NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767935830|ref|XP_011541672|]
View 

solute carrier organic anion transporter family member 4C1 isoform X1 [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 143-516 0e+00

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17463:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 429  Bit Score: 546.65  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 143 VFILGQLLLGAGGTPLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYIDVAMGESTDVTEDDPRW 222
Cdd:cd17463   93 VFILGQLLLGVGGTPLYTLGTAYIDDSVPTHKSSLYIGIGYGMSVLGPAIGYLLGGQLLNIYIDVNKGQSVDLTEEDPRW 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 223 LGAWWIGFLLSWIFAWSLIIPFSCFPKHLPGtaeiqagktsqahqsnsnadvkfgksikdfpaalknLMKNAVFMCLVLS 302
Cdd:cd17463  173 LGAWWIGFLMCWLIAWCLIAPFSCFPKHLPG------------------------------------LLKNPVFMCLTIS 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 303 TSSEALITTGFATFLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGFLVSKFRMTCKNTMKFALFTSGVALTLSFV 382
Cdd:cd17463  217 SCSEALITTGFATFLPKFIENQFGQTSSFAAILGGLVLIPGAAIGQILGGIIVSKFKLKCKNMIKFAIITTTVSLLLLSV 296

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 383 FMYAKCENEPFAGVSESYNGTGELGNLIAPCNANCNCSRSYYYPVCG-DGVQYFSPCFAGCSNPVAHRKPKVYYNCSCIE 461
Cdd:cd17463  297 FIFAKCGNDPFAGVSETYNGTGKIGNLTAPCNANCSCLSSFYYPVCGaDGVQYFSPCFAGCTNENLHDKKKVYYNCSCIG 376

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767935830 462 RKTEITSTAETFGFEAKagKCETHCAKLPIFLCIFFIVIIFTFMAGTPITVSILR 516
Cdd:cd17463  377 NFTEEFSANTTKCEEGK--KCETTCKNLPIFLCFFFFVVIFTFMTSTPITVAILR 429
 
Name Accession Description Interval E-value
MFS_SLCO4C_OATP4C cd17463
Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of ...
 143-516 0e+00

Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4C (SLCO4C), also called Organic anion-transporting polypeptide 4C (OATP4C), subfamily has one mammalian member, OATP4C1 (encoded by SLCO4C1). It is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. It is the only OATP expressed at the basolateral side of proximal tubular cells in human kidney and it mediates the excretion of uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs) and cause further progression of renal damage and cardiovascular diseases. Overexpression of human SLCO4C1 in rat kidney promotes the renal excretion of uremic toxins and reduces hypertension, cardiomegaly, and renal inflammation in renal failure. The SLCO4C/OATP4C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341021 [Multi-domain]  Cd Length: 429  Bit Score: 546.65  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 143 VFILGQLLLGAGGTPLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYIDVAMGESTDVTEDDPRW 222
Cdd:cd17463   93 VFILGQLLLGVGGTPLYTLGTAYIDDSVPTHKSSLYIGIGYGMSVLGPAIGYLLGGQLLNIYIDVNKGQSVDLTEEDPRW 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 223 LGAWWIGFLLSWIFAWSLIIPFSCFPKHLPGtaeiqagktsqahqsnsnadvkfgksikdfpaalknLMKNAVFMCLVLS 302
Cdd:cd17463  173 LGAWWIGFLMCWLIAWCLIAPFSCFPKHLPG------------------------------------LLKNPVFMCLTIS 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 303 TSSEALITTGFATFLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGFLVSKFRMTCKNTMKFALFTSGVALTLSFV 382
Cdd:cd17463  217 SCSEALITTGFATFLPKFIENQFGQTSSFAAILGGLVLIPGAAIGQILGGIIVSKFKLKCKNMIKFAIITTTVSLLLLSV 296

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 383 FMYAKCENEPFAGVSESYNGTGELGNLIAPCNANCNCSRSYYYPVCG-DGVQYFSPCFAGCSNPVAHRKPKVYYNCSCIE 461
Cdd:cd17463  297 FIFAKCGNDPFAGVSETYNGTGKIGNLTAPCNANCSCLSSFYYPVCGaDGVQYFSPCFAGCTNENLHDKKKVYYNCSCIG 376

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767935830 462 RKTEITSTAETFGFEAKagKCETHCAKLPIFLCIFFIVIIFTFMAGTPITVSILR 516
Cdd:cd17463  377 NFTEEFSANTTKCEEGK--KCETTCKNLPIFLCFFFFVVIFTFMTSTPITVAILR 429
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
 156-576 2.61e-174

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 505.97  E-value: 2.61e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830  156 TPLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYIDVAMGeSTDVTEDDPRWLGAWWIGFLLSWI 235
Cdd:pfam03137 103 TPIYTLGISYIDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYVDIGKV-SITLTPKDPRWVGAWWLGFLIAGL 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830  236 FAWSLIIPFSCFPKHLPGTAEIQAGKTSQAHQSNSNADVK------FGKSIKDFPAALKNLMKNAVFMCLVLSTSSEALI 309
Cdd:pfam03137 182 LLLLTAIPFFFFPKSLPGAAKRRAKKKKEPHSQDIADLKKtkslkkLGPSLKDFPKALKRLLKNPVYMLLTLASVFEFLL 261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830  310 TTGFATFLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGFLVSKFRMTCKNTMKFALFTSGVALTLSFVFMYAKCE 389
Cdd:pfam03137 262 IAGYATFLPKYIETQFGLSASTANLLTGVVAIPGAALGILLGGLIIKKFKLSAKGLAKFNVITSLVSLLLSLLLFFLGCP 341

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830  390 NEPFAGVSESYNGTGEL-GNLIAPCNANCNCSRSYYYPVCGDGVQYFSPCFAGCSNPVAHRKPKVYYNCSCIerkTEITS 468
Cdd:pfam03137 342 NSPVAGITVPYGGTQQLsGNLTSSCNSDCSCSTSAYSPVCGSDGGYTSPCPCGAGCSSSSGAGKSTYICNCC---CSCGS 418

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830  469 TAETFGFEAKAGKCETHCA-KLPIFLCIFFIVIIFTFMAGTPITVSILRCVNHRQRSLALGIQFMVLRLLGTIPGPIIFG 547
Cdd:pfam03137 419 QDSGGNGSATPGKCPSDCSnKLPPFLALLFLASFFSSLSRTPGTLVILRCVPPEDKSFALGLQFLILRLLGFIPGPILFG 498

                         410       420
                  ....*....|....*....|....*....
gi 767935830  548 FTIDSTCILWDiNDCGIKGACWIYDNIKM 576
Cdd:pfam03137 499 ALIDSTCLLWG-KTCGGRGNCWLYDNDKL 526
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
 156-603 8.58e-102

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 322.84  E-value: 8.58e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830  156 TPLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYIDVAMGESTDV--TEDDPRWLGAWWIGFLLS 233
Cdd:TIGR00805 186 TPIFPLGISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGSFCLQIYVDTGSVNTEDLiiTPTDPRWIGAWWIGFLVC 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830  234 WIFAWSLIIPFSCFPKHLPGTA---EIQAGKTSQAHQSNSNADVKFGKSIKDFPAALKNLMKNAVFMCLVLSTSSEALIT 310
Cdd:TIGR00805 266 GFVALLTSIPLFFFPKTLPKEGkrvNVDVHEAEKLEKSRGEDRKKNSGITKDFPKFIKRLLCNKIYMLVILAQVIDVLAF 345

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830  311 TGFATFLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGFLVSKFRMTCKNTMKFA--LFTSGVALTLSFVFMYakC 388
Cdd:TIGR00805 346 NGYITFLPKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFKLNVKKAAYFAicLSTLEYLLYSPKFLIT--C 423

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830  389 ENEPFAGVSESYNGTGELGNLIAPCNANCNCSRSYYYPVCGD-GVQYFSPCFAGCSNPVAHRKPKVYYNCSCIERKTeit 467
Cdd:TIGR00805 424 ESAPVAGVNNPSNDQPLYVENRTDCNRQCSCDSSIWDPVCGDnGLAYLSPCHAGCRMSVGTGSNMVFTNCSCIQTPG--- 500

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830  468 staetfGFEAKAGKCETHCA-KLPIFLCIFFIVIIFTFMAGTPITVSILRCVNHRQRSLALGIQFMVLRLLGTIPGPIIF 546
Cdd:TIGR00805 501 ------NSSAKKGLCDPPCAtSLQYFLILFIPLSFIYFITAVPGYMVLLRCVKSEERSLGLGLQWFCIRVFGTIPAPILF 574

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767935830  547 GFTIDSTCILWDINDCGIKGACWIYDNIKMAHMLVAISVTCKVITMFFNGFAIFLYK 603
Cdd:TIGR00805 575 GALIDVTCLHWQTLKCGASGACRMYDNDNLRVIYLGLTIALRGSSLLPLFFILILAR 631
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
158-379 1.03e-10

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 63.45  E-value: 1.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 158 LYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYidvamgestdvtedDPRWlgAWWIG---FLLSW 234
Cdd:COG2814  115 LFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF--------------GWRW--VFLVNavlALLAL 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 235 IFAWsliipfscfpKHLPGTAEIQAGKtsqahqsnsnadvkfgksikdFPAALKNLMKNAVFMCLVLSTSSEALITTGFA 314
Cdd:COG2814  179 LLLL----------RLLPESRPAARAR---------------------LRGSLRELLRRPRLLLLLLLAFLLGFGFFALF 227

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767935830 315 TFLPKFIENQFGLTSSFAATLGGAVLIpGAALGQILGGFLVSKFRMtcKNTMKFALFTSGVALTL 379
Cdd:COG2814  228 TYLPLYLQEVLGLSASAAGLLLALFGL-GGVLGALLAGRLADRFGR--RRLLLIGLLLLALGLLL 289
 
Name Accession Description Interval E-value
MFS_SLCO4C_OATP4C cd17463
Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of ...
 143-516 0e+00

Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4C (SLCO4C), also called Organic anion-transporting polypeptide 4C (OATP4C), subfamily has one mammalian member, OATP4C1 (encoded by SLCO4C1). It is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. It is the only OATP expressed at the basolateral side of proximal tubular cells in human kidney and it mediates the excretion of uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs) and cause further progression of renal damage and cardiovascular diseases. Overexpression of human SLCO4C1 in rat kidney promotes the renal excretion of uremic toxins and reduces hypertension, cardiomegaly, and renal inflammation in renal failure. The SLCO4C/OATP4C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341021 [Multi-domain]  Cd Length: 429  Bit Score: 546.65  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 143 VFILGQLLLGAGGTPLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYIDVAMGESTDVTEDDPRW 222
Cdd:cd17463   93 VFILGQLLLGVGGTPLYTLGTAYIDDSVPTHKSSLYIGIGYGMSVLGPAIGYLLGGQLLNIYIDVNKGQSVDLTEEDPRW 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 223 LGAWWIGFLLSWIFAWSLIIPFSCFPKHLPGtaeiqagktsqahqsnsnadvkfgksikdfpaalknLMKNAVFMCLVLS 302
Cdd:cd17463  173 LGAWWIGFLMCWLIAWCLIAPFSCFPKHLPG------------------------------------LLKNPVFMCLTIS 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 303 TSSEALITTGFATFLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGFLVSKFRMTCKNTMKFALFTSGVALTLSFV 382
Cdd:cd17463  217 SCSEALITTGFATFLPKFIENQFGQTSSFAAILGGLVLIPGAAIGQILGGIIVSKFKLKCKNMIKFAIITTTVSLLLLSV 296

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 383 FMYAKCENEPFAGVSESYNGTGELGNLIAPCNANCNCSRSYYYPVCG-DGVQYFSPCFAGCSNPVAHRKPKVYYNCSCIE 461
Cdd:cd17463  297 FIFAKCGNDPFAGVSETYNGTGKIGNLTAPCNANCSCLSSFYYPVCGaDGVQYFSPCFAGCTNENLHDKKKVYYNCSCIG 376

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767935830 462 RKTEITSTAETFGFEAKagKCETHCAKLPIFLCIFFIVIIFTFMAGTPITVSILR 516
Cdd:cd17463  377 NFTEEFSANTTKCEEGK--KCETTCKNLPIFLCFFFFVVIFTFMTSTPITVAILR 429
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
 156-576 2.61e-174

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 505.97  E-value: 2.61e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830  156 TPLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYIDVAMGeSTDVTEDDPRWLGAWWIGFLLSWI 235
Cdd:pfam03137 103 TPIYTLGISYIDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYVDIGKV-SITLTPKDPRWVGAWWLGFLIAGL 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830  236 FAWSLIIPFSCFPKHLPGTAEIQAGKTSQAHQSNSNADVK------FGKSIKDFPAALKNLMKNAVFMCLVLSTSSEALI 309
Cdd:pfam03137 182 LLLLTAIPFFFFPKSLPGAAKRRAKKKKEPHSQDIADLKKtkslkkLGPSLKDFPKALKRLLKNPVYMLLTLASVFEFLL 261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830  310 TTGFATFLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGFLVSKFRMTCKNTMKFALFTSGVALTLSFVFMYAKCE 389
Cdd:pfam03137 262 IAGYATFLPKYIETQFGLSASTANLLTGVVAIPGAALGILLGGLIIKKFKLSAKGLAKFNVITSLVSLLLSLLLFFLGCP 341

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830  390 NEPFAGVSESYNGTGEL-GNLIAPCNANCNCSRSYYYPVCGDGVQYFSPCFAGCSNPVAHRKPKVYYNCSCIerkTEITS 468
Cdd:pfam03137 342 NSPVAGITVPYGGTQQLsGNLTSSCNSDCSCSTSAYSPVCGSDGGYTSPCPCGAGCSSSSGAGKSTYICNCC---CSCGS 418

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830  469 TAETFGFEAKAGKCETHCA-KLPIFLCIFFIVIIFTFMAGTPITVSILRCVNHRQRSLALGIQFMVLRLLGTIPGPIIFG 547
Cdd:pfam03137 419 QDSGGNGSATPGKCPSDCSnKLPPFLALLFLASFFSSLSRTPGTLVILRCVPPEDKSFALGLQFLILRLLGFIPGPILFG 498

                         410       420
                  ....*....|....*....|....*....
gi 767935830  548 FTIDSTCILWDiNDCGIKGACWIYDNIKM 576
Cdd:pfam03137 499 ALIDSTCLLWG-KTCGGRGNCWLYDNDKL 526
MFS_SLCO4_OATP4 cd17403
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...
 156-516 4.92e-132

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340961 [Multi-domain]  Cd Length: 420  Bit Score: 393.93  E-value: 4.92e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 156 TPLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYIDVAMGES-TDVTEDDPRWLGAWWIGFLLSW 234
Cdd:cd17403  106 TPLYTLGVTYLDENVSTKMSPLYIGIFYAMAILGPAIGYVLGGFLLNLYTDIDQVDSeLGLTPDDPRWVGAWWLGFLISG 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 235 IFAWSLIIPFSCFPKhlpgtaeiqagktsqahqsnsnadvkfgksikdfpaalknlmknaVFMCLVLSTSSEALITTGFA 314
Cdd:cd17403  186 ALALIIAFPLLGFPP---------------------------------------------TFMFLNLAGASEGMLLAGFA 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 315 TFLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGFLVSKFRMTCKNTMKFALFTSGVALTLSFVFMyAKCENEPFA 394
Cdd:cd17403  221 TFLPKLIESQFSLSASLAALLVGVVVVPGGILGTFLGGLIVKKLKLKCKGILKFCIVCSIVAFLFSFILL-IYCPNAPFA 299

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 395 GVSESYNGTGELG--NLIAPCNANCNCSRSYYYPVCG-DGVQYFSPCFAGCSNPVAHRKPKVYYNCSCIERKTEITSTAE 471
Cdd:cd17403  300 GVTVPYGNSPLEGtsNLTSTCNADCHCSEDFYDPVCGsDGVTYYSPCHAGCTTSHGDDGQKVYSNCSCIQSNSSKTSTAA 379

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 767935830 472 TFgfeaKAGKCETHCAKLPIFLCIFFIVIIFTFMAGTPITVSILR 516
Cdd:cd17403  380 TG----KACPCETCCQKLYLFLAVFFLLIVFTFMSSTPALSATLR 420
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
 156-603 8.58e-102

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 322.84  E-value: 8.58e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830  156 TPLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYIDVAMGESTDV--TEDDPRWLGAWWIGFLLS 233
Cdd:TIGR00805 186 TPIFPLGISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGSFCLQIYVDTGSVNTEDLiiTPTDPRWIGAWWIGFLVC 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830  234 WIFAWSLIIPFSCFPKHLPGTA---EIQAGKTSQAHQSNSNADVKFGKSIKDFPAALKNLMKNAVFMCLVLSTSSEALIT 310
Cdd:TIGR00805 266 GFVALLTSIPLFFFPKTLPKEGkrvNVDVHEAEKLEKSRGEDRKKNSGITKDFPKFIKRLLCNKIYMLVILAQVIDVLAF 345

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830  311 TGFATFLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGFLVSKFRMTCKNTMKFA--LFTSGVALTLSFVFMYakC 388
Cdd:TIGR00805 346 NGYITFLPKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFKLNVKKAAYFAicLSTLEYLLYSPKFLIT--C 423

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830  389 ENEPFAGVSESYNGTGELGNLIAPCNANCNCSRSYYYPVCGD-GVQYFSPCFAGCSNPVAHRKPKVYYNCSCIERKTeit 467
Cdd:TIGR00805 424 ESAPVAGVNNPSNDQPLYVENRTDCNRQCSCDSSIWDPVCGDnGLAYLSPCHAGCRMSVGTGSNMVFTNCSCIQTPG--- 500

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830  468 staetfGFEAKAGKCETHCA-KLPIFLCIFFIVIIFTFMAGTPITVSILRCVNHRQRSLALGIQFMVLRLLGTIPGPIIF 546
Cdd:TIGR00805 501 ------NSSAKKGLCDPPCAtSLQYFLILFIPLSFIYFITAVPGYMVLLRCVKSEERSLGLGLQWFCIRVFGTIPAPILF 574

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767935830  547 GFTIDSTCILWDINDCGIKGACWIYDNIKMAHMLVAISVTCKVITMFFNGFAIFLYK 603
Cdd:TIGR00805 575 GALIDVTCLHWQTLKCGASGACRMYDNDNLRVIYLGLTIALRGSSLLPLFFILILAR 631
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
 156-516 1.73e-101

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 314.95  E-value: 1.73e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 156 TPLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYIDVAMgESTDVTEDDPRWLGAWWIGFLLSWI 235
Cdd:cd17336  103 SPLYTLGITYIDDNVSKKNSPLYIGILYAMRVLGPALGFLLGSFLLRIYVDFSR-VPLGITPDDPRWIGAWWLGFLILGI 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 236 FAWSLIIPFSCFPKhlpgtaeiqagktsqahqsnsnadvkfgksikdfpaalknlmknaVFMCLVLSTSSEALITTGFAT 315
Cdd:cd17336  182 LLLIVSIPLFFFPP---------------------------------------------IFILLLLAIVFESFAISGFST 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 316 FLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGFLVSKFRMTCKNTMKFALFTSGVALTLSFVFMYAKCENEPFAG 395
Cdd:cd17336  217 FLPKYLETQFRLSASLASLLTGLILVPGAALGILLGGLIIKKFKLTARGLAKFVLILSLLSVILYISLFFLGCDNPPIAG 296

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 396 VSESYNGTGElgNLIAPCNANCNCSRSYYYPVCG-DGVQYFSPCFAGCSNPVAHRKPKVYYNCSCIErkteiTSTAETFG 474
Cdd:cd17336  297 VTTPYGSSSS--PITSSCNSDCNCSDSSFSPVCGsDGITYFSPCHAGCTSSDAGNGTKTYSNCSCIN-----SGTATSSG 369

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 767935830 475 FEAKAGKCETHCAKLPIFLCIFFIVIIFTFMAGTPITVSILR 516
Cdd:cd17336  370 CPPDCSVAPNCCSKLIPFLAVLFLSSFLLSLSIVPSTMITLR 411
MFS_SLCO6_OATP6 cd17405
Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of ...
 157-516 2.36e-88

Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 6 (SLCO6) or Organic anion transporting polypeptide 6 (OATP6) family contains only one subfamily, OATP6A, which contains only one human member OATP6A1 (encoded by SLCO6A1). The OATP6 family is the most diverged of the OATPs. OATP6A1 is also called cancer/testis antigen 48 (CT48) or gonad-specific transporter. It is strongly expressed only in normal testis, and weakly in spleen, brain, fetal brain, and placenta. It is found in tumor samples (lung, bladder, and esophageal) and cancer cell lines (lung), and may be of potential use as a target for therapy for a variety of tumor types. The SLCO6/OATP6 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340963 [Multi-domain]  Cd Length: 428  Bit Score: 281.35  E-value: 2.36e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 157 PLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYIDVAmGESTDVTEDDPRWLGAWWIGFLLSWIF 236
Cdd:cd17405  106 PIYILGITFIFDNIPTSSAGIYLGIAHSAYLIGYLLGYVGGLPNFQPPPNEK-SVEIEVNKVYQLWQSGWWKTFLIAAAI 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 237 AWSLIIPFSCFPKHLPGtaeiqagktsqahqsnsnadvkfgksikdfpaalknLMKNAVFMCLVLSTSSEALITTGFATF 316
Cdd:cd17405  185 AWCTSFPLVCFPTSLPG------------------------------------LLKNPLLLCQAICKATEYLTFIGALEF 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 317 LPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGFLVSKFRMTCKNTMKFALFTSGVALTLSFVFMYAKCENEPFAGV 396
Cdd:cd17405  229 LPHYLENQFLLTPGIASLLTGAFLIPGGAIGHFLGGLIVSRLEMSCKNKMRFILVTSVISLGLFVLIFFVECQTVTFAGI 308

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 397 SESYNGTGELGNLIAPCNANCNCSRSYYYPVCG-DGVQYFSPCFAGCSNPVAHRKPKVYYNCSCIeRKTEITSTAETFGF 475
Cdd:cd17405  309 NEDYDGYGQLGNLTAPCNEYCDCTSSLYTSICGrDEIEYFSPCFAGCKASKVSNTEKTYYNCSCI-KEGLAAADDEGDFI 387

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 767935830 476 EAKAGKCETHCAKLPIFLCIFFIVIIFTFMAGTPITVSILR 516
Cdd:cd17405  388 DAIAGKCDSKCYKLPLFFAFYFSATVFSNMCSIPIILIILR 428
MFS_SLCO5_OATP5 cd17404
Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ...
 156-490 9.93e-81

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340962 [Multi-domain]  Cd Length: 425  Bit Score: 261.52  E-value: 9.93e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 156 TPLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYIDvAMGESTDVTEDDPRWLGAWWIGFLLSWI 235
Cdd:cd17404  103 TPIFTLGTTYLDDHVKKESSSLYLAIMYVMGALGPAAGFLLGGLLINFYVD-PLSTPPDISPGDPRWIGAWWGGFLLCGI 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 236 FAWSLIIPFSCFPKhlpgtaeiqagktsqahqsnsnadvkfgksikdfpaalknlmknAVFMCLVLSTSSEALITTGFAT 315
Cdd:cd17404  182 ALLLVAFPFFTFPK--------------------------------------------MTFLVVSLGYCMELAIVSGFIT 217

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 316 FLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGFLVSKFRMTCKNTMKFALFTSGVALTLSFVFMYAKCENEPFAG 395
Cdd:cd17404  218 FLPKYLETQFGIPASNANIFTGVIAVPGAGIGIVLGGYILKRFKLGPKGAAKLALICNFLSLLLFLTLFFLGCESIKLAG 297

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 396 VSESYN-----GTGELGNLIAPCNANCNCSRSYYYPVCG-DGVQYFSPCFAGCSNPVAH-RKPKVYYNCSCIERKTEITS 468
Cdd:cd17404  298 ITIPYTtgpslSSTHGRNLTSECNVNCGCSINEYEPVCGsDGITYFSPCLAGCTSVGNTsTGIRNYTNCACLQSRSSISP 377

                        330       340
                 ....*....|....*....|..
gi 767935830 469 TAETFGFEAKAGKCETHCAKLP 490
Cdd:cd17404  378 PTVGQGSQLQAGPCSRTCNTLI 399
MFS_SLCO4A_OATP4A cd17462
Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of ...
 156-490 2.45e-77

Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4A (SLCO4A), also called Organic anion-transporting polypeptide 4A (OATP4A), subfamily has one mammalian member, OATP4A1 (encoded by SLCO4A1). It is ubiquitously expressed and it mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4A1 is the most abundantly expressed transporter colorectal cancer (CRC) and its role in the transport of estrone sulfate, which is used in hormone replacement therapy (HRT), affects the outcome of the treatment. The SLCO4A/OATP4A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341020 [Multi-domain]  Cd Length: 427  Bit Score: 252.83  E-value: 2.45e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 156 TPLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYIDvaMGESTDVTEDDPRWLGAWWIGFLLSWI 235
Cdd:cd17462  106 TPLYTLGVTYLDENVKSNYSPVYIGIFYTAAIVGPAAGYLLGGFFLNIYTE--IGRQTELTPENPLWVGAWWIGFLGAGA 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 236 FAWSLIIPFSCFPKHLPGtaeiqagktsqahqsnsnadvkfgksikdfpaalknLMKNAVFMCLVLSTSSEALITTGFAT 315
Cdd:cd17462  184 AALLIALPILGYPRQLPG------------------------------------LLKNPTFIFLCLAGATEATLIAGMST 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 316 FLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGFLVSKFRMTCKNTMKFALFTSGVALTLSFVFMyAKCENEPFAG 395
Cdd:cd17462  228 FGPKFLESQFSLSASEAATLFGYLVVPAGGGGTFLGGFIVNKLKLRCSGIIKFCLICTVVSLLAIFIFS-LHCPNVPMAG 306

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 396 VSESYNGT---GELGNLIAPCNANCNCSRSYYYPVCG-DGVQYFSPCFAGCSNPVAH--RKPKVYYNCSCIERkteitst 469
Cdd:cd17462  307 VTASYRGSvlpEGSLNLTALCNADCRCLEEIYSPVCGaDGLMYYSPCHAGCSEAYSDirNGQKVYQDCSCVAG------- 379

                        330       340
                 ....*....|....*....|..
gi 767935830 470 AETFGF-EAKAGKCETHCAKLP 490
Cdd:cd17462  380 NLSVGFgEASAGKCTSNCNHMP 401
MFS_SLCO1C_OATP1C cd17459
Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of ...
 156-517 3.79e-63

Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1C (SLCO1C), also called Organic anion-transporting polypeptide 1C (OATP1C), subfamily contains one mammalian member, OATP1C1 (encoded by SLCO1C1), which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine), as well as organic anions such as 17-beta-glucuronosyl estradiol, estrone-3-sulfate, and sulfobromophthalein (BSP), which are transported with much lower efficiency. The SLCO1C/OATP1C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341017 [Multi-domain]  Cd Length: 498  Bit Score: 216.94  E-value: 3.79e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 156 TPLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYIDVAMG--ESTDVTEDDPRWLGAWWIGFLLS 233
Cdd:cd17459  160 TPVQPLGISYIDDFAKEENAAFYIGCVQTIAIIGPVFGFLLGSLCAKLYVDIGFVnlDSITITPKDARWVGAWWLGYLIA 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 234 WIFAWSLIIPFSCFPKHLPgtaeiqagktsqahqsnsnadvkfgksiKDFPAALKNLMKNAVFMCLVLSTSSEALITTGF 313
Cdd:cd17459  240 GVITLLSAVPFWFLPKSLP----------------------------KDFLPSLKNLLGNPVYFLYLCTSILQFNSLIGM 291

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 314 ATFLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGFLVSKFRMTCKNTMKFALFTSGVALTLSFVFMYAKCENEPF 393
Cdd:cd17459  292 VTYKPKYIEQQYGQSASKANFLIGLINIPAVAIGIFSGGLLMKKFKLSVIGAAKLSFGTSFFGYLLLLSFFAMGCENSDV 371

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 394 AGVSESYNGTGEL----GNLIAPCNANCNCSRSYYYPVCGD-GVQYFSPCFAGCSNPVAHRKPKVYYNCSCIErkteiTS 468
Cdd:cd17459  372 AGLTVSYNGTKQVsyadRSLFSQCNADCKCSQKDWDPVCGEnGITYVSPCLAGCKASNGSGKNTVFHNCSCIG-----IP 446

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767935830 469 TAETFGFEAKAGKCE--THCAKL-PIFLCIFFIVIIFTFMAGTPITVSILRC 517
Cdd:cd17459  447 SSASGSSSAILGQCPkgNACARMfLYFLAISVISSFTLSLGGTPGYILLIRC 498
MFS_SLCO2A_OATP2A cd17461
Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of ...
 157-489 1.11e-59

Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2A (SLCO2A), also called Organic anion-transporting polypeptide 2A (OATP2A), subfamily has one mammalian member, OATP2A1 (encoded by SLCO2A1), which is also called prostaglandin transporter. It is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Mutations in SLCO2A1 can cause primary hypertrophic osteoarthropathy (PHO), a rare multi-organic disease characterized by digital clubbing, pachydermia and periosteal reaction. The SLCO2A/OATP2A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341019 [Multi-domain]  Cd Length: 474  Bit Score: 206.96  E-value: 1.11e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 157 PLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYIDV--AMGESTDVTEDDPRWLGAWWIGFLLSW 234
Cdd:cd17461  117 PIQPFGISYVDDFAEPSNSPLYIAILFAISVFGPAFGYLLGSVVLRIFVDIgrVNTATVELTPADPRWIGAWWLGLLISS 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 235 IFAWSLIIPFSCFPKHLPgtaeIQAGKTSQAHQSNSNADVKFGKS-----IKDFPAALKNLMKNAVFMCLVLSTSSEALI 309
Cdd:cd17461  197 GLLVLTSLPYFFFPREML----VGKKPSPEGDMLRKKEDEKKEEGslldfIKRFPKMFVKLLLNPLFMLLVLAQCTFSSV 272

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 310 TTGFATFLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGFLVSKFRMTCKNTMKFALFTSGVALTLSFVFMYAKCE 389
Cdd:cd17461  273 IAGLSTFLNKFLEKQYGASASYANFLIGAVNLPAAALGMLLGGIIMKRFGFSLRAIPRFSVVILSISIMLCVPLFFMGCS 352

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 390 NEPFAGVSESYNGTGElgNLIAPCNANCNCSRSYYYPVCG-DGVQYFSPCFAGCSNPV---AHRKPKVYYNCSCIerkte 465
Cdd:cd17461  353 TQDVAGVYPKTSNSSD--GPHLSCSANCSCPESAFNPVCGeNGIEYISPCHAGCTNSNmdsSTYRQQIYSNCSCI----- 425

                        330       340
                 ....*....|....*....|....
gi 767935830 466 itSTAETFGfEAKAGKCETHCAKL 489
Cdd:cd17461  426 --PDLSGEK-PAKTGSCPNSCSHL 446
MFS_SLCO2B_OATP2B cd17460
Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of ...
 157-489 1.15e-56

Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2B (SLCO2B), also called Organic anion-transporting polypeptide 2B (OATP2B), subfamily has one mammalian member, OATP2B1 (encoded by SLCO2B1). It mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. It also mediates the transport of endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). SLCO2B1 variations result in differential expression and uptake of DHEAS, which impacts subsequent resistance to androgen-deprivation therapy (ADT), the primary treatment of metastatic prostate cancer. The SLCO2B/OATP2B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341018 [Multi-domain]  Cd Length: 479  Bit Score: 199.23  E-value: 1.15e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 157 PLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYIDV--AMGESTDVTEDDPRWLGAWWIGFLLSW 234
Cdd:cd17460  113 PIQPFGISYIDDFASESNSPLYLGILFAVTVLGPGFGFMLGSAMLRFYVDIdkMSEDEISLEIGDPRWVGAWWLGFLIAA 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 235 IFAWSLIIPFSCFPKHLPGTA------EIQAGKTSQAHQSNSNAD---VKFGKSIKDFPAALKNLMKNAVFMCLVLSTSS 305
Cdd:cd17460  193 TLVALSAVPYFFFPREMPKEVvelqprEKKLAKTMLKKLKSLSDIlqnLSLLQFIKKFPRILLRTLRNPIYLLVVLAQVN 272

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 306 EALITTGFATFLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGFLVSKFRMTCKNTMKFALFTSGVALTLSFVFMY 385
Cdd:cd17460  273 LSAMVAGLATFMGKFLERQFSITASFANLMIGGLNIPSAMVGIVVGGVILKRLQLTVRGCGAMCVLGMLLCLFFALPLLF 352

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 386 AKCENEPFAGVSESYNgTGELGNLIAPCNANCNCSRSYYYPVCG-DGVQYFSPCFAGCSN---PVAHRKPKVYYNCSCIe 461
Cdd:cd17460  353 IGCSTQKIAGITHRTS-SSPGLELSSQCSEACSCPPEAFNPVCGsDGVEYISPCHAGCKSvnvQALDNSVVNYTDCSCV- 430

                        330       340
                 ....*....|....*....|....*...
gi 767935830 462 rkteitSTAETFGFeAKAGKCETHCAKL 489
Cdd:cd17460  431 ------SEGGPVGA-ASPGTCGSGCSHL 451
MFS_SLCO1B_OATP1B cd17457
Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of ...
 156-482 2.84e-56

Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1B (SLCO1B), also called organic anion-transporting polypeptide 1B (OATP1B), subfamily is composed of two human proteins, OATP1B1 (encoded by SLCO1B1) and OATP1B3 (encoded by SLCO1B3), and one rodent member, OATP1B2 (encoded by Slco1b2). OATP1B1 and OATP1B3 are almost exclusively expressed on the basal side of hepatocytes in normal human organs. They both can accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). Loss-of-function mutations in both SLCO1B1 and SLCO1B3 genes result in the Rotor syndrome, a hereditary hyperbilirubinemia. The SLCO1B/OATP1B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341015 [Multi-domain]  Cd Length: 455  Bit Score: 197.37  E-value: 2.84e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 156 TPLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYIDVAMGE--STDVTEDDPRWLGAWWIGFLLS 233
Cdd:cd17457  123 TPIVPLGISYLDDFAKEENSPLYLACLHTIAMIGPMIGFTLGSLFAKLYVDIGFVDlsTIRITPQDSRWVGAWWLGFLVS 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 234 WIFAWSLIIPFsCFpkhLPGtaeiqagktsqahqsnsnadvkfgksikdFPAALKNLMKNAVFMCLVLSTSSEALITTGF 313
Cdd:cd17457  203 GLFSIISAIPF-FF---LPG-----------------------------FFQSLKSILTNRLYVMFVCLTLLQVSSFIGF 249

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 314 ATFLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGFLVSKFRMTCKNTMKFALFTSGVALTLSFVFMYAKCENEPF 393
Cdd:cd17457  250 FTYKPKYMEQQYGQSSSKANFLLGVITLPIFASGMFLGGYIMKKYKLNTVGAAKFACFTSVMALSFYLLYFFIGCENKSV 329

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 394 AGVSESYNG----TGELGNLIAPCNANCNCSRSYYYPVCG-DGVQYFSPCFAGCSNPVAHRKPKVYYNCSCIErkteiTS 468
Cdd:cd17457  330 AGITMTYDGnnpvTSHRDVILSYCNSDCNCDESQWDPVCGnNGITYISACLAGCKSSSGNGKPIVFHNCSCLE-----VT 404

                        330
                 ....*....|....
gi 767935830 469 TAETFGFEAKAGKC 482
Cdd:cd17457  405 GSQNRNYSAHLGEC 418
MFS_SLCO3_OATP3 cd17402
Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of ...
 156-482 1.51e-55

Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 3 (SLCO3) or Organic anion transporting polypeptide 3 (OATP3) family contains only one subfamily, OATP3A, which contains only one mammalian member OATP3A1 (encoded by SLCO3A1). It mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate, prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123, and vasopressin. SLCO3A1 has been identified as a Crohn's disease (CD)-associated gene, which mediates inflammatory processes in intestinal epithelial cells through NF-kappaB transcription activation, resulting in a higher incidence of bowel perforation in CD patients. The SLCO3/OATP3 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340960 [Multi-domain]  Cd Length: 444  Bit Score: 195.15  E-value: 1.51e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 156 TPLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYIDVAMGEST--DVTEDDPRWLGAWWIGFLL- 232
Cdd:cd17402  116 TPVQPLGVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSklDITPDDPRWIGAWWGGFLLc 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 233 SWIFAWSLIIPFScFPKHLpgtaeiqagktsqahqsnsnadvkfgKSIKDFPAALKNLMKNAVFMCLVLSTSSEALITTG 312
Cdd:cd17402  196 GALLFFSALLMFG-FPQSL--------------------------QQLRVIPKVTKHLLSNPVFTCIVLAACMEIAVVAG 248

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 313 FATFLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGFLVSKFRMTCKNTMKFALFTSGVALTLSFVFMYAKCENEP 392
Cdd:cd17402  249 FAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCDTGP 328

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 393 FAGVSESY---NGTGELGNLIAPCNANCNCSRSYYYPVCG-DGVQYFSPCFAGCSNpvahrkpKVYYNCSCIerkteitS 468
Cdd:cd17402  329 VAGVTVPYgndTAPGSSLDPYAPCNSNCECQTDSFSPVCGaDGITYLSACFAGCSS-------TNLSGCACL-------S 394

                        330
                 ....*....|....
gi 767935830 469 TAETFGFEAKAGKC 482
Cdd:cd17402  395 SVPAENATVVPGKC 408
MFS_SLCO1A_OATP1A cd17458
Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of ...
 156-460 1.98e-53

Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1A (SLCO1A), also called Organic anion-transporting polypeptide 1A (OATP1A), subfamily is composed of one human member OATP1A2 (encoded by SLCO1A2) and several rodent proteins encoded by the Slco1a1, Slco1a3, Slco1a4, Slco1a5, and Slco1a6 genes. OATP1A2, also known as human OATP-A or OATP1, shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). It is expressed in the brain, kidney, intestine, liver, lung, testes, and the eye (ciliary body). The SLCO1A/OATP1A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341016 [Multi-domain]  Cd Length: 527  Bit Score: 191.22  E-value: 1.98e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 156 TPLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYIDVAMGESTDVT--EDDPRWLGAWWIGFLLS 233
Cdd:cd17458  156 TPVMPLGISYIDDFSKKENSPFYIGCLHTATIVGPLLGLLLASFCAQLYVDLGSVNADDLTitPTDIRWVGAWWLGFLIC 235

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 234 WIFAWSLIIPFSCFPKHLP---GTAEIQAGKTS----QAHQSNSNADVKFGKSiKDFPAALKNLMKNAVFMCLVLSTSSE 306
Cdd:cd17458  236 AGVNFLAGLPFWFLPKSLPkegEENETEPSKTLtvelEENKGQETKQEMYEIA-KDFLPFLKSLFRNPIYMLFIIVTVLQ 314

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 307 ALITTGFATFLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGFLVSKFRMTCKNTMKFALFTSGVALTLSFVFMYA 386
Cdd:cd17458  315 FNAFSGMISFMPKYLEQQYGKSASDAIFLIGVYNLPIICLGYFFGGLYMKKFKINTYQAAHIGFWVSLLEYLLYFSAFWM 394

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767935830 387 KCENEPFAGVSESYNGTG----ELGNLIAPCNANCNCSRSYYYPVCGD-GVQYFSPCFAGCSNPVAHRKPKVYYNCSCI 460
Cdd:cd17458  395 GCDNSPVAGLTVSYEGIDqdsyYENTLLADCNRDCDCPLKVWDPVCGNnGLTYVSACLAGCKASVGTGKNMVFQNCSCV 473
MFS_SLCO1_OATP1 cd17400
Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of ...
 156-461 2.46e-49

Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1 (SLCO1) or Organic anion transporting polypeptide 1 (OATP1) family contains three subfamilies: OATP1A, OATP1B, and OATP1C. OATP1A contains one human member, OATP1A2, which shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). OATP1B contains two human proteins, OATP1B1 and OATP1B3, which can both accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). OATP1C contains one mammalian member, OATP1C1, which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine). The SLCO1/OATP1 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340958 [Multi-domain]  Cd Length: 436  Bit Score: 178.10  E-value: 2.46e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 156 TPLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYIDVAMGESTD--VTEDDPRWLGAWWIGFLLS 233
Cdd:cd17400  116 TPILPLGISYIDDFAKEENSPLYIGLVETGAIIGPIIGFLLGSLCAKVYVDIGFVNLDDiiITPTDTRWVGAWWLGFLIC 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 234 WIFAWSLIIPFSCFPkhlpgtaeiqagktsqahqsnsnadvkfgksikdfpaalknlmknAVFMCLVLSTSSEALITTGF 313
Cdd:cd17400  196 GGVSVLTAIPFFFLP---------------------------------------------PIYMLFILVSVIQFNSFVGM 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 314 ATFLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGFLVSKFRMTCKNTMKFALFTSGVALTLSFVFMYAKCENEPF 393
Cdd:cd17400  231 ITYMPKYLEQQYGQSSSDANFLMGIINIPPIAIGYFIGGLIMKKFKITVKGAAKIGCWLSVLEYLLYLLSFLMTCENSSV 310

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767935830 394 AGVSESYNGTGEL----GNLIAPCNANCNCSRSYYYPVCGD-GVQYFSPCFAGCSNPVAHRKPKVYYNCSCIE 461
Cdd:cd17400  311 AGLTTSYEGIPPVlyheNDIFSDCNSDCNCPEKIWEPVCGNnGITYLSACLAGCETSIGTGKNIVFYNCSCIQ 383
MFS_SLCO2_OATP2 cd17401
Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of ...
 157-489 1.03e-47

Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2 (SLCO2) or Organic anion transporting polypeptide 2 (OATP2) family contains two subfamilies: OATP2A and OATP2B, each containing one mammalian member, OATP2A1 and OATP2B1, respectively. OATP2A1 (encoded by SLCO2A1) is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. OATP2B1 (encoded by SLCO2B1) mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost, as well as endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). The SLCO2/OATP2 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340959 [Multi-domain]  Cd Length: 440  Bit Score: 173.49  E-value: 1.03e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 157 PLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYIDVA-MGES-TDVTEDDPRWLGAWWIGFLLSW 234
Cdd:cd17401  113 PIQPFGISYIDDFAEPSNSPLYLGILFAVTVFGPAFGYLLGSVMLRLYVDIGrMNTAaVNLVPGDPRWIGAWWLGFLIAA 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 235 IFAWSLIIPFSCFPKHlpgtaeiqagktsqahqsnsnadvkfgksIKDFPAALKNLMKNAVFMCLVLSTSSEALITTGFA 314
Cdd:cd17401  193 ALLVLTSFPYFFFPRF-----------------------------IKRFPCIFLRTLRNPIFLLVVLAQVTLSSMIAGLA 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 315 TFLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGFLVSKFRMTCKNTMKFALFTSGVALTLSFVFMYAKCENEPFA 394
Cdd:cd17401  244 TFLNKFLEKQFGTTASYANFLIGAVNLPSAALGILFGGVLMKRLVLSLQAIPAICTTIITISMIFCVPLFFIGCSTPTIA 323

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 395 GVseSYNGTGELGNLIAP-CNANCNCSRSYYYPVCG-DGVQYFSPCFAGCSN----PVAHRKPKVYYNCSCIERKteits 468
Cdd:cd17401  324 GV--YPPSSSSSIHPQSPaCRRDCSCPDSIFNPVCGdNGVEYLSPCHAGCSNinmsTSATSKQVIYTNCSCVTGG----- 396

                        330       340
                 ....*....|....*....|.
gi 767935830 469 taetfGFEAKAGKCETHCAKL 489
Cdd:cd17401  397 -----SASAKTGSCPSPCSHL 412
KAZAL_SLC21 cd01330
The kazal-type serine protease inhibitor domain has been detected in an extracellular loop ...
 411-461 3.33e-21

The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a member of the superfamily of kazal-like proteinase inhibitors and follistatin-like proteins.


Pssm-ID: 238650 [Multi-domain]  Cd Length: 54  Bit Score: 86.97  E-value: 3.33e-21
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767935830 411 APCNANCNCSRSYYYPVCG-DGVQYFSPCFAGCSNPVAHRKPKVYYNCSCIE 461
Cdd:cd01330    3 SSCNSNCSCSESAYSPVCGeNGITYFSPCHAGCTNSTGSGGSKIYTNCSCVG 54
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
158-379 1.03e-10

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 63.45  E-value: 1.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 158 LYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYidvamgestdvtedDPRWlgAWWIG---FLLSW 234
Cdd:COG2814  115 LFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF--------------GWRW--VFLVNavlALLAL 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 235 IFAWsliipfscfpKHLPGTAEIQAGKtsqahqsnsnadvkfgksikdFPAALKNLMKNAVFMCLVLSTSSEALITTGFA 314
Cdd:COG2814  179 LLLL----------RLLPESRPAARAR---------------------LRGSLRELLRRPRLLLLLLLAFLLGFGFFALF 227

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767935830 315 TFLPKFIENQFGLTSSFAATLGGAVLIpGAALGQILGGFLVSKFRMtcKNTMKFALFTSGVALTL 379
Cdd:COG2814  228 TYLPLYLQEVLGLSASAAGLLLALFGL-GGVLGALLAGRLADRFGR--RRLLLIGLLLLALGLLL 289
Kazal_2 pfam07648
Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...
 414-459 1.19e-09

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.


Pssm-ID: 400135  Cd Length: 50  Bit Score: 54.04  E-value: 1.19e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767935830  414 NANCNCSRSYYYPVCG-DGVQYFSPC---FAGCSNPVAHRKPKVYYNCSC 459
Cdd:pfam07648   1 NCNCQCPKTEYEPVCGsDGVTYPSPCalcAAGCKLGKEVKEEKVKYDGSC 50
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 156-386 1.79e-08

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 57.05  E-value: 1.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 156 TPLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYIDVamgestdvteddprWLGAWWIGFLLSWI 235
Cdd:cd06174   99 GLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFG--------------WRAVFLIAAALALL 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 236 FAwsliIPFSCFPKHLPGtaeiqagktsqaHQSNSNADVKFGKSIKDFPAALKNLMknavFMCLVLSTSSEALITTGFAT 315
Cdd:cd06174  165 AA----ILLLLVVPDPPE------------SARAKNEEASSKSVLKLLKRVLKNPG----LWLLLLAIFLVNLAYYSFST 224

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767935830 316 FLPKFIENQFGLTSSFAATLGGAVLIPGaALGQILGGFLVSKFRmtcknTMKFALFTSGVALTLSFVFMYA 386
Cdd:cd06174  225 LLPLFLLDLGGLSVAVAGLLLSLFGLAG-ALGSLLLGLLSDRLI-----GRKPLLLIGLLLMALGLALLLL 289
KAZAL_FS cd00104
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...
 419-459 1.10e-07

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the cognate enzyme as substrate. The reactive site peptide bond is a combining loop which has an identical conformation in all Kazal inhibitors and in all enzyme/inhibitor complexes. These Kazal domains (small hydrophobic core of alpha/beta structure with 3 to 4 disulfide bonds) often occur in tandem arrays. Similar domains are also present in follistatin (FS) and follistatin-like family members, which play an important role in tissue specific regulation. The FS domain consists of an N-terminal beta hairpin (FOLN/EGF-like domain) and a Kazal-like domain and has five disulfide bonds. Although the Kazal-like FS substructure is similar to Kazal proteinase inhibitors, no FS domain has yet been shown to be a proteinase inhibitor. Follistatin-like family members include SPARC, also known as, BM-40 or osteonectin, the Gallus gallus Flik protein, as well as, agrin which has a long array of FS domains. The kazal-type inhibitor domain has also been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The distant homolog, Ascidian trypsin inhibitor, is included in this CD.


Pssm-ID: 238052 [Multi-domain]  Cd Length: 41  Bit Score: 48.42  E-value: 1.10e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 767935830 419 CSRSYYyPVCG-DGVQYFSPCFAGCSNPVAHRKPKVYYNCSC 459
Cdd:cd00104    1 CPKEYD-PVCGsDGKTYSNECHLGCAACRSGRSITVAHNGPC 41
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
294-383 1.68e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 50.64  E-value: 1.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 294 AVFMCLVLSTSSEALITTGFATFLPKFIENQFGLTSSFAATLGGAVLIpGAALGQILGGFLVSKFRMTCKNTMKFALFTS 373
Cdd:COG2271  180 LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFL-AGIVGSLLGGWLSDRLGRRRKLVLAIGLLLA 258

                         90
                 ....*....|
gi 767935830 374 GVALTLSFVF 383
Cdd:COG2271  259 ALALLLLALL 268
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 280-394 2.04e-06

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 50.31  E-value: 2.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 280 IKDFPAALKNLMKNAVFMCLVLSTSSEALITTGFATFLPKFIENQFGLTSSFAATLG---GAVLIPGAALGQILGGFLVS 356
Cdd:cd17328  193 ATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGlifGAITCIAGVLGVLLGGILAD 272

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 767935830 357 KFRMTCKNTMKF-ALFTSGVALTLSFVFMYAKCENEPFA 394
Cdd:cd17328  273 RLRRKTPRADPLvCAVGLLAAAPFLFLALVLALSNLLLA 311
MFS_1 pfam07690
Major Facilitator Superfamily;
158-384 3.08e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 49.72  E-value: 3.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830  158 LYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYidvamgestdvteddpRWLGAWWIGFLLSWIFA 237
Cdd:pfam07690 102 LFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF----------------GWRAAFLILAILSLLAA 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830  238 WSLIIPfscfpkhlpgtaeiqagktsqAHQSNSNADVKFGKSIKDFPAALKNLMKNAVFMCLVLSTSSeALITTGFATFL 317
Cdd:pfam07690 166 VLLLLP---------------------RPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLF-GFAFFGLLTYL 223

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767935830  318 PKFIEnQFGLTSSFAATLGGAVLIpGAALGQILGGFLVSKFRmtcKNTMKFALFTSGVALTLSFVFM 384
Cdd:pfam07690 224 PLYQE-VLGLSALLAGLLLGLGGL-LGAIGRLLLGRLSDRLG---RRRRLLLALLLLILAALGLLLL 285
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
162-384 1.51e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 47.57  E-value: 1.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 162 GTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYidvamgestdvtedDPRWLGAWWIGFLLSWIFAWSLI 241
Cdd:COG2223  114 GIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF--------------GWRNAFLILGILLLVVAVLAWLF 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 242 IPFScfPKHLPGTAEiqagktsqahqsnsnadvkfgKSIKDFPAALKNlmKNAVFMCLVLSTSSEALIttGFATFLPKFI 321
Cdd:COG2223  180 LRDP--PAGAAAAAK---------------------ASLRDQLEALRD--PRFWLLSLLYFGTFGSFI--GFSSWLPPYL 232

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767935830 322 ENQFGLTSSFAATLGGAVLIPGaALGQILGGFLVSKFRMtcKNTMKFALFTSGVALTLSFVFM 384
Cdd:COG2223  233 VDQFGLSAATAGLLAALFALLG-ALGRPLGGWLSDRIGG--RRVLLIVFALMALGLLLLALAL 292
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 159-383 7.46e-05

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 45.26  E-value: 7.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 159 YTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTiyidvamgestdvteddprWLGaWWIGFLLSWIFAW 238
Cdd:cd17320  105 SVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLL-------------------FFG-WRAIFVFLALLGL 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 239 SLIIPFSCFpkhLPGTAEIQagktsqahqsnsnadvKFGKSIKDFPAALKNLMKNAVFMCLVLSTsseALITTGFATFL- 317
Cdd:cd17320  165 LLLLLVLLF---LPETLPEE----------------KRKPLLSSLLRAYKRVLKNRRFLGYALAL---GLSFAGLFAYLa 222

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767935830 318 --PKFIENQFGLTSS-FAatLGGAVLIPGAALGQILGGFLVSKFRMtcKNTMKFALFTSGVALTLSFVF 383
Cdd:cd17320  223 aaPFIYIEQLGLSPAqFG--LLFALNAIALILGSLLNGRLVRRFGP--RRLLRLGLLLLLAAALVLLLA 287
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 176-379 1.60e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 41.06  E-value: 1.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 176 SLYIGTGYAMSILGPAIG---YVLGGQLLTIYIDVamgestdvteddprwlgawwIGFLLSWIFAWSLIIPFscfpkhlp 252
Cdd:cd06173  131 ALNSLATQLARIIGPALGgllVALLGPGGAFAINA--------------------LSFLLSALLLLFIRRPP-------- 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 253 gtaeiqAGKTSQAHQSNSNADVKFGKSIKDFPAALKNLMKNAVFmclvlstsseALITTGFATFLPKFIENQFGLTSSFA 332
Cdd:cd06173  183 ------PAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALF----------ALLGGALTVLLPLLAKEVLGGGAAGY 246

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 767935830 333 ATLGGAvlipgAALGQILGGFLVSKF--RMTCKNTMKFALFTSGVALTL 379
Cdd:cd06173  247 GLLLAA-----FGVGALLGALLLGRLskRRRRGRLLLIGALLLGLALLV 290
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
295-386 3.43e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 40.24  E-value: 3.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 295 VFMCLVLSTSSEALITTGFATFLPkFIENQFGLTSSFAATLGGAVLIpGAALGQILGGFLVSKFRMtcKNTMKFALFTSG 374
Cdd:COG2271   11 ILALLFLAYFLNYLDRSNLSVAAP-PLQADLGLSAAQLGLLASAFFL-GYALGQIPAGLLADRFGR--RRVLAIGLLLWG 86

                         90
                 ....*....|....*..
gi 767935830 375 VALTL-----SFVFMYA 386
Cdd:COG2271   87 LATLLfgfatSFWQLLL 103
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 222-386 4.77e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 39.85  E-value: 4.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 222 WLGAWWIGFLLSWIFAWSLIIPFSCFPKHLPGTAEIQAGKTSQAHQsnsnadvkfgksikdfpAALKNLMKNAVFMcLVL 301
Cdd:cd17478  141 ALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSA-----------------RSTLKGVWRALLL-LLI 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 302 STSSEALITTGFATFLPKFIENQfGLTSSFAATLGGAVLIPGAAlGQILGGFLVSKF-RmtcKNTMKFALFTSGVALtls 380
Cdd:cd17478  203 IVFLRSWVLSSLTTFLPFYLVQR-GYSLVFAGLLLSLFLFAGAI-GTLIGGPLSDRFgR---RRVIIASLLLAAPFL--- 274


                 ....*.
gi 767935830 381 FVFMYA 386
Cdd:cd17478  275 LLFLLT 280
MFS_FLVCR_like cd17398
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ...
 188-386 4.98e-03

Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340956 [Multi-domain]  Cd Length: 406  Bit Score: 39.53  E-value: 4.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 188 LGPAIGYVLGGQLltiyidVAMGESTDVTEDDPRWLgAWWIGFLLSWIFAwSLIIPFSCFPKHLPGTAEIQAgktsqahQ 267
Cdd:cd17398  142 LGVALGFVLPPLL------VPNSENKDEIGKGLSIL-FYGVAGICTALFI-LVIIFFKEKPPIPPSRAQAAA-------Q 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 268 SNSNADVKFGKSIKdfpaalkNLMKNAVFMCLVLSTSSEALITTGFATFLPKFIENQFGlTSSFAATLGGAVLIPGAALG 347
Cdd:cd17398  207 ELRSEDQSYLGSLK-------RLFKNKGFLLLLITYGINTGVYYAISTLLNQMVLEYFP-NEEVNAGWIGLTLVIAGLVG 278

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 767935830 348 QILGGFLVSKFRmtckntmKFALFTSGVALtLSFVFMYA 386
Cdd:cd17398  279 SVVAGIWLDKTK-------KYKETTIIVYI-LSFIGMVA 309
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 160-379 6.17e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 39.48  E-value: 6.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 160 TLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYidvamgestdvteddprwlgAWWIGFLLSWIFAwS 239
Cdd:cd17325  103 PAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL--------------------GYRAPFLVCAALA-L 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 240 LIIPFSCFPKHlpgtaeiqagKTSQAHQSNSNADVKFGKSIKDFpaalknLMKNAVFMCLVLSTSSeALITTGFATFLPK 319
Cdd:cd17325  162 LALVLALLLLP----------EPRPPPNKRAVSAARLRSGLRLL------LRDRRLLALFLAIFVL-AFAFGALEPFLPL 224

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767935830 320 FIENQFGLTSSFAATLGGAVLIPgAALGQILGGFLVSKF-RmtcKNTMKFALFTSGVALTL 379
Cdd:cd17325  225 YAAELGGLSPAQIGLLFGAQGLA-SALSQPPAGKLSDRIgR---KPLILIGLLLSAVALLL 281
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 285-384 6.39e-03

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 39.07  E-value: 6.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 285 AALKNLMKNAVFMCLVLSTSSEALITTGFATFLPKFIENQfGLTSSFAATLggaVLIPGAA--LGQILGGFLVSKFRMTC 362
Cdd:cd17352  174 GLLLRLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSL-GIDESDAAFL---LSIIGISdiVGRILLGLLADKPRIGR 249

                         90       100
                 ....*....|....*....|..
gi 767935830 363 KNTMKFALFTSGVALTLSFVFM 384
Cdd:cd17352  250 LYLYIFTLLILGLSLLAFPLAT 271
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 296-386 8.86e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 38.74  E-value: 8.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 296 FMCLVLSTSSEALITTGFATFLPKFIENQFGLTSSFAATLGGAVLIpGAALGQILGGFLVSKFRMtcKNTMKFALFTSGV 375
Cdd:cd17316  179 TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISL-GALVGALIAGLLSDRIGR--KKTLVIGLILSGI 255

                         90
                 ....*....|.
gi 767935830 376 ALTLSFVFMYA 386
Cdd:cd17316  256 LALPLFYLLSG 266
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 299-385 9.59e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 38.56  E-value: 9.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935830 299 LVLSTSSEALITTGFATFLPkFIENQFGLTSSFAATLGGAVLIpGAALGQILGGFLVSKFRmtckntMKFALFTSGVALT 378
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLP-ALLQSFGLSASQLGLLFALFSL-GYALLQPLAGLLADRFG------RRPVLLLGLLLFA 72


                 ....*..
gi 767935830 379 LSFVFMY 385
Cdd:cd06174   73 LGALLFA 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH