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Conserved domains on  [gi|767936125|ref|XP_011541791|]
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lysine-specific demethylase 3B isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
cupin_RmlC-like super family cl40423
RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP ...
 1551-1656 4.61e-20

RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP (deoxythymidine diphosphates)-4-dehydrorhamnose 3,5-epimerase)-like cupins. RmlC is a dTDP-sugar isomerase involved in the synthesis of L-rhamnose, a saccharide required for the virulence of some pathogenic bacteria. Cupins are a functionally diverse superfamily originally discovered based on the highly conserved motif found in germin and germin-like proteins. This conserved motif forms a beta-barrel fold found in all of the cupins, giving rise to the name cupin ('cupa' is the Latin term for small barrel). The active site of members of this superfamily is generally located at the center of a conserved barrel and usually includes a metal ion. The different functional classes in this superfamily include single domain bacterial isomerases and epimerases involved in the modification of cell wall carbohydrates, two domain bicupins such as the desiccation-tolerant seed storage globulins, and multidomain nuclear transcription factors involved in legume root nodulation.


The actual alignment was detected with superfamily member pfam02373:

Pssm-ID: 477354  Cd Length: 114  Bit Score: 87.35  E-value: 4.61e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936125  1551 TKQRIHDGKEKPG-ALWHIYAAKDAEKIRELLRKVGEEqGQENP-PDHDPIHDQSWYLDQTLRKRLYEEyGVQGWAIVQF 1628
Cdd:pfam02373    9 STTPWHIEDQGLYsINYLHFGAPKVWYIIPPEYAEKFE-KVLSDhFGGEQPDDLLHLNTIISPKQLREN-GIPVYRFVQK 86

                           90       100
                   ....*....|....*....|....*...
gi 767936125  1629 LGDAVFIPAGAPHQVHNLYSCIKVAEDF 1656
Cdd:pfam02373   87 PGEFVFTFPGWYHQVFNLGFNIAEAVNF 114
JmjC smart00558
A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of ...
 1454-1526 5.86e-05

A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes (Clissold and Ponting, in press).


:

Pssm-ID: 214721  Cd Length: 58  Bit Score: 42.24  E-value: 5.86e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767936125   1454 FEDLMENLPLpeytkrdgRLNLASRLPSYFVRPDLGPKMYnaYGLItaedrrVGTTNLHLDVSDAVNVMVYVG 1526
Cdd:smart00558    1 QLWNLAKLPF--------KLNLLSDLPEDIPGPDVGPYLY--MGMA------GSTTPWHIDDYDLVNYLHQGA 57
PRK11901 super family cl36081
hypothetical protein; Reviewed
 623-709 8.94e-03

hypothetical protein; Reviewed


The actual alignment was detected with superfamily member PRK11901:

Pssm-ID: 237015 [Multi-domain]  Cd Length: 327  Bit Score: 40.44  E-value: 8.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936125  623 APSWPESHSSADSASLAKKkplfITTDSSKLVSGvlGSALTSGGPSLSAMGNGRSSSPTSSLTQPIEMPTLSSSPTEERP 702
Cdd:PRK11901   60 SPTEHESQQSSNNAGAEKN----IDLSGSSSLSS--GNQSSPSAANNTSDGHDASGVKNTAPPQDISAPPISPTPTQAAP 133


                  ....*...
gi 767936125  703 TVGP-GQQ 709
Cdd:PRK11901  134 PQTPnGQQ 141
 
Name Accession Description Interval E-value
JmjC pfam02373
JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain ...
 1551-1656 4.61e-20

JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyze a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalysing hydroxylation.


Pssm-ID: 396791  Cd Length: 114  Bit Score: 87.35  E-value: 4.61e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936125  1551 TKQRIHDGKEKPG-ALWHIYAAKDAEKIRELLRKVGEEqGQENP-PDHDPIHDQSWYLDQTLRKRLYEEyGVQGWAIVQF 1628
Cdd:pfam02373    9 STTPWHIEDQGLYsINYLHFGAPKVWYIIPPEYAEKFE-KVLSDhFGGEQPDDLLHLNTIISPKQLREN-GIPVYRFVQK 86

                           90       100
                   ....*....|....*....|....*...
gi 767936125  1629 LGDAVFIPAGAPHQVHNLYSCIKVAEDF 1656
Cdd:pfam02373   87 PGEFVFTFPGWYHQVFNLGFNIAEAVNF 114
JmjC smart00558
A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of ...
 1454-1526 5.86e-05

A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes (Clissold and Ponting, in press).


Pssm-ID: 214721  Cd Length: 58  Bit Score: 42.24  E-value: 5.86e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767936125   1454 FEDLMENLPLpeytkrdgRLNLASRLPSYFVRPDLGPKMYnaYGLItaedrrVGTTNLHLDVSDAVNVMVYVG 1526
Cdd:smart00558    1 QLWNLAKLPF--------KLNLLSDLPEDIPGPDVGPYLY--MGMA------GSTTPWHIDDYDLVNYLHQGA 57
cupin_Bh2720-like cd02223
Bacillus halodurans Bh2720 and related proteins, cupin domain; This family includes bacterial, ...
 1583-1648 7.17e-04

Bacillus halodurans Bh2720 and related proteins, cupin domain; This family includes bacterial, archaeal, and eukaryotic proteins similar to Bh2720, a Bacillus halodurans protein of unknown function with a cupin beta-barrel fold.


Pssm-ID: 380352 [Multi-domain]  Cd Length: 98  Bit Score: 40.61  E-value: 7.17e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767936125 1583 KVGEEQGQEnppdhdpIHDQSwylDQTLRkrlYEEyGvQGWAIV---QFL---GDAVFIPAGAPHQVHN-------LYS 1648
Cdd:cd02223    19 PPGEDIGLE-------VHDDV---DQFLR---IEE-G-EGKAIMggfESEvkdGDAIIVPAGTWHNVINtgneplkLYT 82
PRK11901 PRK11901
hypothetical protein; Reviewed
 623-709 8.94e-03

hypothetical protein; Reviewed


Pssm-ID: 237015 [Multi-domain]  Cd Length: 327  Bit Score: 40.44  E-value: 8.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936125  623 APSWPESHSSADSASLAKKkplfITTDSSKLVSGvlGSALTSGGPSLSAMGNGRSSSPTSSLTQPIEMPTLSSSPTEERP 702
Cdd:PRK11901   60 SPTEHESQQSSNNAGAEKN----IDLSGSSSLSS--GNQSSPSAANNTSDGHDASGVKNTAPPQDISAPPISPTPTQAAP 133


                  ....*...
gi 767936125  703 TVGP-GQQ 709
Cdd:PRK11901  134 PQTPnGQQ 141
 
Name Accession Description Interval E-value
JmjC pfam02373
JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain ...
 1551-1656 4.61e-20

JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyze a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalysing hydroxylation.


Pssm-ID: 396791  Cd Length: 114  Bit Score: 87.35  E-value: 4.61e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936125  1551 TKQRIHDGKEKPG-ALWHIYAAKDAEKIRELLRKVGEEqGQENP-PDHDPIHDQSWYLDQTLRKRLYEEyGVQGWAIVQF 1628
Cdd:pfam02373    9 STTPWHIEDQGLYsINYLHFGAPKVWYIIPPEYAEKFE-KVLSDhFGGEQPDDLLHLNTIISPKQLREN-GIPVYRFVQK 86

                           90       100
                   ....*....|....*....|....*...
gi 767936125  1629 LGDAVFIPAGAPHQVHNLYSCIKVAEDF 1656
Cdd:pfam02373   87 PGEFVFTFPGWYHQVFNLGFNIAEAVNF 114
JmjC smart00558
A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of ...
 1454-1526 5.86e-05

A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes (Clissold and Ponting, in press).


Pssm-ID: 214721  Cd Length: 58  Bit Score: 42.24  E-value: 5.86e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767936125   1454 FEDLMENLPLpeytkrdgRLNLASRLPSYFVRPDLGPKMYnaYGLItaedrrVGTTNLHLDVSDAVNVMVYVG 1526
Cdd:smart00558    1 QLWNLAKLPF--------KLNLLSDLPEDIPGPDVGPYLY--MGMA------GSTTPWHIDDYDLVNYLHQGA 57
cupin_Bh2720-like cd02223
Bacillus halodurans Bh2720 and related proteins, cupin domain; This family includes bacterial, ...
 1583-1648 7.17e-04

Bacillus halodurans Bh2720 and related proteins, cupin domain; This family includes bacterial, archaeal, and eukaryotic proteins similar to Bh2720, a Bacillus halodurans protein of unknown function with a cupin beta-barrel fold.


Pssm-ID: 380352 [Multi-domain]  Cd Length: 98  Bit Score: 40.61  E-value: 7.17e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767936125 1583 KVGEEQGQEnppdhdpIHDQSwylDQTLRkrlYEEyGvQGWAIV---QFL---GDAVFIPAGAPHQVHN-------LYS 1648
Cdd:cd02223    19 PPGEDIGLE-------VHDDV---DQFLR---IEE-G-EGKAIMggfESEvkdGDAIIVPAGTWHNVINtgneplkLYT 82
PRK11901 PRK11901
hypothetical protein; Reviewed
 623-709 8.94e-03

hypothetical protein; Reviewed


Pssm-ID: 237015 [Multi-domain]  Cd Length: 327  Bit Score: 40.44  E-value: 8.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936125  623 APSWPESHSSADSASLAKKkplfITTDSSKLVSGvlGSALTSGGPSLSAMGNGRSSSPTSSLTQPIEMPTLSSSPTEERP 702
Cdd:PRK11901   60 SPTEHESQQSSNNAGAEKN----IDLSGSSSLSS--GNQSSPSAANNTSDGHDASGVKNTAPPQDISAPPISPTPTQAAP 133


                  ....*...
gi 767936125  703 TVGP-GQQ 709
Cdd:PRK11901  134 PQTPnGQQ 141
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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