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Conserved domains on  [gi|767937795|ref|XP_011535965|]
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transmembrane and coiled-coil domain-containing protein 6 isoform X4 [Homo sapiens]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 1000979)

armadillo/beta-catenin-like repeat-containing protein similar to Saccharomyces cerevisiae vacuolar protein 8 that functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP1 super family cl34886
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
23-399 3.48e-09

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5064:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 58.36  E-value: 3.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937795  23 RREREAALRKARREQQLVSKRLLRnDAPEEAGEGCVAAILGETEVQQFLRQAQRGTEEKEREGALVSLRRGLQ---HPET 99
Cdd:COG5064   29 REEQQVELRKQKREELLNKRRNLA-DVSEEAESSFIPMEQQFYSELPQLTQQLFSDDIEQQLQAVYKFRKLLSketSPPI 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937795 100 QQTFIrlEGSMRTLVGLLTSNQA-LLQLEAARCLHELSH--SEQSTVAEAClPATSYLLTYLSSHSSDFIELCLYTLGNL 176
Cdd:COG5064  108 QPVID--AGVVPRFVEFMDEIQRdMLQFEAAWALTNIASgtTQQTKVVVDA-GAVPLFIQLLSSTEDDVREQAVWALGNI 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937795 177 IVESEAVRRQLLPQGIVPALAACIQS--PHVAVLEALGYALSQLLQAEEApekiiPPASASSSILASTLPQHMLQMlqpg 254
Cdd:COG5064  185 AGDSEGCRDYVLQCGALEPLLGLLLSsaIHISMLRNATWTLSNLCRGKNP-----PPDWSNISQALPILAKLIYSR---- 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937795 255 pklNPGVAVEFAWCLHYIicSQVSNpllighgalstlglllldlaGAVQKTEDAG-----LELLA-------CPVLRCLS 322
Cdd:COG5064  256 ---DPEVLVDACWAISYL--SDGPN--------------------EKIQAVLDVGipgrlVELLShesakiqTPALRSVG 310

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767937795 323 NLLTEAAVETvggQMQLRdervVAALFILLQFFFQKQPSLLPEGLWLLNNLTANSPSFCTSLLSLDLIEPLLQLLPV 399
Cdd:COG5064  311 NIVTGSDDQT---QVIIN----CGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSS 380
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
23-399 3.48e-09

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 58.36  E-value: 3.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937795  23 RREREAALRKARREQQLVSKRLLRnDAPEEAGEGCVAAILGETEVQQFLRQAQRGTEEKEREGALVSLRRGLQ---HPET 99
Cdd:COG5064   29 REEQQVELRKQKREELLNKRRNLA-DVSEEAESSFIPMEQQFYSELPQLTQQLFSDDIEQQLQAVYKFRKLLSketSPPI 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937795 100 QQTFIrlEGSMRTLVGLLTSNQA-LLQLEAARCLHELSH--SEQSTVAEAClPATSYLLTYLSSHSSDFIELCLYTLGNL 176
Cdd:COG5064  108 QPVID--AGVVPRFVEFMDEIQRdMLQFEAAWALTNIASgtTQQTKVVVDA-GAVPLFIQLLSSTEDDVREQAVWALGNI 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937795 177 IVESEAVRRQLLPQGIVPALAACIQS--PHVAVLEALGYALSQLLQAEEApekiiPPASASSSILASTLPQHMLQMlqpg 254
Cdd:COG5064  185 AGDSEGCRDYVLQCGALEPLLGLLLSsaIHISMLRNATWTLSNLCRGKNP-----PPDWSNISQALPILAKLIYSR---- 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937795 255 pklNPGVAVEFAWCLHYIicSQVSNpllighgalstlglllldlaGAVQKTEDAG-----LELLA-------CPVLRCLS 322
Cdd:COG5064  256 ---DPEVLVDACWAISYL--SDGPN--------------------EKIQAVLDVGipgrlVELLShesakiqTPALRSVG 310

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767937795 323 NLLTEAAVETvggQMQLRdervVAALFILLQFFFQKQPSLLPEGLWLLNNLTANSPSFCTSLLSLDLIEPLLQLLPV 399
Cdd:COG5064  311 NIVTGSDDQT---QVIIN----CGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSS 380
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
23-399 3.48e-09

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 58.36  E-value: 3.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937795  23 RREREAALRKARREQQLVSKRLLRnDAPEEAGEGCVAAILGETEVQQFLRQAQRGTEEKEREGALVSLRRGLQ---HPET 99
Cdd:COG5064   29 REEQQVELRKQKREELLNKRRNLA-DVSEEAESSFIPMEQQFYSELPQLTQQLFSDDIEQQLQAVYKFRKLLSketSPPI 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937795 100 QQTFIrlEGSMRTLVGLLTSNQA-LLQLEAARCLHELSH--SEQSTVAEAClPATSYLLTYLSSHSSDFIELCLYTLGNL 176
Cdd:COG5064  108 QPVID--AGVVPRFVEFMDEIQRdMLQFEAAWALTNIASgtTQQTKVVVDA-GAVPLFIQLLSSTEDDVREQAVWALGNI 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937795 177 IVESEAVRRQLLPQGIVPALAACIQS--PHVAVLEALGYALSQLLQAEEApekiiPPASASSSILASTLPQHMLQMlqpg 254
Cdd:COG5064  185 AGDSEGCRDYVLQCGALEPLLGLLLSsaIHISMLRNATWTLSNLCRGKNP-----PPDWSNISQALPILAKLIYSR---- 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937795 255 pklNPGVAVEFAWCLHYIicSQVSNpllighgalstlglllldlaGAVQKTEDAG-----LELLA-------CPVLRCLS 322
Cdd:COG5064  256 ---DPEVLVDACWAISYL--SDGPN--------------------EKIQAVLDVGipgrlVELLShesakiqTPALRSVG 310

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767937795 323 NLLTEAAVETvggQMQLRdervVAALFILLQFFFQKQPSLLPEGLWLLNNLTANSPSFCTSLLSLDLIEPLLQLLPV 399
Cdd:COG5064  311 NIVTGSDDQT---QVIIN----CGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSS 380
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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