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Conserved domains on  [gi|767974935|ref|XP_011536900|]
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probable ATP-dependent RNA helicase DHX37 isoform X3 [Homo sapiens]

Protein Classification

DEAD/DEAH box helicase( domain architecture ID 1000776)

DEAD/DEAH box containing ATP-dependent helicase catalyzes the unwinding of DNA or RNA; similar to ATP-dependent RNA helicase that is involved in translation initiation

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
HrpA super family cl34328
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
252-830 1.03e-122

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG1643:

Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 391.75  E-value: 1.03e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 252 LPI---LSEeqvIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEDSIIgVTEPRRVAAVAMSQRVAKEMN--LSQ 326
Cdd:COG1643   10 LPVsavLPE---LLAALRAHQVVVLAAPPGAGKTTQLPLALLELGWGAGGRIG-MLEPRRLAARAAAERMAEELGepVGE 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 327 RVvSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIvtLRAKRnlP-LKLL 405
Cdd:COG1643   86 TV-GYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDL--QPALR--PdLKLL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 406 IMSATLRVEDFTqnpRLFAkPPPVIKVESRQFPVTVHFNKRTPLE-DYSGECFRKVCKIHRMlPAGGILVFLTGQAEVHA 484
Cdd:COG1643  161 VMSATLDAERFA---RLLG-DAPVIESSGRTYPVEVRYRPLPADErDLEDAVADAVREALAE-EPGDILVFLPGEREIRR 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 485 LCRRLRKAFPPSrarpqekdddqkdsveemrkfkksrarakkaraevlpqinldhysvlpagegdedreaevdeeegald 564
Cdd:COG1643  236 TAEALRGRLPPD-------------------------------------------------------------------- 247
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 565 sdldldlgdggqdggeqpdaslpLHVLPLYSLLAPEKQAQVFKPPPEGTRLCVVATNVAETSLTIPGIKYVVDCGKVKKR 644
Cdd:COG1643  248 -----------------------TEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIP 304
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 645 YYDRVTGVSSFRVTWVSQASADQRAGRAGRTEPGHCYRLYSSAVFGDFEQFPPPEITRrpvEDL---ILQMKALNVEKVI 721
Cdd:COG1643  305 RYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILR---ADLaslILELAAWGLGDPE 381
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 722 NFPFPTPPSveallaaeelliaLGALqppqkAERVKQLQE-------NRlscpITALGRTMATFPVAPRYAKMLALSRQH 794
Cdd:COG1643  382 DLPFLDPPP-------------ARAI-----ADARALLQElgaldadGR----LTPLGRALARLPLDPRLARMLLAAAEL 439
                        570       580       590
                 ....*....|....*....|....*....|....*.
gi 767974935 795 GCLPYAITIVASMTVRELFeeldRPAASDEELTRLK 830
Cdd:COG1643  440 GCLREAAILAALLSERDPR----RGAAGSDLLARLN 471
 
Name Accession Description Interval E-value
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
252-830 1.03e-122

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 391.75  E-value: 1.03e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 252 LPI---LSEeqvIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEDSIIgVTEPRRVAAVAMSQRVAKEMN--LSQ 326
Cdd:COG1643   10 LPVsavLPE---LLAALRAHQVVVLAAPPGAGKTTQLPLALLELGWGAGGRIG-MLEPRRLAARAAAERMAEELGepVGE 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 327 RVvSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIvtLRAKRnlP-LKLL 405
Cdd:COG1643   86 TV-GYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDL--QPALR--PdLKLL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 406 IMSATLRVEDFTqnpRLFAkPPPVIKVESRQFPVTVHFNKRTPLE-DYSGECFRKVCKIHRMlPAGGILVFLTGQAEVHA 484
Cdd:COG1643  161 VMSATLDAERFA---RLLG-DAPVIESSGRTYPVEVRYRPLPADErDLEDAVADAVREALAE-EPGDILVFLPGEREIRR 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 485 LCRRLRKAFPPSrarpqekdddqkdsveemrkfkksrarakkaraevlpqinldhysvlpagegdedreaevdeeegald 564
Cdd:COG1643  236 TAEALRGRLPPD-------------------------------------------------------------------- 247
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 565 sdldldlgdggqdggeqpdaslpLHVLPLYSLLAPEKQAQVFKPPPEGTRLCVVATNVAETSLTIPGIKYVVDCGKVKKR 644
Cdd:COG1643  248 -----------------------TEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIP 304
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 645 YYDRVTGVSSFRVTWVSQASADQRAGRAGRTEPGHCYRLYSSAVFGDFEQFPPPEITRrpvEDL---ILQMKALNVEKVI 721
Cdd:COG1643  305 RYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILR---ADLaslILELAAWGLGDPE 381
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 722 NFPFPTPPSveallaaeelliaLGALqppqkAERVKQLQE-------NRlscpITALGRTMATFPVAPRYAKMLALSRQH 794
Cdd:COG1643  382 DLPFLDPPP-------------ARAI-----ADARALLQElgaldadGR----LTPLGRALARLPLDPRLARMLLAAAEL 439
                        570       580       590
                 ....*....|....*....|....*....|....*.
gi 767974935 795 GCLPYAITIVASMTVRELFeeldRPAASDEELTRLK 830
Cdd:COG1643  440 GCLREAAILAALLSERDPR----RGAAGSDLLARLN 471
DEXHc_DHX37 cd17982
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ...
252-432 4.34e-120

DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350740 [Multi-domain]  Cd Length: 191  Bit Score: 362.44  E-value: 4.34e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEDS----IIGVTEPRRVAAVAMSQRVAKEMNLSQR 327
Cdd:cd17982    1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFGSPESdnpgMIGITQPRRVAAVSMAKRVAEELNVFGK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 328 VVSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAK------RNLP 401
Cdd:cd17982   81 EVSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKlylqdqTVKP 160
                        170       180       190
                 ....*....|....*....|....*....|.
gi 767974935 402 LKLLIMSATLRVEDFTQNPRLFAKPPPVIKV 432
Cdd:cd17982  161 LKLVIMSATLRVEDFTENKLLFPRPPPVIKV 191
DEAH_box_HrpA TIGR01967
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ...
252-843 2.43e-88

RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273900 [Multi-domain]  Cd Length: 1283  Bit Score: 306.69  E-value: 2.43e-88
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935   252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEdSIIGVTEPRRVAAVAMSQRVAKEMNLS-QRVVS 330
Cdd:TIGR01967   66 LPVSAKREDIAEAIAENQVVIIAGETGSGKTTQLPKICLELGRGSH-GLIGHTQPRRLAARTVAQRIAEELGTPlGEKVG 144
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935   331 YQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVtlraKRNLPLKLLIMSAT 410
Cdd:TIGR01967  145 YKVRFHDQVSSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLL----PRRPDLKIIITSAT 220
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935   411 LRVEDFTqnpRLFAKpPPVIKVESRQFPVTVHFNkrtPLEDYSGE--------CFRKVCKIHRMLPaGGILVFLTGQAEV 482
Cdd:TIGR01967  221 IDPERFS---RHFNN-APIIEVSGRTYPVEVRYR---PLVEEQEDddldqleaILDAVDELFAEGP-GDILIFLPGEREI 292
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935   483 halcrrlrkafppsrarpqekdddqKDSVEEMRKfkksrarakkaraevlpqINLDHysvlpagegdedreaevdeeega 562
Cdd:TIGR01967  293 -------------------------RDAAEILRK------------------RNLRH----------------------- 306
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935   563 ldsdldldlgdggqdggeqpdaslpLHVLPLYSLLAPEKQAQVFKppPEGTRLCVVATNVAETSLTIPGIKYVVDCGKVK 642
Cdd:TIGR01967  307 -------------------------TEILPLYARLSNKEQQRVFQ--PHSGRRIVLATNVAETSLTVPGIHYVIDTGTAR 359
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935   643 KRYYDRVTGVSSFRVTWVSQASADQRAGRAGRTEPGHCYRLYSSAVFGDFEQFPPPEITRRPVEDLILQMKALNVEKVIN 722
Cdd:TIGR01967  360 ISRYSYRTKVQRLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNSRPEFTDPEILRTNLASVILQMLALRLGDIAA 439
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935   723 FPFPTPPSVEALLAAEELLIALGAlqppqkaervkqLQENRLSCPITALGRTMATFPVAPRYAKMLALSRQHGCLPYAIT 802
Cdd:TIGR01967  440 FPFIEAPDPRAIRDGFRLLEELGA------------LDDDEAEPQLTPIGRQLAQLPVDPRLARMLLEAHRLGCLQEVLI 507
                          570       580       590       600
                   ....*....|....*....|....*....|....*....|..
gi 767974935   803 IVASMTVRELFEE-LDRPAASDEELTRLKSKRARVAQMKRTW 843
Cdd:TIGR01967  508 IASALSIQDPRERpMEKQQAADQAHARFKDPRSDFLSRVNLW 549
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
252-832 1.70e-87

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 304.68  E-value: 1.70e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935  252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEdSIIGVTEPRRVAAVAMSQRVAKEMNLS-QRVVS 330
Cdd:PRK11131   73 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLELGRGVK-GLIGHTQPRRLAARTVANRIAEELETElGGCVG 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935  331 YQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKrnlpLKLLIMSAT 410
Cdd:PRK11131  152 YKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPD----LKVIITSAT 227
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935  411 LRVEDFTqnpRLFAKpPPVIKVESRQFPVTVHFNKRTPLEDYSGE-----CFRKVCKIHRMLPaGGILVFLTGQAEVhal 485
Cdd:PRK11131  228 IDPERFS---RHFNN-APIIEVSGRTYPVEVRYRPIVEEADDTERdqlqaIFDAVDELGREGP-GDILIFMSGEREI--- 299
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935  486 crrlrkafppsrarpqekdddqKDSveemrkfkksrarakkarAEVLPQINLDHysvlpagegdedreaevdeeegalds 565
Cdd:PRK11131  300 ----------------------RDT------------------ADALNKLNLRH-------------------------- 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935  566 dldldlgdggqdggeqpdaslpLHVLPLYSLLAPEKQAQVFKppPEGTRLCVVATNVAETSLTIPGIKYVVDCGKVKKRY 645
Cdd:PRK11131  314 ----------------------TEILPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISR 369
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935  646 YDRVTGVSSFRVTWVSQASADQRAGRAGRTEPGHCYRLYSSAVFGDFEQFPPPEITRRPVEDLILQMKALNVEKVINFPF 725
Cdd:PRK11131  370 YSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAFPF 449
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935  726 PTPPSVEALLAAEELLIALGALQPPQKaERVKQLqenrlscpiTALGRTMATFPVAPRYAKMLALSRQHGCLPYAITIVA 805
Cdd:PRK11131  450 VEAPDKRNIQDGVRLLEELGAITTDEQ-ASAYKL---------TPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITS 519
                         570       580
                  ....*....|....*....|....*...
gi 767974935  806 SMTVRELFEE-LDRPAASDEELTRLKSK 832
Cdd:PRK11131  520 ALSIQDPRERpMDKQQASDEKHRRFADK 547
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
768-858 4.73e-26

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 103.09  E-value: 4.73e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935  768 ITALGRTMATFPVAPRYAKMLALSRQHGCLPYAITIVASMTVRELFEELDRPAASDEELTRLKSKRARVAQMKRTWAGQG 847
Cdd:pfam04408  17 LTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFLDPRSAAKAARRRRRAADEKARAKFARLD 96
                          90
                  ....*....|.
gi 767974935  848 aslKLGDLMVL 858
Cdd:pfam04408  97 ---LEGDHLTL 104
DEXDc smart00487
DEAD-like helicases superfamily;
258-418 4.19e-24

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 101.03  E-value: 4.19e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935   258 EQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEDSIIGVTEPRRVAAVAMSQRVAKEMNLSQRVV-------S 330
Cdd:smart00487  14 KEAIEALLSGLRDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVvglyggdS 93
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935   331 YQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLL-RYKVVIIDEAHERS--VYTDILIGLLSRIvtlrakrNLPLKLLIM 407
Cdd:smart00487  94 KREQLRKLESGKTDILVTTPGRLLDLLENDKLSLsNVDLVILDEAHRLLdgGFGDQLEKLLKLL-------PKNVQLLLL 166
                          170
                   ....*....|...
gi 767974935   408 SATL--RVEDFTQ 418
Cdd:smart00487 167 SATPpeEIENLLE 179
 
Name Accession Description Interval E-value
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
252-830 1.03e-122

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 391.75  E-value: 1.03e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 252 LPI---LSEeqvIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEDSIIgVTEPRRVAAVAMSQRVAKEMN--LSQ 326
Cdd:COG1643   10 LPVsavLPE---LLAALRAHQVVVLAAPPGAGKTTQLPLALLELGWGAGGRIG-MLEPRRLAARAAAERMAEELGepVGE 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 327 RVvSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIvtLRAKRnlP-LKLL 405
Cdd:COG1643   86 TV-GYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDL--QPALR--PdLKLL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 406 IMSATLRVEDFTqnpRLFAkPPPVIKVESRQFPVTVHFNKRTPLE-DYSGECFRKVCKIHRMlPAGGILVFLTGQAEVHA 484
Cdd:COG1643  161 VMSATLDAERFA---RLLG-DAPVIESSGRTYPVEVRYRPLPADErDLEDAVADAVREALAE-EPGDILVFLPGEREIRR 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 485 LCRRLRKAFPPSrarpqekdddqkdsveemrkfkksrarakkaraevlpqinldhysvlpagegdedreaevdeeegald 564
Cdd:COG1643  236 TAEALRGRLPPD-------------------------------------------------------------------- 247
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 565 sdldldlgdggqdggeqpdaslpLHVLPLYSLLAPEKQAQVFKPPPEGTRLCVVATNVAETSLTIPGIKYVVDCGKVKKR 644
Cdd:COG1643  248 -----------------------TEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIP 304
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 645 YYDRVTGVSSFRVTWVSQASADQRAGRAGRTEPGHCYRLYSSAVFGDFEQFPPPEITRrpvEDL---ILQMKALNVEKVI 721
Cdd:COG1643  305 RYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILR---ADLaslILELAAWGLGDPE 381
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 722 NFPFPTPPSveallaaeelliaLGALqppqkAERVKQLQE-------NRlscpITALGRTMATFPVAPRYAKMLALSRQH 794
Cdd:COG1643  382 DLPFLDPPP-------------ARAI-----ADARALLQElgaldadGR----LTPLGRALARLPLDPRLARMLLAAAEL 439
                        570       580       590
                 ....*....|....*....|....*....|....*.
gi 767974935 795 GCLPYAITIVASMTVRELFeeldRPAASDEELTRLK 830
Cdd:COG1643  440 GCLREAAILAALLSERDPR----RGAAGSDLLARLN 471
DEXHc_DHX37 cd17982
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ...
252-432 4.34e-120

DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350740 [Multi-domain]  Cd Length: 191  Bit Score: 362.44  E-value: 4.34e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEDS----IIGVTEPRRVAAVAMSQRVAKEMNLSQR 327
Cdd:cd17982    1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFGSPESdnpgMIGITQPRRVAAVSMAKRVAEELNVFGK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 328 VVSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAK------RNLP 401
Cdd:cd17982   81 EVSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKlylqdqTVKP 160
                        170       180       190
                 ....*....|....*....|....*....|.
gi 767974935 402 LKLLIMSATLRVEDFTQNPRLFAKPPPVIKV 432
Cdd:cd17982  161 LKLVIMSATLRVEDFTENKLLFPRPPPVIKV 191
DEAH_box_HrpA TIGR01967
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ...
252-843 2.43e-88

RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273900 [Multi-domain]  Cd Length: 1283  Bit Score: 306.69  E-value: 2.43e-88
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935   252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEdSIIGVTEPRRVAAVAMSQRVAKEMNLS-QRVVS 330
Cdd:TIGR01967   66 LPVSAKREDIAEAIAENQVVIIAGETGSGKTTQLPKICLELGRGSH-GLIGHTQPRRLAARTVAQRIAEELGTPlGEKVG 144
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935   331 YQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVtlraKRNLPLKLLIMSAT 410
Cdd:TIGR01967  145 YKVRFHDQVSSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLL----PRRPDLKIIITSAT 220
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935   411 LRVEDFTqnpRLFAKpPPVIKVESRQFPVTVHFNkrtPLEDYSGE--------CFRKVCKIHRMLPaGGILVFLTGQAEV 482
Cdd:TIGR01967  221 IDPERFS---RHFNN-APIIEVSGRTYPVEVRYR---PLVEEQEDddldqleaILDAVDELFAEGP-GDILIFLPGEREI 292
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935   483 halcrrlrkafppsrarpqekdddqKDSVEEMRKfkksrarakkaraevlpqINLDHysvlpagegdedreaevdeeega 562
Cdd:TIGR01967  293 -------------------------RDAAEILRK------------------RNLRH----------------------- 306
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935   563 ldsdldldlgdggqdggeqpdaslpLHVLPLYSLLAPEKQAQVFKppPEGTRLCVVATNVAETSLTIPGIKYVVDCGKVK 642
Cdd:TIGR01967  307 -------------------------TEILPLYARLSNKEQQRVFQ--PHSGRRIVLATNVAETSLTVPGIHYVIDTGTAR 359
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935   643 KRYYDRVTGVSSFRVTWVSQASADQRAGRAGRTEPGHCYRLYSSAVFGDFEQFPPPEITRRPVEDLILQMKALNVEKVIN 722
Cdd:TIGR01967  360 ISRYSYRTKVQRLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNSRPEFTDPEILRTNLASVILQMLALRLGDIAA 439
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935   723 FPFPTPPSVEALLAAEELLIALGAlqppqkaervkqLQENRLSCPITALGRTMATFPVAPRYAKMLALSRQHGCLPYAIT 802
Cdd:TIGR01967  440 FPFIEAPDPRAIRDGFRLLEELGA------------LDDDEAEPQLTPIGRQLAQLPVDPRLARMLLEAHRLGCLQEVLI 507
                          570       580       590       600
                   ....*....|....*....|....*....|....*....|..
gi 767974935   803 IVASMTVRELFEE-LDRPAASDEELTRLKSKRARVAQMKRTW 843
Cdd:TIGR01967  508 IASALSIQDPRERpMEKQQAADQAHARFKDPRSDFLSRVNLW 549
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
252-832 1.70e-87

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 304.68  E-value: 1.70e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935  252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEdSIIGVTEPRRVAAVAMSQRVAKEMNLS-QRVVS 330
Cdd:PRK11131   73 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLELGRGVK-GLIGHTQPRRLAARTVANRIAEELETElGGCVG 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935  331 YQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKrnlpLKLLIMSAT 410
Cdd:PRK11131  152 YKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPD----LKVIITSAT 227
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935  411 LRVEDFTqnpRLFAKpPPVIKVESRQFPVTVHFNKRTPLEDYSGE-----CFRKVCKIHRMLPaGGILVFLTGQAEVhal 485
Cdd:PRK11131  228 IDPERFS---RHFNN-APIIEVSGRTYPVEVRYRPIVEEADDTERdqlqaIFDAVDELGREGP-GDILIFMSGEREI--- 299
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935  486 crrlrkafppsrarpqekdddqKDSveemrkfkksrarakkarAEVLPQINLDHysvlpagegdedreaevdeeegalds 565
Cdd:PRK11131  300 ----------------------RDT------------------ADALNKLNLRH-------------------------- 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935  566 dldldlgdggqdggeqpdaslpLHVLPLYSLLAPEKQAQVFKppPEGTRLCVVATNVAETSLTIPGIKYVVDCGKVKKRY 645
Cdd:PRK11131  314 ----------------------TEILPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISR 369
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935  646 YDRVTGVSSFRVTWVSQASADQRAGRAGRTEPGHCYRLYSSAVFGDFEQFPPPEITRRPVEDLILQMKALNVEKVINFPF 725
Cdd:PRK11131  370 YSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAFPF 449
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935  726 PTPPSVEALLAAEELLIALGALQPPQKaERVKQLqenrlscpiTALGRTMATFPVAPRYAKMLALSRQHGCLPYAITIVA 805
Cdd:PRK11131  450 VEAPDKRNIQDGVRLLEELGAITTDEQ-ASAYKL---------TPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITS 519
                         570       580
                  ....*....|....*....|....*...
gi 767974935  806 SMTVRELFEE-LDRPAASDEELTRLKSK 832
Cdd:PRK11131  520 ALSIQDPRERpMDKQQASDEKHRRFADK 547
DEXHc_RHA-like cd17917
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ...
268-432 6.26e-66

DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438707 [Multi-domain]  Cd Length: 159  Bit Score: 217.33  E-value: 6.26e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 268 HPIVIVCGETGSGKTTQVPQFLYEAGFSS-EDSIIGVTEPRRVAAVAMSQRVAKEMNLS-QRVVSYQIRYEGNVTEETRI 345
Cdd:cd17917    1 NQVVVIVGETGSGKTTQVPQFLLEDGLAKgGKGRIVCTQPRRIAAISVAERVAEERGEKlGEEVGYQIRFESKTSSKTRI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 346 KFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVtlraKRNLPLKLLIMSATLRVEDFTQnprlFAK 425
Cdd:cd17917   81 KFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLL----RKRPDLKVILMSATLDAEKFSS----YFG 152

                 ....*..
gi 767974935 426 PPPVIKV 432
Cdd:cd17917  153 GAPVIHI 159
DEXHc_DHX33 cd17978
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ...
252-418 3.45e-64

DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438710 [Multi-domain]  Cd Length: 178  Bit Score: 213.37  E-value: 3.45e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSsEDSIIGVTEPRRVAAVAMSQRVAKEMN--LSQrVV 329
Cdd:cd17978    1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGFA-RGGMIGITQPRRVAAVSVAKRVAEEMGveLGQ-LV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 330 SYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKRNL-PLKLLIMS 408
Cdd:cd17978   79 GYSVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRKEQKLsPLKVIIMS 158
                        170
                 ....*....|
gi 767974935 409 ATLRVEDFTQ 418
Cdd:cd17978  159 ATLDADLFSE 168
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
437-684 1.33e-59

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 200.45  E-value: 1.33e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 437 FPVTVHFNKRT----------PLEDYSGECFRKVCKIHRMLPAGGILVFLTGQAEVHALCRRLRKafppsraRPQEKDdd 506
Cdd:cd18791    1 FPVEVYYLEDIlellgissekEDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELLRE-------ELLSPD-- 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 507 qkdsveemrkfkksrarakkaraevlpqinldhysvlpagegdedreaevdeeegaldsdldldlgdggqdggeqpdaSL 586
Cdd:cd18791   72 ------------------------------------------------------------------------------LG 73
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 587 PLHVLPLYSLLAPEKQAQVFKPPPEGTRLCVVATNVAETSLTIPGIKYVVDCGKVKKRYYDRVTGVSSFRVTWVSQASAD 666
Cdd:cd18791   74 KLLVLPLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAE 153
                        250
                 ....*....|....*...
gi 767974935 667 QRAGRAGRTEPGHCYRLY 684
Cdd:cd18791  154 QRAGRAGRTRPGKCYRLY 171
DEXHc_DHX40 cd17984
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ...
252-414 1.07e-53

DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350742 [Multi-domain]  Cd Length: 178  Bit Score: 184.67  E-value: 1.07e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSsEDSIIGVTEPRRVAAVAMSQRVAKEMNLS-QRVVS 330
Cdd:cd17984    1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFS-QHGMIGVTQPRRVAAISVAQRVAEEMKCTlGSKVG 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 331 YQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKRN-LPLKLLIMSA 409
Cdd:cd17984   80 YQVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFQEKSPNRkEHLKVVVMSA 159

                 ....*
gi 767974935 410 TLRVE 414
Cdd:cd17984  160 TLELA 164
DEXHc_DHX35 cd17980
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ...
252-416 2.55e-52

DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350738 [Multi-domain]  Cd Length: 185  Bit Score: 180.74  E-value: 2.55e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEDSIIGVTEPRRVAAVAMSQRVAKEM--NLSQRvV 329
Cdd:cd17980    1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEAGWTAGGRVVGCTQPRRVAAVTVAGRVAEEMgaVLGHE-V 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 330 SYQIRYEGNVTE-ETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIvtlRAKRNlPLKLLIMS 408
Cdd:cd17980   80 GYCIRFDDCTDPqATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKI---QKKRG-DLRLIVAS 155

                 ....*...
gi 767974935 409 ATLRVEDF 416
Cdd:cd17980  156 ATLDAEKF 163
PRK11664 PRK11664
ATP-dependent RNA helicase HrpB; Provisional
252-795 1.18e-50

ATP-dependent RNA helicase HrpB; Provisional


Pssm-ID: 236950 [Multi-domain]  Cd Length: 812  Bit Score: 192.06  E-value: 1.18e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 252 LPIlseEQVI---MEAVAEHPIVIVCGETGSGKTTQVP-QFLYEAGFSSEdsIIgVTEPRRVAAVAMSQRVAKEMN--LS 325
Cdd:PRK11664   4 LPV---AAVLpelLTALKTAPQVLLKAPTGAGKSTWLPlQLLQHGGINGK--II-MLEPRRLAARNVAQRLAEQLGekPG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 326 QRVvSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVT-LRAKrnlpLKL 404
Cdd:PRK11664  78 ETV-GYRMRAESKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDVQQgLRDD----LKL 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 405 LIMSATLrvedftQNPRLFAKPP--PVIKVESRQFPVTVHF---NKRTPLEDysgecfrKVCK-IHRML--PAGGILVFL 476
Cdd:PRK11664 153 LIMSATL------DNDRLQQLLPdaPVIVSEGRSFPVERRYqplPAHQRFDE-------AVARaTAELLrqESGSLLLFL 219
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 477 TGQAEVHALCRRLRkafppsrarpqekdddqkDSVEEmrkfkksrarakkaraevlpqinldhysvlpagegdedreaEV 556
Cdd:PRK11664 220 PGVGEIQRVQEQLA------------------SRVAS-----------------------------------------DV 240
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 557 DeeegaldsdldldlgdggqdggeqpdaslplhVLPLYSLLAPEKQAQVFKPPPEGTRLCVVATNVAETSLTIPGIKYVV 636
Cdd:PRK11664 241 L--------------------------------LCPLYGALSLAEQQKAILPAPAGRRKVVLATNIAETSLTIEGIRLVV 288
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 637 DCGKVKKRYYDRVTGVSSFRVTWVSQASADQRAGRAGRTEPGHCYRLYSSAVFGDFEQFPPPEITRRPVEDLIL------ 710
Cdd:PRK11664 289 DSGLERVARFDPKTGLTRLVTQRISQASMTQRAGRAGRLEPGICLHLYSKEQAERAAAQSEPEILHSDLSGLLLellqwg 368
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 711 -----QMKALNvekvinfpfpTPPSVeallaaeellialgALQppQKAERVKQL----QENRLscpiTALGRTMATFPVA 781
Cdd:PRK11664 369 chdpaQLSWLD----------QPPAA--------------ALA--AAKRLLQQLgaldGQGRL----TARGRKMAALGND 418
                        570
                 ....*....|....
gi 767974935 782 PRYAKMLALSRQHG 795
Cdd:PRK11664 419 PRLAAMLVAAKEDD 432
DEXHc_DHX16 cd17974
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ...
252-417 4.06e-50

DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350732 [Multi-domain]  Cd Length: 174  Bit Score: 174.23  E-value: 4.06e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEDSIIGVTEPRRVAAVAMSQRVAKEMNLS-QRVVS 330
Cdd:cd17974    1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGYTKGGGKIGCTQPRRVAAMSVAARVAEEMGVKlGNEVG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 331 YQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKrnlpLKLLIMSAT 410
Cdd:cd17974   81 YSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPD----LKLLISSAT 156

                 ....*..
gi 767974935 411 LRVEDFT 417
Cdd:cd17974  157 MDAEKFS 163
DEXHc_DHX15 cd17973
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ...
240-418 4.42e-50

DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438709 [Multi-domain]  Cd Length: 187  Bit Score: 174.53  E-value: 4.42e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 240 NRSPEMQEERLKLPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFS-SEDSIIGVTEPRRVAAVAMSQRV 318
Cdd:cd17973    1 QRYFEILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELPhQPKKLVACTQPRRVAAMSVAQRV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 319 AKEMNLS-QRVVSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAK 397
Cdd:cd17973   81 AEEMDVKlGEEVGYSIRFEDCSSAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRRRPD 160
                        170       180
                 ....*....|....*....|.
gi 767974935 398 rnlpLKLLIMSATLRVEDFTQ 418
Cdd:cd17973  161 ----LKLIVMSATLDAGKFQK 177
DEXHc_DHX8 cd17971
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ...
247-418 5.00e-49

DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350729 [Multi-domain]  Cd Length: 179  Bit Score: 171.51  E-value: 5.00e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 247 EERLKLPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEdSIIGVTEPRRVAAVAMSQRVAKEMN--L 324
Cdd:cd17971    1 EQRESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAEAGYTSR-GKIGCTQPRRVAAMSVAKRVAEEFGccL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 325 SQRVvSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVtlraKRNLPLKL 404
Cdd:cd17971   80 GQEV-GYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTV----QKRPDLKL 154
                        170
                 ....*....|....
gi 767974935 405 LIMSATLRVEDFTQ 418
Cdd:cd17971  155 IVTSATLDAVKFSQ 168
DEXHc_DHX38 cd17983
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ...
252-417 1.31e-48

DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350741 [Multi-domain]  Cd Length: 173  Bit Score: 169.95  E-value: 1.31e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSeDSIIGVTEPRRVAAVAMSQRVAKEMN--LSQRVv 329
Cdd:cd17983    1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHEDGYTD-YGMIGCTQPRRVAAMSVAKRVSEEMGveLGEEV- 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 330 SYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKrnlpLKLLIMSA 409
Cdd:cd17983   79 GYAIRFEDCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRD----LKLIVTSA 154

                 ....*...
gi 767974935 410 TLRVEDFT 417
Cdd:cd17983  155 TMDADKFA 162
DEXHc_DHX34 cd17979
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ...
252-417 1.16e-46

DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350737 [Multi-domain]  Cd Length: 170  Bit Score: 164.54  E-value: 1.16e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSedsiIGVTEPRRVAAVAMSQRVAKEmNLSQ--RVV 329
Cdd:cd17979    1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGFRH----IACTQPRRIACISLAKRVAFE-SLNQygSKV 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 330 SYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKrnlpLKLLIMSA 409
Cdd:cd17979   76 AYQIRFERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPD----LKLILMSA 151

                 ....*...
gi 767974935 410 TLRVEDFT 417
Cdd:cd17979  152 TINIELFS 159
DEXHc_HrpA cd17989
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ...
252-432 1.02e-45

DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350747 [Multi-domain]  Cd Length: 173  Bit Score: 161.85  E-value: 1.02e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEdSIIGVTEPRRVAAVAMSQRVAKEMNLS-QRVVS 330
Cdd:cd17989    1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLELGRGIR-GLIGHTQPRRLAARSVAERIAEELKTElGGAVG 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 331 YQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVtlraKRNLPLKLLIMSAT 410
Cdd:cd17989   80 YKVRFTDQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLL----PRRPDLKVIITSAT 155
                        170       180
                 ....*....|....*....|..
gi 767974935 411 LRVEDFTQNprlFAKpPPVIKV 432
Cdd:cd17989  156 IDAERFSRH---FNN-APIIEV 173
DEXHc_DHX29 cd17975
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ...
252-417 1.20e-37

DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350733 [Multi-domain]  Cd Length: 183  Bit Score: 139.28  E-value: 1.20e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYE----AGFSSEDSIIGVTEPRRVAAVAMSQRVAKEMNLS-- 325
Cdd:cd17975    1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEdlllNGGTAQKCNIVCTQPRRISAMSLATRVCEELGCEsg 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 326 ----QRVVSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKrnlp 401
Cdd:cd17975   81 pggkNSLCGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSD---- 156
                        170
                 ....*....|....*.
gi 767974935 402 LKLLIMSATLRVEDFT 417
Cdd:cd17975  157 LHLILMSATVDCEKFS 172
DEXHc_DHX36 cd17981
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ...
252-418 2.31e-36

DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350739 [Multi-domain]  Cd Length: 180  Bit Score: 135.36  E-value: 2.31e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLY----EAGFSSEDSIIgVTEPRRVAAVAMSQRVAKEMNLSQ- 326
Cdd:cd17981    1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILddaiERGKGSSCRIV-CTQPRRISAISVAERVAAERAESCg 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 327 --RVVSYQIRYEGNVT-EETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRakrnLPLK 403
Cdd:cd17981   80 lgNSTGYQIRLESRKPrKQGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFR----SDLK 155
                        170
                 ....*....|....*
gi 767974935 404 LLIMSATLRVEDFTQ 418
Cdd:cd17981  156 VILMSATLNAEKFSD 170
DEXHc_DHX57 cd17985
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ...
252-418 2.80e-33

DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350743 [Multi-domain]  Cd Length: 177  Bit Score: 126.49  E-value: 2.80e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFS---SEDSIIGVTEPRRVAAVAMSQRVAKEMnlSQRV 328
Cdd:cd17985    1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLQgppLPVANIICTQPRRISAISVAERVAQER--AERV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 329 ---VSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKrnlpLKLL 405
Cdd:cd17985   79 gqsVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPD----LKVI 154
                        170
                 ....*....|...
gi 767974935 406 IMSATLRVEDFTQ 418
Cdd:cd17985  155 LMSATLNAELFSD 167
DEXHc_TDRD9 cd17988
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ...
252-432 3.30e-33

DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350746 [Multi-domain]  Cd Length: 180  Bit Score: 126.46  E-value: 3.30e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQF-LYEAGFSSEDSIIGVTEPRRVAAVAMSQRVAKEMNLSQ-RVV 329
Cdd:cd17988    1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFiLDHYYKRGKYCNIVVTQPRRIAAISIARRVSQEREWTLgSLV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 330 SYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKRnlpLKLLIMSA 409
Cdd:cd17988   81 GYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLRTNSRH---VKIILMSA 157
                        170       180
                 ....*....|....*....|...
gi 767974935 410 TLRVEDFTQNPRLFAKPPPVIKV 432
Cdd:cd17988  158 TISCKEFADYFTTPNNPAYVFEV 180
DEXHc_DHX30 cd17976
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ...
252-432 4.24e-32

DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350734 [Multi-domain]  Cd Length: 178  Bit Score: 122.98  E-value: 4.24e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSS---EDSIIGVTEPRRVAAVAMSQRVAKEMNLS-QR 327
Cdd:cd17976    1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYVLRgrgARCNVVITQPRRISAVSVAQRVAHELGPNlRR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 328 VVSYQIRYEGNVTEE-TRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKrnlpLKLLI 406
Cdd:cd17976   81 NVGYQVRLESRPPPRgGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPE----LRVVL 156
                        170       180
                 ....*....|....*....|....*.
gi 767974935 407 MSATLRVEDFTQnprlFAKPPPVIKV 432
Cdd:cd17976  157 MSATGDNQRLSR----YFGGCPVVRV 178
DEXHc_YTHDC2 cd17987
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ...
252-432 1.41e-30

DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350745 [Multi-domain]  Cd Length: 176  Bit Score: 118.78  E-value: 1.41e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEDSI-IGVTEPRRVAAVAMSQRVAKEM--NLSQrV 328
Cdd:cd17987    1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDDCYANGIPCrIFCTQPRRLAAIAVAERVAAERgeKIGQ-T 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 329 VSYQIRYEGNVTEETRIKFMTDGVLLKEIQ-KDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVtlraKRNLPLKLLIM 407
Cdd:cd17987   80 VGYQIRLESRVSPKTLLTFCTNGVLLRTLMaGDSALSTVTHVIVDEVHERDRFSDFLLTKLRDIL----QKHPNLKLILS 155
                        170       180
                 ....*....|....*....|....*
gi 767974935 408 SATLRVEDFTqnpRLFAKpPPVIKV 432
Cdd:cd17987  156 SAALDVNLFI---RYFGS-CPVIYI 176
DEXHc_HrpB cd17990
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ...
252-414 1.12e-28

DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438711 [Multi-domain]  Cd Length: 174  Bit Score: 113.20  E-value: 1.12e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVP-QFLYEAGFssEDSIIGVTEPRRVAAVAMSQRVAKEMNlsQRV-- 328
Cdd:cd17990    1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPlALLAELWI--AGGKIIVLEPRRVAARAAARRLATLLG--EAPge 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 329 -VSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRivtLRAKRNLPLKLLIM 407
Cdd:cd17990   77 tVGYRVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLE---VQQLLRDDLRLLAM 153

                 ....*..
gi 767974935 408 SATLRVE 414
Cdd:cd17990  154 SATLDGD 160
DEXHc_DHX32 cd17977
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ...
252-409 1.63e-27

DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350735 [Multi-domain]  Cd Length: 176  Bit Score: 109.92  E-value: 1.63e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSS--EDSIIGVTEPRRVAAVAMSQRVAKEMNLS-QRV 328
Cdd:cd17977    1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAEYCLSAhyQHGVVVCTQVHKQTAVWLALRVADEMDVNiGHE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 329 VSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKrnlpLKLLIMS 408
Cdd:cd17977   81 VGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPE----LKLVIIT 156

                 .
gi 767974935 409 A 409
Cdd:cd17977  157 C 157
DEXHc_DHX9 cd17972
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ...
247-432 9.13e-27

DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350730 [Multi-domain]  Cd Length: 234  Bit Score: 109.54  E-value: 9.13e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 247 EERLKLPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSE---DSIIGVTEPRRVAAVAMSQRVAKEMN 323
Cdd:cd17972   54 QERELLPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYILDDFIQNDraaECNIVVTQPRRISAVSVAERVAFERG 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 324 LS-QRVVSYQIRYEGNVTE-ETRIKFMTDGVLLKEIQKDFLLLRYkvVIIDEAHERSVYTDILIGLLSRIVtlRAKRNlp 401
Cdd:cd17972  134 EEvGKSCGYSVRFESVLPRpHASILFCTVGVLLRKLEAGIRGISH--VIVDEIHERDINTDFLLVVLRDVV--QAYPD-- 207
                        170       180       190
                 ....*....|....*....|....*....|.
gi 767974935 402 LKLLIMSATLRVEDFTQnprlFAKPPPVIKV 432
Cdd:cd17972  208 LRVILMSATIDTSMFCE----YFFNCPVIEV 234
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
768-858 4.73e-26

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 103.09  E-value: 4.73e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935  768 ITALGRTMATFPVAPRYAKMLALSRQHGCLPYAITIVASMTVRELFEELDRPAASDEELTRLKSKRARVAQMKRTWAGQG 847
Cdd:pfam04408  17 LTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFLDPRSAAKAARRRRRAADEKARAKFARLD 96
                          90
                  ....*....|.
gi 767974935  848 aslKLGDLMVL 858
Cdd:pfam04408  97 ---LEGDHLTL 104
DEXQc_DQX1 cd17986
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ...
252-432 1.28e-24

DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350744 [Multi-domain]  Cd Length: 177  Bit Score: 101.51  E-value: 1.28e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 252 LPILSEEQVIMEAV-AEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEDS--IIGVTEPRRVAAVAMSQRVAKEMNLS-QR 327
Cdd:cd17986    1 LPIWAAKFTFLEQLeSPSGIVLVSGEPGSGKSTQVPQWCAEFALSRGFQkgQVTVTQPHPLAARSLALRVADEMDLNlGH 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 328 VVSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKrnlpLKLLIm 407
Cdd:cd17986   81 EVGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPE----LRVVV- 155
                        170       180
                 ....*....|....*....|....*..
gi 767974935 408 satlrVEDFTQNPRL--FAKPPPVIKV 432
Cdd:cd17986  156 -----VTSPALEPKLraFWGNPPVVHV 177
DEXDc smart00487
DEAD-like helicases superfamily;
258-418 4.19e-24

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 101.03  E-value: 4.19e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935   258 EQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEDSIIGVTEPRRVAAVAMSQRVAKEMNLSQRVV-------S 330
Cdd:smart00487  14 KEAIEALLSGLRDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVvglyggdS 93
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935   331 YQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLL-RYKVVIIDEAHERS--VYTDILIGLLSRIvtlrakrNLPLKLLIM 407
Cdd:smart00487  94 KREQLRKLESGKTDILVTTPGRLLDLLENDKLSLsNVDLVILDEAHRLLdgGFGDQLEKLLKLL-------PKNVQLLLL 166
                          170
                   ....*....|...
gi 767974935   408 SATL--RVEDFTQ 418
Cdd:smart00487 167 SATPpeEIENLLE 179
HA2 smart00847
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ...
768-859 1.03e-15

Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 214852 [Multi-domain]  Cd Length: 82  Bit Score: 72.69  E-value: 1.03e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935   768 ITALGRTMATFPVAPRYAKMLALSRQHGCLPYAITIVASMTVRELFEeldrpaasdeeltrlKSKRARVAQMKRTWAGQG 847
Cdd:smart00847  11 LTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPRP---------------KEKREDADAARRRFADPE 75
                           90
                   ....*....|..
gi 767974935   848 aslklGDLMVLL 859
Cdd:smart00847  76 -----SDHLTLL 82
HELICc smart00490
helicase superfamily c-terminal domain;
585-674 1.76e-11

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 60.69  E-value: 1.76e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935   585 SLPLHVLPLYSLLAPEKQAQVFKPPPEGTRLCVVATNVAETSLTIPGIKYVVDCGkvkkryydrvtgvssfrvTWVSQAS 664
Cdd:smart00490   9 ELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYD------------------LPWSPAS 70
                           90
                   ....*....|
gi 767974935   665 ADQRAGRAGR 674
Cdd:smart00490  71 YIQRIGRAGR 80
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
588-674 4.17e-09

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 54.91  E-value: 4.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935  588 LHVLPLYSLLAPEKQAQVFKPPPEGTRLCVVATNVAETSLTIPGIKYVVDcgkvkkryYDRVTGVSSFRvtwvsqasadQ 667
Cdd:pfam00271  39 IKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPDVDLVIN--------YDLPWNPASYI----------Q 100

                  ....*..
gi 767974935  668 RAGRAGR 674
Cdd:pfam00271 101 RIGRAGR 107
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
271-411 1.29e-08

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 54.94  E-value: 1.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935  271 VIVCGETGSGKTT--QVPqFLYEAGFSSEDSIIGVTEPRRVAAVAMSQRVAKEMNLSQRVVSY-----QIRYEGNVTEET 343
Cdd:pfam00270  17 VLVQAPTGSGKTLafLLP-ALEALDKLDNGPQALVLAPTRELAEQIYEELKKLGKGLGLKVASllggdSRKEQLEKLKGP 95
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935  344 RIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSV--YTDILIGLLSRivtLRAKRnlplKLLIMSATL 411
Cdd:pfam00270  96 DILVGTPGRLLDLLQERKLLKNLKLLVLDEAHRLLDmgFGPDLEEILRR---LPKKR----QILLLSATL 158
PHA02653 PHA02653
RNA helicase NPH-II; Provisional
258-420 2.10e-08

RNA helicase NPH-II; Provisional


Pssm-ID: 177443 [Multi-domain]  Cd Length: 675  Bit Score: 58.07  E-value: 2.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 258 EQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYE-----AGFSSEDSIIGVTEPR-------RVAAV-AMSQRVAKEMNL 324
Cdd:PHA02653 169 QLKIFEAWISRKPVVLTGGTGVGKTSQVPKLLLWfnylfGGFDNLDKIDPNFIERpivlslpRVALVrLHSITLLKSLGF 248
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 325 SQRVVS-YQIRYeGNVTEETR-IKFMTDGVLLK----EIQKdflLLRYKVVIIDEAHERSVYTDILIGLlsrivtLRAKR 398
Cdd:PHA02653 249 DEIDGSpISLKY-GSIPDELInTNPKPYGLVFSthklTLNK---LFDYGTVIIDEVHEHDQIGDIIIAV------ARKHI 318
                        170       180
                 ....*....|....*....|....*..
gi 767974935 399 NLPLKLLIMSATL-----RVEDFTQNP 420
Cdd:PHA02653 319 DKIRSLFLMTATLeddrdRIKEFFPNP 345
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
271-410 4.00e-08

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 53.18  E-value: 4.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 271 VIVCGETGSGKTTQVPQFLYEAGFSSEDSIIgVTEPRRVAAVAMSQRVAKEMNLSQRVVSYQIRY-----EGNVTEETRI 345
Cdd:cd00046    4 VLITAPTGSGKTLAALLAALLLLLKKGKKVL-VLVPTKALALQTAERLRELFGPGIRVAVLVGGSsaeerEKNKLGDADI 82
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767974935 346 KFMTDGVLLKEIQKD--FLLLRYKVVIIDEAHERSVYTDiliGLLSRIVTLRAKRNLPLKLLIMSAT 410
Cdd:cd00046   83 IIATPDMLLNLLLREdrLFLKDLKLIIVDEAHALLIDSR---GALILDLAVRKAGLKNAQVILLSAT 146
DEXHc_Ski2 cd17921
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ...
259-425 1.53e-05

DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350679 [Multi-domain]  Cd Length: 181  Bit Score: 46.49  E-value: 1.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 259 QVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEDSIIgVTEPRRvaavAMSQRVAKEMN-LSQRVVSYQIRYEG 337
Cdd:cd17921    8 EALRALYLSGDSVLVSAPTSSGKTLIAELAILRALATSGGKAV-YIAPTR----ALVNQKEADLReRFGPLGKNVGLLTG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 338 NVTE------ETRIKFMT----DGVLLKEIQKDFLLLRYkvVIIDEAH-----ERSVytdILIGLLSRIvtLRAKRNlpL 402
Cdd:cd17921   83 DPSVnklllaEADILVATpeklDLLLRNGGERLIQDVRL--VVVDEAHligdgERGV---VLELLLSRL--LRINKN--A 153
                        170       180
                 ....*....|....*....|...
gi 767974935 403 KLLIMSATLrvedftQNPRLFAK 425
Cdd:cd17921  154 RFVGLSATL------PNAEDLAE 170
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
617-677 3.56e-04

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 39.99  E-value: 3.56e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767974935 617 VVATNVAETSLTIPGIKYVVDCGKVKkryydrvtgvssfrvtwvSQASADQRAGRAGRTEP 677
Cdd:cd18785   26 LVATNVLGEGIDVPSLDTVIFFDPPS------------------SAASYIQRVGRAGRGGK 68
DEXHc_viral_Ns3 cd17931
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional ...
277-410 5.08e-04

DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional protein found in pestiviruses that contains an N-terminal protease and a C-terminal helicase. The N-terminal domain is a chymotrypsin-like serine protease, which is responsible for most of the maturation cleavages of the polyprotein precursor in the cytosolic side of the endoplasmic reticulum membrane. The C-terminal domain, about two-thirds of NS3, is a helicase belonging to superfamily 2 (SF2) thought to be important for unwinding highly structured regions of the RNA genome during replication. NS3 plays an essential role in viral polyprotein processing and genome replication. NS3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350689 [Multi-domain]  Cd Length: 151  Bit Score: 41.38  E-value: 5.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 277 TGSGKTTQVPQFLYEAGFSSEDSIIgVTEPRRVAAVAMSQRvakemnLSQRVVSYQIryeGNVTEETR----IKFMTDGV 352
Cdd:cd17931   10 PGAGKTTRVLPQIIREAIKKRLRTL-VLAPTRVVAAEMYEA------LRGLPIRYRT---GAVKEEHGgneiVDYMCHGT 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767974935 353 LLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKRnlplkLLIMSAT 410
Cdd:cd17931   80 FTCRLLSPKRVPNYNLIIMDEAHFTDPASIAARGYIHTRVEMGEAA-----VIFMTAT 132
Cas3_I cd09639
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ...
270-438 1.21e-03

CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I


Pssm-ID: 187770 [Multi-domain]  Cd Length: 353  Bit Score: 42.03  E-value: 1.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 270 IVIVCGETGSGKTTQVPQF-LYEAGFSSEDSIIgVTEPRRVAAVAMSQRvAKEMnLSQRVVSYQI----RYEGNVTEE-- 342
Cdd:cd09639    1 LLVIEAPTGYGKTEAALLWaLHSLKSQKADRVI-IALPTRATINAMYRR-AKEA-FGETGLYHSSilssRIKEMGDSEef 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935 343 ----------------TRIKFMTDGVLLKEIQKDF-------LLLRYKVVIIDEAHERSVYTDILIgllsrIVTLRAKRN 399
Cdd:cd09639   78 ehlfplyihsndtlflDPITVCTIDQVLKSVFGEFghyeftlASIANSLLIFDEVHFYDEYTLALI-----LAVLEVLKD 152
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 767974935 400 LPLKLLIMSATL--RVEDFTQN--PRLFAKPPPVIKVESRQFP 438
Cdd:cd09639  153 NDVPILLMSATLpkFLKEYAEKigYVEENEPLDLKPNERAPFI 195
AAA_22 pfam13401
AAA domain;
270-375 2.41e-03

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 38.86  E-value: 2.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935  270 IVIVCGETGSGKTTQVPQFLYEAGfSSEDSIIGVTEPRRVAAVAMSQRVAKEmnlsqrvvsYQIRYEGNVTEETRIKFMT 349
Cdd:pfam13401   7 ILVLTGESGTGKTTLLRRLLEQLP-EVRDSVVFVDLPSGTSPKDLLRALLRA---------LGLPLSGRLSKEELLAALQ 76
                          90       100
                  ....*....|....*....|....*.
gi 767974935  350 DgvLLKEIQkdflllRYKVVIIDEAH 375
Cdd:pfam13401  77 Q--LLLALA------VAVVLIIDEAQ 94
cas3_core TIGR01587
CRISPR-associated helicase Cas3; This model represents the highly conserved core region of an ...
270-522 2.90e-03

CRISPR-associated helicase Cas3; This model represents the highly conserved core region of an alignment of Cas3, a protein found in association with CRISPR repeat elements in a broad range of bacteria and archaea. Cas3 appears to be a helicase, with regions found by pfam00270 (DEAD/DEAH box helicase) and pfam00271 (Helicase conserved C-terminal domain). Some but not all members have an N-terminal HD domain region (pfam01966) that is not included within this model.


Pssm-ID: 273707 [Multi-domain]  Cd Length: 359  Bit Score: 40.90  E-value: 2.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935  270 IVIVCGETGSGKTTQVPQF-LYEAGFSSEDSIIgVTEPRRVAAVAMSQRvAKEMNLSQRVV----SYQIRYEGNVTEE-- 342
Cdd:TIGR01587   1 LLVIEAPTGYGKTEAALLWaLHSIKSQKADRVI-IALPTRATINAMYRR-AKELFGSELVGlhhsSSFSRIKEMGDSEef 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935  343 ----------------TRIKFMTDGVLLKEIQKDF-------LLLRYKVVIIDEAHERSVYTDILIgllsrIVTLRAKRN 399
Cdd:TIGR01587  79 ehlfplyihsndklflDPITVCTIDQVLKSVFGEFghyeftlASIANSLLIFDEVHFYDEYTLALI-----LAVLEVLKD 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935  400 LPLKLLIMSATL--RVEDFTQN--PRLFAKPPPVIkvesrqfPVTVHFNKRTPL-EDYSGECFRKVCKIHRMLPAGG-IL 473
Cdd:TIGR01587 154 NDVPILLMSATLpkFLKEYAEKigYVEFNEPLDLK-------EERRFENHRFILiESDKVGEISSLERLLEFIKKGGsIA 226
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767974935  474 VFLTGQAEVHALCRRLRKAFPPSR-----ARPQEKDDDQKDsVEEMRKFKKSRA 522
Cdd:TIGR01587 227 IIVNTVDRAQEFYQQLKEKAPEEEiilyhSRFTEKDRAKKE-AELLREMKKSNE 279
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
268-416 3.26e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 38.89  E-value: 3.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974935   268 HPIVIVCGETGSGKTTQVPQFLYEAGFSSEDSIIGVTEPRRvaavamsqrvakEMNLSQRVVSYQIRYEGNVTEETRIKf 347
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDIL------------EEVLDQLLLIIVGGKKASGSGELRLR- 68
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767974935   348 mtdgVLLKEIQKdfllLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKRNLPLKLLIMSATLRVEDF 416
Cdd:smart00382  69 ----LALALARK----LKPDVLILDEITSLLDAEQEALLLLLEELRLLLLLKSEKNLTVILTTNDEKDL 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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