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Conserved domains on  [gi|767903806|ref|XP_011539563|]
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glutamate--cysteine ligase regulatory subunit isoform X2 [Homo sapiens]

Protein Classification

aldo-keto reductase family protein( domain architecture ID 305)

aldo-keto reductase family protein may be an NAD(P)(H) oxidoreductase that reduces aldehydes and ketones to primary and secondary alcohols

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AKR_SF super family cl00470
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ...
 21-123 1.48e-10

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.


The actual alignment was detected with superfamily member cd19071:

Pssm-ID: 444925 [Multi-domain]  Cd Length: 251  Bit Score: 58.26  E-value: 1.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903806  21 AVDMACSVLGVAQLDSVIIASPPIEDGVNLSLEHLQPyWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQV 100
Cdd:cd19071   76 ALEESLKDLGLDYLDLYLIHWPVPGKEGGSKEARLET-WRALEELVDEGLVRSIGVSNFNVEHLEELLAAARIKPAVNQI 154

                         90       100
                 ....*....|....*....|...
gi 767903806 101 NLASCCVmPPDLTAFAKQFDIQL 123
Cdd:cd19071  155 ELHPYLQ-QKELVEFCKEHGIVV 176
 
Name Accession Description Interval E-value
AKR_AKR1-5-like cd19071
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ...
 21-123 1.48e-10

AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.


Pssm-ID: 381297 [Multi-domain]  Cd Length: 251  Bit Score: 58.26  E-value: 1.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903806  21 AVDMACSVLGVAQLDSVIIASPPIEDGVNLSLEHLQPyWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQV 100
Cdd:cd19071   76 ALEESLKDLGLDYLDLYLIHWPVPGKEGGSKEARLET-WRALEELVDEGLVRSIGVSNFNVEHLEELLAAARIKPAVNQI 154

                         90       100
                 ....*....|....*....|...
gi 767903806 101 NLASCCVmPPDLTAFAKQFDIQL 123
Cdd:cd19071  155 ELHPYLQ-QKELVEFCKEHGIVV 176
ARA1 COG0656
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...
 29-123 2.83e-05

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440421 [Multi-domain]  Cd Length: 259  Bit Score: 43.12  E-value: 2.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903806  29 LGVAQLDSVIIASPPIEDgvnlslehLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQV--NLAScc 106
Cdd:COG0656   88 LGLDYLDLYLIHWPGPGP--------YVETWRALEELYEEGLIRAIGVSNFDPEHLEELLAETGVKPAVNQVelHPYL-- 157

                         90
                 ....*....|....*..
gi 767903806 107 vMPPDLTAFAKQFDIQL 123
Cdd:COG0656  158 -QQRELLAFCREHGIVV 173
 
Name Accession Description Interval E-value
AKR_AKR1-5-like cd19071
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ...
 21-123 1.48e-10

AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.


Pssm-ID: 381297 [Multi-domain]  Cd Length: 251  Bit Score: 58.26  E-value: 1.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903806  21 AVDMACSVLGVAQLDSVIIASPPIEDGVNLSLEHLQPyWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQV 100
Cdd:cd19071   76 ALEESLKDLGLDYLDLYLIHWPVPGKEGGSKEARLET-WRALEELVDEGLVRSIGVSNFNVEHLEELLAAARIKPAVNQI 154

                         90       100
                 ....*....|....*....|...
gi 767903806 101 NLASCCVmPPDLTAFAKQFDIQL 123
Cdd:cd19071  155 ELHPYLQ-QKELVEFCKEHGIVV 176
AKR_AKR3C2-3 cd19120
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ...
 29-123 2.27e-09

Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.


Pssm-ID: 381346 [Multi-domain]  Cd Length: 269  Bit Score: 54.93  E-value: 2.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903806  29 LGVAQLDSVIIASPPIEDGVNLSLEHLqpyWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLASCCVM 108
Cdd:cd19120   92 LGVDYVDLYLIHSPFFAKEGGPTLAEA---WAELEALKDAGLVRSIGVSNFRIEDLEELLDTAKIKPAVNQIEFHPYLYP 168

                         90
                 ....*....|....*.
gi 767903806 109 P-PDLTAFAKQFDIQL 123
Cdd:cd19120  169 QqPALLEYCREHGIVV 184
AKR_DrGR-like cd19136
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ...
 21-123 1.23e-05

Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).


Pssm-ID: 381362 [Multi-domain]  Cd Length: 262  Bit Score: 44.16  E-value: 1.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903806  21 AVDMACSVLGVAQLDSVIIASP-----PIEDGVNLSLEHLQpyWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKP 95
Cdd:cd19136   81 ACLGSLERLGTDYLDLYLIHWPgvqglKPSDPRNAELRRES--WRALEDLYKEGKLRAIGVSNYTVRHLEELLKYCEVPP 158

                         90       100
                 ....*....|....*....|....*...
gi 767903806  96 NSNQVNLASCCVMpPDLTAFAKQFDIQL 123
Cdd:cd19136  159 AVNQVEFHPHLVQ-KELLKFCKDHGIHL 185
AKR_AKR3E1 cd19122
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ...
 53-102 1.36e-05

AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.


Pssm-ID: 381348 [Multi-domain]  Cd Length: 291  Bit Score: 44.15  E-value: 1.36e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 767903806  53 EHLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNL 102
Cdd:cd19122  139 ENPEPTWRAMEEIYESGKAKAIGVSNWTIPGLKKLLSFAKVKPHVNQIEI 188
AKR_CeZK1290-like cd19135
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ...
 26-122 2.08e-05

Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.


Pssm-ID: 381361 [Multi-domain]  Cd Length: 265  Bit Score: 43.47  E-value: 2.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903806  26 CSVLGVAQLDSVIIASPPIEDGVNLSLEHLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLaSC 105
Cdd:cd19135   93 LKRLGVDYLDLYLLHWPDCPSSGKNVKETRAETWRALEELYDEGLCRAIGVSNFLIEHLEQLLEDCSVVPHVNQVEF-HP 171

                         90
                 ....*....|....*..
gi 767903806 106 CVMPPDLTAFAKQFDIQ 122
Cdd:cd19135  172 FQNPVELIEYCRDNNIV 188
ARA1 COG0656
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...
 29-123 2.83e-05

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440421 [Multi-domain]  Cd Length: 259  Bit Score: 43.12  E-value: 2.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903806  29 LGVAQLDSVIIASPPIEDgvnlslehLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQV--NLAScc 106
Cdd:COG0656   88 LGLDYLDLYLIHWPGPGP--------YVETWRALEELYEEGLIRAIGVSNFDPEHLEELLAETGVKPAVNQVelHPYL-- 157

                         90
                 ....*....|....*..
gi 767903806 107 vMPPDLTAFAKQFDIQL 123
Cdd:COG0656  158 -QQRELLAFCREHGIVV 173
AKR_AKR5A_5G cd19126
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ...
 53-123 4.92e-05

AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381352 [Multi-domain]  Cd Length: 254  Bit Score: 42.42  E-value: 4.92e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767903806  53 EHLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLaSCCVMPPDLTAFAKQFDIQL 123
Cdd:cd19126  109 DKFIDTWKALEKLYASGKVKAIGVSNFQEHHLEELLAHADVVPAVNQVEF-HPYLTQKELRGYCKSKGIVV 178
AKR_AKR4C1-15 cd19125
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ...
 59-100 1.54e-04

AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.


Pssm-ID: 381351 [Multi-domain]  Cd Length: 287  Bit Score: 41.18  E-value: 1.54e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 767903806  59 WEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQV 100
Cdd:cd19125  135 WKAMEKLVDSGKVRAIGVSNFSVKKLEDLLAVARVPPAVNQV 176
AKR_AKR2E1-5 cd19116
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ...
 21-121 1.55e-04

AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.


Pssm-ID: 381342 [Multi-domain]  Cd Length: 292  Bit Score: 41.11  E-value: 1.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903806  21 AVDMACSVLGVAQLDSVIIASPP--IEDGVNLSLEHLQP----Y---WEELENLVQSKKIVAIGTSDLDKTQLEQLYQWA 91
Cdd:cd19116   91 ALRESLKRLGLDYVDLYLIHWPVafKENNDSESNGDGSLsdidYletWRGMEDLVKLGLTRSIGVSNFNSEQINRLLSNC 170

                         90       100       110
                 ....*....|....*....|....*....|....
gi 767903806  92 QVKPNSNQVNlasccVMP----PDLTAFAKQFDI 121
Cdd:cd19116  171 NIKPAVNQIE-----VHPtltqEKLVAYCQSNGI 199
AKR_AKR5G1-3 cd19157
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ...
 59-123 1.62e-04

AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381383 [Multi-domain]  Cd Length: 265  Bit Score: 40.84  E-value: 1.62e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767903806  59 WEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLAScCVMPPDLTAFAKQFDIQL 123
Cdd:cd19157  116 WKALEKLYKDGRVRAIGVSNFQVHHLEDLLADAEIVPMVNQVEFHP-RLTQKELRDYCKKQGIQL 179
AKR_AKR3D1 cd19121
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ...
 59-102 3.02e-04

AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.


Pssm-ID: 381347 [Multi-domain]  Cd Length: 279  Bit Score: 40.21  E-value: 3.02e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 767903806  59 WEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNL 102
Cdd:cd19121  141 WKQMEKVLKTGKTKAIGVSNYSIPYLEELLKHATVVPAVNQVEN 184
AKR_AKR1G1_CeAKR cd19154
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ...
 59-121 3.72e-04

Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381380 [Multi-domain]  Cd Length: 303  Bit Score: 40.09  E-value: 3.72e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767903806  59 WEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLAscCVMP-PDLTAFAKQFDI 121
Cdd:cd19154  141 WRGMEKVYDEGLTKAIGVSNFNNDQIQRILDNARVKPHNNQVECH--LYFPqKELVEFCKKHNI 202
AKR_AKR5A1_2 cd19156
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ...
 59-121 5.80e-04

AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.


Pssm-ID: 381382 [Multi-domain]  Cd Length: 266  Bit Score: 39.42  E-value: 5.80e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767903806  59 WEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLASCCVMPPdLTAFAKQFDI 121
Cdd:cd19156  115 WKAFEKLYKEKKVRAIGVSNFHEHHLEELLKSCKVAPMVNQIELHPLLTQEP-LRKFCKEKNI 176
AKR_AKR3G1 cd19123
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ...
 45-123 5.88e-04

AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.


Pssm-ID: 381349 [Multi-domain]  Cd Length: 297  Bit Score: 39.32  E-value: 5.88e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767903806  45 EDGVNLSLEHLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLaSCCVMPPDLTAFAKQFDIQL 123
Cdd:cd19123  126 EDLLSLSPIPLEDTWRAMEELVDKGLCRHIGVSNFSVKKLEDLLATARIKPAVNQVEL-HPYLQQPELLAFCRDNGIHL 203
AKR_AKR5F1 cd19133
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ...
 46-102 5.99e-04

the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381359 [Multi-domain]  Cd Length: 255  Bit Score: 39.09  E-value: 5.99e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767903806  46 DGVNLSLEHlQPY------WEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNL 102
Cdd:cd19133   96 DYLDLYLIH-QPFgdvygaWRAMEELYKEGKIRAIGVSNFYPDRLVDLILHNEVKPAVNQIET 157
AKR_GlAR-like cd19128
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ...
 45-168 1.11e-03

Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.


Pssm-ID: 381354 [Multi-domain]  Cd Length: 277  Bit Score: 38.66  E-value: 1.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903806  45 EDGVNLSLEHLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLASccVMPPD-LTAFAKQFDIQL 123
Cdd:cd19128  116 NQIQSLSKKPLEDTWRAMEQCVDEKLTKNIGVSNYSTKLLTDLLNYCKIKPFMNQIECHP--YFQNDkLIKFCIENNIHV 193

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767903806 124 LTHN-------DPKELLSEASFQEALQE----SIPDIQAHEWVPLWLLRYSVIVKS 168
Cdd:cd19128  194 TAYRplggsygDGNLTFLNDSELKALATkyntTPPQVIIAWHLQKWPKNYSVIPKS 249
AKR_BaDH-like cd19129
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ...
 45-100 1.23e-03

Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.


Pssm-ID: 381355 [Multi-domain]  Cd Length: 295  Bit Score: 38.59  E-value: 1.23e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767903806  45 EDGVNLSlehlqPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQV 100
Cdd:cd19129  127 DDGVTLL-----DTWRAMERLVDEGRCKAIGLSDVSLEKLREIFEAARIKPAVVQV 177
AKR_AKR5B1 cd19127
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ...
 46-102 5.18e-03

AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.


Pssm-ID: 381353 [Multi-domain]  Cd Length: 268  Bit Score: 36.62  E-value: 5.18e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767903806  46 DGVNLSLEHlQPY----------WEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNL 102
Cdd:cd19127   95 DYVDLYLLH-WPVpndfdrtiqaYKALEKLLAEGRVRAIGVSNFTPEHLERLIDATTVVPAVNQVEL 160
AKR_AKR3A1-2 cd19117
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ...
 59-123 7.76e-03

AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.


Pssm-ID: 381343 [Multi-domain]  Cd Length: 284  Bit Score: 35.94  E-value: 7.76e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767903806  59 WEELENLVQSKKIVAIGTSDLDKTQLEQLY--QWAQVKPNSNQVNLASccVMP-PDLTAFAKQFDIQL 123
Cdd:cd19117  139 WELMQKLPATGKVKAIGVSNFSIKNLEKLLasPSAKIVPAVNQIELHP--LLPqPKLVDFCKSKGIHA 204
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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