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Conserved domains on  [gi|767973889|ref|XP_011536507|]
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adhesion G-protein coupled receptor D1 isoform X2 [Homo sapiens]

Protein Classification

GPS and 7tm_GPCRs domain-containing protein( domain architecture ID 11716454)

protein containing domains LamG, GPS, and 7tm_GPCRs

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
535-794 6.23e-173

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd15256:

Pssm-ID: 475119 [Multi-domain]  Cd Length: 260  Bit Score: 499.45  E-value: 6.23e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 535 QVALSSISYVGCSLSVLCLVATLVTFAVLSSVSTIRNQRYHIHANLSFAVLVAQVLLLISFRLEPGTTPCQVMAVLLHYF 614
Cdd:cd15256    1 QVALSSITYVGCSLSIFCLAITLVTFAVLSSVSTIRNQRYHIHANLSFAVLVAQILLLISFRFEPGTLPCKIMAILLHFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 615 FLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLICIISLSFAMDSYGTSNNCWLSLASGAIWAFVAPALF 694
Cdd:cd15256   81 FLSAFAWMLVEGLHLYSMVIKVFGSEESKHFYYYGIGWGSPLLICIISLTSALDSYGESDNCWLSLENGAIWAFVAPALF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 695 VIVVNIGILIAVTRVISQISADNYKIHGDPSAFKLTAKAVAVLLPILGTSWVFGVLAVNGCAVVFQYMFATLNSLQGLFI 774
Cdd:cd15256  161 VIVVNIGILIAVTRVISRISADNYKVHGDANAFKLTAKAVAVLLPILGSSWVFGVLAVNTHALVFQYMFAIFNSLQGFFI 240
                        250       260
                 ....*....|....*....|
gi 767973889 775 FLFHCLLNSEVRAAFKHKTK 794
Cdd:cd15256  241 FLFHCLLNSEVRAAFKHKTK 260
GPS pfam01825
GPCR proteolysis site, GPS, motif; The GPS motif is found in GPCRs, and is the site for ...
482-522 1.04e-11

GPCR proteolysis site, GPS, motif; The GPS motif is found in GPCRs, and is the site for auto-proteolysis, so is thus named, GPS. The GPS motif is a conserved sequence of ~40 amino acids containing canonical cysteine and tryptophan residues, and is the most highly conserved part of the domain. In most, if not all, cell-adhesion GPCRs these undergo autoproteolysis in the GPS between a conserved aliphatic residue (usually a leucine) and a threonine, serine, or cysteine residue. In higher eukaryotes this motif is found embedded in the C-terminal beta-stranded part of a GAIN domain - GPCR-Autoproteolysis INducing (GAIN). The GAIN-GPS domain adopts a fold in which the GPS motif, at the C-terminus, forms five beta-strands that are tightly integrated into the overall GAIN domain. The GPS motif, evolutionarily conserved from tetrahymena to mammals, is the only extracellular domain shared by all human cell-adhesion GPCRs and PKD proteins, and is the locus of multiple human disease mutations. The GAIN-GPS domain is both necessary and sufficient functionally for autoproteolysis, suggesting an autoproteolytic mechanism whereby the overall GAIN domain fine-tunes the chemical environment in the GPS to catalyze peptide bond hydrolysis. In the cell-adhesion GPCRs and PKD proteins, the GPS motif is always located at the end of their long N-terminal extracellular regions, immediately before the first transmembrane helix of the respective protein.


:

Pssm-ID: 460350  Cd Length: 44  Bit Score: 60.01  E-value: 1.04e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 767973889  482 CAFLDFS-SGEGVWSNHGCALTRGNLTYSVCRCTHLTNFAIL 522
Cdd:pfam01825   3 CVFWDFTnSTTGRWSTEGCTTVSLNDTHTVCSCNHLTSFAVL 44
Laminin_G_3 super family cl48183
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
139-213 6.37e-11

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


The actual alignment was detected with superfamily member pfam13385:

Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 61.25  E-value: 6.37e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767973889  139 WTHVLFTWkSKEGLKVYVNGTL--STSDPSGKVSRDYGesnvNLVIGSEQDqAKCYENGAFDEFIIWERALTPDEIA 213
Cdd:pfam13385  81 WTHVAVTY-DGGTLRLYVNGVLvgSSTLTGGPPPGTGG----PLYIGRSPG-GDDYFNGLIDEVRIYDRALSAAEIA 151
 
Name Accession Description Interval E-value
7tmB2_GPR133 cd15256
orphan adhesion receptor GPR133, member of the class B2 family of seven-transmembrane G ...
535-794 6.23e-173

orphan adhesion receptor GPR133, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR133 is an orphan receptor that belongs to the group V adhesion-GPCRs together with GPR144. The function of GPR144 has not yet been characterized, whereas GPR133 is highly expressed in the pituitary gland and is coupled to the Gs protein, leading to activation of adenylyl cyclase pathway. Moreover, genetic variations in the GPR133 have been reported to be associated with adult height and heart rate. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in ligand recognition as well as cell-cell adhesion and cell-matrix interactions, linked by a stalk region to a class B seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. However, several adhesion GPCRs, including GPR 111, GPR115, and CELSR1, are predicted to be non-cleavable at the GAIN domain because of the lack of a consensus catalytic triad sequence (His-Leu-Ser/Thr) within their GPS.


Pssm-ID: 320384 [Multi-domain]  Cd Length: 260  Bit Score: 499.45  E-value: 6.23e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 535 QVALSSISYVGCSLSVLCLVATLVTFAVLSSVSTIRNQRYHIHANLSFAVLVAQVLLLISFRLEPGTTPCQVMAVLLHYF 614
Cdd:cd15256    1 QVALSSITYVGCSLSIFCLAITLVTFAVLSSVSTIRNQRYHIHANLSFAVLVAQILLLISFRFEPGTLPCKIMAILLHFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 615 FLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLICIISLSFAMDSYGTSNNCWLSLASGAIWAFVAPALF 694
Cdd:cd15256   81 FLSAFAWMLVEGLHLYSMVIKVFGSEESKHFYYYGIGWGSPLLICIISLTSALDSYGESDNCWLSLENGAIWAFVAPALF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 695 VIVVNIGILIAVTRVISQISADNYKIHGDPSAFKLTAKAVAVLLPILGTSWVFGVLAVNGCAVVFQYMFATLNSLQGLFI 774
Cdd:cd15256  161 VIVVNIGILIAVTRVISRISADNYKVHGDANAFKLTAKAVAVLLPILGSSWVFGVLAVNTHALVFQYMFAIFNSLQGFFI 240
                        250       260
                 ....*....|....*....|
gi 767973889 775 FLFHCLLNSEVRAAFKHKTK 794
Cdd:cd15256  241 FLFHCLLNSEVRAAFKHKTK 260
7tm_2 pfam00002
7 transmembrane receptor (Secretin family); This family is known as Family B, the ...
538-774 2.96e-63

7 transmembrane receptor (Secretin family); This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs). They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteriztic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.


Pssm-ID: 459625 [Multi-domain]  Cd Length: 248  Bit Score: 212.91  E-value: 2.96e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889  538 LSSISYVGCSLSVLCLvatLVTFAVLSSVSTIRNQRYHIHANLSFAVLVAQVLLLISFRLEPGTTP--------CQVMAV 609
Cdd:pfam00002   4 LKVIYTVGYSLSLVAL---LLAIAIFLLFRKLHCTRNYIHLNLFASFILRALLFLVGDAVLFNKQDldhcswvgCKVVAV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889  610 LLHYFFLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLICIISLSFAMDSYGTSNNCWLSLASGAIWAFV 689
Cdd:pfam00002  81 FLHYFFLANFFWMLVEGLYLYTLLVEVFFSERKYFWWYLLIGWGVPALVVGIWAGVDPKGYGEDDGCWLSNENGLWWIIR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889  690 APALFVIVVNIGILIAVTRVISQISADNYKIHGDPSAFKLTAKAVAVLLPILGTSWVFGVLAVN---GCAVVFQYMFATL 766
Cdd:pfam00002 161 GPILLIILVNFIIFINIVRILVQKLRETNMGKSDLKQYRRLAKSTLLLLPLLGITWVFGLFAFNpenTLRVVFLYLFLIL 240

                  ....*...
gi 767973889  767 NSLQGLFI 774
Cdd:pfam00002 241 NSFQGFFV 248
GPS pfam01825
GPCR proteolysis site, GPS, motif; The GPS motif is found in GPCRs, and is the site for ...
482-522 1.04e-11

GPCR proteolysis site, GPS, motif; The GPS motif is found in GPCRs, and is the site for auto-proteolysis, so is thus named, GPS. The GPS motif is a conserved sequence of ~40 amino acids containing canonical cysteine and tryptophan residues, and is the most highly conserved part of the domain. In most, if not all, cell-adhesion GPCRs these undergo autoproteolysis in the GPS between a conserved aliphatic residue (usually a leucine) and a threonine, serine, or cysteine residue. In higher eukaryotes this motif is found embedded in the C-terminal beta-stranded part of a GAIN domain - GPCR-Autoproteolysis INducing (GAIN). The GAIN-GPS domain adopts a fold in which the GPS motif, at the C-terminus, forms five beta-strands that are tightly integrated into the overall GAIN domain. The GPS motif, evolutionarily conserved from tetrahymena to mammals, is the only extracellular domain shared by all human cell-adhesion GPCRs and PKD proteins, and is the locus of multiple human disease mutations. The GAIN-GPS domain is both necessary and sufficient functionally for autoproteolysis, suggesting an autoproteolytic mechanism whereby the overall GAIN domain fine-tunes the chemical environment in the GPS to catalyze peptide bond hydrolysis. In the cell-adhesion GPCRs and PKD proteins, the GPS motif is always located at the end of their long N-terminal extracellular regions, immediately before the first transmembrane helix of the respective protein.


Pssm-ID: 460350  Cd Length: 44  Bit Score: 60.01  E-value: 1.04e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 767973889  482 CAFLDFS-SGEGVWSNHGCALTRGNLTYSVCRCTHLTNFAIL 522
Cdd:pfam01825   3 CVFWDFTnSTTGRWSTEGCTTVSLNDTHTVCSCNHLTSFAVL 44
GPS smart00303
G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin ...
480-527 1.91e-11

G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin REJ and polycystin.


Pssm-ID: 197639  Cd Length: 49  Bit Score: 59.71  E-value: 1.91e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 767973889   480 VYCAFldFSSGEGVWSNHGCALTRGNLTYSVCRCTHLTNFAILMQVVP 527
Cdd:smart00303   3 PICVF--WDESSGEWSTRGCELLETNGTHTTCSCNHLTTFAVLMDVPP 48
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
139-213 6.37e-11

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 61.25  E-value: 6.37e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767973889  139 WTHVLFTWkSKEGLKVYVNGTL--STSDPSGKVSRDYGesnvNLVIGSEQDqAKCYENGAFDEFIIWERALTPDEIA 213
Cdd:pfam13385  81 WTHVAVTY-DGGTLRLYVNGVLvgSSTLTGGPPPGTGG----PLYIGRSPG-GDDYFNGLIDEVRIYDRALSAAEIA 151
PTX cd00152
Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their ...
114-216 4.43e-06

Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated in innate immunity. CRP binds to ligands containing phosphocholine, SAP binds to amyloid fibrils, DNA, chromatin, fibronectin, C4-binding proteins and glycosaminoglycans. "Long" pentraxins have N-terminal extensions to the common pentraxin domain; one group, the neuronal pentraxins, may be involved in synapse formation and remodeling, and they may also be able to form heteromultimers.


Pssm-ID: 238086  Cd Length: 201  Bit Score: 48.42  E-value: 4.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 114 TLLYYGRYNSSC---ISKPEQ---CGPEGPYWTHVLFTWKSKEGL-KVYVNGTLStsdPSGKVSRDY--GESNVnLVIGS 184
Cdd:cd00152   61 ELLLYKEKDGGYslyIGGKEVtfkVPESDGAWHHICVTWESTSGIaELWVNGKLS---VRKSLKKGYtvGPGGS-IILGQ 136
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 767973889 185 EQDQAkcyeNGAFDE----------FIIWERALTPDEIAMYF 216
Cdd:cd00152  137 EQDSY----GGGFDAtqsfvgeisdVNMWDSVLSPEEIKNVY 174
PTX smart00159
Pentraxin / C-reactive protein / pentaxin family; This family form a doscoid pentameric ...
139-219 1.45e-05

Pentraxin / C-reactive protein / pentaxin family; This family form a doscoid pentameric structure. Human serum amyloid P demonstrates calcium-mediated ligand-binding.


Pssm-ID: 128463  Cd Length: 206  Bit Score: 46.88  E-value: 1.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889   139 WTHVLFTWKSKEGL-KVYVNGTLSTsdpsGKVS-RDYG-ESNVNLVIGSEQDqakCYeNGAFD----------EFIIWER 205
Cdd:smart00159  92 WHHICTTWESSSGIaELWVDGKPGV----RKGLaKGYTvKPGGSIILGQEQD---SY-GGGFDatqsfvgeigDLNMWDS 163
                           90
                   ....*....|....
gi 767973889   206 ALTPDEIAMYFTAA 219
Cdd:smart00159 164 VLSPEEIKSVYKGS 177
 
Name Accession Description Interval E-value
7tmB2_GPR133 cd15256
orphan adhesion receptor GPR133, member of the class B2 family of seven-transmembrane G ...
535-794 6.23e-173

orphan adhesion receptor GPR133, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR133 is an orphan receptor that belongs to the group V adhesion-GPCRs together with GPR144. The function of GPR144 has not yet been characterized, whereas GPR133 is highly expressed in the pituitary gland and is coupled to the Gs protein, leading to activation of adenylyl cyclase pathway. Moreover, genetic variations in the GPR133 have been reported to be associated with adult height and heart rate. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in ligand recognition as well as cell-cell adhesion and cell-matrix interactions, linked by a stalk region to a class B seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. However, several adhesion GPCRs, including GPR 111, GPR115, and CELSR1, are predicted to be non-cleavable at the GAIN domain because of the lack of a consensus catalytic triad sequence (His-Leu-Ser/Thr) within their GPS.


Pssm-ID: 320384 [Multi-domain]  Cd Length: 260  Bit Score: 499.45  E-value: 6.23e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 535 QVALSSISYVGCSLSVLCLVATLVTFAVLSSVSTIRNQRYHIHANLSFAVLVAQVLLLISFRLEPGTTPCQVMAVLLHYF 614
Cdd:cd15256    1 QVALSSITYVGCSLSIFCLAITLVTFAVLSSVSTIRNQRYHIHANLSFAVLVAQILLLISFRFEPGTLPCKIMAILLHFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 615 FLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLICIISLSFAMDSYGTSNNCWLSLASGAIWAFVAPALF 694
Cdd:cd15256   81 FLSAFAWMLVEGLHLYSMVIKVFGSEESKHFYYYGIGWGSPLLICIISLTSALDSYGESDNCWLSLENGAIWAFVAPALF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 695 VIVVNIGILIAVTRVISQISADNYKIHGDPSAFKLTAKAVAVLLPILGTSWVFGVLAVNGCAVVFQYMFATLNSLQGLFI 774
Cdd:cd15256  161 VIVVNIGILIAVTRVISRISADNYKVHGDANAFKLTAKAVAVLLPILGSSWVFGVLAVNTHALVFQYMFAIFNSLQGFFI 240
                        250       260
                 ....*....|....*....|
gi 767973889 775 FLFHCLLNSEVRAAFKHKTK 794
Cdd:cd15256  241 FLFHCLLNSEVRAAFKHKTK 260
7tmB2_GPR133-like_Adhesion_V cd15933
orphan GPR133 and related proteins, group V adhesion GPCRs, member of class B2 family of ...
535-789 2.39e-126

orphan GPR133 and related proteins, group V adhesion GPCRs, member of class B2 family of seven-transmembrane G protein-coupled receptors; group V adhesion GPCRs include orphan receptors GPR133, GPR144, and closely related proteins. The function of GPR144 has not yet been characterized, whereas GPR133 is highly expressed in the pituitary gland and is coupled to the G(s) protein, leading to activation of adenylate cyclase pathway. Moreover, genetic variations in the GPR133 have been reported to be associated with adult height and heart rate. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in ligand recognition as well as cell-cell adhesion and cell-matrix interactions, linked by a stalk region to a class B seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. However, several adhesion GPCRs, including GPR 111, GPR115, and CELSR1, are predicted to be non-cleavable at the GAIN domain because of the lack of a consensus catalytic triad sequence (His-Leu-Ser/Thr) within their GPS.


Pssm-ID: 320599 [Multi-domain]  Cd Length: 252  Bit Score: 379.36  E-value: 2.39e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 535 QVALSSISYVGCSLSVLCLVATLVTFAVLSSVSTirnQRYHIHANLSFAVLVAQVLLLISFRLEPGTTPCQVMAVLLHYF 614
Cdd:cd15933    1 ERALSIISYIGCGISIACLALTLIIFLVLRVLSS---DRFQIHKNLCVALLLAQILLLAGEWAEGNKVACKVVAILLHFF 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 615 FLSAFAWMLVEGLHLYSMVIKVFgSEDSKHRYYYGMGWGFPLLICIISLSFAMDSYGTSNNCWLSLASGAIWAFVAPALF 694
Cdd:cd15933   78 FMAAFSWMLVEGLHLYLMIVKVF-NYKSKMRYYYFIGWGLPAIIVAISLAILFDDYGSPNVCWLSLDDGLIWAFVGPVIF 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 695 VIVVNIGILIAVTRVISQISADNYKIH-GDPSAFKLTAKAVAVLLPILGTSWVFGVLAVNGCAVVFQYMFATLNSLQGLF 773
Cdd:cd15933  157 IITVNTVILILVVKITVSLSTNDAKKSqGTLAQIKSTAKASVVLLPILGLTWLFGVLVVNSQTIVFQYIFVILNSLQGLM 236
                        250
                 ....*....|....*.
gi 767973889 774 IFLFHCLLNSEVRAAF 789
Cdd:cd15933  237 IFLFHCVLNSEVRSAF 252
7tmB2_Adhesion cd15040
adhesion receptors, subfamily B2 of the class B family of seven-transmembrane G ...
535-789 1.49e-85

adhesion receptors, subfamily B2 of the class B family of seven-transmembrane G protein-coupled receptors; The B2 subfamily of class B GPCRs consists of cell-adhesion receptors with 33 members in humans and vertebrates. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing a variety of structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, linked to a class B seven-transmembrane domain. These include, for example, EGF (epidermal growth factor)-like domains in CD97, Celsr1 (cadherin family member), Celsr2, Celsr3, EMR1 (EGF-module-containing mucin-like hormone receptor-like 1), EMR2, EMR3, and Flamingo; two laminin A G-type repeats and nine cadherin domains in Flamingo and its human orthologs Celsr1, Celsr2 and Celsr3; olfactomedin-like domains in the latrotoxin receptors; and five or four thrombospondin type 1 repeats in BAI1 (brain-specific angiogenesis inhibitor 1), BAI2 and BAI3. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320168 [Multi-domain]  Cd Length: 253  Bit Score: 272.91  E-value: 1.49e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 535 QVALSSISYVGCSLSVLCLVATLVTFAVLSSvsTIRNQRYHIHANLSFAVLVAQVLLLISFRLEPGTTPCQVMAVLLHYF 614
Cdd:cd15040    1 EKALSIITYIGCGLSLLGLLLTIITYILFRK--LRKRKPTKILLNLCLALLLANLLFLFGINSTDNPVLCTAVAALLHYF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 615 FLSAFAWMLVEGLHLYSMVIKVFGSEDSK-HRYYYGMGWGFPLLICIISLSFAMDSYGTSNN-CWLSLASGAIWAFVAPA 692
Cdd:cd15040   79 LLASFMWMLVEALLLYLRLVKVFGTYPRHfILKYALIGWGLPLIIVIITLAVDPDSYGNSSGyCWLSNGNGLYYAFLGPV 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 693 LFVIVVNIGILIAVTRVISQISADNykIHGDPSAFKLTAKAVAVLLPILGTSWVFGVLAVNGCAVVFQYMFATLNSLQGL 772
Cdd:cd15040  159 LLIILVNLVIFVLVLRKLLRLSAKR--NKKKRKKTKAQLRAAVSLFFLLGLTWIFGILAIFGARVVFQYLFAIFNSLQGF 236
                        250
                 ....*....|....*..
gi 767973889 773 FIFLFHCLLNSEVRAAF 789
Cdd:cd15040  237 FIFIFHCLRNKEVRKAW 253
7tmB2_latrophilin-like_invertebrate cd15440
invertebrate latrophilin-like receptors, member of the class B2 family of seven-transmembrane ...
535-786 1.13e-80

invertebrate latrophilin-like receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors; This subgroup includes latrophilin-like proteins that are found in invertebrates such as insects and worms. Latrophilins (also called lectomedins or latrotoxin receptors) belong to Group I adhesion GPCRs, which also include ETL (EGF-TM7-latrophilin-related protein). These receptors are a member of the adhesion family (subclass B2) that belongs to the class B GPCRs. Three subtypes of vertebrate latrophilins have been identified: LPH1 (latrophilin-1), LPH2, and LPH3. The latrophilin-1 is a brain-specific calcium-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. Latrophilin-2 and -3, although sharing strong sequence homology to latrophilin-1, do not bind alpha-latrotoxin. While latrophilin-3 is also brain specific, latrophilin-2 is ubiquitously distributed. The endogenous ligands for these two receptors are unknown. ETL, a seven transmembrane receptor containing EGF-like repeats is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. The function of the ETL is unknown. All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320556 [Multi-domain]  Cd Length: 259  Bit Score: 260.27  E-value: 1.13e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 535 QVALSSISYVGCSLSVLCLVATLVTFAVlssVSTIRNQRYHIHANLSFAVLVAQVLLLISFRLEPGTTPCQVMAVLLHYF 614
Cdd:cd15440    1 QSALTFITYIGCIISIVCLLLAFITFTC---FRNLQCDRNTIHKNLCLCLLIAEIVFLLGIDQTENRTLCGVIAGLLHYF 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 615 FLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLICIISLSFAMDSYGTSNNCWLSLASGAIWAFVAPALF 694
Cdd:cd15440   78 FLAAFSWMLLEGFQLYVMLVEVFEPEKSRIKWYYLFGYGLPALIVAVSAGVDPTGYGTEDHCWLSTENGFIWSFVGPVIV 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 695 VIVVNIGIL-IAVTRVISQISAD-NYKIHGDPSAFKLTAKAVAVLLPILGTSWVFGVLAVNGCAVVFQYMFATLNSLQGL 772
Cdd:cd15440  158 VLLANLVFLgMAIYVMCRHSSRSaSKKDASKLKNIRGWLKGSIVLVVLLGLTWTFGLLFINQESIVMAYIFTILNSLQGL 237
                        250
                 ....*....|....
gi 767973889 773 FIFLFHCLLNSEVR 786
Cdd:cd15440  238 FIFIFHCVLNEKVR 251
7tm_classB cd13952
class B family of seven-transmembrane G protein-coupled receptors; The class B of ...
536-789 8.70e-73

class B family of seven-transmembrane G protein-coupled receptors; The class B of seven-transmembrane GPCRs is classified into three major subfamilies: subfamily B1 (secretin-like receptor family), B2 (adhesion family), and B3 (Methuselah-like family). The class B receptors have been identified in all the vertebrates, from fishes to mammals, as well as invertebrates including Caenorhabditis elegans and Drosophila melanogaster, but are not present in plants, fungi or prokaryotes. The B1 subfamily comprises receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), calcitonin gene-related peptide, parathyroid hormone (PTH), and corticotropin-releasing factor. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of the subfamily B1 receptors preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. The subfamily B2 consists of cell-adhesion receptors with 33 members in humans and vertebrates. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing a variety of structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, linked to a class B seven-transmembrane domain. These include, for example, EGF (epidermal growth factor)-like domains in CD97, Celsr1 (cadherin family member), Celsr2, Celsr3, EMR1 (EGF-module-containing mucin-like hormone receptor-like 1), EMR2, EMR3, and Flamingo; two laminin A G-type repeats and nine cadherin domains in Flamingo and its human orthologs Celsr1, Celsr2 and Celsr3; olfactomedin-like domains in the latrotoxin receptors; and five or four thrombospondin type 1 repeats in BAI1 (brain-specific angiogenesis inhibitor 1), BAI2 and BAI3. Almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. Furthermore, the subfamily B3 includes Methuselah (Mth) protein, which was originally identified in Drosophila as a GPCR affecting stress resistance and aging, and its closely related proteins.


Pssm-ID: 410627 [Multi-domain]  Cd Length: 260  Bit Score: 239.04  E-value: 8.70e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 536 VALSSISYVGCSLSVLCLVATLVTFAVLSSvstIRNQRYHIHANLSFAVLVAQVLLLISFRLE--PGTTPCQVMAVLLHY 613
Cdd:cd13952    2 LALSIITYIGCSLSLVGLLLTIITYLLFPK---LRNLRGKILINLCLSLLLAQLLFLIGQLLTssDRPVLCKALAILLHY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 614 FFLSAFAWMLVEGLHLYSMVIKVFG-SEDSKHRYYYGMGWGFPLLICIISLS-----FAMDSYGTSNNCWLSLASGAIWA 687
Cdd:cd13952   79 FLLASFFWMLVEAFDLYRTFVKVFGsSERRRFLKYSLYGWGLPLLIVIITAIvdfslYGPSPGYGGEYCWLSNGNALLWA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 688 FVAPALFVIVVNIGILIAVTRVISQISADNyKIHGDPSAFKLTAKAVAVLLPILGTSWVFGVLAV-NGCAVVFQYMFATL 766
Cdd:cd13952  159 FYGPVLLILLVNLVFFILTVRILLRKLRET-PKQSERKSDRKQLRAYLKLFPLMGLTWIFGILAPfVGGSLVFWYLFDIL 237
                        250       260
                 ....*....|....*....|...
gi 767973889 767 NSLQGLFIFLFHCLLNSEVRAAF 789
Cdd:cd13952  238 NSLQGFFIFLIFCLKNKEVRRLL 260
7tmB2_CELSR_Adhesion_IV cd15441
cadherin EGF LAG seven-pass G-type receptors, group IV adhesion GPCRs, member of the class B2 ...
536-792 2.56e-64

cadherin EGF LAG seven-pass G-type receptors, group IV adhesion GPCRs, member of the class B2 family of seven-transmembrane G protein-coupled receptors; The group IV adhesion GPCRs include the cadherin EGF LAG seven-pass G-type receptors (CELSRs) and their Drosophila homolog Flamingo (also known as Starry night). These receptors are also classified as that belongs to the EGF-TM7 group of subfamily B2 adhesion GPCRs, because they contain EGF-like domains. Functionally, the group IV receptors act as key regulators of many physiological processes such as endocrine cell differentiation, neuronal migration, dendrite growth, axon, guidance, lymphatic vessel and valve formation, and planar cell polarity (PCP) during embryonic development. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. In the case of CELSR/Flamingo/Starry night, their extracellular domains comprise nine cadherin repeats linked to a series of epidermal growth factor (EGF)-like and laminin globular (G)-like domains. The cadherin repeats contain sequence motifs that mediate calcium-dependent cell-cell adhesion by homophilic interactions. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. Three mammalian orthologs of Flamingo, Celsr1-3, are widely expressed in the nervous system from embryonic development until the adult stage. Each Celsr exhibits different expression patterns in the developing brain, suggesting that they serve distinct functions. Mutations of CELSR1 cause neural tube defects in the nervous system, while mutations of CELSR2 are associated with coronary heart disease. Moreover, CELSR1 and several other PCP signaling molecules, such as dishevelled, prickle, frizzled, have been shown to be upregulated in B lymphocytes of chronic lymphocytic leukemia patients. Celsr3 is expressed in both the developing and adult mouse brain. It has been functionally implicated in proper neuron migration and axon guidance in the CNS.


Pssm-ID: 320557 [Multi-domain]  Cd Length: 254  Bit Score: 215.96  E-value: 2.56e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 536 VALSSISYVGCSLSVLCLVATLVTFAVLSSVSTIRNqryHIHANLSFAVLVAQVLLLISFRLEPGTTPCQVMAVLLHYFF 615
Cdd:cd15441    2 LLLKIVTYIGIGISLVLLVIAFLVLSCLRGLQSNSN---SIHKNLVACLLLAELLFLLGINQTENLFPCKLIAILLHYFY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 616 LSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLICIISLSFAMDSYGTSNNCWLSLASGAIWAFVAPALFV 695
Cdd:cd15441   79 LSAFSWLLVESLHLYRMLTEPRDINHGHMRFYYLLGYGIPAIIVGLSVGLRPDGYGNPDFCWLSVNETLIWSFAGPIAFV 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 696 IVVNIGILIAVTRVISQISadnyKIHGDPSAFKLTAKAVAVLLPILGTSWVFGVLAVNGCAVVFQYMFATLNSLQGLFIF 775
Cdd:cd15441  159 IVITLIIFILALRASCTLK----RHVLEKASVRTDLRSSFLLLPLLGATWVFGLLAVNEDSELLHYLFAGLNFLQGLFIF 234
                        250
                 ....*....|....*..
gi 767973889 776 LFHCLLNSEVRAAFKHK 792
Cdd:cd15441  235 LFYCIFNKKVRRELKNA 251
7tm_2 pfam00002
7 transmembrane receptor (Secretin family); This family is known as Family B, the ...
538-774 2.96e-63

7 transmembrane receptor (Secretin family); This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs). They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteriztic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.


Pssm-ID: 459625 [Multi-domain]  Cd Length: 248  Bit Score: 212.91  E-value: 2.96e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889  538 LSSISYVGCSLSVLCLvatLVTFAVLSSVSTIRNQRYHIHANLSFAVLVAQVLLLISFRLEPGTTP--------CQVMAV 609
Cdd:pfam00002   4 LKVIYTVGYSLSLVAL---LLAIAIFLLFRKLHCTRNYIHLNLFASFILRALLFLVGDAVLFNKQDldhcswvgCKVVAV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889  610 LLHYFFLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLICIISLSFAMDSYGTSNNCWLSLASGAIWAFV 689
Cdd:pfam00002  81 FLHYFFLANFFWMLVEGLYLYTLLVEVFFSERKYFWWYLLIGWGVPALVVGIWAGVDPKGYGEDDGCWLSNENGLWWIIR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889  690 APALFVIVVNIGILIAVTRVISQISADNYKIHGDPSAFKLTAKAVAVLLPILGTSWVFGVLAVN---GCAVVFQYMFATL 766
Cdd:pfam00002 161 GPILLIILVNFIIFINIVRILVQKLRETNMGKSDLKQYRRLAKSTLLLLPLLGITWVFGLFAFNpenTLRVVFLYLFLIL 240

                  ....*...
gi 767973889  767 NSLQGLFI 774
Cdd:pfam00002 241 NSFQGFFV 248
7tmB2_Latrophilin_Adhesion_I cd15252
Latrophilins and similar receptors, group I adhesion GPCRs, member of class B2 family of ...
535-789 3.67e-59

Latrophilins and similar receptors, group I adhesion GPCRs, member of class B2 family of seven-transmembrane G protein-coupled receptors; Group I adhesion GPCRs consist of latrophilins (also called lectomedins or latrotoxin receptors) and ETL (EGF-TM7-latrophilin-related protein. These receptors are a member of the adhesion family (subclass B2) that belongs to the class B GPCRs. Three subtypes of latrophilins have been identified: LPH1 (latrophilin-1), LPH2, and LPH3. The latrophilin-1 is a brain-specific calcium-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. Latrophilin-2 and -3, although sharing strong sequence homology to latrophilin-1, do not bind alpha-latrotoxin. While latrophilin-3 is also brain specific, latrophilin-2 is ubiquitously distributed. The endogenous ligands for these two receptors are unknown. ETL, a seven transmembrane receptor containing EGF-like repeats is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. The function of the ETL is unknown. All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320380 [Multi-domain]  Cd Length: 257  Bit Score: 201.97  E-value: 3.67e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 535 QVALSSISYVGCSLSVLCLVATLVTFAVLSSVSTIRNQryhIHANLSFAVLVAQVLLLISFRLEPGTTPCQVMAVLLHYF 614
Cdd:cd15252    1 YNILTRITQVGIIISLVCLAICIFTFWFFRGLQSDRTT---IHKNLCISLFLAELVFLIGINTTTNKIFCSVIAGLLHYF 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 615 FLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLICIISLSFAMDSYGTSNNCWLSLASGAIWAFVAPALF 694
Cdd:cd15252   78 FLAAFAWMFIEGIQLYLMLVEVFENEGSRHKNFYIFGYGSPAVIVGVSAALGYRYYGTTKVCWLSTENYFIWSFIGPATL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 695 VIVVNIGILIAVTRVISQISADNYKIHGDPSAFKLTAKAVAVLLPILGTSWVFGVLAVNGCAVVFQYMFATLNSLQGLFI 774
Cdd:cd15252  158 IILLNLIFLGVAIYKMFRHTAGLKPEVSCLENIRSWARGAIALLFLLGLTWIFGVLHINHASVVMAYLFTVSNSLQGMFI 237
                        250
                 ....*....|....*
gi 767973889 775 FLFHCLLNSEVRAAF 789
Cdd:cd15252  238 FLFHCVLSRKVRKEY 252
7tmB2_EMR cd15439
epidermal growth factor-like module-containing mucin-like hormone receptors, member of the ...
537-790 8.54e-57

epidermal growth factor-like module-containing mucin-like hormone receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors; group II adhesion GPCRs, including the epidermal growth factor (EGF)-module-containing, mucin-like hormone receptor (EMR1-4) and the leukocyte cell-surface antigen CD97, are primarily expressed in cells of the immune system. All EGF-TM7 receptors, which belong to the B2 subfamily of adhesion GPCRs, are members of group II, except for ETL (EGF-TM7-latrophilin related protein), which is classified into group I. Members of the EGF-TM7 receptors are characterized by the presence of varying number of N-terminal EGF-like domains, which play critical roles in ligand recognition and cell adhesion, linked by a stalk region to a class B seven-transmembrane domain. In the case of EMR2, alternative splicing results in four isoforms possessing either two (EGF1,2), three (EGF1,2,5), four (EGF1,2,3,5) or five (EGF1,2,3,4,5) EGF-like domains. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. EMR2 shares strong sequence homology with CD97, differing by only six amino acids. CD97 is widely expressed on lymphocytes, monocytes, macrophages, dendritic cells, granulocytes and smooth muscle cells as well as in a variety of human tumors including colorectal, gastric, esophageal pancreatic, and thyroid carcinoma. However, unlike CD97, EMR2 is not found in those of CD97-positive tumor cells and is not expressed on lymphocytes but instead on monocytes, macrophages and granulocytes. CD97 has three known ligands: CD55, decay-accelerating factor for regulation of complement system; chondroitin sulfate, a glycosaminoglycan found in the extracellular matrix; and the integrin alpha5beta1, which play a role in angiogenesis. Although EMR2 does not effectively interact with CD55, the fourth EGF-like domain of this receptor binds to chondroitin sulfate to mediate cell attachment.


Pssm-ID: 320555 [Multi-domain]  Cd Length: 263  Bit Score: 195.64  E-value: 8.54e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 537 ALSSISYVGCSLSVLCLVATLVTFAVLSSvstIRNQRYHIHANLSFAVLVAQVLLLISFRLEPGTTPCQVMAVLLHYFFL 616
Cdd:cd15439    3 ALTVITYVGLIISLLCLFLAILTFLLCRS---IRNTSTSLHLQLSLCLFLADLLFLVGIDRTDNKVLCSIIAGFLHYLFL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 617 SAFAWMLVEGLHLYSMV-----IKVFGSEDSKHRYYYGMGWGFPLLICIISLSFAMDSYGTSNNCWLSLASGAIWAFVAP 691
Cdd:cd15439   80 ACFAWMFLEAVHLFLTVrnlkvVNYFSSHRFKKRFMYPVGYGLPAVIVAISAAVNPQGYGTPKHCWLSMEKGFIWSFLGP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 692 ALFVIVVNIgILIAVTRVI--SQISADNykihGDPSAFK----LTAKAVAVLLpILGTSWVFGVLAVNGCAVVFQYMFAT 765
Cdd:cd15439  160 VCVIIVINL-VLFCLTLWIlrEKLSSLN----AEVSTLKntrlLTFKAIAQLF-ILGCTWILGLFQVGPVATVMAYLFTI 233
                        250       260
                 ....*....|....*....|....*
gi 767973889 766 LNSLQGLFIFLFHCLLNSEVRAAFK 790
Cdd:cd15439  234 TNSLQGVFIFLVHCLLNRQVREEYR 258
7tmB2_CD97 cd15438
CD97 antigen, member of the class B2 family of seven-transmembrane G protein-coupled receptors; ...
538-789 1.27e-56

CD97 antigen, member of the class B2 family of seven-transmembrane G protein-coupled receptors; group II adhesion GPCRs, including the leukocyte cell-surface antigen CD97 and the epidermal growth factor (EGF)-module-containing, mucin-like hormone receptor (EMR1-4), are primarily expressed in cells of the immune system. All EGF-TM7 receptors, which belong to the B2 subfamily B2 of adhesion GPCRs, are members of group II, except for ETL (EGF-TM7-latrophilin related protein), which is classified into group I. Members of the EGF-TM7 receptors are characterized by the presence of varying numbers of N-terminal EGF-like domains, which play critical roles in ligand recognition and cell adhesion, linked by a stalk region to a class B seven-transmembrane domain. In the case of CD97, alternative splicing results in three isoforms possessing either three (EGF1,2,5), four (EGF1,2,3,5) or five (EGF1,2,3,4,5) EGF-like domains. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. For example, CD97, which is involved in angiogenesis and the migration and invasion of tumor cells, has been shown to promote cell aggregation in a GPS proteolysis-dependent manner. CD97 is widely expressed on lymphocytes, monocytes, macrophages, dendritic cells, granulocytes and smooth muscle cells as well as in a variety of human tumors including colorectal, gastric, esophageal pancreatic, and thyroid carcinoma. EMR2 shares strong sequence homology with CD97, differing by only six amino acids. However, unlike CD97, EMR2 is not found in those of CD97-positive tumor cells and is not expressed on lymphocytes but instead on monocytes, macrophages and granulocytes. CD97 has three known ligands: CD55, decay-accelerating factor for regulation of complement system; chondroitin sulfate, a glycosaminoglycan found in the extracellular matrix; and the integrin alpha5beta1, which play a role in angiogenesis. Although EMR2 does not effectively interact with CD55, the fourth EGF-like domain of this receptor binds to chondroitin sulfate to mediate cell attachment.


Pssm-ID: 320554 [Multi-domain]  Cd Length: 261  Bit Score: 195.37  E-value: 1.27e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 538 LSSISYVGCSLSVLCLVATLVTFAVLSSVSTIRNQryhIHANLSFAVLVAQVLLLISFRLEPGTTPCQVMAVLLHYFFLS 617
Cdd:cd15438    4 LTLITKVGLSVSLFCLFLCILTFLFCRSIRGTRNT---IHLHLCLSLFLAHLIFLLGINNTNNQVACAVVAGLLHYFFLA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 618 AFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLICIISLSFAMDSYGTSNNCWLSLASGAIWAFVAPALFVIV 697
Cdd:cd15438   81 AFCWMSLEGVELYLMVVQVFNTQSLKKRYLLLIGYGVPLVIVAISAAVNSKGYGTQRHCWLSLERGFLWSFLGPVCLIIL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 698 VNIGI-LIAVTRVISQISADNYKIHGDPSAFKLTAKAVAVLLpILGTSWVFGVLAVNGCAVVFQYMFATLNSLQGLFIFL 776
Cdd:cd15438  161 VNAIIfVITVWKLAEKFSSINPDMEKLRKIRALTITAIAQLC-ILGCTWIFGFFQFSDSTLVMSYLFTILNSLQGLFIFL 239
                        250
                 ....*....|...
gi 767973889 777 FHCLLNSEVRAAF 789
Cdd:cd15438  240 LHCLLSKQVREEY 252
7tmB2_Latrophilin-1 cd16007
Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled ...
535-789 3.39e-55

Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Latrophilins (also called lectomedins or latrotoxin receptors) belong to Group I adhesion GPCRs, which also include ETL (EGF-TM7-latrophilin-related protein). These receptors are a member of the adhesion family (subclass B2) that belongs to the class B GPCRs. Three subtypes of latrophilins have been identified: LPH1 (latrophilin-1), LPH2, and LPH3. The latrophilin-1 is a brain-specific calcium-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. Latrophilin-2 and -3, although sharing strong sequence homology to latrophilin-1, do not bind alpha-latrotoxin. While latrophilin-3 is also brain specific, latrophilin-2 is ubiquitously distributed. The endogenous ligands for these two receptors are unknown. ETL, a seven transmembrane receptor containing EGF-like repeats is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. The function of the ETL is unknown. All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320673 [Multi-domain]  Cd Length: 258  Bit Score: 191.29  E-value: 3.39e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 535 QVALSSISYVGCSLSVLCLVATLVTFAVLSSVSTIRNQryhIHANLSFAVLVAQVLLLISFRLEPGTTPCQVMAVLLHYF 614
Cdd:cd16007    1 ELLLSVITWVGIVISLVCLAICISTFCFLRGLQTDRNT---IHKNLCINLFLAELLFLIGIDKTQYQIACPIFAGLLHFF 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 615 FLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLICIISLSFAMDSYGTSNNCWLSLASGAIWAFVAPALF 694
Cdd:cd16007   78 FLAAFSWLCLEGVQLYLMLVEVFESEYSRKKYYYLCGYCFPALVVGISAAIDYRSYGTEKACWLRVDNYFIWSFIGPVSF 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 695 VIVVNIGILIA----VTRVISQISADNYKIHGdpsaFKLTAKAVAVLLPILGTSWVFGVLAVNGCAVVFQYMFATLNSLQ 770
Cdd:cd16007  158 VIVVNLVFLMVtlhkMIRSSSVLKPDSSRLDN----IKSWALGAITLLFLLGLTWAFGLLFINKESVVMAYLFTTFNAFQ 233
                        250
                 ....*....|....*....
gi 767973889 771 GLFIFLFHCLLNSEVRAAF 789
Cdd:cd16007  234 GMFIFIFHCALQKKVHKEY 252
7tmB2_GPR144 cd15255
orphan adhesion receptor GPR114, member of the class B2 family of seven-transmembrane G ...
538-790 7.29e-51

orphan adhesion receptor GPR114, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR144 is an orphan receptor that belongs to the group V adhesion-GPCRs together with GPR133. The function of GPR144 has not yet been characterized, whereas GPR133 is highly expressed in the pituitary gland and is coupled to the Gs protein, leading to activation of adenylyl cyclase pathway. Moreover, genetic variations in the GPR133 have been reported to be associated with adult height and heart rate. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in ligand recognition as well as cell-cell adhesion and cell-matrix interactions, linked by a stalk region to a class B seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. However, several adhesion GPCRs, including GPR 111, GPR115, and CELSR1, are predicted to be non-cleavable at the GAIN domain because of the lack of a consensus catalytic triad sequence (His-Leu-Ser/Thr) within their GPS.


Pssm-ID: 320383 [Multi-domain]  Cd Length: 263  Bit Score: 179.27  E-value: 7.29e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 538 LSSISYVGCSLSvlcLVATLVTFAVLSSVSTIRNQRYHIHANLSFAVLVAQVLLLISFRLEPGTTPCQVMAVLLHYFFLS 617
Cdd:cd15255    4 LRTLSFIGCGVS---LCALIVTFILFLAVGVPKSERTTVHKNLIFALAAAEFLLMFSEWAKGNQVACWAVTALLHLFFLA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 618 AFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLICIISLSFAMDSYGTSNNCWLSLASGAIWAFVAPALFVIV 697
Cdd:cd15255   81 AFSWMLVEGLLLWSKVVAVNMSEDRRMKFYYVTGWGLPVVIVAVTLATSFNKYVADQHCWLNVQTDIIWAFVGPVLFVLT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 698 VNIGILIAVTRVISQISADNYKIHGDPSAFKL--------TAKAVAVLLPILGTSWVFGVLAvnGCAVVFQYMFATLNSL 769
Cdd:cd15255  161 VNTFVLFRVVMVTVSSARRRAKMLTPSSDLEKqigiqiwaTAKPVLVLLPVLGLTWLCGVLV--HLSDVWAYVFITLNSF 238
                        250       260
                 ....*....|....*....|.
gi 767973889 770 QGLFIFLFHCLLNSEVRAAFK 790
Cdd:cd15255  239 QGLYIFLVYAIYNSEVRNAIQ 259
7tmB2_EMR_Adhesion_II cd15931
EGF-like module receptors, group II adhesion GPCRs, member of class B2 family of ...
538-790 9.00e-50

EGF-like module receptors, group II adhesion GPCRs, member of class B2 family of seven-transmembrane G protein-coupled receptors; group II adhesion GPCRs, including the leukocyte cell-surface antigen CD97 and the epidermal growth factor (EGF)-module-containing, mucin-like hormone receptor (EMR1-4), are primarily expressed in cells of the immune system. All EGF-TM7 receptors, which belong to the B2 subfamily B2 of adhesion GPCRs, are members of group II, except for ETL (EGF-TM7-latrophilin related protein), which is classified into group I. Members of the EGF-TM7 receptors are characterized by the presence of varying numbers of N-terminal EGF-like domains, which play critical roles in ligand recognition and cell adhesion, linked by a stalk region to a class B seven-transmembrane domain. In the case of CD97, alternative splicing results in three isoforms possessing either three (EGF1,2,5), four (EGF1,2,3,5) or five (EGF1,2,3,4,5) EGF-like domains. On the other hand, EMR2 generates four isoforms possessing either two (EGF1,2), three (EGF1,2,5), four (EGF1,2,3,5) or five (EGF1,2,3,4,5) EGF-like domains. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. For example, CD97, which is involved in angiogenesis and the migration and invasion of tumor cells, has been shown to promote cell aggregation in a GPS proteolysis-dependent manner. CD97 is widely expressed on lymphocytes, monocytes, macrophages, dendritic cells, granulocytes and smooth muscle cells as well as in a variety of human tumors including colorectal, gastric, esophageal pancreatic, and thyroid carcinoma. EMR2 shares strong sequence homology with CD97, differing by only six amino acids. However, unlike CD97, EMR2 is not found in those of CD97-positive tumor cells and is not expressed on lymphocytes but instead on monocytes, macrophages and granulocytes. CD97 has three known ligands: CD55, decay-accelerating factor for regulation of complement system; chondroitin sulfate, a glycosaminoglycan found in the extracellular matrix; and the integrin alpha5beta1, which play a role in angiogenesis. Although EMR2 does not effectively interact with CD55, the fourth EGF-like domain of this receptor binds to chondroitin sulfate to mediate cell attachment.


Pssm-ID: 320597 [Multi-domain]  Cd Length: 262  Bit Score: 176.17  E-value: 9.00e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 538 LSSISYVGCSLSVLCLVATLVTFAVlssVSTIRNQRYHIHANLSFAVLVAQVLLLISFRLEPGTTPCQVMAVLLHYFFLS 617
Cdd:cd15931    4 LEWINRVGVIVSLFCLGLAIFTFLL---CRWIPKINTTAHLHLCLCLSMSHTLFLAGIEYVENELACTVMAGLLHYLFLA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 618 AFAWMLVEGLHLYSMV-----IKVFGSEDSKHRYYYGMGWGFPLLICIISLSFAMDSYGTSNNCWLSLASGAIWAFVAPA 692
Cdd:cd15931   81 SFVWMLLEALQLHLLVrrltkVQVIQRDGLPRPLLCLIGYGVPFLIVGVSALVYSDGYGEAKMCWLSQERGFNWSFLGPV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 693 LFVIVVNIGILIAVTRVISQ-ISADNYKIHGDPSAFKLTAKAVAVLLpILGTSWVFGVLAVNGCAVVFQYMFATLNSLQG 771
Cdd:cd15931  161 IAIIGINWILFCATLWCLRQtLSNMNSDISQLKDTRLLTFKAVAQLF-ILGCTWVLGLFQTNPVALVFQYLFTILNSLQG 239
                        250
                 ....*....|....*....
gi 767973889 772 LFIFLFHCLLNSEVRAAFK 790
Cdd:cd15931  240 AFLFLVHCLLNKEVREEYI 258
7tmB2_CELSR1 cd15991
Cadherin EGF LAG seven-pass G-type receptor 1, member of the class B2 family of ...
538-790 2.46e-49

Cadherin EGF LAG seven-pass G-type receptor 1, member of the class B2 family of seven-transmembrane G protein-coupled receptors; The group IV adhesion GPCRs include the cadherin EGF LAG seven-pass G-type receptors (CELSRs) and their Drosophila homolog Flamingo (also known as Starry night). These receptors are also classified as that belongs to the EGF-TM7 group of subfamily B2 adhesion GPCRs, because they contain EGF-like domains. Functionally, the group IV receptors act as key regulators of many physiological processes such as endocrine cell differentiation, neuronal migration, dendrite growth, axon, guidance, lymphatic vessel and valve formation, and planar cell polarity (PCP) during embryonic development. Three mammalian orthologs of Flamingo, Celsr1-3, are widely expressed in the nervous system from embryonic development until the adult stage. Each Celsr exhibits different expression patterns in the developing brain, suggesting that they serve distinct functions. Mutations of CELSR1 cause neural tube defects in the nervous system, while mutations of CELSR2 are associated with coronary heart disease. Moreover, CELSR1 and several other PCP signaling molecules, such as dishevelled, prickle, frizzled, have been shown to be upregulated in B lymphocytes of chronic lymphocytic leukemia patients. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. In the case of CELSR/Flamingo/Starry night, their extracellular domains comprise nine cadherin repeats linked to a series of epidermal growth factor (EGF)-like and laminin globular (G)-like domains. The cadherin repeats contain sequence motifs that mediate calcium-dependent cell-cell adhesion by homophilic interactions. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320657 [Multi-domain]  Cd Length: 254  Bit Score: 174.65  E-value: 2.46e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 538 LSSISYVGCSLSvlcLVATLVTFAVLSSVSTIRNQRYHIHANLSFAVLVAQVLLLISFRLEPGTTPCQVMAVLLHYFFLS 617
Cdd:cd15991    4 LKIITYTTVSLS---LVALLITFILLVLIRTLRSNLHSIHKNLVAALFFSELIFLIGINQTENPFVCTVVAILLHYFYMS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 618 AFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLICIISLSFAMDSYGTSNNCWLSLASGAIWAFVAPALFVIV 697
Cdd:cd15991   81 TFAWMFVEGLHIYRMLTEVRNINTGHMRFYYVVGWGIPAIITGLAVGLDPQGYGNPDFCWLSVQDTLIWSFAGPIGIVVI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 698 VNIGILIAVTRVISQISADNYKIHGDPSAFkltaKAVAVLLPILGTSWVFGVLAVNGCAVVFQYMFATLNSLQGLFIFLF 777
Cdd:cd15991  161 INTVIFVLAAKASCGRRQRYFEKSGVISML----RTAFLLLLLISATWLLGLMAVNSDTLSFHYLFAIFSCLQGIFIFFF 236
                        250
                 ....*....|...
gi 767973889 778 HCLLNSEVRAAFK 790
Cdd:cd15991  237 HCIFNKEVRKHLK 249
7tmB2_Latrophilin-2 cd16006
Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled ...
535-789 7.65e-49

Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Latrophilins (also called lectomedins or latrotoxin receptors) belong to Group I adhesion GPCRs, which also include ETL (EGF-TM7-latrophilin-related protein). These receptors are a member of the adhesion family (subclass B2) that belongs to the class B GPCRs. Three subtypes of latrophilins have been identified: LPH1 (latrophilin-1), LPH2, and LPH3. The latrophilin-1 is a brain-specific calcium-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. Latrophilin-2 and -3, although sharing strong sequence homology to latrophilin-1, do not bind alpha-latrotoxin. While latrophilin-3 is also brain specific, latrophilin-2 is ubiquitously distributed. The endogenous ligands for these two receptors are unknown. ETL, a seven transmembrane receptor containing EGF-like repeats is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. The function of the ETL is unknown. All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320672 [Multi-domain]  Cd Length: 258  Bit Score: 173.56  E-value: 7.65e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 535 QVALSSISYVGCSLSVLCLVATLVTFAVLSSVSTIRNQryhIHANLSFAVLVAQVLLLISFRLEPGTTPCQVMAVLLHYF 614
Cdd:cd16006    1 ELLLTVITWVGIVISLVCLAICIFTFCFFRGLQSDRNT---IHKNLCINLFIAEFIFLIGIDKTEYKIACPIFAGLLHFF 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 615 FLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLICIISLSFAMDSYGTSNNCWLSLASGAIWAFVAPALF 694
Cdd:cd16006   78 FLAAFAWMCLEGVQLYLMLVEVFESEYSRKKYYYVAGYLFPATVVGVSAAIDYKSYGTEKACWLRVDNYFIWSFIGPVTF 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 695 VIVVNIGILI----AVTRVISQISADNYKIHGdpsaFKLTAKAVAVLLPILGTSWVFGVLAVNGCAVVFQYMFATLNSLQ 770
Cdd:cd16006  158 IILLNLIFLVitlcKMVKHSNTLKPDSSRLEN----IKSWVLGAFALLCLLGLTWSFGLLFINEETIVMAYLFTIFNAFQ 233
                        250
                 ....*....|....*....
gi 767973889 771 GLFIFLFHCLLNSEVRAAF 789
Cdd:cd16006  234 GMFIFIFHCALQKKVRKEY 252
7tmB2_Latrophilin-3 cd16005
Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled ...
538-789 8.61e-49

Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Latrophilins (also called lectomedins or latrotoxin receptors) belong to Group I adhesion GPCRs, which also include ETL (EGF-TM7-latrophilin-related protein). These receptors are a member of the adhesion family (subclass B2) that belongs to the class B GPCRs. Three subtypes of latrophilins have been identified: LPH1 (latrophilin-1), LPH2, and LPH3. The latrophilin-1 is a brain-specific calcium-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. Latrophilin-2 and -3, although sharing strong sequence homology to latrophilin-1, do not bind alpha-latrotoxin. While latrophilin-3 is also brain specific, latrophilin-2 is ubiquitously distributed. The endogenous ligands for these two receptors are unknown. ETL, a seven transmembrane receptor containing EGF-like repeats is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. The function of the ETL is unknown. All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320671 [Multi-domain]  Cd Length: 258  Bit Score: 173.59  E-value: 8.61e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 538 LSSISYVGCSLSVLCLVATLVTFAVLSSVSTIRNQryhIHANLSFAVLVAQVLLLISFRLEPGTTPCQVMAVLLHYFFLS 617
Cdd:cd16005    4 LDVITWVGILLSLVCLLICIFTFCFFRGLQSDRNT---IHKNLCISLFVAELLFLIGINRTDQPIACAVFAALLHFFFLA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 618 AFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLICIISLSFAMDSYGTSNNCWLSLASGAIWAFVAPALFVIV 697
Cdd:cd16005   81 AFTWMFLEGVQLYIMLVEVFESEHSRRKYFYLVGYGMPALIVAVSAAVDYRSYGTDKVCWLRLDTYFIWSFIGPATLIIM 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 698 VNIGIL-IAVTRVISQISADNYKIHGDPSAFKLTAKAVAvLLPILGTSWVFGVLAVNGCAVVFQYMFATLNSLQGLFIFL 776
Cdd:cd16005  161 LNVIFLgIALYKMFHHTAILKPESGCLDNIKSWVIGAIA-LLCLLGLTWAFGLMYINESTVIMAYLFTIFNSLQGMFIFI 239
                        250
                 ....*....|...
gi 767973889 777 FHCLLNSEVRAAF 789
Cdd:cd16005  240 FHCVLQKKVRKEY 252
7tmB2_Latrophilin cd15436
Latrophilins, member of the class B2 family of seven-transmembrane G protein-coupled receptors; ...
538-786 2.06e-48

Latrophilins, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Latrophilins (also called lectomedins or latrotoxin receptors) belong to Group I adhesion GPCRs, which also include ETL (EGF-TM7-latrophilin-related protein). These receptors are a member of the adhesion family (subclass B2) that belongs to the class B GPCRs. Three subtypes of latrophilins have been identified: LPH1 (latrophilin-1), LPH2, and LPH3. The latrophilin-1 is a brain-specific calcium-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. Latrophilin-2 and -3, although sharing strong sequence homology to latrophilin-1, do not bind alpha-latrotoxin. While latrophilin-3 is also brain specific, latrophilin-2 is ubiquitously distributed. The endogenous ligands for these two receptors are unknown. ETL, a seven transmembrane receptor containing EGF-like repeats is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. The function of the ETL is unknown. All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320552 [Multi-domain]  Cd Length: 258  Bit Score: 172.28  E-value: 2.06e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 538 LSSISYVGCSLSVLCLVATLVTFAVLSSVSTIRNQryhIHANLSFAVLVAQVLLLISFRLEPGTTPCQVMAVLLHYFFLS 617
Cdd:cd15436    4 LFVITWVGIVISLVCLLICIFTFCFFRGLQTDRNT---IHKNLCINLFIAELLFLIGINRTQYTIACPIFAGLLHFFFLA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 618 AFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLICIISLSFAMDSYGTSNNCWLSLASGAIWAFVAPALFVIV 697
Cdd:cd15436   81 AFCWLCLEGVQLYLLLVEVFESEYSRRKYFYLCGYSFPALVVAVSAAIDYRSYGTEKACWLRVDNYFIWSFIGPVTFVIT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 698 VNIGIL-IAVTRVI--SQISADNYKIHGDPSAFKLTAKAvavLLPILGTSWVFGVLAVNGCAVVFQYMFATLNSLQGLFI 774
Cdd:cd15436  161 LNLVFLvITLHKMVshSDLLKPDSSRLDNIKSWALGAIA---LLFLLGLTWSFGLMFINEESVVMAYLFTIFNAFQGVFI 237
                        250
                 ....*....|..
gi 767973889 775 FLFHCLLNSEVR 786
Cdd:cd15436  238 FIFHCALQKKVR 249
7tmB2_CELSR3 cd15993
Cadherin EGF LAG seven-pass G-type receptor 3, member of the class B2 family of ...
538-790 1.31e-45

Cadherin EGF LAG seven-pass G-type receptor 3, member of the class B2 family of seven-transmembrane G protein-coupled receptors; The group IV adhesion GPCRs include the cadherin EGF LAG seven-pass G-type receptors (CELSRs) and their Drosophila homolog Flamingo (also known as Starry night). These receptors are also classified as that belongs to the EGF-TM7 group of subfamily B2 adhesion GPCRs, because they contain EGF-like domains. Functionally, the group IV receptors act as key regulators of many physiological processes such as endocrine cell differentiation, neuronal migration, dendrite growth, axon, guidance, lymphatic vessel and valve formation, and planar cell polarity (PCP) during embryonic development. Three mammalian orthologs of Flamingo, Celsr1-3, are widely expressed in the nervous system from embryonic development until the adult stage. Each Celsr exhibits different expression patterns in the developing brain, suggesting that they serve distinct functions. Mutations of CELSR1 cause neural tube defects in the nervous system, while mutations of CELSR2 are associated with coronary heart disease. Moreover, CELSR1 and several other PCP signaling molecules, such as dishevelled, prickle, frizzled, have been shown to be upregulated in B lymphocytes of chronic lymphocytic leukemia patients. Celsr3 is expressed in both the developing and adult mouse brain. It has been functionally implicated in proper neuronal migration and axon guidance in the CNS. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. In the case of CELSR/Flamingo/Starry night, their extracellular domains comprise nine cadherin repeats linked to a series of epidermal growth factor (EGF)-like and laminin globular (G)-like domains. The cadherin repeats contain sequence motifs that mediate calcium-dependent cell-cell adhesion by homophilic interactions. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320659 [Multi-domain]  Cd Length: 254  Bit Score: 164.24  E-value: 1.31e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 538 LSSISYVGCSLSvlcLVATLVTFAVLSSVSTIRNQRYHIHANLSFAVLVAQVLLLISFRLEPGTTPCQVMAVLLHYFFLS 617
Cdd:cd15993    4 LAIVTYSSVSAS---LAALVLTFSVLTCLRGLKSNTRGIHSNIAAALFLSELLFLLGINRTENQFLCTVVAILLHYFFLS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 618 AFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLICIISLSFAMDSYGTSNNCWLSLASGAIWAFVAPALFVIV 697
Cdd:cd15993   81 TFAWLFVQGLHIYRMQTEARNVNFGAMRFYYAIGWGVPAIITGLAVGLDPEGYGNPDFCWISIHDKLVWSFAGPIVVVIV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 698 VNIGILIAVTRVISQISADNYKihgdPSAFKLTAKAVAVLLPILGTSWVFGVLAVNGCAVVFQYMFATLNSLQGLFIFLF 777
Cdd:cd15993  161 MNGVMFLLVARMSCSPGQKETK----KTSVLMTLRSSFLLLLLISATWLFGLLAVNNSVLAFHYLHAILCCLQGLAVLLL 236
                        250
                 ....*....|...
gi 767973889 778 HCLLNSEVRAAFK 790
Cdd:cd15993  237 FCVLNEEVQEAWK 249
7tmB2_ETL cd15437
Epidermal Growth Factor, latrophilin and seven transmembrane domain-containing protein 1; ...
538-786 9.74e-45

Epidermal Growth Factor, latrophilin and seven transmembrane domain-containing protein 1; member of the class B2 family of seven-transmembrane G protein-coupled receptors; ETL (EGF-TM7-latrophilin-related protein) belongs to Group I adhesion GPCRs, which also include latrophilins (also called lectomedins or latrotoxin receptors). All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. ETL, for instance, contains EGF-like repeats, which also present in other EGF-TM7 adhesion GPCRs, such as Cadherin EGF LAG seven-pass G-type receptors (CELSR1-3), EGF-like module receptors (EMR1-3), CD97, and Flamingo. ETL is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320553 [Multi-domain]  Cd Length: 258  Bit Score: 161.97  E-value: 9.74e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 538 LSSISYVGCSLSVLCLVATLVTFAVLSSvstIRNQRYHIHANLSFAVLVAQVLLLISFRLEPGTTPCQVMAVLLHYFFLS 617
Cdd:cd15437    4 LTRITQLGIIISLICLSMCIFTFWFFSE---IQSTRTTIHKNLCCSLFLAELIFLIGINMNANKLFCSIIAGLLHYFFLA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 618 AFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLICIISLSFAMDSYGTSNNCWLSLASGAIWAFVAPALFVIV 697
Cdd:cd15437   81 AFAWMCIEGIHLYLIVVGVIYNKGFLHKNFYIFGYGSPAVVVGISAALGYKYYGTTKVCWLSTENNFIWSFIGPACLIIL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 698 VNigiLIAVTRVISQISADNYKIHGDPSAF---KLTAKAVAVLLPILGTSWVFGVLAVNGCAVVFQYMFATLNSLQGLFI 774
Cdd:cd15437  161 VN---LLAFGVIIYKVFRHTAMLKPEVSCYeniRSCARGALALLFLLGATWIFGVLHVVYGSVVTAYLFTISNAFQGMFI 237
                        250
                 ....*....|..
gi 767973889 775 FLFHCLLNSEVR 786
Cdd:cd15437  238 FIFLCVLSRKIQ 249
7tmB2_GPR116-like_Adhesion_VI cd15932
orphan GPR116 and related proteins, group IV adhesion GPCRs, member of the class B2 family of ...
535-790 3.73e-43

orphan GPR116 and related proteins, group IV adhesion GPCRs, member of the class B2 family of seven-transmembrane G protein-coupled receptors; group VI adhesion GPCRs consist of orphan receptors GPR110, GPR111, GPR113, GPR115, GPR116, and closely related proteins. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in ligand recognition as well as cell-cell adhesion and cell-matrix interactions, linked by a stalk region to a class B seven-transmembrane domain. GPR110 possesses a SEA box in the N-terminal has been identified as an oncogene over-expressed in lung and prostate cancer. GPR113 contains a hormone binding domain and one EGF (epidermal grown factor) domain. GPR112 has extremely long N-terminus (about 2,400 amino acids) containing a number of Ser/Thr-rich glycosylation sites and a pentraxin (PTX) domain. GPR116 has two C2-set immunoglobulin-like repeats, which is found in the members of the immunoglobulin superfamily of cell surface proteins, and a SEA (sea urchin sperm protein, enterokinase, and a grin)-box, which is present in the extracellular domain of the transmembrane mucin (MUC) family and known to enhance O-glycosylation. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. However, several adhesion GPCRs, including GPR 111, GPR115, and CELSR1, are predicted to be non-cleavable at the GAIN domain because of the lack of a consensus catalytic triad sequence (His-Leu-Ser/Thr) within their GPS.


Pssm-ID: 320598 [Multi-domain]  Cd Length: 268  Bit Score: 157.86  E-value: 3.73e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 535 QVALSSISYVGCSLSVLCLVATLVTFAVLSSVSTIRNQRYHIHA---NLSFAVLVAQVLLLISFRLEPGTTP---CQVMA 608
Cdd:cd15932    1 SPALDYITYVGLGISILSLVLCLIIEALVWKSVTKNKTSYMRHVclvNIALSLLIADIWFIIGAAISTPPNPspaCTAAT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 609 VLLHYFFLSAFAWMLVEGLHLYSMVIKVFgSEDSKHRYY---YGMGWGFPLLICIISLSFAMDS--YGTSNNCWLSLA-S 682
Cdd:cd15932   81 FFIHFFYLALFFWMLTLGLLLFYRLVLVF-HDMSKSTMMaiaFSLGYGCPLIIAIITVAATAPQggYTRKGVCWLNWDkT 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 683 GAIWAFVAPALFVIVVNIGILIAVTRVISQISADNYKIHGDPSAFKLTAKAVAVLLPILGTSWVFGV-LAVNGCAVVFQY 761
Cdd:cd15932  160 KALLAFVIPALAIVVVNFIILIVVIFKLLRPSVGERPSKDEKNALVQIGKSVAILTPLLGLTWGFGLgTMIDPKSLAFHI 239
                        250       260
                 ....*....|....*....|....*....
gi 767973889 762 MFATLNSLQGLFIFLFHCLLNSEVRAAFK 790
Cdd:cd15932  240 IFAILNSFQGFFILVFGTLLDSKVREALL 268
7tmB1_hormone_R cd15041
The subfamily B1 of hormone receptors (secretin-like), member of the class B family ...
536-792 5.71e-41

The subfamily B1 of hormone receptors (secretin-like), member of the class B family seven-transmembrane G protein-coupled receptors; The B1 subfamily of class B GPCRs, also referred to as secretin-like receptor family, includes receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), calcitonin gene-related peptide, parathyroid hormone (PTH), and corticotropin-releasing factor. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of this subfamily preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. Moreover, the B1 subfamily receptors play key roles in hormone homeostasis and are promising drug targets in various human diseases including diabetes, osteoporosis, obesity, neurodegenerative conditions (Alzheimer###s and Parkinson's), cardiovascular disease, migraine, and psychiatric disorders (anxiety, depression). Furthermore, the subfamilies B2 and B3 consist of receptors that are capable of interacting with epidermal growth factors (EGF) and the Drosophila melanogaster Methuselah gene product (Mth), respectively. The class B GPCRs have been identified in all the vertebrates, from fishes to mammals, as well as invertebrates including Caenorhabditis elegans and Drosophila melanogaster, but are not present in plants, fungi, or prokaryotes.


Pssm-ID: 341321 [Multi-domain]  Cd Length: 273  Bit Score: 151.61  E-value: 5.71e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 536 VALSSISYVGCSLSVLCLVATLVTFAVLSSvstIRNQRYHIHANLSFAVLVAQVLLLISF------RLEPGTTP------ 603
Cdd:cd15041    2 LVVYYIYLVGYSLSLVALLPAIVIFLYFRS---LRCTRIRLHINLFLSFILRAVFWIIWDllvvydRLTSSGVEtvlmqn 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 604 ---CQVMAVLLHYFFLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLIcIISLSFAMDSYGTSnNCWLSL 680
Cdd:cd15041   79 pvgCKLLSVLKRYFKSANYFWMLCEGLYLHRLIVVAFFSEPSSLKLYYAIGWGLPLVI-VVIWAIVRALLSNE-SCWISY 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 681 ASGAI-WAFVAPALFVIVVNIGILIAVTRV-ISQISADNykiHGDPSAFKLTAKAVAVLLPILGTSWVFGVLAVNGCAV- 757
Cdd:cd15041  157 NNGHYeWILYGPNLLALLVNLFFLINILRIlLTKLRSHP---NAEPSNYRKAVKATLILIPLFGIQYLLTIYRPPDGSEg 233
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 767973889 758 --VFQYMFATLNSLQGLFIFLFHCLLNSEVRAAFKHK 792
Cdd:cd15041  234 elVYEYFNAILNSSQGFFVAVIYCFLNGEVQSELKRK 270
7tmB2_GPR112 cd15997
Probable G protein-coupled receptor 112, member of the class B2 family of seven-transmembrane ...
538-786 1.57e-38

Probable G protein-coupled receptor 112, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR112 is an orphan receptor that has been classified as that belongs to the Group VIII of adhesion GPCRs. Other members of the Group VII include orphan GPCRs such as GPR56, GPR64, GPR97, GPR114, and GPR126. GPR112 is specifically expressed in normal enterochromatin cells and gastrointestinal neuroendocrine carcinoma cells, but its biological function is unknown. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320663  Cd Length: 269  Bit Score: 144.42  E-value: 1.57e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 538 LSSISYVGCSLSVLCLVATLVTFAVLSSVStiRNQRYHIHANLSFAVLVAQVLLLISFRLEPGTTP--CQVMAVLLHYFF 615
Cdd:cd15997    4 LTLITYLGCGISSIFLGITLVTYLAFEKLR--RDYPSKILINLCTALLMLNLVFLLNSWLSSFNNYglCITVAAFLHYFL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 616 LSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGM-GWGFPLLICIISLSFAMDSYGTS----------NNCWLSlasgA 684
Cdd:cd15997   82 LASFTWMGLEAVHMYFALVKVFNIYIPNYILKFCIaGWGIPAVVVALVLAINKDFYGNElssdslhpstPFCWIQ----D 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 685 IWAF----VAPALFVIVVNIGILIAVTRVISQISADNYKiHGDPSAFKLTAKAVAVLLPILGTSWVFGVLAVNGCAVVFQ 760
Cdd:cd15997  158 DVVFyisvVAYFCLIFLCNISMFITVLIQIRSMKAKKPS-RNWKQGFLHDLKSVASLTFLLGLTWGFAFFAWGPVRIFFL 236
                        250       260
                 ....*....|....*....|....*.
gi 767973889 761 YMFATLNSLQGLFIFLFHCLLNSEVR 786
Cdd:cd15997  237 YLFSICNTLQGFFIFVFHCLMKENVR 262
7tmB2_BAI_Adhesion_VII cd15251
brain-specific angiogenesis inhibitors, group VII adhesion GPCRs, member of the class B2 ...
544-790 5.32e-36

brain-specific angiogenesis inhibitors, group VII adhesion GPCRs, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Brain-specific angiogenesis inhibitors (BAI1-3) constitute the group VII of cell-adhesion receptors that have been implicated in vascularization of glioblastomas. They belong to the B2 subfamily of class B GPCRs, are predominantly expressed in the brain, and are only present in vertebrates. Three BAIs, like all adhesion receptors, are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. For example, BAI1 N-terminus contain an integrin-binding RGD (Arg-Gly-Asp) motif in addition to five thrombospondin type 1 repeats (TSRs), which are known to regulate the anti-angiogenic activity of thrombospondin-1, whereas BAI2 and BAI3 have four TSRs, but do not possess RGD motifs. The TSRs are functionally involved in cell attachment, activation of latent TGF-beta, inhibition of angiogenesis and endothelial cell migration. The TSRs of BAI1 mediate direct binding to phosphatidylserine, which enables both recognition and internalization of apoptotic cells by phagocytes. Thus, BAI1 functions as a phosphatidylserine receptor that forms a trimeric complex with ELMO and Dock180, leading to activation of Rac-GTPase which promotes the binding and phagocytosis of apoptotic cells. BAI3 can also interact with the ELMO-Dock180 complex to activate the Rac pathway and can also bind to secreted C1ql proteins of the C1Q complement family via its N-terminal TSRs. BAI3 and its ligands C1QL1 are highly expressed during synaptogenesis and are involved in synapse specificity. Moreover, BAI2 acts as a transcription repressor to regulate vascular endothelial growth factor (VEGF) expression through interaction with GA-binding protein gamma (GABP). The N-terminal extracellular domains of all three BAIs also contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain, which undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif to generate N- and C-terminal fragments (NTF and CTF), a putative hormone-binding domain (HBD), and multiple N-glycosylation sites. The C-terminus of each BAI subtype ends with a conserved Gln-Thr-Glu-Val (QTEV) motif known to interact with PDZ domain-containing proteins, but only BAI1 possesses a proline-rich region, which may be involved in protein-protein interactions.


Pssm-ID: 320379  Cd Length: 253  Bit Score: 136.62  E-value: 5.32e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 544 VGCSLSVLCLVATLVTFAVLSSVstIRNQRYHIHANLSFAVLVAQVLLLISFRLEPGTTPCQVMAVLLHYFFLSAFAWML 623
Cdd:cd15251   10 VGCGVSCLALLTLLAIYAAFWRY--IRSERSIILINFCLSIISSNILILVGQTQTLNKGVCTMTAAFLHFFFLSSFCWVL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 624 VEGLHLYSMVIKVFGSEDSKHRYYYgMGWGFPLLICIISLSFA-MDSYGTSNNCWLSLASGAIWAFVAPALFVIVVNIGI 702
Cdd:cd15251   88 TEAWQSYMAVTGRMRTRLIRKRFLC-LGWGLPALVVAVSVGFTrTKGYGTSSYCWLSLEGGLLYAFVGPAAAVVLVNMVI 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 703 LIAVTRVIsqISADNYKIHGDPSAFkltakAVAVLLPILGTSWVFGVLAV-NGCAVVFQYMFATLNSLQGLFIFLFHCLL 781
Cdd:cd15251  167 GILVFNKL--VSRDGISDNAMASLW-----SSCVVLPLLALTWMSAVLAMtDRRSVLFQILFAVFDSLQGFVIVMVHCIL 239

                 ....*....
gi 767973889 782 NSEVRAAFK 790
Cdd:cd15251  240 RREVQDAVK 248
7tmB2_CELSR2 cd15992
Cadherin EGF LAG seven-pass G-type receptor 2, member of the class B2 family of ...
553-790 6.06e-36

Cadherin EGF LAG seven-pass G-type receptor 2, member of the class B2 family of seven-transmembrane G protein-coupled receptors; The group IV adhesion GPCRs include the cadherin EGF LAG seven-pass G-type receptors (CELSRs) and their Drosophila homolog Flamingo (also known as Starry night). These receptors are also classified as that belongs to the EGF-TM7 group of subfamily B2 adhesion GPCRs, because they contain EGF-like domains. Functionally, the group IV receptors act as key regulators of many physiological processes such as endocrine cell differentiation, neuronal migration, dendrite growth, axon, guidance, lymphatic vessel and valve formation, and planar cell polarity (PCP) during embryonic development. Three mammalian orthologs of Flamingo, Celsr1-3, are widely expressed in the nervous system from embryonic development until the adult stage. Each Celsr exhibits different expression patterns in the developing brain, suggesting that they serve distinct functions. Mutations of CELSR1 cause neural tube defects in the nervous system, while mutations of CELSR2 are associated with coronary heart disease. Moreover, CELSR1 and several other PCP signaling molecules, such as dishevelled, prickle, frizzled, have been shown to be upregulated in B lymphocytes of chronic lymphocytic leukemia patients. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. In the case of CELSR/Flamingo/Starry night, their extracellular domains comprise nine cadherin repeats linked to a series of epidermal growth factor (EGF)-like and laminin globular (G)-like domains. The cadherin repeats contain sequence motifs that mediate calcium-dependent cell-cell adhesion by homophilic interactions. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320658  Cd Length: 255  Bit Score: 136.87  E-value: 6.06e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 553 LVATLVTFAVLSSVSTIRNQRYHIHANLSFAVLVAQVLLLISFRLEPGTTPCQVMAVLLHYFFLSAFAWMLVEGLHLYSM 632
Cdd:cd15992   16 LGFLLLTFLFLLCLRALRSNKTSIRKNGATALFLSELVFILGINQADNPFACTVIAILLHFFYLCTFSWLFLEGLHIYRM 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 633 VIKVFGSEDSKHRYYYGMGWGFPLLICIISLSFAMDSYGTSNNCWLSLASGAIWAFVAPALFVIVVNIGILIAVTRVISQ 712
Cdd:cd15992   96 LSEVRDINYGPMRFYYLIGWGVPAFITGLAVGLDPEGYGNPDFCWLSIYDTLIWSFAGPVAFAVSMNVFLYILSSRASCS 175
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767973889 713 ISADNYKIHGDPSAFKLTAKAVAVLLPIlgtSWVFGVLAVNGCAVVFQYMFATLNSLQGLFIFLFHCLLNSEVRAAFK 790
Cdd:cd15992  176 AQQQSFEKKKGPVSGLRTAFTVLLLVSV---TCLLALLSVNSDVILFHYLFAGFNCLQGPFIFLSHVVLLKEVRKALK 250
7tmB1_DH_R cd15263
insect diuretic hormone receptors, member of the class B family of seven-transmembrane G ...
539-791 1.08e-35

insect diuretic hormone receptors, member of the class B family of seven-transmembrane G protein-coupled receptors; This group includes G protein-coupled receptors that specifically bind to insect diuretic hormones found in Manduca sexta (moth) and Acheta domesticus (the house cricket), among others. Insect diuretic hormone and their GPCRs play critical roles in the regulation of water and ion balance. Thus they are attractive targets for developing new insecticides. Activation of the diuretic hormone receptors stimulate adenylate cyclase, thereby increasing cAMP levels in Malpighian tube. They belong to the B1 subfamily of class B GPCRs, also referred to as secretin-like receptor family, which includes receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), calcitonin gene-related peptide, parathyroid hormone (PTH), and corticotropin-releasing factor. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of the B1 subfamily preferentially couple to G proteins of Gs family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx.


Pssm-ID: 320391 [Multi-domain]  Cd Length: 272  Bit Score: 136.35  E-value: 1.08e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 539 SSISYVGCSLSVLCLVATLVTFAVLSSVSTIRNQryhIHANLSFAVLVAQVLLLISFRL----EPGTTPCQVMAVLLHYF 614
Cdd:cd15263    5 TTIYFIGYSLSLVALSLALWIFLYFKDLRCLRNT---IHTNLMFTYILADLTWILTLTLqvsiGEDQKSCIILVVLLHYF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 615 FLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLICII----------SLSFAMDSYGTSNNCWLSLASGA 684
Cdd:cd15263   82 HLTNFFWMFVEGLYLYMLVVETFSGENIKLRVYAFIGWGIPAVVIVIwaivkalaptAPNTALDPNGLLKHCPWMAEHIV 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 685 IWAFVAPALFVIVVNIGILIAVTRV-ISQI-SADNYkihgDPSAFKLTAKAVAVLLPILGTSWVFgVLAV---NGCAVVF 759
Cdd:cd15263  162 DWIFQGPAILVLAVNLVFLVRIMWVlITKLrSANTV----ETQQYRKAAKALLVLIPLLGITYIL-VIAGpteGIAANIF 236
                        250       260       270
                 ....*....|....*....|....*....|..
gi 767973889 760 QYMFATLNSLQGLFIFLFHCLLNSEVRAAFKH 791
Cdd:cd15263  237 EYVRAVLLSTQGFTVALFYCFLNTEVRNTLRH 268
7tmB3_Methuselah-like cd15039
Methuselah-like subfamily B3, member of the class B family of seven-transmembrane G ...
537-792 2.20e-35

Methuselah-like subfamily B3, member of the class B family of seven-transmembrane G protein-coupled receptors; The subfamily B3 of class B GPCRs consists of Methuselah (Mth) and its closely related proteins found in bilateria. Mth was originally identified in Drosophila as a GPCR affecting stress resistance and aging. In addition to the seven transmembrane helices, Mth contains an N-terminal extracellular domain involved in ligand binding, and a third intracellular loop (IC3) required for the specificity of G-protein coupling. Drosophila Mth mutants showed an increase in average lifespan by 35% and greater resistance to a variety of stress factors, including starvation, high temperature, and paraquat-induced oxidative toxicity. Moreover, mutations in two endogenous peptide ligands of Methuselah, Stunted A and B, showed an increased in lifespan and resistance to oxidative stress induced by dietary paraquat. These results strongly suggest that the Stunted-Methuselah system plays important roles in stress response and aging.


Pssm-ID: 410632 [Multi-domain]  Cd Length: 270  Bit Score: 135.43  E-value: 2.20e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 537 ALSSISYVGCSLSVLCLVATLVTFAVLSSVstiRNQRYHIHANLSFAVLVAQVLLLI-SFRLEPGTTPCQVMAVLLHYFF 615
Cdd:cd15039    3 ILGILTLIGLIISLVFLLLTLAVYALLPEL---RNLHGKCLMCLVLSLFVAYLLLLIgQLLSSGDSTLCVALGILLHFFF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 616 LSAFAWMLVEGLHLY----SMVIKVFGSEDSKHRYYYGM-GWGFPLLICIISL--------SFAMDSYGTsNNCWLSLAS 682
Cdd:cd15039   80 LAAFFWLNVMSFDIWrtfrGKRSSSSRSKERKRFLRYSLyAWGVPLLLVAVTIivdfspntDSLRPGYGE-GSCWISNPW 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 683 GAIWAFVAPALFVIVVNIGILIAVTRVISQISADNYKIHGDPSAFKLTAKAVAVLLPILGTSWVFGVLA-VNGCAVVFQY 761
Cdd:cd15039  159 ALLLYFYGPVALLLLFNIILFILTAIRIRKVKKETAKVQSRLRSDKQRFRLYLKLFVIMGVTWILEIISwFVGGSSVLWY 238
                        250       260       270
                 ....*....|....*....|....*....|.
gi 767973889 762 MFATLNSLQGLFIFLFhCLLNSEVRAAFKHK 792
Cdd:cd15039  239 IFDILNGLQGVFIFLI-FVCKRRVLRLLKKK 268
7tmB1_CRF-R cd15264
corticotropin-releasing factor receptors, member of the class B family of seven-transmembrane ...
536-792 3.98e-35

corticotropin-releasing factor receptors, member of the class B family of seven-transmembrane G protein-coupled receptors; The vertebrate corticotropin-releasing factor (CRF) receptors are predominantly expressed in central nervous system with high levels in cortex tissue, brain stem, and pituitary. They have two isoforms as a result of alternative splicing of the same receptor gene: CRF-R1 and CRF-R2, which differ in tissue distribution and ligand binding affinities. Recently, a third CRF receptor (CRF-R3) has been identified in catfish pituitary. The catfish CRF-R1 is highly homologous to CRF-R3. CRF is a 41-amino acid neuropeptide that plays a central role in coordinating neuroendocrine, behavioral, and autonomic responses to stress by acting as the primary neuroregulator of the hypothalamic-pituitary-adrenal axis, which controls the levels of cortisol and other stress related hormones. In addition, the CRF family of neuropeptides also includes structurally related peptides such as mammalian urocortin, fish urotensin I, and frog sauvagine. The actions of CRF and CRF-related peptides are mediated through specific binding to CRF-R1 and CRF-R2. CRF and urocortin 1 bind and activate mammalian CRF-R1 with similar high affinities. By contrast, urocortin 2 and urocortin 3 do not bind to CRF-R1 or stimulate CRF-R1-mediated cAMP formation. Urocortin 1 also shows high affinity for mammalian CRF-R2, whereas CRF has significantly lower affinity for this receptor. These evidence suggest that urocortin 1 is an endogenous ligand for CRF-R1 and CRF-R2. The CRF receptors are members of the B1 subfamily of class B GPCRs, also referred to as secretin-like receptor family, which includes receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), calcitonin gene-related peptide, and parathyroid hormone (PTH). These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of the B1 subfamily preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. However, depending on its cellular location and function, CRF receptors can activate multiple G proteins, which can in turn stimulate different second messenger pathways.


Pssm-ID: 320392 [Multi-domain]  Cd Length: 265  Bit Score: 134.47  E-value: 3.98e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 536 VALSSISYVGCSLSVLCLVATLVTFAVLSSVSTIRNQryhIHANLSFAVLVAQVLLLISFRLEPGTT------PCQVMAV 609
Cdd:cd15264    2 KVALIIYYLGFSISLVALAVALIIFLYFRSLRCLRNN---IHCNLIVTFILRNVTWFIMQNTLTEIHhqsnqwVCRLIVT 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 610 LLHYFFLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPlliCIISLSFAMDSYGTSN-NCWLSLASGAIWAF 688
Cdd:cd15264   79 VYNYFQVTNFFWMFVEGLYLHTMIVWAYSADKIRFWYYIVIGWCIP---CPFVLAWAIVKLLYENeHCWLPKSENSYYDY 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 689 V--APALFVIVVNIGILIAVTRVISQisadnyKIHGDPSA----FKLTAKAVAVLLPILGTSWVFGVLAVNGCAV---VF 759
Cdd:cd15264  156 IyqGPILLVLLINFIFLFNIVWVLIT------KLRASNTLetiqYRKAVKATLVLLPLLGITYMLFFINPGDDKTsrlVF 229
                        250       260       270
                 ....*....|....*....|....*....|...
gi 767973889 760 QYMFATLNSLQGLFIFLFHCLLNSEVRAAFKHK 792
Cdd:cd15264  230 IYFNTFLQSFQGLFVAVFYCFLNGEVRSAIRKK 262
7tmB2_GPR116_Ig-Hepta cd15254
The immunoglobulin-repeat-containing receptor Ig-hepta/GPR116, member of the class B2 family ...
536-792 2.00e-32

The immunoglobulin-repeat-containing receptor Ig-hepta/GPR116, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR116 (also known as Ig-hepta) is an orphan receptor that belongs to group VI adhesion-GPCRs along with GPR110, GPR111, GPR113, and GPR115. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in ligand recognition as well as cell-cell adhesion and cell-matrix interactions, linked by a stalk region to a class B seven-transmembrane domain. GPR116 has four I-set immunoglobulin-like repeats, which is found in the members of the immunoglobulin superfamily of cell surface proteins, and a SEA (sea urchin sperm protein, enterokinase, and a grin)-box, which is present in the extracellular domain of the transmembrane mucin (MUC) family and known to enhance O-glycosylation. GPR116 is highly expressed in fetal and adult lung, and it has been shown to regulate lung surfactant levels as well as to stimulate breast cancer metastasis through a G(q)-p63-RhoGEF-Rho GTPase signaling pathway. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. However, several adhesion GPCRs, including GPR 111, GPR115, and CELSR1, are predicted to be non-cleavable at the GAIN domain because of the lack of a consensus catalytic triad sequence (His-Leu-Ser/Thr) within their GPS.


Pssm-ID: 320382 [Multi-domain]  Cd Length: 275  Bit Score: 127.23  E-value: 2.00e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 536 VALSSISYVGCSLSVLCLVATLVTFAVLSSVSTIRNQRYHIHA---NLSFAVLVAQVLLLISFRLEPGTTP-----CQVM 607
Cdd:cd15254    2 DELDYITYIGLSISILSLAICIVIESLVWKSVTKNRTSYMRHVcilNIAVSLLIADIWFIVVAAIQDQNYAvngnvCVAA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 608 AVLLHYFFLSAFAWMLVEGLHLYSMVIKVF--GSEDSKHRYYYGMGWGFPLLICIISLSFAM--DSYGTSNNCWLSLA-S 682
Cdd:cd15254   82 TFFIHFFYLCVFFWMLALGLMLFYRLVFILhdTSKTIQKAVAFCLGYGCPLIISVITIAVTLprDSYTRKKVCWLNWEdS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 683 GAIWAFVAPALFVIVVNIGILIAVTRVISQISADNYKIHGDPSAFKLTAKAVAVLLPILGTSWVFGVLAV-NGCAVVFQY 761
Cdd:cd15254  162 KALLAFVIPALIIVAVNSIITVVVIVKILRPSIGEKPSKQERSSLFQIIKSIGVLTPLLGLTWGFGLATViKGSSIVFHI 241
                        250       260       270
                 ....*....|....*....|....*....|.
gi 767973889 762 MFATLNSLQGLFIFLFHCLLNSEVRAAFKHK 792
Cdd:cd15254  242 LFTLLNAFQGLFILVFGTLWDKKVQEALLNK 272
7tmB2_GPR113 cd15253
orphan adhesion receptor GPR113, member of the class B2 family of seven-transmembrane G ...
537-792 3.23e-32

orphan adhesion receptor GPR113, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR113 is an orphan receptor that belongs to group VI adhesion-GPCRs along with GPR110, GPR111, GPR115, and GPR116. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in ligand recognition as well as cell-cell adhesion and cell-matrix interactions, linked by a stalk region to a class B seven-transmembrane domain. GPR113 contains a hormone binding domain and one EGF (epidermal grown factor) domain, and is primarily expressed in a subset of taste receptor cells. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. However, several adhesion GPCRs, including GPR 111, GPR115, and CELSR1, are predicted to be non-cleavable at the GAIN domain because of the lack of a consensus catalytic triad sequence (His-Leu-Ser/Thr) within their GPS.


Pssm-ID: 320381 [Multi-domain]  Cd Length: 271  Bit Score: 126.41  E-value: 3.23e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 537 ALSSISYVGCSLSVLCLVATLVTF-AVLSSVstIRNQ----RYHIHANLSFAVLVAQVLLLISFRLEPGTTP--CQVMAV 609
Cdd:cd15253    3 WLDFLSQVGLGASILALLLCLGIYrLVWRSV--VRNKisyfRHMTLVNIAFSLLLADTCFLGATFLSAGHESplCLAAAF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 610 LLHYFFLSAFAWMLVEGLHLYSMVIKVFgSEDSKHRYYYGM---GWGFPLLICIISLS--FAMDSYGTSNNCWLSLASGA 684
Cdd:cd15253   81 LCHFFYLATFFWMLVQALMLFHQLLFVF-HQLAKRSVLPLMvtlGYLCPLLIAAATVAyyYPKRQYLHEGACWLNGESGA 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 685 IWAFVAPALFVIVVNIGILIAVTRVISQISADNYKIHGDPSAFKLTAKAVAVLLPILGTSWVFGVLAVNG-CAVVFQYMF 763
Cdd:cd15253  160 IYAFSIPVLAIVLVNLLVLFVVLMKLMRPSVSEGPPPEERKALLSIFKALLVLTPVFGLTWGLGVATLTGeSSQVSHYGF 239
                        250       260
                 ....*....|....*....|....*....
gi 767973889 764 ATLNSLQGLFIFLFHCLLNSEVRAAFKHK 792
Cdd:cd15253  240 AILNAFQGVFILLFGCLMDKKVREALLKR 268
7tmB2_GPR126-like_Adhesion_VIII cd15258
orphan GPR126 and related proteins, group VIII adhesion GPCRs, member of the class B2 family ...
537-787 3.61e-32

orphan GPR126 and related proteins, group VIII adhesion GPCRs, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Group VIII adhesion GPCRs include orphan GPCRs such as GPR56, GPR64, GPR97, GPR112, GPR114, and GPR126. GPR56 is involved in the regulation of oligodendrocyte development and myelination in the central nervous system via coupling to G(12/13) proteins, which leads to the activation of RhoA GTPase. GPR126, on the other hand, is required for Schwann cells, but not oligodendrocyte myelination in the peripheral nervous system. Gpr64 is mainly expressed in the epididymis of male reproductive tract, and targeted deletion of GPR64 causes sperm stasis and efferent duct blockage due to abnormal fluid reabsorption, resulting in male infertility. GPR64 is also over-expressed in Ewing's sarcoma (ES), as well as upregulated in other carcinomas from kidney, prostate or lung, and promotes invasiveness and metastasis in ES via the upregulation of placental growth factor (PGF) and matrix metalloproteinase (MMP) 1. GPR97 is identified as a lymphatic adhesion receptor that is specifically expressed in lymphatic endothelium, but not in blood vascular endothelium, and is shown to regulate migration of lymphatic endothelial cells via the small GTPases RhoA and cdc42. GPR112 is specifically expressed in normal enterochromatin cells and gastrointestinal neuroendocrine carcinoma cells, but its biological function is unknown. GPR114 is mainly found in granulocytes (polymorphonuclear leukocytes), and GPR114-transfected cells induced an increase in cAMP levels via coupling to G(s) protein. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320386 [Multi-domain]  Cd Length: 267  Bit Score: 125.99  E-value: 3.61e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 537 ALSSISYVGCSLSVLCLVATLVTFAVLSSVStiRNQRYHIHANLSFAVLvaqvLLLISFRLEPGTTP------CQVMAVL 610
Cdd:cd15258    3 ILTFISYVGCGISAIFLAITILTYIAFRKLR--RDYPSKIHMNLCAALL----LLNLAFLLSSWIASfgsdglCIAVAVA 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 611 LHYFFLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYG-MGWGFPLLICIISLSFAMDSYGTSNN-----------CWL 678
Cdd:cd15258   77 LHYFLLACLTWMGLEAFHLYLLLVKVFNTYIRRYILKLClVGWGLPALLVTLVLSVRSDNYGPITIpngegfqndsfCWI 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 679 SlaSGAIWAFVAPALFVIVVNIGILIAVTrVISQISADNYKIHGDPSAFKLT-AKAVAVLLPILGTSWVFGVLAVNGCAV 757
Cdd:cd15258  157 R--DPVVFYITVVGYFGLTFLFNMVMLAT-VLVQICRLREKAQATPRKRALHdLLTLLGLTFLLGLTWGLAFFAWGPFNL 233
                        250       260       270
                 ....*....|....*....|....*....|
gi 767973889 758 VFQYMFATLNSLQGLFIFLFHCLLNSEVRA 787
Cdd:cd15258  234 PFLYLFAIFNSLQGFFIFIWYCSMKENVRK 263
7tmB2_BAI2 cd15988
brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 ...
544-790 5.14e-32

brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Brain-specific angiogenesis inhibitors (BAI1-3) constitute the group VII of cell-adhesion receptors that have been implicated in vascularization of glioblastomas. They belong to the B2 subfamily of class B GPCRs, are predominantly expressed in the brain, and are only present in vertebrates. Three BAIs, like all adhesion receptors, are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. For example, BAI1 N-terminus contain an integrin-binding RGD (Arg-Gly-Asp) motif in addition to five thrombospondin type 1 repeats (TSRs), which are known to regulate the anti-angiogenic activity of thrombospondin-1, whereas BAI2 and BAI3 have four TSRs, but do not possess RGD motifs. The TSRs are functionally involved in cell attachment, activation of latent TGF-beta, inhibition of angiogenesis and endothelial cell migration. The TSRs of BAI1 mediates direct binding to phosphatidylserine, which enables both recognition and internalization of apoptotic cells by phagocytes. Thus, BAI1 functions as a phosphatidylserine receptor that forms a trimeric complex with ELMO and Dock180, leading to activation of Rac-GTPase which promotes the binding and phagocytosis of apoptotic cells. BAI3 can also interact with the ELMO-Dock180 complex to activate the Rac pathway and can also bind to secreted C1ql proteins of the C1Q complement family via its N-terminal TSRs. BAI3 and its ligands C1QL1 are highly expressed during synaptogenesis and are involved in synapse specificity. Moreover, BAI2 acts as a transcription repressor to regulate vascular endothelial growth factor (VEGF) expression through interaction with GA-binding protein gamma (GABP). The N-terminal extracellular domains of all three BAIs also contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain, which undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif to generate N- and C-terminal fragments (NTF and CTF), a putative hormone-binding domain (HBD), and multiple N-glycosylation sites. The C-terminus of each BAI subtype ends with a conserved Gln-Thr-Glu-Val (QTEV) motif known to interact with PDZ domain-containing proteins, but only BAI1 possesses a proline-rich region, which may be involved in protein-protein interactions.


Pssm-ID: 320654 [Multi-domain]  Cd Length: 291  Bit Score: 126.61  E-value: 5.14e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 544 VGCSLSVLCLVATLVTFAVLSSVstIRNQRYHIHANLSFAVLVAQVLLLISFRLEPGTTPCQVMAVLLHYFFLSAFAWML 623
Cdd:cd15988   10 IGCAVSCMALLILLAIYAAFWRF--IRSERSIILLNFCLSILASNILILVGQSQTLSKGVCTMTAAFLHFFFLSSFCWVL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 624 VEGLHLYSMVIKVFGSEDSKHRYYYgMGWGFPLLICIISLSFA-MDSYGTSNNCWLSLASGAIWAFVAPALFVIVVNIGI 702
Cdd:cd15988   88 TEAWQSYLAVIGRMRTRLVRKRFLC-LGWGLPALVVAVSVGFTrTKGYGTASYCWLSLEGGLLYAFVGPAAVIVLVNMLI 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 703 -LIAVTRVISQ--ISADNYKIH------------------GDPSAFKLTA----KAVA------VLLPILGTSWVFGVLA 751
Cdd:cd15988  167 gIIVFNKLMSRdgISDKSKKQRagseaepcsslllkcskcGVVSSAAMSSatasSAMAslwsscVVLPLLALTWMSAVLA 246
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 767973889 752 V-NGCAVVFQYMFATLNSLQGLFIFLFHCLLNSEVRAAFK 790
Cdd:cd15988  247 MtDRRSILFQVLFAVFNSVQGFVIITVHCFLRREVQDVVK 286
7tmB2_BAI1 cd15990
brain-specific angiogenesis inhibitor 1, a group VII adhesion GPCR, member of the class B2 ...
544-790 7.76e-31

brain-specific angiogenesis inhibitor 1, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Brain-specific angiogenesis inhibitors (BAI1-3) constitute the group VII of cell-adhesion receptors that have been implicated in vascularization of glioblastomas. They belong to the B2 subfamily of class B GPCRs, are predominantly expressed in the brain, and are only present in vertebrates. Three BAIs, like all adhesion receptors, are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. For example, BAI1 N-terminus contain an integrin-binding RGD (Arg-Gly-Asp) motif in addition to five thrombospondin type 1 repeats (TSRs), which are known to regulate the anti-angiogenic activity of thrombospondin-1, whereas BAI2 and BAI3 have four TSRs, but do not possess RGD motifs. The TSRs are functionally involved in cell attachment, activation of latent TGF-beta, inhibition of angiogenesis and endothelial cell migration. The TSRs of BAI1 mediates direct binding to phosphatidylserine, which enables both recognition and internalization of apoptotic cells by phagocytes. Thus, BAI1 functions as a phosphatidylserine receptor that forms a trimeric complex with ELMO and Dock180, leading to activation of Rac-GTPase which promotes the binding and phagocytosis of apoptotic cells. BAI3 can also interact with the ELMO-Dock180 complex to activate the Rac pathway and can also bind to secreted C1ql proteins of the C1Q complement family via its N-terminal TSRs. BAI3 and its ligands C1QL1 are highly expressed during synaptogenesis and are involved in synapse specificity. Moreover, BAI2 acts as a transcription repressor to regulate vascular endothelial growth factor (VEGF) expression through interaction with GA-binding protein gamma (GABP). The N-terminal extracellular domains of all three BAIs also contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain, which undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif to generate N- and C-terminal fragments (NTF and CTF), a putative hormone-binding domain (HBD), and multiple N-glycosylation sites. The C-terminus of each BAI subtype ends with a conserved Gln-Thr-Glu-Val (QTEV) motif known to interact with PDZ domain-containing proteins, but only BAI1 possesses a proline-rich region, which may be involved in protein-protein interactions.


Pssm-ID: 320656  Cd Length: 267  Bit Score: 122.41  E-value: 7.76e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 544 VGCSLSVLCLVATLVTFavLSSVSTIRNQRYHIHANLSFAVLVAQVLLLISFRLEPGTTPCQVMAVLLHYFFLSAFAWML 623
Cdd:cd15990   13 VGCGVSSLTLLLLIIIY--VSVWRYIRSERSVILINFCLSIISSNALILIGQTQTRNKVVCTLVAAFLHFFFLSSFCWVL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 624 VEGLHLYSMVIKVFGSEDSKHRYYYgMGWGFPLLICIISLSFA-MDSYGTSNNCWLSLASGAIWAFVAPALFVIVVN--I 700
Cdd:cd15990   91 TEAWQSYMAVTGRLRNRIIRKRFLC-LGWGLPALVVAISVGFTkAKGYGTVNYCWLSLEGGLLYAFVGPAAAVVLVNmvI 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 701 GILIaVTRVISQISADNYKIHGDPSAfklTAKAVAVLLPILGTSWVFGVLAV-NGCAVVFQYMFATLNSLQGLFIFLFHC 779
Cdd:cd15990  170 GILV-FNKLVSKDGITDKKLKERAGA---SLWSSCVVLPLLALTWMSAVLAItDRRSALFQILFAVFDSLEGFVIVMVHC 245
                        250
                 ....*....|.
gi 767973889 780 LLNSEVRAAFK 790
Cdd:cd15990  246 ILRREVQDAVK 256
7tmB2_GPR124-like_Adhesion_III cd15259
orphan GPR124 and related proteins, group III adhesion GPCRs, member of class B2 family of ...
538-790 3.86e-30

orphan GPR124 and related proteins, group III adhesion GPCRs, member of class B2 family of seven-transmembrane G protein-coupled receptors; group III adhesion GPCRs include orphan GPR123, GPR124, GPR125, and their closely related proteins. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. GPR123 is predominantly expressed in the CNS including thalamus, brain stem and regions containing large pyramidal cells. GPR124, also known as tumor endothelial marker 5 (TEM5), is highly expressed in tumor vessels and in the vasculature of the developing embryo. GPR124 is essentially required for proper angiogenic sprouting into neural tissue, CNS-specific vascularization, and formation of the blood-brain barrier. GPR124 also interacts with the PDZ domain of DLG1 (discs large homolog 1) through its PDZ-binding motif. Recently, studies of double-knockout mice showed that GPR124 functions as a co-activator of Wnt7a/Wnt7b-dependent beta-catenin signaling in brain endothelium. Furthermore, WNT7-stimulated beta-catenin signaling is regulated by GPR124's intracellular PDZ binding motif and leucine-rich repeats (LRR) in its N-terminal extracellular domain. GPR125 directly interacts with dishevelled (Dvl) via its intracellular C-terminus, and together, GPR125 and Dvl recruit a subset of planar cell polarity (PCP) components into membrane subdomains, a prerequisite for activation of Wnt/PCP signaling. Thus, GPR125 influences the noncanonical WNT/PCP pathway, which does not involve beta-catenin, through interacting with and modulating the distribution of Dvl.


Pssm-ID: 320387 [Multi-domain]  Cd Length: 260  Bit Score: 120.17  E-value: 3.86e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 538 LSSISYVGCSLSVLCLVATLVTFAVLSSVSTIRNQRYHIHANLSFAVLVAQVLLLISFRLEPGTTPCQVMAVLLHYFFLS 617
Cdd:cd15259    4 LHPVVYAGAALCLLCLLATIITYIVFHRLIRISRKGRHMLVNLCLHLLLTCVVFVGGINRTANQLVCQAVGILLHYSTLC 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 618 AFAWMLVEGLHLYSMVIKVFGS---EDSKHR------YYYGMGWGFPLLICIISLSFAMDSYGTSNNCWLSlASGAIWAF 688
Cdd:cd15259   84 TLLWVGVTARNMYKQVTKTAKPpqdEDQPPRppkpmlRFYLIGWGIPLIICGITAAVNLDNYSTYDYCWLA-WDPSLGAF 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 689 VAPALFVIVVNIGILIAVtrvisqisadNYKIHGDPSAFKLTAKAVAVLLPILGTSWVFGVLAVNGCA---VVFQYMFAT 765
Cdd:cd15259  163 YGPAALIVLVNCIYFLRI----------YCQLKGAPVSFQSQLRGAVITLFLYVAMWACGALAVSQRYfldLVFSCLYGA 232
                        250       260
                 ....*....|....*....|....*
gi 767973889 766 LNSLQGLFIFLFHCLLNSEVRAAFK 790
Cdd:cd15259  233 TCSSLGLFVLIHHCLSREDVRQSWR 257
7tmB1_NPR_B4_insect-like cd15260
insect neuropeptide receptor subgroup B4 and related proteins, member of the class B family of ...
540-792 6.70e-29

insect neuropeptide receptor subgroup B4 and related proteins, member of the class B family of seven-transmembrane G protein-coupled receptors; This subgroup includes a neuropeptide receptor found in Nilaparvata lugens (brown planthopper) and its closely related proteins from mollusks and annelid worms. They belong to the B1 subfamily of class B GPCRs, also referred to as secretin-like receptor family, which includes receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), calcitonin gene-related peptide, parathyroid hormone (PTH), and corticotropin-releasing factor. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of the B1 subfamily preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. The class B GPCRs have been identified in all the vertebrates, from fishes to mammals, as well as invertebrates including Caenorhabditis elegans and Drosophila melanogaster, but are not present in plants, fungi, or prokaryotes.


Pssm-ID: 320388 [Multi-domain]  Cd Length: 267  Bit Score: 116.60  E-value: 6.70e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 540 SISYVGCSLSvlcLVATLVTFAVLSSVSTIRNQRYHIHANLSFAVLVAQVLLLISFRL---EPGTTP-----CQVMAVLL 611
Cdd:cd15260    6 YVYIGGYSVS---LIALIISLAIFFSFRSLRCTRITIHMNLFISFALNNLLWIVWYKLvvdNPEVLLenpiwCQALHVLL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 612 HYFFLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLICIISLSFAMDSYGTSNNCWLSlASGAIWAFVAP 691
Cdd:cd15260   83 QYFMVCNYFWMFCEGLYLHTVLVVAFISEKSLMRWFIAIGWGVPLVITAIYAGVRASLPDDTERCWME-ESSYQWILIVP 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 692 ALFVIVVNIGILIAVTRVI----SQISAdnykiHGDPSAFKLTAKAVAVLLPILGTSWVFGVLAVNGCAV---VFQYMFA 764
Cdd:cd15260  162 VVLSLLINLIFLINIVRVLltklRATSP-----NPAPAGLRKAVRATLILIPLLGLQFLLIPFRPEPGAPletIYQYVSA 236
                        250       260
                 ....*....|....*....|....*...
gi 767973889 765 TLNSLQGLFIFLFHCLLNSEVRAAFKHK 792
Cdd:cd15260  237 LLTSLQGLCVAVLFCFCNGEVIAAIKRK 264
7tmB2_GPR114 cd15443
orphan adhesion receptor GPR114, member of the class B2 family of seven-transmembrane G ...
538-793 2.77e-28

orphan adhesion receptor GPR114, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR114 is an orphan receptor that has been classified as that belongs to the Group VIII of adhesion GPCRs. Other members of the Group VII include GPR56, GPR64, GPR97, GPR112, and GPR126. GPR114 is mainly found in granulocytes (polymorphonuclear leukocytes), and GPR114-transfected cells induced an increase in cAMP levels via coupling to G(s) protein. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320559 [Multi-domain]  Cd Length: 268  Bit Score: 114.85  E-value: 2.77e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 538 LSSISYVGCSLSVlclVATLVTfAVLSSVSTIRNQRY--HIHANLSFAVLVAQVLLLIS--FRLEPGTTPCQVMAVLLHY 613
Cdd:cd15443    4 LTYISIVGCSISA---AASLLT-ILLHFFSRKQPKDSttRIHMNLLGSLFLLNGSFLLSppLATSQSTWLCRAAAALLHY 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 614 FFLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGM-GWGFPLLICIISLSFAMDSYG-----------TSNNCWLSLA 681
Cdd:cd15443   80 SLLCCLTWMAIEGFHLYLLLVKVYNIYIRRYVLKLCVlGWGLPALIVLLVLIFKREAYGphtiptgtgyqNASMCWITSS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 682 SGAIWAFVAPALFVIVVNIGILIAVTRVISQISADNYKIHGDPSAFKLTAKAVAVLlpiLGTSWVFGVLAVnGCAVVFQ- 760
Cdd:cd15443  160 KVHYVLVLGYAGLTSLFNLVVLAWVVRMLRRLRSRKQELGERARRDWVTVLGLTCL---LGTTWALAFFSF-GVFLIPQl 235
                        250       260       270
                 ....*....|....*....|....*....|...
gi 767973889 761 YMFATLNSLQGLFIFLFHCLLNSEVRAAFKHKT 793
Cdd:cd15443  236 FLFTIINSLYGFFICLWYCTQRRRSDASAKSST 268
7tmB2_BAI3 cd15989
brain-specific angiogenesis inhibitor 3, a group VII adhesion GPCR, member of the class B2 ...
544-794 2.62e-27

brain-specific angiogenesis inhibitor 3, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Brain-specific angiogenesis inhibitors (BAI1-3) constitute the group VII of cell-adhesion receptors that have been implicated in vascularization of glioblastomas. They belong to the B2 subfamily of class B GPCRs, are predominantly expressed in the brain, and are only present in vertebrates. Three BAIs, like all adhesion receptors, are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. For example, BAI1 N-terminus contain an integrin-binding RGD (Arg-Gly-Asp) motif in addition to five thrombospondin type 1 repeats (TSRs), which are known to regulate the anti-angiogenic activity of thrombospondin-1, whereas BAI2 and BAI3 have four TSRs, but do not possess RGD motifs. The TSRs are functionally involved in cell attachment, activation of latent TGF-beta, inhibition of angiogenesis and endothelial cell migration. The TSRs of BAI1 mediates direct binding to phosphatidylserine, which enables both recognition and internalization of apoptotic cells by phagocytes. Thus, BAI1 functions as a phosphatidylserine receptor that forms a trimeric complex with ELMO and Dock180, leading to activation of Rac-GTPase which promotes the binding and phagocytosis of apoptotic cells. BAI3 can also interact with the ELMO-Dock180 complex to activate the Rac pathway and can also bind to secreted C1ql proteins of the C1Q complement family via its N-terminal TSRs. BAI3 and its ligands C1QL1 are highly expressed during synaptogenesis and are involved in synapse specificity. Moreover, BAI2 acts as a transcription repressor to regulate vascular endothelial growth factor (VEGF) expression through interaction with GA-binding protein gamma (GABP). The N-terminal extracellular domains of all three BAIs also contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain, which undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif to generate N- and C-terminal fragments (NTF and CTF), a putative hormone-binding domain (HBD), and multiple N-glycosylation sites. The C-terminus of each BAI subtype ends with a conserved Gln-Thr-Glu-Val (QTEV) motif known to interact with PDZ domain-containing proteins, but only BAI1 possesses a proline-rich region, which may be involved in protein-protein interactions.


Pssm-ID: 320655 [Multi-domain]  Cd Length: 293  Bit Score: 112.86  E-value: 2.62e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 544 VGCSLSVLCLVATLVTFAVLSSVstIRNQRYHIHANLSFAVLVAQVLLLISFRLEPGTTPCQVMAVLLHYFFLSAFAWML 623
Cdd:cd15989   12 VGCGLSCLALITLAVVYAALWRY--IRSERSIILINFCLSIISSNILILVGQTQTHNKGICTMTTAFLHFFFLASFCWVL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 624 VEGLHLYSMVIKVFGSEDSKHRYYYgMGWGFPLLICIISLSFA-MDSYGTSNNCWLSLASGAIWAFVAPALFVIVVN--I 700
Cdd:cd15989   90 TEAWQSYMAVTGKIRTRLIRKRFLC-LGWGLPALVVAISMGFTkAKGYGTPHYCWLSLEGGLLYAFVGPAAAVVLVNmvI 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 701 GILIaVTRVISQISADNYKIH--------------------GDPSAFKLTAKAVA----------VLLPILGTSWVFGVL 750
Cdd:cd15989  169 GILV-FNKLVSRDGILDKKLKhragqmsephsgltlkcakcGVVSTTALSATTASnamaslwsscVVLPLLALTWMSAVL 247
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 767973889 751 AV-NGCAVVFQYMFATLNSLQGLFIFLFHCLLNSEVRAAFKHKTK 794
Cdd:cd15989  248 AMtDKRSILFQILFAVFDSLQGFVIVMVHCILRREVQDAFRCRLR 292
7tmB2_GPR126 cd15996
orphan adhesion receptor GPR126, member of the class B2 family of seven-transmembrane G ...
538-790 4.25e-27

orphan adhesion receptor GPR126, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR126 is an orphan receptor that has been classified as that belongs to the Group VIII of adhesion GPCRs. Other members of the Group VII include orphan GPCRs such as GPR56, GPR64, GPR97, GPR112, and GPR114. GPR126 is required in Schwann cells for proper differentiation and myelination via G-Protein Activation. GPR126 is believed to couple to G(s)-protein, which leads to activation of adenylate cyclase for cAMP production. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320662  Cd Length: 271  Bit Score: 111.52  E-value: 4.25e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 538 LSSISYVGCSLSVLCLVATLVTFAVLSSVStiRNQRYHIHANLSFAVLVAQVLLLI-----SFRLEpgtTPCQVMAVLLH 612
Cdd:cd15996    4 LTFITYIGCGISAIFSAATLLTYIAFEKLR--RDYPSKILMNLSTALLFLNLVFLLdgwiaSFEID---ELCITVAVLLH 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 613 YFFLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGM-GWGFPLLICIISLSFAMDSY------------GTSNNCWLS 679
Cdd:cd15996   79 FFLLATFTWMGLEAIHMYIALVKVFNTYIRRYILKFCIiGWGLPALIVSIVLASTNDNYgygyygkdkdgqGGDEFCWIK 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 680 laSGAIWAFVAPALFVIV--VNIGILIAVtrvISQISADNYKIHGDPSAFKL--TAKAVAVLLPILGTSWVFGVLAVNGC 755
Cdd:cd15996  159 --NPVVFYVTCAAYFGIMflMNVAMFIVV---MVQICGRNGKRSNRTLREEIlrNLRSVVSLTFLLGMTWGFAFFAWGPV 233
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 767973889 756 AVVFQYMFATLNSLQGLFIFLFHCLLNSEVRAAFK 790
Cdd:cd15996  234 NLAFMYLFTIFNSLQGLFIFVFHCALKENVQKQWR 268
7tmB2_GPR64 cd15444
orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B ...
536-790 4.93e-27

orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors; GPR64 is an orphan receptor that has been classified as that belongs to the Group VIII of adhesion GPCRs. Other members of the Group VII include orphan GPCRs such as GPR56, GPR97, GPR112, GPR114, and GPR126. GPR64 is mainly expressed in the epididymis of male reproductive tract, and targeted deletion of GPR64 causes sperm stasis and efferent duct blockage due to abnormal fluid reabsorption, resulting in male infertility. GPR64 is also over-expressed in Ewing's sarcoma (ES), as well as upregulated in other carcinomas from kidney, prostate or lung, and promotes invasiveness and metastasis in ES via the upregulation of placental growth factor (PGF) and matrix metalloproteinase (MMP) 1. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320560 [Multi-domain]  Cd Length: 271  Bit Score: 111.46  E-value: 4.93e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 536 VALSSISYVGCSLSVLCLVATLVTFAVLSSVStiRNQRYHIHANLSFAVLVAQVLLLIS-----FRLEPGTtpCQVMAVL 610
Cdd:cd15444    2 LILTFITYIGCGLSAIFLSVTLVTYIAFEKIR--RDYPSKILIQLCVALLLLNLVFLLDswialYKDIVGL--CISVAVF 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 611 LHYFFLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGM-GWGFPLLICIISLSFAMDSYG-----------TSNNCWL 678
Cdd:cd15444   78 LHYFLLVSFTWMGLEAFHMYLALVKVFNTYIRKYILKFCIvGWGVPAVVVAIVLAVSKDNYGlgsygkspngsTDDFCWI 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 679 SLASGAIWAFVAPALFVIVVNIGILIAVTRVISQISADnyKIHGDPSAFKLT-AKAVAVLLPILGTSWVFGVLAVNGCAV 757
Cdd:cd15444  158 NNNIVFYITVVGYFCVIFLLNISMFIVVLVQLCRIKKQ--KQLGAQRKTSLQdLRSVAGITFLLGITWGFAFFAWGPVNL 235
                        250       260       270
                 ....*....|....*....|....*....|...
gi 767973889 758 VFQYMFATLNSLQGLFIFLFHCLLNSEVRAAFK 790
Cdd:cd15444  236 AFMYLFAIFNTLQGFFIFIFYCVAKENVRKQWR 268
7tmB1_GlucagonR-like cd15929
glucagon receptor-like subfamily, member of the class B family of seven-transmembrane G ...
544-792 2.00e-25

glucagon receptor-like subfamily, member of the class B family of seven-transmembrane G protein-coupled receptors; This group represents the glucagon receptor family of G protein-coupled receptors, which includes glucagon receptor (GCGR), glucagon-like peptide-1 receptor (GLP1R), GLP2R, and closely related receptors. These receptors are activated by the members of the glucagon (GCG) peptide family including GCG, glucagon-like peptide 1 (GLP1), and GLP2, which are derived from the large proglucagon precursor. GCGR regulates blood glucose levels by control of hepatic glycogenolysis and gluconeogenesis and by regulation of insulin secretion from the pancreatic beta-cells. Activation of GLP1R stimulates glucose-dependent insulin secretion from pancreatic beta cells, whereas activation of GLP2R stimulates intestinal epithelial proliferation and increases villus height in the small intestine. Receptors in this group belong to the B1 (or secretin-like) subfamily of class B GPCRs, which includes receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, calcitonin gene-related peptide, parathyroid hormone (PTH), and corticotropin-releasing factor. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of the B1 subfamily preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. However, depending on their cellular location, GCGR and GLP receptors can activate multiple G proteins, which can in turn stimulate different second messenger pathways.


Pssm-ID: 341353 [Multi-domain]  Cd Length: 279  Bit Score: 106.75  E-value: 2.00e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 544 VGCSLSVLCLVATLvtfAVLSSVSTIRNQRYHIHANL--SF-----AVLVAQVLLLISFRLEPG------------TTPC 604
Cdd:cd15929   10 VGYSLSLAALVLAL---AILLGLRKLHCTRNYIHANLfaSFilralSVLVKDALLPRRYSQKGDqdlwstllsnqaSLGC 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 605 QVMAVLLHYFFLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLIcIISLSFAMDSYGTSnNCWLSLASGA 684
Cdd:cd15929   87 RVAQVLMQYCVAANYYWLLVEGLYLHTLLVLAVFSERSIFRLYLLLGWGAPVLF-VVPWGIVKYLYENT-GCWTRNDNMA 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 685 IWAFV-APALFVIVVNIGILIAVTR-VISQISAdNYKIHGDpSAFKLtAKAVAVLLPILGTSWVFGVLAVNGCA---VVF 759
Cdd:cd15929  165 YWWIIrLPILLAILINFFIFVRILKiLVSKLRA-NQMCKTD-YKFRL-AKSTLTLIPLLGVHEVVFAFVTDEQArgtLRF 241
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 767973889 760 QYMFATL--NSLQGLFIFLFHCLLNSEVRAAFKHK 792
Cdd:cd15929  242 IKLFFELflSSFQGLLVAVLYCFANKEVQSELRKK 276
7tmB2_GPR111_115 cd15994
orphan adhesion receptors GPR111 and GPR115, member of the class B2 family of ...
538-790 2.97e-25

orphan adhesion receptors GPR111 and GPR115, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR111 and GPR115 are highly homologous orphan receptors that belong to group VI adhesion-GPCRs along with GPR110, GPR113, and GPR116. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in ligand recognition as well as cell-cell adhesion and cell-matrix interactions, linked by a stalk region to a class B seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. However, several adhesion GPCRs, including GPR 111, GPR115, and CELSR1, are predicted to be non-cleavable at the GAIN domain because of the lack of a consensus catalytic triad sequence (His-Leu-Ser/Thr) within their GPS. Both GPR111 and GPR5 are present only in land-living animals and are predominantly expressed in the developing skin.


Pssm-ID: 320660 [Multi-domain]  Cd Length: 267  Bit Score: 106.08  E-value: 2.97e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 538 LSSISYVGCSLSVLCLVATLVTFAVLSSVSTIRNQRYHIH---ANLSFAVLVAQVLLLISFRLEPGTTP---CQVMAVLL 611
Cdd:cd15994    4 LDYITRIGLGLSIFSLALCLTIEAVVWSHVTKTEITYMRHvciVNIATSLLIADVWFILASIVHNTALNyplCVAATFFL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 612 HYFFLSAFAWMLVEGLH-LYSMVIKVFGSEDSKH-RYYYGMGWGFPLLICIISLSFA--MDSYGTSNNCWLSL-ASGAIW 686
Cdd:cd15994   84 HFFYLSLFFWMLTKALLiLYGILLVFFKITKSVFiATAFSIGYGCPLVIAVLTVAITepKKGYLRPEACWLNWdETKALL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 687 AFVAPALFVIVVNIgILIAVTRVISQISADNYKIHGDPSAFKLTAKAVAVLLPILGTSWVFGVLA-VNGCAVVFQYMFAT 765
Cdd:cd15994  164 AFIIPALSIVVVNL-IVVGVVVVKTQRSSIGESCKQDVSNIIRISKNVAILTPLLGLTWGFGLATiIDSRSLPFHIIFAL 242
                        250       260
                 ....*....|....*....|....*
gi 767973889 766 LNSLQGLFIFLFHCLLNSEVRAAFK 790
Cdd:cd15994  243 LNAFQGFFILLFGTILDRKIRIALY 267
7tmB1_PDFR cd15261
The pigment dispersing factor receptor, member of the class B seven-transmembrane G ...
541-790 4.67e-25

The pigment dispersing factor receptor, member of the class B seven-transmembrane G protein-coupled receptors; The pigment dispersing factor receptor (PDFR) is a G protein-coupled receptor that binds the circadian clock neuropeptide PDF, a functional ortholog of the mammalian vasoactive intestinal peptide (VIP), on the pacemaker neurons. The PDFR is implicated in regulating flight circuit development and in modulating acute flight In Drosophila melanogaster. The PDFR activation stimulates adenylate cyclase, thereby increasing cAMP levels in many different pacemakers, and the receptor signaling has been shown to regulate behavioral circadian rhythms and geotaxis in Drosophila. The PDFR belongs to the B1 subfamily of class B GPCRs, also referred to as secretin-like receptor family, which includes receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), calcitonin gene-related peptide, parathyroid hormone (PTH), and corticotropin-releasing factor. . These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of the B1 subfamily preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. They play key roles in hormone homeostasis in mammals and are promising drug targets in various human diseases including diabetes, osteoporosis, obesity, neurodegenerative conditions (Alzheimer###s and Parkinson's), cardiovascular disease, migraine, and psychiatric disorders (anxiety, depression).


Pssm-ID: 320389 [Multi-domain]  Cd Length: 282  Bit Score: 105.91  E-value: 4.67e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 541 ISYVGCSLSVLCLVATLVTFAVLSSVstiRNQRYHIHANLSFAVLVAQVLLLI-----SFRLEPGT-------------- 601
Cdd:cd15261    7 LEIVGLCLSLVSLIISLFIFSYFRTL---RNHRTRIHKNLFLAILLQVIIRLVlyidqAITRSRGShtnaattegrtins 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 602 TP--CQVMAVLLHYFFLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLICIISLSFAMDSYGTsNNCWLS 679
Cdd:cd15261   84 TPilCEGFYVLLEYAKTVMFMWMFIEGLYLHNIIVVSVFSGKPNYLFYYILGWGIPIVHTSAWAIVTLIKMKV-NRCWFG 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 680 LA-SGAIWAFVAPALFVIVVNIGILIAVTRV-ISQISADNykihgDPSAFKL--TAKAVAVLLPILGTSWVFGVLAVNGC 755
Cdd:cd15261  163 YYlTPYYWILEGPRLAVILINLFFLLNIIRVlVSKLRESH-----SREIEQVrkAVKAAIVLLPLLGITNILQMIPPPLT 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 767973889 756 AVVFQ-----YMFATLNSLQGLFIFLFHCLLNSEVRAAFK 790
Cdd:cd15261  238 SVIVGfavwsYSTHFLTSFQGFFVALIYCFLNGEVKNVLK 277
7tmB1_GLP2R cd15266
glucagon-like peptide-2 receptor, member of the class B family of seven-transmembrane G ...
535-798 4.03e-23

glucagon-like peptide-2 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors; Glucagon-like peptide-2 receptor (GLP2R) is a member of the glucagon receptor family of G protein-coupled receptors, which also includes glucagon receptor (GCGR) and GLP1R. GLP2R is activated by glucagon-like peptide 2, which is derived from the large proglucagon precursor. Activation of GLP1R stimulates glucose-dependent insulin secretion from pancreatic beta cells, whereas activation of GLP2R stimulates intestinal epithelial proliferation and increases villus height in the small intestine. GCGR regulates blood glucose levels by control of hepatic glycogenolysis and gluconeogenesis and by regulation of insulin secretion from the pancreatic beta-cells. GLP2R belongs to the B1 (or secretin-like) subfamily of class B GPCRs, which includes receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, calcitonin gene-related peptide, parathyroid hormone (PTH), and corticotropin-releasing factor. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of the B1 subfamily preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. However, depending on their cellular location, GCGR and GLP receptors can activate multiple G proteins, which can in turn stimulate different second messenger pathways.


Pssm-ID: 320394 [Multi-domain]  Cd Length: 280  Bit Score: 100.20  E-value: 4.03e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 535 QVALSSISYVGCSLSVLCLVATLVTFAVLSSVSTIRNqryHIHANL--SF-----AVLVAQVLL-------------LIS 594
Cdd:cd15266    1 LLTLQLIYTIGYSLSLISLSLALLILLLLRKLHCTRN---YIHMNLfaSFilralAVLIKDIVLystyskrpddetgWIS 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 595 FRLEPGTTPCQVMAVLLHYFFLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLIcIISLSFAmDSYGTSN 674
Cdd:cd15266   78 YLSEESSTSCRVAQVFMHYFVGANYFWLLVEGLYLHTLLVTAVLSERRLLKKYMLIGWGTPVLF-VVPWGVA-KILLENT 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 675 NCWLSLASGAIWAFV-APALFVIVVNIGILIAVTR-VISQISADNYKIHGdpSAFKLtAKAVAVLLPILGT-SWVFGVLA 751
Cdd:cd15266  156 GCWGRNENMGIWWIIrGPILLCITVNFYIFLKILKlLLSKLKAQQMRFTD--YKYRL-ARSTLVLIPLLGIhEVVFSFIT 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767973889 752 ---VNGCAVVFQ-YMFATLNSLQGLFIFLFHCLLNSEVRAAFKhktKVWSL 798
Cdd:cd15266  233 deqVEGFSRHIRlFIQLTLSSFQGFLVAVLYCFANGEVKAELK---KRWQL 280
7tmB1_Secretin_R-like cd15930
secretin receptor-like group of hormone receptors, member of the class B family of ...
544-792 6.85e-22

secretin receptor-like group of hormone receptors, member of the class B family of seven-transmembrane G protein-coupled receptors; This group represents G protein-coupled receptors for structurally similar peptide hormones that include secretin, growth-hormone-releasing hormone (GHRH), pituitary adenylate cyclase activating polypeptide (PACAP), and vasoactive intestinal peptide (VIP). These receptors are classified into the subfamily B1 of class B GRCRs that consists of the classical hormone receptors and have been identified in all the vertebrates, from fishes to mammals, but are not present in plants, fungi, or prokaryotes. For all class B receptors, the large N-terminal extracellular domain plays a critical role in peptide hormone recognition. Secretin, a polypeptide secreted by entero-endocrine S cells in the small intestine, is involved in maintaining body fluid balance. This polypeptide regulates the secretion of bile and bicarbonate into the duodenum from the pancreatic and biliary ducts, as well as regulates the duodenal pH by the control of gastric acid secretion. Studies with secretin receptor-null mice indicate that secretin plays a role in regulating renal water reabsorption. Secretin mediates its biological actions by elevating intracellular cAMP via G protein-coupled secretin receptors, which are expressed in the brain, pancreas, stomach, kidney, and liver. GHRHR is a specific receptor for the growth hormone-releasing hormone (GHRH) that controls the synthesis and release of growth hormone (GH) from the anterior pituitary somatotrophs. Mutations in the gene encoding GHRHR have been connected to isolated growth hormone deficiency (IGHD), a short-stature condition caused by deficient production of GH or lack of GH action. VIP and PACAP exert their effects through three G protein-coupled receptors, PACAP-R1, VIP-R1 (vasoactive intestinal receptor type 1, also known as VPAC1) and VIP-R2 (or VPAC2). PACAP-R1 binds only PACAP with high affinity, whereas VIP-R1 and -R2 specifically bind and respond to both VIP and PACAP. VIP and PACAP and their receptors are widely expressed in the brain and periphery. They are upregulated in neurons and immune cells in responses to CNS injury and/or inflammation and exert potent anti-inflammatory effects, as well as play important roles in the control of circadian rhythms and stress responses, among many others. All B1 subfamily GPCRs are able to increase intracellular cAMP levels by coupling to adenylate cyclase via a stimulatory Gs protein. However, depending on its cellular location, some members of subfamily B1 are also capable of coupling to additional G proteins such as G(i/o) and/or G(q) proteins, thereby leading to activation of phospholipase C and intracellular calcium influx.


Pssm-ID: 320596 [Multi-domain]  Cd Length: 268  Bit Score: 96.35  E-value: 6.85e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 544 VGCSLSVLCLVATLVTFAVLSSVSTIRNQrYHIHANLSF-----AVLVAQVLLLISFRLE---PGTTPCQVMAVLLHYFF 615
Cdd:cd15930   10 VGYSLSLTSLTTAMIILCLFRKLHCTRNY-IHMNLFVSFilraiAVFIKDAVLFSSEDVDhcfVSTVGCKASMVFFQYCV 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 616 LSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLicIISLSFAMDSYGTSNNCWLSLASGAIWAFV-APALF 694
Cdd:cd15930   89 MANFFWLLVEGLYLHTLLVISFFSERRYFWWYVLIGWGAPTV--FVTVWIVARLYFEDTGCWDINDESPYWWIIkGPILI 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 695 VIVVNIGILIAVTRVISQISADNYKIHGDPSAFKLTAKAVAVLLPILGTSW-VFGVLAVNGCAVVFQYMFATLNSLQGLF 773
Cdd:cd15930  167 SILVNFVLFINIIRILLQKLRSPDIGGNESSQYKRLARSTLLLIPLFGIHYiVFAFFPENISLGIRLYFELCLGSFQGFV 246
                        250
                 ....*....|....*....
gi 767973889 774 IFLFHCLLNSEVRAAFKHK 792
Cdd:cd15930  247 VAVLYCFLNGEVQAEIKRK 265
7tmB1_GHRHR2 cd15271
growth-hormone-releasing hormone receptor type 2, member of the class B family of ...
544-790 1.08e-21

growth-hormone-releasing hormone receptor type 2, member of the class B family of seven-transmembrane G protein-coupled receptors; Growth hormone-releasing hormone receptor type 2 (GHRHR2) is found in non-mammalian vertebrates such as chicken and frog. It is a member of the group of G protein-coupled receptors for structurally similar peptide hormones that also include secretin, pituitary adenylate cyclase activating polypeptide (PACAP), vasoactive intestinal peptide, and mammalian growth hormone-releasing hormone. These receptors are classified into the subfamily B1 of class B GRCRs that consists of the classical hormone receptors and have been identified in all the vertebrates, from fishes to mammals, but are not present in plants, fungi, or prokaryotes. For all class B receptors, the large N-terminal extracellular domain plays a critical role in peptide hormone recognition. Mammalian GHRHR is a specific receptor for the growth hormone-releasing hormone (GHRH) that controls the synthesis and release of growth hormone (GH) from the anterior pituitary somatotrophs. Mutations in the gene encoding GHRHR have been connected to isolated growth hormone deficiency (IGHD), a short-stature condition caused by deficient production of GH or lack of GH action. Mammalian GHRH is preferentially coupled to a stimulatory G(s) protein, which leads to the activation of adenylate cyclase and thereby increases in intracellular cAMP level. GHRHR is found in mammals as well as zebrafish and chicken, whereas the GHRHR type 2, an ortholog of the GHRHR, has only been identified in ray-finned fish, chicken and Xenopus. Xenopus laevis GHRHR2 has been shown to interact with both endogenous GHRH and PACAP-related peptide (PRP).


Pssm-ID: 320399 [Multi-domain]  Cd Length: 267  Bit Score: 95.57  E-value: 1.08e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 544 VGCSLSVLCLVATLVTFAVLSSVSTIRNqryHIHANL--SF-----AVLVAQVLLLISFRLEP---GTTPCQVMAVLLHY 613
Cdd:cd15271   10 VGYGTSLTSLITAVLIFCTFRKLHCTRN---YIHINLfvSFilralAVFIKDAVLFADESVDHctmSTVACKAAVTFFQF 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 614 FFLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLICII--SLSFAMDSYGtsnnCWLSLASGAIWAFVAP 691
Cdd:cd15271   87 CVLANFFWLLVEGMYLQTLLLLTFTSDRKYFWWYILIGWGAPSVTVTVwvLTRLQYDNRG----CWDDLESRIWWIIKTP 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 692 ALFVIVVNIGILIAVTRVISQISADNYKIHGDPSAFKLTAKAVAVLLPILGTSW-VFGVLAVNGCAVVFQYMFATLNSLQ 770
Cdd:cd15271  163 ILLSVFVNFLIFINVIRILVQKLKSPDVGGNDTSHYMRLAKSTLLLIPLFGVHYvVFAFFPEHVGVEARLYFELVLGSFQ 242
                        250       260
                 ....*....|....*....|
gi 767973889 771 GLFIFLFHCLLNSEVRAAFK 790
Cdd:cd15271  243 GFIVALLYCFLNGEVQAEIK 262
7tmB1_VIP-R1 cd15269
vasoactive intestinal polypeptide (VIP) receptor 1, member of the class B family of ...
544-792 1.31e-21

vasoactive intestinal polypeptide (VIP) receptor 1, member of the class B family of seven-transmembrane G protein-coupled receptors; Vasoactive intestinal peptide (VIP) receptor 1 is a member of the group of G protein-coupled receptors for structurally similar peptide hormones that also include secretin, growth-hormone-releasing hormone (GHRH), and pituitary adenylate cyclase activating polypeptide (PACAP). These receptors are classified into the subfamily B1 of class B GRCRs that consists of the classical hormone receptors and have been identified in all the vertebrates, from fishes to mammals, but are not present in plants, fungi, or prokaryotes. For all class B receptors, the large N-terminal extracellular domain plays a critical role in peptide hormone recognition. VIP and PACAP exert their effects through three G protein-coupled receptors, PACAP-R1, VIP-R1 (vasoactive intestinal receptor type 1, also known as VPAC1) and VIP-R2 (or VPAC2). PACAP-R1 binds only PACAP with high affinity, whereas VIP-R1 and -R2 specifically bind and respond to both VIP and PACAP. VIP and PACAP and their receptors are widely expressed in the brain and periphery. They are upregulated in neurons and immune cells in responses to CNS injury and/or inflammation and exert potent anti-inflammatory effects, as well as play important roles in the control of circadian rhythms and stress responses, among many others. VIP-R1 is preferentially coupled to a stimulatory G(s) protein, which leads to the activation of adenylate cyclase and thereby increases in intracellular cAMP level. However, depending on its cellular location, VIP-R1 is also capable of coupling to additional G proteins such as G(q) protein, thus leading to the activation of phospholipase C and intracellular calcium influx.


Pssm-ID: 320397 [Multi-domain]  Cd Length: 268  Bit Score: 95.31  E-value: 1.31e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 544 VGCSLSVLCLVATLVTFAVLSSVSTIRNQrYHIHANLSF-----AVLVAQVLLLISFRLE---PGTTPCQVMAVLLHYFF 615
Cdd:cd15269   10 IGHSLSLISLTAAMIILCLFRKLHCTRNY-IHMHLFMSFilraiAVFIKDAVLFESGEEDhcsVASVGCKAAMVFFQYCI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 616 LSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPlLICIISLSFAmDSYGTSNNCWLSLASGAIWAFV-APALF 694
Cdd:cd15269   89 MANFFWLLVEGLYLHTLLAVSFFSERKYFWWYILIGWGAP-SVFITAWSVA-RIYFEDVGCWDTIIESLLWWIIkTPILV 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 695 VIVVNIGILIAVTRVISQISADNYKIHGDPSAFKLTAKAVAVLLPILGTSWV-FGVLAVNGCAVVFQYMFATLNSLQGLF 773
Cdd:cd15269  167 SILVNFILFICIIRILVQKLHSPDIGRNESSQYSRLAKSTLLLIPLFGIHYImFAFFPDNFKAEVKLVFELILGSFQGFV 246
                        250
                 ....*....|....*....
gi 767973889 774 IFLFHCLLNSEVRAAFKHK 792
Cdd:cd15269  247 VAVLYCFLNGEVQAELKRK 265
7tmB1_NPR_B3_insect-like cd15262
insect neuropeptide receptor subgroup B3 and related proteins belong to subfamily B1 of ...
550-790 1.37e-21

insect neuropeptide receptor subgroup B3 and related proteins belong to subfamily B1 of hormone receptors; member of the class B secretin-like seven-transmembrane G protein-coupled receptors; This subgroup includes a neuropeptide receptor found in Bombyx mori (silk worm) and its closely related proteins from arthropods. They belong to the B1 subfamily of class B GPCRs, also referred to as secretin-like receptor family, which includes receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), calcitonin gene-related peptide, parathyroid hormone (PTH), and corticotropin-releasing factor. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of the B1 subfamily preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. The class B GPCRs have been identified in all the vertebrates, from fishes to mammals, as well as invertebrates including Caenorhabditis elegans and Drosophila melanogaster, but are not present in plants, fungi, or prokaryotes.


Pssm-ID: 320390 [Multi-domain]  Cd Length: 270  Bit Score: 95.59  E-value: 1.37e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 550 VLCLVATLVTFavlsSVSTIRNQRYHIHANLSFAVLVAQVLLLIS---FRLEPGTTP------------CQVMAVLLHYF 614
Cdd:cd15262   17 VTSLPAVFIFY----SYKRLRITRVILHRNLLISIIIRNILVIISkvfVILDALTSSgddtvmnqnavvCRLLSIFERAA 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 615 FLSAFAWMLVEGLHLYSMVIKVFgSEDSKHRYYYGMGWGFPLLICIISLSFAMDSYGTSnnCWLSLASGAIWAFVAPALF 694
Cdd:cd15262   93 RNAVFACMFVEGFYLHRLIVAVF-AEKSSIRFLYVIGAVLPLFPVIIWAIIRALHNDHS--CWVVDIEGVQWVLDTPRLF 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 695 VIVVNIGILIAVTRVIsqisADNYKIHGDPSAFKLTAKAVAVLLPILGTSWVFGVL--AVNGCAV--VFQYMFATLNSLQ 770
Cdd:cd15262  170 ILLVNTVLLVDIIRVL----VTKLRNTEENSQTKSTTRATLFLVPLFGLHFVITAYrpSTDDCDWedIYYYANYLIEGLQ 245
                        250       260
                 ....*....|....*....|
gi 767973889 771 GLFIFLFHCLLNSEVRAAFK 790
Cdd:cd15262  246 GFLVAILFCYINKEVHYLIK 265
7tmB1_CRF-R2 cd15446
corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane ...
541-792 2.14e-21

corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors; The vertebrate corticotropin-releasing factor (CRF) receptors are predominantly expressed in central nervous system with high levels in cortex tissue, brain stem, and pituitary. They have two isoforms as a result of alternative splicing of the same receptor gene: CRF-R1 and CRF-R2, which differ in tissue distribution and ligand binding affinities. Recently, a third CRF receptor (CRF-R3) has been identified in catfish pituitary. The catfish CRF-R1 is highly homologous to CRF-R3. CRF is a 41-amino acid neuropeptide that plays a central role in coordinating neuroendocrine, behavioral, and autonomic responses to stress by acting as the primary neuroregulator of the hypothalamic-pituitary-adrenal axis, which controls the levels of cortisol and other stress related hormones. In addition, the CRF family of neuropeptides also includes structurally related peptides such as mammalian urocortin, fish urotensin I, and frog sauvagine. The actions of CRF and CRF-related peptides are mediated through specific binding to CRF-R1 and CRF-R2. CRF and urocortin 1 bind and activate mammalian CRF-R1 with similar high affinities. By contrast, urocortin 2 and urocortin 3 do not bind to CRF-R1 or stimulate CRF-R1-mediated cAMP formation. Urocortin 1 also shows high affinity for mammalian CRF-R2, whereas CRF has significantly lower affinity for this receptor. These evidence suggest that urocortin 1 is an endogenous ligand for CRF-R1 and CRF-R2. The CRF receptors are members of the B1 subfamily of class B GPCRs, also referred to as secretin-like receptor family, which includes receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), calcitonin gene-related peptide, and parathyroid hormone (PTH). These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of the B1 subfamily preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. However, depending on its cellular location and function, CRF receptors can activate multiple G proteins, which can in turn stimulate different second messenger pathways.


Pssm-ID: 320562 [Multi-domain]  Cd Length: 264  Bit Score: 94.64  E-value: 2.14e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 541 ISYVGCSLSVLCLVATLVTFAVLSSVSTIRNQryhIHANLSFAVLVAQV----LLLISFRLEPGTTP-CQVMAVLLHYFF 615
Cdd:cd15446    7 INYLGHCISVGALVVAFLLFLCLRSIRCLRNI---IHWNLITTFILRNVmwflLQMIDHNIHESNEVwCRCITTIYNYFV 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 616 LSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPlliCIISLSFAMDS-YGTSNNCWLSLASGAI--WAFVAPA 692
Cdd:cd15446   84 VTNFFWMFVEGCYLHTAIVMTYSTDKLRKWVFLFIGWCIP---CPIIVAWAIGKlYYENEQCWFGKEPGKYidYIYQGPV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 693 LFVIVVNIGILIAVTRVIsqISADNYKIHGDPSAFKLTAKAVAVLLPILGTSWVfgVLAVNG-----CAVVFQYMFATLN 767
Cdd:cd15446  161 ILVLLINFVFLFNIVRIL--MTKLRASTTSETIQYRKAVKATLVLLPLLGITYM--LFFVNPgeddiSQIVFIYFNSFLQ 236
                        250       260
                 ....*....|....*....|....*
gi 767973889 768 SLQGLFIFLFHCLLNSEVRAAFKHK 792
Cdd:cd15446  237 SFQGFFVSVFYCFLNGEVRSAARKR 261
7tmB1_GlucagonR-like_1 cd15985
uncharacterized group of glucagon receptor-like proteins, member of the class B family of ...
536-792 6.23e-21

uncharacterized group of glucagon receptor-like proteins, member of the class B family of seven-transmembrane G protein-coupled receptors; This group consists of uncharacterized proteins with similarity to members of the glucagon receptor family of G protein-coupled receptors, which include glucagon receptor (GCGR), and glucagon-like peptide-1 receptor (GLP1R), and GLP2R. The glucagon receptors are activated by the members of the glucagon (GCG) peptide family including GCG, glucagon-like peptide 1 (GLP1), and GLP2, which are derived from the large proglucagon precursor. GCGR regulates blood glucose levels by control of hepatic glycogenolysis and gluconeogenesis and by regulation of insulin secretion from the pancreatic beta-cells. Activation of GLP1R stimulates glucose-dependent insulin secretion from pancreatic beta cells, whereas activation of GLP2R stimulates intestinal epithelial proliferation and increases villus height in the small intestine. Receptors in this group belong to the B1 (or secretin-like) subfamily of class B GPCRs, which includes receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, calcitonin gene-related peptide, parathyroid hormone (PTH), and corticotropin-releasing factor. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of the B1 subfamily preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. However, depending on their cellular location, GCGR and GLP receptors can activate multiple G proteins, which can in turn stimulate different second messenger pathways.


Pssm-ID: 320651 [Multi-domain]  Cd Length: 280  Bit Score: 93.84  E-value: 6.23e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 536 VALSSISYVGCSLSVLCLVATLVtfaVLSSVSTIRNQRYHIHANL--SFA-----VLVAQVLL----------------L 592
Cdd:cd15985    2 VSFRMLYTVGYTLSLLTLVSALL---ILTSIRKLHCTRNYIHANLfaSFIlravsVIVKDTLLerrwgreimrvadwgeL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 593 ISFRLEPGttpCQVMAVLLHYFFLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLICiisLSFAMDSYGT 672
Cdd:cd15985   79 LSHKAAIG---CRMAQVVMQYCILANHYWFFVEAVYLYKLLIGAVFSEKNYYLLYLYLGWGTPVLFV---VPWMLAKYLK 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 673 SNN-CWLSLASGAIWAFVA-PALFVIVVNIGILIAVTRVISQISADNYKIHGDpsaFKLT-AKAVAVLLPILGTSWVFGV 749
Cdd:cd15985  153 ENKeCWALNENMAYWWIIRiPILLASLINLLIFMRILKVILSKLRANQKGYAD---YKLRlAKATLTLIPLFGIHEVVFI 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 767973889 750 LAVNGCAV-------VFQYMFatLNSLQGLFIFLFHCLLNSEVRAAFKHK 792
Cdd:cd15985  230 FATDEQTTgilryikVFFTLF--LNSFQGFLVAVLYCFANKEVKSELLKK 277
7tmB1_CRF-R1 cd15445
corticotropin-releasing factor receptor 1, member of the class B family of seven-transmembrane ...
541-792 6.80e-21

corticotropin-releasing factor receptor 1, member of the class B family of seven-transmembrane G protein-coupled receptors; The vertebrate corticotropin-releasing factor (CRF) receptors are predominantly expressed in central nervous system with high levels in cortex tissue, brain stem, and pituitary. They have two isoforms as a result of alternative splicing of the same receptor gene: CRF-R1 and CRF-R2, which differ in tissue distribution and ligand binding affinities. Recently, a third CRF receptor (CRF-R3) has been identified in catfish pituitary. The catfish CRF-R1 is highly homologous to CRF-R3. CRF is a 41-amino acid neuropeptide that plays a central role in coordinating neuroendocrine, behavioral, and autonomic responses to stress by acting as the primary neuroregulator of the hypothalamic-pituitary-adrenal axis, which controls the levels of cortisol and other stress related hormones. In addition, the CRF family of neuropeptides also includes structurally related peptides such as mammalian urocortin, fish urotensin I, and frog sauvagine. The actions of CRF and CRF-related peptides are mediated through specific binding to CRF-R1 and CRF-R2. CRF and urocortin 1 bind and activate mammalian CRF-R1 with similar high affinities. By contrast, urocortin 2 and urocortin 3 do not bind to CRF-R1 or stimulate CRF-R1-mediated cAMP formation. Urocortin 1 also shows high affinity for mammalian CRF-R2, whereas CRF has significantly lower affinity for this receptor. These evidence suggest that urocortin 1 is an endogenous ligand for CRF-R1 and CRF-R2. The CRF receptors are members of the B1 subfamily of class B GPCRs, also referred to as secretin-like receptor family, which includes receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), calcitonin gene-related peptide, and parathyroid hormone (PTH). These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of the B1 subfamily preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. However, depending on its cellular location and function, CRF receptors can activate multiple G proteins, which can in turn stimulate different second messenger pathways.


Pssm-ID: 320561 [Multi-domain]  Cd Length: 265  Bit Score: 93.46  E-value: 6.80e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 541 ISYVGCSLSvlcLVATLVTFAVLSSVSTIRNQRYHIHANLSFAVLVAQVL-LLISFRLEP-----GTTPCQVMAVLLHYF 614
Cdd:cd15445    7 INYLGHCIS---LVALLVAFVLFLRLRSIRCLRNIIHWNLITAFILRNATwFVVQLTMSPevhqsNVVWCRLVTAAYNYF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 615 FLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLICIislSFAMDS-YGTSNNCWLSLASGAIWAFV--AP 691
Cdd:cd15445   84 HVTNFFWMFGEGCYLHTAIVLTYSTDKLRKWMFICIGWCIPFPIIV---AWAIGKlYYDNEKCWFGKRAGVYTDYIyqGP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 692 ALFVIVVNIGILIAVTRVI-SQISADNYKihgDPSAFKLTAKAVAVLLPILGTSWVFGVLAVNG---CAVVFQYMFATLN 767
Cdd:cd15445  161 MILVLLINFIFLFNIVRILmTKLRASTTS---ETIQYRKAVKATLVLLPLLGITYMLFFVNPGEdeiSRIVFIYFNSFLE 237
                        250       260
                 ....*....|....*....|....*
gi 767973889 768 SLQGLFIFLFHCLLNSEVRAAFKHK 792
Cdd:cd15445  238 SFQGFFVSVFYCFLNSEVRSAVRKR 262
7tmB2_GPR97 cd15442
orphan adhesion receptor GPR97, member of the class B2 family of seven-transmembrane G ...
538-781 1.07e-20

orphan adhesion receptor GPR97, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR97 is an orphan receptor that has been classified into the group VIII of adhesion GPCRs. Other members of the Group VII include GPR56, GPR64, GPR112, GPR114, and GPR126. GPR97 is identified as a lymphatic adhesion receptor that is specifically expressed in lymphatic endothelium, but not in blood vascular endothelium, and is shown to regulate migration of lymphatic endothelial cells via the small GTPases RhoA and cdc42. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320558 [Multi-domain]  Cd Length: 277  Bit Score: 92.94  E-value: 1.07e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 538 LSSISYVGCSLSVLCLVATLVTFAVLSSVSTI--RNQRYHIHANLSFAVLVAQVLLLISFRLEPGTTP--CQVMAVLLHY 613
Cdd:cd15442    4 LVTISSAGCGVSMVFLIFTIILYFFLRFTYQKfkSEDAPKIHVNLSSSLLLLNLAFLLNSGVSSRAHPglCKALGGVTHY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 614 FFLSAFAWMLVEGLHLYSMVIKVFGsedSKHRYYYG----MGWGFPLLICIISLSfaMDSYGTSNN-----------CWL 678
Cdd:cd15442   84 FLLCCFTWMAIEAFHLYLLAIKVFN---TYIHHYFAklclVGWGFPALVVTITGS--INSYGAYTImdmanrttlhlCWI 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 679 SLASGAIWAFVAPALFVIVVNIGILI---AVTRVISQISADNYKIHGDPSAFKLTakaVAVLLPILGTSWVFGVLAVNGC 755
Cdd:cd15442  159 NSKHLTVHYITVCGYFGLTFLFNTVVlglVAWKIFHLQSATAGKEKCQAWKGGLT---VLGLSCLLGVTWGLAFFTYGSM 235
                        250       260
                 ....*....|....*....|....*.
gi 767973889 756 AVVFQYMFATLNSLQGLFIFLFHCLL 781
Cdd:cd15442  236 SVPTVYIFALLNSLQGLFIFIWFVIL 261
7tmB1_calcitonin_R cd15274
calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled ...
537-790 1.27e-20

calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors; This group includes G protein-coupled receptors for calcitonin (CT) and calcitonin gene-related peptides (CGRPs). Calcitonin, a 32-amino acid peptide hormone, is involved in calcium metabolism in many mammalian species and acts to reduce blood calcium levels and directly inhibits bone resorption by acting on osteoclast. Thus, CT acts as an antagonist to parathyroid hormone and is commonly used in the treatment of bone disorders. The CT receptor is predominantly found in osteoclasts, kidney, and brain, and is primarily coupled to stimulatory G(s) protein, which leads to activation of adenylate cyclase, thereby increasing cAMP production. CGRP, a member of the calcitonin family of peptides, is a potent vasodilator and may contribute to migraine. It is expressed in the peripheral and central nervous system and exists in two forms in humans (alpha-CGRP and beta-CGRP). CGRP meditates its physiological effects through calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1), a single transmembrane domain protein. Thus, the CRLR/RAMP1 complex serves as a functional CGRP receptor. On the other hand, the CRLR/RAMP2 and CRLR/RAMP3 complexes function as adrenomedullin-specific receptors. The CT and CGRP receptors belong to the B1 subfamily of class B GPCRs, also referred to as secretin-like receptor family, which includes receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), parathyroid hormone (PTH), and corticotropin-releasing factor. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide.


Pssm-ID: 341343 [Multi-domain]  Cd Length: 274  Bit Score: 92.53  E-value: 1.27e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 537 ALSSISYVGCSLSVLCLVATLVTFAVLSSVSTirnQRYHIHANLSFAVLVAQVLLLISF--------RLEPGTTPCQVMA 608
Cdd:cd15274    3 NLYYLAIVGHSLSIATLLISLGIFFFFRSLSC---QRVTLHKNLFLSYILNSIIIIIHLvavvpngeLVARNPVSCKILH 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 609 VLLHYFFLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLICIISLsfAMDSYGTSNNCWLSLASGAIWAF 688
Cdd:cd15274   80 FIHQYMMGCNYFWMLCEGIYLHTLIVVAVFAEKQRLMWYYLLGWGFPLIPTTIHA--ITRAVYYNDNCWLSSETHLLYII 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 689 VAPALFVIVVNIGILIAVTRVISQISADNykiHGDPSAFKLTA-KAVAVLLPILGTSWVFGVLAVNGCAV--VFQYMFAT 765
Cdd:cd15274  158 HGPIMAALVVNFFFLLNIVRVLVTKLRET---HEAESHMYLKAvKATLILVPLLGIQFVLFPWRPSGKILgkIYDYVMHS 234
                        250       260
                 ....*....|....*....|....*
gi 767973889 766 LNSLQGLFIFLFHCLLNSEVRAAFK 790
Cdd:cd15274  235 LIHFQGFFVATIFCFCNGEVQATLK 259
7tmB1_PTH-R_related cd15272
invertebrate parathyroid hormone-related receptors, member of the class B family of ...
544-796 5.14e-20

invertebrate parathyroid hormone-related receptors, member of the class B family of seven-transmembrane G protein-coupled receptors; This group includes parathyroid hormone (PTH)-related receptors found in invertebrates such as mollusks and annelid worms. The PTH family receptors are members of the B1 subfamily of class B GPCRs, which includes receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), and calcitonin gene-related peptide. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. The parathyroid hormone type 1 receptor (PTH1R) is found in all vertebrate species and is activated by two polypeptide ligands: parathyroid hormone (PTH), an endocrine hormone that regulates calcium homoeostasis and bone maintenance, and PTH-related peptide (PTHrP), a paracrine factor that regulates endochondral bone development. PTH1R couples predominantly to G(s)- protein that in turn activates adenylyl cyclase thereby producing cAMP, but it can also couple to several G protein subtypes, including G(q/11), G(i/o), and G(12/13), resulting in activation of multiple signaling pathways.


Pssm-ID: 320400 [Multi-domain]  Cd Length: 285  Bit Score: 91.30  E-value: 5.14e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 544 VGCSLSvlcLVATLVTFAVLSSVSTIRNQRYHIHANL--SFAVLVAQVLL---------------------LISFRLEPG 600
Cdd:cd15272   10 IGYGLS---LVSLLIAVIIMLYFKKLHCPRNTIHINLfvSFILRAVLSFIkenllvqgvgfpgdvyydsngVIEFKDEGS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 601 TTPCQVMAVLLHYFFLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLiCIISLSFaMDSYGTSNNCW-LS 679
Cdd:cd15272   87 HWECKLFFTMFNYILGANYMWIFVEGLYLHMLIFVAVFSENSRVKWYILLGWLSPLL-FVLPWVF-VRATLEDTLCWnTN 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 680 LASGAIWAFVAPALFVIVVNIGILIAVTRVI-SQISADNYKiHGDPSAFKLTAKAVAVLLPILGT-----SWVFGVLAVN 753
Cdd:cd15272  165 TNKGYFWIIRGPIVISIAINFLFFINIVRVLfTKLKASNTQ-ESRPFRYRKLAKSTLVLIPLFGVhymvfVVLPDSMSSD 243
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 767973889 754 GCAVVFQYMFATLNSLQGLFIFLFHCLLNSEVRAAFKhktKVW 796
Cdd:cd15272  244 EAELVWLYFEMFFNSFQGFIVALLFCFLNGEVQSEIK---KKW 283
7tmB2_GPR128 cd15257
orphan adhesion receptor GPR128, member of the class B2 family of seven-transmembrane G ...
536-776 7.12e-20

orphan adhesion receptor GPR128, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR128 is an orphan receptor of the adhesion family (subclass B2) that belongs to the class B GPCRs. Expression of GPR128 was detected in the mouse intestinal mucosa and is thought to be involved in energy balance, as its knockout mice showed a decrease in body weight gain and an increase in intestinal contraction frequency compared to wild-type controls. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. These include, for example, EGF (epidermal growth factor)-like domains in CD97, Celsr1 (cadherin family member), Celsr2, Celsr3, EMR1 (EGF-module-containing mucin-like hormone receptor-like 1), EMR2, EMR3, and Flamingo; two laminin A G-type repeats and nine cadherin domains in Flamingo and its human orthologs Celsr1, Celsr2 and Celsr3; olfactomedin-like domains in the latrotoxin receptors; and five or four thrombospondin type 1 repeats in BAI1 (brain-specific angiogenesis inhibitor 1), BAI2 and BAI3. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320385 [Multi-domain]  Cd Length: 303  Bit Score: 91.09  E-value: 7.12e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 536 VALSSISYVGCSLSVLCLVATLV-------------------------TFAVLSsVSTIRNQRYHIHANlSFAVLVAQVL 590
Cdd:cd15257    2 KTLDIISTIGCVLSIAGLVITIIfhlhtrklrkssvtwvllnlcssllLFNIIF-TSGVENTNNDYEIS-TVPDRETNTV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 591 LLISFRLEPGTTPCQVMAVLLHYFFLSAFAWMLVEGLHLYSMVIKVFGSedSKHRYYYGM---GWGFPLLICII------ 661
Cdd:cd15257   80 LLSEEYVEPDTDVCTAVAALLHYFLLVTFMWNAVYSAQLYLLLIRMMKP--LPEMFILQAsaiGWGIPAVVVAItlgaty 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 662 ----SLSFAMDSYGTSNNCWL-------SLASGAIWAFVAPALFVIVVNIGILIAVTRVISQISADNYKIHGDPSAFKLT 730
Cdd:cd15257  158 rfptSLPVFTRTYRQEEFCWLaaldknfDIKKPLLWGFLLPVGLILITNVILFIMTSQKVLKKNNKKLTTKKRSYMKKIY 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 767973889 731 -AKAVAVLlpiLGTSWVFG--VLAVNG-CAVVFQYMFATLNSLQGLFIFL 776
Cdd:cd15257  238 iTVSVAVV---FGITWILGylMLVNNDlSKLVFSYIFCITNTTQGVQIFI 284
7tmB1_NPR_B7_insect-like cd15273
insect neuropeptide receptor subgroup B7 and related proteins, member of the class B family of ...
541-792 1.15e-19

insect neuropeptide receptor subgroup B7 and related proteins, member of the class B family of seven-transmembrane G protein-coupled receptors; This subgroup includes a neuropeptide receptor found in Nilaparvata lugens (brown planthopper) and its closely related proteins from invertebrates. They belong to the B1 subfamily of class B GPCRs, also referred to as secretin-like receptor family, which includes receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), calcitonin gene-related peptide, parathyroid hormone (PTH), and corticotropin-releasing factor. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of the B1 subfamily preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. The class B GPCRs have been identified in all the vertebrates, from fishes to mammals, as well as invertebrates including Caenorhabditis elegans and Drosophila melanogaster, but are not present in plants, fungi, or prokaryotes.


Pssm-ID: 320401 [Multi-domain]  Cd Length: 285  Bit Score: 90.12  E-value: 1.15e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 541 ISYVGCSLSvlcLVATLVTFAVLSSVSTIRNQR--YHIHANLSFaVLVAQVLLLI-----------------------SF 595
Cdd:cd15273    7 ISQIGYIVS---LITLIIAFAIFLSFKKLHCARnkLHMHLFASF-ILRAFMTLLKdslfidglglladiverngggneVI 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 596 RLEPGTTPCQVMAVLLHYFFLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLICIislSFAMDSYGTSNN 675
Cdd:cd15273   83 ANIGSNWVCKAITSLWQYFIIANYSWILMEGLYLHNLIFLALFSDENNIILYILLGWGLPLIFVV---PWIVARILFENS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 676 -CWLSLASGAIWAFV-APALFVIVVNIGILIAVTRVI-----SQISADNYKihgdpsaFKLTAKAVAVLLPILGTSW--- 745
Cdd:cd15273  160 lCWTTNSNLLNFLIIrIPIMISVLINFILFLNIVRVLlvklrSSVNEDSRR-------YKKWAKSTLVLVPLFGVHYtif 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 767973889 746 -VFGVLAVNGCAVVFQYMF--ATLNSLQGLFIFLFHCLLNSEVRAAFKHK 792
Cdd:cd15273  233 lILSYLDDTNEAVELIWLFcdQLFASFQGFFVALLYCFLNGEVRAEIQRK 282
7tmB1_VIP-R2 cd15986
vasoactive intestinal polypeptide (VIP) receptor 2, member of the class B family of ...
536-792 2.14e-19

vasoactive intestinal polypeptide (VIP) receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors; Vasoactive intestinal peptide (VIP) receptor 2 is a member of the group of G protein-coupled receptors for structurally similar peptide hormones that also include secretin, growth-hormone-releasing hormone (GHRH), and pituitary adenylate cyclase activating polypeptide (PACAP). These receptors are classified into the subfamily B1 of class B GRCRs that consists of the classical hormone receptors and have been identified in all the vertebrates, from fishes to mammals, but are not present in plants, fungi, or prokaryotes. For all class B receptors, the large N-terminal extracellular domain plays a critical role in peptide hormone recognition. VIP and PACAP exert their effects through three G protein-coupled receptors, PACAP-R1, VIP-R1 (vasoactive intestinal receptor type 1, also known as VPAC1) and VIP-R2 (or VPAC2). PACAP-R1 binds only PACAP with high affinity, whereas VIP-R1 and -R2 specifically bind and respond to both VIP and PACAP. VIP and PACAP and their receptors are widely expressed in the brain and periphery. They are upregulated in neurons and immune cells in responses to CNS injury and/or inflammation and exert potent anti-inflammatory effects, as well as play important roles in the control of circadian rhythms and stress responses, among many others. VIP-R1 is preferentially coupled to a stimulatory G(s) protein, which leads to the activation of adenylate cyclase and thereby increases in intracellular cAMP level. However, depending on its cellular location, VIP-R1 is also capable of coupling to additional G proteins such as G(q) protein, thus leading to the activation of phospholipase C and intracellular calcium influx.


Pssm-ID: 320652 [Multi-domain]  Cd Length: 269  Bit Score: 89.09  E-value: 2.14e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 536 VALSSISYVGCSLSVLCLVATLVTFAVLSSVSTIRNqryHIHANLSF-------AVLVAQVLLLISFRLEPGTTP----- 603
Cdd:cd15986    2 IVVKTIYTLGHSVSLIALTTGSTILCLFRKLHCTRN---YIHLNLFFsfilraiSVLVKDDILYSSSNTEHCTVPpslig 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 604 CQVMAVLLHYFFLSAFAWMLVEGLHLYSMVIKVFgSEDSKHRYYYGMGWGFPlLICIISLSFAMdSYGTSNNCW-LSLAS 682
Cdd:cd15986   79 CKVSLVILQYCIMANFYWLLVEGLYLHTLLVVIF-SENRHFIVYLLIGWGIP-TVFIIAWIVAR-IYLEDTGCWdTNDHS 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 683 GAIWAFVAPALFVIVVNIGILIAVTRVISQISADNYKIHGDPSAFKLTAKAVAVLLPILGTSWVFGVLAVNGCAVVFQYM 762
Cdd:cd15986  156 VPWWVIRIPIIISIILNFILFISIIRILLQKLRSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYIVFVYFPDSSSSNYQIF 235
                        250       260       270
                 ....*....|....*....|....*....|.
gi 767973889 763 FA-TLNSLQGLFIFLFHCLLNSEVRAAFKHK 792
Cdd:cd15986  236 FElCLGSFQGLVVAILYCFLNSEVQGELKRK 266
7tmB1_PTHR cd15265
parathyroid hormone receptors, member of the class B family of seven-transmembrane G ...
544-798 1.27e-17

parathyroid hormone receptors, member of the class B family of seven-transmembrane G protein-coupled receptors; The parathyroid hormone (PTH) receptor family has three subtypes: PTH1R, PTH2R and PTH3R. PTH1R is expressed in bone and kidney and is activated by two polypeptide ligands: PTH, an endocrine hormone that regulates calcium homoeostasis and bone maintenance, and PTH-related peptide (PTHrP), a paracrine factor that regulates endochondral bone development. PTH1R couples predominantly to a G(s)-protein that in turn activates adenylate cyclase thereby producing cAMP, but it can also couple to several G protein subtypes, including G(q/11), G(i/o), and G(12/13), resulting in activation of multiple intracellular signaling pathways. PTH2R is potently activated by tuberoinfundibular peptide-39 (TIP-39), but not by PTHrP. PTH also strongly activates human PTH2R, but only weakly activates rat and zebrafish PTH2Rs, suggesting that TIP-39 is a natural ligand for PTH2R. On the other hand, PTH3R binds and responds to both PTH and PTHrP, but not the TIP-39. Moreover, the PTH3R is more closely related to the PTH1R than PTH2R. PTH1R is found in all vertebrate species, whereas PTH2R is found in mammals and fish, but not in chicken or frog. The PTH3R is found in chicken and fish, but it is absent in mammals. The PTH receptors are members of the B1 (or secretin-like) subfamily of class B GPCRs, which include receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), and calcitonin gene-related peptide. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways.


Pssm-ID: 320393 [Multi-domain]  Cd Length: 289  Bit Score: 84.35  E-value: 1.27e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 544 VGCSLSvlcLVATLVTFAVLSSVSTIRNQRYHIHANL--SF------------------AVLVAQVLLLISFRLEPGTTP 603
Cdd:cd15265   10 VGYSIS---LVSLTVAVFILGYFRRLHCTRNYIHMHLfvSFmlravsifvkdavlysgsGLDELERPSMEDLKSIVEAPP 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 604 --------CQVMAVLLHYFFLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLICII--SLSFAMDSYGts 673
Cdd:cd15265   87 vdksqyvgCKVAVTLFLYFLATNYYWILVEGLYLHSLIFMAFFSDKKYLWGFTLIGWGFPAVFVIPwaSVRATLADTR-- 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 674 nnCWLSLASGAIWAFVAPALFVIVVNIGILIAVTRVI-SQISADNYKIHGDPSAFKLTAKAVAVLLPILGTSW-VFGVL- 750
Cdd:cd15265  165 --CWDLSAGNYKWIYQVPILAAIVVNFILFLNIVRVLaTKLRETNAGRCDTRQQYRKLAKSTLVLIPLFGVHYiVFMGMp 242
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 767973889 751 -AVNGCAVVFQYMFATL-NSLQGLFIFLFHCLLNSEVRAAFKhktKVWSL 798
Cdd:cd15265  243 yTEVGLLWQIRMHYELFfNSFQGFFVAIIYCFCNGEVQAEIK---KRWER 289
7tmB1_PTH1R cd15984
parathyroid hormone 1 receptor, member of the class B family of seven-transmembrane G ...
538-797 1.28e-17

parathyroid hormone 1 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors; The parathyroid hormone (PTH) receptor family has three subtypes: PTH1R, PTH2R and PTH3R. PTH1R is expressed in bone and kidney and is activated by two polypeptide ligands: PTH, an endocrine hormone that regulates calcium homoeostasis and bone maintenance, and PTH-related peptide (PTHrP), a paracrine factor that regulates endochondral bone development. PTH1R couples predominantly to G(s)-protein that in turn activates adenylate cyclase thereby producing cAMP, but it can also couple to several G protein subtypes, including G(q/11), G(i/o), and G(12/13), resulting in activation of multiple intracellular signaling pathways. PTH1R is found in all vertebrate species, whereas PTH2R is found in mammals and fish, but not in chicken or frog. PTH3R is found in chicken and fish, but it is absent in mammals. The PTH receptors are members of the B1 (or secretin-like) subfamily of class B GPCRs, which include receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), and calcitonin gene-related peptide. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways.


Pssm-ID: 320650 [Multi-domain]  Cd Length: 290  Bit Score: 84.23  E-value: 1.28e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 538 LSSISYVGCSLSVLCLVATLVTFAVLSSVSTIRNQrYHIHANLSF-----AVLVAQVLLLISFRLEP------------- 599
Cdd:cd15984    4 LYLIYTVGYSISLGSLTVAVLILGYFRRLHCTRNY-IHMHLFLSFmlravSIFVKDAVLYSGSALEEmeriteedlksit 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 600 --------GTTPCQVMAVLLHYFFLSAFAWMLVEGLHLYSMVIKVFGSEdskHRYYYG---MGWGFPLLICIISLSFAMD 668
Cdd:cd15984   83 eappadkaQFVGCKVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSE---KKYLWGftlFGWGLPAVFVTIWASVRAT 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 669 SYGTSnnCWLSLASGAIWAFVAPALFVIVVNIGILIAVTRVI-SQISADNYKIHGDPSAFKLTAKAVAVLLPILGTSWV- 746
Cdd:cd15984  160 LADTG--CWDLSAGNLKWIIQVPILAAIVVNFILFINIVRVLaTKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVHYIv 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767973889 747 ---FGVLAVNGCAVVFQYMFATL-NSLQGLFIFLFHCLLNSEVRAAFKhktKVWS 797
Cdd:cd15984  238 fmaMPYTEVSGILWQVQMHYEMLfNSFQGFFVAIIYCFCNGEVQAEIK---KSWS 289
7tmB1_secretin cd15275
secretin receptor, member of the class B family of seven-transmembrane G protein-coupled ...
544-786 2.54e-17

secretin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors; Secretin receptor is a member of the group of G protein-coupled receptors for structurally similar peptide hormones that also include vasoactive intestinal peptide (VIP), growth-hormone-releasing hormone (GHRH), and pituitary adenylate cyclase activating polypeptide (PACAP). These receptors are classified into the subfamily B1 of class B GRCRs that consists of the classical hormone receptors, and have been identified in all the vertebrates, from fishes to mammals, but are not present in plants, fungi, or prokaryotes. For all class B receptors, the large N-terminal extracellular domain plays a critical role in peptide hormone recognition. Secretin, a polypeptide secreted by entero-endocrine S cells in the small intestine, is involved in maintaining body fluid balance. This polypeptide regulates the secretion of bile and bicarbonate into the duodenum from the pancreatic and biliary ducts, as well as regulates the duodenal pH by the control of gastric acid secretion. Studies with secretin receptor-null mice indicate that secretin plays a role in regulating renal water reabsorption. Secretin mediates its biological actions by elevating intracellular cAMP via G protein-coupled secretin receptor, which is expressed in the brain, pancreas, stomach, kidney, and liver.


Pssm-ID: 320403 [Multi-domain]  Cd Length: 271  Bit Score: 82.87  E-value: 2.54e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 544 VGCSLSvlcLVATLVTFAVLSSVSTIRNQRYHIHANLSFAVLVAQVLLLI----------SFRLEPGTTPCQVMAVLLHY 613
Cdd:cd15275   10 VGYSVS---LVSLAIALAILCSFRRLHCTRNYIHMQLFLSFILRAISIFIkdavlfssedDNHCDIYTVGCKVAMVFSNY 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 614 FFLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLIcIISLSFAMDSYgTSNNCWLSLASGAIWAFV-APA 692
Cdd:cd15275   87 CIMANYSWLLVEGLYLHSLLSISFFSERKHLWWYIALGWGSPLIF-IISWAIARYLH-ENEGCWDTRRNAWIWWIIrGPV 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 693 LFVIVVNIGILIAVTRV-ISQISADNykIHG-DPSAFKLTAKAVAVLLPILGTSWV----FGVLAVNGCAVVFQYMFATL 766
Cdd:cd15275  165 ILSIFVNFILFLNILRIlMRKLRAPD--MRGnEFSQYKRLAKSTLLLIPLFGLHYIlfafFPEDVSSGTMEIWLFFELAL 242
                        250       260
                 ....*....|....*....|
gi 767973889 767 NSLQGLFIFLFHCLLNSEVR 786
Cdd:cd15275  243 GSFQGFVVAVLYCFLNGEVQ 262
7tmB1_GHRHR cd15270
growth-hormone-releasing hormone receptor, member of the class B family of seven-transmembrane ...
541-792 2.80e-17

growth-hormone-releasing hormone receptor, member of the class B family of seven-transmembrane G protein-coupled receptors; Growth hormone-releasing hormone receptor (GHRHR) is a member of the group of G protein-coupled receptors for structurally similar peptide hormones that also include secretin, pituitary adenylate cyclase activating polypeptide (PACAP), and vasoactive intestinal peptide. These receptors are classified into the subfamily B1 of class B GRCRs that consists of the classical hormone receptors and have been identified in all the vertebrates, from fishes to mammals, but are not present in plants, fungi, or prokaryotes. For all class B receptors, the large N-terminal extracellular domain plays a critical role in peptide hormone recognition. GHRHR is a specific receptor for the growth hormone-releasing hormone (GHRH) that controls the synthesis and release of growth hormone (GH) from the anterior pituitary somatotrophs. Mutations in the gene encoding GHRHR have been connected to isolated growth hormone deficiency (IGHD), a short-stature condition caused by deficient production of GH or lack of GH action. GHRH is preferentially coupled to a stimulatory G(s) protein, which leads to the activation of adenylate cyclase and thereby increases in intracellular cAMP level. GHRHR is found in mammals as well as zebrafish and chicken, whereas the GHRHR type 2, an ortholog of the GHRHR, has only been identified in ray-finned fish, chicken and Xenopus. Xenopus laevis GHRHR2 has been shown to interact with both endogenous GHRH and PACAP-related peptide (PRP).


Pssm-ID: 320398 [Multi-domain]  Cd Length: 268  Bit Score: 82.92  E-value: 2.80e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 541 ISYVGCSLSVLCLVatlVTFAVLSSVSTIRNQRYHIHANLSF-------AVLVAQVLLLISFRLEP---GTTPCQVMAVL 610
Cdd:cd15270    7 IYTVGYSISIVSLC---VAVAILVAFRRLHCPRNYIHIQLFFtfilkaiAVFIKDAALFQEDDTDHcsmSTVLCKVSVVF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 611 LHYFFLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLiCIISLSFAmDSYGTSNNCW-LSLASGAIWAFV 689
Cdd:cd15270   84 CHYCVMTNFFWLLVEAVYLNCLLASSFPRGKRYFWWLVLLGWGLPTL-CTGTWILC-KLYFEDTECWdINNDSPYWWIIK 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 690 APALFVIVVNIGILIAVTRVISQiSADNYKIHGDPSA-FKLTAKAVAVLLPILGTSW-VFGVLAVNGCAVVFQYMFATLN 767
Cdd:cd15270  162 GPIVISVGVNFLLFLNIIRILLK-KLDPRQINFNNSAqYRRLSKSTLLLIPLFGTHYiIFNFLPDYAGLGIRLYLELCLG 240
                        250       260
                 ....*....|....*....|....*
gi 767973889 768 SLQGLFIFLFHCLLNSEVRAAFKHK 792
Cdd:cd15270  241 SFQGFIVAVLYCFLNQEVQTEISRK 265
7tmB2_GPR123 cd16000
G protein-coupled receptor 123, member of the class B2 family of seven-transmembrane G ...
538-785 5.35e-17

G protein-coupled receptor 123, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR123 is an orphan receptor that has been classified as that belongs to the group III of adhesion GPCRs, and also includes orphan receptors GPR124 and GPR125. GPR123 is predominantly expressed in the CNS including thalamus, brain stem and regions containing large pyramidal cells, yet its biological function remains to be determined. Adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320666 [Multi-domain]  Cd Length: 275  Bit Score: 81.92  E-value: 5.35e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 538 LSSISYVGCSLSVLCLVATLVTFAVLSSvsTIRNQRYHIHANLSFAVLVAQVLLLISFRLEPGTTP--CQVMAVLLHYFF 615
Cdd:cd16000    4 LHPVVYACTAVMLLCLFASIITYIVHHS--TIRISRKGWHMLLNFCFHTALTFAVFAGGINRTKYPiiCQAVGIVLHYST 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 616 LSAFAWMLVEGLHLYSMVIK----VFGSEDSKH------RYYYGMGwGFPLLICIISLSFAMDSYGTSNN----CWLSLA 681
Cdd:cd16000   82 LSTMLWIGVTARNIYKQVTKkphlCQDTDQPPYpkqpllRFYLVSG-GVPFIICGITAATNINNYGTEDEdtpyCWMAWE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 682 SgAIWAFVAPALFVIVVNIGILIAVTRVISQISADNYKIHGDPSaFKLTAKAVAVLLPILGTSWVFGVLAVNG---CAVV 758
Cdd:cd16000  161 P-SLGAFYGPVAFIVLVTCIYFLCTYVQLRRHPERKYELKNEHS-FKAQLRAAAFTLFLFTATWAFGALAVSQghfLDMI 238
                        250       260
                 ....*....|....*....|....*..
gi 767973889 759 FQYMFATLNSLQGLFIFLFHCLLNSEV 785
Cdd:cd16000  239 FSCLYGAFCVTLGLFILIHHCAKRDDV 265
7tmB1_GCGR cd15267
glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled ...
544-787 1.76e-16

glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors; Glucagon receptor (GCGR) is a member of the glucagon receptor family of G protein-coupled receptors, which also includes glucagon-like peptide-1 receptor (GLP1R) and GLP2R. GCGR is activated by glucagon, which is derived from the large proglucagon precursor. GCGR regulates blood glucose levels by control of hepatic glycogenolysis and gluconeogenesis and by regulation of insulin secretion from the pancreatic beta-cells. Activation of GLP1R stimulates glucose-dependent insulin secretion from pancreatic beta cells, whereas activation of GLP2R stimulates intestinal epithelial proliferation and increases villus height in the small intestine. GCGR belongs to the B1 (or secretin-like) subfamily of class B GPCRs, which includes receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, calcitonin gene-related peptide, parathyroid hormone (PTH), and corticotropin-releasing factor. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of the B1 subfamily preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. However, depending on their cellular location, GCGR and GLP receptors can activate multiple G proteins, which can in turn stimulate different second messenger pathways.


Pssm-ID: 320395 [Multi-domain]  Cd Length: 281  Bit Score: 80.64  E-value: 1.76e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 544 VGCSLSvlcLVATLVTFAVLSSVSTIRNQRYHIHANL-------SFAVLVAQVLL-----------LISFRLEPGTTP-C 604
Cdd:cd15267   12 VGYSLS---LGALLLALAILGGFSKLHCMRNAIHMNLfasfilkASSVLVIDGLLrtrysqkieddLSSTWLSDEAVAgC 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 605 QVMAVLLHYFFLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLICIislSFAMDSYGTSN-NCWLSLASG 683
Cdd:cd15267   89 RVAAVFMQYGIVANYCWLLVEGIYLHNLLVLAVFPERSYFSLYLCIGWGAPALFVV---PWVVVKCLYENvQCWTSNDNM 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 684 AIWAFV-APALFVIVVNIGILIAVTRV-ISQISAdnYKIHGDPSAFKLtAKAVAVLLPILGTSWVFGVLAVNGCAV---- 757
Cdd:cd15267  166 GFWWILrFPVFLAILINFFIFVRIIQIlVSKLRA--RQMHYTDYKFRL-AKSTLTLIPLLGIHEVVFAFVTDEHAQgtlr 242
                        250       260       270
                 ....*....|....*....|....*....|...
gi 767973889 758 ---VFQYMFatLNSLQGLFIFLFHCLLNSEVRA 787
Cdd:cd15267  243 sakLFFDLF--LSSFQGLLVAVLYCFLNKEVQS 273
7tmB2_GPR56 cd15995
orphan adhesion receptor GPR56, member of the class B2 family of seven-transmembrane G ...
538-786 3.29e-16

orphan adhesion receptor GPR56, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR56 is an orphan receptor that has been classified as that belongs to the Group VIII of adhesion GPCRs. Other members of the Group VII include orphan GPCRs such as GPR64, GPR97, GPR112, GPR114, and GPR126. GPR56 is involved in the regulation of oligodendrocyte development and myelination in the central nervous system via coupling to G(12/13) proteins, which leads to the activation of RhoA GTPase. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320661  Cd Length: 269  Bit Score: 79.49  E-value: 3.29e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 538 LSSISYVGCSLSVLCLVATLvtFAVLSSVSTIRNQRYHIHANLSFAVLVAQVLLLISFRLEP--GTTPCQVMAVLLHYFF 615
Cdd:cd15995    4 LTILTYVGCIISALASVFTI--AFYLCSRRKPRDYTIYVHMNLLLAIFLLDTSFLISEPLALtgSEAACRAGGMFLHFSL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 616 LSAFAWMLVEGLHLYSMVIKVFGSEdSKHRYYY--GMGWGFPLLICIISLSFAMDSYGTSNNCWLSLASGAIWA---FVA 690
Cdd:cd15995   82 LACLTWMGIEGYNLYRLVVEVFNTY-VPHFLLKlcAVGWGLPIFLVTLIFLVDQDNYGPIILAVHRSPEKVTYAticWIT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 691 PALFVIVVNIGI--------LIAVTRVISQISADNYKIHgdpsafklTAKAVAVLLP---ILGTSW--VFGVLAVNGCAV 757
Cdd:cd15995  161 DSLISNITNLGLfslvflfnMAMLATMVVEILRLRPRTH--------KWSHVLTLLGlslVLGIPWalAFFSFASGTFQL 232
                        250       260
                 ....*....|....*....|....*....
gi 767973889 758 VFQYMFATLNSLQGLFIFLFHCLLNSEVR 786
Cdd:cd15995  233 VIVYLFTIINSLQGFLIFLWYWSMVLQAR 261
7tmB1_PACAP-R1 cd15987
pituitary adenylate cyclase-activating polypeptide type 1 receptor, member of the class B ...
536-792 5.93e-16

pituitary adenylate cyclase-activating polypeptide type 1 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors; Pituitary adenylate cyclase-activating polypeptide type 1 receptor (PACAP-R1) is a member of the group of G protein-coupled receptors for structurally similar peptide hormones that also include secretin, growth-hormone-releasing hormone (GHRH), and vasoactive intestinal peptide (VIP). These receptors are classified into the subfamily B1 of class B GRCRs that consists of the classical hormone receptors and have been identified in all the vertebrates, from fishes to mammals, but are not present in plants, fungi, or prokaryotes. For all class B receptors, the large N-terminal extracellular domain plays a critical role in peptide hormone recognition. VIP and PACAP exert their effects through three G protein-coupled receptors, PACAP-R1, VIP-R1 (vasoactive intestinal receptor type 1, also known as VPAC1) and VIP-R2 (or VPAC2). PACAP-R1 binds only PACAP with high affinity, whereas VIP-R1 and -R2 specifically bind and respond to both VIP and PACAP. VIP and PACAP and their receptors are widely expressed in the brain and periphery. They are upregulated in neurons and immune cells in responses to CNS injury and/or inflammation and exert potent anti-inflammatory effects, as well as play important roles in the control of circadian rhythms and stress responses, among many others. PACAP-R1 is preferentially coupled to a stimulatory G(s) protein, which leads to the activation of adenylate cyclase and thereby increases in intracellular cAMP level.


Pssm-ID: 320653 [Multi-domain]  Cd Length: 268  Bit Score: 78.86  E-value: 5.93e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 536 VALSSISYVGCSLSVLCLVATLVTFAVLSSVSTIRNqryHIHANLsfavLVAQVLLLISFRLEPG--------------T 601
Cdd:cd15987    2 LSVKALYTVGYSTSLVSLTTAMVILCRFRKLHCTRN---FIHMNL----FVSFILRAISVFIKDGvlyaeqdsdhcfvsT 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 602 TPCQVMAVLLHYFFLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPlLICiISLSFAMDSYGTSNNCWLSLA 681
Cdd:cd15987   75 VECKAVMVFFHYCVMSNYFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTP-TIC-VTVWAVLRLHFDDTGCWDMND 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 682 SGAIWAFV-APALFVIVVNIGILIAVTRVISQiSADNYKIHGDPSAFKLT-AKAVAVLLPILGTSWVFGVLAVNGCAVVF 759
Cdd:cd15987  153 NTALWWVIkGPVVGSIMINFVLFIGIIIILVQ-KLQSPDIGGNESSIYLRlARSTLLLIPLFGIHYTVFAFSPENVSKRE 231
                        250       260       270
                 ....*....|....*....|....*....|....
gi 767973889 760 QYMFAT-LNSLQGLFIFLFHCLLNSEVRAAFKHK 792
Cdd:cd15987  232 RLVFELgLGSFQGFVVAVLYCFLNGEVQSEIKRK 265
7tmB1_GLP1R cd15268
glucagon-like peptide-1 receptor, member of the class B family of seven-transmembrane G ...
538-790 2.89e-15

glucagon-like peptide-1 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors; Glucagon-like peptide-1 receptor (GLP1R) is a member of the glucagon receptor family of G protein-coupled receptors, which also includes glucagon receptor and GLP2R. GLP1R is activated by glucagon-like peptide 1 (GLP1), which is derived from the large proglucagon precursor. Activation of GLP1R stimulates glucose-dependent insulin secretion from pancreatic beta cells, whereas activation of GLP2R stimulates intestinal epithelial proliferation and increases villus height in the small intestine. GCGR regulates blood glucose levels by control of hepatic glycogenolysis and gluconeogenesis and by regulation of insulin secretion from the pancreatic beta-cells. Receptors in this group belong to the B1 (or secretin-like) subfamily of class B GPCRs, which includes receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, calcitonin gene-related peptide, parathyroid hormone (PTH), and corticotropin-releasing factor. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of the B1 subfamily preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. However, depending on their cellular location, GCGR and GLP receptors can activate multiple G proteins, which can in turn stimulate different second messenger pathways.


Pssm-ID: 341342 [Multi-domain]  Cd Length: 279  Bit Score: 76.91  E-value: 2.89e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 538 LSSISYVGCSLSVLCLVatlVTFAVLSSVSTIRNQRYHIHANL--SFAVLVAQVLL--------------------LISF 595
Cdd:cd15268    4 LYIIYTVGYALSFSALV---IASAILLGFRHLHCTRNYIHLNLfaSFILRALSVFIkdaalkwmystaaqqhqwdgLLSY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 596 RlepGTTPCQVMAVLLHYFFLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLICII--SLSFAMDSYGts 673
Cdd:cd15268   81 Q---DSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVFSEQRIFRLYLSIGWGVPLLFVIPwgIVKYLYEDEG-- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 674 nnCWLSLASGAIWAFVA-PALFVIVVNIGILIAVTRVISQISADNYKIHGDpSAFKLtAKAVAVLLPILGTSWVFGVLAV 752
Cdd:cd15268  156 --CWTRNSNMNYWLIIRlPILFAIGVNFLIFIRVICIVVSKLKANLMCKTD-IKCRL-AKSTLTLIPLLGTHEVIFAFVM 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 767973889 753 NGCA---VVFQYMFATLN--SLQGLFIFLFHCLLNSEVRAAFK 790
Cdd:cd15268  232 DEHArgtLRFVKLFTELSftSFQGLMVAILYCFVNNEVQMEFR 274
7tmB1_PTH3R cd15983
parathyroid hormone 3 receptor, member of the class B family of seven-transmembrane G ...
544-796 4.47e-15

parathyroid hormone 3 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors; The parathyroid hormone 3 receptor (PTH3R), one of the three subtypes of PTH receptor family, is found in chicken and fish, but it is absent in mammals. On the other hand, the PTH1R is found in all vertebrate species, whereas PTH2R is found in mammals and fish, but not in chicken or frog. PTH1R is activated by two polypeptide ligands: PTH, an endocrine hormone that regulates calcium homoeostasis and bone maintenance, and PTH-related peptide (PTHrP), a paracrine factor that regulates endochondral bone development. PTH2R is potently activated by tuberoinfundibular peptide-39 (TIP-39), but not by PTHrP. PTH also strongly activates human PTH2R, but only weakly activates rat and zebrafish PTH2Rs, suggesting that TIP-39 is a natural ligand for PTH2R. Conversely, PTH3R binds and responds to both PTH and PTHrP, but not the TIP-39. The PTH family receptors are members of the B1 (or secretin-like) subfamily of class B GPCRs, which include receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), and calcitonin gene-related peptide. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways.


Pssm-ID: 320649 [Multi-domain]  Cd Length: 285  Bit Score: 76.50  E-value: 4.47e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 544 VGCSLSvlcLVATLVTFAVLSSVSTIRNQRYHIHANL--SFAVLVAQVLL-----------------LISFRLEPGTTP- 603
Cdd:cd15983   10 IGYSIS---LAALLVAVCILCYFKRLHCTRNYIHIHLfaSFICRAGSIFVkdavlysgtnegealdeKIEFGLSPGTRLq 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 604 ---CQVMAVLLHYFFLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLICIISLSFAMDSYGTsnNCWLSL 680
Cdd:cd15983   87 wvgCKVTVTLFLYFLATNHYWILVEGLYLHSLIFMAFLSDKNYLWALTIIGWGLPAVFVSVWASVRVSLADT--QCWDLS 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 681 ASGAIWAFVAPALFVIVVNIGILIAVTRVISQISADNYKIHGDP-SAFKLTAKAVAVLLPILGTSWV-FGVLA---VNGC 755
Cdd:cd15983  165 AGNLKWIYQVPILAAILVNFFLFLNIVRVLASKLWETNTGKLDPrQQYRKLLKSTLVLMPLFGVHYVlFMAMPytdVTGL 244
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 767973889 756 AVVFQYMFATL-NSLQGLFIFLFHCLLNSEVRAAFKhktKVW 796
Cdd:cd15983  245 LWQIQMHYEMLfNSSQGFFVAFIYCFCNGEVQAEIK---KAW 283
7tmB1_PTH2R cd15982
parathyroid hormone 2 receptor, member of the class B family of seven-transmembrane G ...
604-797 3.11e-14

parathyroid hormone 2 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors; The parathyroid hormone 2 receptor (PTH2R), one of the three subtypes of PTH receptor family, is found in mammals and fish, but not in chicken or frog. PTH2R is potently activated by tuberoinfundibular peptide-39 (TIP-39) but not by PTH-related peptide (PTHrP), a paracrine factor that regulates endochondral bone development. PTH, an endocrine hormone that regulates calcium homoeostasis and bone maintenance, strongly activates human PTH2R, but only weakly activates rat and zebrafish PTH2Rs. These results suggest that TIP-39 is a natural ligand for PTH2R. Conversely, PTH1R is activated by PTH and PTHrP, but not by TIP-39. The PTH family receptors are members of the B1 (or secretin-like) subfamily of class B GPCRs, which include receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), and calcitonin gene-related peptide. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways.


Pssm-ID: 320648 [Multi-domain]  Cd Length: 289  Bit Score: 74.20  E-value: 3.11e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 604 CQVMAVLLHYFFLSAFAWMLVEGLHLYSMVIKVFGSeDSKHRYYYGM-GWGFPLLIcIISLSFAMDSYGTSnNCWlSLAS 682
Cdd:cd15982   95 CKIAVVMFIYFLATNYYWILVEGLYLHSLIFVAFFS-DTKYLWGFTLiGWGFPAVF-VAAWAVVRATLADA-RCW-ELSA 170
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 683 GAI-WAFVAPALFVIVVNIGILIAVTRVI-SQISADNYKIHGDPSAFKLTAKAVAVLLPILGTSW-VFGVLAVNGCAVVF 759
Cdd:cd15982  171 GDIkWIYQAPILAAIGLNFILFLNTVRVLaTKIWETNAVGYDTRKQYRKLAKSTLVLVLVFGVHYiVFVCLPHTFTGLGW 250
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 767973889 760 QY-MFATL--NSLQGLFIFLFHCLLNSEVRAAFKhktKVWS 797
Cdd:cd15982  251 EIrMHCELffNSFQGFFVSIIYCYCNGEVQTEIK---KTWT 288
7tmB2_GPR124 cd15998
G protein-coupled receptor 124, member of the class B2 family of seven-transmembrane G ...
538-790 2.43e-13

G protein-coupled receptor 124, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR124 is an orphan receptor that has been classified as that belongs to the group III of adhesion GPCRs, which also includes orphan GPR123 and GPR125. GPR124, also known as tumor endothelial marker 5 (TEM5), is highly expressed in tumor vessels and in the vasculature of the developing embryo. GPR124 is essentially required for proper angiogenic sprouting into neural tissue, CNS-specific vascularization, and formation of the blood-brain barrier. GPR124 interacts with the PDZ domain of DLG1 (discs large homolog 1) through its PDZ-binding motif. Recently, studies of double-knockout mice showed that GPR124 functions as a co-activator of Wnt7a/Wnt7b-dependent beta-catenin signaling in brain endothelium. Moreover, WNT7-stimulated beta-catenin signaling is regulated by GPR124's intracellular PDZ binding motif and leucine-rich repeats (LRR) in its N-terminal extracellular domain. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320664 [Multi-domain]  Cd Length: 268  Bit Score: 71.14  E-value: 2.43e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 538 LSSISYVGCSLSVLCLVATLVTFAVLSSVSTIRNQRYHIHANLSFAVLVAQVLLLISFRLEPGTTPCQVMAVLLHYFFLS 617
Cdd:cd15998    4 LHPVVYPCTALLLLCLFSTIITYILNHSSIHVSRKGWHMLLNLCFHIAMTSAVFAGGITLTNYQMVCQAVGITLHYSSLS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 618 AFAWMLVEGLHLYSMVI-KVFGSEDSKH---------RYYYGMGwGFPLLICIISLSFAMDSYGTSNN-CWLsLASGAIW 686
Cdd:cd15998   84 TLLWMGVKARVLHKELTwRAPPPQEGDPalptprpmlRFYLIAG-GIPLIICGITAAVNIHNYRDHSPyCWL-VWRPSLG 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 687 AFVAPALFVIVVN-IGILIAVTRVISQiSADNYKIHgdpsAFKLTAKAVAVLLPILGTSWVFGVLAVNG---CAVVFQYM 762
Cdd:cd15998  162 AFYIPVALILLVTwIYFLCAGLHLRGP-SADGDSVY----SPGVQLGALVTTHFLYLAMWACGALAVSQrwlPRVVCSCL 236
                        250       260
                 ....*....|....*....|....*...
gi 767973889 763 FATLNSLQGLFIFLFHCLLNSEVRAAFK 790
Cdd:cd15998  237 YGVAASALGLFVFTHHCARRRDVRASWR 264
GPS pfam01825
GPCR proteolysis site, GPS, motif; The GPS motif is found in GPCRs, and is the site for ...
482-522 1.04e-11

GPCR proteolysis site, GPS, motif; The GPS motif is found in GPCRs, and is the site for auto-proteolysis, so is thus named, GPS. The GPS motif is a conserved sequence of ~40 amino acids containing canonical cysteine and tryptophan residues, and is the most highly conserved part of the domain. In most, if not all, cell-adhesion GPCRs these undergo autoproteolysis in the GPS between a conserved aliphatic residue (usually a leucine) and a threonine, serine, or cysteine residue. In higher eukaryotes this motif is found embedded in the C-terminal beta-stranded part of a GAIN domain - GPCR-Autoproteolysis INducing (GAIN). The GAIN-GPS domain adopts a fold in which the GPS motif, at the C-terminus, forms five beta-strands that are tightly integrated into the overall GAIN domain. The GPS motif, evolutionarily conserved from tetrahymena to mammals, is the only extracellular domain shared by all human cell-adhesion GPCRs and PKD proteins, and is the locus of multiple human disease mutations. The GAIN-GPS domain is both necessary and sufficient functionally for autoproteolysis, suggesting an autoproteolytic mechanism whereby the overall GAIN domain fine-tunes the chemical environment in the GPS to catalyze peptide bond hydrolysis. In the cell-adhesion GPCRs and PKD proteins, the GPS motif is always located at the end of their long N-terminal extracellular regions, immediately before the first transmembrane helix of the respective protein.


Pssm-ID: 460350  Cd Length: 44  Bit Score: 60.01  E-value: 1.04e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 767973889  482 CAFLDFS-SGEGVWSNHGCALTRGNLTYSVCRCTHLTNFAIL 522
Cdd:pfam01825   3 CVFWDFTnSTTGRWSTEGCTTVSLNDTHTVCSCNHLTSFAVL 44
GPS smart00303
G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin ...
480-527 1.91e-11

G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin REJ and polycystin.


Pssm-ID: 197639  Cd Length: 49  Bit Score: 59.71  E-value: 1.91e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 767973889   480 VYCAFldFSSGEGVWSNHGCALTRGNLTYSVCRCTHLTNFAILMQVVP 527
Cdd:smart00303   3 PICVF--WDESSGEWSTRGCELLETNGTHTTCSCNHLTTFAVLMDVPP 48
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
139-213 6.37e-11

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 61.25  E-value: 6.37e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767973889  139 WTHVLFTWkSKEGLKVYVNGTL--STSDPSGKVSRDYGesnvNLVIGSEQDqAKCYENGAFDEFIIWERALTPDEIA 213
Cdd:pfam13385  81 WTHVAVTY-DGGTLRLYVNGVLvgSSTLTGGPPPGTGG----PLYIGRSPG-GDDYFNGLIDEVRIYDRALSAAEIA 151
7tmB2_GPR125 cd15999
G protein-coupled receptor 125, member of the class B2 family of seven-transmembrane G ...
538-789 1.85e-09

G protein-coupled receptor 125, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR125 is an orphan receptor that has been classified as that belongs to the group III of adhesion GPCRs, which also includes orphan receptors GPR123 and GPR124. GPR125 directly interacts with dishevelled (Dvl) via its intracellular C-terminus, and together, GPR125 and Dvl recruit a subset of planar cell polarity (PCP) components into membrane subdomains, a prerequisite for activation of Wnt/PCP signaling. Thus, GPR125 influences the noncanonical WNT/PCP pathway, which does not involve beta-catenin, through interacting with and modulating the distribution of Dvl. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320665  Cd Length: 312  Bit Score: 59.88  E-value: 1.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 538 LSSISYVGCSLSVLCLVATLVTFAVLSSVSTIRNQRYHIHANLSFAVLVAQVLLLISFRLEPGTTPCQVMAVLLHYFFLS 617
Cdd:cd15999    4 LHPVVYATAVVLLLCLLTIIVSYIYHHSLVRISRKSWHMLVNLCFHIFLTCAVFVGGINQTRNASVCQAVGIILHYSTLA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 618 AFAWMLVEGLHLYSMVIKvfgsedSKHRY---------------YYGMGWGFPLLICIISLSFAMDSYGTSNN---CWLS 679
Cdd:cd15999   84 TVLWVGVTARNIYKQVTR------KAKRCqdpdeppppprpmlrFYLIGGGIPIIVCGITAAANIKNYGSRPNapyCWMA 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 680 LASgAIWAFVAPALFVIVVN----IGILIAVTR------VISQISADNYKI---------HGDPSAFKLTAKAVAVLL-- 738
Cdd:cd15999  158 WEP-SLGAFYGPAGFIIFVNcmyfLSIFIQLKRhperkyELKEPTEEQQRLaasehgelnHQDSGSSSASCSLVSTSAle 236
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767973889 739 -------PILGTS---------WVFGVLAVN---GCAVVFQYMF-ATLNSLqGLFIFLFHCLLNSEVRAAF 789
Cdd:cd15999  237 nehsfqaQLLGASlalflyvalWIFGALAVSlyyPMDLVFSCLFgATCLSL-GAFLVVHHCVNREDVRRAW 306
7tmE_cAMP_R_Slime_mold cd14940
slime mold cyclic AMP receptor, member of the class E family of seven-transmembrane G ...
581-785 2.34e-09

slime mold cyclic AMP receptor, member of the class E family of seven-transmembrane G protein-coupled receptors; This family represents the class E of seven-transmembrane G-protein coupled receptors found in soil-living amoebas, commonly referred to as slime molds. The class E family includes cAMP receptors (cAR1-4) and cAMP receptors-like proteins (CrlA-C) from Dictyostelium discoideum, and their highly homologous cAMP receptors (TasA and TasB) from Polysphondylium pallidum. So far, four subtypes of cAMP receptors (cAR1-4) have been identified that play an essential role in the detection and transmit of the periodic extracellular cAMP waves that regulate chemotactic cell movement during Dictyostelium development, from the unicellular amoeba aggregate into many multicellular slugs and then differentiate into a sporocarp, a fruiting body with cells specialized for different functions. These four subtypes differ in their expression levels and patterns during development. cAR1 is high-affinity receptor that is the first one to be expressed highly during early aggregation and continues to be expressed at low levels during later developmental stages. cAR1 detects extracellular cAMP and is coupled to G-alpha2 protein. Cells lacking cAR1 fail to aggregate, demonstrating that cAR1 is responsible for aggregation. During later aggregation the high-affinity cAR3 receptor is expressed at low levels. Nonetheless, cells lacking cAR3 do not show an obviously altered pattern of development and are still able to aggregate into fruiting bodies. In contrast, cAR2 and cAR4 are low affinity receptors expressed predominantly after aggregation in pre-stalk cells. cAR2 is essential for normal tip formation and deletion of the receptor arrests development at the mound stage. On the other hand, CAR4 regulates axial patterning and cellular differentiation, and deletion of the receptor results in defects during culmination. Furthermore, three cAMP receptor-like proteins (CrlA-C) were identified in Dictyostelium that show limited sequence similarity to the cAMP receptors. Of these CrlA is thought to be required for normal cell growth and tip formation in developing aggregates.


Pssm-ID: 320094 [Multi-domain]  Cd Length: 256  Bit Score: 58.90  E-value: 2.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 581 SFAVLVAQVLLLISFRLEPGTTPCQVMAVLLHYFFLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLICI 660
Cdd:cd14940   45 SLLKDIIYTMLTLTQSARPDGFLCYLYAIVITYGSLSCWLWTLCLAISIYLLIVKREPEPEKFEKYYHFVCWGLPLISTI 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 661 ISLSFamDSYG-TSNNCWLSLASGAIW--AFVAPALFVIVVNIGILIAVTRVISQIS----ADNYKIHGDpSAFKLTAKA 733
Cdd:cd14940  125 IMLIK--HHYGpVGNWCWIGNQYTGYRfgLFYGPFFIIFGISAVLVGLTSHYTYQVIhnwvSDNKDLHKT-YQFKLVNYI 201
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767973889 734 VAVLLpilgtSWVFGVlaVNGCAVVFQYMFATLNSLQGLFIFLfHCLLNSEV 785
Cdd:cd14940  202 IVFLL-----CWIFAV--INRIQNALNPFPFALNLLHTYLSPS-HGFYASVV 245
PTX cd00152
Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their ...
114-216 4.43e-06

Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated in innate immunity. CRP binds to ligands containing phosphocholine, SAP binds to amyloid fibrils, DNA, chromatin, fibronectin, C4-binding proteins and glycosaminoglycans. "Long" pentraxins have N-terminal extensions to the common pentraxin domain; one group, the neuronal pentraxins, may be involved in synapse formation and remodeling, and they may also be able to form heteromultimers.


Pssm-ID: 238086  Cd Length: 201  Bit Score: 48.42  E-value: 4.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 114 TLLYYGRYNSSC---ISKPEQ---CGPEGPYWTHVLFTWKSKEGL-KVYVNGTLStsdPSGKVSRDY--GESNVnLVIGS 184
Cdd:cd00152   61 ELLLYKEKDGGYslyIGGKEVtfkVPESDGAWHHICVTWESTSGIaELWVNGKLS---VRKSLKKGYtvGPGGS-IILGQ 136
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 767973889 185 EQDQAkcyeNGAFDE----------FIIWERALTPDEIAMYF 216
Cdd:cd00152  137 EQDSY----GGGFDAtqsfvgeisdVNMWDSVLSPEEIKNVY 174
PTX smart00159
Pentraxin / C-reactive protein / pentaxin family; This family form a doscoid pentameric ...
139-219 1.45e-05

Pentraxin / C-reactive protein / pentaxin family; This family form a doscoid pentameric structure. Human serum amyloid P demonstrates calcium-mediated ligand-binding.


Pssm-ID: 128463  Cd Length: 206  Bit Score: 46.88  E-value: 1.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889   139 WTHVLFTWKSKEGL-KVYVNGTLSTsdpsGKVS-RDYG-ESNVNLVIGSEQDqakCYeNGAFD----------EFIIWER 205
Cdd:smart00159  92 WHHICTTWESSSGIaELWVDGKPGV----RKGLaKGYTvKPGGSIILGQEQD---SY-GGGFDatqsfvgeigDLNMWDS 163
                           90
                   ....*....|....
gi 767973889   206 ALTPDEIAMYFTAA 219
Cdd:smart00159 164 VLSPEEIKSVYKGS 177
Dicty_CAR pfam05462
Slime mold cyclic AMP receptor; This family consists of cyclic AMP receptor (CAR) proteins ...
600-754 7.67e-05

Slime mold cyclic AMP receptor; This family consists of cyclic AMP receptor (CAR) proteins from slime molds. CAR proteins are responsible for controlling development in Dictyostelium discoideum.


Pssm-ID: 283188  Cd Length: 305  Bit Score: 45.55  E-value: 7.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889  600 GTTPCQVMAVLLHYFFLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLICIISLSFAMDSYgTSNNCWLS 679
Cdd:pfam05462  72 GGFPCYLYAIVITYGSLACWLWTLCLAFSIYNLIVKREPEPEKFEKYYFFVCWGLPLISTIVMLSKDTIEF-VGNWCWIG 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889  680 LA-SGAIWAFVAPALFVIVVNIGILIAVT-----RVISQISADNYKIHGDpSAFKLTAKAVAVLLpilgtSWVFGVL--A 751
Cdd:pfam05462 151 EQyTGYRFGLFYGPFFAIWGISAVLVGLTsrytySVIRNSVSDNKDKHMT-YQFKLINYIIVFLV-----CWVFAVVnrI 224

                  ...
gi 767973889  752 VNG 754
Cdd:pfam05462 225 LNG 227
7tmF_FZD3_FZD6-like cd15910
class F frizzled subfamilies 3, 6 and related proteins; member of 7-transmembrane G ...
538-705 9.96e-05

class F frizzled subfamilies 3, 6 and related proteins; member of 7-transmembrane G protein-coupled receptors; This group includes subfamilies 3 and 6 of the frizzled (FZD) family of seven transmembrane-spanning proteins, which constitute a novel and separate class of GPCRs, and their closely related proteins. This class F protein family consists of 10 isoforms (FZD1-10) in mammals. The FZDs are activated by the wingless/int-1 (WNT) family of secreted lipoglycoproteins and preferentially couple to stimulatory G proteins of the Gs family, which activate adenylate cyclase, but can also couple to G proteins of the Gi/Gq families. In the WNT/beta-catenin signaling pathway, the WNT ligand binds to FZD and a lipoprotein receptor-related protein (LRP) co-receptor. This leads to the stabilization and translocation of beta-catenin to the nucleus, where it induces the activation of TCF/LEF family transcription factors. The conserved cytoplasmic motif of FZD, Lys-Thr-X-X-X-Trp, is required for activation of the WNT/beta-catenin pathway, and for membrane localization and phosphorylation of Dsh (dishevelled) protein, a key component of the WNT pathway that relays the WNT signals from the activated receptor to downstream effector proteins. The WNT pathway plays a critical role in many developmental processes, such as cell-fate determination, cell proliferation, neural patterning, stem cell renewal, tissue homeostasis and repair, and tumorigenesis, among many others.


Pssm-ID: 320576  Cd Length: 321  Bit Score: 45.23  E-value: 9.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 538 LSSISYVGCSLSVLCLVATLVTFavLSSVSTIRNQRYHIHANLSFAV--LVAQVLLLISFRLE----------------- 598
Cdd:cd15910    8 LMFARYFIGVVSILCLLATLFTF--LTFLIDVNRFRYPERPIIFYAVcyFVVSLIFFVGFLLGddvacnhaimdenngat 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 599 ----PGTTPCQVMAVLLHYFFLSAFAWMLVEGLHLYSMVIKVFGSE--DSKHRYYYGMGWGFPLLICIISLSF-AMDSYG 671
Cdd:cd15910   86 vvegSRNKACTILFMILYFFTMAGTVWWVILTITWFLAAGFKWGSEaiEKKALYFHALAWGIPGVLTMVLLATnKIEGDN 165
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 767973889 672 TSNNCWLSL--ASGAIWAFVAPALFVIVVNIGILIA 705
Cdd:cd15910  166 ISGVCFVGLydSDGLRFFVLLPLCLYVLVGMSLLLA 201
7tmF_FZD3 cd15033
class F frizzled subfamily 3, member of 7-transmembrane G protein-coupled receptors; This ...
548-705 3.20e-04

class F frizzled subfamily 3, member of 7-transmembrane G protein-coupled receptors; This group includes subfamily 3 of the frizzled (FZD) family of seven transmembrane-spanning proteins, which constitute a novel and separate class of GPCRs, and its closely related proteins. This class F protein family consists of 10 isoforms (FZD1-10) in mammals. The FZDs are activated by the wingless/int-1 (WNT) family of secreted lipoglycoproteins and preferentially couple to stimulatory G proteins of the Gs family, which activate adenylate cyclase, but can also couple to G proteins of the Gi/Gq families. In the WNT/beta-catenin signaling pathway, the WNT ligand binds to FZD and a lipoprotein receptor-related protein (LRP) co-receptor. This leads to the stabilization and translocation of beta-catenin to the nucleus, where it induces the activation of TCF/LEF family transcription factors. The conserved cytoplasmic motif of FZD, Lys-Thr-X-X-X-Trp, is required for activation of the WNT/beta-catenin pathway, and for membrane localization and phosphorylation of Dsh (dishevelled) protein, a key component of the WNT pathway that relays the WNT signals from the activated receptor to downstream effector proteins. The WNT pathway plays a critical role in many developmental processes, such as cell-fate determination, cell proliferation, neural patterning, stem cell renewal, tissue homeostasis and repair, and tumorigenesis, among many others.


Pssm-ID: 320161  Cd Length: 321  Bit Score: 43.78  E-value: 3.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 548 LSVLCLVATLVTFavLSSVSTIRNQRYHIHANLSFAV--LVAQVLLLISFRLE---------PG------------TTPC 604
Cdd:cd15033   18 ISIVCLSATLFTF--LTFLIDVTRFRYPERPIIFYAVcyMMVSLIFFIGFLLEdrvacnaasPGqykastvtqgshNKAC 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889 605 QVMAVLLHYFFLSAFAWMLVEGLHLYSMVIKVFGSE--DSKHRYYYGMGWGFPLLICIISLSF-AMDSYGTSNNCWLSL- 680
Cdd:cd15033   96 TMLFMVLYFFTMAGSVWWVILTITWFLAAVPKWGSEaiEKKALLFHASAWGIPGTLTIILLAMnKIEGDNISGVCFVGLy 175
                        170       180
                 ....*....|....*....|....*.
gi 767973889 681 -ASGAIWAFVAPALFVIVVNIGILIA 705
Cdd:cd15033  176 dVDALRYFVLAPLCLDVVVGVSLLLA 201
Pentaxin pfam00354
Pentaxin family; Pentaxins are also known as pentraxins.
72-212 1.52e-03

Pentaxin family; Pentaxins are also known as pentraxins.


Pssm-ID: 278768  Cd Length: 194  Bit Score: 40.48  E-value: 1.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973889   72 LPSRNATFVYSndsAYSNLSATVDI----VEGKVNKGIYLKEEKGVTLLYYGryNSSCISKpeQCgPEGPYWTHVLFTWK 147
Cdd:pfam00354  22 KPLQNFTLCLR---FYTDLSRSYSLfsyaTKKQDNELLIFKEKDGEYSFYVG--GAEVLFK--VS-EIPVAPVHICTSWE 93
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767973889  148 SKEGL-KVYVNGTLSTSDPSGKVSRDYGESNVnlVIGSEQD------QAKCYENGAFDEFIIWERALTPDEI 212
Cdd:pfam00354  94 SSSGIaEFWVDGKPWVRKSLKKGYTVGAPPSI--ILGQEQDsygggfDASQSLVGEIGDLNMWDYVLTPEEI 163
7tmF_Frizzled_SMO cd13951
class F frizzled/smoothened family, member of the 7-transmembrane G protein-coupled receptor ...
600-663 5.55e-03

class F frizzled/smoothened family, member of the 7-transmembrane G protein-coupled receptor superfamily; The class F G protein-coupled receptors includes the frizzled (FZD) family of seven-transmembrane proteins consisting of 10 isoforms (FZD1-10) in mammals. The FZDs are activated by the wingless/int-1 (WNT) family of secreted lipoglycoproteins and preferentially couple to stimulatory G proteins of the Gs family, which activate adenylate cyclase, but can also couple to G proteins of the Gi/Gq families. In the WNT/beta-catenin signaling pathway, the WNT ligand binds to FZD and a lipoprotein receptor-related protein (LRP) co-receptor. This leads to the stabilization and translocation of beta-catenin to the nucleus, where it induces the activation of TCF/LEF family transcription factors. The conserved cytoplasmic motif of FZD, Lys-Thr-X-X-X-Trp, is required for activation of the WNT/beta-catenin pathway, and for membrane localization and phosphorylation of Dsh (dishevelled) protein, a key component of the WNT pathway that relays the WNT signals from the activated receptor to downstream effector proteins. Also included in the class F family is the closely related smoothened (SMO), which is a transmembrane G protein-coupled receptor that acts as the transducer of the hedgehog (HH) signaling pathway. SMO is activated by the hedgehog (HH) family of proteins acting on the 12-transmembrane domain receptor patched (PTCH), which constitutively inhibits SMO. Thus, in the absence of HH proteins, PTCH inhibits SMO signaling. On the other hand, binding of HH to the PTCH receptor activates its internalization and degradation, thereby releasing the PTCH inhibition of SMO. This allows SMO to trigger intracellular signaling and the subsequent activation of the Gli family of zinc finger transcriptional factors and induction of HH target gene expression (PTCH, Gli1, cyclin, Bcl-2, etc). The WNT and HH signaling pathways play critical roles in many developmental processes, such as cell-fate determination, cell proliferation, neural patterning, stem cell renewal, tissue homeostasis and repair, and tumorigenesis, among many others.


Pssm-ID: 320089  Cd Length: 314  Bit Score: 39.61  E-value: 5.55e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767973889 600 GTTPCQVMAVLLHYFFLSAFAWMLVEGLHLYSMVIKVFGSE--DSKHRYYYGMGWGFPLLICIISL 663
Cdd:cd13951   90 GNAPCAIVFLLTYYFGMAASIWWVILTLTWFLSAGLKWSSEaiEKKSSYFHLVAWGLPAVLTIAVL 155
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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