NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767903200|ref|XP_011539330|]
View 

WD repeat-containing protein 47 isoform X5 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
606-917 2.86e-53

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 191.28  E-value: 2.86e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903200 606 TQAVRAVAFHPAGGLYAVGSNSKTLRVcaypdvIDPSAHETPKQPvvrfkrnKHHKGSIYCVAWSPCGQLLATGSNDKYV 685
Cdd:COG2319   78 TAAVLSVAFSPDGRLLASASADGTVRL------WDLATGLLLRTL-------TGHTGAVRSVAFSPDGKTLASGSADGTV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903200 686 KVLPFNAETCNATVSGpdlefsmHDGTIRDLAFmegpeSG-GAILISAGAgDCNIYTTDCQRGQGLHALSGHTGHILALy 764
Cdd:COG2319  145 RLWDLATGKLLRTLTG-------HSGAVTSVAF-----SPdGKLLASGSD-DGTVRLWDLATGKLLRTLTGHTGAVRSV- 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903200 765 TWS--GWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHP 842
Cdd:COG2319  211 AFSpdGKLLASGSADGTVRLWDLATGKLLR----TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG 286

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767903200 843 HSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ-GDLTKQLPimvvgEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 917
Cdd:COG2319  287 HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLT-----GHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 45-102 8.33e-13

C-terminal to LisH motif; Alpha-helical motif of unknown function.


:

Pssm-ID: 128914  Cd Length: 58  Bit Score: 63.74  E-value: 8.33e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 767903200    45 FSDDMLFLRQLILDGQWDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMS 102
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERNSKLEFELRKQKFLELVRQGKLEE 58
LisH_TPL super family cl39307
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ...
 13-40 2.61e-05

LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.


The actual alignment was detected with superfamily member pfam17814:

Pssm-ID: 375350  Cd Length: 30  Bit Score: 41.61  E-value: 2.61e-05
                          10        20
                  ....*....|....*....|....*...
gi 767903200   13 EIIKLILDFLNSKKLHISMLALEKESGV 40
Cdd:pfam17814   3 DVVRLILQFLKENGLHRTLQALQTESGV 30
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
606-917 2.86e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 191.28  E-value: 2.86e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903200 606 TQAVRAVAFHPAGGLYAVGSNSKTLRVcaypdvIDPSAHETPKQPvvrfkrnKHHKGSIYCVAWSPCGQLLATGSNDKYV 685
Cdd:COG2319   78 TAAVLSVAFSPDGRLLASASADGTVRL------WDLATGLLLRTL-------TGHTGAVRSVAFSPDGKTLASGSADGTV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903200 686 KVLPFNAETCNATVSGpdlefsmHDGTIRDLAFmegpeSG-GAILISAGAgDCNIYTTDCQRGQGLHALSGHTGHILALy 764
Cdd:COG2319  145 RLWDLATGKLLRTLTG-------HSGAVTSVAF-----SPdGKLLASGSD-DGTVRLWDLATGKLLRTLTGHTGAVRSV- 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903200 765 TWS--GWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHP 842
Cdd:COG2319  211 AFSpdGKLLASGSADGTVRLWDLATGKLLR----TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG 286

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767903200 843 HSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ-GDLTKQLPimvvgEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 917
Cdd:COG2319  287 HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLT-----GHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 606-917 5.40e-51

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 180.99  E-value: 5.40e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903200 606 TQAVRAVAFHPAGGLYAVGSNSKTLRVCaypDVIDPSAHETPKQpvvrfkrnkhHKGSIYCVAWSPCGQLLATGSNDKYV 685
Cdd:cd00200    9 TGGVTCVAFSPDGKLLATGSGDGTIKVW---DLETGELLRTLKG----------HTGPVRDVAASADGTYLASGSSDKTI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903200 686 KVLPFNAETCNATVSGpdlefsmHDGTIRDLAFMEGPEsggaiLISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-Y 764
Cdd:cd00200   76 RLWDLETGECVRTLTG-------HTSYVSSVAFSPDGR-----ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVaF 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903200 765 TWSGWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHS 844
Cdd:cd00200  144 SPDGTFVASSSQDGTIKLWDLRTGKCVA----TLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHE 219

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767903200 845 SDVRSVRFSPGAHYLLTGSYDMKIKVTDLQgdltKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 917
Cdd:cd00200  220 NGVNSVAFSPDGYLLASGSEDGTIRVWDLR----TGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 45-102 8.33e-13

C-terminal to LisH motif; Alpha-helical motif of unknown function.


Pssm-ID: 128914  Cd Length: 58  Bit Score: 63.74  E-value: 8.33e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 767903200    45 FSDDMLFLRQLILDGQWDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMS 102
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERNSKLEFELRKQKFLELVRQGKLEE 58
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 658-687 1.80e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 1.80e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 767903200   658 KHHKGSIYCVAWSPCGQLLATGSNDKYVKV 687
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKL 38
WD40 pfam00400
WD domain, G-beta repeat;
658-687 1.61e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 1.61e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 767903200  658 KHHKGSIYCVAWSPCGQLLATGSNDKYVKV 687
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKV 37
LisH_TPL pfam17814
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ...
 13-40 2.61e-05

LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.


Pssm-ID: 375350  Cd Length: 30  Bit Score: 41.61  E-value: 2.61e-05
                          10        20
                  ....*....|....*....|....*...
gi 767903200   13 EIIKLILDFLNSKKLHISMLALEKESGV 40
Cdd:pfam17814   3 DVVRLILQFLKENGLHRTLQALQTESGV 30
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 9-42 3.20e-03

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 35.87  E-value: 3.20e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 767903200     9 VKEVEIIKLILDFLNSKKLHISMLALEKESGVIN 42
Cdd:smart00667   1 ISRSELNRLILEYLLRNGYEETAETLQKESGLSL 34
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
606-917 2.86e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 191.28  E-value: 2.86e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903200 606 TQAVRAVAFHPAGGLYAVGSNSKTLRVcaypdvIDPSAHETPKQPvvrfkrnKHHKGSIYCVAWSPCGQLLATGSNDKYV 685
Cdd:COG2319   78 TAAVLSVAFSPDGRLLASASADGTVRL------WDLATGLLLRTL-------TGHTGAVRSVAFSPDGKTLASGSADGTV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903200 686 KVLPFNAETCNATVSGpdlefsmHDGTIRDLAFmegpeSG-GAILISAGAgDCNIYTTDCQRGQGLHALSGHTGHILALy 764
Cdd:COG2319  145 RLWDLATGKLLRTLTG-------HSGAVTSVAF-----SPdGKLLASGSD-DGTVRLWDLATGKLLRTLTGHTGAVRSV- 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903200 765 TWS--GWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHP 842
Cdd:COG2319  211 AFSpdGKLLASGSADGTVRLWDLATGKLLR----TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG 286

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767903200 843 HSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ-GDLTKQLPimvvgEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 917
Cdd:COG2319  287 HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLT-----GHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
606-917 1.82e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 188.97  E-value: 1.82e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903200 606 TQAVRAVAFHPAGGLYAVGSNSKTLRVCaypDVIDPSAHETPKqpvvrfkrnkHHKGSIYCVAWSPCGQLLATGSNDKYV 685
Cdd:COG2319  120 TGAVRSVAFSPDGKTLASGSADGTVRLW---DLATGKLLRTLT----------GHSGAVTSVAFSPDGKLLASGSDDGTV 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903200 686 KVLPFNAETCNATVSGpdlefsmHDGTIRDLAFmeGPEsgGAILISAGAgDCNIYTTDCQRGQGLHALSGHTGHILALyT 765
Cdd:COG2319  187 RLWDLATGKLLRTLTG-------HTGAVRSVAF--SPD--GKLLASGSA-DGTVRLWDLATGKLLRTLTGHSGSVRSV-A 253

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903200 766 WS--GWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPH 843
Cdd:COG2319  254 FSpdGRLLASGSADGTVRLWDLATGELLR----TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGH 329

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767903200 844 SSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGdltkQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 917
Cdd:COG2319  330 TGAVRSVAFSPDGKTLASGSDDGTVRLWDLAT----GELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 606-917 5.40e-51

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 180.99  E-value: 5.40e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903200 606 TQAVRAVAFHPAGGLYAVGSNSKTLRVCaypDVIDPSAHETPKQpvvrfkrnkhHKGSIYCVAWSPCGQLLATGSNDKYV 685
Cdd:cd00200    9 TGGVTCVAFSPDGKLLATGSGDGTIKVW---DLETGELLRTLKG----------HTGPVRDVAASADGTYLASGSSDKTI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903200 686 KVLPFNAETCNATVSGpdlefsmHDGTIRDLAFMEGPEsggaiLISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-Y 764
Cdd:cd00200   76 RLWDLETGECVRTLTG-------HTSYVSSVAFSPDGR-----ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVaF 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903200 765 TWSGWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHS 844
Cdd:cd00200  144 SPDGTFVASSSQDGTIKLWDLRTGKCVA----TLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHE 219

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767903200 845 SDVRSVRFSPGAHYLLTGSYDMKIKVTDLQgdltKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 917
Cdd:cd00200  220 NGVNSVAFSPDGYLLASGSEDGTIRVWDLR----TGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
606-875 1.10e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 172.40  E-value: 1.10e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903200 606 TQAVRAVAFHPAGGLYAVGSNSKTLRVCaypDVIDPsahetpkQPVVRFKrnkHHKGSIYCVAWSPCGQLLATGSNDKYV 685
Cdd:COG2319  162 SGAVTSVAFSPDGKLLASGSDDGTVRLW---DLATG-------KLLRTLT---GHTGAVRSVAFSPDGKLLASGSADGTV 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903200 686 KVLPFNAETCNATVSGpdlefsmHDGTIRDLAFMegpeSGGAILISAGAgDCNIYTTDCQRGQGLHALSGHTGHILALyT 765
Cdd:COG2319  229 RLWDLATGKLLRTLTG-------HSGSVRSVAFS----PDGRLLASGSA-DGTVRLWDLATGELLRTLTGHSGGVNSV-A 295

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903200 766 WS--GWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPH 843
Cdd:COG2319  296 FSpdGKLLASGSDDGTVRLWDLATGKLLR----TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGH 371

                        250       260       270
                 ....*....|....*....|....*....|..
gi 767903200 844 SSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQG 875
Cdd:COG2319  372 TGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 660-917 2.88e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 161.73  E-value: 2.88e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903200 660 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATVSGpdlefsmHDGTIRDLAFMEgpeSGGAILISAGAGDCNI 739
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG-------HTGPVRDVAASA---DGTYLASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903200 740 YttDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTVRFWDLRVPSCVrvvgTTFHGTGSAVASVAVDPSGRLLA 818
Cdd:cd00200   78 W--DLETGECVRTLTGHTSYVSSVaFSPDGRILSSSSRDKTIKVWDVETGKCL----TTLRGHTDWVNSVAFSPDGTFVA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903200 819 TGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ-GDLTKQLPimvvgEHKDKVIQCR 897
Cdd:cd00200  152 SSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLStGKCLGTLR-----GHENGVNSVA 226

                        250       260
                 ....*....|....*....|
gi 767903200 898 WHTQDLSFLSSSADRTVTLW 917
Cdd:cd00200  227 FSPDGYLLASGSEDGTIRVW 246
WD40 COG2319
WD40 repeat [General function prediction only];
606-917 4.44e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 162.00  E-value: 4.44e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903200 606 TQAVRAVAFHPAGGLYAVGSNSKTLRVcaypdvidpsaheTPKQPVVRFKRNKHHKGSIYCVAWSPCGQLLATGSNDKYV 685
Cdd:COG2319   36 AAAVASLAASPDGARLAAGAGDLTLLL-------------LDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTV 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903200 686 KVLPFNAETCNATVSGpdlefsmHDGTIRDLAFmegpESGGAILISAGAgDCNIYTTDCQRGQGLHALSGHTGHILALyT 765
Cdd:COG2319  103 RLWDLATGLLLRTLTG-------HTGAVRSVAF----SPDGKTLASGSA-DGTVRLWDLATGKLLRTLTGHSGAVTSV-A 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903200 766 WS--GWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPH 843
Cdd:COG2319  170 FSpdGKLLASGSDDGTVRLWDLATGKLLR----TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGH 245

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767903200 844 SSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLpimvVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 917
Cdd:COG2319  246 SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRT----LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 599-830 6.84e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 126.30  E-value: 6.84e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903200 599 CINILED-TQAVRAVAFHPAGGLYAVGSNSKTLRVcaypdvidpsaHETPK-QPVVRFKrnkHHKGSIYCVAWSPCGQLL 676
Cdd:cd00200   85 CVRTLTGhTSYVSSVAFSPDGRILSSSSRDKTIKV-----------WDVETgKCLTTLR---GHTDWVNSVAFSPDGTFV 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903200 677 ATGSNDKYVKVLPFNAETCNATvsgpdleFSMHDGTIRDLAFMEgpeSGGAILISAGAGDCNIYttDCQRGQGLHALSGH 756
Cdd:cd00200  151 ASSSQDGTIKLWDLRTGKCVAT-------LTGHTGEVNSVAFSP---DGEKLLSSSSDGTIKLW--DLSTGKCLGTLRGH 218

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767903200 757 TGHILAL-YTWSGWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYD 830
Cdd:cd00200  219 ENGVNSVaFSPDGYLLASGSEDGTIRVWDLRTGECVQ----TLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
605-833 3.63e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.23  E-value: 3.63e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903200 605 DTQAVRAVAFHPAGGLYAVGSNSKTLRVCaypDVidpsaheTPKQPVVRFkrnKHHKGSIYCVAWSPCGQLLATGSNDKY 684
Cdd:COG2319  245 HSGSVRSVAFSPDGRLLASGSADGTVRLW---DL-------ATGELLRTL---TGHSGGVNSVAFSPDGKLLASGSDDGT 311

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903200 685 VKVlpFNAETcnatvsgpdlefsmhdgtirdlafmegpesggailisagagdcniyttdcqrGQGLHALSGHTGHILALy 764
Cdd:COG2319  312 VRL--WDLAT----------------------------------------------------GKLLRTLTGHTGAVRSV- 336

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767903200 765 TWS--GWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRG 833
Cdd:COG2319  337 AFSpdGKTLASGSDDGTVRLWDLATGELLR----TLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 596-784 5.25e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.41  E-value: 5.25e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903200 596 QFVCINILED-TQAVRAVAFHPAGGLYAVGSNSKTLRVCaypdviDPSAHETpkqpvvrFKRNKHHKGSIYCVAWSPCGQ 674
Cdd:cd00200  124 TGKCLTTLRGhTDWVNSVAFSPDGTFVASSSQDGTIKLW------DLRTGKC-------VATLTGHTGEVNSVAFSPDGE 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903200 675 LLATGSNDKYVKVLPFNAETCNATVSGpdlefsmHDGTIRDLAFMEGPEsggaiLISAGAGDCNIYTTDCQRGQGLHALS 754
Cdd:cd00200  191 KLLSSSSDGTIKLWDLSTGKCLGTLRG-------HENGVNSVAFSPDGY-----LLASGSEDGTIRVWDLRTGECVQTLS 258

                        170       180       190
                 ....*....|....*....|....*....|..
gi 767903200 755 GHTGHILALyTWS--GWMIASGSQDKTVRFWD 784
Cdd:cd00200  259 GHTNSVTSL-AWSpdGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 797-917 2.70e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.54  E-value: 2.70e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903200 797 TFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQgd 876
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE-- 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 767903200 877 lTKQLPIMVVGeHKDKVIQCRWHTQDLSFLSSSADRTVTLW 917
Cdd:cd00200   82 -TGECVRTLTG-HTSYVSSVAFSPDGRILSSSSRDKTIKVW 120
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 45-102 8.33e-13

C-terminal to LisH motif; Alpha-helical motif of unknown function.


Pssm-ID: 128914  Cd Length: 58  Bit Score: 63.74  E-value: 8.33e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 767903200    45 FSDDMLFLRQLILDGQWDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMS 102
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERNSKLEFELRKQKFLELVRQGKLEE 58
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 843-921 7.14e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.28  E-value: 7.14e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767903200 843 HSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLtkqlPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLWTYNG 921
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE----LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 658-687 1.80e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 1.80e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 767903200   658 KHHKGSIYCVAWSPCGQLLATGSNDKYVKV 687
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKL 38
WD40 pfam00400
WD domain, G-beta repeat;
658-687 1.61e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 1.61e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 767903200  658 KHHKGSIYCVAWSPCGQLLATGSNDKYVKV 687
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKV 37
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 834-872 2.42e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 2.42e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767903200   834 GRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTD 872
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
834-872 8.44e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 8.44e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767903200  834 GRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTD 872
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 747-784 1.49e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 1.49e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767903200   747 GQGLHALSGHTGHILALyTWS--GWMIASGSQDKTVRFWD 784
Cdd:smart00320   2 GELLKTLKGHTGPVTSV-AFSpdGKYLASGSDDGTIKLWD 40
LisH_TPL pfam17814
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ...
 13-40 2.61e-05

LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.


Pssm-ID: 375350  Cd Length: 30  Bit Score: 41.61  E-value: 2.61e-05
                          10        20
                  ....*....|....*....|....*...
gi 767903200   13 EIIKLILDFLNSKKLHISMLALEKESGV 40
Cdd:pfam17814   3 DVVRLILQFLKENGLHRTLQALQTESGV 30
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 792-847 7.46e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.57  E-value: 7.46e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767903200  792 RVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDV 847
Cdd:pfam12894  28 RVWTLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLI 83
WD40 pfam00400
WD domain, G-beta repeat;
750-784 9.17e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 9.17e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 767903200  750 LHALSGHTGHILAL-YTWSGWMIASGSQDKTVRFWD 784
Cdd:pfam00400   4 LKTLEGHTGSVTSLaFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 797-830 1.41e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.41e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 767903200   797 TFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYD 830
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
796-830 1.92e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 1.92e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767903200  796 TTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYD 830
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 9-42 3.20e-03

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 35.87  E-value: 3.20e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 767903200     9 VKEVEIIKLILDFLNSKKLHISMLALEKESGVIN 42
Cdd:smart00667   1 ISRSELNRLILEYLLRNGYEETAETLQKESGLSL 34
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 882-917 4.37e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 4.37e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 767903200   882 PIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 917
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH