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integrator complex subunit 9 isoform X4 [Homo sapiens]
integrator complex subunit 9( domain architecture ID 11039990)
integrator complex subunit 9 is a component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing
List of domain hits
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Name | Accession | Description | Interval | E-value | ||||
metallo-hydrolase-like_MBL-fold super family | cl23716 | mainly hydrolytic enzymes and related proteins which carry out various biological functions; ... |
1-220 | 6.54e-56 | ||||
mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain; Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases which can catalyze the hydrolysis of a wide range of beta-lactam antibiotics, hydroxyacylglutathione hydrolases (also called glyoxalase II) which hydrolyze S-d-lactoylglutathione to d-lactate in the second step of the glycoxlase system, AHL lactonases which catalyze the hydrolysis and opening of the homoserine lactone rings of acyl homoserine lactones (AHLs), persulfide dioxygenase which catalyze the oxidation of glutathione persulfide to glutathione and persulfite in the mitochondria, flavodiiron proteins which catalyze the reduction of oxygen and/or nitric oxide to water or nitrous oxide respectively, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J which has both 5'-3' exoribonucleolytic and endonucleolytic activity and ribonuclease Z which catalyzes the endonucleolytic removal of the 3' extension of the majority of tRNA precursors, cyclic nucleotide phosphodiesterases which decompose cyclic adenosine and guanosine 3', 5'-monophosphate (cAMP and cGMP) respectively, insecticide hydrolases, and proteins required for natural transformation competence. The diversity of biological roles is reflected in variations in the active site metallo-chemistry, for example classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, human persulfide dioxygenase ETHE1 is a mono-iron binding member of the superfamily; Arabidopsis thaliana hydroxyacylglutathione hydrolases incorporates iron, manganese, and zinc in its dinuclear metal binding site, and flavodiiron proteins contains a diiron site. The actual alignment was detected with superfamily member cd16294: Pssm-ID: 451500 [Multi-domain] Cd Length: 166 Bit Score: 186.93 E-value: 6.54e-56
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Beta-Casp | smart01027 | Beta-Casp domain; The beta-CASP domain is found C terminal to the beta-lactamase domain in ... |
262-380 | 3.89e-24 | ||||
Beta-Casp domain; The beta-CASP domain is found C terminal to the beta-lactamase domain in pre-mRNA 3'-end-processing endonuclease. The active site of this enzyme is located at the interface of these two domains. : Pssm-ID: 214983 [Multi-domain] Cd Length: 126 Bit Score: 98.00 E-value: 3.89e-24
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Name | Accession | Description | Interval | E-value | |||||||
Int9-like_MBL-fold | cd16294 | integrator subunit 9, and related proteins; MBL-fold metallo-hydrolase domain; Integrator is a ... |
1-220 | 6.54e-56 | |||||||
integrator subunit 9, and related proteins; MBL-fold metallo-hydrolase domain; Integrator is a metazoan-specific multisubunit, multifunctional protein complex composed of 14 subunits named Int1-Int14 (Integrator subunits). This subgroup includes Int9, also known as protein related to CPSF subunits of 74 kDa (RC-74). Integrator complex has been implicated in a variety of Pol II transcription events including 3' end processing of snRNA, transcription initiation, promoter-proximal pausing, termination of protein-coding transcripts, and in HVS pre-miRNA 3' end processing. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. Pssm-ID: 293852 [Multi-domain] Cd Length: 166 Bit Score: 186.93 E-value: 6.54e-56
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Beta-Casp | smart01027 | Beta-Casp domain; The beta-CASP domain is found C terminal to the beta-lactamase domain in ... |
262-380 | 3.89e-24 | |||||||
Beta-Casp domain; The beta-CASP domain is found C terminal to the beta-lactamase domain in pre-mRNA 3'-end-processing endonuclease. The active site of this enzyme is located at the interface of these two domains. Pssm-ID: 214983 [Multi-domain] Cd Length: 126 Bit Score: 98.00 E-value: 3.89e-24
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YSH1 | COG1236 | RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure ... |
1-378 | 1.56e-08 | |||||||
RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]; Pssm-ID: 440849 [Multi-domain] Cd Length: 404 Bit Score: 57.12 E-value: 1.56e-08
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Beta-Casp | pfam10996 | Beta-Casp domain; The beta-CASP domain is found C terminal to the beta-lactamase domain in ... |
262-379 | 7.95e-06 | |||||||
Beta-Casp domain; The beta-CASP domain is found C terminal to the beta-lactamase domain in pre-mRNA 3'-end-processing endonuclease. The active site of this enzyme is located at the interface of these two domains. Pssm-ID: 463203 Cd Length: 109 Bit Score: 45.20 E-value: 7.95e-06
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Lactamase_B_6 | pfam16661 | Metallo-beta-lactamase superfamily domain; This family is part of the metallo-beta-lactamase ... |
53-205 | 7.17e-03 | |||||||
Metallo-beta-lactamase superfamily domain; This family is part of the metallo-beta-lactamase superfamily. Pssm-ID: 406948 Cd Length: 192 Bit Score: 37.96 E-value: 7.17e-03
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Name | Accession | Description | Interval | E-value | |||||||
Int9-like_MBL-fold | cd16294 | integrator subunit 9, and related proteins; MBL-fold metallo-hydrolase domain; Integrator is a ... |
1-220 | 6.54e-56 | |||||||
integrator subunit 9, and related proteins; MBL-fold metallo-hydrolase domain; Integrator is a metazoan-specific multisubunit, multifunctional protein complex composed of 14 subunits named Int1-Int14 (Integrator subunits). This subgroup includes Int9, also known as protein related to CPSF subunits of 74 kDa (RC-74). Integrator complex has been implicated in a variety of Pol II transcription events including 3' end processing of snRNA, transcription initiation, promoter-proximal pausing, termination of protein-coding transcripts, and in HVS pre-miRNA 3' end processing. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. Pssm-ID: 293852 [Multi-domain] Cd Length: 166 Bit Score: 186.93 E-value: 6.54e-56
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Int9-11_CPSF2-3-like_MBL-fold | cd07734 | Int9, Int11, CPSF2, CPSF3 and related cleavage and polyadenylation specificity factors; ... |
2-203 | 4.89e-37 | |||||||
Int9, Int11, CPSF2, CPSF3 and related cleavage and polyadenylation specificity factors; MBL-fold metallo-hydrolase domain; CPSF3 (cleavage and polyadenylation specificity factor subunit 3; also known as cleavage and polyadenylation specificity factor 73 kDa subunit, CPSF-73) and CPSF2 (also known as cleavage and polyadenylation specificity factor 100 kDa subunit /CPSF-100) are components of the CPSF complex, which plays a role in 3' end processing of pre-mRNAs during cleavage/polyadenylation, and during processing of metazoan histone pre-mRNAs. CPSF3 functions as a 3' endonuclease. Int11 (also known as cleavage and polyadenylation-specific factor (CPSF) 3-like protein, and protein related to CPSF subunits of 68 kDa (RC-68)), and Int9, also known as protein related to CPSF subunits of 74 kDa (RC-74) are subunits of Integrator, a metazoan-specific multifunctional protein complex composed of 14 subunits. Integrator has been implicated in a variety of Pol II transcription events including 3' end processing of snRNA, transcription initiation, promoter-proximal pausing, termination of protein-coding transcripts, and in HVS pre-miRNA 3' end processing. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. Pssm-ID: 293820 [Multi-domain] Cd Length: 193 Bit Score: 136.69 E-value: 4.89e-37
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Beta-Casp | smart01027 | Beta-Casp domain; The beta-CASP domain is found C terminal to the beta-lactamase domain in ... |
262-380 | 3.89e-24 | |||||||
Beta-Casp domain; The beta-CASP domain is found C terminal to the beta-lactamase domain in pre-mRNA 3'-end-processing endonuclease. The active site of this enzyme is located at the interface of these two domains. Pssm-ID: 214983 [Multi-domain] Cd Length: 126 Bit Score: 98.00 E-value: 3.89e-24
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CPSF3-like_MBL-fold | cd16292 | cleavage and polyadenylation specificity factor (CPSF) subunit 3 and related proteins; ... |
14-166 | 6.30e-16 | |||||||
cleavage and polyadenylation specificity factor (CPSF) subunit 3 and related proteins; MBL-fold metallo-hydrolase domain; CPSF3 (also known as cleavage and polyadenylation specificity factor 73 kDa subunit/CPSF-73) functions as a 3' endonuclease in 3' end processing of pre-mRNAs during cleavage/polyadenylation, and in 3' end processing of metazoan histone pre-mRNAs. This subgroup also contains the yeast homolog of CPSF-73, Ysh1/Brr5 which has roles in mRNA and snoRNA synthesis. In addition to this MBL-fold metallo-hydrolase domain, members of this subgroup contain a beta-CASP (named for metallo-beta-lactamase, CPSF, Artemis, Snm1, Pso2) domain, and a RMMBL domain (RNA-metabolizing metallo-beta-lactamase). Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. Pssm-ID: 293850 Cd Length: 194 Bit Score: 76.47 E-value: 6.30e-16
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YSH1 | COG1236 | RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure ... |
1-378 | 1.56e-08 | |||||||
RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]; Pssm-ID: 440849 [Multi-domain] Cd Length: 404 Bit Score: 57.12 E-value: 1.56e-08
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CPSF2-like_MBL-fold | cd16293 | cleavage and polyadenylation specificity factor (CPSF) subunit 2 and related proteins; ... |
7-204 | 4.03e-08 | |||||||
cleavage and polyadenylation specificity factor (CPSF) subunit 2 and related proteins; MBL-fold metallo-hydrolase domain; CPSF2, also known as cleavage and polyadenylation specificity factor 100 kDa subunit (CPSF-100), is a component of the CPSF complex, which plays a role in 3' end processing of pre-mRNAs during cleavage/polyadenylation, and during processing of metazoan histone pre-mRNAs. This subgroup includes Ydh1p, the yeast homolog of CPSF2. In addition to this MBL-fold metallo-hydrolase domain, members of this subgroup contain a beta-CASP (named for metallo-beta-lactamase, CPSF, Artemis, Snm1, Pso2) domain. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. Pssm-ID: 293851 Cd Length: 199 Bit Score: 53.68 E-value: 4.03e-08
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TTHA0252-CPSF-like_MBL-fold | cd16295 | Thermus thermophilus TTHA0252 and related cleavage and polyadenylation specificity factors; ... |
14-203 | 7.59e-06 | |||||||
Thermus thermophilus TTHA0252 and related cleavage and polyadenylation specificity factors; MBL-fold metallo-hydrolase domain; Includes the archaeal cleavage and polyadenylation specificity factors (CPSFs) such as Methanothermobacter thermautotrophicus MTH1203, and Pyrococcus horikoshii PH1404. In addition to the MBL-fold metallo-hydrolase nuclease and the beta-CASP domains, members of this subgroup contain two contiguous KH domains. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. Pssm-ID: 293853 [Multi-domain] Cd Length: 197 Bit Score: 47.07 E-value: 7.59e-06
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Beta-Casp | pfam10996 | Beta-Casp domain; The beta-CASP domain is found C terminal to the beta-lactamase domain in ... |
262-379 | 7.95e-06 | |||||||
Beta-Casp domain; The beta-CASP domain is found C terminal to the beta-lactamase domain in pre-mRNA 3'-end-processing endonuclease. The active site of this enzyme is located at the interface of these two domains. Pssm-ID: 463203 Cd Length: 109 Bit Score: 45.20 E-value: 7.95e-06
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INTS11-like_MBL-fold | cd16291 | Integrator complex subunit 11, and related proteins; MBL-fold metallo-hydrolase domain; ... |
96-207 | 9.39e-06 | |||||||
Integrator complex subunit 11, and related proteins; MBL-fold metallo-hydrolase domain; Integrator is a metazoan-specific multisubunit, multifunctional protein complex composed of 14 subunits named Int1-Int14 (Integrator subunits). This subgroup includes Int11 (also known as cleavage and polyadenylation-specific factor (CPSF) 3-like protein, and protein related to CPSF subunits of 68 kDa (RC-68)). Integrator complex has been implicated in a variety of Pol II transcription events including 3' end processing of snRNA, transcription initiation, promoter-proximal pausing, termination of protein-coding transcripts, and in HVS pre-miRNA 3' end processing. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. Pssm-ID: 293849 Cd Length: 199 Bit Score: 46.87 E-value: 9.39e-06
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Lactamase_B_6 | pfam16661 | Metallo-beta-lactamase superfamily domain; This family is part of the metallo-beta-lactamase ... |
53-205 | 7.17e-03 | |||||||
Metallo-beta-lactamase superfamily domain; This family is part of the metallo-beta-lactamase superfamily. Pssm-ID: 406948 Cd Length: 192 Bit Score: 37.96 E-value: 7.17e-03
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Blast search parameters | ||||
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