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Conserved domains on  [gi|767968133|ref|XP_011543315|]
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dnaJ homolog subfamily B member 13 isoform X5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DnaJ_bact super family cl37091
chaperone protein DnaJ; This model represents bacterial forms of DnaJ, part of the ...
 48-197 1.54e-28

chaperone protein DnaJ; This model represents bacterial forms of DnaJ, part of the DnaK-DnaJ-GrpE chaperone system. The three components typically are encoded by consecutive genes. DnaJ homologs occur in many genomes, typically not near DnaK and GrpE-like genes; most such genes are not included by this family. Eukaryotic (mitochondrial and chloroplast) forms are not included in the scope of this family.


The actual alignment was detected with superfamily member TIGR02349:

Pssm-ID: 274090 [Multi-domain]  Cd Length: 354  Bit Score: 110.77  E-value: 1.54e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133   48 HSTAEDKDQRYRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGIPLEFGSQTPWTTGyvfh 127
Cdd:TIGR02349  11 DASEEEIKKAYRKLAKKYHPDRNKDKEAEEKFKEINEAYEVLSDPEKRAQYDQFGHAGFNGGGGGGGGGFNGFDIG---- 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767968133  128 gkpekvfheFFGG-NNPFSEFFDAEGSevdlnfGGLQGRGVKKQDPQVERDLYLSLEDLFFGCTKKIKISR 197
Cdd:TIGR02349  87 ---------FFGDfGDIFGDFFGGGGG------SGRRRRSGPRRGEDLRYDLELTFEEAVFGVEKEIEIPR 142
DnaJ_C super family cl47019
C-terminal substrate binding domain of DnaJ and HSP40; The C-terminal region of the DnaJ/Hsp40 ...
 174-238 1.66e-15

C-terminal substrate binding domain of DnaJ and HSP40; The C-terminal region of the DnaJ/Hsp40 protein mediates oligomerization and binding to denatured polypeptide substrate. DnaJ/Hsp40 is a widely conserved heat-shock protein. It prevents the aggregation of unfolded substrate and forms a ternary complex with both substrate and DnaK/Hsp70; the N-terminal J-domain of DnaJ/Hsp40 stimulates the ATPase activity of DnaK/Hsp70.


The actual alignment was detected with superfamily member cd10747:

Pssm-ID: 199909 [Multi-domain]  Cd Length: 158  Bit Score: 71.30  E-value: 1.66e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767968133 174 VERDLYLSLEDLFFGCTKKIKISRRVLnedgysSTIKDKILTIDVKPGWRQGTRITFEKEGDQRP 238
Cdd:cd10747    3 LRYDLELTLEEAYFGKEKEIKIPRKVT------RVREKKTLTVKIPAGVDDGQRLRLRGEGDAGP 61
 
Name Accession Description Interval E-value
DnaJ_bact TIGR02349
chaperone protein DnaJ; This model represents bacterial forms of DnaJ, part of the ...
 48-197 1.54e-28

chaperone protein DnaJ; This model represents bacterial forms of DnaJ, part of the DnaK-DnaJ-GrpE chaperone system. The three components typically are encoded by consecutive genes. DnaJ homologs occur in many genomes, typically not near DnaK and GrpE-like genes; most such genes are not included by this family. Eukaryotic (mitochondrial and chloroplast) forms are not included in the scope of this family.


Pssm-ID: 274090 [Multi-domain]  Cd Length: 354  Bit Score: 110.77  E-value: 1.54e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133   48 HSTAEDKDQRYRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGIPLEFGSQTPWTTGyvfh 127
Cdd:TIGR02349  11 DASEEEIKKAYRKLAKKYHPDRNKDKEAEEKFKEINEAYEVLSDPEKRAQYDQFGHAGFNGGGGGGGGGFNGFDIG---- 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767968133  128 gkpekvfheFFGG-NNPFSEFFDAEGSevdlnfGGLQGRGVKKQDPQVERDLYLSLEDLFFGCTKKIKISR 197
Cdd:TIGR02349  87 ---------FFGDfGDIFGDFFGGGGG------SGRRRRSGPRRGEDLRYDLELTFEEAVFGVEKEIEIPR 142
PRK14298 PRK14298
chaperone protein DnaJ; Provisional
 49-197 9.43e-22

chaperone protein DnaJ; Provisional


Pssm-ID: 184612 [Multi-domain]  Cd Length: 377  Bit Score: 92.60  E-value: 9.43e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133  49 STAEDKDQRYRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGgiplefgsqtPWTTGYVFHG 128
Cdd:PRK14298  17 ASVEDIKKAYRKLAMKYHPDKNKEPDAEEKFKEISEAYAVLSDAEKRAQYDRFGHAGIDN----------QYSAEDIFRG 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767968133 129 KPekvfhefFGGnnpFSEFFdaegsevDLNFGGlqGRGVKKQDPQ----VERDLYLSLEDLFFGCTKKIKISR 197
Cdd:PRK14298  87 AD-------FGG---FGDIF-------EMFFGG--GGRRGRMGPRrgsdLRYDLYITLEEAAFGVRKDIDVPR 140
terminal_TopJ NF037946
terminal organelle assembly protein TopJ;
58-155 2.32e-20

terminal organelle assembly protein TopJ;


Pssm-ID: 468284 [Multi-domain]  Cd Length: 440  Bit Score: 89.11  E-value: 2.32e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133  58 YRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGIPLEFgsqtpwttgyvfhgKPEKVFHEF 137
Cdd:NF037946  26 FRKLAKKYHPDRNKAPDAAEIFAEINEAYEVLSNPEKRANYDKYGHDGVDGEGGFGF--------------DAFDVFSSF 91

                         90
                 ....*....|....*...
gi 767968133 138 FGGNNPFSEFFDAEGSEV 155
Cdd:NF037946  92 FETINKSGAFLDDSVDES 109
DnaJ COG0484
DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational ...
 50-106 6.30e-16

DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440252 [Multi-domain]  Cd Length: 139  Bit Score: 72.04  E-value: 6.30e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767968133  50 TAEDKDQRYRRLALKHHPLKS-NEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGL 106
Cdd:COG0484   13 SAEEIKKAYRKLAKKYHPDRNpGDPEAEEKFKEINEAYEVLSDPEKRAAYDRFGHAAE 70
DnaJ_C cd10747
C-terminal substrate binding domain of DnaJ and HSP40; The C-terminal region of the DnaJ/Hsp40 ...
 174-238 1.66e-15

C-terminal substrate binding domain of DnaJ and HSP40; The C-terminal region of the DnaJ/Hsp40 protein mediates oligomerization and binding to denatured polypeptide substrate. DnaJ/Hsp40 is a widely conserved heat-shock protein. It prevents the aggregation of unfolded substrate and forms a ternary complex with both substrate and DnaK/Hsp70; the N-terminal J-domain of DnaJ/Hsp40 stimulates the ATPase activity of DnaK/Hsp70.


Pssm-ID: 199909 [Multi-domain]  Cd Length: 158  Bit Score: 71.30  E-value: 1.66e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767968133 174 VERDLYLSLEDLFFGCTKKIKISRRVLnedgysSTIKDKILTIDVKPGWRQGTRITFEKEGDQRP 238
Cdd:cd10747    3 LRYDLELTLEEAYFGKEKEIKIPRKVT------RVREKKTLTVKIPAGVDDGQRLRLRGEGDAGP 61
DnaJ pfam00226
DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is ...
 48-99 3.43e-15

DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.


Pssm-ID: 395170 [Multi-domain]  Cd Length: 63  Bit Score: 67.88  E-value: 3.43e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767968133   48 HSTAEDKD--QRYRRLALKHHPLK-SNEPSSAEIFRQIAEAYDVLSDPMKRGIYD 99
Cdd:pfam00226   9 SPDASDEEikKAYRKLALKYHPDKnPGDPEAEEKFKEINEAYEVLSDPEKRAIYD 63
DnaJ smart00271
DnaJ molecular chaperone homology domain;
47-94 4.54e-12

DnaJ molecular chaperone homology domain;


Pssm-ID: 197617 [Multi-domain]  Cd Length: 60  Bit Score: 59.56  E-value: 4.54e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 767968133    47 EHSTAEDKDQRYRRLALKHHP--LKSNEPSSAEIFRQIAEAYDVLSDPMK 94
Cdd:smart00271  11 RDASLDEIKKAYRKLALKYHPdkNPGDKEEAEEKFKEINEAYEVLSDPEK 60
DnaJ cd06257
DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and ...
 47-91 3.82e-10

DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonine family. Hsp40 proteins are characterized by the presence of a J domain, which mediates the interaction with Hsp70. They may contain other domains as well, and the architectures provide a means of classification.


Pssm-ID: 99751 [Multi-domain]  Cd Length: 55  Bit Score: 54.09  E-value: 3.82e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 767968133  47 EHSTAEDKDQRYRRLALKHHPLK-SNEPSSAEIFRQIAEAYDVLSD 91
Cdd:cd06257   10 PDASDEEIKKAYRKLALKYHPDKnPDDPEAEEKFKEINEAYEVLSD 55
DnaJ_C pfam01556
DnaJ C terminal domain; This family consists of the C terminal region of the DnaJ protein. It ...
 174-235 5.08e-09

DnaJ C terminal domain; This family consists of the C terminal region of the DnaJ protein. It is always found associated with pfam00226 and pfam00684. DnaJ is a chaperone associated with the Hsp70 heat-shock system involved in protein folding and renaturation after stress. The two C-terminal domains CTDI and CTDII, both incorporated in this family are necessary for maintaining the J-domains in their specific relative positions. Structural analysis of PDB:1nlt shows that PF00684 is nested within this DnaJ C-terminal region.


Pssm-ID: 460251 [Multi-domain]  Cd Length: 213  Bit Score: 54.57  E-value: 5.08e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133  174 VERDLYLSLEDLFFGCTKKIKISRRVLNED-------------------------------------------------- 203
Cdd:pfam01556   1 LEYELELTLEEAYFGCTKKIKITRNVICDTcggsgakpgtspktcpccggggqvrrqfgffstctccpccggggkiidkc 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 767968133  204 ----GYSSTIKDKILTIDVKPGWRQGTRITFEKEGD 235
Cdd:pfam01556  81 ckccGGGGVVEKKTLEVKIPAGVDDGQRIRLRGEGD 116
 
Name Accession Description Interval E-value
DnaJ_bact TIGR02349
chaperone protein DnaJ; This model represents bacterial forms of DnaJ, part of the ...
 48-197 1.54e-28

chaperone protein DnaJ; This model represents bacterial forms of DnaJ, part of the DnaK-DnaJ-GrpE chaperone system. The three components typically are encoded by consecutive genes. DnaJ homologs occur in many genomes, typically not near DnaK and GrpE-like genes; most such genes are not included by this family. Eukaryotic (mitochondrial and chloroplast) forms are not included in the scope of this family.


Pssm-ID: 274090 [Multi-domain]  Cd Length: 354  Bit Score: 110.77  E-value: 1.54e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133   48 HSTAEDKDQRYRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGIPLEFGSQTPWTTGyvfh 127
Cdd:TIGR02349  11 DASEEEIKKAYRKLAKKYHPDRNKDKEAEEKFKEINEAYEVLSDPEKRAQYDQFGHAGFNGGGGGGGGGFNGFDIG---- 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767968133  128 gkpekvfheFFGG-NNPFSEFFDAEGSevdlnfGGLQGRGVKKQDPQVERDLYLSLEDLFFGCTKKIKISR 197
Cdd:TIGR02349  87 ---------FFGDfGDIFGDFFGGGGG------SGRRRRSGPRRGEDLRYDLELTFEEAVFGVEKEIEIPR 142
PRK14298 PRK14298
chaperone protein DnaJ; Provisional
 49-197 9.43e-22

chaperone protein DnaJ; Provisional


Pssm-ID: 184612 [Multi-domain]  Cd Length: 377  Bit Score: 92.60  E-value: 9.43e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133  49 STAEDKDQRYRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGgiplefgsqtPWTTGYVFHG 128
Cdd:PRK14298  17 ASVEDIKKAYRKLAMKYHPDKNKEPDAEEKFKEISEAYAVLSDAEKRAQYDRFGHAGIDN----------QYSAEDIFRG 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767968133 129 KPekvfhefFGGnnpFSEFFdaegsevDLNFGGlqGRGVKKQDPQ----VERDLYLSLEDLFFGCTKKIKISR 197
Cdd:PRK14298  87 AD-------FGG---FGDIF-------EMFFGG--GGRRGRMGPRrgsdLRYDLYITLEEAAFGVRKDIDVPR 140
PRK10767 PRK10767
chaperone protein DnaJ; Provisional
 50-199 1.88e-21

chaperone protein DnaJ; Provisional


Pssm-ID: 236757 [Multi-domain]  Cd Length: 371  Bit Score: 91.36  E-value: 1.88e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133  50 TAEDKD--QRYRRLALKHHPLK-SNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGIPlefgsqtpwTTGyvf 126
Cdd:PRK10767  15 NASEDEikKAYRKLAMKYHPDRnPGDKEAEEKFKEIKEAYEVLSDPQKRAAYDQYGHAAFEQGGG---------GGG--- 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133 127 hgkpekvfhefFGGNNPFSEFF-DAEGsevDLnFGGLQGRGvkkqDPQVER------DLYLSLEDLFFGCTKKIKISRRV 199
Cdd:PRK10767  83 -----------FGGGGGFGDIFgDIFG---DI-FGGGRGGG----RQRARRgadlryNMEITLEEAVRGVTKEIRIPTLV 143
PTZ00037 PTZ00037
DnaJ_C chaperone protein; Provisional
 42-228 5.02e-21

DnaJ_C chaperone protein; Provisional


Pssm-ID: 240236 [Multi-domain]  Cd Length: 421  Bit Score: 91.04  E-value: 5.02e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133  42 VNIHLEHSTAEDKdQRYRRLALKHHPLKSNEPssaEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGIPlefgsqtpwt 121
Cdd:PTZ00037  34 LNLSKDCTTSEIK-KAYRKLAIKHHPDKGGDP---EKFKEISRAYEVLSDPEKRKIYDEYGEEGLEGGEQ---------- 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133 122 tgyvfHGKPEKVFheffggnnpfseffdaegsevDLNFGGLQGRGVKKQDPQVERDLYLSLEDLFFGCTKKIKISRRVL- 200
Cdd:PTZ00037 100 -----PADASDLF---------------------DLIFGGGRKPGGKKRGEDIVSHLKVTLEQIYNGAMRKLAINKDVIc 153

                        170       180
                 ....*....|....*....|....*....
gi 767968133 201 -NEDGYSSTiKDKILTIDVKPGwrQGTRI 228
Cdd:PTZ00037 154 aNCEGHGGP-KDAFVDCKLCNG--QGIRV 179
terminal_TopJ NF037946
terminal organelle assembly protein TopJ;
58-155 2.32e-20

terminal organelle assembly protein TopJ;


Pssm-ID: 468284 [Multi-domain]  Cd Length: 440  Bit Score: 89.11  E-value: 2.32e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133  58 YRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGIPLEFgsqtpwttgyvfhgKPEKVFHEF 137
Cdd:NF037946  26 FRKLAKKYHPDRNKAPDAAEIFAEINEAYEVLSNPEKRANYDKYGHDGVDGEGGFGF--------------DAFDVFSSF 91

                         90
                 ....*....|....*...
gi 767968133 138 FGGNNPFSEFFDAEGSEV 155
Cdd:NF037946  92 FETINKSGAFLDDSVDES 109
PRK14299 PRK14299
chaperone protein DnaJ; Provisional
 47-236 3.94e-20

chaperone protein DnaJ; Provisional


Pssm-ID: 237667 [Multi-domain]  Cd Length: 291  Bit Score: 86.92  E-value: 3.94e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133  47 EHSTAEDKDQRYRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGIPlefGSQTPWTTGYVF 126
Cdd:PRK14299  14 KNASQDEIKKAFKKLARKYHPDVNKSPGAEEKFKEINEAYTVLSDPEKRRIYDTYGTTAASAGWQ---GPPPGPPGGGDF 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133 127 HGKPEKVFHEF----FGGNNPFSEFFDAEGSevdlnfgglQGRGVKK-QDpqVERDLYLSLEDLFFGCTKKIKISRRVln 201
Cdd:PRK14299  91 SGFNVGDFSDFfqqlFGGRGGFGGFGDLFGS---------VGRRARKgRD--LEAELPLTLEEAYRGGEKVVEVAGER-- 157

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 767968133 202 edgysstikdkiLTIDVKPGWRQGTRITFEKEGDQ 236
Cdd:PRK14299 158 ------------LSVRIPPGVREGQVIRLAGKGRQ 180
PRK14291 PRK14291
chaperone protein DnaJ; Provisional
 49-199 1.51e-19

chaperone protein DnaJ; Provisional


Pssm-ID: 237661 [Multi-domain]  Cd Length: 382  Bit Score: 86.36  E-value: 1.51e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133  49 STAEDKDQRYRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGIPlEFGSQTPWTTgyVFHG 128
Cdd:PRK14291  15 ATQEEIKKAYRRLARKYHPDFNKNPEAEEKFKEINEAYQVLSDPEKRKLYDQFGHAAFSGSGQ-QQQGQEGFSD--FGGG 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767968133 129 KPEKVFHEFFGGNNpFSEFFDAEGSEvdlnfgglQGRGVKKQDPQVERDLY----LSLEDLFFGCTKKIKISRRV 199
Cdd:PRK14291  92 NIEDILEDVFDIFG-FGDIFGRRRAT--------RERRKTYQRPVKGEDIYqtveISLEEAYTGTTVSLEVPRYV 157
PRK14290 PRK14290
chaperone protein DnaJ; Provisional
 48-214 4.94e-19

chaperone protein DnaJ; Provisional


Pssm-ID: 172778 [Multi-domain]  Cd Length: 365  Bit Score: 84.60  E-value: 4.94e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133  48 HSTAEDKDQRYRRLALKHHP--LKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGiplefGSQTPWTTgYV 125
Cdd:PRK14290  14 NASQEDIKKAFRELAKKWHPdlHPGNKAEAEEKFKEISEAYEVLSDPQKRRQYDQTGTVDFGAG-----GSNFNWDN-FT 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133 126 FHGKPEKVFHEFFGGNnpFSEFFdaegsevdlnFGGLqgrGVKKQDPQVERDLYL----SLEDLFFGCTKKIKISRRVLN 201
Cdd:PRK14290  88 HFSDINDIFNQIFGGN--FGSDF----------FSGF---GNQQSTRNIDLDIYTnldiSLEDAYYGTEKRIKYRRNAMC 152

                        170
                 ....*....|...
gi 767968133 202 EDGYSSTIKDKIL 214
Cdd:PRK14290 153 PDCSGTGAKNGKL 165
PRK14276 PRK14276
chaperone protein DnaJ; Provisional
 58-197 5.32e-19

chaperone protein DnaJ; Provisional


Pssm-ID: 237653 [Multi-domain]  Cd Length: 380  Bit Score: 84.75  E-value: 5.32e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133  58 YRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGipleFGSQtpwttGYVFHGkpekvfhef 137
Cdd:PRK14276  25 YRKLSKKYHPDINKEPGAEEKYKEVQEAYETLSDPQKRAAYDQYGAAGANGG----FGGG-----AGGFGG--------- 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767968133 138 FGGNNPFSEFFDAEGSevdlNFGGlQGRGVKKQDPQVERDL-Y---LSLEDLFFGCTKKIKISR 197
Cdd:PRK14276  87 FDGSGGFGGFEDIFSS----FFGG-GGARRNPNAPRQGDDLqYrvnLDFEEAIFGKEKEVSYNR 145
PRK14280 PRK14280
molecular chaperone DnaJ;
49-199 8.34e-19

molecular chaperone DnaJ;


Pssm-ID: 237656 [Multi-domain]  Cd Length: 376  Bit Score: 84.39  E-value: 8.34e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133  49 STAEDKDQRYRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGipleFGSQtpwttgyvfhG 128
Cdd:PRK14280  16 ASKDEIKKAYRKLSKKYHPDINKEEGADEKFKEISEAYEVLSDDQKRAQYDQFGHAGPNQG----FGGG----------G 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767968133 129 KPEKVFHEFFGGNNPFSEFFdaegsevdlnfgglqGRGVKKQDPQVER---DL-Y---LSLEDLFFGCTKKIKISRRV 199
Cdd:PRK14280  82 FGGGDFGGGFGFEDIFSSFF---------------GGGGRRRDPNAPRqgaDLqYtmtLTFEEAVFGKEKEIEIPKEE 144
PRK14283 PRK14283
chaperone protein DnaJ; Provisional
 50-200 3.70e-18

chaperone protein DnaJ; Provisional


Pssm-ID: 184604 [Multi-domain]  Cd Length: 378  Bit Score: 82.56  E-value: 3.70e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133  50 TAEDKD--QRYRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGgipleFgSQTPWTTGYVFh 127
Cdd:PRK14283  16 NADKKEikKAYRKLARKYHPDVSEEEGAEEKFKEISEAYAVLSDDEKRQRYDQFGHAGMDG-----F-SQEDIFNNINF- 88

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767968133 128 gkpEKVFHEFFGGnnpFSEFFDAEGsevdlnFGGLQGRGvkkqdPQVERDLY----LSLEDLFFGCTKKIKISRRVL 200
Cdd:PRK14283  89 ---EDIFQGFGFG---IGNIFDMFG------FGGGSRHG-----PQRGADIYteveITLEEAASGVEKDIKVRHTKK 148
PRK14293 PRK14293
molecular chaperone DnaJ;
49-196 1.23e-17

molecular chaperone DnaJ;


Pssm-ID: 237663 [Multi-domain]  Cd Length: 374  Bit Score: 80.80  E-value: 1.23e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133  49 STAEDKDQRYRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKG--GIPlEFGSQtpwttgyvf 126
Cdd:PRK14293  15 ADKDELKRAYRRLARKYHPDVNKEPGAEDRFKEINRAYEVLSDPETRARYDQFGEAGVSGaaGFP-DMGDM--------- 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767968133 127 hGKPEKVFHEFFGGnnpfseffdaegsevdlnFGGL--QGRGVKKQDPQ----VERDLYLSLEDLFFGCTKKIKIS 196
Cdd:PRK14293  85 -GGFADIFETFFSG------------------FGGAggQGGRRRRRGPQrgddLRYDLKLDFREAIFGGEKEIRIP 141
PRK14294 PRK14294
chaperone protein DnaJ; Provisional
 49-197 3.73e-17

chaperone protein DnaJ; Provisional


Pssm-ID: 237664 [Multi-domain]  Cd Length: 366  Bit Score: 79.42  E-value: 3.73e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133  49 STAEDKDQRYRRLALKHHPLKS-NEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGgiplefgsqtpwtTGYVFH 127
Cdd:PRK14294  16 ASEEEIKKSYRKLAMKYHPDRNpGDKEAEELFKEAAEAYEVLSDPKKRGIYDQYGHEGLSG-------------TGFSGF 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767968133 128 GKPEKVFHEFfggNNPFSEFFdaegsevdlNFGGL---QGRGVKKQDPQVERDLYLSLEDLFFGCTKKIKISR 197
Cdd:PRK14294  83 SGFDDIFSSF---GDIFEDFF---------GFGGGrrgRSRTAVRAGADLRYDLTLPFLEAAFGTEKEIRIQK 143
PRK14285 PRK14285
chaperone protein DnaJ; Provisional
 58-202 4.33e-16

chaperone protein DnaJ; Provisional


Pssm-ID: 172773 [Multi-domain]  Cd Length: 365  Bit Score: 76.57  E-value: 4.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133  58 YRRLALKHHPLKSNEPSSAE-IFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGiplefgsqtpwttgyvfhgkpeKVFHE 136
Cdd:PRK14285  24 YRKIAIKYHPDKNKGNKEAEsIFKEATEAYEVLIDDNKRAQYDRFGHTAFEGG----------------------GGFEG 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767968133 137 FFGGNNPFSEFFDAEGSEVDLNFGGLQGRGVKKQDPQVERDLY---LSLEDLFFGCTKKIKISRRVLNE 202
Cdd:PRK14285  82 FSGGFSGFSDIFEDFGDIFDSFFTGNRGQDKNRKHEKGQDLTYqieISLEDAYLGYKNNINITRNMLCE 150
DnaJ COG0484
DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational ...
 50-106 6.30e-16

DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440252 [Multi-domain]  Cd Length: 139  Bit Score: 72.04  E-value: 6.30e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767968133  50 TAEDKDQRYRRLALKHHPLKS-NEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGL 106
Cdd:COG0484   13 SAEEIKKAYRKLAKKYHPDRNpGDPEAEEKFKEINEAYEVLSDPEKRAAYDRFGHAAE 70
PRK14277 PRK14277
chaperone protein DnaJ; Provisional
 49-197 9.35e-16

chaperone protein DnaJ; Provisional


Pssm-ID: 184599 [Multi-domain]  Cd Length: 386  Bit Score: 75.61  E-value: 9.35e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133  49 STAEDKDQRYRRLALKHHP-LKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKggiPLEFGSqtpwtTGYVFH 127
Cdd:PRK14277  17 ATEEEIKKAYRRLAKKYHPdLNPGDKEAEQKFKEINEAYEILSDPQKRAQYDQFGHAAFD---PGGFGQ-----GGFGQG 88

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767968133 128 GKPEKVFHEFFGG-NNPFSEFFDAegsevdlNFGGlqGRGVKKQDPQ----VERDLYLSLEDLFFGCTKKIKISR 197
Cdd:PRK14277  89 GFGGGGFDFDFGGfGDIFEDIFGD-------FFGT--GRRRAETGPQkgadIRYDLELTFEEAAFGTEKEIEVER 154
DnaJ_C cd10747
C-terminal substrate binding domain of DnaJ and HSP40; The C-terminal region of the DnaJ/Hsp40 ...
 174-238 1.66e-15

C-terminal substrate binding domain of DnaJ and HSP40; The C-terminal region of the DnaJ/Hsp40 protein mediates oligomerization and binding to denatured polypeptide substrate. DnaJ/Hsp40 is a widely conserved heat-shock protein. It prevents the aggregation of unfolded substrate and forms a ternary complex with both substrate and DnaK/Hsp70; the N-terminal J-domain of DnaJ/Hsp40 stimulates the ATPase activity of DnaK/Hsp70.


Pssm-ID: 199909 [Multi-domain]  Cd Length: 158  Bit Score: 71.30  E-value: 1.66e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767968133 174 VERDLYLSLEDLFFGCTKKIKISRRVLnedgysSTIKDKILTIDVKPGWRQGTRITFEKEGDQRP 238
Cdd:cd10747    3 LRYDLELTLEEAYFGKEKEIKIPRKVT------RVREKKTLTVKIPAGVDDGQRLRLRGEGDAGP 61
PRK14286 PRK14286
chaperone protein DnaJ; Provisional
 58-197 2.13e-15

chaperone protein DnaJ; Provisional


Pssm-ID: 172774 [Multi-domain]  Cd Length: 372  Bit Score: 74.64  E-value: 2.13e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133  58 YRRLALKHHPLKSN-EPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGIPlEFGsQTPWTTgyvfhgkpekvFHE 136
Cdd:PRK14286  25 YRKLAIKYHPDKNKgNKESEEKFKEATEAYEILRDPKKRQAYDQFGKAGVNAGAG-GFG-QGAYTD-----------FSD 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767968133 137 FFGG-NNPFSEFFDAEGSEvdlNFGGlqGRgvkKQDPQVERDLY----LSLEDLFFGCTKKIKISR 197
Cdd:PRK14286  92 IFGDfGDIFGDFFGGGRGG---GSGG--GR---RSGPQRGSDLRynleVSLEDAALGREYKIEIPR 149
PRK14297 PRK14297
molecular chaperone DnaJ;
46-197 2.53e-15

molecular chaperone DnaJ;


Pssm-ID: 184611 [Multi-domain]  Cd Length: 380  Bit Score: 74.43  E-value: 2.53e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133  46 LEHSTAEDKDQR-YRRLALKHHPLKS-NEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGipLEFGSQTPWTTG 123
Cdd:PRK14297  12 LEKGASDDEIKKaFRKLAIKYHPDKNkGNKEAEEKFKEINEAYQVLSDPQKKAQYDQFGTADFNGA--GGFGSGGFGGFD 89

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767968133 124 YVFHGKPEKVFHEFFGgnnpfseffdaegsevdlnfGGLQGRGVKKQDPQ----VERDLYLSLEDLFFGCTKKIKISR 197
Cdd:PRK14297  90 FSDMGGFGDIFDSFFG--------------------GGFGSSSRRRNGPQrgadIEYTINLTFEEAVFGVEKEISVTR 147
DnaJ pfam00226
DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is ...
 48-99 3.43e-15

DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.


Pssm-ID: 395170 [Multi-domain]  Cd Length: 63  Bit Score: 67.88  E-value: 3.43e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767968133   48 HSTAEDKD--QRYRRLALKHHPLK-SNEPSSAEIFRQIAEAYDVLSDPMKRGIYD 99
Cdd:pfam00226   9 SPDASDEEikKAYRKLALKYHPDKnPGDPEAEEKFKEINEAYEVLSDPEKRAIYD 63
PRK14289 PRK14289
molecular chaperone DnaJ;
49-199 3.26e-14

molecular chaperone DnaJ;


Pssm-ID: 237660 [Multi-domain]  Cd Length: 386  Bit Score: 71.02  E-value: 3.26e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133  49 STAEDKDQRYRRLALKHHPLKS-NEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGiplefgsqtpwTTGYVFH 127
Cdd:PRK14289  17 ATVDEIKKAYRKKAIQYHPDKNpGDKEAEEKFKEAAEAYDVLSDPDKRSRYDQFGHAGVGGA-----------AGGGGFS 85

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767968133 128 GKP---EKVFHEF---FGGNN-PFSEFFdaegsevdlNFGGLQGRGVKKQDPQVERDLYLSLEDLFFGCTKKIKISRRV 199
Cdd:PRK14289  86 GEGmsmEDIFSMFgdiFGGHGgGFGGFG---------GFGGGGSQQRVFRGSDLRVKVKLNLKEISTGVEKKFKVKKYV 155
PRK14288 PRK14288
molecular chaperone DnaJ;
47-214 3.43e-14

molecular chaperone DnaJ;


Pssm-ID: 172776 [Multi-domain]  Cd Length: 369  Bit Score: 70.87  E-value: 3.43e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133  47 EHSTAEDKDQRYRRLALKHHPLK-SNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLkggiplefgsqtpwttgyv 125
Cdd:PRK14288  13 KHSNQETIKKSYRKLALKYHPDRnAGDKEAEEKFKLINEAYGVLSDEKKRALYDRYGKKGL------------------- 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133 126 fhgkpekvfHEFFGGNNPFSEFFDAEGSEVDLNFgGLQGRGVKKQDPQVERD----LYLSLEDLFFGCTKKIKISRRVLN 201
Cdd:PRK14288  74 ---------NQAGASQSDFSDFFEDLGSFFEDAF-GFGARGSKRQKSSIAPDylqtIELSFKEAVFGCKKTIKVQYQSVC 143

                        170
                 ....*....|...
gi 767968133 202 EDGYSSTIKDKIL 214
Cdd:PRK14288 144 ESCDGTGAKDKAL 156
PRK14295 PRK14295
molecular chaperone DnaJ;
49-196 7.73e-14

molecular chaperone DnaJ;


Pssm-ID: 237665 [Multi-domain]  Cd Length: 389  Bit Score: 69.88  E-value: 7.73e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133  49 STAEDKDQRYRRLALKHHP-LKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDK----FGEEGLKGGIPLEFGSQTPWTTG 123
Cdd:PRK14295  21 ATEAEIKKAYRKLAREYHPdANKGDAKAEERFKEISEAYDVLSDEKKRKEYDEarslFGNGGFRPGPGGGGGGGFNFDLG 100

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767968133 124 yvfhgkpekvfhEFFGGNNPFSEFFDAEGSEVDLnFGGLQGRGVKKQDPQ----VERDLYLSLEDLFFGCTKKIKIS 196
Cdd:PRK14295 101 ------------DLFGGGAQGGGGAGGGGGLGDV-FGGLFNRGGRRTQPRrgadVESEVTLSFTEAIDGATVPLRLT 164
PRK14292 PRK14292
chaperone protein DnaJ; Provisional
 49-183 1.81e-13

chaperone protein DnaJ; Provisional


Pssm-ID: 237662 [Multi-domain]  Cd Length: 371  Bit Score: 68.76  E-value: 1.81e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133  49 STAEDKDQRYRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEE---GLKGGIPleFGsqtpwttGYV 125
Cdd:PRK14292  14 ASADEIKSAYRKLALKYHPDRNKEKGAAEKFAQINEAYAVLSDAEKRAHYDRFGTApgaGMPGGDP--FG-------GMG 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767968133 126 FhgKPEKVFHEFFGGnnpfseffdaegsevdLNFGGLQGRGVKKQDPQVERDLYLSLE 183
Cdd:PRK14292  85 F--DPMDIFEQLFGG----------------AGFGGGRGRRGPARGDDLETEARITLE 124
PRK14281 PRK14281
chaperone protein DnaJ; Provisional
 49-199 2.29e-13

chaperone protein DnaJ; Provisional


Pssm-ID: 237657 [Multi-domain]  Cd Length: 397  Bit Score: 68.68  E-value: 2.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133  49 STAEDKDQ---RYRRLALKHHPLKSNEPSSAE-IFRQIAEAYDVLSDPMKRGIYDKFGEEGLkgGIPLEFGSQTPWTTGY 124
Cdd:PRK14281  12 SRSADKDEikkAYRKLALKYHPDKNPDNKEAEeHFKEVNEAYEVLSNDDKRRRYDQFGHAGV--GSSAASGGGPGYGGGG 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133 125 VFHGKPEKVFHEFFGGNNPFSEFFDAEGSEVdlnFGGLQGR-----GVKKQDPQVErdLYLSLEDLFFGCTKKIKISRRV 199
Cdd:PRK14281  90 GDFNDIFSAFNDMFGGGARRGGGSPFGFEDV---FGGGGRRrrasaGIPGTDLKIR--LKLTLEEIAKGVEKTLKIKKQV 164
PRK14278 PRK14278
chaperone protein DnaJ; Provisional
 58-200 3.72e-13

chaperone protein DnaJ; Provisional


Pssm-ID: 237654 [Multi-domain]  Cd Length: 378  Bit Score: 68.16  E-value: 3.72e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133  58 YRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDkfgeeglKGGIPLEFGSQTPWTTGYVFHGKPEkVFHEF 137
Cdd:PRK14278  24 YRKLARELHPDVNPDEEAQEKFKEISVAYEVLSDPEKRRIVD-------LGGDPLESAGGGGGGFGGGFGGLGD-VFEAF 95

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767968133 138 FGGnnpfseffdAEGSEvdlnfgGLQGRGVKKQDPQVErdLYLSLEDLFFGCTKKIKISRRVL 200
Cdd:PRK14278  96 FGG---------GAASR------GPRGRVRPGSDSLLR--MRLDLEECATGVTKQVTVDTAVL 141
PRK14284 PRK14284
chaperone protein DnaJ; Provisional
 49-196 7.10e-13

chaperone protein DnaJ; Provisional


Pssm-ID: 237658 [Multi-domain]  Cd Length: 391  Bit Score: 67.18  E-value: 7.10e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133  49 STAEDKDQRYRRLALKHHPLKSNEPSSAEI-FRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGIPLeFGSQtpwttGYVFH 127
Cdd:PRK14284  13 ASPEEIKKAYRKLAVKYHPDKNPGDAEAEKrFKEVSEAYEVLSDAQKRESYDRYGKDGPFAGAGG-FGGA-----GMGNM 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133 128 GKPEKVFHEFFGGNNPFSE-FFDAEGSEVDLNFGGLQGRGVKKQDPQVERDLYLSLEDLFFGCTKKIKIS 196
Cdd:PRK14284  87 EDALRTFMGAFGGEFGGGGsFFEGLFGGLGEAFGMRGGPAGARQGASKKVHITLSFEEAAKGVEKELLVS 156
DnaJ smart00271
DnaJ molecular chaperone homology domain;
47-94 4.54e-12

DnaJ molecular chaperone homology domain;


Pssm-ID: 197617 [Multi-domain]  Cd Length: 60  Bit Score: 59.56  E-value: 4.54e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 767968133    47 EHSTAEDKDQRYRRLALKHHP--LKSNEPSSAEIFRQIAEAYDVLSDPMK 94
Cdd:smart00271  11 RDASLDEIKKAYRKLALKYHPdkNPGDKEEAEEKFKEINEAYEVLSDPEK 60
PRK14287 PRK14287
chaperone protein DnaJ; Provisional
 47-197 4.73e-12

chaperone protein DnaJ; Provisional


Pssm-ID: 237659 [Multi-domain]  Cd Length: 371  Bit Score: 64.65  E-value: 4.73e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133  47 EHSTAEDKDQRYRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGE----EGLKGGIPLEFGsqtpwtt 122
Cdd:PRK14287  14 RNASVDEVKKAYRKLARKYHPDVNKAPDAEDKFKEVKEAYDTLSDPQKKAHYDQFGHtdpnQGFGGGGAGDFG------- 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767968133 123 GYvfhgkpEKVFHEFFGGNnpfseffdaegsevdlnfGGLQGRGVKKQDPQVERDLYLSLEDLFFGCTKKIKISR 197
Cdd:PRK14287  87 GF------SDIFDMFFGGG------------------GGRRNPNAPRQGADLQYTMTLEFKEAVFGKETEIEIPR 137
PRK14279 PRK14279
molecular chaperone DnaJ;
48-172 9.24e-12

molecular chaperone DnaJ;


Pssm-ID: 237655 [Multi-domain]  Cd Length: 392  Bit Score: 63.98  E-value: 9.24e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133  48 HSTAEDKDQRYRRLALKHHPLKS-NEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGIPLEFGSQTPWTTGYVF 126
Cdd:PRK14279  20 DASAEEIKKAYRKLARELHPDANpGDPAAEERFKAVSEAHDVLSDPAKRKEYDETRRLFAGGGFGGRRFDGGGGFGGFGT 99

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 767968133 127 HGKpekvfheffGGNNPFSEFFDAEGSEVDLN----FGGLQGRGVKKQDP 172
Cdd:PRK14279 100 GGD---------GAEFNLNDLFDAAGRGGGGGigdlFGGLFNRGGGSARP 140
PRK14296 PRK14296
chaperone protein DnaJ; Provisional
 49-195 1.13e-11

chaperone protein DnaJ; Provisional


Pssm-ID: 237666 [Multi-domain]  Cd Length: 372  Bit Score: 63.81  E-value: 1.13e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133  49 STAEDKDQRYRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGIplEFGSQtpwttgyvFHG 128
Cdd:PRK14296  16 ASEQEIRQAYRKLAKQYHPDLNKSPDAHDKMVEINEAADVLLDKDKRKQYDQFGHAAFDGSS--GFSSN--------FGD 85

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767968133 129 kpekvFHEFF------GG---NNPFSEFFDAEGSEvdlnfgglQGRGVKKQDpqVERDLYLSLEDLFFGCTKKIKI 195
Cdd:PRK14296  86 -----FEDLFsnmgssGFssfTNIFSDFFGSNKSD--------YQRSTKGQS--VSLDIYLTFKELLFGVDKIIEL 146
PRK14282 PRK14282
chaperone protein DnaJ; Provisional
 49-197 1.41e-11

chaperone protein DnaJ; Provisional


Pssm-ID: 184603 [Multi-domain]  Cd Length: 369  Bit Score: 63.27  E-value: 1.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133  49 STAEDKDQRYRRLALKHHPLK--SNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGlkGGIPlefgSQTPWTTGYVF 126
Cdd:PRK14282  16 ATQEEIKRAYKRLVKEWHPDRhpENRKEAEQKFKEIQEAYEVLSDPQKRAMYDRFGYVG--EQPP----YQETESGGGFF 89

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767968133 127 hgkpEKVFHEF--FGGNNPFSEFFDAEGSEVdlnfgglQGRGVKKQDPQVERDLYLSLEDLFFGCTKKIKISR 197
Cdd:PRK14282  90 ----EDIFKDFenIFNRDIFDIFFGERRTQE-------EQREYARRGEDIRYEIEVTLSDLINGAEIPVEYDR 151
PRK10266 PRK10266
curved DNA-binding protein;
58-234 1.71e-11

curved DNA-binding protein;


Pssm-ID: 182347 [Multi-domain]  Cd Length: 306  Bit Score: 62.92  E-value: 1.71e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133  58 YRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGipleFGSQTPWTTGYVFHGkpekvfHEF 137
Cdd:PRK10266  25 YRRLARKYHPDVSKEPDAEARFKEVAEAWEVLSDEQRRAEYDQLWQHRNDPQ----FNRQFQHGDGQSFNA------EDF 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133 138 fggNNPFSEFFDAEGSEVDlnfgglQGRGVKKQDPQVERDLYlsLEDLFFGCTKKIKISRRVLNEDGYSSTIKDKILTID 217
Cdd:PRK10266  95 ---DDIFSSIFGQHARQSR------QRPAARGHDIEIEVAVF--LEETLTEHKRTISYNLPVYNAFGMIEQEIPKTLNVK 163

                        170
                 ....*....|....*..
gi 767968133 218 VKPGWRQGTRITFEKEG 234
Cdd:PRK10266 164 IPAGVGNGQRIRLKGQG 180
CbpA COG2214
Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];
50-121 1.93e-11

Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];


Pssm-ID: 441816 [Multi-domain]  Cd Length: 91  Bit Score: 58.58  E-value: 1.93e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767968133  50 TAEDKDQRYRRLALKHHPLKSNEP--SSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGIPLEFGSQTPWT 121
Cdd:COG2214   18 SLEEIRQAYRRLAKLLHPDRGGELkaLAEELFQRLNEAYEVLSDPERRAEYDRELGQSGKGSASQPSAAAQRLA 91
PRK14301 PRK14301
chaperone protein DnaJ; Provisional
 49-109 3.76e-11

chaperone protein DnaJ; Provisional


Pssm-ID: 237668 [Multi-domain]  Cd Length: 373  Bit Score: 62.07  E-value: 3.76e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767968133  49 STAEDKDQR-YRRLALKHHPLKS-NEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGG 109
Cdd:PRK14301  15 DASEDEIKKaYRKLALQYHPDRNpDNPEAEQKFKEAAEAYEVLRDAEKRARYDRFGHAGVNGN 77
DnaJ cd06257
DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and ...
 47-91 3.82e-10

DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonine family. Hsp40 proteins are characterized by the presence of a J domain, which mediates the interaction with Hsp70. They may contain other domains as well, and the architectures provide a means of classification.


Pssm-ID: 99751 [Multi-domain]  Cd Length: 55  Bit Score: 54.09  E-value: 3.82e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 767968133  47 EHSTAEDKDQRYRRLALKHHPLK-SNEPSSAEIFRQIAEAYDVLSD 91
Cdd:cd06257   10 PDASDEEIKKAYRKLALKYHPDKnPDDPEAEEKFKEINEAYEVLSD 55
PRK14300 PRK14300
chaperone protein DnaJ; Provisional
 49-199 2.67e-09

chaperone protein DnaJ; Provisional


Pssm-ID: 172788 [Multi-domain]  Cd Length: 372  Bit Score: 56.56  E-value: 2.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133  49 STAEDKDQRYRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGIPLEFGSQTPWttgyvFHG 128
Cdd:PRK14300  15 ASQADLKKAYLKLAKQYHPDTTDAKDAEKKFKEINAAYDVLKDEQKRAAYDRFGHDAFQNQQSRGGGGNHGG-----FHP 89

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767968133 129 KPEKVFHEFfggnnpFSEFFDaegsevdlnfGGLQGR--GVKKQDPQVERDLYLSLEDLFFGCTKKIKISRRV 199
Cdd:PRK14300  90 DINDIFGDF------FSDFMG----------GSRRSRptSSKVRGSDLKYNLTINLEEAFHGIEKNISFSSEV 146
DnaJ_C pfam01556
DnaJ C terminal domain; This family consists of the C terminal region of the DnaJ protein. It ...
 174-235 5.08e-09

DnaJ C terminal domain; This family consists of the C terminal region of the DnaJ protein. It is always found associated with pfam00226 and pfam00684. DnaJ is a chaperone associated with the Hsp70 heat-shock system involved in protein folding and renaturation after stress. The two C-terminal domains CTDI and CTDII, both incorporated in this family are necessary for maintaining the J-domains in their specific relative positions. Structural analysis of PDB:1nlt shows that PF00684 is nested within this DnaJ C-terminal region.


Pssm-ID: 460251 [Multi-domain]  Cd Length: 213  Bit Score: 54.57  E-value: 5.08e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968133  174 VERDLYLSLEDLFFGCTKKIKISRRVLNED-------------------------------------------------- 203
Cdd:pfam01556   1 LEYELELTLEEAYFGCTKKIKITRNVICDTcggsgakpgtspktcpccggggqvrrqfgffstctccpccggggkiidkc 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 767968133  204 ----GYSSTIKDKILTIDVKPGWRQGTRITFEKEGD 235
Cdd:pfam01556  81 ckccGGGGVVEKKTLEVKIPAGVDDGQRIRLRGEGD 116
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
 37-108 2.54e-08

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 54.02  E-value: 2.54e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767968133   37 LLDRGVNIHLEHSTaedkdQRYRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKG 108
Cdd:PTZ00341  578 ILGVGVNADMKEIS-----ERYFKLAENYYPPKRSGNEGFHKFKKINEAYQILGDIDKKKMYNKFGYDGIKG 644
DjlA COG1076
DnaJ domain-containing protein [Posttranslational modification, protein turnover, chaperones];
55-97 1.24e-03

DnaJ domain-containing protein [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440694 [Multi-domain]  Cd Length: 75  Bit Score: 36.70  E-value: 1.24e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 767968133  55 DQRYRRLALKHHP--LKSNEPSSA-----EIFRQIAEAYDVLSDPmkRGI 97
Cdd:COG1076   22 KRAYRKLQREHHPdrLAAGLPEEEqrlalQKAAAINEAYETLKDP--RGI 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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