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Conserved domains on  [gi|829933536|ref|XP_012596509|]
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NF-kappa-B inhibitor-like protein 1 isoform X1 [Microcebus murinus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
28-124 2.08e-10

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.12  E-value: 2.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829933536  28 SSGRLVRAQALLQRhpGLDV---DAGQPPPLHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQGpdaYTDFFL 104
Cdd:COG0666   96 RNGDLEIVKLLLEA--GADVnarDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANG---NLEIVK 170

                         90       100
                 ....*....|....*....|....
gi 829933536 105 PLLSRcpsamG----IKNKDGETP 124
Cdd:COG0666  171 LLLEA-----GadvnARDNDGETP 189
PTZ00121 super family cl31754
MAEBL; Provisional
 154-274 1.65e-04

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.98  E-value: 1.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829933536  154 KLQDELEAE-WQEGMGRFEddasrETQEPESFSAWSDRLAEEHAQKRQQQREAEgscRPPRAEGSRHSWRQQEEEQRLFL 232
Cdd:PTZ00121 1083 AKEDNRADEaTEEAFGKAE-----EAKKTETGKAEEARKAEEAKKKAEDARKAE---EARKAEDARKAEEARKAEDAKRV 1154

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 829933536  233 ERARAKEEELRESRARRAQEAQGDQGPEPARARPRAEHPRGA 274
Cdd:PTZ00121 1155 EIARKAEDARKAEEARKAEDAKKAEAARKAEEVRKAEELRKA 1196
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
28-124 2.08e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.12  E-value: 2.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829933536  28 SSGRLVRAQALLQRhpGLDV---DAGQPPPLHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQGpdaYTDFFL 104
Cdd:COG0666   96 RNGDLEIVKLLLEA--GADVnarDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANG---NLEIVK 170

                         90       100
                 ....*....|....*....|....
gi 829933536 105 PLLSRcpsamG----IKNKDGETP 124
Cdd:COG0666  171 LLLEA-----GadvnARDNDGETP 189
Ank_2 pfam12796
Ankyrin repeats (3 copies);
55-95 1.93e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 45.49  E-value: 1.93e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 829933536   55 LHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQG 95
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNG 41
PTZ00121 PTZ00121
MAEBL; Provisional
 154-274 1.65e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.98  E-value: 1.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829933536  154 KLQDELEAE-WQEGMGRFEddasrETQEPESFSAWSDRLAEEHAQKRQQQREAEgscRPPRAEGSRHSWRQQEEEQRLFL 232
Cdd:PTZ00121 1083 AKEDNRADEaTEEAFGKAE-----EAKKTETGKAEEARKAEEAKKKAEDARKAE---EARKAEDARKAEEARKAEDAKRV 1154

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 829933536  233 ERARAKEEELRESRARRAQEAQGDQGPEPARARPRAEHPRGA 274
Cdd:PTZ00121 1155 EIARKAEDARKAEEARKAEDAKKAEAARKAEEVRKAEELRKA 1196
DDRGK pfam09756
DDRGK domain; This is a family of proteins of approximately 300 residues, found in plants and ...
 190-253 1.98e-04

DDRGK domain; This is a family of proteins of approximately 300 residues, found in plants and vertebrates. They contain a highly conserved DDRGK motif.


Pssm-ID: 370664 [Multi-domain]  Cd Length: 188  Bit Score: 41.95  E-value: 1.98e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 829933536  190 RLAEEHAQKRQQQREAEGSCRPPRA--EGSRHSWRQQEEEQRLFLERARAKEEEL-RESRARRAQEA 253
Cdd:pfam09756   8 RAKLELKEAKRQQREAEEEEREEREklEEKREEEYKEREEREEEAEKEKEEEERKqEEEQERKEQEE 74
PHA03095 PHA03095
ankyrin-like protein; Provisional
 44-118 6.26e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 38.47  E-value: 6.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829933536  44 GLDVDA----GQPPpLHRAcARHDAPALCL-LLRLGADPAHQDRHGDTALHAAARQGpdaYTDFFLPLLSRCPSAMGIKN 118
Cdd:PHA03095 247 GISINArnryGQTP-LHYA-AVFNNPRACRrLIALGADINAVSSDGNTPLSLMVRNN---NGRAVRAALAKNPSAETVAA 321
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
28-124 2.08e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.12  E-value: 2.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829933536  28 SSGRLVRAQALLQRhpGLDV---DAGQPPPLHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQGpdaYTDFFL 104
Cdd:COG0666   96 RNGDLEIVKLLLEA--GADVnarDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANG---NLEIVK 170

                         90       100
                 ....*....|....*....|....
gi 829933536 105 PLLSRcpsamG----IKNKDGETP 124
Cdd:COG0666  171 LLLEA-----GadvnARDNDGETP 189
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
30-124 2.72e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 60.74  E-value: 2.72e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829933536  30 GRLVRAQALLQRhpGLDVDA---GQPPPLHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQGpdaYTDFFLPL 106
Cdd:COG0666  131 GNLEIVKLLLEA--GADVNAqdnDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENG---HLEIVKLL 205

                         90       100
                 ....*....|....*....|..
gi 829933536 107 LSRcpsamG----IKNKDGETP 124
Cdd:COG0666  206 LEA-----GadvnAKDNDGKTA 222
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
32-124 6.27e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 53.42  E-value: 6.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829933536  32 LVRAQALLQRHPGLDVDAGQPPPLHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQGPDAYTDFFLpllsrcp 111
Cdd:COG0666   68 LVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL------- 140

                         90
                 ....*....|....*..
gi 829933536 112 sAMG----IKNKDGETP 124
Cdd:COG0666  141 -EAGadvnAQDNDGNTP 156
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
35-95 6.62e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 53.42  E-value: 6.62e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 829933536  35 AQALLQRhpGLDVDAGQP---PPLHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQG 95
Cdd:COG0666  169 VKLLLEA--GADVNARDNdgeTPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENG 230
Ank_2 pfam12796
Ankyrin repeats (3 copies);
55-95 1.93e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 45.49  E-value: 1.93e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 829933536   55 LHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQG 95
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNG 41
Ank_4 pfam13637
Ankyrin repeats (many copies);
53-95 2.53e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.49  E-value: 2.53e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 829933536   53 PPLHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQG 95
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNG 45
PTZ00121 PTZ00121
MAEBL; Provisional
 154-274 1.65e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.98  E-value: 1.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829933536  154 KLQDELEAE-WQEGMGRFEddasrETQEPESFSAWSDRLAEEHAQKRQQQREAEgscRPPRAEGSRHSWRQQEEEQRLFL 232
Cdd:PTZ00121 1083 AKEDNRADEaTEEAFGKAE-----EAKKTETGKAEEARKAEEAKKKAEDARKAE---EARKAEDARKAEEARKAEDAKRV 1154

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 829933536  233 ERARAKEEELRESRARRAQEAQGDQGPEPARARPRAEHPRGA 274
Cdd:PTZ00121 1155 EIARKAEDARKAEEARKAEDAKKAEAARKAEEVRKAEELRKA 1196
DDRGK pfam09756
DDRGK domain; This is a family of proteins of approximately 300 residues, found in plants and ...
 190-253 1.98e-04

DDRGK domain; This is a family of proteins of approximately 300 residues, found in plants and vertebrates. They contain a highly conserved DDRGK motif.


Pssm-ID: 370664 [Multi-domain]  Cd Length: 188  Bit Score: 41.95  E-value: 1.98e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 829933536  190 RLAEEHAQKRQQQREAEGSCRPPRA--EGSRHSWRQQEEEQRLFLERARAKEEEL-RESRARRAQEA 253
Cdd:pfam09756   8 RAKLELKEAKRQQREAEEEEREEREklEEKREEEYKEREEREEEAEKEKEEEERKqEEEQERKEQEE 74
PTZ00121 PTZ00121
MAEBL; Provisional
 158-274 2.03e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.51  E-value: 2.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829933536  158 ELEAEWQEGMGRFED----DASRETQE----PESFSAWSDRLAE-----EHAQKRQQQREAEGSCRPP---RAEGSRHSW 221
Cdd:PTZ00121 1112 EEARKAEEAKKKAEDarkaEEARKAEDarkaEEARKAEDAKRVEiarkaEDARKAEEARKAEDAKKAEaarKAEEVRKAE 1191

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 829933536  222 --RQQEEEQRLflERARAKEEELRESRARRAQEAQGDQGPEPA-RARPRAEHPRGA 274
Cdd:PTZ00121 1192 elRKAEDARKA--EAARKAEEERKAEEARKAEDAKKAEAVKKAeEAKKDAEEAKKA 1245
Ank_5 pfam13857
Ankyrin repeats (many copies);
54-91 2.65e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.79  E-value: 2.65e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 829933536   54 PLHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAA 91
Cdd:pfam13857  19 PLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PTZ00121 PTZ00121
MAEBL; Provisional
 154-274 3.30e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.74  E-value: 3.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829933536  154 KLQDELEAEWQEGMGRFEDDASRETQEPESFSAWSDRLAEEHAQKRQQQREAEgSCRPPRAEGSRHS--WRQQEEEQRLF 231
Cdd:PTZ00121 1653 KKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAE-ELKKKEAEEKKKAeeLKKAEEENKIK 1731

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 829933536  232 LERARAKEEELResraRRAQEAQGDQGPEPARARPRAEHPRGA 274
Cdd:PTZ00121 1732 AEEAKKEAEEDK----KKAEEAKKDEEEKKKIAHLKKEEEKKA 1770
PHA03095 PHA03095
ankyrin-like protein; Provisional
 44-118 6.26e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 38.47  E-value: 6.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829933536  44 GLDVDA----GQPPpLHRAcARHDAPALCL-LLRLGADPAHQDRHGDTALHAAARQGpdaYTDFFLPLLSRCPSAMGIKN 118
Cdd:PHA03095 247 GISINArnryGQTP-LHYA-AVFNNPRACRrLIALGADINAVSSDGNTPLSLMVRNN---NGRAVRAALAKNPSAETVAA 321
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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