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Conserved domains on  [gi|767912631|ref|XP_011542568|]
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left-right determination factor 2 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TGFb_propeptide super family cl46657
TGF-beta propeptide; This propeptide is known as latency associated peptide (LAP) in TGF-beta. ...
 106-203 1.72e-07

TGF-beta propeptide; This propeptide is known as latency associated peptide (LAP) in TGF-beta. LAP is a homodimer which is disulfide linked to TGF-beta binding protein.


The actual alignment was detected with superfamily member pfam00688:

Pssm-ID: 480997  Cd Length: 239  Bit Score: 50.78  E-value: 1.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912631  106 RLPPNSELVQAVLRLFQEPVPKAALHRhgrlsprsaQARVTV-EWLRVRDDGSNRTSLIDSRLVSVHESGWKAFDVTEAV 184
Cdd:pfam00688 119 EIPEGELVTSAELRLYKDKVKARTSNE---------TFRIEVyQVLKEHDGGDASLRLLDSRLVTASEEGWLSFDVTEAL 189

                          90
                  ....*....|....*....
gi 767912631  185 NFWqqLSRPRQPLLLQVSV 203
Cdd:pfam00688 190 NRW--LANPEENLGLQLSV 206
 
Name Accession Description Interval E-value
TGFb_propeptide pfam00688
TGF-beta propeptide; This propeptide is known as latency associated peptide (LAP) in TGF-beta. ...
 106-203 1.72e-07

TGF-beta propeptide; This propeptide is known as latency associated peptide (LAP) in TGF-beta. LAP is a homodimer which is disulfide linked to TGF-beta binding protein.


Pssm-ID: 459906  Cd Length: 239  Bit Score: 50.78  E-value: 1.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912631  106 RLPPNSELVQAVLRLFQEPVPKAALHRhgrlsprsaQARVTV-EWLRVRDDGSNRTSLIDSRLVSVHESGWKAFDVTEAV 184
Cdd:pfam00688 119 EIPEGELVTSAELRLYKDKVKARTSNE---------TFRIEVyQVLKEHDGGDASLRLLDSRLVTASEEGWLSFDVTEAL 189

                          90
                  ....*....|....*....
gi 767912631  185 NFWqqLSRPRQPLLLQVSV 203
Cdd:pfam00688 190 NRW--LANPEENLGLQLSV 206
 
Name Accession Description Interval E-value
TGFb_propeptide pfam00688
TGF-beta propeptide; This propeptide is known as latency associated peptide (LAP) in TGF-beta. ...
 106-203 1.72e-07

TGF-beta propeptide; This propeptide is known as latency associated peptide (LAP) in TGF-beta. LAP is a homodimer which is disulfide linked to TGF-beta binding protein.


Pssm-ID: 459906  Cd Length: 239  Bit Score: 50.78  E-value: 1.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912631  106 RLPPNSELVQAVLRLFQEPVPKAALHRhgrlsprsaQARVTV-EWLRVRDDGSNRTSLIDSRLVSVHESGWKAFDVTEAV 184
Cdd:pfam00688 119 EIPEGELVTSAELRLYKDKVKARTSNE---------TFRIEVyQVLKEHDGGDASLRLLDSRLVTASEEGWLSFDVTEAL 189

                          90
                  ....*....|....*....
gi 767912631  185 NFWqqLSRPRQPLLLQVSV 203
Cdd:pfam00688 190 NRW--LANPEENLGLQLSV 206
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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