84e-14

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 69.19  E-value: 9.84e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186   693 VGPPKSGKTTVlcfsvAKKITSEYGLKHLSIGGALRYVLNnhpETELALMLNwHLHKGMTAPDELAIQALELSLMESvCN 772
Cdd:pfam13207    1 TGVPGSGKTTQ-----LKKLAEKLGFPHISAGDLLREEAK---ERGLVEDRD-EMRKLPLEPQKELQKLAAERIAEE-AG 70

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767942186   773 TAGVVIDGYPVTKHQMNLLEA------RSIIPMVIFELSVPSKEIFKRLLLEKE 820
Cdd:pfam13207   71 EGGVIVDGHPRIKTPAGYLPGlpvevlRELKPDAIILLEADPEEILERRLKDRT 124
adk PRK00279
adenylate kinase; Reviewed
 689-816 1.33e-13

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 71.33  E-value: 1.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  689 RIIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLME 768
Cdd:PRK00279    2 RLILLGPPGAGKGT-----QAKFIAEKYGIPHISTGDMLRAAVKA--GTELGKEAKSYMDAGELVPDEIVIGLVKERLAQ 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767942186  769 SVCNTaGVVIDGYPVTKHQM----NLLEARSI-IPMVIfELSVPSKEIFKRLL 816
Cdd:PRK00279   75 PDCKN-GFLLDGFPRTIPQAealdEMLKELGIkLDAVI-EIDVPDEELVERLS 125
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 269-437 1.86e-12

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 67.85  E-value: 1.86e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  269 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQeklllktekkvgpefeedseneqAAKQELEELAIQAnvkveeent 348
Cdd:COG0563     2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLR-----------------------AAVKAGTELGKKA--------- 49

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  349 kkqlpevqlteeEEVIKSSLMenepLPPEILEVILsEWWLKEPIRSTGFILDGFPRYPEEAQFL----GDRGFFPDAAVF 424
Cdd:COG0563    50 ------------KEYMDAGEL----VPDEIVIGLV-KERLAQPDCANGFILDGFPRTVAQAEALdellAELGIKLDAVIE 112

                         170
                  ....*....|...
gi 767942186  425 IQVDDQDIFDRLL 437
Cdd:COG0563   113 LDVDDEELVERLS 125
ADK pfam00406
Adenylate kinase;
692-816 2.20e-10

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 61.17  E-value: 2.20e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186   692 IVGPPKSGKTTVlcfsvAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESVC 771
Cdd:pfam00406    1 LLGPPGAGKGTQ-----AEKIVQKYGLPHLSTGDLLRAEIKS--GTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDC 73

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 767942186   772 NTaGVVIDGYPVTKHQMNLLEA--RSIIPM-VIFELSVPSKEIFKRLL 816
Cdd:pfam00406   74 KN-GFLLDGFPRTVPQAEALEEllERGIKLdYVIEFDVPDEVLVERLT 120
PRK14528 PRK14528
adenylate kinase; Provisional
 689-824 4.55e-10

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 60.41  E-value: 4.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  689 RIIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLME 768
Cdd:PRK14528    3 NIIFMGPPGAGKGT-----QAKILCERLSIPQISTGDILREAVKN--QTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIRE 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767942186  769 SVCNTaGVVIDGYPVTKHQMNLLEA------RSIIPMVifELSVPSKEIFKRLLLEKENEQR 824
Cdd:PRK14528   76 ADCKN-GFLLDGFPRTVEQADALDAllknegKSIDKAI--NLEVPDGELLKRLLGRAEIEGR 134
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 686-816 1.11e-09

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 59.06  E-value: 1.11e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186   686 VPIrIIIVGPPKSGKTTvLCfsvaKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELS 765
Cdd:TIGR01360    3 CKI-IFIVGGPGSGKGT-QC----EKIVEKYGFTHLSTGDLLRAEVAS--GSERGKQLQAIMESGDLVPLDTVLDLLKDA 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767942186   766 LMESVCNTAGVVIDGYPVTKHQMNLLEARSIIPMVIFELSVPSKEIFKRLL 816
Cdd:TIGR01360   75 MVAALGTSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLL 125
PRK14527 PRK14527
adenylate kinase; Provisional
 685-882 1.45e-09

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 59.03  E-value: 1.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  685 TVPIRIIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGGALR-YVLNNhpeTELALMLNWHLHKGMTAPDELAIQAL- 762
Cdd:PRK14527    4 TKNKVVIFLGPPGAGKGT-----QAERLAQELGLKKLSTGDILRdHVARG---TELGQRAKPIMEAGDLVPDELILALIr 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  763 -ELSLMESVcntaGVVIDGYPVTKHQMN----LLEARSIIPMVIFELSVPSKEIFKRLLLEKENEQRLPyplHNSAQIVA 837
Cdd:PRK14527   76 dELAGMEPV----RVIFDGFPRTLAQAEaldrLLEELGARLLAVVLLEVPDEELIRRIVERARQEGRSD---DNEETVRR 148

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 767942186  838 VNNVkYRKNIGEIRQYYQEQHQnWYVIDGFHSKWWVWNEVIKNVQ 882
Cdd:PRK14527  149 RQQV-YREQTQPLVDYYEARGH-LKRVDGLGTPDEVYARILKALG 191
PRK14530 PRK14530
adenylate kinase; Provisional
 689-815 3.50e-08

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 55.18  E-value: 3.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  689 RIIIVGPPKSGKTTVlcfsvAKKITSEYGLKHLSIGGALR---YVLNNHPETEL----ALMlnwhlHKGMTAPDELAIQA 761
Cdd:PRK14530    5 RILLLGAPGAGKGTQ-----SSNLAEEFGVEHVTTGDALRankQMDISDMDTEYdtpgEYM-----DAGELVPDAVVNEI 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767942186  762 LElslmESVCNTAGVVIDGYPVTKHQMNLLEARSIIPMVIFeLSVPSKEIFKRL 815
Cdd:PRK14530   75 VE----EALSDADGFVLDGYPRNLEQAEYLESITDLDVVLY-LDVSEEELVDRL 123
YHS COG3350
Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport ...
 206-261 4.92e-08

Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport and metabolism];


Pssm-ID: 442578  Cd Length: 56  Bit Score: 50.47  E-value: 4.92e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767942186  206 GDTKHFCPVVLKEnfiLQPGNTEEAAKYREKIYYFSSAEAKEKFLEHPEDYVAHEE 261
Cdd:COG3350     3 GVAMVIDPVCGMT---VDPGSAAYTAEYDGKTYYFCSEECRDKFKANPEKYLPQYG 55
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 269-437 6.00e-08

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 54.55  E-value: 6.00e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186   269 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEklllktekkvgpEFEEDSENEQAAKQELEelaiqanvkveeent 348
Cdd:TIGR01351    1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRA------------EIKAGTPLGKKAKEYME--------------- 53

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186   349 KKQLpevqlteeeeviksslmenepLPPEILEVILSEWWLKEPIRSTGFILDGFPRYPEEAQFLGDRGFFP-DAAVFIQV 427
Cdd:TIGR01351   54 KGEL---------------------VPDEIVNQLVKERLTQNDDNENGFILDGFPRTLSQAEALDALLEEPiDAVIELDV 112

                          170
                   ....*....|
gi 767942186   428 DDQDIFDRLL 437
Cdd:TIGR01351  113 PDEELVERLS 122
adk PRK02496
adenylate kinase; Provisional
 269-437 3.61e-07

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 51.67  E-value: 3.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  269 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQeklllktekkvgpefeedseneqAAKQELEELAIQANvkveeent 348
Cdd:PRK02496    3 RLIFLGPPGAGKGTQAVVLAEHLHIPHISTGDILR-----------------------QAIKEQTPLGIKAQ-------- 51

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  349 kkqlpevqlteeeeviksSLMENEPLPPEILEVILSEWWLKEPIRSTGFILDGFPRYPEEAQFL-------GDRGffpDA 421
Cdd:PRK02496   52 ------------------GYMDKGELVPDQLVLDLVQERLQQPDAANGWILDGFPRKVTQAAFLdellqeiGQSG---ER 110

                         170
                  ....*....|....*.
gi 767942186  422 AVFIQVDDQDIFDRLL 437
Cdd:PRK02496  111 VVNLDVPDDVVVERLL 126
AAA_17 pfam13207
AAA domain;
273-437 4.31e-07

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 50.32  E-value: 4.31e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186   273 VGPQGSGK-TMCgRQLAEKLNIFHIQFEEVLqeklllktekkvgpeFEEdseneqAAKQELEElaiqanvkveeenTKKQ 351
Cdd:pfam13207    1 TGVPGSGKtTQL-KKLAEKLGFPHISAGDLL---------------REE------AKERGLVE-------------DRDE 45

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186   352 LPEVQLTEEEEVIKsslmeneplppEILEVIlsewwlKEPIRSTGFILDGFPRYPEEAQFLGD------RGFFPDAAVFI 425
Cdd:pfam13207   46 MRKLPLEPQKELQK-----------LAAERI------AEEAGEGGVIVDGHPRIKTPAGYLPGlpvevlRELKPDAIILL 108

                          170
                   ....*....|..
gi 767942186   426 QVDDQDIFDRLL 437
Cdd:pfam13207  109 EADPEEILERRL 120
PRK14532 PRK14532
adenylate kinase; Provisional
 690-857 6.88e-07

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 50.98  E-value: 6.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  690 IIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGGALRYVLNNHpeTELALMLNWHLHKGMTAPDELAIQALELSLMES 769
Cdd:PRK14532    3 LILFGPPAAGKGT-----QAKRLVEERGMVQLSTGDMLRAAIASG--SELGQRVKGIMDRGELVSDEIVIALIEERLPEA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  770 VcNTAGVVIDGYPVTKHQMN----LLEARSIIPMVIFELSVPSKEIFKRLLLEKENEQRlpyPLHNSAQIVaVNNVKYRK 845
Cdd:PRK14532   76 E-AAGGAIFDGFPRTVAQAEaldkMLASRGQKIDVVIRLKVDDEALIERIVKRFEEQGR---PDDNPEVFV-TRLDAYNA 150

                         170
                  ....*....|..
gi 767942186  846 NIGEIRQYYQEQ 857
Cdd:PRK14532  151 QTAPLLPYYAGQ 162
adk PRK02496
adenylate kinase; Provisional
 688-866 9.90e-07

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 50.52  E-value: 9.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  688 IRIIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLM 767
Cdd:PRK02496    2 TRLIFLGPPGAGKGT-----QAVVLAEHLHIPHISTGDILRQAIKE--QTPLGIKAQGYMDKGELVPDQLVLDLVQERLQ 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  768 ESvcNTA-GVVIDGYPVTKHQMNLLEA----------RSIipmvifELSVPSKEIFKRLLL---EKENEQrlpyPLHNSA 833
Cdd:PRK02496   75 QP--DAAnGWILDGFPRKVTQAAFLDEllqeigqsgeRVV------NLDVPDDVVVERLLArgrKDDTEE----VIRRRL 142

                         170       180       190
                  ....*....|....*....|....*....|...
gi 767942186  834 QIvavnnvkYRKNIGEIRQYYQEQHQnWYVIDG 866
Cdd:PRK02496  143 EV-------YREQTAPLIDYYRDRQK-LLTIDG 167
ADK pfam00406
Adenylate kinase;
272-437 4.10e-06

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 48.46  E-value: 4.10e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186   272 LVGPQGSGK-TMCGRqLAEKLNIFHIQFEEVLQEklllktekkvgpefeedsenEQAAKQELEELAiqanvkveeentKK 350
Cdd:pfam00406    1 LLGPPGAGKgTQAEK-IVQKYGLPHLSTGDLLRA--------------------EIKSGTELGKEA------------KE 47

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186   351 QLPEVQLTEEEEVIKssLMENEplppeilevilsewwLKEPIRSTGFILDGFPRYPEEAQFLGD---RGFFPDAAVFIQV 427
Cdd:pfam00406   48 YMDKGELVPDEVVVG--LVKER---------------LEQNDCKNGFLLDGFPRTVPQAEALEElleRGIKLDYVIEFDV 110

                          170
                   ....*....|
gi 767942186   428 DDQDIFDRLL 437
Cdd:pfam00406  111 PDEVLVERLT 120
PLN02842 PLN02842
nucleotide kinase
 691-814 8.85e-06

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 49.86  E-value: 8.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  691 IIVGPPKSGKTTvLCFSVAKKitseYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESV 770
Cdd:PLN02842    1 MISGAPASGKGT-QCELIVHK----FGLVHISTGDLLRAEVSA--GTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSRED 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 767942186  771 CNTAGVVIDGYPVTKHQMNLLEARSIIPMVIFELSVPSKEIFKR 814
Cdd:PLN02842   74 AKEKGWLLDGYPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDR 117
adk PRK00279
adenylate kinase; Reviewed
 268-437 1.00e-05

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 47.84  E-value: 1.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  268 LRICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQeklllktekkvgpefeedseneqaakqeleelaiqANVKVEEEN 347
Cdd:PRK00279    1 MRLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLR-----------------------------------AAVKAGTEL 45

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  348 TKKqlpevqlteeeevIKSsLMEN-EPLPPEILEVILSEWwLKEPIRSTGFILDGFPRYPEEAQ----FLGDRGFFPDAA 422
Cdd:PRK00279   46 GKE-------------AKS-YMDAgELVPDEIVIGLVKER-LAQPDCKNGFLLDGFPRTIPQAEaldeMLKELGIKLDAV 110

                         170
                  ....*....|....*
gi 767942186  423 VFIQVDDQDIFDRLL 437
Cdd:PRK00279  111 IEIDVPDEELVERLS 125
PLN02674 PLN02674
adenylate kinase
 689-792 6.24e-05

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 46.03  E-value: 6.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  689 RIIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGGALRYVLNnhPETELALMLNWHLHKGMTAPDELAIQALELSLME 768
Cdd:PLN02674   33 RLILIGPPGSGKGT-----QSPIIKDEYCLCHLATGDMLRAAVA--AKTPLGIKAKEAMDKGELVSDDLVVGIIDEAMKK 105

                          90       100
                  ....*....|....*....|....
gi 767942186  769 SVCNTaGVVIDGYPVTKHQMNLLE 792
Cdd:PLN02674  106 PSCQK-GFILDGFPRTVVQAQKLD 128
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 687-816 9.54e-05

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 45.18  E-value: 9.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  687 PIRIIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSL 766
Cdd:PTZ00088    6 PLKIVLFGAPGVGKGT-----FAEILSKKENLKHINMGNILREEIKA--KTTIGKEIQKVVTSGNLVPDNLVIAIVKDEI 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767942186  767 MESV-CNTAGVVIDGYPVTKHQMNLLEARSIIPMVIfELSVPSKEIFKRLL 816
Cdd:PTZ00088   79 AKVTdDCFKGFILDGFPRNLKQCKELGKITNIDLFV-NIYLPRNILIKKLL 128
PRK14531 PRK14531
adenylate kinase; Provisional
 689-816 9.61e-05

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 44.42  E-value: 9.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  689 RIIIVGPPKSGKTTVlcfsvAKKITSEYGLKHLSIGGALRYVLNnhPETELALMLNWHLHKGmtapdELAIQALELSLME 768
Cdd:PRK14531    4 RLLFLGPPGAGKGTQ-----AARLCAAHGLRHLSTGDLLRSEVA--AGSALGQEAEAVMNRG-----ELVSDALVLAIVE 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767942186  769 S---VCNTAGVVIDGYPVTKHQMNLLEA------RSIIPMVIFELSvpSKEIFKRLL 816
Cdd:PRK14531   72 SqlkALNSGGWLLDGFPRTVAQAEALEPlleelkQPIEAVVLLELD--DAVLIERLL 126
AAA_18 pfam13238
AAA domain;
270-343 2.30e-04

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 42.42  E-value: 2.30e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767942186   270 ICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEKLLLKTEKKVGPEFEEDSENEQAAKQELEELAIQANVKV 343
Cdd:pfam13238    1 ILITGTPGVGKTTLAKELSKRLGFGDNVRDLALENGLVLGDDPETRESKRLDEDKLDRLLDLLEENAALEEGGN 74
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 690-824 3.29e-04

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 43.13  E-value: 3.29e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186   690 IIIVGPPKSGKTTVlCfsvaKKITSEYGLKHLSIGGALRYVLNNHPETELALMLNwHLHKGMTAPDELAIQALElSLMES 769
Cdd:TIGR01359    2 VFVLGGPGSGKGTQ-C----AKIVENFGFTHLSAGDLLRAEIKREGSENGSLIES-YIKEGKIVPSEVTVELLK-KAIQE 74

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186   770 VCNTAGVVIDGYPvtKHQMNL-----LEARSIIPMVIFELSVPSKEIFKRLLLEKENEQR 824
Cdd:TIGR01359   75 DGSSKKFLIDGFP--RNEENLeawekLMDNKVNFKFVLFFDCPEETMIKRLLKRGQTSGR 132
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 244-314 3.70e-04

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 44.52  E-value: 3.70e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767942186  244 EAKEKFLEHPEDYVAHEEPlkaPPLRICLVGPQGSGKTMCGRQLAEKL--NIFHIQFEEVLQeKLLLKTEKKV 314
Cdd:COG0464   171 ELVALPLKRPELREEYGLP---PPRGLLLYGPPGTGKTLLARALAGELglPLIEVDLSDLVS-KYVGETEKNL 239
cyt_kin_arch TIGR02173
cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. ...
 690-728 3.72e-04

cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. Members of this family are found in the archaea and in spirochaetes, and differ considerably from the common bacterial form of cytidylate kinase described by TIGR00017.


Pssm-ID: 274012 [Multi-domain]  Cd Length: 171  Bit Score: 42.41  E-value: 3.72e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767942186   690 IIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGGALR 728
Cdd:TIGR02173    3 ITISGPPGSGKTT-----VAKILAEKLSLKLISAGDIFR 36
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 266-320 5.42e-04

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 41.88  E-value: 5.42e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767942186  266 PPLRICLVGPQGSGKTMCGRQLAEKLNI--FHIQFEEvLQEKLLLKTEKKVGPEFEE 320
Cdd:cd19481    25 LPKGILLYGPPGTGKTLLAKALAGELGLplIVVKLSS-LLSKYVGESEKNLRKIFER 80
PRK04182 PRK04182
cytidylate kinase; Provisional
 689-724 1.13e-03

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 41.33  E-value: 1.13e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 767942186  689 RIIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIG 724
Cdd:PRK04182    2 IITISGPPGSGKTT-----VARLLAEKLGLKHVSAG 32
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
242-306 1.69e-03

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 41.41  E-value: 1.69e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  242 SAEAKEKFLEHPEDYVAHEEPLK---APPLRICLVGPQGSGKTMCGRQLAEKLN--IFHIQFEEVLQEKL 306
Cdd:COG1223     7 QEEAKKKLKLIIKELRRRENLRKfglWPPRKILFYGPPGTGKTMLAEALAGELKlpLLTVRLDSLIGSYL 76
PRK13951 PRK13951
bifunctional shikimate kinase AroK/3-dehydroquinate synthase AroB;
268-386 2.50e-03

bifunctional shikimate kinase AroK/3-dehydroquinate synthase AroB;


Pssm-ID: 172457 [Multi-domain]  Cd Length: 488  Bit Score: 41.81  E-value: 2.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  268 LRICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEklllKTEKKVGPEFEEDSEN--EQAAKQELEELAIQANVKV-- 343
Cdd:PRK13951    1 MRIFLVGMMGSGKSTIGKRVSEVLDLQFIDMDEEIER----REGRSVRRIFEEDGEEyfRLKEKELLRELVERDNVVVat 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767942186  344 --------EEENTKKQLPEVQLTEEEEVIKSSL-MENEPLPPEILEVILSEW 386
Cdd:PRK13951   77 gggvvidpENRELLKKEKTLFLYAPPEVLMERVtTENRPLLREGKERIREIW 128
FAP206 pfam12018
Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There ...
 211-259 4.55e-03

Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There are two conserved sequence motifs: GFC and GLL. This family is also known as UPF0704. This domain is found in FAP206, a protein associated with cilia and flagella. In the ciliate Tetrahymena, the cilium has radial spokes, each of which is a macromolecular complex essential for motility. A triplet of three radial spokes, RS1, RS2, and RS3, is repeated every 96 nm along the doublet microtubule. Each spoke has a distinct base that docks to the doublet and is linked to different inner dynein arms. Knockout of the FAP206 gene results in slow cell motility and the 96-nm repeats lack RS2 and dynein c. FAP206 is probably part of the front prong and docks RS2 and dynein c to the microtubule.


Pssm-ID: 463432  Cd Length: 273  Bit Score: 40.33  E-value: 4.55e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767942186   211 FCPVVL-KENFILQPGNTE-EAAKYREKIYYFSSAEAKEKFLEHPEDYVAH 259
Cdd:pfam12018  201 FCAWTLvVRDGLLLPGNPSiGVLKYKDKYYAFSSKEAAYEFASDPDRFIAA 251
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 689-725 5.33e-03

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 38.62  E-value: 5.33e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 767942186  689 RIIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGG 725
Cdd:cd02020     1 IIAIDGPAGSGKST-----VAKLLAKKLGLPYLDTGG 32
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 266-343 5.52e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 38.89  E-value: 5.52e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186    266 PPLRICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEV----LQEKLLLKTEKKVGPEFEEDSENEQAAKQeLEELAIQANV 341
Cdd:smart00382    1 PGEVILIVGPPGSGKTTLARALARELGPPGGGVIYIdgedILEEVLDQLLLIIVGGKKASGSGELRLRL-ALALARKLKP 79


                    ..
gi 767942186    342 KV 343
Cdd:smart00382   80 DV 81
PRK14526 PRK14526
adenylate kinase; Provisional
 688-792 6.64e-03

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 39.45  E-value: 6.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942186  688 IRIIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALElSLM 767
Cdd:PRK14526    1 MKLVFLGPPGSGKGT-----IAKILSNELNYYHISTGDLFRENILN--STPLGKEIKQIVENGQLVPDSITIKIVE-DKI 72

                          90       100
                  ....*....|....*....|....*
gi 767942186  768 ESVCNTAGVVIDGYPVTKHQMNLLE 792
Cdd:PRK14526   73 NTIKNNDNFILDGFPRNINQAKALD 97
YHS COG3350
Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport ...
 628-680 9.62e-03

Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport and metabolism];


Pssm-ID: 442578  Cd Length: 56  Bit Score: 35.45  E-value: 9.62e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767942186  628 DPVklsEGETIKPVENAenpiYPVIHRQYIYFLSSKETKEKFMKNPIKYIRQP 680
Cdd:COG3350     9 DPV---CGMTVDPGSAA----YTAEYDGKTYYFCSEECRDKFKANPEKYLPQY 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH