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Conserved domains on  [gi|767903246|ref|XP_011539348|]
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aflatoxin B1 aldehyde reductase member 3 isoform X1 [Homo sapiens]

Protein Classification

aldo/keto reductase family protein( domain architecture ID 14442332)

aldo/keto reductase family protein is an oxidoreductase that may catalyze the reduction of aldehydes and/or ketones to their corresponding primary and/or secondary alcohols

CATH:  3.20.20.100
EC:  1.-.-.-
Gene Ontology:  GO:0016491
PubMed:  25304492|19706366|9307009|12663943|16970545

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AKR_AKR7A1-5 cd19075
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ...
 10-281 1.75e-155

AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.


:

Pssm-ID: 381301 [Multi-domain]  Cd Length: 304  Bit Score: 439.30  E-value: 1.75e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  10 PATVLGAMEMG---RRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLrlggSDCRVKIDTKAIPLFGNSL 86
Cdd:cd19075    1 PKIILGTMTFGsqgRFTTAEAAAELLDAFLERGHTEIDTARVYPDGTSEELLGELGL----GERGFKIDTKANPGVGGGL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  87 KPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPT 166
Cdd:cd19075   77 SPENVRKQLETSLKRLKVDKVDVFYLHAPDRSTPLEETLAAIDELYKEGKFKEFGLSNYSAWEVAEIVEICKENGWVLPT 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 167 VYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYKYEDKngKQPVGRFFGNT-WAEMYRNRYWKEHHFEGI 245
Cdd:cd19075  157 VYQGMYNAITRQVETELFPCLRKLGIRFYAYSPLAGGFLTGKYKYSED--KAGGGRFDPNNaLGKLYRDRYWKPSYFEAL 234

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 767903246 246 ALVEKALQaaygASAPSMTSATLRWMYHHSQLQVQN 281
Cdd:cd19075  235 EKVEEAAE----KEGISLAEAALRWLYHHSALDGEK 266
 
Name Accession Description Interval E-value
AKR_AKR7A1-5 cd19075
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ...
 10-281 1.75e-155

AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.


Pssm-ID: 381301 [Multi-domain]  Cd Length: 304  Bit Score: 439.30  E-value: 1.75e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  10 PATVLGAMEMG---RRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLrlggSDCRVKIDTKAIPLFGNSL 86
Cdd:cd19075    1 PKIILGTMTFGsqgRFTTAEAAAELLDAFLERGHTEIDTARVYPDGTSEELLGELGL----GERGFKIDTKANPGVGGGL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  87 KPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPT 166
Cdd:cd19075   77 SPENVRKQLETSLKRLKVDKVDVFYLHAPDRSTPLEETLAAIDELYKEGKFKEFGLSNYSAWEVAEIVEICKENGWVLPT 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 167 VYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYKYEDKngKQPVGRFFGNT-WAEMYRNRYWKEHHFEGI 245
Cdd:cd19075  157 VYQGMYNAITRQVETELFPCLRKLGIRFYAYSPLAGGFLTGKYKYSED--KAGGGRFDPNNaLGKLYRDRYWKPSYFEAL 234

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 767903246 246 ALVEKALQaaygASAPSMTSATLRWMYHHSQLQVQN 281
Cdd:cd19075  235 EKVEEAAE----KEGISLAEAALRWLYHHSALDGEK 266
PdxI COG0667
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ...
 14-275 5.69e-53

Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440431 [Multi-domain]  Cd Length: 316  Bit Score: 178.06  E-value: 5.69e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  14 LGAMEMGR---RMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDcrVKIDTKAIPLFGNS----- 85
Cdd:COG0667   18 LGTMTFGGpwgGVDEAEAIAILDAALDAGINFFDTADVYGPGRSEELLGEALKGRPRDD--VVIATKVGRRMGPGpngrg 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  86 LKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKsnGWILP 165
Cdd:COG0667   96 LSREHIRRAVEASLRRLGTDYIDLYQLHRPDPDTPIEETLGALDELVREGKIRYIGVSNYSAEQLRRALAIAE--GLPPI 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 166 TVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYKYEDKNGKqpvgrffGNTWAEMYRNRYWKEHHFEGI 245
Cdd:COG0667  174 VAVQNEYSLLDRSAEEELLPAARELGVGVLAYSPLAGGLLTGKYRRGATFPE-------GDRAATNFVQGYLTERNLALV 246

                        250       260       270
                 ....*....|....*....|....*....|
gi 767903246 246 ALVeKALQAAYGASAPSMtsAtLRWMYHHS 275
Cdd:COG0667  247 DAL-RAIAAEHGVTPAQL--A-LAWLLAQP 272
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
 13-275 2.53e-42

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 149.38  E-value: 2.53e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246   13 VLGAMEMG---RRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKAIPLFGN---SL 86
Cdd:pfam00248   2 GLGTWQLGggwGPISKEEALEALRAALEAGINFIDTAEVYGDGKSEELLGEALKDYPVKRDKVVIATKVPDGDGPwpsGG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246   87 KPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEIctlcKSNGWILPT 166
Cdd:pfam00248  82 SKENIRKSLEESLKRLGTDYIDLYYLHWPDPDTPIEETWDALEELKKEGKIRAIGVSNFDAEQIEKA----LTKGKIPIV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  167 VYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYKYEDKNGKQPVGRFFGNTWAEMYrnrywkehhfEGIA 246
Cdd:pfam00248 158 AVQVEYNLLRRRQEEELLEYCKKNGIPLIAYSPLGGGLLTGKYTRDPDKGPGERRRLLKKGTPLNL----------EALE 227

                         250       260
                  ....*....|....*....|....*....
gi 767903246  247 LVEKaLQAAYGAsapSMTSATLRWMYHHS 275
Cdd:pfam00248 228 ALEE-IAKEHGV---SPAQVALRWALSKP 252
PRK09912 PRK09912
L-glyceraldehyde 3-phosphate reductase; Provisional
 95-209 7.02e-19

L-glyceraldehyde 3-phosphate reductase; Provisional


Pssm-ID: 182140 [Multi-domain]  Cd Length: 346  Bit Score: 86.58  E-value: 7.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  95 LETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSngWILP-TVYQGMYN 173
Cdd:PRK09912 120 LDQSLKRMGLEYVDIFYSHRVDENTPMEETASALAHAVQSGKALYVGISSYSPERTQKMVELLRE--WKIPlLIHQPSYN 197

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 767903246 174 AITRQVE-TELFPCLRHFGLRFYAFNPLAGGLLTGKY 209
Cdd:PRK09912 198 LLNRWVDkSGLLDTLQNNGVGCIAFTPLAQGLLTGKY 234
 
Name Accession Description Interval E-value
AKR_AKR7A1-5 cd19075
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ...
 10-281 1.75e-155

AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.


Pssm-ID: 381301 [Multi-domain]  Cd Length: 304  Bit Score: 439.30  E-value: 1.75e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  10 PATVLGAMEMG---RRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLrlggSDCRVKIDTKAIPLFGNSL 86
Cdd:cd19075    1 PKIILGTMTFGsqgRFTTAEAAAELLDAFLERGHTEIDTARVYPDGTSEELLGELGL----GERGFKIDTKANPGVGGGL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  87 KPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPT 166
Cdd:cd19075   77 SPENVRKQLETSLKRLKVDKVDVFYLHAPDRSTPLEETLAAIDELYKEGKFKEFGLSNYSAWEVAEIVEICKENGWVLPT 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 167 VYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYKYEDKngKQPVGRFFGNT-WAEMYRNRYWKEHHFEGI 245
Cdd:cd19075  157 VYQGMYNAITRQVETELFPCLRKLGIRFYAYSPLAGGFLTGKYKYSED--KAGGGRFDPNNaLGKLYRDRYWKPSYFEAL 234

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 767903246 246 ALVEKALQaaygASAPSMTSATLRWMYHHSQLQVQN 281
Cdd:cd19075  235 EKVEEAAE----KEGISLAEAALRWLYHHSALDGEK 266
AKR_SF cd06660
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ...
 10-204 1.27e-54

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.


Pssm-ID: 381296 [Multi-domain]  Cd Length: 232  Bit Score: 179.64  E-value: 1.27e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  10 PATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDcRVKIDTKAIPLFGNS---- 85
Cdd:cd06660    1 SRLGLGTMTFGGDGDEEEAFALLDAALEAGGNFFDTADVYGDGRSERLLGRWLKGRGNRD-DVVIATKGGHPPGGDpsrs 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  86 -LKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWIL 164
Cdd:cd06660   80 rLSPEHIRRDLEESLRRLGTDYIDLYYLHRDDPSTPVEETLEALNELVREGKIRYIGVSNWSAERLAEALAYAKAHGLPG 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 767903246 165 PTVYQGMYNAITRQV-ETELFPCLRHFGLRFYAFNPLAGGL 204
Cdd:cd06660  160 FAAVQPQYSLLDRSPmEEELLDWAEENGLPLLAYSPLARGP 200
PdxI COG0667
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ...
 14-275 5.69e-53

Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440431 [Multi-domain]  Cd Length: 316  Bit Score: 178.06  E-value: 5.69e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  14 LGAMEMGR---RMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDcrVKIDTKAIPLFGNS----- 85
Cdd:COG0667   18 LGTMTFGGpwgGVDEAEAIAILDAALDAGINFFDTADVYGPGRSEELLGEALKGRPRDD--VVIATKVGRRMGPGpngrg 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  86 LKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKsnGWILP 165
Cdd:COG0667   96 LSREHIRRAVEASLRRLGTDYIDLYQLHRPDPDTPIEETLGALDELVREGKIRYIGVSNYSAEQLRRALAIAE--GLPPI 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 166 TVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYKYEDKNGKqpvgrffGNTWAEMYRNRYWKEHHFEGI 245
Cdd:COG0667  174 VAVQNEYSLLDRSAEEELLPAARELGVGVLAYSPLAGGLLTGKYRRGATFPE-------GDRAATNFVQGYLTERNLALV 246

                        250       260       270
                 ....*....|....*....|....*....|
gi 767903246 246 ALVeKALQAAYGASAPSMtsAtLRWMYHHS 275
Cdd:COG0667  247 DAL-RAIAAEHGVTPAQL--A-LAWLLAQP 272
AKR_AKR12A1_B1_C1 cd19087
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ...
 14-266 3.71e-52

AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.


Pssm-ID: 381313 [Multi-domain]  Cd Length: 310  Bit Score: 175.84  E-value: 3.71e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  14 LGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGlrlggSDCR--VKIDTKA-------IPLFGN 84
Cdd:cd19087   18 LGTMNFGGRTDEETSFAIMDRALDAGINFFDTADVYGGGRSEEIIGRWI-----AGRRddIVLATKVfgpmgddPNDRGL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  85 SLKpdSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWIL 164
Cdd:cd19087   93 SRR--HIRRAVEASLRRLQTDYIDLYQMHHFDRDTPLEETLRALDDLVRQGKIRYIGVSNFAAWQIAKAQGIAARRGLLR 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 165 PTVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYKyedKNGKQPVGRFFGNtwaEMYRNRYWKEHHFE- 243
Cdd:cd19087  171 FVSEQPMYNLLKRQAELEILPAARAYGLGVIPYSPLAGGLLTGKYG---KGKRPESGRLVER---ARYQARYGLEEYRDi 244

                        250       260       270
                 ....*....|....*....|....*....|....
gi 767903246 244 -----------GIALVEKALqaAYGASAPSMTSA 266
Cdd:cd19087  245 aerfealaaeaGLTPASLAL--AWVLSHPAVTSP 276
AKR_AKR9A_9B cd19080
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ...
 14-269 2.43e-45

AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.


Pssm-ID: 381306 [Multi-domain]  Cd Length: 307  Bit Score: 157.77  E-value: 2.43e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  14 LGAM----EMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGsdcRVKIDTKaiplFGNSLKPD 89
Cdd:cd19080   15 LGTMtfgtEWGWGADREEARAMFDAYVEAGGNFIDTANNYTNGTSERLLGEFIAGNRD---RIVLATK----YTMNRRPG 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  90 ----------SLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKS 159
Cdd:cd19080   88 dpnaggnhrkNLRRSVEASLRRLQTDYIDLLYVHAWDFTTPVEEVMRALDDLVRAGKVLYVGISDTPAWVVARANTLAEL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 160 NGWILPTVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYkyeDKNGKQPVGRFFGNTWAEMYRNrywkE 239
Cdd:cd19080  168 RGWSPFVALQIEYSLLERTPERELLPMARALGLGVTPWSPLGGGLLTGKY---QRGEEGRAGEAKGVTVGFGKLT----E 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 767903246 240 HHFEgIALVEKALQAAYGASAPSMTSATLR 269
Cdd:cd19080  241 RNWA-IVDVVAAVAEELGRSAAQVALAWVR 269
AKR_AKR9C1 cd19081
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ...
 13-275 2.63e-45

AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).


Pssm-ID: 381307 [Multi-domain]  Cd Length: 308  Bit Score: 157.76  E-value: 2.63e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  13 VLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYS-------EGQSETILGGLGLRLGGSDcRVKIDTK-AIPLFGN 84
Cdd:cd19081   13 CLGTMVFGWTADEETSFALLDAFVDAGGNFIDTADVYSawvpgnaGGESETIIGRWLKSRGKRD-RVVIATKvGFPMGPN 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  85 S--LKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGW 162
Cdd:cd19081   92 GpgLSRKHIRRAVEASLRRLQTDYIDLYQAHWDDPATPLEETLGALNDLIRQGKVRYIGASNYSAWRLQEALELSRQHGL 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 163 ILPTVYQGMYNAITRQ-VETELFPCLRHFGLRFYAFNPLAGGLLTGKYKYEDKNGKqpvgrffgNTWAEMYRNRYWKEHH 241
Cdd:cd19081  172 PRYVSLQPEYNLVDREsFEGELLPLCREEGIGVIPYSPLAGGFLTGKYRSEADLPG--------STRRGEAAKRYLNERG 243

                        250       260       270
                 ....*....|....*....|....*....|....
gi 767903246 242 FEGIALVEkALQAAYGAsapSMTSATLRWMYHHS 275
Cdd:cd19081  244 LRILDALD-EVAAEHGA---TPAQVALAWLLARP 273
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
 13-275 2.53e-42

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 149.38  E-value: 2.53e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246   13 VLGAMEMG---RRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKAIPLFGN---SL 86
Cdd:pfam00248   2 GLGTWQLGggwGPISKEEALEALRAALEAGINFIDTAEVYGDGKSEELLGEALKDYPVKRDKVVIATKVPDGDGPwpsGG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246   87 KPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEIctlcKSNGWILPT 166
Cdd:pfam00248  82 SKENIRKSLEESLKRLGTDYIDLYYLHWPDPDTPIEETWDALEELKKEGKIRAIGVSNFDAEQIEKA----LTKGKIPIV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  167 VYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYKYEDKNGKQPVGRFFGNTWAEMYrnrywkehhfEGIA 246
Cdd:pfam00248 158 AVQVEYNLLRRRQEEELLEYCKKNGIPLIAYSPLGGGLLTGKYTRDPDKGPGERRRLLKKGTPLNL----------EALE 227

                         250       260
                  ....*....|....*....|....*....
gi 767903246  247 LVEKaLQAAYGAsapSMTSATLRWMYHHS 275
Cdd:pfam00248 228 ALEE-IAKEHGV---SPAQVALRWALSKP 252
AKR_AKR11B1-like cd19084
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ...
 14-275 5.81e-40

AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.


Pssm-ID: 381310 [Multi-domain]  Cd Length: 296  Bit Score: 143.44  E-value: 5.81e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  14 LGAMEMGRRM-----DAPTSAAVTRAfLERGHTEIDTAFVYSEGQSETILGGLGlrlggSDCR--VKIDTK------AIP 80
Cdd:cd19084    9 LGTWAIGGTWwgevdDQESIEAIKAA-IDLGINFFDTAPVYGFGHSEEILGKAL-----KGRRddVVIATKcglrwdGGK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  81 LFGNSLKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKsn 160
Cdd:cd19084   83 GVTKDLSPESIRKEVEQSLRRLQTDYIDLYQIHWPDPNTPIEETAEALEKLKKEGKIRYIGVSNFSVEQLEEARKYGP-- 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 161 gwilPTVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYKyedkngkqPVGRFFGNTWaeMYRNRYWKEH 240
Cdd:cd19084  161 ----IVSLQPPYSMLEREIEEELLPYCRENGIGVLPYGPLAQGLLTGKYK--------KEPTFPPDDR--RSRFPFFRGE 226

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 767903246 241 HFE-GIALVE--KALQAAYGasaPSMTSATLRWMYHHS 275
Cdd:cd19084  227 NFEkNLEIVDklKEIAEKYG---KSLAQLAIAWTLAQP 261
AKR_PsAKR cd19091
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ...
 10-230 3.11e-36

Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.


Pssm-ID: 381317 [Multi-domain]  Cd Length: 319  Bit Score: 133.89  E-value: 3.11e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  10 PATVLGAMEMGRR---------MDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRlggSDCRVKIDTKAIP 80
Cdd:cd19091   14 SELALGTMTFGGGggffgawggVDQEEADRLVDIALDAGINFFDTADVYSEGESEEILGKALKG---RRDDVLIATKVRG 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  81 LFGNSLKPDSL-RFQL----ETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICT 155
Cdd:cd19091   91 RMGEGPNDVGLsRHHIiravEASLKRLGTDYIDLYQLHGFDALTPLEETLRALDDLVRQGKVRYIGVSNFSAWQIMKALG 170

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767903246 156 LCKSNGWILPTVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYKyedKNGKQPVGRFFGNTWAE 230
Cdd:cd19091  171 ISERRGLARFVALQAYYSLLGRDLEHELMPLALDQGVGLLVWSPLAGGLLSGKYR---RGQPAPEGSRLRRTGFD 242
AKR_EcYajO-like cd19079
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ...
 14-274 6.17e-36

Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.


Pssm-ID: 381305 [Multi-domain]  Cd Length: 312  Bit Score: 133.09  E-value: 6.17e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  14 LGAMEMGRR------MDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDcRVKIDTKaiplFGNSLK 87
Cdd:cd19079   17 LGCMSFGDPkwrpwvLDEEESRPIIKRALDLGINFFDTANVYSGGASEEILGRALKEFAPRD-EVVIATK----VYFPMG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  88 PDS---------LRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCK 158
Cdd:cd19079   92 DGPngrglsrkhIMAEVDASLKRLGTDYIDLYQIHRWDYETPIEETLEALHDVVKSGKVRYIGASSMYAWQFAKALHLAE 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 159 SNGWILPTVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYKYEDKNGKQPvgrffgnTWAEMYRNRYWK 238
Cdd:cd19079  172 KNGWTKFVSMQNHYNLLYREEEREMIPLCEEEGIGVIPWSPLARGRLARPWGDTTERRRST-------TDTAKLKYDYFT 244

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 767903246 239 EHHFEGIALVEKaLQAAYGAsapSMTSATLRWMYHH 274
Cdd:cd19079  245 EADKEIVDRVEE-VAKERGV---SMAQVALAWLLSK 276
Aldo_ket_red_shaker-like cd19074
Shaker potassium channel beta subunit family and similar proteins; This family includes ...
 20-261 1.35e-33

Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.


Pssm-ID: 381300 [Multi-domain]  Cd Length: 297  Bit Score: 126.55  E-value: 1.35e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  20 GRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSD----CRVKIDTKAIPL-FGNSLKpdSLRFQ 94
Cdd:cd19074   16 GGQVDDEDAKACVRKAYDLGINFFDTADVYAAGQAEEVLGKALKGWPRESyvisTKVFWPTGPGPNdRGLSRK--HIFES 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  95 LETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNA 174
Cdd:cd19074   94 IHASLKRLQLDYVDIYYCHRYDPETPLEETVRAMDDLIRQGKILYWGTSEWSAEQIAEAHDLARQFGLIPPVVEQPQYNM 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 175 ITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYkyedKNGKQPVGRFFGNTWaemyRNRYWKEHHF--EGIALVE--K 250
Cdd:cd19074  174 LWREIEEEVIPLCEKNGIGLVVWSPLAQGLLTGKY----RDGIPPPSRSRATDE----DNRDKKRRLLtdENLEKVKklK 245

                        250
                 ....*....|.
gi 767903246 251 ALQAAYGASAP 261
Cdd:cd19074  246 PIADELGLTLA 256
AKR_AKR11A1_11D1 cd19083
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ...
 23-230 2.31e-33

AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).


Pssm-ID: 381309 [Multi-domain]  Cd Length: 307  Bit Score: 125.99  E-value: 2.31e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  23 MDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDcrVKIDTKAIPLFG-------NSlkPDSLRFQL 95
Cdd:cd19083   30 LDEEEGKDLVREALDNGVNLLDTAFIYGLGRSEELVGEVLKEYNRNE--VVIATKGAHKFGgdgsvlnNS--PEFLRSAV 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  96 ETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEictlckSNGWILPTVYQGMYNAI 175
Cdd:cd19083  106 EKSLKRLNTDYIDLYYIHFPDGETPKAEAVGALQELKDEGKIRAIGVSNFSLEQLKE------ANKDGYVDVLQGEYNLL 179

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767903246 176 TRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKY----KYEDKNGKQPVGRFFGNTWAE 230
Cdd:cd19083  180 QREAEEDILPYCVENNISFIPYFPLASGLLAGKYtkdtKFPDNDLRNDKPLFKGERFSE 238
AKR_AKR14A1_2 cd19089
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ...
 83-228 4.20e-31

AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.


Pssm-ID: 381315 [Multi-domain]  Cd Length: 308  Bit Score: 120.05  E-value: 4.20e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  83 GNSLKpdSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGw 162
Cdd:cd19089   96 GGSRK--YLLASLDQSLKRMGLDYVDIFYHHRYDPDTPLEETMTALADAVRSGKALYVGISNYPGAKARRAIALLRELG- 172

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767903246 163 ILPTVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYkyedKNGKQPVGRFFGNTW 228
Cdd:cd19089  173 VPLIIHQPRYSLLDRWAEDGLLEVLEEAGIGFIAFSPLAQGLLTDKY----LNGIPPDSRRAAESK 234
AKR_AKR11B3 cd19085
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ...
 28-274 6.29e-31

Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.


Pssm-ID: 381311 [Multi-domain]  Cd Length: 292  Bit Score: 119.23  E-value: 6.29e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  28 SAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGlrlggSDCR--VKIDTKAiplFGNSLKPDSLRFQLETSLKRLQCP 105
Cdd:cd19085   25 SIATIHAALDAGINFFDTAEAYGDGHSEEVLGKAL-----KGRRddVVIATKV---SPDNLTPEDVRKSCERSLKRLGTD 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 106 RVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKsngwilPTVYQGMYNAITRQVETELFP 185
Cdd:cd19085   97 YIDLYQIHWPSSDVPLEETMEALEKLKEEGKIRAIGVSNFGPAQLEEALDAGR------IDSNQLPYNLLWRAIEYEILP 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 186 CLRHFGLRFYAFNPLAGGLLTGKYKYEDKNgkqPVGR--------FFGNTWAEMyrnrywkehhFEGIALVeKALQAAYG 257
Cdd:cd19085  171 FCREHGIGVLAYSPLAQGLLTGKFSSAEDF---PPGDartrlfrhFEPGAEEET----------FEALEKL-KEIADELG 236

                        250
                 ....*....|....*..
gi 767903246 258 AsapSMTSATLRWMYHH 274
Cdd:cd19085  237 V---TMAQLALAWVLQQ 250
AKR_unchar cd19102
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 28-270 3.37e-29

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381328 [Multi-domain]  Cd Length: 302  Bit Score: 114.69  E-value: 3.37e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  28 SAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGsdcRVKIDTKAIPLF------GNSLKPDSLRFQLETSLKR 101
Cdd:cd19102   28 SIAAIRAALDLGINWIDTAAVYGLGHSEEVVGRALKGLRD---RPIVATKCGLLWdeegriRRSLKPASIRAECEASLRR 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 102 LQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTlcksngwILP-TVYQGMYNAITRQVE 180
Cdd:cd19102  105 LGVDVIDLYQIHWPDPDEPIEEAWGALAELKEEGKVRAIGVSNFSVDQMKRCQA-------IHPiASLQPPYSLLRRGIE 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 181 TELFPCLRHFGLRFYAFNPLAGGLLTGKYkyedknGKQPVGRFFGNTWAEmyRNRYWKEHHF-EGIALVE--KALQAAYG 257
Cdd:cd19102  178 AEILPFCAEHGIGVIVYSPMQSGLLTGKM------TPERVASLPADDWRR--RSPFFQEPNLaRNLALVDalRPIAERHG 249

                        250
                 ....*....|....
gi 767903246 258 ASAPSMTSA-TLRW 270
Cdd:cd19102  250 RTVAQLAIAwVLRR 263
AKR_AKR13A_13D cd19076
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ...
 14-255 9.42e-29

AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.


Pssm-ID: 381302 [Multi-domain]  Cd Length: 303  Bit Score: 113.46  E-value: 9.42e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  14 LGAMEM---GRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGsdcRVKIDTK-------AIPLFG 83
Cdd:cd19076   17 LGCMGMsafYGPADEEESIATLHRALELGVTFLDTADMYGPGTNEELLGKALKDRRD---EVVIATKfgivrdpGSGFRG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  84 NSLKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYA------AWEVAEIctlc 157
Cdd:cd19076   94 VDGRPEYVRAACEASLKRLGTDVIDLYYQHRVDPNVPIEETVGAMAELVEEGKVRYIGLSEASadtirrAHAVHPI---- 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 158 ksngwilpTVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYKYEDKNGKQPVGRFFGntwaemyrnRYW 237
Cdd:cd19076  170 --------TAVQSEYSLWTRDIEDEVLPTCRELGIGFVAYSPLGRGFLTGAIKSPEDLPEDDFRRNNP---------RFQ 232

                        250
                 ....*....|....*...
gi 767903246 238 KEHHFEGIALVEKALQAA 255
Cdd:cd19076  233 GENFDKNLKLVEKLEAIA 250
AKR_AKR9A3_9B1-4 cd19147
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; ...
 13-227 3.36e-27

Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; Phanerochaete chrysosporium ADD (EC1.1.1.91) is a founding member of aldo-keto reductase family 9 member A3. It is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). This family also includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.


Pssm-ID: 381373 [Multi-domain]  Cd Length: 319  Bit Score: 109.53  E-value: 3.36e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  13 VLGAMEMG-------RRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDcRVKIDTK-------- 77
Cdd:cd19147   14 ILGAMSIGdawsgfmGSMDKEQAFELLDAFYEAGGNFIDTANNYQDEQSETWIGEWMKSRKNRD-QIVIATKfttdykay 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  78 ------AIPLFGNSLKpdSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVA 151
Cdd:cd19147   93 evgkgkAVNYCGNHKR--SLHVSVRDSLRKLQTDWIDILYVHWWDYTTSIEEVMDSLHILVQQGKVLYLGVSDTPAWVVS 170

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767903246 152 EICTLCKSNGWILPTVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYKYED--KNGkQPVGRFFGNT 227
Cdd:cd19147  171 AANYYATAHGKTPFSVYQGRWNVLNRDFERDIIPMARHFGMALAPWDVLGGGKFQSKKAVEErkKNG-EGLRSFVGGT 247
AKR_AKR3F1-like cd19072
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ...
 10-220 2.04e-26

Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381298 [Multi-domain]  Cd Length: 263  Bit Score: 106.16  E-value: 2.04e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  10 PATVLGAMEMGRRMDAPTS-----AAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDcrVKIDTKAIPlfgN 84
Cdd:cd19072    5 PVLGLGTWGIGGGMSKDYSddkkaIEALRYAIELGINLIDTAEMYGGGHAEELVGKAIKGFDRED--LFITTKVSP---D 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  85 SLKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGwil 164
Cdd:cd19072   80 HLKYDDVIKAAKESLKRLGTDYIDLYLIHWPNPSIPIEETLRAMEELVEEGKIRYIGVSNFSLEELEEAQSYLKKGP--- 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767903246 165 PTVYQGMYNAITRQVETELFP-CLRHfGLRFYAFNPLAGGLLTGKYKYE------DKNGKQPV 220
Cdd:cd19072  157 IVANQVEYNLFDREEESGLLPyCQKN-GIAIIAYSPLEKGKLSNAKGSPlldeiaKKYGKTPA 218
AKR_unchar cd19752
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 10-206 2.40e-26

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381391 [Multi-domain]  Cd Length: 291  Bit Score: 106.65  E-value: 2.40e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  10 PATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYSE-------GQSETILGGLGLRLGGSDcRVKIDTKA---- 78
Cdd:cd19752    1 SELCLGTMYFGTRTDEETSFAILDRYVAAGGNFLDTANNYAFwteggvgGESERLIGRWLKDRGNRD-DVVIATKVgagp 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  79 -IPLFGN----SLKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEI 153
Cdd:cd19752   80 rDPDGGPespeGLSAETIEQEIDKSLRRLGTDYIDLYYAHVDDRDTPLEETLEAFNELVKAGKVRAIGASNFAAWRLERA 159

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767903246 154 CTLCKSNGWILPTVYQ----------GMYNAITRQVETELFPCLR-HFGLRFYAFNPLAGGLLT 206
Cdd:cd19752  160 RQIARQQGWAEFSAIQqrhsylrprpGADFGVQRIVTDELLDYASsRPDLTLLAYSPLLSGAYT 223
AKR_AKR11B1 cd19148
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ...
 14-214 3.03e-26

Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381374 [Multi-domain]  Cd Length: 302  Bit Score: 106.62  E-value: 3.03e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  14 LGAMEMGRRM----DAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDcRVKIDTKAI-------PLF 82
Cdd:cd19148    9 LGTWAIGGWMwggtDEKEAIETIHKALDLGINLIDTAPVYGFGLSEEIVGKALKEYGKRD-RVVIATKVGlewdeggEVV 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  83 GNSlKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAaweVAEICTLCKsnGW 162
Cdd:cd19148   88 RNS-SPARIRKEVEDSLRRLQTDYIDLYQVHWPDPLVPIEETAEALKELLDEGKIRAIGVSNFS---PEQMETFRK--VA 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767903246 163 ILPTVyQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYKYEDK 214
Cdd:cd19148  162 PLHTV-QPPYNLFEREIEKDVLPYARKHNIVTLAYGALCRGLLSGKMTKDTK 212
AKR_AKR6C1_2 cd19143
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ...
 20-209 6.03e-26

AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.


Pssm-ID: 381369 [Multi-domain]  Cd Length: 319  Bit Score: 106.14  E-value: 6.03e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  20 GRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKAipLFGNSLKPDS--------L 91
Cdd:cd19143   25 GNQVDVDEAKECMKAAYDAGVNFFDNAEVYANGQSEEIMGQAIKELGWPRSDYVVSTKI--FWGGGGPPPNdrglsrkhI 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  92 RFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGM 171
Cdd:cd19143  103 VEGTKASLKRLQLDYVDLVFCHRPDPATPIEETVRAMNDLIDQGKAFYWGTSEWSAQQIEEAHEIADRLGLIPPVMEQPQ 182

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 767903246 172 YNAITRQ-VETELFPCLRHFGLRFYAFNPLAGGLLTGKY 209
Cdd:cd19143  183 YNLFHRErVEVEYAPLYEKYGLGTTTWSPLASGLLTGKY 221
AKR_AKR9A1-2 cd19146
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus ...
 3-225 7.67e-26

Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and similar proteins; Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV and Aspergillus flavus norsolorinic acid reductase (NOR), are founding members of aldo-keto reductase family 9 member A1-2 (AKR9A1-2), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis.


Pssm-ID: 381372 [Multi-domain]  Cd Length: 326  Bit Score: 105.97  E-value: 7.67e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246   3 RQLS-----RARPaTVLGAMEMGRR-------MDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDC 70
Cdd:cd19146    1 RQLSptagvRVSP-LCLGAMSFGEAwksmmgeCDKETAFKLLDAFYEQGGNFIDTANNYQGEESERWVGEWMASRGNRDE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  71 RVkIDTKAIPLF-------------GNSLKpdSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKF 137
Cdd:cd19146   80 MV-LATKYTTGYrrggpikiksnyqGNHAK--SLRLSVEASLKKLQTSYIDILYVHWWDYTTSIPELMQSLNHLVAAGKV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 138 VELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAggllTGKYKY-EDKNG 216
Cdd:cd19146  157 LYLGVSDTPAWVVSKANAYARAHGLTQFVVYQGHWSAAFRDFERDILPMCEAEGMALAPWGVLG----QGQFRTeEEFKR 232


                 ....*....
gi 767903246 217 KQPVGRFFG 225
Cdd:cd19146  233 RGRSGRKGG 241
AKR_AKR13C1_2 cd19078
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ...
 14-223 2.23e-25

AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.


Pssm-ID: 381304 [Multi-domain]  Cd Length: 301  Bit Score: 104.24  E-value: 2.23e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  14 LGAMEM----GRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGsdcRVKIDTK---------AIP 80
Cdd:cd19078    9 LGCMGMshgyGPPPDKEEMIELIRKAVELGITFFDTAEVYGPYTNEELVGEALKPFRD---QVVIATKfgfkidggkPGP 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  81 LFGNSlKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSnyaawEVAEiCTLCKSN 160
Cdd:cd19078   86 LGLDS-RPEHIRKAVEGSLKRLQTDYIDLYYQHRVDPNVPIEEVAGTMKELIKEGKIRHWGLS-----EAGV-ETIRRAH 158

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767903246 161 GwILP-TVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKY----KYEDKNGKQPVGRF 223
Cdd:cd19078  159 A-VCPvTAVQSEYSMMWREPEKEVLPTLEELGIGFVPFSPLGKGFLTGKIdentKFDEGDDRASLPRF 225
AKR_Tas-like cd19094
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ...
 95-266 4.03e-25

Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.


Pssm-ID: 381320 [Multi-domain]  Cd Length: 328  Bit Score: 104.18  E-value: 4.03e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  95 LETSLKRLQCPRVDLFYLHMPDH------------------STPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTL 156
Cdd:cd19094  102 VEGSLKRLGTDYIDLYQLHWPDRytplfgggyytepseeedSVSFEEQLEALGELVKAGKIRHIGLSNETPWGVMKFLEL 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 157 CKSNGWILPTVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYKyeDKNGKQPVGRF---------FGNT 227
Cdd:cd19094  182 AEQLGLPRIVSIQNPYSLLNRNFEEGLAEACHRENVGLLAYSPLAGGVLTGKYL--DGAARPEGGRLnlfpgymarYRSP 259

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 767903246 228 WAEMYRNRYWKEHHFEGIALVEKALqaAYGASAPSMTSA 266
Cdd:cd19094  260 QALEAVAEYVKLARKHGLSPAQLAL--AWVRSRPFVTST 296
AKR_AKR11B2 cd19149
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ...
 10-270 6.04e-25

Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.


Pssm-ID: 381375 [Multi-domain]  Cd Length: 315  Bit Score: 103.12  E-value: 6.04e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  10 PATVLGAMEMG-----RRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGsdcRVKIDTK------- 77
Cdd:cd19149   12 SVIGLGTWAIGggpwwGGSDDNESIRTIHAALDLGINLIDTAPAYGFGHSEEIVGKAIKGRRD---KVVLATKcglrwdr 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  78 ----------AIPLFGNsLKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAA 147
Cdd:cd19149   89 eggsfffvrdGVTVYKN-LSPESIREEVEQSLKRLGTDYIDLYQTHWQDVETPIEETMEALEELKRQGKIRAIGASNVSV 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 148 WEVAEICtlckSNGWIlpTVYQGMYNAITRQVETELFP-CLRHfGLRFYAFNPLAGGLLTGKYKyedkngkqPVGRFFGN 226
Cdd:cd19149  168 EQIKEYV----KAGQL--DIIQEKYSMLDRGIEKELLPyCKKN-NIAFQAYSPLEQGLLTGKIT--------PDREFDAG 232

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 767903246 227 TWaeMYRNRYWKEHHFEGI-ALVE--KALQAAYGAsapSMTSATLRW 270
Cdd:cd19149  233 DA--RSGIPWFSPENREKVlALLEkwKPLCEKYGC---TLAQLVIAW 274
AKR_AKR10A1_2 cd19082
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ...
 13-286 6.85e-25

AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.


Pssm-ID: 381308 [Multi-domain]  Cd Length: 291  Bit Score: 102.63  E-value: 6.85e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  13 VLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYS----EGQSETILGGLGLRLGGSDcRVKIDTK-AIPLFGNS-- 85
Cdd:cd19082    4 VLGTADFGTRIDEEEAFALLDAFVELGGNFIDTARVYGdwveRGASERVIGEWLKSRGNRD-KVVIATKgGHPDLEDMsr 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  86 --LKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNyaaWEVAEIC---TLCKSN 160
Cdd:cd19082   83 srLSPEDIRADLEESLERLGTDYIDLYFLHRDDPSVPVGEIVDTLNELVRAGKIRAFGASN---WSTERIAeanAYAKAH 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 161 GWILPTVYQGMYNAITRQVETELFPCL-------RHF----GLRFYAFNPLAGGLLTGKYKYEDkngkqpvgrffgnTWA 229
Cdd:cd19082  160 GLPGFAASSPQWSLARPNEPPWPGPTLvamdeemRAWheenQLPVFAYSSQARGFFSKRAAGGA-------------EDD 226

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767903246 230 EMYRNRYWKEHHFEGIALVeKALQAAYGASApsmTSATLRWMYHhsqlqvqNSMPTV 286
Cdd:cd19082  227 SELRRVYYSEENFERLERA-KELAEEKGVSP---TQIALAYVLN-------QPFPTV 272
AKR_AKR13B1 cd19088
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ...
 14-206 1.88e-21

AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.


Pssm-ID: 381314 [Multi-domain]  Cd Length: 256  Bit Score: 92.28  E-value: 1.88e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  14 LGAM------EMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRlggSDCRVKIDTK--AIPLFGNS 85
Cdd:cd19088    6 YGAMrltgpgIWGPPADREEAIAVLRRALELGVNFIDTADSYGPDVNERLIAEALHP---YPDDVVIATKggLVRTGPGW 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  86 LKPD----SLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNY------AAWEVAEICT 155
Cdd:cd19088   83 WGPDgspeYLRQAVEASLRRLGLDRIDLYQLHRIDPKVPFEEQLGALAELQDEGLIRHIGLSNVtvaqieEARAIVRIVS 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767903246 156 LcksngwilptvyQGMYNAITRQVETELFPCLRHfGLRFYAFNPLAGGLLT 206
Cdd:cd19088  163 V------------QNRYNLANRDDEGVLDYCEAA-GIAFIPWFPLGGGDLA 200
AKR_AKR14A2 cd19151
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is ...
 95-209 2.16e-21

Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).


Pssm-ID: 381377 [Multi-domain]  Cd Length: 309  Bit Score: 93.24  E-value: 2.16e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  95 LETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGwiLPT-VYQGMYN 173
Cdd:cd19151  107 LDQSLKRMGLDYVDIFYHHRPDPETPLEETMGALDQIVRQGKALYVGISNYPPEEAREAAAILKDLG--TPClIHQPKYS 184

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767903246 174 AITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKY 209
Cdd:cd19151  185 MFNRWVEEGLLDVLEEEGIGCIAFSPLAQGLLTDRY 220
AKR_AtPLR-like cd19093
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ...
 20-270 4.11e-20

Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.


Pssm-ID: 381319 [Multi-domain]  Cd Length: 293  Bit Score: 89.21  E-value: 4.11e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  20 GRRMDAPTSAAVTRAfLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDcRVKIDTKAIPLFgNSLKPDSLRFQLETSL 99
Cdd:cd19093   21 GEYGDEDLQAAFDAA-LEAGVNLFDTAEVYGTGRSERLLGRFLKELGDRD-EVVIATKFAPLP-WRLTRRSVVKALKASL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 100 KRLQCPRVDLFYLHMPDH-STPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGwILPTVYQGMYNAITRQ 178
Cdd:cd19093   98 ERLGLDSIDLYQLHWPGPwYSQIEALMDGLADAVEEGLVRAVGVSNYSADQLRRAHKALKERG-VPLASNQVEYSLLYRD 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 179 VET-ELFPCLRHFGLRFYAFNPLAGGLLTGKYKYEDKNGKQPVGRFFGNTWAEMYrnrywkehhfegiALVE--KALQAA 255
Cdd:cd19093  177 PEQnGLLPACDELGITLIAYSPLAQGLLTGKYSPENPPPGGRRRLFGRKNLEKVQ-------------PLLDalEEIAEK 243

                        250
                 ....*....|....*
gi 767903246 256 YGAsapSMTSATLRW 270
Cdd:cd19093  244 YGK---TPAQVALNW 255
PRK09912 PRK09912
L-glyceraldehyde 3-phosphate reductase; Provisional
 95-209 7.02e-19

L-glyceraldehyde 3-phosphate reductase; Provisional


Pssm-ID: 182140 [Multi-domain]  Cd Length: 346  Bit Score: 86.58  E-value: 7.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  95 LETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSngWILP-TVYQGMYN 173
Cdd:PRK09912 120 LDQSLKRMGLEYVDIFYSHRVDENTPMEETASALAHAVQSGKALYVGISSYSPERTQKMVELLRE--WKIPlLIHQPSYN 197

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 767903246 174 AITRQVE-TELFPCLRHFGLRFYAFNPLAGGLLTGKY 209
Cdd:PRK09912 198 LLNRWVDkSGLLDTLQNNGVGCIAFTPLAQGLLTGKY 234
Aldo_ket_red_shaker cd19141
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family ...
 31-210 1.00e-17

Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.


Pssm-ID: 381367 [Multi-domain]  Cd Length: 310  Bit Score: 82.88  E-value: 1.00e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  31 VTRAFlERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKaipLF--GNSLKPDSLRFQ-----LETSLKRLQ 103
Cdd:cd19141   36 VTLAY-ENGINLFDTAEVYAAGKAEIVLGKILKKKGWRRSSYVITTK---IFwgGKAETERGLSRKhiiegLKASLERLQ 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 104 CPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNAITR-QVETE 182
Cdd:cd19141  112 LEYVDIVFANRPDPNTPMEEIVRAFTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNLIPPIVEQAEYHLFQReKVEMQ 191

                        170       180
                 ....*....|....*....|....*....
gi 767903246 183 LfPCLRH-FGLRFYAFNPLAGGLLTGKYK 210
Cdd:cd19141  192 L-PELFHkIGVGAMTWSPLACGILSGKYD 219
AKR_AKR15A-like cd19090
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ...
 14-253 1.58e-17

AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).


Pssm-ID: 381316 [Multi-domain]  Cd Length: 278  Bit Score: 81.83  E-value: 1.58e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  14 LGAMEMGRRMDAptSAAVTRAFLERGHTEIDTAFVYseGQSETILGGLGLRLGGSDCRV--KIDTKAIPLFGNSlkPDSL 91
Cdd:cd19090   10 LGGVFGGVDDDE--AVATIRAALDLGINYIDTAPAY--GDSEERLGLALAELPREPLVLstKVGRLPEDTADYS--ADRV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  92 RFQLETSLKRLQCPRVDLFYLHMPDHSTPVEET-----LRACHQLHQEGKFVELGLsnyAAWEVAEICTLCKSNGW--IL 164
Cdd:cd19090   84 RRSVEESLERLGRDRIDLLMIHDPERVPWVDILapggaLEALLELKEEGLIKHIGL---GGGPPDLLRRAIETGDFdvVL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 165 ptVYQGmYNAITRQVETELFP-CLRHfGLRFYAFNPLAGGLLTGKYKYEDKNGKQPVGRFFGNTWAEMYRnryWKEHHfe 243
Cdd:cd19090  161 --TANR-YTLLDQSAADELLPaAARH-GVGVINASPLGMGLLAGRPPERVRYTYRWLSPELLDRAKRLYE---LCDEH-- 231

                        250
                 ....*....|
gi 767903246 244 GIALVEKALQ 253
Cdd:cd19090  232 GVPLPALALR 241
AKR_AKR11C1 cd19086
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ...
 14-208 2.45e-17

AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.


Pssm-ID: 381312 [Multi-domain]  Cd Length: 238  Bit Score: 80.21  E-value: 2.45e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  14 LGAMEMGRRMDAPTS-----AAVTRAfLERGHTEIDTAFVYSEGQSETILGGLGlrlggSDCR--VKIDTKaiplFGNSL 86
Cdd:cd19086    8 FGTWGLGGDWWGDVDdaeaiRALRAA-LDLGINFFDTADVYGDGHSERLLGKAL-----KGRRdkVVIATK----FGNRF 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  87 K----------PDSLRFQLETSLKRLQCPRVDLFYLHMPDHS-TPVEETLRACHQLHQEGKFVELGLS---NYAAWEVAE 152
Cdd:cd19086   78 DggperpqdfsPEYIREAVEASLKRLGTDYIDLYQLHNPPDEvLDNDELFEALEKLKQEGKIRAYGVSvgdPEEALAALR 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767903246 153 ictlcksNGWIlpTVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGK 208
Cdd:cd19086  158 -------RGGI--DVVQVIYNLLDQRPEEELFPLAEEHGVGVIARVPLASGLLTGK 204
AKR_AKR13A1 cd19144
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ...
 2-213 1.54e-16

AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.


Pssm-ID: 381370 [Multi-domain]  Cd Length: 323  Bit Score: 79.41  E-value: 1.54e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246   2 SRQLSRARPA-TVLGAMEMG-------RRMDAPTSAAVTRAFlERGHTEIDTAFVYseGQSETILGGLGLRLGGSDCRVK 73
Cdd:cd19144    3 TRTLGRNGPSvPALGFGAMGlsafygpPKPDEERFAVLDAAF-ELGCTFWDTADIY--GDSEELIGRWFKQNPGKREKIF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  74 IDTKaiplFGNSL-----------KPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGL 142
Cdd:cd19144   80 LATK----FGIEKnvetgeysvdgSPEYVKKACETSLKRLGVDYIDLYYQHRVDGKTPIEKTVAAMAELVQEGKIKHIGL 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767903246 143 SNYAAWEVAEICTlcksngwILP-TVYQGMYNAITRQVET---ELFPCLRHFGLRFYAFNPLAGGLLTGKYKYED 213
Cdd:cd19144  156 SECSAETLRRAHA-------VHPiAAVQIEYSPFSLDIERpeiGVLDTCRELGVAIVAYSPLGRGFLTGAIRSPD 223
AKR_YeaE cd19138
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ...
 10-205 6.46e-16

Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381364 [Multi-domain]  Cd Length: 266  Bit Score: 76.90  E-value: 6.46e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  10 PATVLGAMEMG-RRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGlrlggSDCR--VKIDTKAIPlfGNSl 86
Cdd:cd19138   12 PALGQGTWYMGeDPAKRAQEIEALRAGIDLGMTLIDTAEMYGDGGSEELVGEAI-----RGRRdkVFLVSKVLP--SNA- 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  87 KPDSLRFQLETSLKRLQCPRVDLFYLHMPDhSTPVEETLRACHQLHQEGKFVELGLSNY------AAWEVAeictlcksn 160
Cdd:cd19138   84 SRQGTVRACERSLRRLGTDYLDLYLLHWRG-GVPLAETVAAMEELKKEGKIRAWGVSNFdtddmeELWAVP--------- 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 767903246 161 GWILPTVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLA-GGLL 205
Cdd:cd19138  154 GGGNCAANQVLYNLGSRGIEYDLLPWCREHGVPVMAYSPLAqGGLL 199
AKR_unchar cd19103
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 15-266 1.53e-15

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381329 [Multi-domain]  Cd Length: 299  Bit Score: 76.22  E-value: 1.53e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  15 GAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDcrVKIDTKAIPLfGNSLKPDSLRFQ 94
Cdd:cd19103   21 GDQVFGNHLDEDTLKAVFDKAMAAGLNLWDTAAVYGMGASEKILGEFLKRYPRED--YIISTKFTPQ-IAGQSADPVADM 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  95 LETSLKRLQCPRVDLFYLHMPdhsTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVyQGMYNA 174
Cdd:cd19103   98 LEGSLARLGTDYIDIYWIHNP---ADVERWTPELIPLLKSGKVKHVGVSNHNLAEIKRANEILAKAGVSLSAV-QNHYSL 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 175 ITRQVETE--LFPCLRHfGLRFYAFNPLAGGLLTGKYkyeDKNGKQPVGRFFGNTWaemyrNRYWKEhhFEGIALVEKAL 252
Cdd:cd19103  174 LYRSSEEAgiLDYCKEN-GITFFAYMVLEQGALSGKY---DTKHPLPEGSGRAETY-----NPLLPQ--LEELTAVMAEI 242

                        250
                 ....*....|....
gi 767903246 253 QAAYGASAPSMTSA 266
Cdd:cd19103  243 GAKHGASIAQVAIA 256
AKR_AKR3F2_3 cd19073
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ...
 29-145 1.88e-15

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381299 [Multi-domain]  Cd Length: 243  Bit Score: 75.00  E-value: 1.88e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  29 AAVTRAFLERGHTEIDTAFVYsEGQSETILGGLGLRLGGSDcrVKIDTKaipLFGNSLKPDSLRFQLETSLKRLQCPRVD 108
Cdd:cd19073   17 ANAVKEALELGYRHIDTAEIY-NNEAEVGEAIAESGVPRED--LFITTK---VWRDHLRPEDLKKSVDRSLEKLGTDYVD 90

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 767903246 109 LFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNY 145
Cdd:cd19073   91 LLLIHWPNPTVPLEETLGALKELKEAGKVKSIGVSNF 127
AKR_AKR13D1 cd19145
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ...
 14-213 2.54e-15

AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.


Pssm-ID: 381371 [Multi-domain]  Cd Length: 304  Bit Score: 75.55  E-value: 2.54e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  14 LGAMEMGRRMDAPTSA----AVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSdcRVKIDTK-AIPLFGNSLK- 87
Cdd:cd19145   17 LGCMGLSGDYGAPKPEeegiALIHHAFNSGVTFLDTSDIYGPNTNEVLLGKALKDGPRE--KVQLATKfGIHEIGGSGVe 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  88 ----PDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAwevaeiCTLCKSNGwI 163
Cdd:cd19145   95 vrgdPAYVRAACEASLKRLDVDYIDLYYQHRIDTTVPIEITMGELKKLVEEGKIKYIGLSEASA------DTIRRAHA-V 167

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767903246 164 LP-TVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYKYED 213
Cdd:cd19145  168 HPiTAVQLEWSLWTRDIEEEIIPTCRELGIGIVPYSPLGRGFFAGKAKLEE 218
AKR_AKR14A1 cd19150
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar ...
 95-209 4.16e-15

Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar proteins; Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.


Pssm-ID: 381376 [Multi-domain]  Cd Length: 309  Bit Score: 75.18  E-value: 4.16e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  95 LETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILpTVYQGMYNA 174
Cdd:cd19150  107 LDQSLKRMGLDYVDIFYSHRFDPDTPLEETMGALDHAVRSGKALYVGISSYSPERTREAAAILRELGTPL-LIHQPSYNM 185

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767903246 175 ITRQVE-TELFPCLRHFGLRFYAFNPLAGGLLTGKY 209
Cdd:cd19150  186 LNRWVEeSGLLDTLQELGVGCIAFTPLAQGLLTDKY 221
AKR_KCAB1B_AKR6A3-like cd19159
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo ...
 37-210 3.53e-14

voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo sapiens, Mus musculus, Mustela putorius, Rattus norvegicus, and Kvb1.1, Kvb1.2 from Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A3 (AKR6A3), A8 (AKR6A8), A10a (AKR6A10a), A13 (AKR6A13), A7 (AKR6A7) and A10b (AKR6A10b), respectively. KCAB1B, also called Shaker channel b-subunit 1(Kvb1), K(+) channel subunit beta-1, or Kv-beta-1, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It modulates action potentials via its effect on the pore-forming alpha subunits.


Pssm-ID: 381385 [Multi-domain]  Cd Length: 323  Bit Score: 72.77  E-value: 3.53e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  37 ERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKaipLF--GNSLKPDSLRFQ-----LETSLKRLQCPRVDL 109
Cdd:cd19159   42 ESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVITTK---LYwgGKAETERGLSRKhiiegLKGSLQRLQLEYVDV 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 110 FYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNAITRQ-VETELfPCLR 188
Cdd:cd19159  119 VFANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHLFQREkVEVQL-PELY 197

                        170       180
                 ....*....|....*....|...
gi 767903246 189 H-FGLRFYAFNPLAGGLLTGKYK 210
Cdd:cd19159  198 HkIGVGAMTWSPLACGIISGKYG 220
AKR_AKR3F1 cd19137
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ...
 33-205 1.26e-13

Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381363 [Multi-domain]  Cd Length: 260  Bit Score: 70.29  E-value: 1.26e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  33 RAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDcrVKIDTKAIPlfgNSLKPDSLRFQLETSLKRLQCPRVDLFYL 112
Cdd:cd19137   33 KTAIELGYTHIDTAEMYGGGHTEELVGKAIKDFPRED--LFIVTKVWP---TNLRYDDLLRSLQNSLRRLDTDYIDLYLI 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 113 HMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSngwilPTVY-QGMYNAITRQVETE-LFPCLRHF 190
Cdd:cd19137  108 HWPNPNIPLEETLSAMAEGVRQGLIRYIGVSNFNRRLLEEAISKSQT-----PIVCnQVKYNLEDRDPERDgLLEYCQKN 182

                        170
                 ....*....|....*
gi 767903246 191 GLRFYAFNPLAGGLL 205
Cdd:cd19137  183 GITVVAYSPLRRGLE 197
AKR_KCAB2B_AKR6A1-like cd19158
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos ...
 20-209 2.18e-13

voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos taurus, Rattus norvegicus, Mus musculus, Homo sapiens, and Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A1 (AKR6A1), A2 (AKR6A2), A4 (AKR6A4), A5 (AKR6A5), and A6 (AKR6A6), respectively. KCAB2B, also called Shaker channel b-subunit 2 (Kvb2), or K(+) channel subunit beta-2, or Kv-beta-2, or Kvbeta2, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It may be involved in the regulation of nerve signaling, and prevents neuronal hyperexcitability.


Pssm-ID: 381384 [Multi-domain]  Cd Length: 324  Bit Score: 70.11  E-value: 2.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  20 GRRMDAPTSAAVTRAFlERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKaIPLFGNSLKPDSLRFQ----- 94
Cdd:cd19158   26 GQITDEMAEHLMTLAY-DNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTK-IFWGGKAETERGLSRKhiieg 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  95 LETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNA 174
Cdd:cd19158  104 LKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQAEYHM 183

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 767903246 175 ITRQ-VETELFPCLRHFGLRFYAFNPLAGGLLTGKY 209
Cdd:cd19158  184 FQREkVEVQLPELFHKIGVGAMTWSPLACGIVSGKY 219
AKR_AKR1G1_1I cd19111
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ...
 28-158 4.17e-13

Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.


Pssm-ID: 381337 [Multi-domain]  Cd Length: 286  Bit Score: 69.06  E-value: 4.17e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  28 SAAVTRAfLERGHTEIDTAFVY-SEGQSETILGGLGLRLGGSDCRVKIDTKAIPLFgnsLKPDSLRFQLETSLKRLQCPR 106
Cdd:cd19111   20 RAAVDYA-LFVGYRHIDTALSYqNEKAIGEALKWWLKNGKLKREEVFITTKLPPVY---LEFKDTEKSLEKSLENLKLPY 95

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767903246 107 VDLFYLHMP-------------DHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCK 158
Cdd:cd19111   96 VDLYLIHHPcgfvnkkdkgereLASSDVTSVWRAMEALVSEGKVKSIGLSNFNPRQINKILAYAK 160
AKR_unchar cd19101
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 20-209 1.48e-12

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381327 [Multi-domain]  Cd Length: 304  Bit Score: 67.62  E-value: 1.48e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  20 GRRMDAPTSAAVT--RAFLERGHTEIDTAFVYseGQSETIL---GGLGLRLGGSDCRVKIDTKAIPlFGNSLKPDS--LR 92
Cdd:cd19101   15 GHGGIRDEDAAVRamAAYVDAGLTTFDCADIY--GPAEELIgefRKRLRRERDAADDVQIHTKWVP-DPGELTMTRayVE 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  93 FQLETSLKRLQCPRVDLFYLHMPDHSTP-VEETLRACHQLHQEGKFVELGLSNYAAWEVAEICtlckSNGwiLPTVY-QG 170
Cdd:cd19101   92 AAIDRSLKRLGVDRLDLVQFHWWDYSDPgYLDAAKHLAELQEEGKIRHLGLTNFDTERLREIL----DAG--VPIVSnQV 165

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 767903246 171 MYNAITRQVETELFP-CLRHfGLRFYAFNPLAGGLLTGKY 209
Cdd:cd19101  166 QYSLLDRRPENGMAAlCEDH-GIKLLAYGTLAGGLLSEKY 204
AKR_AKR1-5-like cd19071
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ...
 27-203 1.53e-12

AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.


Pssm-ID: 381297 [Multi-domain]  Cd Length: 251  Bit Score: 66.74  E-value: 1.53e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  27 TSAAVTRAfLERGHTEIDTAFVYS--EGQSETIlgglglrlggSDCRVK-----IDTKaipLFGNSLKPDSLRFQLETSL 99
Cdd:cd19071   16 TAEAVLAA-LEAGYRHIDTAAAYGneAEVGEAI----------RESGVPreelfITTK---LWPTDHGYERVREALEESL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 100 KRLQCPRVDLFYLHMP------DHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKsngwILPTVYQGMYN 173
Cdd:cd19071   82 KDLGLDYLDLYLIHWPvpgkegGSKEARLETWRALEELVDEGLVRSIGVSNFNVEHLEELLAAAR----IKPAVNQIELH 157

                        170       180       190
                 ....*....|....*....|....*....|
gi 767903246 174 AITRQVETELFpCLRHfGLRFYAFNPLAGG 203
Cdd:cd19071  158 PYLQQKELVEF-CKEH-GIVVQAYSPLGRG 185
tas PRK10625
putative aldo-keto reductase; Provisional
 14-221 3.70e-12

putative aldo-keto reductase; Provisional


Pssm-ID: 236727 [Multi-domain]  Cd Length: 346  Bit Score: 66.80  E-value: 3.70e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  14 LGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVY-------SEGQSETILGGLGLRLGGSDCRVKIDTKAIPLFGN-- 84
Cdd:PRK10625  18 LGTMTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYpvpprpeTQGLTETYIGNWLAKRGSREKLIIASKVSGPSRNNdk 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  85 SLKPD------SLRFQLETSLKRLQCPRVDLFYLHMPDH--------------STPVE---ETLRACHQLHQEGKFVELG 141
Cdd:PRK10625  98 GIRPNqaldrkNIREALHDSLKRLQTDYLDLYQVHWPQRptncfgklgyswtdSAPAVsllETLDALAEQQRAGKIRYIG 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 142 LSNYAAWEVAEICTLCKSNGwiLPTVY--QGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYkyedKNGKQP 219
Cdd:PRK10625 178 VSNETAFGVMRYLHLAEKHD--LPRIVtiQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCLAFGTLTGKY----LNGAKP 251


                 ..
gi 767903246 220 VG 221
Cdd:PRK10625 252 AG 253
AKR_KCAB3B_AKR6A9-like cd19160
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo ...
 24-209 5.55e-12

voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo sapiens, Rattus norvegicus, and Mus musculus, are founding members of aldo-keto reductase family 6 member A9 (AKR6A9), A12 (AKR6A12), A14 (AKR6A14), respectively. KCAB3B, also called Shaker channel b-subunit 3 (Kvb3), K(+) channel subunit beta-3, or Kv-beta-3, is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. It alters the functional properties of Kv1.5.


Pssm-ID: 381386 [Multi-domain]  Cd Length: 325  Bit Score: 66.16  E-value: 5.55e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  24 DAPTSAAVTRAFlERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKaIPLFGNSLKPDSLRFQ-----LETS 98
Cdd:cd19160   32 DETAEDLLTVAY-EHGVNLFDTAEVYAAGKAERTLGNILKSKGWRRSSYVVTTK-IYWGGQAETERGLSRKhiiegLRGS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  99 LKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNAITRQ 178
Cdd:cd19160  110 LDRLQLEYVDIVFANRSDPNSPMEEIVRAMTYVINQGMAMYWGTSRWSAMEIMEAYSVARQFNLIPPVCEQAEYHLFQRE 189

                        170       180       190
                 ....*....|....*....|....*....|...
gi 767903246 179 -VETELfPCLRH-FGLRFYAFNPLAGGLLTGKY 209
Cdd:cd19160  190 kVEMQL-PELYHkIGVGSVTWSPLACGLITGKY 221
AKR_unchar cd19105
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 14-143 7.16e-12

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381331 [Multi-domain]  Cd Length: 250  Bit Score: 64.91  E-value: 7.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  14 LGAMEMGRRmdaptSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDcrVKIDTKAIPLfGNSLKPDSLRF 93
Cdd:cd19105   18 FGGGGLPRE-----SPELLRRALDLGINYFDTAEGYGNGNSEEIIGEALKGLRRDK--VFLATKASPR-LDKKDKAELLK 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767903246  94 QLETSLKRLQCPRVDLFYLHMPDHSTP---VEETLRACHQLHQEGKFVELGLS 143
Cdd:cd19105   90 SVEESLKRLQTDYIDIYQLHGVDTPEErllNEELLEALEKLKKEGKVRFIGFS 142
AKR_BsYcsN_EcYdhF-like cd19092
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ...
 13-145 1.26e-11

Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.


Pssm-ID: 381318 [Multi-domain]  Cd Length: 287  Bit Score: 64.50  E-value: 1.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  13 VLGAMemgRRMDAPTSAAVTRAF----LERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKA-I----PLFG 83
Cdd:cd19092   10 VLGCM---RLADWGESAEELLSLieaaLELGITTFDHADIYGGGKCEELFGEALALNPGLREKIEIQTKCgIrlgdDPRP 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767903246  84 NSLK-----PDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNY 145
Cdd:cd19092   87 GRIKhydtsKEHILASVEGSLKRLGTDYLDLLLLHRPDPLMDPEEVAEAFDELVKSGKVRYFGVSNF 153
ARA1 COG0656
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...
 24-206 7.22e-11

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440421 [Multi-domain]  Cd Length: 259  Bit Score: 61.99  E-value: 7.22e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  24 DAPTSAAVTRAfLERGHTEIDTAFVYS--EGQSETILGglglrlggSDCR---VKIDTKaipLFGNSLKPDSLRFQLETS 98
Cdd:COG0656   17 GEEAAAAVRTA-LEAGYRHIDTAAMYGneEGVGEAIAA--------SGVPreeLFVTTK---VWNDNHGYDDTLAAFEES 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  99 LKRLQCPRVDLFYLHMPDHsTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKsngwILPTVYQGMYNAITRQ 178
Cdd:COG0656   85 LERLGLDYLDLYLIHWPGP-GPYVETWRALEELYEEGLIRAIGVSNFDPEHLEELLAETG----VKPAVNQVELHPYLQQ 159

                        170       180
                 ....*....|....*....|....*....
gi 767903246 179 veTELFPCLRHFGLRFYAFNPLA-GGLLT 206
Cdd:COG0656  160 --RELLAFCREHGIVVEAYSPLGrGKLLD 186
AKR_PA4992-like cd19095
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ...
 14-266 2.75e-10

Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381321 [Multi-domain]  Cd Length: 253  Bit Score: 60.33  E-value: 2.75e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  14 LGAMEMGR---RMDAPTSAAVTRAFLERGHTEIDTAFVYseGQSETILGGLGLRLGGSDcrVKIDTKAIPLFGNSLK--- 87
Cdd:cd19095    5 LGTSGIGRvwgVPSEAEAARLLNTALDLGINLIDTAPAY--GRSEERLGRALAGLRRDD--LFIATKVGTHGEGGRDrkd 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  88 --PDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAawevAEICTLCKSNgwiLP 165
Cdd:cd19095   81 fsPAAIRASIERSLRRLGTDYIDLLQLHGPSDDELTGEVLETLEDLKAAGKVRYIGVSGDG----EELEAAIASG---VF 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 166 TVYQGMYNAITRQVEtELFPCLRHFGLRFYAFNPLAGGLLtgkykyedkngkqpVGRFFGNTWAEMYRNRYWKEHHFEGI 245
Cdd:cd19095  154 DVVQLPYNVLDREEE-ELLPLAAEAGLGVIVNRPLANGRL--------------RRRVRRRPLYADYARRPEFAAEIGGA 218

                        250       260
                 ....*....|....*....|.
gi 767903246 246 ALVEKALQAAygASAPSMTSA 266
Cdd:cd19095  219 TWAQAALRFV--LSHPGVSSA 237
AKR_Fe-S_oxidoreductase cd19096
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ...
 14-205 4.53e-10

Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381322 [Multi-domain]  Cd Length: 255  Bit Score: 59.50  E-value: 4.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  14 LGAMEM----GRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSdcRVKIDTKaIPLFGNSlKPD 89
Cdd:cd19096    5 FGTMRLpesdDDSIDEEKAIEMIRYAIDAGINYFDTAYGYGGGKSEEILGEALKEGPRE--KFYLATK-LPPWSVK-SAE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  90 SLRFQLETSLKRLQCPRVDLFYLHMPDHSTpVEETLRACH------QLHQEGKFVELGLSNYAAWEVaeICTLCKSNGW- 162
Cdd:cd19096   81 DFRRILEESLKRLGVDYIDFYLLHGLNSPE-WLEKARKGGllefleKAKKEGLIRHIGFSFHDSPEL--LKEILDSYDFd 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 767903246 163 --ILPtvyqgmYNAItRQVETELFPCLRH---FGLRFYAFNPLAGGLL 205
Cdd:cd19096  158 fvQLQ------YNYL-DQENQAGRPGIEYaakKGMGVIIMEPLKGGGL 198
AKR_AKR3F3 cd19140
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ...
 21-145 3.43e-09

Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381366 [Multi-domain]  Cd Length: 253  Bit Score: 56.88  E-value: 3.43e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  21 RRMDAPTSAAVTRAFLERGHTEIDTAFVY-SEGQ-SETIlgglglrlggSDCRVKID-----TKAIPlfgNSLKPDSLRF 93
Cdd:cd19140   16 YPLTGEECTRAVEHALELGYRHIDTAQMYgNEAQvGEAI----------AASGVPRDelfltTKVWP---DNYSPDDFLA 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767903246  94 QLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNY 145
Cdd:cd19140   83 SVEESLRKLRTDYVDLLLLHWPNKDVPLAETLGALNEAQEAGLARHIGVSNF 134
COG1453 COG1453
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
14-206 4.32e-09

Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];


Pssm-ID: 441062 [Multi-domain]  Cd Length: 365  Bit Score: 57.52  E-value: 4.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  14 LGAMemgR--RMDAPTSAAVTRAFLERGHTEIDTAFVYseGQSETILGGLGlrlggSDCR--VKIDTKaIPLFGNSlkPD 89
Cdd:COG1453   18 FGGM---RlpRKDEEEAEALIRRAIDNGINYIDTARGY--GDSEEFLGKAL-----KGPRdkVILATK-LPPWVRD--PE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  90 SLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLR------ACHQLHQEGKFVELGLSNYAAWEVAEicTLCKSNGWi 163
Cdd:COG1453   85 DMRKDLEESLKRLQTDYIDLYLIHGLNTEEDLEKVLKpggaleALEKAKAEGKIRHIGFSTHGSLEVIK--EAIDTGDF- 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 767903246 164 lpTVYQGMYNAI--TRQVETELFPCLRHFGLRFYAFNPLAGGLLT 206
Cdd:COG1453  162 --DFVQLQYNYLdqDNQAGEEALEAAAEKGIGVIIMKPLKGGRLA 204
AKR_unchar cd19099
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 33-149 5.47e-09

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381325 [Multi-domain]  Cd Length: 316  Bit Score: 56.94  E-value: 5.47e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  33 RAFLERGHTEIDTAFVYSEGQSETI----------------------------------LGGLGLRLGGSDCRVKIDTKA 78
Cdd:cd19099   28 KAALDSGINVIDTAINYRGGRSERLigkalreliekggikrdevvivtkagyipgdgdePLRPLKYLEEKLGRGLIDVAD 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  79 IPLFGNSLKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPV----------EETLRACHQLHQEGKfvelgLSNY--A 146
Cdd:cd19099  108 SAGLRHCISPAYLEDQIERSLKRLGLDTIDLYLLHNPEEQLLElgeeefydrlEEAFEALEEAVAEGK-----IRYYgiS 182


                 ...
gi 767903246 147 AWE 149
Cdd:cd19099  183 TWD 185
AKR_AKR5C2 cd19131
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ...
 24-219 2.49e-08

Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.


Pssm-ID: 381357 [Multi-domain]  Cd Length: 256  Bit Score: 54.30  E-value: 2.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  24 DAPTSAAVTRAfLERGHTEIDTAFVY--SEGQSETILGGLGLRLggsdcRVKIDTKaipLFGNSLKPDSLRFQLETSLKR 101
Cdd:cd19131   22 NDEAASAVREA-LEVGYRSIDTAAIYgnEEGVGKAIRASGVPRE-----ELFITTK---LWNSDQGYDSTLRAFDESLRK 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 102 LQCPRVDLFYLHMPdhsTPVE----ETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKsngwILPTVYQGMYNAITR 177
Cdd:cd19131   93 LGLDYVDLYLIHWP---VPAQdkyvETWKALIELKKEGRVKSIGVSNFTIEHLQRLIDETG----VVPVVNQIELHPRFQ 165

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 767903246 178 QVETELFpCLRHfGLRFYAFNPLA-GGLLTGKY--KYEDKNGKQP 219
Cdd:cd19131  166 QRELRAF-HAKH-GIQTESWSPLGqGGLLSDPVigEIAEKHGKTP 208
AKR_AKR6B1 cd19142
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ...
 95-208 5.83e-08

AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.


Pssm-ID: 381368 [Multi-domain]  Cd Length: 325  Bit Score: 53.62  E-value: 5.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  95 LETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNA 174
Cdd:cd19142  103 VRASLRRLQLDYIDIVIIHKADPMCPMEEVVRAMSYLIDNGLIMYWGTSRWSPVEIMEAFSIARQFNCPTPICEQSEYHM 182

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 767903246 175 ITRQ-VETELFPCLRHFGLRFYAFNPLAGGLLTGK 208
Cdd:cd19142  183 FCREkMELYMPELYNKVGVGLITWSPLSLGLDPGI 217
AKR_unchar cd19100
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 14-208 6.00e-08

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381326 [Multi-domain]  Cd Length: 238  Bit Score: 52.87  E-value: 6.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  14 LGAMEMGRrMDAPTSAAVTRAFLERGHTEIDTAFVYseGQSEtilgglglrlggsdcrvkidtkaiPLFGNSLKP----- 88
Cdd:cd19100   16 FGGGPLGR-LSQEEAAAIIRRALDLGINYFDTAPSY--GDSE------------------------EKIGKALKGrrdkv 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  89 -----------DSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEET------LRACHQLHQEGKFVELGLS---NYAAW 148
Cdd:cd19100   69 flatktgardyEGAKRDLERSLKRLGTDYIDLYQLHAVDTEEDLDQVfgpggaLEALLEAKEEGKIRFIGISghsPEVLL 148

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767903246 149 EVAEictlcksNGWIlPTVyQGMYNAITRQV---ETELFP-CLRHfGLRFYAFNPLAGGLLTGK 208
Cdd:cd19100  149 RALE-------TGEF-DVV-LFPINPAGDHIdsfREELLPlAREK-GVGVIAMKVLAGGRLLSG 202
AKR_CeZK1290-like cd19135
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ...
 89-205 1.51e-07

Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.


Pssm-ID: 381361 [Multi-domain]  Cd Length: 265  Bit Score: 51.94  E-value: 1.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  89 DSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPV-------EETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKsng 161
Cdd:cd19135   83 ESTKQAFEASLKRLGVDYLDLYLLHWPDCPSSGknvketrAETWRALEELYDEGLCRAIGVSNFLIEHLEQLLEDCS--- 159

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 767903246 162 wILPTVYQGMYNAITRQVetELFPCLRHFGLRFYAFNPLAGGLL 205
Cdd:cd19135  160 -VVPHVNQVEFHPFQNPV--ELIEYCRDNNIVFEGYCPLAKGKA 200
AKR_unchar cd19097
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 33-158 1.52e-07

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381323 [Multi-domain]  Cd Length: 267  Bit Score: 52.14  E-value: 1.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  33 RAFLERGHTEIDTAFVYseGQSETILGGLGLrlggSDCRVKIDTKaIPLFGNSLK--PDSLRFQLETSLKRLQCPRVDLF 110
Cdd:cd19097   33 EYALKAGINTLDTAPAY--GDSEKVLGKFLK----RLDKFKIITK-LPPLKEDKKedEAAIEASVEASLKRLKVDSLDGL 105

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767903246 111 YLHMPD----HSTPVEETLRachQLHQEGKFVELGLSNYAAWEVAEICTLCK 158
Cdd:cd19097  106 LLHNPDdllkHGGKLVEALL---ELKKEGLIRKIGVSVYSPEELEKALESFK 154
AKR_AKR1G1_CeAKR cd19154
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ...
 30-158 2.01e-07

Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381380 [Multi-domain]  Cd Length: 303  Bit Score: 52.03  E-value: 2.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  30 AVTRAFLERGHTEIDTAFVYsegQSETILGGLGLRLGGSDcRVK-----IDTKAIPLFgnsLKPDSLRFQLETSLKRLQC 104
Cdd:cd19154   29 TAVRTALKAGYRLIDTAFLY---QNEEAIGEALAELLEEG-VVKredlfITTKLWTHE---HAPEDVEEALRESLKKLQL 101

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767903246 105 PRVDLFYLHMP-----------------DHSTPV--EETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCK 158
Cdd:cd19154  102 EYVDLYLIHAPaafkddegesgtmengmSIHDAVdvEDVWRGMEKVYDEGLTKAIGVSNFNNDQIQRILDNAR 174
AKR_AKR5F1 cd19133
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ...
 94-203 2.85e-07

the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381359 [Multi-domain]  Cd Length: 255  Bit Score: 51.04  E-value: 2.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  94 QLETSLKRLQCPRVDLFYLHMPDHStpVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKsngwILPTVYQGMYN 173
Cdd:cd19133   85 AFERSLKRLGLDYLDLYLIHQPFGD--VYGAWRAMEELYKEGKIRAIGVSNFYPDRLVDLILHNE----VKPAVNQIETH 158

                         90       100       110
                 ....*....|....*....|....*....|
gi 767903246 174 AITRQVETELFpcLRHFGLRFYAFNPLAGG 203
Cdd:cd19133  159 PFNQQIEAVEF--LKKYGVQIEAWGPFAEG 186
AKR_AKR3C2-3 cd19120
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ...
 24-169 3.15e-07

Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.


Pssm-ID: 381346 [Multi-domain]  Cd Length: 269  Bit Score: 51.08  E-value: 3.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  24 DAPTSAAVTRAfLERGHTEIDTAFVYSEgQSETILGGLGLRLGGSDcrVKIDTKAIPlfgnslKPDSLRFQLETSLKRLQ 103
Cdd:cd19120   24 QRDLVDSVKLA-LKAGFRHIDTAEMYGN-EKEVGEALKESGVPRED--LFITTKVSP------GIKDPREALRKSLAKLG 93

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 104 CPRVDLFYLHMP----DHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKsngwILPTVYQ 169
Cdd:cd19120   94 VDYVDLYLIHSPffakEGGPTLAEAWAELEALKDAGLVRSIGVSNFRIEDLEELLDTAK----IKPAVNQ 159
AKR_DrGR-like cd19136
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ...
 30-206 4.28e-07

Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).


Pssm-ID: 381362 [Multi-domain]  Cd Length: 262  Bit Score: 50.71  E-value: 4.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  30 AVTRAFLERGHTEIDTAFVY-SEGQSETILGGLGLRLGGSDCRVKIDTKAIPLFGNSlkpDSLRFQLETSLKRLQCPRVD 108
Cdd:cd19136   19 QAVDAALKAGYRLIDTASVYrNEADIGKALRDLLPKYGLSREDIFITSKLAPKDQGY---EKARAACLGSLERLGTDYLD 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 109 LFYLHMP-----DHSTPVE-----ETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKsngwILPTVYQGMYNAitRQ 178
Cdd:cd19136   96 LYLIHWPgvqglKPSDPRNaelrrESWRALEDLYKEGKLRAIGVSNYTVRHLEELLKYCE----VPPAVNQVEFHP--HL 169

                        170       180
                 ....*....|....*....|....*...
gi 767903246 179 VETELFPCLRHFGLRFYAFNPLAGGLLT 206
Cdd:cd19136  170 VQKELLKFCKDHGIHLQAYSSLGSGDLR 197
AKR_AKR3F2 cd19139
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ...
 10-145 4.51e-07

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381365 [Multi-domain]  Cd Length: 248  Bit Score: 50.43  E-value: 4.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  10 PATVLGAmemGRRMDAPTSAAVTRAfLERGHTEIDTAFVY-SEGQ-SETIlgglglrlggSDCRVK-----IDTKaipLF 82
Cdd:cd19139    2 PAFGLGT---FRLKDDVVIDSVRTA-LELGYRHIDTAQIYdNEAAvGQAI----------AESGVPrdelfITTK---IW 64

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767903246  83 GNSLKPDSLRFQLETSLKRLQCPRVDLFYLHMP--DHSTPVEETLRACHQLHQEGKFVELGLSNY 145
Cdd:cd19139   65 IDNLSKDKLLPSLEESLEKLRTDYVDLTLIHWPspNDEVPVEEYIGALAEAKEQGLTRHIGVSNF 129
AKR_AKR2E1-5 cd19116
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ...
 24-169 1.51e-06

AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.


Pssm-ID: 381342 [Multi-domain]  Cd Length: 292  Bit Score: 49.20  E-value: 1.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  24 DAPTSAAVTRAfLERGHTEIDTAFVY------SEGQSETILGGLglrlggsdcrVK-----IDTKaipLFGNSLKPDSLR 92
Cdd:cd19116   24 DEGVRQAVKHA-IEAGYRHIDTAYLYgneaevGEAIREKIAEGV----------VKredlfITTK---LWNSYHEREQVE 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  93 FQLETSLKRLQCPRVDLFYLHMP------------DHSTPVE----ETLRACHQLHQEGKFVELGLSNYAAWEVAEICTL 156
Cdd:cd19116   90 PALRESLKRLGLDYVDLYLIHWPvafkenndsesnGDGSLSDidylETWRGMEDLVKLGLTRSIGVSNFNSEQINRLLSN 169

                        170
                 ....*....|...
gi 767903246 157 CKsngwILPTVYQ 169
Cdd:cd19116  170 CN----IKPAVNQ 178
AKR_AKR4C1-15 cd19125
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ...
 81-200 3.33e-06

AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.


Pssm-ID: 381351 [Multi-domain]  Cd Length: 287  Bit Score: 48.11  E-value: 3.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  81 LFGNSLKPDSLRFQLETSLKRLQCPRVDLFYLHMPDH--------------STPVEETLRACHQLHQEGKFVELGLSNYA 146
Cdd:cd19125   77 LWCTDHAPEDVPPALEKTLKDLQLDYLDLYLIHWPVRlkkgahmpepeevlPPDIPSTWKAMEKLVDSGKVRAIGVSNFS 156

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767903246 147 AWEVAEICTLCKsngwILPTVYQGMYNAITRQveTELFPCLRHFGLRFYAFNPL 200
Cdd:cd19125  157 VKKLEDLLAVAR----VPPAVNQVECHPGWQQ--DKLHEFCKSKGIHLSAYSPL 204
AKR_AKR8A1-2 cd19077
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ...
 87-210 3.87e-06

AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).


Pssm-ID: 381303 [Multi-domain]  Cd Length: 302  Bit Score: 48.00  E-value: 3.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  87 KPDSLRFQLETSLKRLQCP-RVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSnyaawEV-AEicTLCKSNGWIL 164
Cdd:cd19077   92 SPEAVRKSIENILRALGGTkKIDIFEPARVDPNVPIEETIKALKELVKEGKIRGIGLS-----EVsAE--TIRRAHAVHP 164

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 767903246 165 PTVYQGMYNAITRQVET-ELFPCLRHFGLRFYAFNPLAGGLLTGKYK 210
Cdd:cd19077  165 IAAVEVEYSLFSREIEEnGVLETCAELGIPIIAYSPLGRGLLTGRIK 211
AKR_unchar cd19104
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 19-135 4.35e-06

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381330 [Multi-domain]  Cd Length: 321  Bit Score: 48.03  E-value: 4.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  19 MGRRMDAPTSAAVTRAfLERGHTEIDTAFVYSEGQSETilGGLGLRLGGSDcRVKIDTK-AIPLFGNSLKPDSLRFQLET 97
Cdd:cd19104   26 MGRTTREEQIAAVRRA-LDLGINFFDTAPSYGDGKSEE--NLGRALKGLPA-GPYITTKvRLDPDDLGDIGGQIERSVEK 101

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 767903246  98 SLKRLQCPRVDLFYLH---MPDHSTPVEETLRACHQLHQEG 135
Cdd:cd19104  102 SLKRLKRDSVDLLQLHnriGDERDKPVGGTLSTTDVLGLGG 142
AKR_GlAR-like cd19128
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ...
 81-202 9.18e-06

Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.


Pssm-ID: 381354 [Multi-domain]  Cd Length: 277  Bit Score: 46.75  E-value: 9.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  81 LFGNSLKPDSLRFQLETSLKRLQCPRVDLFYLHMP-------------------DHSTPVEETLRACHQLHQEGKFVELG 141
Cdd:cd19128   67 LWPTMHQPENVKEQLLITLQDLQLEYLDLFLIHWPlafdmdtdgdprddnqiqsLSKKPLEDTWRAMEQCVDEKLTKNIG 146

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767903246 142 LSNYAAWEVAEICTLCKsngwILPtvyqgmynaITRQVETEL-FP-------CLRHfGLRFYAFNPLAG 202
Cdd:cd19128  147 VSNYSTKLLTDLLNYCK----IKP---------FMNQIECHPyFQndklikfCIEN-NIHVTAYRPLGG 201
AKR_AKR1A1-4 cd19106
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ...
 29-200 1.22e-05

AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.


Pssm-ID: 381332 [Multi-domain]  Cd Length: 305  Bit Score: 46.61  E-value: 1.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  29 AAVTRAfLERGHTEIDTAFVYSEGQS--ETILGGLGLRLGGSDCRVKIDTKaipLFGNSLKPDSLRFQLETSLKRLQCPR 106
Cdd:cd19106   24 AAVKYA-LDAGYRHIDCAAVYGNEQEvgEALKEKVGPGKAVPREDLFVTSK---LWNTKHHPEDVEPALRKTLKDLQLDY 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 107 VDLFYLHMP------DH-------------STPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICtlckSNGWILPTV 167
Cdd:cd19106  100 LDLYLIHWPyafergDNpfpknpdgtirydSTHYKETWKAMEKLVDKGLVKAIGLSNFNSRQIDDIL----SVARIKPAV 175

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 767903246 168 YqgmynaitrQVE-------TELFPCLRHFGLRFYAFNPL 200
Cdd:cd19106  176 L---------QVEchpylaqNELIAHCKARGLVVTAYSPL 206
AKR_AKR1I_CgAKR1 cd19155
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ...
 29-200 2.13e-05

Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.


Pssm-ID: 381381 [Multi-domain]  Cd Length: 307  Bit Score: 45.98  E-value: 2.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  29 AAVTRAfLERGHTEIDTAFVYsegQSETILGGLGLRLGGSDcRVK-----IDTKaIPLFGNslKPDSLRFQLETSLKRLQ 103
Cdd:cd19155   29 TAVDTA-LEAGYRHIDTAYVY---RNEAAIGNVLKKWIDSG-KVKreelfIVTK-LPPGGN--RREKVEKFLLKSLEKLQ 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 104 CPRVDLFYLHMP---------------------DHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKsngw 162
Cdd:cd19155  101 LDYVDLYLIHFPvgslskeddsgkldptgehkqDYTTDLLDIWKAMEAQVDQGLTRSIGLSNFNREQMARILKNAR---- 176

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 767903246 163 ILPTVYQGMYNAITRQVETELFpCLRHfGLRFYAFNPL 200
Cdd:cd19155  177 IKPANLQVELHVYLQQKDLVDF-CSTH-SITVTAYAPL 212
AKR_AKR5G1-3 cd19157
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ...
 96-203 2.19e-05

AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381383 [Multi-domain]  Cd Length: 265  Bit Score: 45.46  E-value: 2.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  96 ETSLKRLQCPRVDLFYLHMPDhSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKsngwILPTVYQGMYNAi 175
Cdd:cd19157   88 EASLERLGLDYLDLYLIHWPV-KGKYKETWKALEKLYKDGRVRAIGVSNFQVHHLEDLLADAE----IVPMVNQVEFHP- 161

                         90       100
                 ....*....|....*....|....*...
gi 767903246 176 tRQVETELFPCLRHFGLRFYAFNPLAGG 203
Cdd:cd19157  162 -RLTQKELRDYCKKQGIQLEAWSPLMQG 188
AKR_AKR5A1_2 cd19156
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ...
 19-205 2.42e-05

AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.


Pssm-ID: 381382 [Multi-domain]  Cd Length: 266  Bit Score: 45.59  E-value: 2.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  19 MGRRMDAPTSAAVTRAFLERGHTEIDTAFVYS--EGQSETILGGLGLRLggsdcRVKIDTKaipLFGNSLKPDSLRFQLE 96
Cdd:cd19156   16 VWRVQDGAEAENAVKWAIEAGYRHIDTAAIYKneEGVGQGIRESGVPRE-----EVFVTTK---LWNSDQGYESTLAAFE 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  97 TSLKRLQCPRVDLFYLHMPDHSTPVeETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKsngwILPTVYQgmynait 176
Cdd:cd19156   88 ESLEKLGLDYVDLYLIHWPVKGKFK-DTWKAFEKLYKEKKVRAIGVSNFHEHHLEELLKSCK----VAPMVNQ------- 155

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 767903246 177 rqveTELFPCLRHFGLRFY---------AFNPLAGGLL 205
Cdd:cd19156  156 ----IELHPLLTQEPLRKFckekniaveAWSPLGQGKL 189
AKR_BaDH-like cd19129
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ...
 24-204 5.50e-05

Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.


Pssm-ID: 381355 [Multi-domain]  Cd Length: 295  Bit Score: 44.37  E-value: 5.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  24 DAPTSAAVTRAFLERGHTEIDTAFVY-SEGQSETILGGLGLRLGGSDCRVKIDTKaipLFGNSLKPDSLRFQLETSLKRL 102
Cdd:cd19129   17 DPSATRNAVKAALEAGFRHFDCAERYrNEAEVGEAMQEVFKAGKIRREDLFVTTK---LWNTNHRPERVKPAFEASLKRL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 103 QCPRVDLFYLHMP--------------------DHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKsngw 162
Cdd:cd19129   94 QLDYLDLYLIHTPfafqpgdeqdprdangnviyDDGVTLLDTWRAMERLVDEGRCKAIGLSDVSLEKLREIFEAAR---- 169

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 767903246 163 ILPTVYQgmYNAITRQVETELFPCLRHFGLRFYAFNPLAGGL 204
Cdd:cd19129  170 IKPAVVQ--VESHPYLPEWELLDFCKNHGIVLQAFAPLGHGM 209
AKR_AKR5A_5G cd19126
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ...
 31-205 5.63e-05

AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381352 [Multi-domain]  Cd Length: 254  Bit Score: 44.35  E-value: 5.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  31 VTRAFLERGHTEIDTAFVYsegQSETILGGLGLRLGGSDCRVKIDTKaipLFGNSLKPDSLRFQLETSLKRLQCPRVDLF 110
Cdd:cd19126   28 AVQTALENGYRSIDTAAIY---KNEEGVGEAIRESGVPREELFVTTK---LWNDDQRARRTEDAFQESLDRLGLDYVDLY 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246 111 YLHMP--DHstpVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKsngwILPTVYQGMYNAitRQVETELFPCLR 188
Cdd:cd19126  102 LIHWPgkDK---FIDTWKALEKLYASGKVKAIGVSNFQEHHLEELLAHAD----VVPAVNQVEFHP--YLTQKELRGYCK 172

                        170
                 ....*....|....*..
gi 767903246 189 HFGLRFYAFNPLAGGLL 205
Cdd:cd19126  173 SKGIVVEAWSPLGQGGL 189
AKR_galDH cd19163
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ...
 95-145 7.50e-05

L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).


Pssm-ID: 381389 [Multi-domain]  Cd Length: 293  Bit Score: 44.08  E-value: 7.50e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767903246  95 LETSLKRLQCPRVDLFYLH----MPDHSTPVEETLRACHQLHQEGKFVELGLSNY 145
Cdd:cd19163  105 VEESLKRLGLDYIDIIQVHdiefAPSLDQILNETLPALQKLKEEGKVRFIGITGY 159
AKR_FDH cd19162
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ...
 10-205 1.19e-04

D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.


Pssm-ID: 381388 [Multi-domain]  Cd Length: 290  Bit Score: 43.50  E-value: 1.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  10 PATVLGAMEMGR--RMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDcrVKIDTKA--IPLFGNS 85
Cdd:cd19162    1 PRLGLGAASLGNlaRAGEDEAAATLDAAWDAGIRYFDTAPLYGLGLSERRLGAALARHPRAE--YVVSTKVgrLLEPGAA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  86 LKPDSLRFQ-----------LETSLKRLQCPRVDLFYLHMPDH--STPVEETLRACHQLHQEGKFVELGL---SNYAAWE 149
Cdd:cd19162   79 GRPAGADRRfdfsadgirrsIEASLERLGLDRLDLVFLHDPDRhlLQALTDAFPALEELRAEGVVGAIGVgvtDWAALLR 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767903246 150 VAEIctlcksNGW--ILPTvyqGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLL 205
Cdd:cd19162  159 AARR------ADVdvVMVA---GRYTLLDRRAATELLPLCAAKGVAVVAAGVFNSGIL 207
AKR_AKR3G1 cd19123
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ...
 29-145 2.23e-04

AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.


Pssm-ID: 381349 [Multi-domain]  Cd Length: 297  Bit Score: 42.78  E-value: 2.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  29 AAVTRAfLERGHTEIDTAFVYseGQSETILGGLGLRLGGSDCR---VKIDTKaipLFGNSLKPDSLRFQLETSLKRLQCP 105
Cdd:cd19123   29 QAVKQA-LEAGYRHIDCAAIY--GNEAEIGAALAEVFKEGKVKredLWITSK---LWNNSHAPEDVLPALEKTLADLQLD 102

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767903246 106 RVDLFYLHMP---------DHST---------PVEETLRACHQLHQEGKFVELGLSNY 145
Cdd:cd19123  103 YLDLYLMHWPvalkkgvgfPESGedllslspiPLEDTWRAMEELVDKGLCRHIGVSNF 160
AKR_galDH-like cd19153
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ...
 26-145 2.26e-04

L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).


Pssm-ID: 381379 [Multi-domain]  Cd Length: 294  Bit Score: 42.52  E-value: 2.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  26 PTSAAVTRAFlERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKA--IPLFGNSLKPDSLRFQLETSLKRLQ 103
Cdd:cd19153   34 EAVAIVAEAF-AAGINHFDTSPYYGAESSEAVLGKALAALQVPRSSYTVATKVgrYRDSEFDYSAERVRASVATSLERLH 112

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 767903246 104 CPRVDLFYLH---MPDHSTPVEETLRACHQLHQEGKFVELGLSNY 145
Cdd:cd19153  113 TTYLDVVYLHdieFVDYDTLVDEALPALRTLKDEGVIKRIGIAGY 157
AKR_AKR5C1 cd19130
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ...
 24-145 1.34e-03

Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.


Pssm-ID: 381356 [Multi-domain]  Cd Length: 256  Bit Score: 39.89  E-value: 1.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  24 DAPTSAAVTRAfLERGHTEIDTAFVY--SEGQSETILGGLGLRLggsdcRVKIDTKaipLFGNSLKPDSLRFQLETSLKR 101
Cdd:cd19130   22 PADTQRAVATA-LEVGYRHIDTAAIYgnEEGVGAAIAASGIPRD-----ELFVTTK---LWNDRHDGDEPAAAFAESLAK 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 767903246 102 LQCPRVDLFYLHMPdhsTPVE----ETLRACHQLHQEGKFVELGLSNY 145
Cdd:cd19130   93 LGLDQVDLYLVHWP---TPAAgnyvHTWEAMIELRAAGRTRSIGVSNF 137
AKR_AKR5H1 cd19134
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ...
 7-205 1.53e-03

AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.


Pssm-ID: 381360 [Multi-domain]  Cd Length: 263  Bit Score: 39.84  E-value: 1.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246   7 RARPATVLGAMEMGrrmDAPTSAAVTRAfLERGHTEIDTAFVYSegqSETILGGLGLRLGGSDCRVKIDTK-AIPLFGNS 85
Cdd:cd19134    9 NTMPVIGLGVGELS---DDEAERSVSAA-LEAGYRLIDTAAAYG---NEAAVGRAIAASGIPRGELFVTTKlATPDQGFT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  86 LKPDSLRfqleTSLKRLQCPRVDLFYLHMP--DHSTPVeETLRACHQLHQEGKFVELGLSNYAAWEVAEICtlckSNGWI 163
Cdd:cd19134   82 ASQAACR----ASLERLGLDYVDLYLIHWPagREGKYV-DSWGGLMKLREEGLARSIGVSNFTAEHLENLI----DLTFF 152

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767903246 164 LPTVYQgmynaitrqveTELFPCLRHFGLRFY---------AFNPLAGGLL 205
Cdd:cd19134  153 TPAVNQ-----------IELHPLLNQAELRKVnaqhgivtqAYSPLGVGRL 192
AKR_AKR15A cd19152
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ...
 94-207 1.97e-03

AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.


Pssm-ID: 381378 [Multi-domain]  Cd Length: 308  Bit Score: 39.51  E-value: 1.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  94 QLETSLKRLQCPRVDLFYLHMPDHSTPVEETL-----------RACHQLHQEGKFVELGL-SNyaAWEVAE-ICTLCKSN 160
Cdd:cd19152  108 SIEDSLQRLGLSRIDLLSIHDPDEDLAGAESDehfaqaikgafRALEELREEGVIKAIGLgVN--DWEVILrILEEADLD 185

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 767903246 161 gWILptvYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTG 207
Cdd:cd19152  186 -WVM---LAGRYTLLDHSAARELLPECEKRGVKVVNAGPFNSGFLAG 228
AKR_AKR1C1-35 cd19108
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ...
 26-161 2.72e-03

AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.


Pssm-ID: 381334 [Multi-domain]  Cd Length: 303  Bit Score: 39.14  E-value: 2.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903246  26 PTSAAV--TRAFLERGHTEIDTAFVYSE----GQS--ETIlgglglrlggSDCRVK-----IDTKaipLFGNSLKPDSLR 92
Cdd:cd19108   25 PKSKALeaTKLAIDAGFRHIDSAYLYQNeeevGQAirSKI----------ADGTVKredifYTSK---LWCTFHRPELVR 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767903246  93 FQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRAchqlHQEGKF----VELglsnYAAWEVAEICT---LCKSNG 161
Cdd:cd19108   92 PALEKSLKKLQLDYVDLYLIHFPVALKPGEELFPK----DENGKLifdtVDL----CATWEAMEKCKdagLAKSIG 159
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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