|
Name |
Accession |
Description |
Interval |
E-value |
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
431-616 |
8.94e-28 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 120.35 E-value: 8.94e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905256 431 AMLAKQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVAL-FLYhvV 509
Cdd:COG1033 188 AIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLgLMG--L 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905256 510 FGIQyLGILNGVAAFVIVGIGVDDVFVFINTYRQAT-HLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVH 588
Cdd:COG1033 266 LGIP-LSPLTILVPPLLLAIGIDYGIHLLNRYREERrKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIR 344
|
170 180
....*....|....*....|....*...
gi 767905256 589 DFGLFMSLIVSCCWLAVLVTMPAALGLW 616
Cdd:COG1033 345 DFGIVAAIGVLLAFLTSLTLLPALLSLL 372
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
485-615 |
9.75e-14 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 69.53 E-value: 9.75e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905256 485 VFLSFFGIASIGLS--CLVALFLYhvvFGIQYLGILNGVAAFVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTVQTAG 562
Cdd:pfam12349 6 FGLGLAGVIIVLASvaSSLGLCAY---FGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDVSERIAEALGEVG 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 767905256 563 KATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGL 615
Cdd:pfam12349 83 PSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSL 135
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
441-615 |
7.10e-11 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 66.01 E-value: 7.10e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905256 441 VQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALfLYHVVFGIQYLGILNG 520
Cdd:TIGR00921 547 VKVGVTGLPVAFAEMHELVNEGMRRMTIAGAILVLMILLAVFRNPIKAVFPLIAIGSGILWAI-GLMGLRGIPSFLAMAT 625
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905256 521 VAAfVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSC 600
Cdd:TIGR00921 626 TIS-IILGLGMDYSIHLAERYFEERKEHGPKEAITHTMERTGPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLS 704
|
170
....*....|....*
gi 767905256 601 CWLAVLVTMPAALGL 615
Cdd:TIGR00921 705 SLTAALVVFPALLVL 719
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
431-616 |
8.94e-28 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 120.35 E-value: 8.94e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905256 431 AMLAKQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVAL-FLYhvV 509
Cdd:COG1033 188 AIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLgLMG--L 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905256 510 FGIQyLGILNGVAAFVIVGIGVDDVFVFINTYRQAT-HLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVH 588
Cdd:COG1033 266 LGIP-LSPLTILVPPLLLAIGIDYGIHLLNRYREERrKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIR 344
|
170 180
....*....|....*....|....*...
gi 767905256 589 DFGLFMSLIVSCCWLAVLVTMPAALGLW 616
Cdd:COG1033 345 DFGIVAAIGVLLAFLTSLTLLPALLSLL 372
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
386-616 |
1.95e-19 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 93.77 E-value: 1.95e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905256 386 SADNLKSSLLRSEILFGAPLPNYYSVD---------------DRWEEQRAKFQSFVVTYVAmlakqsTSKVQVLYGGTDL 450
Cdd:COG1033 521 SRELLAQLLLLLSSPPGDDLSRFVDEDysaarvtvrlkdldsEEIKALVEEVRAFLAENFP------PDGVEVTLTGSAV 594
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905256 451 FDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLScLVALFLYHVVFGIQyLGILNGVAAFVIVGIG 530
Cdd:COG1033 595 LFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNLLP-ILLTFGLMGLLGIP-LNIATAVVASIALGIG 672
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905256 531 VDDVFVFINTYRQA-THLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTM 609
Cdd:COG1033 673 VDYTIHFLSRYREErRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLL 752
|
....*..
gi 767905256 610 PAALGLW 616
Cdd:COG1033 753 PALLLLL 759
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
485-615 |
9.75e-14 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 69.53 E-value: 9.75e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905256 485 VFLSFFGIASIGLS--CLVALFLYhvvFGIQYLGILNGVAAFVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTVQTAG 562
Cdd:pfam12349 6 FGLGLAGVIIVLASvaSSLGLCAY---FGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDVSERIAEALGEVG 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 767905256 563 KATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGL 615
Cdd:pfam12349 83 PSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSL 135
|
|
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
412-613 |
1.36e-12 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 71.62 E-value: 1.36e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905256 412 DDRWEEQRAKFqsFVVTYVAMLAKQSTSK-VQVLYGGTDLFDYEVRRtfNNDMLLAFISSSCIAALVYILTSCSVFLSFF 490
Cdd:pfam02460 166 DEEEVEEDSKE--WEDELSQLLHNKYASEhIQFTIFHDQILNDELVR--NALTLTPFFVIGFFLLLTFSIIVSVTLSSYT 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905256 491 -------------GIASIGLSCLVAL-FLYhvVFGIQYLGILNgVAAFVIVGIGVDDVFVFINTYRQATHLEDPQLRMIH 556
Cdd:pfam02460 242 idwvrskpilaalGLLSPVMAIVSSFgLLF--WMGFPFNSIVC-VTPFLVLAIGVDDMFLMVAAWQRTTATLSVKKRMGE 318
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 767905256 557 TVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLvTMPAAL 613
Cdd:pfam02460 319 ALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQI-TFFAAI 374
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
441-615 |
7.10e-11 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 66.01 E-value: 7.10e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905256 441 VQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALfLYHVVFGIQYLGILNG 520
Cdd:TIGR00921 547 VKVGVTGLPVAFAEMHELVNEGMRRMTIAGAILVLMILLAVFRNPIKAVFPLIAIGSGILWAI-GLMGLRGIPSFLAMAT 625
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905256 521 VAAfVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSC 600
Cdd:TIGR00921 626 TIS-IILGLGMDYSIHLAERYFEERKEHGPKEAITHTMERTGPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLS 704
|
170
....*....|....*
gi 767905256 601 CWLAVLVTMPAALGL 615
Cdd:TIGR00921 705 SLTAALVVFPALLVL 719
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
426-615 |
3.66e-10 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 62.31 E-value: 3.66e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905256 426 VVTYVAMLAKQSTSKVQVlyGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSC-----L 500
Cdd:pfam03176 109 VRDAVEQAPPPEGLKAYL--TGPAATVADLRDAGDRDLGLIEAVTLVVIFIILLIVYRSVVAALLPLLTVGLSLgaaqgL 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905256 501 VALFLYHVVFGIQYLGIlnGVAAFVIVGIGVDDVFVFINTYRQATHL-EDPQLRMIHTVQTAGKATFFTSLTTAAAYAAN 579
Cdd:pfam03176 187 VAILAHILGIGLSTFAL--NLLVVLLIAVGTDYALFLVSRYREELRAgEDREEAVIRAVRGTGKVVTAAGLTVAIAMLAL 264
|
170 180 190
....*....|....*....|....*....|....*.
gi 767905256 580 VFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGL 615
Cdd:pfam03176 265 SFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLAL 300
|
|
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
407-615 |
3.96e-10 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 63.75 E-value: 3.96e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905256 407 NYYSVDDRWEEQRAKF------QSFVVTYVAMLAKQSTSKVQVlYGGTDLfdyevrrtfnNDMLLAFISSSCI----AAL 476
Cdd:TIGR00918 339 YYKVHHIGWNEEKAAAvleawqRNFSEEVQQSLPKNSSQKILV-FSSTTL----------DDILKKFSDVSAIrivsGYL 407
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905256 477 VYILTSCSVFL--------SFFGIASIGLSCL-VALFL-YHVVFGIQYLGILNGVAAFVIVGIGVDDVFVFINTYRQATH 546
Cdd:TIGR00918 408 LMLAYACLTMLrwdcaksqGSVGLAGVLLVALsVAAGLgLCALLGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQ 487
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767905256 547 LEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGL 615
Cdd:TIGR00918 488 NIPFEERTGECLKRTGASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSL 556
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
440-613 |
1.36e-09 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 61.78 E-value: 1.36e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905256 440 KVQVLYGGTDLfDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIAsiglsclVALFLYHVVFGIQ-YLGI- 517
Cdd:TIGR00921 173 KFLDVTGSPAI-NYDIEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLV-------IILFGVAWVLGIMgWLGIp 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905256 518 ----LNGVAAfVIVGIGVDDVFVFINTYRQATHL-EDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGL 592
Cdd:TIGR00921 245 lyatTLLAVP-MLIGVGIDYGIQTLNRYEEERDIgRAKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGL 323
|
170 180
....*....|....*....|.
gi 767905256 593 FMSLIVSCCWLAVLVTMPAAL 613
Cdd:TIGR00921 324 GLVAGLITAYLLTLLVLPALL 344
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
433-615 |
4.18e-09 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 60.16 E-value: 4.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905256 433 LAKQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFF----GIASIGLSCLVALFLYHV 508
Cdd:COG2409 141 VAAAPAPGLTVYVTGPAALAADLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLplltAGLAVGVALGLLALLAAF 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905256 509 V-FGIQYLGIlngvaAFVIV-GIGVDDVFVFINTYRQA-THLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIP 585
Cdd:COG2409 221 TdVSSFAPNL-----LTMLGlGVGIDYALFLVSRYREElRAGEDREEAVARAVATAGRAVLFSGLTVAIALLGLLLAGLP 295
|
170 180 190
....*....|....*....|....*....|
gi 767905256 586 AVHDFGLFMSLIVSCCWLAVLVTMPAALGL 615
Cdd:COG2409 296 FLRSMGPAAAIGVAVAVLAALTLLPALLAL 325
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
449-614 |
2.39e-07 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 54.62 E-value: 2.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905256 449 DLFDYEVRRTFNNDMLLafISSSCIAALVYILTSCSV----FLSFFGIASIGLSCL----------VALFLYHVVFGIQY 514
Cdd:TIGR03480 675 DLNDNEALRRFVRAVRK--VAPDATGAPVSILESGDTvvgaFLQAFIYALVAITVLllltlrrvrdVLLVLAPLLLAGLL 752
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905256 515 LGIL-----------NGVAAFVIVGIGVDDVFVFINTYRQATHLEDPqlrmIHTvqTAGKATFFTSLTTAAAYAANVFSQ 583
Cdd:TIGR03480 753 TVAAmvllgipfnfaNIIALPLLLGLGVDFGIYMVHRWRNGVDSGNL----LQS--STARAVFFSALTTATAFGSLAVSS 826
|
170 180 190
....*....|....*....|....*....|.
gi 767905256 584 IPAVHDFGLFMSLIVSCCWLAVLVTMPAALG 614
Cdd:TIGR03480 827 HPGTASMGILLSLGLGLTLLCTLIFLPALLG 857
|
|
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
375-615 |
2.66e-07 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 54.53 E-value: 2.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905256 375 PEFYWYVDEGLSADNLKSSllrSEILFGAPLPNYYSVDDRWEEQRAKFQSFVVTYVAMLAKQSTSKVQvlYGGTDLFDYE 454
Cdd:TIGR00917 491 PVDPTTVLGGFSGNNFSEA---SAFVVTFPVNNFVNKTNKTEKAVAWEKAFIQLAKDELLPMVQATIS--FSAERSIEDE 565
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905256 455 VRRTFNNDM---------LLAFISSSC--IAALVYILTSCSVFLSFFGIASIGLSCLVALFLYHVVfGIQYLGILNGVAA 523
Cdd:TIGR00917 566 LKRESTADVitiaisylvMFAYISLTLgdSPRLKSLYVTSKVLLGLSGILIVMLSVLGSVGVFSAV-GLKSTLIIMEVIP 644
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905256 524 FVIVGIGVDDVFVFINTY------RQATHLEDPQL-----RMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGL 592
Cdd:TIGR00917 645 FLVLAVGVDNIFILVFFYfyleyfYRQVGVDNEQEltlerRLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSM 724
|
250 260
....*....|....*....|...
gi 767905256 593 FMSLIVSCCWLAVLVTMPAALGL 615
Cdd:TIGR00917 725 FAVLAVFLDFLLQITAFVALLVL 747
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
434-612 |
1.90e-06 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 51.78 E-value: 1.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905256 434 AKQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALFLYHVVFGiq 513
Cdd:COG4258 222 LNAAFPGAQLLLTGAGLFAVAAAQQIKHDISTIGLISLLGILLLLLLVFRSLRPLLLGLLPVAVGALAGLAAVSLVFG-- 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905256 514 YLGILNGVAAFVIVGIGVDDVFVFInTYRQATHLEDPQlrmiHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLF 593
Cdd:COG4258 300 SVHGITLGFGSSLIGVAVDYSLHYL-THRRAAGEWDPR----AALRRIWPTLLLGLLTTVLGYLALLFSPFPGLRQLGVF 374
|
170 180
....*....|....*....|....*
gi 767905256 594 --MSLIVSC----CWLAVLVTMPAA 612
Cdd:COG4258 375 aaAGLLAAAlttlLWLPLLLPRAAP 399
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
474-611 |
6.09e-04 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 43.69 E-value: 6.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905256 474 AALVYILTSCSVFLSFFGI-------ASIGLSCLVALFLYhVVFGIQyLGILNGVAAFVIVGIGVD-DVFVfintyRQAT 545
Cdd:COG4258 645 LLLALLLILLLLLLRLRSLrralrvlLPPLLAVLLTLAIL-GLLGIP-LNLFHLIALLLVLGIGIDyALFF-----TEGL 717
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767905256 546 HLEDPQLRMIHTVqtagkatFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPA 611
Cdd:COG4258 718 LDKGELARTLLSI-------LLAALTTLLGFGLLAFSSTPALRSFGLTVLLGILLALLLAPLLAPR 776
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
437-616 |
1.11e-03 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 42.68 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905256 437 STSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTscsvFLSFFGIASIgLSCLVALFLYHVVFGIQYLG 516
Cdd:TIGR03480 245 EDHGVTVRLTGEVALSDEELATVSEGATVAGLLSFVLVLVLLWLA----LRSPRLVFAV-LVTLIVGLILTAAFATLAVG 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905256 517 ILNGVA-AFVI--VGIGVDDVFVFINTYRQATHLEDPQLRMIH-TVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGL 592
Cdd:TIGR03480 320 HLNLISvAFAVlfIGLGVDFAIQFSLRYREERFRGGNHREALSvAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGI 399
|
170 180
....*....|....*....|....
gi 767905256 593 FMSLIVSCCWLAVLVTMPAALGLW 616
Cdd:TIGR03480 400 IAGTGMFIALFVTLTVLPALLRLL 423
|
|
| actII |
TIGR00833 |
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ... |
459-617 |
4.50e-03 |
|
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 129913 [Multi-domain] Cd Length: 910 Bit Score: 40.72 E-value: 4.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905256 459 FNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALflyHVVFGIQYLGILnGVAAF-------VIVGIGV 531
Cdd:TIGR00833 171 GDKDMNRITATTGIIVLIILLLVYRSPITMLVPLVSVGFSVVVAQ---GIVSLLGIPGLI-GVNAQttvlltaLVIGAGT 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905256 532 DDVFVFINTYRQAT-HLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMP 610
Cdd:TIGR00833 247 DYAVFLTGRYHEERrKGESLEEAAAEALRGTGKAILGSALTVAVAFLALSLARLPSFKTLGVSCAVGVLVALLNAVTLTP 326
|
....*..
gi 767905256 611 AALGLWS 617
Cdd:TIGR00833 327 ALLTLEG 333
|
|
|