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Conserved domains on  [gi|767943787|ref|XP_011534514|]
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solute carrier family 22 member 16 isoform X10 [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-295 3.92e-130

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17375:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 341  Bit Score: 375.24  E-value: 3.92e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787   1 MEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPetpfwllsegryeeaqkivdi 80
Cdd:cd17375  114 TEFTGIKARTWASMHVHAFFAVGIMVVALVGYLVRTWWIYQIILSLVTIPFILCCWMLP--------------------- 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787  81 makwnrasscklsellsldlqgpvsnsptevqkhnlsylfynwsitKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLN 160
Cdd:cd17375  173 ----------------------------------------------KRTITVWLIWFTGSLGYYVFSLGSVNLGGNEYLN 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 161 LFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYP 240
Cdd:cd17375  207 LFLVGAVEIPSYIIACIGMDKLGRRNTLAPFLLLSALACMLIMVIPQDYEVLTIVLSMTGKFAIAIAFGLIYLYTAELYP 286

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767943787 241 TIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLP 295
Cdd:cd17375  287 TIVRSLAVGSGSMMCRVGSVVAPFCVYLSDVWIFLPQLLVGIMAFLSGILTLMLP 341
 
Name Accession Description Interval E-value
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
 1-295 3.92e-130

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 375.24  E-value: 3.92e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787   1 MEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPetpfwllsegryeeaqkivdi 80
Cdd:cd17375  114 TEFTGIKARTWASMHVHAFFAVGIMVVALVGYLVRTWWIYQIILSLVTIPFILCCWMLP--------------------- 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787  81 makwnrasscklsellsldlqgpvsnsptevqkhnlsylfynwsitKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLN 160
Cdd:cd17375  173 ----------------------------------------------KRTITVWLIWFTGSLGYYVFSLGSVNLGGNEYLN 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 161 LFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYP 240
Cdd:cd17375  207 LFLVGAVEIPSYIIACIGMDKLGRRNTLAPFLLLSALACMLIMVIPQDYEVLTIVLSMTGKFAIAIAFGLIYLYTAELYP 286

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767943787 241 TIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLP 295
Cdd:cd17375  287 TIVRSLAVGSGSMMCRVGSVVAPFCVYLSDVWIFLPQLLVGIMAFLSGILTLMLP 341
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 2-305 8.87e-75

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 239.15  E-value: 8.87e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787    2 EFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWwlyQMILSTVTVPFILC---CWVLPETPFWLLSEGRYEEAQKIV 78
Cdd:TIGR00898 207 EFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPDW---RWLQLAVSLPTFLFfllSWFVPESPRWLISQGRIEEALKIL 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787   79 DIMAKWNRASscKLSELLSLDLQGPVSNSPtevQKHNLSYLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEY 158
Cdd:TIGR00898 284 QRIAKINGKK--LPAEVLSLSLEKDLSSSK---KQYSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNIY 358

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787  159 LNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAEL 238
Cdd:TIGR00898 359 LDLFISGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFVPVDLYFLRTALAVLGKFGITSAFQMVYLYTAEL 438

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767943787  239 YPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATT 305
Cdd:TIGR00898 439 YPTVVRNLGVGVCSTMARVGSIISPFLVYLGEKWLFLPLVLFGGLALLAGILTLFLPETKGVPLPET 505
Sugar_tr pfam00083
Sugar (and other) transporter;
18-302 2.40e-13

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 70.38  E-value: 2.40e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787   18 SFFAVGTLLVALTGYLVRT------WWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIVDIMAKWNRASSCK 91
Cdd:pfam00083 145 LAITFGILLAYIFGLGLNKtsnsdgWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKLRGVPDVDREL 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787   92 LSELLSLDLQgpvsnspTEVQKHNLSYLFYNWSITKRTLTVWLIW----FTG--SLGFYSFSL-NSVNLGGNEYLNlFLL 164
Cdd:pfam00083 225 DEIKDSLEAG-------QEAEKASWKELFSTKTRRQRLLIGVMLQifqqLTGinAIFYYSTTIfENLGLSDSFLVT-IIV 296

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787  165 GVVEIpAYTFVCI-AMDKVGRRTVLAYSLF----CSALACGVVMVIPQKHYILGVVTA-----MVGKFAIGAAfGLIYLY 234
Cdd:pfam00083 297 GVVNF-VFTFIAIfLVDRFGRRPLLLLGAAgmaiCFVILGIVALLGVSKSDWAGIVAIvfialFIAFFAMGWG-PVPWVI 374

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767943787  235 TAELYPTIVRSLAVGSGSMVCRLASILA----PFSVDLSSIWiFIPQLFVGTMALLSGVLTLKLPETLGKRL 302
Cdd:pfam00083 375 VSELFPLSVRSKAMALATAANWLANFLIgflfPIITDAIGLG-YTFFIFAGLLVLFIIFVFFFVPETKGRTL 445
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
128-300 1.15e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 52.95  E-value: 1.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 128 RTLTVWLIWFTGSLGFYSFSLNSVNLGGNEY-LNLFLLGVVEIPAYTFVCIAM-------DKVGRRTVLAYSLFCSALAC 199
Cdd:COG2271  181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVRgLSLAQAGLLLSLPFLAGIVGSllggwlsDRLGRRRKLVLAIGLLLAAL 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 200 GVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAP----FSVDLSSIWIFI 275
Cdd:COG2271  261 ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPllvgYLLDATGYQAAF 340

                        170       180
                 ....*....|....*....|....*
gi 767943787 276 pqLFVGTMALLSGVLTLKLPETLGK 300
Cdd:COG2271  341 --LLLAALALLAALLALLLLRETRK 363
 
Name Accession Description Interval E-value
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
 1-295 3.92e-130

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 375.24  E-value: 3.92e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787   1 MEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPetpfwllsegryeeaqkivdi 80
Cdd:cd17375  114 TEFTGIKARTWASMHVHAFFAVGIMVVALVGYLVRTWWIYQIILSLVTIPFILCCWMLP--------------------- 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787  81 makwnrasscklsellsldlqgpvsnsptevqkhnlsylfynwsitKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLN 160
Cdd:cd17375  173 ----------------------------------------------KRTITVWLIWFTGSLGYYVFSLGSVNLGGNEYLN 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 161 LFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYP 240
Cdd:cd17375  207 LFLVGAVEIPSYIIACIGMDKLGRRNTLAPFLLLSALACMLIMVIPQDYEVLTIVLSMTGKFAIAIAFGLIYLYTAELYP 286

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767943787 241 TIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLP 295
Cdd:cd17375  287 TIVRSLAVGSGSMMCRVGSVVAPFCVYLSDVWIFLPQLLVGIMAFLSGILTLMLP 341
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 2-305 8.87e-75

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 239.15  E-value: 8.87e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787    2 EFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWwlyQMILSTVTVPFILC---CWVLPETPFWLLSEGRYEEAQKIV 78
Cdd:TIGR00898 207 EFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPDW---RWLQLAVSLPTFLFfllSWFVPESPRWLISQGRIEEALKIL 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787   79 DIMAKWNRASscKLSELLSLDLQGPVSNSPtevQKHNLSYLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEY 158
Cdd:TIGR00898 284 QRIAKINGKK--LPAEVLSLSLEKDLSSSK---KQYSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNIY 358

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787  159 LNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAEL 238
Cdd:TIGR00898 359 LDLFISGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFVPVDLYFLRTALAVLGKFGITSAFQMVYLYTAEL 438

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767943787  239 YPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATT 305
Cdd:TIGR00898 439 YPTVVRNLGVGVCSTMARVGSIISPFLVYLGEKWLFLPLVLFGGLALLAGILTLFLPETKGVPLPET 505
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 1-295 1.57e-74

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 233.24  E-value: 1.57e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787   1 MEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPetpfwllsegryeeaqkivdi 80
Cdd:cd17317  104 MEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLLLWWLP--------------------- 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787  81 makwnrasscklsellsldlqgpvsnsptevqkhnlsylfynwsitKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLN 160
Cdd:cd17317  163 ----------------------------------------------RRTIIVGLIWFVTSLVYYGLSLNSSNLGGNLYLN 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 161 LFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYP 240
Cdd:cd17317  197 FFLSGLVEIPAYFLALLLLDRLGRRWTLSGSLLLAGLACLVTALLPDDENTLALTLALVGKFAISAAFSVIYLYTAELYP 276

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767943787 241 TIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLP 295
Cdd:cd17317  277 TVVRNTGVGLCSTVARVGAILAPFIVLLGKIGPLLPLIIFGVLALLGGLLTLLLP 331
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 1-295 1.04e-40

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 145.90  E-value: 1.04e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787   1 MEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPetpfwllsegryeeaqkivdi 80
Cdd:cd17374  114 TEWTTPRHRALAITLTSCFFSIGQMLLAGLAYAIRDWRLLQLVVSVPFFLFFLYSWWLP--------------------- 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787  81 makwnrasscklsellsldlqgpvsnsptevqkhnlsylfynwsitKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLN 160
Cdd:cd17374  173 ----------------------------------------------KRTLILSFVWFANSFSYYGLSLDLQHLGLNVFLL 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 161 LFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYP 240
Cdd:cd17374  207 QFLFGAVEVPARCLALFLLNHMGRRISQAVLLLLAGLCILANIFVPQEMQTLRTVLAVLGKGSSAAAFTISYVYTAELFP 286

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767943787 241 TIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLP 295
Cdd:cd17374  287 TVLRQTGMGLNSMFARIGGILAPLIMLLGVYSPLLPMIIYGVLPILAGLLALLLP 341
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
 123-295 3.50e-39

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 141.83  E-value: 3.50e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 123 WSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVV 202
Cdd:cd17376  170 WFIPITTIMSLLLWMAISVGYFGLSLNTPNLHGDPYLNCFLSAVIEVPAYIIAWLLLRSLPRRYSIAATLVLGGGVLLFI 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 203 MVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGT 282
Cdd:cd17376  250 QLVPTDLQVLATALVMLGKFGITAAFSMVYVYTAELYPTVVRNMGVGVCSTASRIGSIISPYFVYLGAYDRYLPYILMGS 329

                        170
                 ....*....|...
gi 767943787 283 MALLSGVLTLKLP 295
Cdd:cd17376  330 LTVLIGILTLFLP 342
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 125-295 1.06e-35

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 132.59  E-value: 1.06e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 125 ITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDK--VGRRTVLAYSLFCSALACGVV 202
Cdd:cd17377  175 IPGRTLILMYVWFVCSLVYYGLTLNAGDLGGNIYLNLALSGLVELPAYPLCIYLINQkwSGRRRTLAGFLFLGGIACLLV 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 203 MVIPQKH--YILGVVT----AMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIP 276
Cdd:cd17377  255 MFVPEKKdsGVFAVVNstslSLLGKLTISAAFNIVYIYTSELYPTVVRNAGLGVCSMFSRVGGIIAPFIPSLKSVQWSLP 334

                        170
                 ....*....|....*....
gi 767943787 277 QLFVGTMALLSGVLTLKLP 295
Cdd:cd17377  335 FIVFGASGLSAGLLSLLLP 353
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 2-295 3.28e-31

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 120.53  E-value: 3.28e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787   2 EFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMilsTVTVPFILccwvlpetpfwllsegryeeaqkivdim 81
Cdd:cd17379  113 EFVGSKYRRTVGIVYQMFFTLGLLILPGIAYFIPHWRWLQL---AVTLPNFL---------------------------- 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787  82 akwnrasscklsellsldlqgpvsnsptevqkhnlsYLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNL 161
Cdd:cd17379  162 ------------------------------------FLLYYWFIPKHTFILMYAWFTSAVVYQGLIMRLGITGGNLYLDF 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 162 FLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPT 241
Cdd:cd17379  206 FISALVELPAAFIILLTIDRIGRRLPFAASNIVAGAACLITAFIPPDLHWLKTTIACVGRLGITMAFEIVCLVNTELYPT 285

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767943787 242 IVRSLAVGSGSMVCRLASILAPFSV-DLSSIWIFIPQLFVGTMALLSGVLTLKLP 295
Cdd:cd17379  286 FLRNLGVSVCSSLCDIGGIIAPFLLyRLAEIWLELPLIVFGVLALVAGGLVLLLP 340
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
 1-295 2.32e-30

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 117.91  E-value: 2.32e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787   1 MEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPetpfwllsegryeeaqkivdi 80
Cdd:cd17447  114 VEWVDIEHRTVAGVLISLFWTVGNMLLALVAYLIRDWRWLILAVTLPCAPGIITWWWVP--------------------- 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787  81 makwnrasscklsellsldlqgpvsnsptevqkhnlsylfynwsitKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLN 160
Cdd:cd17447  173 ----------------------------------------------KISLCTGIVWFGVAFTYYGISFNISGFGLNVYLT 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 161 LFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYP 240
Cdd:cd17447  207 QFIYGAIELPAKLLAYLLLDRIGRRLTQAGSLILTGLSIGINILIPSEFTVVRTVIAVLGKGFSEAAFTTVFLYTSELYP 286

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767943787 241 TIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLP 295
Cdd:cd17447  287 TVLRQNGMGYTSFIARLGGSLAPLVILLDDVWLSLPQVIFCGVALLAGGVAFLLP 341
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
 118-295 1.13e-27

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 110.58  E-value: 1.13e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 118 YLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSAL 197
Cdd:cd17446  162 FFLYSWWFPRITFCLSLVWFSTSFAYYGLAMDLQKFGVSIYLIQIIFGAVDIPAKFISTLTMSYLGRRPTQAAALILAGI 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 198 ACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQ 277
Cdd:cd17446  242 MILANIFVPQDLQTVRTALAVFGKGCLAASFNCVYLYTGELYPTVIRQTGMGLGSTMARLGGIVAPLVKMLGEYYPFLPL 321

                        170
                 ....*....|....*...
gi 767943787 278 LFVGTMALLSGVLTLKLP 295
Cdd:cd17446  322 IIYGAAPILSGIAACFLP 339
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
 115-295 2.73e-22

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 95.89  E-value: 2.73e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 115 NLSYLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFC 194
Cdd:cd17378  161 ALIYCILVYLFARRLLAVMVIGFGIGMVYYGIPLAVGNLKFNIYLSVALNALSELPAFVITAFLLDRFGRRPSLLGFTLL 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 195 SALACGVVMVIPQKHYI-LGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWI 273
Cdd:cd17378  241 SGASCLLCFVLSIGGTTsLQIALELVGFFGAAGAFNLLYIYTVELFPTCVRNAALGMLRQALVVGGIFAPFIVSLGRKNA 320

                        170       180
                 ....*....|....*....|..
gi 767943787 274 FIPQLFVGTMALLSGVLTLKLP 295
Cdd:cd17378  321 ALSFGVFGVAILLLGLFALGLP 342
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 119-289 4.70e-15

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 75.26  E-value: 4.70e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 119 LFYNWsITKRTLTVWLIWFTGSLGFYSFSLNSV---------------------------NLGGNEYLNLFLLGVVEIPA 171
Cdd:cd17372  167 VFYRW-TPKTTLLLWVIWFGNAFAYYGVVLLTTelnnshnvcgsksdsdsgesptekqcrNSNDVDYRDVFIATFAEFPG 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 172 YTFVCIAMDKVGRRTVLAYSLFCSALaCGVVMVIPQKHYILGVVTAMvGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSG 251
Cdd:cd17372  246 LLISAAMIDRLGRKASMASMLFTCCI-FLLLLLICQSPFILTVLLFG-GRACISAAFTVVYIYTPEVYPTAVRALGVGTG 323

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 767943787 252 SMVCRLASILAPF-SVDLSSIWIFIPQLFVGTMALLSGV 289
Cdd:cd17372  324 SSVGRIGAILCPFiAQVLVHGSQTIALLLFSVVCLVSAI 362
Sugar_tr pfam00083
Sugar (and other) transporter;
18-302 2.40e-13

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 70.38  E-value: 2.40e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787   18 SFFAVGTLLVALTGYLVRT------WWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIVDIMAKWNRASSCK 91
Cdd:pfam00083 145 LAITFGILLAYIFGLGLNKtsnsdgWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKLRGVPDVDREL 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787   92 LSELLSLDLQgpvsnspTEVQKHNLSYLFYNWSITKRTLTVWLIW----FTG--SLGFYSFSL-NSVNLGGNEYLNlFLL 164
Cdd:pfam00083 225 DEIKDSLEAG-------QEAEKASWKELFSTKTRRQRLLIGVMLQifqqLTGinAIFYYSTTIfENLGLSDSFLVT-IIV 296

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787  165 GVVEIpAYTFVCI-AMDKVGRRTVLAYSLF----CSALACGVVMVIPQKHYILGVVTA-----MVGKFAIGAAfGLIYLY 234
Cdd:pfam00083 297 GVVNF-VFTFIAIfLVDRFGRRPLLLLGAAgmaiCFVILGIVALLGVSKSDWAGIVAIvfialFIAFFAMGWG-PVPWVI 374

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767943787  235 TAELYPTIVRSLAVGSGSMVCRLASILA----PFSVDLSSIWiFIPQLFVGTMALLSGVLTLKLPETLGKRL 302
Cdd:pfam00083 375 VSELFPLSVRSKAMALATAANWLANFLIgflfPIITDAIGLG-YTFFIFAGLLVLFIIFVFFFVPETKGRTL 445
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 127-292 8.40e-13

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 68.40  E-value: 8.40e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 127 KRTLTVWLIWFTGSLGFY-------SFSLNSVNLGGNE-YLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALA 198
Cdd:cd17316  177 RRTLLLILLWFFISFGYYglttflpTYLQTVLGLSPATsSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGIL 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 199 CGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDL---SSIWIFI 275
Cdd:cd17316  257 ALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALllaSTGGTGV 336

                        170
                 ....*....|....*..
gi 767943787 276 PQLFVGTMALLSGVLTL 292
Cdd:cd17316  337 PALILALLAIVALIVAL 353
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 158-302 6.14e-10

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 60.38  E-value: 6.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787  158 YLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVtAMVGKFAIgAAFGLIYLYTAE 237
Cdd:TIGR01299 598 YFVNFLGTLAVLPGNIVSALLMDKIGRLRMLAGSMVLSCISCFFLSFGNSESAMIALL-CLFGGLSI-AAWNALDVLTVE 675

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767943787  238 LYPTIVRSLAVGSGSMVCRLASILA-PFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRL 302
Cdd:TIGR01299 676 LYPSDKRATAFGFLNALCKAAAVLGiLIFGSFVGITKAAPILFASAALACGGLLALKLPDTRGQVL 741
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 49-305 7.43e-10

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 60.05  E-value: 7.43e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787   49 VPFILCCWVLPETPFWLLSEGRYEEAQKIVdimAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLF-----YNW 123
Cdd:TIGR00879 207 GLLFLGLFFLPESPRWLVGKGRVEEARKSL---ARLRGTSGEDKELLDELELIDIKRSIEKRSVQPSWGSLFsstrrIRR 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787  124 SITKRTLTVWLIWFTGSLGFYSFSLNSVNLGG----NEYLNLFLLGVVEIpAYTFVCI-AMDKVGRRTVLAYSLFCSALA 198
Cdd:TIGR00879 284 RLFLGVVLQWFQQFTGINAIMYYSPTIFENAGvstdHAFLVSIIVGAVNF-AFTFVAIfLVDRFGRRPLLLIGAAGMAIC 362

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787  199 ------CGVVMVIPQKHYILGVVTAMVGKFAIGAAFG---LIYLYTAELYPTIVRSLAVGSGSMVCRLASIL--APFSVD 267
Cdd:TIGR00879 363 lfvlgiLGASFVTGSSKSSGNVAIVFILLFIAFFAMGwgpVPWVIVSEIFPLSLRPKGISIAVAANWLANFIvgFLFPTM 442

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 767943787  268 LSSIWIFIPQLFVGTMALLSGVLT-LKLPETLGKRLATT 305
Cdd:TIGR00879 443 LESIGVGGVFIFFGGLNVLGLIFVyFFLPETKGRTLEEI 481
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
 125-289 1.11e-09

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 59.05  E-value: 1.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 125 ITKRTLTVWLIWFTGSLGFYSFSLNSVNL--------------------------------GGNEYLNLFLLGVVEIPAY 172
Cdd:cd17442  174 IPRTTLQIWVIWLGISFAYYGVILASSELlernllcgsdpsdeeagikhiesespcychmfNPSDYQTMIISTLGEIALN 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 173 TFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGkfAIGAAFGLIYLYTAELYPTIVRSLAVGSGS 252
Cdd:cd17442  254 PLNILGINFLGRRLSLVITMGLTAIFFLLLNICTSSAGLTIFLFMLRA--LVSANFNTVYIYTAEVYPTTMRALGMGTSG 331

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 767943787 253 MVCRLASILAPFSVDlssiwIFIPQLFVGTMALLSGV 289
Cdd:cd17442  332 SLCRIGAMVAPFISQ-----VLMSASVLGALCLFSSV 363
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 1-300 2.43e-09

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 58.43  E-value: 2.43e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787   1 MEFIGMKSRTWASVHLHSFFAVGTLLVALTGY-----LVRTWWLyqmILSTVTVPFILCC---WVLPETPFWLL-SEGRY 71
Cdd:cd17357  131 QEISPSELRGALGSLTQIGVTLGILLGQVFGLpsvlgTETLWPY---LLFFPGIPALLQLaalPFFPESPKFLLiSKGDE 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787  72 EEAQKIVDIMAKWNRASSCKLSELLSLDLQgpvsNSPTEVQKhnLSYLFYNWSITKRTLTVWLIWFTGSL-GFYSFSLNS 150
Cdd:cd17357  208 EEAEKSLKFLRGIEDDVDQELEEIKKESEQ----MGDQKQVS--LMQLLRDPSLRLPLLLVLVVSASQQFsGINAIFFYS 281

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 151 VNLGGN--------EYLNLFLlGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACgVVMVIPQKHYILGVVTAMvgkF 222
Cdd:cd17357  282 TFIFENagfspqlaEWANLGI-GIVNVLSTIVGPFLIEKVGRRPLLLISLSVCAVAL-LLMSVFLFLSEQNSWMSY---G 356

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 223 AIGAAFGLIYLY-----------TAELYPTIVRSLAVGSGSMVCRLASILAPFSV----DLSSIWIFIPqlFVGTMALLS 287
Cdd:cd17357  357 CIVAIFLFIFFFaiglgpipwfiGAELFPQAPRSAAQSLGSSVNWTSNFIVGMAFpplqSIGGGFVFII--FAIPCALFL 434

                        330
                 ....*....|...
gi 767943787 288 GVLTLKLPETLGK 300
Cdd:cd17357  435 LYLYRYLPETKGR 447
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 22-302 8.54e-09

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 56.43  E-value: 8.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787  22 VGTLLVALTGYLVRtWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIVdimaKWNRASSCKLSELLSLDLQ 101
Cdd:cd17358  141 IGILLGYVLGSFLP-WRTLALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSL----QFLRGKDADISKEAAEIQE 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 102 gpvSNSPTEVQKHNLSYLFYNWSITKRTLTVWLIW-----FTGSLG--FYSFS-LNSVNLGGNEYLNLFLLGVVEIPAYT 173
Cdd:cd17358  216 ---ELAELEKEAKESSFSDLFQRKYLKPLVIGLGLmlfqqLSGINAviFYASSiFDEAGSGLDPNTATIIIGVVQVVGTL 292

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 174 FVCIAMDKVGRRTVLAYS-----LFCSALACGV---VMVIPQKHYILGVVTAMVGkFAIGAAFGLI---YLYTAELYPTI 242
Cdd:cd17358  293 VATLLVDRLGRRPLLLVSaigmgIGLLALGLYFylqEHGALLSSVSWLPLVGLVI-YIISFSIGLGplpWVIMSEIFPAK 371

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767943787 243 VRSLAVGSGSMVCRLASILA----PFSVDLSSI----WIFipqlfvGTMALLSGVLTLK-LPETLGKRL 302
Cdd:cd17358  372 IKGLAGSLVTLVNWLFAFIVtktfPFLTLAWGAsgtfWIF------AGICGLALVFVLLfVPETKGKSL 434
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
 2-295 1.33e-08

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 55.97  E-value: 1.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787   2 EFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTW--WLYQMILSTVTVPF--ILCcwvlpetpFWLLSEGRYeeaqki 77
Cdd:cd17441  113 EFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTlgWRWLLILSALPLLIfaVLC--------FWLPESARY------ 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787  78 vdimakwnrasscklsellsldlqgpvsnsptevqkhnlsylfynwsitKRTLTVWLIWFTGSLGFY------------- 144
Cdd:cd17441  179 -------------------------------------------------WTTILLWFIWFSNAFSYYglvllttelfqag 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 145 -------------SFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALaCGVVMVIPQKHYI 211
Cdd:cd17441  210 dvcsgssgkkvegKCSLECEYLTTSDYMDLLWTTLSEFPGLLVTLWIIDRFGRKKTMALCFFVFSF-CTLLLFSCVGRFS 288

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 212 LgVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVD-LSSIWIFIPQLFVGTMALLSGVL 290
Cdd:cd17441  289 L-TVLLFIARAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMARVGALITPFIAQvMLESSVYLTLSVYSGCCLLAAIA 367


                 ....*
gi 767943787 291 TLKLP 295
Cdd:cd17441  368 SCFLP 372
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
 158-297 3.28e-08

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 54.80  E-value: 3.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 158 YLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAigAAFGLIYLYTAE 237
Cdd:cd17363  335 YLVSFLGSLSVLPGNIVSALLMDKIGRLKMIGGSMLLSAVCCFFLFFGNSESAMIGLQCLFCGVSI--AAWNALDVVTVE 412

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767943787 238 LYPTIVRSLAVGSGSMVCRLASILAPFSV-DLSSIWIFIPQLFVGTMALLSGVLTLKLPET 297
Cdd:cd17363  413 LYPTDKRATAFGFLNGLCKLAAILGNSIFgSFVGITKVIPILLASAALVCGGLLALKLPET 473
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 129-295 9.36e-08

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 52.97  E-value: 9.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 129 TLTVWLIWFTGSLGFY-------------SFSLNSVNLGGneylnlFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCS 195
Cdd:cd17365  173 TLLLWVTFFMGLLLVYllnswlpklmveaGYSLSQALTIT------LLLNIGGVIGSLLLGWLADRFGPKRVLALFFALG 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 196 ALACGVVMVIPQKHYILGVVTAMVGKFAIGAAfGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPF------SVDLS 269
Cdd:cd17365  247 AVSLALLGVSPASLVLLYVLVFLAGACVNGAQ-VGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLlgglllAAGLG 325

                        170       180
                 ....*....|....*....|....*.
gi 767943787 270 SIWIFipqLFVGTMALLSGVLTLKLP 295
Cdd:cd17365  326 PESVF---LALAIPAALGALAVLLLR 348
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
128-300 1.15e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 52.95  E-value: 1.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 128 RTLTVWLIWFTGSLGFYSFSLNSVNLGGNEY-LNLFLLGVVEIPAYTFVCIAM-------DKVGRRTVLAYSLFCSALAC 199
Cdd:COG2271  181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVRgLSLAQAGLLLSLPFLAGIVGSllggwlsDRLGRRRKLVLAIGLLLAAL 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 200 GVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAP----FSVDLSSIWIFI 275
Cdd:COG2271  261 ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPllvgYLLDATGYQAAF 340

                        170       180
                 ....*....|....*....|....*
gi 767943787 276 pqLFVGTMALLSGVLTLKLPETLGK 300
Cdd:COG2271  341 --LLLAALALLAALLALLLLRETRK 363
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 158-297 1.51e-07

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 52.62  E-value: 1.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 158 YLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGkfAIGAAFGLIYLYTAE 237
Cdd:cd17438  338 YLVSFLGSLSVLPGNIISALLMDKIGRIKMIGGSMLISAVCCFFLFFGNSESAMIGWQCLFCG--TSIAAWNALDVITVE 415

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767943787 238 LYPTIVRSLAVGSGSMVCRLASILA-PFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPET 297
Cdd:cd17438  416 LYPTNKRATAFGILNGLCKFAAILGnSIFASFVGITKVIPILLASTALVGGGLISLRLPET 476
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
 158-297 4.32e-06

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 48.10  E-value: 4.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 158 YLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVtAMVGKFAIgAAFGLIYLYTAE 237
Cdd:cd17439  339 YFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALL-CLFGGVSI-ASWNALDVLTVE 416

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767943787 238 LYPTIVRSLAVGSGSMVCRLASILApFSVDLSSIWIF--IPQLFVGTMALLSGVLTLKLPET 297
Cdd:cd17439  417 LYPSDKRTTAFGFLNALCKLAAVLG-ISIFTSFVGITkaVPILLASAALAAGSSLALKLPET 477
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
126-304 4.60e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 47.95  E-value: 4.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 126 TKRTLTVWLIWFTGSLGFYSFSLNSVNLggneYLNLFLLGVVEIPAYTFVCIAM------------DKVGRRTVLAYSLF 193
Cdd:COG2223  204 DPRFWLLSLLYFGTFGSFIGFSSWLPPY----LVDQFGLSAATAGLLAALFALLgalgrplggwlsDRIGGRRVLLIVFA 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 194 CSALACGVVMVIPQKHYILGVVTAMVGkFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWI 273
Cdd:COG2223  280 LMALGLLLLALALGSLWLFLVLFLLLG-LALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAT 358

                        170       180       190
                 ....*....|....*....|....*....|....
gi 767943787 274 FIPQ---LFVGTMALLSGVLTLKLPETLGKRLAT 304
Cdd:COG2223  359 GSYTaafLVFAVLALVALVLTLLLYRRPRRAAAA 392
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 2-266 5.65e-06

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 47.74  E-value: 5.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787    2 EFIGMKSRTWASVHLHSFFAVGTLLVA-LTGYLV-----RTWWLYQMILSTVTVPFILccWVLPETPFWLLSEgRYEEAQ 75
Cdd:TIGR00895 132 EYAPKRFRGTAVGLMFCGYPIGAAVGGfLAGWLIpvfgwRSLFYVGGIAPLLLLLLLM--RFLPESIDFLVSK-RPETVR 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787   76 KIVDIMAKWNRASScklseLLSLDLQGPVSNSPTEVQKhnlsyLFYNWSITKRTLTVWLIWFTGSLGFYSfsLNS----- 150
Cdd:TIGR00895 209 RIVNAIAPQMQAEA-----QSALPEQKSTQGTKRSVFK-----ALFQGKTARITVLLWLLYFMLLVGVYF--LTNwlpkl 276

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787  151 -VNLGGNEYLNLFLLGVVE---IPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMV--IPQKHYILGVVtamVGKFAI 224
Cdd:TIGR00895 277 mVELGFSLSLAATGGALFNfggVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGSTlfSPTLLLLLGAI---AGFFVN 353

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 767943787  225 GAAFGLiYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSV 266
Cdd:TIGR00895 354 GGQSGL-YALMALFYPTAIRATGVGWAIGIGRLGAIIGPILA 394
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
 158-297 8.20e-06

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 47.21  E-value: 8.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 158 YLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGkFAIgAAFGLIYLYTAE 237
Cdd:cd17440  340 YFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNG-LTI-SAWNSLDVVTVE 417

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767943787 238 LYPTIVRSLAVGSGSMVCRLASILAPFSV-DLSSIWIFIPQLFVGTMALLSGVLTLKLPET 297
Cdd:cd17440  418 LYPTDRRATGFGFLNALCKAAAVLGNLIFgSLVGITKAIPILLASTVLVCGGLVGLRLPDT 478
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
 134-297 1.68e-05

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 46.12  E-value: 1.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 134 LIWFTGSLGFYSFSLNS--------VNLGGNEYLNLF--------LLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSAL 197
Cdd:cd17364  203 GTWFLLDIAFYGQNLFQstiisaigFSKTMNAYQELFniavgqliIALAGTVPGYWFTVFLIDRIGRKKIQMMGFFGMTI 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 198 AcGVVMVIPQKHYILG--VVTAMVGKFAIGAAFG---LIYLYTAELYPTIVRSLAVGSGSMVCRLASILAP--FSVDLSS 270
Cdd:cd17364  283 F-LLILAGPYDHWKIStiGFFVLYGLTFFFSNFGpntTTFIVPAEVFPARVRSTCHGISAASGKIGAIVGSflFLSLTQN 361

                        170       180
                 ....*....|....*....|....*..
gi 767943787 271 IWIFIPQLFVGTMALLSGVLTLKLPET 297
Cdd:cd17364  362 IGVRNVLIILAGVALLGIILTLLFPEE 388
MFS_SLC22A31 cd17443
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...
 144-249 5.46e-05

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341001 [Multi-domain]  Cd Length: 343  Bit Score: 44.38  E-value: 5.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 144 YSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQ-KHYILGVVTAMVGKF 222
Cdd:cd17443  191 YCFARNLAPFVPTFYLPYFLQAGLEALACIFLCLTVDRCGRRGVLLLGTIVTGLSSLLLLALTQyLHGGLVLVLSVVGLL 270

                         90       100
                 ....*....|....*....|....*..
gi 767943787 223 AIGAAFGLIYLYTAELYPTIVRSLAVG 249
Cdd:cd17443  271 ASHAVSMLSMFFAAEVLPTVIRGAGLG 297
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
127-262 2.21e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 42.65  E-value: 2.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 127 KRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEY--------LNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALA 198
Cdd:COG2814  207 PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLglsasaagLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG 286

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767943787 199 CGVVMVIPqkHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILA 262
Cdd:COG2814  287 LLLLALAG--SLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 2-297 2.24e-04

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 42.67  E-value: 2.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787   2 EFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTW------WLYQMILStvTVPFILCCWV---LPETPFWLLSEGRYE 72
Cdd:cd17371  114 EYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLlppeiaWRVLFLLG--ALPALLVLFIrrfVKEPPQWQAARAARR 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787  73 EAQKIVDIMAKWNRASScKLSELLSLDLQGPvsnsptevqkhnlsyLFYNWSItkrtlTVWL---------IWFTGSLGF 143
Cdd:cd17371  192 HFADRPSLRELFSPPLL-RTTLLASLLATGA---------------LGGYYGI-----TTWLpsyltgergLSFEGSAGY 250

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 144 ysfsLNSVNLGGneYLNLFLLGVveipaytfvciAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFA 223
Cdd:cd17371  251 ----LVVTILGG--FLGYLAGGF-----------LADRIGRRNNFALFALGSAISILLYFFLPLSPTLILILGFPLGFFA 313

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767943787 224 IGaAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVD-LSSIWIFipQLFVGTMA----LLSGVLTLKLPET 297
Cdd:cd17371  314 SG-PFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGfLATSGSL--GTAIAVFAavyyIAGLVLALLLPET 389
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 145-292 3.41e-04

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 42.13  E-value: 3.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 145 SFSLNSVNLGGNEYLNLFLLG-VVEIPAYTFVCIAMDKVGRRTV-LAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKF 222
Cdd:cd17369  253 SYATQTLGVDRSTVLLAVLIAsVVAAITIPLFGWLSDRVGRRPVyLAGALLAALFAFPFFWLLDTGSTWLIVLAAVVVLG 332

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767943787 223 AI-GAAFGLIYLYTAELYPTIVRSLAVGSGSMvcrLASILAPFSVDLSSIWIFIPQ-------LFVGTMALLSGVLTL 292
Cdd:cd17369  333 VLhGMMYGPQAAFLAELFPTRVRYTGASLGYQ---LGAILGGGFAPLIATALVAATgswwpvaLYLAALAVISLVAAL 407
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
 120-302 5.50e-04

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 41.64  E-value: 5.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787  120 FYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNL-----------GGNEYLNLFLLGVVEI--------PAYTFVCIAMD 180
Cdd:TIGR00887 281 FFKWRHGKHLLGTAGSWFLLDIAFYGVNLNQKVIlsaigysppaaTNNAYEELYKTAVGNLiialagtvPGYWVTVFLVD 360

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787  181 KVGRRTV-LAYSLFCSALACgvVMVIPQKHYILGVVTAMVGKFAIGAAFG---LIYLYTAELYPTIVRSLAVGSGSMVCR 256
Cdd:TIGR00887 361 IIGRKPIqLMGFFILTVLFF--VLGFAYNHLSTHGFLAIYVLAQFFANFGpnaTTFIVPGEVFPTRYRSTAHGISAASGK 438

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767943787  257 LASILAPF----------SVDLSSIWIFIPQL---FVGTMaLLSGVLTLKLPETLGKRL 302
Cdd:TIGR00887 439 AGAIIGQFgflylaqhgdPTKGYPTGIWMGHVleiFALFM-FLGILFTLLIPETKGKSL 496
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 22-302 6.66e-04

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 41.40  E-value: 6.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787  22 VGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWvLPETPFWLLSEGRYEEAQKIV------DIMAKW-----NRASSC 90
Cdd:cd17433  141 IGIMGAYLAGLVLDWRWLAVLGSIPPTLMLLLMCF-MPETPRFLLTQHRRQEAMAALrflrgpDQGWEWecigiEQSFHL 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787  91 KLSELLSLDLQGPVSNSPTEVQkhnlsylfynwsitkrTLTVWLIWFTG--SLGFYSFSLNSVNLGGNEYLNLFLLGVVE 168
Cdd:cd17433  220 EEQSFSLALLKQPGIYKPLIIG----------------VSLMAFQQLTGinAVMFYAETIFEEAKFKDSSVASVIVAAIQ 283

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 169 IPAYTFVCIAMDKVGRRTVLAYSlfcsalacGVVMVIPQKHYILGVVTAMvGKFAIGAAFG---LIYLYTAELYPTIVRS 245
Cdd:cd17433  284 VLFTAVAALIMDRAGRKVLLVLS--------GVVMVFSTAAFGWLAVGSM-GFFIAGFAVGwgpIPWLVMSEIFPLHVRG 354

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767943787 246 LAVGsgsmVCRLASILAPFSVD---------LSSIWIFipQLFVGTMALLSGVLTLKLPETLGKRL 302
Cdd:cd17433  355 VASG----ICVLTNWLMAFLVTkefsslmevLSSYGTF--WLFSAFCAFSVLFTLFCVPETKGKTL 414
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 162-296 1.66e-03

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 39.86  E-value: 1.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 162 FLLGVVEIPAyTFVCI-AMDKVGRRTVLAYSLFCSALACGV----VMVIPQKHYILGVVTAMVGKFAIGAAFGL---IYL 233
Cdd:cd17315  221 IIVGVVNLLA-TLVAIrLVDKVGRRPLLLIGFAGMAASLLLlaiaFLLPALAKAAGWLALLGILLYIAAFAMGAgpvPWL 299

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767943787 234 YTAELYPTIVRSLAVGSGSMVCRLASIL--APFSVDLSSIWIFIPQLFVGTMALLSGVLT-LKLPE 296
Cdd:cd17315  300 LLSEIFPLRIRGKGMAIATLVNWIFNFIvgLTFLIMVSTIGLAGVFIFFAAVCLLALVFVfFFVPE 365
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 163-303 2.31e-03

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 39.64  E-value: 2.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 163 LLGVVEIpayTFVCIAM---DKVGRRTVL-------AYSLFCSALACGVVMVIPQKHYILGVVTAM--VGKFAIGaaFGL 230
Cdd:cd17362  236 GLGVFKL---LMTIVAVllvDKLGRRPLLlggvsgmVVSLFLLAAYNLFVQMGPAGLAWLSLVALLlyVGAYQIS--FGP 310

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767943787 231 I-YLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFV--GTMALLS-GVLTLKLPETLGKRLA 303
Cdd:cd17362  311 IsWLMVSEIFPLRVRGRAIALAVLVNFGSNALVSLAFLPLQELIGLPGTFLgfGVIGVLAlLFIYFTVPETKGLSLE 387
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
 173-302 3.15e-03

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 38.92  E-value: 3.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 173 TFVCIA---MDKVGRRTVL-------AYSLFCSALACGVVMVIPQK---HYILGVVTAM--VGKFAIGaaFGLI-YLYTA 236
Cdd:cd17437  238 LFILVAtflLDKVGRRPLLltstggmTLSLTALATSLTFIDRNGGGltwALVLAITAVCsfVAFFSIG--AGPItWVYSS 315

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767943787 237 ELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPqlfvGTMALLSGVLTLK-------LPETLGKRL 302
Cdd:cd17437  316 EIFPLRLRAQGASLGVVVNRLMSGTVSMTFLSMSKAITTG----GTFFLFAGVAAAAwvffyffLPETKGKSL 384
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 127-292 5.92e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 38.18  E-value: 5.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 127 KRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEY--------LNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALA 198
Cdd:cd06174  203 PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGglsvavagLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMAL 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 199 CGVVMVIPQKHYILGVVTAMVGkFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQL 278
Cdd:cd06174  283 GLALLLLAPSLLLLLLLLLLLG-FGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTG 361

                        170
                 ....*....|....
gi 767943787 279 FVGTMALLSGVLTL 292
Cdd:cd06174  362 AFLVLAVLLLLAAI 375
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
130-312 7.88e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 37.65  E-value: 7.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 130 LTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVeIPAYTFVCIAM--------DKVGRRTVLAYSLFCSALACGV 201
Cdd:COG2814   13 LALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLV-VTAYLLGAALGaplagrlaDRFGRRRVLLLGLLLFALGSLL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943787 202 VMVIPQkHYILGVVTAMVGkFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPF-----SVDLSSIWIFIp 276
Cdd:COG2814   92 CALAPS-LWLLLAARFLQG-LGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLlggllADLFGWRWVFL- 168

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 767943787 277 qLFVGTMALLSGVLTLKLPETLGKRLATTWEEAAKL 312
Cdd:COG2814  169 -VNAVLALLALLLLLRLLPESRPAARARLRGSLREL 203
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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