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Conserved domains on  [gi|767902408|ref|XP_011539001|]
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UBX domain-containing protein 10 isoform X1 [Homo sapiens]

Protein Classification

UBX_UBXN10 domain-containing protein( domain architecture ID 13018795)

UBX_UBXN10 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UBX_UBXN10 cd17076
Ubiquitin regulatory domain X (UBX) found in UBX domain protein 10 (UBXN10) and similar ...
 197-272 1.56e-39

Ubiquitin regulatory domain X (UBX) found in UBX domain protein 10 (UBXN10) and similar proteins; UBXN10, also termed UBX domain-containing protein 3 (UBXD3), belongs to the UBXD family of proteins that contains the ubiquitin regulatory domain X (UBX) with a beta-grasp ubiquitin-like fold, but without the C-terminal double glycine motif. UBX domain is typically located at the carboxyl terminus of proteins, and participates broadly in the regulation of protein degradation. UBXN10 functions as a cofactor of p97 (also known as VCP or Cdc48), which is a homohexameric AAA ATPase (ATPase associated with a variety of activities) involved in a variety of functions ranging from cell-cycle regulation to membrane fusion and protein degradation. UBXN10 localizes to cilia in a p97-dependent manner, and both p97 and UBXN10 are required for ciliogenesis. Additionally, UBXN10 interacts with the intraflagellar transport B (IFT-B) and regulates anterograde transport into cilia.


:

Pssm-ID: 340596  Cd Length: 76  Bit Score: 132.37  E-value: 1.56e-39
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767902408 197 PRLLLAVRSPTGQRFVRHFRPTDDLQTIVAVAEQKNKTSYRHCSIETMEVPRRRFSDLTKSLQECRIPHKSVLGIS 272
Cdd:cd17076    1 PRILLAIRLPDGQRFQRFFRPSDTLQDVLAFAESQSGLDLSNCIIETNEVPRRVFSDLSKTIAECGIQDKTVLYIE 76
 
Name Accession Description Interval E-value
UBX_UBXN10 cd17076
Ubiquitin regulatory domain X (UBX) found in UBX domain protein 10 (UBXN10) and similar ...
 197-272 1.56e-39

Ubiquitin regulatory domain X (UBX) found in UBX domain protein 10 (UBXN10) and similar proteins; UBXN10, also termed UBX domain-containing protein 3 (UBXD3), belongs to the UBXD family of proteins that contains the ubiquitin regulatory domain X (UBX) with a beta-grasp ubiquitin-like fold, but without the C-terminal double glycine motif. UBX domain is typically located at the carboxyl terminus of proteins, and participates broadly in the regulation of protein degradation. UBXN10 functions as a cofactor of p97 (also known as VCP or Cdc48), which is a homohexameric AAA ATPase (ATPase associated with a variety of activities) involved in a variety of functions ranging from cell-cycle regulation to membrane fusion and protein degradation. UBXN10 localizes to cilia in a p97-dependent manner, and both p97 and UBXN10 are required for ciliogenesis. Additionally, UBXN10 interacts with the intraflagellar transport B (IFT-B) and regulates anterograde transport into cilia.


Pssm-ID: 340596  Cd Length: 76  Bit Score: 132.37  E-value: 1.56e-39
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767902408 197 PRLLLAVRSPTGQRFVRHFRPTDDLQTIVAVAEQKNKTSYRHCSIETMEVPRRRFSDLTKSLQECRIPHKSVLGIS 272
Cdd:cd17076    1 PRILLAIRLPDGQRFQRFFRPSDTLQDVLAFAESQSGLDLSNCIIETNEVPRRVFSDLSKTIAECGIQDKTVLYIE 76
UBX pfam00789
UBX domain; This domain is present in ubiquitin-regulatory proteins and is a general ...
 196-269 1.28e-06

UBX domain; This domain is present in ubiquitin-regulatory proteins and is a general Cdc48-interacting module.


Pssm-ID: 395637 [Multi-domain]  Cd Length: 80  Bit Score: 45.36  E-value: 1.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902408  196 EPRLLLAVRSPTGQRFVRHFRPTDDLQTIVAVAEQK---NKTSYrhcSIETMeVPRRRFSDLT--KSLQECRI-PHKSVL 269
Cdd:pfam00789   2 EDVTRLQIRLPDGSRLVRRFNSSDKLQTVYDFVDSNrydDLEPF---SLNTP-FPRRPLTDLDysKTLKEAGLlPNSTLV 77
UBX smart00166
Domain present in ubiquitin-regulatory proteins; Present in FAF1 and Shp1p.
 200-260 2.47e-06

Domain present in ubiquitin-regulatory proteins; Present in FAF1 and Shp1p.


Pssm-ID: 197552 [Multi-domain]  Cd Length: 77  Bit Score: 44.60  E-value: 2.47e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767902408   200 LLAVRSPTGQRFVRHFRPTDDLQTIVAVAEQKNKTSYRHCSIETMeVPRRRFS--DLTKSLQE 260
Cdd:smart00166   3 RLQIRLPDGSRLVRRFPSSDTLRTVYEFVSAALGDGNDPFTLNSP-FPRRTFTkdDYSKKLLE 64
 
Name Accession Description Interval E-value
UBX_UBXN10 cd17076
Ubiquitin regulatory domain X (UBX) found in UBX domain protein 10 (UBXN10) and similar ...
 197-272 1.56e-39

Ubiquitin regulatory domain X (UBX) found in UBX domain protein 10 (UBXN10) and similar proteins; UBXN10, also termed UBX domain-containing protein 3 (UBXD3), belongs to the UBXD family of proteins that contains the ubiquitin regulatory domain X (UBX) with a beta-grasp ubiquitin-like fold, but without the C-terminal double glycine motif. UBX domain is typically located at the carboxyl terminus of proteins, and participates broadly in the regulation of protein degradation. UBXN10 functions as a cofactor of p97 (also known as VCP or Cdc48), which is a homohexameric AAA ATPase (ATPase associated with a variety of activities) involved in a variety of functions ranging from cell-cycle regulation to membrane fusion and protein degradation. UBXN10 localizes to cilia in a p97-dependent manner, and both p97 and UBXN10 are required for ciliogenesis. Additionally, UBXN10 interacts with the intraflagellar transport B (IFT-B) and regulates anterograde transport into cilia.


Pssm-ID: 340596  Cd Length: 76  Bit Score: 132.37  E-value: 1.56e-39
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767902408 197 PRLLLAVRSPTGQRFVRHFRPTDDLQTIVAVAEQKNKTSYRHCSIETMEVPRRRFSDLTKSLQECRIPHKSVLGIS 272
Cdd:cd17076    1 PRILLAIRLPDGQRFQRFFRPSDTLQDVLAFAESQSGLDLSNCIIETNEVPRRVFSDLSKTIAECGIQDKTVLYIE 76
UBX cd01767
Ubiquitin regulatory domain X (UBX) structurally similar to a beta-grasp ubiquitin-like fold; ...
 201-269 1.82e-11

Ubiquitin regulatory domain X (UBX) structurally similar to a beta-grasp ubiquitin-like fold; The UBXD family of proteins contains the ubiquitin regulatory domain X (UBX) with a beta-grasp ubiquitin-like fold, but without the C-terminal double glycine motif. UBX domain is typically located at the carboxyl terminus of proteins, and participates broadly in the regulation of protein degradation. Members in this family function as cofactors of p97 (also known as VCP or Cdc48), which is a homohexameric AAA ATPase (ATPase associated with a variety of activities) involved in a variety of functions ranging from cell-cycle regulation to membrane fusion and protein degradation. Based on domain composition, UBXD proteins can be divided into two main groups, with and without ubiquitin-associated (UBA) domain.


Pssm-ID: 340466 [Multi-domain]  Cd Length: 74  Bit Score: 58.81  E-value: 1.82e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767902408 201 LAVRSPTGQRFVRHFRPTDDLQTIVAVAEQKNKTSYRHCSIETMeVPRRRFSDL--TKSLQECRIPHKSVL 269
Cdd:cd01767    2 IQIRLPDGSRIQRRFSKSDTLQDLYDFVESNLGDSPSSFSLVTS-FPRRVLTDEdsDKTLEELGLTPNAVL 71
UBX pfam00789
UBX domain; This domain is present in ubiquitin-regulatory proteins and is a general ...
 196-269 1.28e-06

UBX domain; This domain is present in ubiquitin-regulatory proteins and is a general Cdc48-interacting module.


Pssm-ID: 395637 [Multi-domain]  Cd Length: 80  Bit Score: 45.36  E-value: 1.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902408  196 EPRLLLAVRSPTGQRFVRHFRPTDDLQTIVAVAEQK---NKTSYrhcSIETMeVPRRRFSDLT--KSLQECRI-PHKSVL 269
Cdd:pfam00789   2 EDVTRLQIRLPDGSRLVRRFNSSDKLQTVYDFVDSNrydDLEPF---SLNTP-FPRRPLTDLDysKTLKEAGLlPNSTLV 77
UBX smart00166
Domain present in ubiquitin-regulatory proteins; Present in FAF1 and Shp1p.
 200-260 2.47e-06

Domain present in ubiquitin-regulatory proteins; Present in FAF1 and Shp1p.


Pssm-ID: 197552 [Multi-domain]  Cd Length: 77  Bit Score: 44.60  E-value: 2.47e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767902408   200 LLAVRSPTGQRFVRHFRPTDDLQTIVAVAEQKNKTSYRHCSIETMeVPRRRFS--DLTKSLQE 260
Cdd:smart00166   3 RLQIRLPDGSRLVRRFPSSDTLRTVYEFVSAALGDGNDPFTLNSP-FPRRTFTkdDYSKKLLE 64
UBX_UBXN4 cd16117
Ubiquitin regulatory domain X (UBX) found in UBX domain protein 4 (UBXN4) and similar proteins; ...
 201-260 2.47e-04

Ubiquitin regulatory domain X (UBX) found in UBX domain protein 4 (UBXN4) and similar proteins; UBXN4, also termed ERAD (endoplasmic-reticulum-associated protein degradation) substrate erasing protein (erasin), or UBX domain-containing protein 2 (UBXD2), or UBXDC1, belongs to the UBXD family of proteins that contains the ubiquitin regulatory domain X (UBX) with a beta-grasp ubiquitin-like fold, but without the C-terminal double glycine motif. UBX domain is typically located at the carboxyl terminus of proteins, and participates broadly in the regulation of protein degradation. UBXN4 is an endoplasmic reticulum (ER) localized protein that interacts with p97 (also known as VCP or Cdc48) via its UBX domain. Erasin exists in a complex with other p97/VCP-associated factors involved in endoplasmic-reticulum-associated protein degradation (ERAD). p97 is a homohexameric AAA ATPase (ATPase associated with a variety of activities) involved in a variety of functions ranging from cell-cycle regulation to membrane fusion and protein degradation. The overexpression of UBXN4 increases degradation of a classical ERAD substrate and UBXN4 levels are increased in ER stressed cells. Anti-UBXN4 staining is increased in neuropathological lesions in brains of patients with Alzheimer's disease.


Pssm-ID: 340534 [Multi-domain]  Cd Length: 77  Bit Score: 38.85  E-value: 2.47e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767902408 201 LAVRSPTGQRFVRHFRPTDDLQTIVAVAEQKNKTSYRHCSIETMeVPRRRF--SDLTKSLQE 260
Cdd:cd16117    4 IQFRLPDGSSFTNQFPSDAPLEEARQFVAQTVGPAYGPFSLATT-FPRREFtdDDYQKTLLE 64
UBX_UBXN3A cd01771
Ubiquitin regulatory domain X (UBX) found in FAS associated factor 1 (FAF1, also known as ...
 201-264 8.80e-03

Ubiquitin regulatory domain X (UBX) found in FAS associated factor 1 (FAF1, also known as UBXN3A) and similar proteins; UBX domain-containing protein 3A (UBXN3A),also termed UBX domain-containing protein 12 (UBXD12), or FAF1, belongs to the UBXD family of proteins that contains the ubiquitin regulatory domain X (UBX) with a beta-grasp ubiquitin-like fold, but without the C-terminal double glycine motif. UBX domain is typically located at the carboxyl terminus of proteins, and participates broadly in the regulation of protein degradation. In addition, FAF1 contains two tandem ubiquitin-like (Ubl) domains, which shows high structural similarity with UBX domain. FAF1 functions as a cofactor of p97 (also known as VCP or Cdc48), which is a homohexameric AAA ATPase (ATPase associated with a variety of activities) involved in a variety of functions ranging from cell-cycle regulation to membrane fusion and protein degradation. The FAF1-p97 complex inhibits the proteasomal protein degradation in which p97 acts as a co-chaperone. Moreover, FAF1 is an apoptotic signaling molecule that acts downstream in the Fas signal transduction pathway. It interacts with the cytoplasmic domain of Fas, but not to a Fas mutant that is deficient in signal transduction. FAF1 is widely expressed in adult and embryonic tissues, and in tumor cell lines, and is localized not only in the cytoplasm where it interacts with Fas, but also in the nucleus. FAF1 contains phosphorylation sites for protein kinase CK2 within the nuclear targeting domain. Phosphorylation influences nuclear localization of FAF1 but does not affect its potentiation of Fas-induced apoptosis. Other functions have also been attributed to FAF1. It inhibits nuclear factor-kappaB (NF-kappaB) by interfering with the nuclear translocation of the p65 subunit. Although the precise role of FAF1 in the ubiquitination pathway remains unclear, FAF1 interacts with valosin-containing protein (VCP), which is involved in the ubiquitin-proteosome pathway. This family corresponds to UBX domain.


Pssm-ID: 340469  Cd Length: 80  Bit Score: 34.51  E-value: 8.80e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767902408 201 LAVRSPTGQRFVRHFRPTDDLQTIVAVAEQK--NKTSYRHCSietmEVPRRRFS--DLTKSLQECRIP 264
Cdd:cd01771    7 LRFRLPGGEFLTRRFLASEPLQVLLNFVASKgyPPDEYKLLT----TFPRRDLTqlDPSKTLEELKLF 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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