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Conserved domains on  [gi|767961981|ref|XP_011537746|]
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phospholipid phosphatase 4 isoform X1 [Homo sapiens]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 10130247)

type 2 phosphatidic acid phosphatase (PAP2) family protein similar to mammalian phospholipid phosphatases that catalyzes the conversion of phosphatidic acid to diacylglycerol

EC:  3.1.3.-
Gene Ontology:  GO:0006644|GO:0008195|GO:0046839
PubMed:  12447906

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 35-223 5.96e-94

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


:

Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 274.87  E-value: 5.96e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961981  35 WLYKNPLVQSDNIPTRLMFAISFLTPLAVICVVKIIRRTDKTEIKEAFLAVSLALALNGVCTNTIKLIVGRPRPDFFYRC 114
Cdd:cd03390    1 PSISYPFAESETVPTWLLVIISVGIPLLVIILISLFFRRSLWDLHTSLLGLLLSVSLNGVITNVLKNYAGRPRPDFLARC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961981 115 FPDGVMNSEMH------CTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLAGKLHCFteSGRGKSWRLCAAILPLYCAM 188
Cdd:cd03390   81 FPDGGTPSDTLvgidicCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIF--DPRGSSWRLLLALLPLLLAI 158

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 767961981 189 MIALSRMCDYKHHWQDSFVGGVIGLIFAYICYRQH 223
Cdd:cd03390  159 LVAVSRTRDYRHHFSDVIAGSLIGLIIAYLSYRQY 193
 
Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 35-223 5.96e-94

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 274.87  E-value: 5.96e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961981  35 WLYKNPLVQSDNIPTRLMFAISFLTPLAVICVVKIIRRTDKTEIKEAFLAVSLALALNGVCTNTIKLIVGRPRPDFFYRC 114
Cdd:cd03390    1 PSISYPFAESETVPTWLLVIISVGIPLLVIILISLFFRRSLWDLHTSLLGLLLSVSLNGVITNVLKNYAGRPRPDFLARC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961981 115 FPDGVMNSEMH------CTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLAGKLHCFteSGRGKSWRLCAAILPLYCAM 188
Cdd:cd03390   81 FPDGGTPSDTLvgidicCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIF--DPRGSSWRLLLALLPLLLAI 158

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 767961981 189 MIALSRMCDYKHHWQDSFVGGVIGLIFAYICYRQH 223
Cdd:cd03390  159 LVAVSRTRDYRHHFSDVIAGSLIGLIIAYLSYRQY 193
PLN02250 PLN02250
lipid phosphate phosphatase
 22-226 2.76e-61

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 195.92  E-value: 2.76e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961981  22 LDPFQRVIQPEEIWLYKNPLvQSDNIPTRLMFAISFLTPLAVICVVKIIRRtDKTEIKEAFLAVSLALALNGVCTNTIKL 101
Cdd:PLN02250  42 IEPFHRFVGKDMLTDLSYPL-QDNTIPFWAVPLIAILLPFAVILVYYFIRR-DVYDLHHAILGLLFSVLITGVITDAIKD 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961981 102 IVGRPRPDFFYRCFPDGV-----MNSEMHCTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLAGKLHCFTEsgRGKSWR 176
Cdd:PLN02250 120 AVGRPRPDFFWRCFPDGKgvfhpVTTDVLCTGAKSVIKEGHKSFPSGHTSWSFAGLGFLSLYLSGKIRVFDR--RGHVAK 197

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 767961981 177 LCAAILPLYCAMMIALSRMCDYKHHWQDSFVGGVIGLIFAYICYRQHYPP 226
Cdd:PLN02250 198 LCIVFLPLLVAALVGVSRVDDYWHHWQDVFAGALIGLTVASFCYLQFFPP 247
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 84-224 2.27e-23

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 91.71  E-value: 2.27e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961981   84 AVSLALALNGVCTNTIKLIVGRPRPDFFYRCFPDgvmnsemhcTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLAGkl 163
Cdd:pfam01569   1 ILLLALALAGLLSSVLKDYFGRPRPFFLLLEGGL---------VPAPSTLPGLGYSFPSGHSATAFALALLLALLLRR-- 69

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767961981  164 hcftesgRGKSWRLCAAILPLYCAMMIALSRMCDYKHHWQDSFVGGVIGLIFAYICYRQHY 224
Cdd:pfam01569  70 -------LRKIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVP 123
acidPPc smart00014
Acid phosphatase homologues;
81-220 6.71e-18

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 77.00  E-value: 6.71e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961981    81 AFLAVSLALAlngvcTNTIKLIVGRPRPDFFYRCFPdgvmnsemHCTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLa 160
Cdd:smart00014   1 ALLAVVSQLF-----NGVIKNYFGRPRPFFLSIGDA--------CCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLYL- 66

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961981   161 gklhcfteSGRGKSWRLCAAILPLycAMMIALSRMCDYKHHWQDSFVGGVIGLIFAYICY 220
Cdd:smart00014  67 --------PARAGRKLLIFLLLLL--ALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 18-221 2.10e-11

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 61.21  E-value: 2.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961981  18 FTEFLDPFQRVIQPEEIWLYKNPLVQSDNIPTRLMFAISFLTPLAVICVVKIIRRTDKTEIKEAFLAVSLALALNGVCTN 97
Cdd:COG0671   11 LLLLLLADLLALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALLLLLLLLLLL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961981  98 TIKLIVGRPRPDffyrcfpdgvmnseMHCTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLAGKLhcftesgrgksWRL 177
Cdd:COG0671   91 LLKYLFGRPRPF--------------VVPDLELLLGTAGGYSFPSGHAAAAFALALVLALLLPRRW-----------LAA 145

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 767961981 178 CAAILplycAMMIALSRMCDYKHHWQDSFVGGVIGLIFAYICYR 221
Cdd:COG0671  146 LLLAL----ALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLA 185
 
Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 35-223 5.96e-94

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 274.87  E-value: 5.96e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961981  35 WLYKNPLVQSDNIPTRLMFAISFLTPLAVICVVKIIRRTDKTEIKEAFLAVSLALALNGVCTNTIKLIVGRPRPDFFYRC 114
Cdd:cd03390    1 PSISYPFAESETVPTWLLVIISVGIPLLVIILISLFFRRSLWDLHTSLLGLLLSVSLNGVITNVLKNYAGRPRPDFLARC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961981 115 FPDGVMNSEMH------CTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLAGKLHCFteSGRGKSWRLCAAILPLYCAM 188
Cdd:cd03390   81 FPDGGTPSDTLvgidicCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIF--DPRGSSWRLLLALLPLLLAI 158

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 767961981 189 MIALSRMCDYKHHWQDSFVGGVIGLIFAYICYRQH 223
Cdd:cd03390  159 LVAVSRTRDYRHHFSDVIAGSLIGLIIAYLSYRQY 193
PLN02250 PLN02250
lipid phosphate phosphatase
 22-226 2.76e-61

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 195.92  E-value: 2.76e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961981  22 LDPFQRVIQPEEIWLYKNPLvQSDNIPTRLMFAISFLTPLAVICVVKIIRRtDKTEIKEAFLAVSLALALNGVCTNTIKL 101
Cdd:PLN02250  42 IEPFHRFVGKDMLTDLSYPL-QDNTIPFWAVPLIAILLPFAVILVYYFIRR-DVYDLHHAILGLLFSVLITGVITDAIKD 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961981 102 IVGRPRPDFFYRCFPDGV-----MNSEMHCTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLAGKLHCFTEsgRGKSWR 176
Cdd:PLN02250 120 AVGRPRPDFFWRCFPDGKgvfhpVTTDVLCTGAKSVIKEGHKSFPSGHTSWSFAGLGFLSLYLSGKIRVFDR--RGHVAK 197

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 767961981 177 LCAAILPLYCAMMIALSRMCDYKHHWQDSFVGGVIGLIFAYICYRQHYPP 226
Cdd:PLN02250 198 LCIVFLPLLVAALVGVSRVDDYWHHWQDVFAGALIGLTVASFCYLQFFPP 247
PLN02731 PLN02731
Putative lipid phosphate phosphatase
 22-241 4.43e-50

Putative lipid phosphate phosphatase


Pssm-ID: 178332  Cd Length: 333  Bit Score: 167.51  E-value: 4.43e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961981  22 LDPFQRVIQPEEIWLYKNPLvQSDNIPTRLMFAISFLTPLaVICVVKIIRRTDKTEIKEAFLAVSLALALNGVCTNTIKL 101
Cdd:PLN02731  61 IHPFYRFVGKDMMTDLSYPL-KSNTVPIWSVPVYAMLLPL-VIFIFIYFRRRDVYDLHHAVLGLLYSVLVTAVLTDAIKN 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961981 102 IVGRPRPDFFYRCFPDG--VMNS--EMHCTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLAGKLHCFteSGRGKSWRL 177
Cdd:PLN02731 139 AVGRPRPDFFWRCFPDGkaLYDSlgDVICHGDKSVIREGHKSFPSGHTSWSFSGLGFLSLYLSGKIQAF--DGKGHVAKL 216

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767961981 178 CAAILPLYCAMMIALSRMCDYKHHWQDSFVGGVIGLIFAYICYRQHYPPLANTACHKPYVSLRV 241
Cdd:PLN02731 217 CIVILPLLFAALVGISRVDDYWHHWQDVFAGGLLGLAISTICYLQFFPPPYHTEGWGPYAYFQV 280
PLN02715 PLN02715
lipid phosphate phosphatase
 21-240 3.03e-43

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 149.82  E-value: 3.03e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961981  21 FLDPFQRVIQPEEIWLYKNPLvQSDNIPTRLMFAISFLTPLaVICVVKIIRRTDKTEIKEAFLAVSLALALNGVCTNTIK 100
Cdd:PLN02715  66 LISPFYRYVGKDMMTDLKYPF-KDNTVPIWSVPVYAVLLPI-ILFVCFYLKRRCVYDLHHSILGLLFAVLITGVITDSIK 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961981 101 LIVGRPRPDFFYRCFPDGvmnSEMH-------CTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLAGKLHCFTESGRGK 173
Cdd:PLN02715 144 VATGRPRPNFYWRCFPDG---KELYdalggviCHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLSGKIKAFNGEGHVA 220

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767961981 174 swRLCAAILPLYCAMMIALSRMCDYKHHWQDSFVGGVIGLIFAYICYRQHYPPLANTACHKPYVSLR 240
Cdd:PLN02715 221 --KLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGILVAAFCYRQFYPNPYHEEGWGPYAYFK 285
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 81-220 1.75e-26

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 99.84  E-value: 1.75e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961981  81 AFLAVSLALALNGVCTNTIKLIVGRPRPDFFYRCFPDGvmnsemhctgDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLA 160
Cdd:cd01610    4 LALLLLLALLAGLLLTGVLKYLFGRPRPYFLLRCGPDG----------DPLLLTEGGYSFPSGHAAFAFALALFLALLLP 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961981 161 GKLhcftesgrgksWRLCAAILPLYCAMMIALSRMCDYKHHWQDSFVGGVIGLIFAYICY 220
Cdd:cd01610   74 RRL-----------LRLLLGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLVL 122
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 82-218 4.90e-26

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 99.63  E-value: 4.90e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961981  82 FLAVSLA-LALNGVCTNTIKLIVGRPRPDFFYRCFPDG----------VMNSEMHCTGDPDLVSEGRKSFPSIHSSFAFS 150
Cdd:cd03384    5 FVGVFLFgLFATQLLTDLGKYVTGRLRPHFLDVCKPNYtdltcsldhqYIADCTCCTGDPDLIREARLSFPSGHASLSMY 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767961981 151 GLGFTTFYLAGKLhcftesgrgkSWRLCAAILPL--YCAMMIA----LSRMCDYKHHWQDSFVGGVIGLIFAYI 218
Cdd:cd03384   85 AAVFLALYLQARL----------KLRGSRLLRPLlqFLLLALAlyvgLSRISDYKHHWSDVLAGALLGSVIALF 148
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 84-224 2.27e-23

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 91.71  E-value: 2.27e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961981   84 AVSLALALNGVCTNTIKLIVGRPRPDFFYRCFPDgvmnsemhcTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLAGkl 163
Cdd:pfam01569   1 ILLLALALAGLLSSVLKDYFGRPRPFFLLLEGGL---------VPAPSTLPGLGYSFPSGHSATAFALALLLALLLRR-- 69

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767961981  164 hcftesgRGKSWRLCAAILPLYCAMMIALSRMCDYKHHWQDSFVGGVIGLIFAYICYRQHY 224
Cdd:pfam01569  70 -------LRKIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVP 123
acidPPc smart00014
Acid phosphatase homologues;
81-220 6.71e-18

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 77.00  E-value: 6.71e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961981    81 AFLAVSLALAlngvcTNTIKLIVGRPRPDFFYRCFPdgvmnsemHCTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLa 160
Cdd:smart00014   1 ALLAVVSQLF-----NGVIKNYFGRPRPFFLSIGDA--------CCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLYL- 66

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961981   161 gklhcfteSGRGKSWRLCAAILPLycAMMIALSRMCDYKHHWQDSFVGGVIGLIFAYICY 220
Cdd:smart00014  67 --------PARAGRKLLIFLLLLL--ALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 79-220 7.33e-12

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 60.42  E-value: 7.33e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961981  79 KEAFLAVSLALALNGVCTNTIKLIVGRPRPDffyrcfpdgvmnsemhctGDPDlvseGRKSFPSIHSSFAFSGLGFTTFy 158
Cdd:cd03394    2 REGLLILAEAAALTAAVTEGLKFAVGRARPD------------------GSNN----GYRSFPSGHTASAFAAATFLQY- 58

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767961981 159 lagklhcftESGRGKSWrlcaaiLPLYC-AMMIALSRMCDYKHHWQDSFVGGVIGLIFAYICY 220
Cdd:cd03394   59 ---------RYGWRWYG------IPAYAlASLVGASRVVANRHWLSDVLAGAAIGILVGYLVT 106
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 18-221 2.10e-11

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 61.21  E-value: 2.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961981  18 FTEFLDPFQRVIQPEEIWLYKNPLVQSDNIPTRLMFAISFLTPLAVICVVKIIRRTDKTEIKEAFLAVSLALALNGVCTN 97
Cdd:COG0671   11 LLLLLLADLLALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALLLLLLLLLLL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961981  98 TIKLIVGRPRPDffyrcfpdgvmnseMHCTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLAGKLhcftesgrgksWRL 177
Cdd:COG0671   91 LLKYLFGRPRPF--------------VVPDLELLLGTAGGYSFPSGHAAAAFALALVLALLLPRRW-----------LAA 145

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 767961981 178 CAAILplycAMMIALSRMCDYKHHWQDSFVGGVIGLIFAYICYR 221
Cdd:COG0671  146 LLLAL----ALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLA 185
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 49-220 3.40e-10

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 57.62  E-value: 3.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961981  49 TRLMFAISFL------TPL-AVICVVKIIRRTdkteiKEAFLAVSLALALNGVCTNTIKLIVGRPRPDFFYRCFPDGvmn 121
Cdd:cd03392   29 TAFMTAITFLgspavlLIIvLLLALLLLLKRR-----RRAALFLLLALLGGGALNTLLKLLVQRPRPPLHLLVPEGG--- 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961981 122 semhctgdpdlvsegrKSFPSIHSSFAFSGLGFTTFYLAGKLHcftesgrGKSWRLCAAILPLYCAMMIALSRMcdYKH- 200
Cdd:cd03392  101 ----------------YSFPSGHAMGATVLYGFLAYLLARRLP-------RRRVRILLLILAAILILLVGLSRL--YLGv 155

                        170       180
                 ....*....|....*....|.
gi 767961981 201 HWQDSFVGGV-IGLIFAYICY 220
Cdd:cd03392  156 HYPSDVLAGWlLGLAWLALLI 176
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 87-221 1.93e-07

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 50.01  E-value: 1.93e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961981  87 LALALNGVCTNTIKLIVGRPRPDFFyrcFPDGvMNSEMHCTGDPDLvsegrKSFPSIHSSFAFSgLGFTTFYLAGKlhcf 166
Cdd:cd03389   76 ATVALSGILVNLLKFIIGRARPKLL---FDDG-LYGFDPFHADYAF-----TSFPSGHSATAGA-AAAALALLFPR---- 141

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767961981 167 tesgrgksWRLcaaiLPLYCAMMIALSRMCDYKHHWQDSFVGGVIGLIFAYICYR 221
Cdd:cd03389  142 --------YRW----AFILLALLIAFSRVIVGAHYPSDVIAGSLLGAVTALALYQ 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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