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Conserved domains on  [gi|767967497|ref|XP_011543061|]
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X-ray radiation resistance-associated protein 1 isoform X5 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
111-218 3.13e-11

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.11  E-value: 3.13e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967497 111 LDLSFNSLTvEAICDLGILPHLRVLLLTGNGLTSLPPNLAvaeqeasvtsltskryilRFPALETLMLDDNRLSNpscFA 190
Cdd:COG4886  187 LDLSNNQIT-DLPEPLGNLTNLEELDLSGNQLTDLPEPLA------------------NLTNLETLDLSNNQLTD---LP 244

                         90       100
                 ....*....|....*....|....*...
gi 767967497 191 SLAGLRRLKKLSLDENRIIRIPYLQQVQ 218
Cdd:COG4886  245 ELGNLTNLEELDLSNNQLTDLPPLANLT 272
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
111-218 3.13e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.11  E-value: 3.13e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967497 111 LDLSFNSLTvEAICDLGILPHLRVLLLTGNGLTSLPPNLAvaeqeasvtsltskryilRFPALETLMLDDNRLSNpscFA 190
Cdd:COG4886  187 LDLSNNQIT-DLPEPLGNLTNLEELDLSGNQLTDLPEPLA------------------NLTNLETLDLSNNQLTD---LP 244

                         90       100
                 ....*....|....*....|....*...
gi 767967497 191 SLAGLRRLKKLSLDENRIIRIPYLQQVQ 218
Cdd:COG4886  245 ELGNLTNLEELDLSNNQLTDLPPLANLT 272
LRR_8 pfam13855
Leucine rich repeat;
130-208 7.75e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 7.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967497  130 PHLRVLLLTGNGLTSLPPnlavaeqeasvtsltskRYILRFPALETLMLDDNRLS--NPSCFaslAGLRRLKKLSLDENR 207
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDD-----------------GAFKGLSNLKVLDLSNNLLTtlSPGAF---SGLPSLRYLDLSGNR 60


                  .
gi 767967497  208 I 208
Cdd:pfam13855  61 L 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 113-211 7.81e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.78  E-value: 7.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967497 113 LSFNSLTVEAICDLGILPHLRVLLLTGNGLTSLPpNLAvaeqeasvtsltskryilRFPALETLMLDDNRLSnpsCFASL 192
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIE-NLE------------------FLTNLTHLYLQNNQIE---KIENL 64

                         90
                 ....*....|....*....
gi 767967497 193 AGLRRLKKLSLDENRIIRI 211
Cdd:cd21340   65 ENLVNLKKLYLGGNRISVV 83
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
111-218 3.13e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.11  E-value: 3.13e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967497 111 LDLSFNSLTvEAICDLGILPHLRVLLLTGNGLTSLPPNLAvaeqeasvtsltskryilRFPALETLMLDDNRLSNpscFA 190
Cdd:COG4886  187 LDLSNNQIT-DLPEPLGNLTNLEELDLSGNQLTDLPEPLA------------------NLTNLETLDLSNNQLTD---LP 244

                         90       100
                 ....*....|....*....|....*...
gi 767967497 191 SLAGLRRLKKLSLDENRIIRIPYLQQVQ 218
Cdd:COG4886  245 ELGNLTNLEELDLSNNQLTDLPPLANLT 272
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
111-216 5.81e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.34  E-value: 5.81e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967497 111 LDLSFNSLTV--EAICDLgilPHLRVLLLTGNGLTSLPPNLAvaeqeasvtsltskryilRFPALETLMLDDNRLSNPSc 188
Cdd:COG4886  164 LDLSNNQLTDlpEELGNL---TNLKELDLSNNQITDLPEPLG------------------NLTNLEELDLSGNQLTDLP- 221

                         90       100
                 ....*....|....*....|....*...
gi 767967497 189 fASLAGLRRLKKLSLDENRIIRIPYLQQ 216
Cdd:COG4886  222 -EPLANLTNLETLDLSNNQLTDLPELGN 248
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
103-212 1.04e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.57  E-value: 1.04e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967497 103 SDLCTINFLDLSFNSLTvEAICDLGILPHLRVLLLTGNGLTSLPPNLAVAEQ----EASVTSLTS-KRYILRFPALETLM 177
Cdd:COG4886  110 SNLTNLESLDLSGNQLT-DLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNlkslDLSNNQLTDlPEELGNLTNLKELD 188

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 767967497 178 LDDNRLSNPScfASLAGLRRLKKLSLDENRIIRIP 212
Cdd:COG4886  189 LSNNQITDLP--EPLGNLTNLEELDLSGNQLTDLP 221
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
103-212 1.06e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.94  E-value: 1.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967497 103 SDLCTINFLDLSFNSltveaicDLGILPHLRVLLLTGNGLTSLPPNLAVAEQ-------EASVTSLTSKryILRFPALET 175
Cdd:COG4886   93 GDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELANLTNlkeldlsNNQLTDLPEP--LGNLTNLKS 163

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767967497 176 LMLDDNRLSN-PScfaSLAGLRRLKKLSLDENRIIRIP 212
Cdd:COG4886  164 LDLSNNQLTDlPE---ELGNLTNLKELDLSNNQITDLP 198
LRR_8 pfam13855
Leucine rich repeat;
130-208 7.75e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 7.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967497  130 PHLRVLLLTGNGLTSLPPnlavaeqeasvtsltskRYILRFPALETLMLDDNRLS--NPSCFaslAGLRRLKKLSLDENR 207
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDD-----------------GAFKGLSNLKVLDLSNNLLTtlSPGAF---SGLPSLRYLDLSGNR 60


                  .
gi 767967497  208 I 208
Cdd:pfam13855  61 L 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 113-211 7.81e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.78  E-value: 7.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967497 113 LSFNSLTVEAICDLGILPHLRVLLLTGNGLTSLPpNLAvaeqeasvtsltskryilRFPALETLMLDDNRLSnpsCFASL 192
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIE-NLE------------------FLTNLTHLYLQNNQIE---KIENL 64

                         90
                 ....*....|....*....
gi 767967497 193 AGLRRLKKLSLDENRIIRI 211
Cdd:cd21340   65 ENLVNLKKLYLGGNRISVV 83
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
107-212 1.56e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.92  E-value: 1.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967497 107 TINFLDLSFNSLTVEAICDLGILPHLRVLLLTGNGLTSLPPNLAVAEQEASVTSLTSKRYILRFPALETLMLDDNRLSN- 185
Cdd:COG4886   49 LTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDl 128

                         90       100
                 ....*....|....*....|....*..
gi 767967497 186 PscfASLAGLRRLKKLSLDENRIIRIP 212
Cdd:COG4886  129 P---EELANLTNLKELDLSNNQLTDLP 152
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 117-212 1.97e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 1.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967497 117 SLTVEAICDLGILPHLRVLLLTGNGLTSLPPnLAVaeqeasvtsltskryilrFPALETLMLDDNRLSNPSCFA-SLAGL 195
Cdd:cd21340  107 KLTFDPRSLAALSNSLRVLNISGNNIDSLEP-LAP------------------LRNLEQLDASNNQISDLEELLdLLSSW 167

                         90
                 ....*....|....*..
gi 767967497 196 RRLKKLSLDENRIIRIP 212
Cdd:cd21340  168 PSLRELDLTGNPVCKKP 184
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
103-185 2.54e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.07  E-value: 2.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967497 103 SDLCTINFLDLSFNSLTvEAICDLGILPHLRVLLLTGNGLTSLP-----PNLAVAEqeASVTSLTSKRYILRFPALETLM 177
Cdd:COG4886  202 GNLTNLEELDLSGNQLT-DLPEPLANLTNLETLDLSNNQLTDLPelgnlTNLEELD--LSNNQLTDLPPLANLTNLKTLD 278


                 ....*...
gi 767967497 178 LDDNRLSN 185
Cdd:COG4886  279 LSNNQLTD 286
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 105-208 8.94e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 38.88  E-value: 8.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967497 105 LCTINFLDLSFNSLTVEAI---C-DLGILPHLRVLLLTGNGLTslppnlavaEQEASVTSLTskryILRFPALETLMLDD 180
Cdd:cd00116  164 NRDLKELNLANNGIGDAGIralAeGLKANCNLEVLDLNNNGLT---------DEGASALAET----LASLKSLEVLNLGD 230

                         90       100       110
                 ....*....|....*....|....*....|..
gi 767967497 181 NRLSNPS----CFASLAGLRRLKKLSLDENRI 208
Cdd:cd00116  231 NNLTDAGaaalASALLSPNISLLTLSLSCNDI 262
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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