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Conserved domains on  [gi|767912187|ref|XP_011542389|]
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WD repeat-containing protein 64 isoform X3 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 284-538 2.36e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 98.18  E-value: 2.36e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912187 284 KLHNDWVMKIRYISALNCFGSCSLDSnhslvleSLK--RLEDNLPVREFsmpRGANTFCYCVKAN----VIVTGGDDKVI 357
Cdd:cd00200   48 KGHTGPVRDVAASADGTYLASGSSDK-------TIRlwDLETGECVRTL---TGHTSYVSSVAFSpdgrILSSSSRDKTI 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912187 358 RLWHpNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGgpgdmQIYSMIYDANHGM 437
Cdd:cd00200  118 KVWD-VETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG-----EVNSVAFSPDGEK 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912187 438 LITGSSVMDMYPLTRMIQDTKQVPHTHEREINVMLY--NKYFhqvLTICSE-SIIRVWELETGLQVYQIlepHGFNTEVT 514
Cdd:cd00200  192 LLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFspDGYL---LASGSEdGTIRVWDLRTGECVQTL---SGHTNSVT 265

                        250       260
                 ....*....|....*....|....
gi 767912187 515 SAAVDESGFLFATGAYNGTVRIWD 538
Cdd:cd00200  266 SLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 284-538 2.36e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.18  E-value: 2.36e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912187 284 KLHNDWVMKIRYISALNCFGSCSLDSnhslvleSLK--RLEDNLPVREFsmpRGANTFCYCVKAN----VIVTGGDDKVI 357
Cdd:cd00200   48 KGHTGPVRDVAASADGTYLASGSSDK-------TIRlwDLETGECVRTL---TGHTSYVSSVAFSpdgrILSSSSRDKTI 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912187 358 RLWHpNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGgpgdmQIYSMIYDANHGM 437
Cdd:cd00200  118 KVWD-VETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG-----EVNSVAFSPDGEK 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912187 438 LITGSSVMDMYPLTRMIQDTKQVPHTHEREINVMLY--NKYFhqvLTICSE-SIIRVWELETGLQVYQIlepHGFNTEVT 514
Cdd:cd00200  192 LLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFspDGYL---LASGSEdGTIRVWDLRTGECVQTL---SGHTNSVT 265

                        250       260
                 ....*....|....*....|....
gi 767912187 515 SAAVDESGFLFATGAYNGTVRIWD 538
Cdd:cd00200  266 SLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
348-554 2.47e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.51  E-value: 2.47e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912187 348 IVTGGDDKVIRLWHPNiSTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGGpgdmqIY 427
Cdd:COG2319  135 LASGSADGTVRLWDLA-TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA-----VR 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912187 428 SMIYDANHGMLITGSSvmDmypltRMIQ----DTKQVPHT---HEREINVMLYNKYFHQVLTICSESIIRVWELETGLQV 500
Cdd:COG2319  209 SVAFSPDGKLLASGSA--D-----GTVRlwdlATGKLLRTltgHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELL 281

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767912187 501 yQILEPHGFntEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDW 554
Cdd:COG2319  282 -RTLTGHSG--GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA 332
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 507-538 1.05e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.05e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767912187   507 HGFNTEVTSAAVDESGFLFATGAYNGTVRIWD 538
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 284-538 2.36e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.18  E-value: 2.36e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912187 284 KLHNDWVMKIRYISALNCFGSCSLDSnhslvleSLK--RLEDNLPVREFsmpRGANTFCYCVKAN----VIVTGGDDKVI 357
Cdd:cd00200   48 KGHTGPVRDVAASADGTYLASGSSDK-------TIRlwDLETGECVRTL---TGHTSYVSSVAFSpdgrILSSSSRDKTI 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912187 358 RLWHpNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGgpgdmQIYSMIYDANHGM 437
Cdd:cd00200  118 KVWD-VETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG-----EVNSVAFSPDGEK 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912187 438 LITGSSVMDMYPLTRMIQDTKQVPHTHEREINVMLY--NKYFhqvLTICSE-SIIRVWELETGLQVYQIlepHGFNTEVT 514
Cdd:cd00200  192 LLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFspDGYL---LASGSEdGTIRVWDLRTGECVQTL---SGHTNSVT 265

                        250       260
                 ....*....|....*....|....
gi 767912187 515 SAAVDESGFLFATGAYNGTVRIWD 538
Cdd:cd00200  266 SLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
348-554 2.47e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.51  E-value: 2.47e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912187 348 IVTGGDDKVIRLWHPNiSTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGGpgdmqIY 427
Cdd:COG2319  135 LASGSADGTVRLWDLA-TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA-----VR 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912187 428 SMIYDANHGMLITGSSvmDmypltRMIQ----DTKQVPHT---HEREINVMLYNKYFHQVLTICSESIIRVWELETGLQV 500
Cdd:COG2319  209 SVAFSPDGKLLASGSA--D-----GTVRlwdlATGKLLRTltgHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELL 281

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767912187 501 yQILEPHGFntEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDW 554
Cdd:COG2319  282 -RTLTGHSG--GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA 332
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 334-554 1.53e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.01  E-value: 1.53e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912187 334 RGANTFCYCVKA----NVIVTGGDDKVIRLWhpNIST-KPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTL 408
Cdd:cd00200    6 KGHTGGVTCVAFspdgKLLATGSGDGTIKVW--DLETgELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912187 409 SLLQVFHDSQGGpgdmqIYSMIYDANHGMLITGSSvmDMyplTRMIQDT-----KQVPHTHEREINVMLYNKYFHQVLTI 483
Cdd:cd00200   84 ECVRTLTGHTSY-----VSSVAFSPDGRILSSSSR--DK---TIKVWDVetgkcLTTLRGHTDWVNSVAFSPDGTFVASS 153

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767912187 484 CSESIIRVWELETGLQVYQIlepHGFNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDW 554
Cdd:cd00200  154 SQDGTIKLWDLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENG 221
WD40 COG2319
WD40 repeat [General function prediction only];
348-554 1.79e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.81  E-value: 1.79e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912187 348 IVTGGDDKVIRLWHPNiSTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGGpgdmqIY 427
Cdd:COG2319  177 LASGSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS-----VR 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912187 428 SMIYDANHGMLITGSSvmdmyplTRMIQ----DTKQVPHT---HEREINVMLYNKYFHQVLTICSESIIRVWELETGlQV 500
Cdd:COG2319  251 SVAFSPDGRLLASGSA-------DGTVRlwdlATGELLRTltgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG-KL 322

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767912187 501 YQILEPHgfNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDW 554
Cdd:COG2319  323 LRTLTGH--TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGA 374
WD40 COG2319
WD40 repeat [General function prediction only];
346-538 1.42e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.12  E-value: 1.42e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912187 346 NVIVTGGDDKVIRLWHPNiSTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGGpgdmq 425
Cdd:COG2319  217 KLLASGSADGTVRLWDLA-TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG----- 290

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912187 426 IYSMIYDANHGMLITGSS-----VMDMypltrmiqDTKQVPHT---HEREINVMLYNKYFHQVLTICSESIIRVWELETG 497
Cdd:COG2319  291 VNSVAFSPDGKLLASGSDdgtvrLWDL--------ATGKLLRTltgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG 362

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 767912187 498 LQVyQILEPHGfnTEVTSAAVDESGFLFATGAYNGTVRIWD 538
Cdd:COG2319  363 ELL-RTLTGHT--GAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
347-554 7.84e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 80.73  E-value: 7.84e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912187 347 VIVTGGDDKVIRLWHPNiSTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGGpgdmqI 426
Cdd:COG2319   92 LLASASADGTVRLWDLA-TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGA-----V 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912187 427 YSMIYDANHGMLITGSSvmdmyplTRMIQ----DTKQVPHT---HEREINVMLYNKYFHQVLTICSESIIRVWELETGLQ 499
Cdd:COG2319  166 TSVAFSPDGKLLASGSD-------DGTVRlwdlATGKLLRTltgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL 238

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767912187 500 VyQILEPHGFntEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDW 554
Cdd:COG2319  239 L-RTLTGHSG--SVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG 290
WD40 COG2319
WD40 repeat [General function prediction only];
345-554 3.03e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.39  E-value: 3.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912187 345 ANVIVTGGDDKVIRLWhPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGGpgdm 424
Cdd:COG2319   48 GARLAAGAGDLTLLLL-DAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGA---- 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912187 425 qIYSMIYDANHGMLITGSSvmdmypltrmiqdtkqvPHThereinvmlynkyfhqvlticsesiIRVWELETGlQVYQIL 504
Cdd:COG2319  123 -VRSVAFSPDGKTLASGSA-----------------DGT-------------------------VRLWDLATG-KLLRTL 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 767912187 505 EPHgfNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDW 554
Cdd:COG2319  159 TGH--SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA 206
WD40 COG2319
WD40 repeat [General function prediction only];
388-554 9.99e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.38  E-value: 9.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912187 388 DQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGgpgdmQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQVPHTHERE 467
Cdd:COG2319    6 GAALAAASADLALALLAAALGALLLLLLGLAA-----AVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912187 468 INVMLYNKYFHQVLTICSESIIRVWELETGLQvyqILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKV 547
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLL---LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT 157


                 ....*..
gi 767912187 548 LPEGKDW 554
Cdd:COG2319  158 LTGHSGA 164
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 368-554 1.09e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 57.34  E-value: 1.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912187 368 PVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGGpgdmqIYSMIYDANHGMLITGSsvMDm 447
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGP-----VRDVAASADGTYLASGS--SD- 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912187 448 ypltRMIQ----DTKQVPHT---HEREINVMLYNKYfHQVLTICSE-SIIRVWELETGLQVYQIlepHGFNTEVTSAAVD 519
Cdd:cd00200   73 ----KTIRlwdlETGECVRTltgHTSYVSSVAFSPD-GRILSSSSRdKTIKVWDVETGKCLTTL---RGHTDWVNSVAFS 144

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 767912187 520 ESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDW 554
Cdd:cd00200  145 PDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGE 179
WD40 COG2319
WD40 repeat [General function prediction only];
348-407 8.21e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.06  E-value: 8.21e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912187 348 IVTGGDDKVIRLWHPNiSTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQT 407
Cdd:COG2319  345 LASGSDDGTVRLWDLA-TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 507-538 1.05e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.05e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767912187   507 HGFNTEVTSAAVDESGFLFATGAYNGTVRIWD 538
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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