fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963296  887 ANVLEIISPNLFYALPKGMPENQEKLCMLTAELLEYCNAPKSRPPYRPRIGDACCAKYTSDDFWYRAVVLGTSDTDVEVL 966
Cdd:cd20411     1 ALVLEVISPDLFYALPKTGQVNVEKLKALMTELAEYCSKQSVPQQFRPRIGDACCARFTGDKNWYRAVVLETSDSEVKVL 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 767963296  967 YADYGNIETLPLCRVQPITSSHLALPFQIIRCSLEG 1002
Cdd:cd20411    81 YADYGNTETLPLSRILPITKSHLELPFQIIRCSLAG 116

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 767963296  517 GRKLAELQASLSKYCDQLPPRSDFYPAIGDICCAQFS 553
Cdd:cd20409     1 GRQLAELQESLSAYCKVAPASSDFSPAVGEVCCAQFT 37

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963296  887 ANVLEIISPNLFYALPKGMPENQEKLCMLTAELLEYCNAPKSRPPYRPRIGDACCAKYTSDDFWYRAVVLGTSDTDVEVL 966
Cdd:cd20411     1 ALVLEVISPDLFYALPKTGQVNVEKLKALMTELAEYCSKQSVPQQFRPRIGDACCARFTGDKNWYRAVVLETSDSEVKVL 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 767963296  967 YADYGNIETLPLCRVQPITSSHLALPFQIIRCSLEG 1002
Cdd:cd20411    81 YADYGNTETLPLSRILPITKSHLELPFQIIRCSLAG 116

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767963296  704 FKAEIGQPCCAFFAGDGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELRMISSTFL 762
Cdd:cd20410     1 FKPIVGEPCCAFFSGDGNWYRAMVKEILPGGAVKVHFVDYGNVEEVTLDKLRKITSTFL 59

Tudor domain;

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963296   264 MEIKGTVTEFKHPGDFYVQlySSEVLEYMNQLSASLKETYANVHEKDYIPVKGEVCIAKYTVDQTWNRAIIQNVDVQQKk 343
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQ--PKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGL- 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 767963296   344 AHVLYIDYGNEEIIPLNRIYHLNRNIDLFPPCAIKCFVAN 383
Cdd:pfam00567   78 VEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117

MYND finger;

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767963296   170 CHRCGLFGS--LRCSQCKQTYYCSTACQRRDWSAHSIVC 206
Cdd:pfam01753    1 CAVCGKEALklLRCSRCKSVYYCSKECQKADWPYHKKEC 39

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 767963296    311 YIPVKGEVCIAKYTvDQTWNRAIIQNVDvQQKKAHVLYIDYGNEEIIPLNRIYHLNR 367
Cdd:smart00333    1 PTFKVGDKVAARWE-DGEWYRARIVKVD-GEQLYEVFFIDYGNEEVVPPSDLRQLPE 55

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963296  887 ANVLEIISPNLFYALPKGMPENQEKLCMLTAELLEYCNAPKSRPPYRPRIGDACCAKYTSDDFWYRAVVLGTSDTDVEVL 966
Cdd:cd20411     1 ALVLEVISPDLFYALPKTGQVNVEKLKALMTELAEYCSKQSVPQQFRPRIGDACCARFTGDKNWYRAVVLETSDSEVKVL 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 767963296  967 YADYGNIETLPLCRVQPITSSHLALPFQIIRCSLEG 1002
Cdd:cd20411    81 YADYGNTETLPLSRILPITKSHLELPFQIIRCSLAG 116

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767963296  704 FKAEIGQPCCAFFAGDGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELRMISSTFL 762
Cdd:cd20410     1 FKPIVGEPCCAFFSGDGNWYRAMVKEILPGGAVKVHFVDYGNVEEVTLDKLRKITSTFL 59

Tudor domain;

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963296   264 MEIKGTVTEFKHPGDFYVQlySSEVLEYMNQLSASLKETYANVHEKDYIPVKGEVCIAKYTVDQTWNRAIIQNVDVQQKk 343
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQ--PKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGL- 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 767963296   344 AHVLYIDYGNEEIIPLNRIYHLNRNIDLFPPCAIKCFVAN 383
Cdd:pfam00567   78 VEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963296  889 VLEIISPNLFYALPKGmPENQEKLCMLTAELLEYCNAPKSRPPYRPRIGDACCAKYTSDDFWYRAVVLGTSDTD--VEVL 966
Cdd:cd20408     3 VTEFKNPGEFYIQIYT-LEVLESLVKLTSQLKKTYASVNNHKEYIPEVGEVCVAKYSEDQNWYRALVQTVDVQQkkAGVF 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 767963296  967 YADYGNIETLPLCRVQPITSSHLALPFQIIRCSLEGLMELNGS 1009
Cdd:cd20408    82 YIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGS 124

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963296  655 VDQTVDVVVCVIYSPGEFYCHVLKEDalKKLNDLNKSLAEHCQQKlpNGFKAEIGQPC---CAFFAGDGSWYRALVKEIL 731
Cdd:cd20437     1 VGTTEKVKITAAVSPSKFYCQLLSWE--PELSKLTTQMTLHYESV--SKELNPSCENFgllCAAKGKDGQWHRGFLQQLL 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 767963296  732 PNGHVKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLAD 775
Cdd:cd20437    77 PPSQVKVWFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSLSC 120

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963296  661 VVVCVIYSPGEFYCHVLKEDALkkLNDLNKSLAEhcQQKLPNGFKAEIGQP--CCAFFAGDGSWYRALVKEILPNGHVKV 738
Cdd:cd20440    14 VYITHVYSPAKFYCQLDRNTEI--LEALMEKIAE--ISKLFNSQILDNCKTrlCLAKYFEDGQWYRALAHPVESSSHLSV 89

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 767963296  739 HFVDYGNIEEVTADELRMISSTFLNL---PFQGIRCQL 773
Cdd:cd20440    90 YFVDYGNKQIVEKNEVLPIPDTAVDLlltPMQAIKCCL 127

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963296  663 VCVIYSPGEFYCHVlkedALKKLNDLNKSLAEHCQQKLPNGFKA---EIGQPCCAFFAGDGSWYRALVKEILPNgHVKVH 739
Cdd:cd20426     5 ATAVDSPEYFWCQF----ATEKIQCLAVKVQEAGEQVADRGNFIpsiYVGDPCIVKYSEDNHWYRALVTKINDN-LVSVR 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767963296  740 FVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLADIQSRNKHWSEEAITRF 791
Cdd:cd20426    80 FVDYGNEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSDEANDYF 131

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963296  683 KKLNDLNKSLAEHCQQK--LPNGFKAEIGQPCCAFFAGDGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELRMISST 760
Cdd:cd20412     4 LQLDKLVQEMTQYYESEenRHTLLTVQVGDIVAAPFRHDGSWYRARVLGFLENGNLDLYFVDYGDSGYVPLEDLRALRSD 83

                          90
                  ....*....|.
gi 767963296  761 FLNLPFQGIRC 771
Cdd:cd20412    84 FLSLPFQAIEC 94

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963296  660 DVVVCVIYSPGEFYCHvLKEDALKkLNDLNKSLAEHCQQ--KLpNGF--KAEIGQPCCAFFAGDGsWYRALVKEILPNGh 735
Cdd:cd20422     3 DAQVEFVKDPSEFWIR-LGEHAVP-FSKLMRSMTAFYSQasKL-DGVvlKPQPGQLCCAKWKEDR-YYRAIVTAVKGKM- 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767963296  736 VKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLADIQSRNKHWSEEAITRFQ 792
Cdd:cd20422    78 VEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGERWSPEAISAFK 134

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767963296  926 PKSRPPYRPRIGDACCAKYTSDDFWYRA-VVLGTSDTDVEVLYADYGNIETLPLCRVQPITSS 987
Cdd:cd20433    20 PPLPGSYTPRKGDLCAAKFVEDGEWYRAkVEKVEGDKKVHVLYIDYGNREVLPSTRLAALPPA 82

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767963296  318 VCIAKYTVDQTWNRAIIQNVDVQQKKAHVLYIDYGNEEIIPLNRIYHLNRNIDLFPPCAIKCFVANVIPAEGN 390
Cdd:cd20423     8 VCLAKYSEDGKWCRALIDNVYEPVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQPSGQ 80

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963296  911 KLCMLTAELLEYCNAPKSRPP--YRPRIGDACCAKYTSDDFWYRAVVLG-------TSDTDVEVLYADYGNIETLPLCRV 981
Cdd:cd20443    13 RLSSIQQQLEGLSLKDKANPPggFNPKKGELVLAQFSADNSWNRAMVVNaprqgtqSPKDEYEVFYIDYGNQETVPLSAL 92

                          90       100
                  ....*....|....*....|..
gi 767963296  982 QPITSSHLALPFQIIRCSLEGL 1003
Cdd:cd20443    93 RPLDPSVSSAPGLAQLCSLAHI 114

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 767963296  517 GRKLAELQASLSKYCDQLPPRSDFYPAIGDICCAQFS 553
Cdd:cd20409     1 GRQLAELQESLSAYCKVAPASSDFSPAVGEVCCAQFT 37

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767963296  315 KGEVCIAKYTVDQTWNRAIIQNVDvQQKKAHVLYIDYGNEEIIPLNRIYHL 365
Cdd:cd20379     1 VGDLCAAKYEEDGKWYRARVLEVL-SNDKVEVFFVDYGNTETVPLSDLRPL 50

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963296  680 DALKKL-NDLNKSLAEHcqQKLPNGFKAEIGQPCCAFFAGDGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELRMIS 758
Cdd:cd20433     3 PQLEKLmEKLRFEIASN--PPLPGSYTPRKGDLCAAKFVEDGEWYRAKVEKVEGDKKVHVLYIDYGNREVLPSTRLAALP 80

                  ...
gi 767963296  759 STF 761
Cdd:cd20433    81 PAF 83

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963296  709 GQPCCAFFAgDGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLADIQS 778
Cdd:cd20415    28 GQACVALFE-DGAWYRARIIGLPGHREVEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKARECRLAFIEP 96

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767963296  711 PCCAFFAGDGSWYRALVKEI-LPNGHVKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLADIQ 777
Cdd:cd20423     8 VCLAKYSEDGKWCRALIDNVyEPVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLI 75

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767963296  936 IGDACCAKYTSDDFWYRAVVLGTSDTD-VEVLYADYGNIETLPLCRVQPI 984
Cdd:cd20379     1 VGDLCAAKYEEDGKWYRARVLEVLSNDkVEVFFVDYGNTETVPLSDLRPL 50

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767963296  932 YRPRIGDACCAKYTSDDFWYRAVVLG-TSDTDVEVLYADYGNIETLPLCRVQPITSSHL 989
Cdd:cd20410     1 FKPIVGEPCCAFFSGDGNWYRAMVKEiLPGGAVKVHFVDYGNVEEVTLDKLRKITSTFL 59

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963296  660 DVVVCVIYSPGEFYCHVLKEDALkkLNDLNKSLAEHCQQKLPNGFKAEIGQPCCAFFAgDGSWYRALVKEILPNghVKVH 739
Cdd:cd20424    15 EVYITYVNDPWTFYCQLARNAGV--LDQLASAISRLSSEIRKLELSVNPGTLCLAKYS-DQHWYRGIIITNKNS--TEVF 89

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 767963296  740 FVDYGNIEEVTADELRMISS---TFLNLPFQGIRCQL 773
Cdd:cd20424    90 FVDYGNTEKVEKEDMLPIPSdayELLLLPMQAIKCSL 126

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963296  652 ELGVDQTVDVVVCVIYSPGEFYCHvlkedaLKKLNDLNKSLAEHCQQ------KLPNGFKAEI-GQPCCAFfAGDGSWYR 724
Cdd:cd20421     6 QLQVGVTETVVVTEVTDPHRIFCQ------LRSLSQELKRLSESMHQyyegrvGSGYETRPEKlGSPCAAR-GSDGRWYR 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 767963296  725 ALVKEILPNGH-VKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQL 773
Cdd:cd20421    79 AVLQQVFSANRvVEVLHVDYGRKEVVSVSNLRYLAPEYFRMPVVTYPCAL 128

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 767963296    709 GQPCCAFFaGDGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELR 755
Cdd:smart00333    6 GDKVAARW-EDGEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLR 51

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963296  892 IISPNLFYAlpkGMPENQEKLCMLTAELLEYCNApkSRPPYRPriGD-ACCAKYTSDDFWYRAVVLG-TSDTDVEVLYAD 969
Cdd:cd20439    19 VNSPGDFWC---QLQTKSSELKSLMKQIQSYYLI--HNDPYKH--GQiACVAKYSKDGKWYRAAVLKqVSAKEVDVIFVD 91