NCBI Conserved Domain Search

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.

Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 47.33 E-value: 1.54e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981801 107 TSSQHYILSGSDDFNLYMWRIPAdpeaggigrvvNGAFMVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWSPyKQPGC 186
Cdd:cd00200  102 SPDGRILSSSSRDKTIKVWDVET-----------GKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL-RTGKC 169

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767981801 187 TGDLDGRiEDDSRCLYTHEEYISLVLNSGSG 217
Cdd:cd00200  170 VATLTGH-TGEVNSVAFSPDGEKLLSSSSDG 199

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.

Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 46.56 E-value: 2.66e-05

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767981801 108 SSQHYILSGSDDFNLYMWripaDPEAGGIGRVvngafmvLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWS 179
Cdd:cd00200   61 ADGTYLASGSSDKTIRLW----DLETGECVRT-------LTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD 121

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.

Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 46.17 E-value: 3.64e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981801 113 ILSGSDDFNLYMWRIPAdpeaggiGRVVngafMVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWspykqpgctgdlDG 192
Cdd:cd00200  192 LLSSSSDGTIKLWDLST-------GKCL----GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW------------DL 248

                         90       100       110
                 ....*....|....*....|....*....|....
gi 767981801 193 RIEDDSRCLYTHEEYISLVLNSGSGL-----SHD 221
Cdd:cd00200  249 RTGECVQTLSGHTNSVTSLAWSPDGKrlasgSAD 282

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.

Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 40.37 E-value: 8.33e-05

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 767981801   145 MVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWS 179
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40

coronin; Provisional

Pssm-ID: 240412 [Multi-domain] Cd Length: 568 Bit Score: 44.94 E-value: 1.65e-04

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767981801 115 SGSDDFNLYMWRIPADPEAGgigRVVNGAFMVLKGHRSIVNQVRFNPHTYMI-CSSGVEKIIKIW 178
Cdd:PTZ00420  92 SGSEDLTIRVWEIPHNDESV---KEIKDPQCILKGHKKKISIIDWNPMNYYImCSSGFDSFVNIW 153

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.

Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 43.48 E-value: 3.00e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981801 109 SQHYILSGSDDFNLYMWRIpadpeagGIGRVVngafMVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWSPYKQPgCTG 188
Cdd:cd00200  146 DGTFVASSSQDGTIKLWDL-------RTGKCV----ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK-CLG 213


                 ....
gi 767981801 189 DLDG 192
Cdd:cd00200  214 TLRG 217

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.

Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 43.48 E-value: 3.22e-04

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767981801 108 SSQHYILSGSDDFNLYMWRIpadpeagGIGRVVngafMVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWS 179
Cdd:cd00200  229 PDGYLLASGSEDGTIRVWDL-------RTGECV----QTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289

WD domain, G-beta repeat;

Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 37.71 E-value: 7.57e-04

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767981801  145 MVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWS 179
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.

Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 41.17 E-value: 1.88e-03

                         10        20        30
                 ....*....|....*....|....*....|....
gi 767981801 146 VLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWS 179
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWD 37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.

Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 40.78 E-value: 2.45e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981801 107 TSSQHYILSGSDDFNLYMWRIPadpeaggigrvVNGAFMVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWSpYKQPGC 186
Cdd:cd00200   18 SPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD-LETGEC 85

                         90       100
                 ....*....|....*....|...
gi 767981801 187 TGDLDGrieddsrclytHEEYIS 209
Cdd:cd00200   86 VRTLTG-----------HTSYVS 97