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Conserved domains on  [gi|767902729|ref|XP_011539140|]
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phospholipid phosphatase-related protein type 5 isoform X1 [Homo sapiens]

Protein Classification

PAP2 phosphatase family protein( domain architecture ID 10130187)

type 2 phosphatidic acid phosphatase (PAP2) family protein similar to phospholipid phosphatase that catalyzes the conversion of phosphatidic acid to diacylglycerol

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
102-251 1.39e-71

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


:

Pssm-ID: 239479  Cd Length: 150  Bit Score: 217.88  E-value: 1.39e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902729 102 RTVRFLGIYTFGLFATDIFVNAGQVVTGNLAPHFLALCKPNYTALGCQQYTQFISGEEACTGNPDLIMRARKTFPSKEAA 181
Cdd:cd03384    1 RLYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSLDHQYIADCTCCTGDPDLIREARLSFPSGHAS 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902729 182 LSVYAAMYLTMYITNTIKAKGTRLAKPVLCLGLMCLAFLTGLNRVAEYRNHWSDVIAGFLVGISIAVFLV 251
Cdd:cd03384   81 LSMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
 
Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
102-251 1.39e-71

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 217.88  E-value: 1.39e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902729 102 RTVRFLGIYTFGLFATDIFVNAGQVVTGNLAPHFLALCKPNYTALGCQQYTQFISGEEACTGNPDLIMRARKTFPSKEAA 181
Cdd:cd03384    1 RLYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSLDHQYIADCTCCTGDPDLIREARLSFPSGHAS 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902729 182 LSVYAAMYLTMYITNTIKAKGTRLAKPVLCLGLMCLAFLTGLNRVAEYRNHWSDVIAGFLVGISIAVFLV 251
Cdd:cd03384   81 LSMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
109-256 5.17e-14

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 67.45  E-value: 5.17e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902729  109 IYTFGLFATDIFVNAGQVVTGNLAPHFLALCKPNYTAlGCQQYTQFISgeeactgnpdlimrarktFPSKEAALSVYAAM 188
Cdd:pfam01569   1 ILLLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVPA-PSTLPGLGYS------------------FPSGHSATAFALAL 61
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767902729  189 YLTMYITNTIKAKgtrlaKPVLCLGLMCLAFLTGLNRVAEYRNHWSDVIAGFLVGISIAVFLVVCVVN 256
Cdd:pfam01569  62 LLALLLRRLRKIV-----RVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVPK 124
acidPPc smart00014
Acid phosphatase homologues;
161-251 5.64e-13

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 64.29  E-value: 5.64e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902729   161 CTGNPDLIMRARKTFPSKEAALSVYAAMYLTMYItntikakGTRLAKPVLCLGLMCLAFLTGLNRVAEYRNHWSDVIAGF 240
Cdd:smart00014  33 CTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLYL-------PARAGRKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGS 105
                           90
                   ....*....|.
gi 767902729   241 LVGISIAVFLV 251
Cdd:smart00014 106 LLGILIAAVLF 116
PLN02250 PLN02250
lipid phosphate phosphatase
112-249 6.82e-13

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 68.03  E-value: 6.82e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902729 112 FGLFATDIFVNAGQVVTGNLAPHFLALCKPNYTALgcqqyTQFISGEEACTGNPDLIMRARKTFPSKEAALSVYAAMYLT 191
Cdd:PLN02250 105 FSVLITGVITDAIKDAVGRPRPDFFWRCFPDGKGV-----FHPVTTDVLCTGAKSVIKEGHKSFPSGHTSWSFAGLGFLS 179
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902729 192 MYITNTIKAKGTRLAKPVLCLGLMCL--AFLTGLNRVAEYRNHWSDVIAGFLVGISIAVF 249
Cdd:PLN02250 180 LYLSGKIRVFDRRGHVAKLCIVFLPLlvAALVGVSRVDDYWHHWQDVFAGALIGLTVASF 239
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
175-251 4.76e-04

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 40.41  E-value: 4.76e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767902729 175 FPSKEAALSvyAAMYLTMYItntikakgtRLAKPVLCLGLMCLAFLTGLNRVaeYRN-HW-SDVIAGFLVGISIAVFLV 251
Cdd:COG0671  119 FPSGHAAAA--FALALVLAL---------LLPRRWLAALLLALALLVGLSRV--YLGvHYpSDVLAGALLGLAIALLLL 184
 
Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
102-251 1.39e-71

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 217.88  E-value: 1.39e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902729 102 RTVRFLGIYTFGLFATDIFVNAGQVVTGNLAPHFLALCKPNYTALGCQQYTQFISGEEACTGNPDLIMRARKTFPSKEAA 181
Cdd:cd03384    1 RLYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSLDHQYIADCTCCTGDPDLIREARLSFPSGHAS 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902729 182 LSVYAAMYLTMYITNTIKAKGTRLAKPVLCLGLMCLAFLTGLNRVAEYRNHWSDVIAGFLVGISIAVFLV 251
Cdd:cd03384   81 LSMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
33-249 2.88e-21

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 89.20  E-value: 2.88e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902729  33 AYRKPYPgpeDSSAVPPVLLYSLAAGVPVLVIIVgetavFCLqLATRDFENQEKTILTgdccyinplvrrtvrflgiYTF 112
Cdd:cd03390    2 SISYPFA---ESETVPTWLLVIISVGIPLLVIIL-----ISL-FFRRSLWDLHTSLLG-------------------LLL 53
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902729 113 GLFATDIFVNAGQVVTGNLAPHFLALCKPNYTALGCQQYTqfisGEEACTGNPDLIMRARKTFPSKEAALSVYAAMYLTM 192
Cdd:cd03390   54 SVSLNGVITNVLKNYAGRPRPDFLARCFPDGGTPSDTLVG----IDICCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSL 129
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767902729 193 YITN--TIKAKGTRLAKPVLCLGLMCLAFLTGLNRVAEYRNHWSDVIAGFLVGISIAVF 249
Cdd:cd03390  130 YLAGklHIFDPRGSSWRLLLALLPLLLAILVAVSRTRDYRHHFSDVIAGSLIGLIIAYL 188
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
104-251 4.93e-14

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 67.49  E-value: 4.93e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902729 104 VRFLGIYTFGLFATDIFVNAGQVVTGNLAPHFLALCKPNYtalgcqqytqfisgeeactgNPDLIMRARKTFPSKEAALS 183
Cdd:cd01610    2 RLLALLLLLALLAGLLLTGVLKYLFGRPRPYFLLRCGPDG--------------------DPLLLTEGGYSFPSGHAAFA 61
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767902729 184 VYAAMYLTMYItntikakGTRLAKPVLCLGLMCLAFLTGLNRVAEYRNHWSDVIAGFLVGISIAVFLV 251
Cdd:cd01610   62 FALALFLALLL-------PRRLLRLLLGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLVL 122
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
109-256 5.17e-14

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 67.45  E-value: 5.17e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902729  109 IYTFGLFATDIFVNAGQVVTGNLAPHFLALCKPNYTAlGCQQYTQFISgeeactgnpdlimrarktFPSKEAALSVYAAM 188
Cdd:pfam01569   1 ILLLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVPA-PSTLPGLGYS------------------FPSGHSATAFALAL 61
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767902729  189 YLTMYITNTIKAKgtrlaKPVLCLGLMCLAFLTGLNRVAEYRNHWSDVIAGFLVGISIAVFLVVCVVN 256
Cdd:pfam01569  62 LLALLLRRLRKIV-----RVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVPK 124
acidPPc smart00014
Acid phosphatase homologues;
161-251 5.64e-13

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 64.29  E-value: 5.64e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902729   161 CTGNPDLIMRARKTFPSKEAALSVYAAMYLTMYItntikakGTRLAKPVLCLGLMCLAFLTGLNRVAEYRNHWSDVIAGF 240
Cdd:smart00014  33 CTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLYL-------PARAGRKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGS 105
                           90
                   ....*....|.
gi 767902729   241 LVGISIAVFLV 251
Cdd:smart00014 106 LLGILIAAVLF 116
PLN02250 PLN02250
lipid phosphate phosphatase
112-249 6.82e-13

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 68.03  E-value: 6.82e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902729 112 FGLFATDIFVNAGQVVTGNLAPHFLALCKPNYTALgcqqyTQFISGEEACTGNPDLIMRARKTFPSKEAALSVYAAMYLT 191
Cdd:PLN02250 105 FSVLITGVITDAIKDAVGRPRPDFFWRCFPDGKGV-----FHPVTTDVLCTGAKSVIKEGHKSFPSGHTSWSFAGLGFLS 179
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902729 192 MYITNTIKAKGTRLAKPVLCLGLMCL--AFLTGLNRVAEYRNHWSDVIAGFLVGISIAVF 249
Cdd:PLN02250 180 LYLSGKIRVFDRRGHVAKLCIVFLPLlvAALVGVSRVDDYWHHWQDVFAGALIGLTVASF 239
PLN02715 PLN02715
lipid phosphate phosphatase
112-249 6.95e-13

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 68.16  E-value: 6.95e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902729 112 FGLFATDIFVNAGQVVTGNLAPHFLALCKPNytalGCQQYTQFisGEEACTGNPDLIMRARKTFPSKEAALSVYAAMYLT 191
Cdd:PLN02715 130 FAVLITGVITDSIKVATGRPRPNFYWRCFPD----GKELYDAL--GGVICHGKAAEVKEGHKSFPSGHTSWSFAGLTFLS 203
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902729 192 MYITNTIKAKGTRLAKPVLCLGLMCL--AFLTGLNRVAEYRNHWSDVIAGFLVGISIAVF 249
Cdd:PLN02715 204 LYLSGKIKAFNGEGHVAKLCLVIFPLlaACLVGISRVDDYWHHWQDVFAGALIGILVAAF 263
PLN02731 PLN02731
Putative lipid phosphate phosphatase
112-244 3.22e-11

Putative lipid phosphate phosphatase


Pssm-ID: 178332  Cd Length: 333  Bit Score: 63.12  E-value: 3.22e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902729 112 FGLFATDIFVNAGQVVTGNLAPHFLALCKPNYTALgcqqYTQFisGEEACTGNPDLIMRARKTFPSKEAALSVYAAMYLT 191
Cdd:PLN02731 124 YSVLVTAVLTDAIKNAVGRPRPDFFWRCFPDGKAL----YDSL--GDVICHGDKSVIREGHKSFPSGHTSWSFSGLGFLS 197
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767902729 192 MYITNTIKAKGTRLAKPVLCLGLMCLAF--LTGLNRVAEYRNHWSDVIAGFLVGI 244
Cdd:PLN02731 198 LYLSGKIQAFDGKGHVAKLCIVILPLLFaaLVGISRVDDYWHHWQDVFAGGLLGL 252
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
175-251 4.76e-04

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 40.41  E-value: 4.76e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767902729 175 FPSKEAALSvyAAMYLTMYItntikakgtRLAKPVLCLGLMCLAFLTGLNRVaeYRN-HW-SDVIAGFLVGISIAVFLV 251
Cdd:COG0671  119 FPSGHAAAA--FALALVLAL---------LLPRRWLAALLLALALLVGLSRV--YLGvHYpSDVLAGALLGLAIALLLL 184
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
175-250 4.98e-04

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 40.28  E-value: 4.98e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767902729 175 FPSKEAALSVYAAMYLTMYITNTIKAKGTRLAKPVLCLGLmclAFLTGLNRVaeYRN-HW-SDVIAGFLVGISIAVFL 250
Cdd:cd03392  103 FPSGHAMGATVLYGFLAYLLARRLPRRRVRILLLILAAIL---ILLVGLSRL--YLGvHYpSDVLAGWLLGLAWLALL 175
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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