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Conserved domains on  [gi|926492597|ref|XP_013817706|]
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PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 4 [Apteryx mantelli mantelli]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 77-238 1.76e-80

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


:

Pssm-ID: 239801  Cd Length: 207  Bit Score: 251.00  E-value: 1.76e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926492597  77 LLVTRLVVLGEGTPGPPVTSNAAQMLRNFCEWQKDLNDPDEDSPQHFDTAILFTRQDLCGAA-TCNTLGMADVGTVCNPT 155
Cdd:cd04273   48 IVVVRLIVLEDEESGLLISGNAQKSLKSFCRWQKKLNPPNDSDPEHHDHAILLTRQDICRSNgNCDTLGLAPVGGMCSPS 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926492597 156 RSCSIVEDDGLQSAFTAAHELGHVFNMLHDDS-KPCEElnrhSGASRHMMAPVMSSVDPEETWSPCSARFITDFLDNGHG 234
Cdd:cd04273  128 RSCSINEDTGLSSAFTIAHELGHVLGMPHDGDgNSCGP----EGKDGHIMSPTLGANTGPFTWSKCSRRYLTSFLDTGDG 203


                 ....
gi 926492597 235 HCLL 238
Cdd:cd04273  204 NCLL 207
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 252-320 3.96e-22

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


:

Pssm-ID: 465496  Cd Length: 68  Bit Score: 90.10  E-value: 3.96e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926492597  252 PGSVYDADRQCQLTFGSESRHC-AGPQPPCASLWCTGhaNGRSMCQTKHFPWADGTPCGSGKTCRNGLCV 320
Cdd:pfam17771   1 PGQLYSADEQCRLIFGPGSTFCpNGDEDVCSKLWCSN--PGGSTCTTKNLPAADGTPCGNKKWCLNGKCV 68
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 335-382 1.21e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 56.83  E-value: 1.21e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 926492597   335 GPWAP-SRSCGGGVRFSRRECVKPAPRNGGKYCEGKRTQFRSCNVDACP 382
Cdd:smart00209   5 SEWSPcSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
ADAMTS_spacer1 super family cl20316
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 16-69 1.97e-09

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


The actual alignment was detected with superfamily member pfam05986:

Pssm-ID: 461796  Cd Length: 115  Bit Score: 55.28  E-value: 1.97e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 926492597   16 VVTIPAGATHILIRQISAAGSgsddvFLALRRPDGTSLLNGNYVLVPSETDVKL 69
Cdd:pfam05986  17 FVTIPAGATHIHIVNRKPSFT-----HLAVKNVQGKYILNGKGSISLNPTYPSL 65
ADAMTS_spacer1 super family cl20316
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 494-523 1.23e-07

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


The actual alignment was detected with superfamily member pfam05986:

Pssm-ID: 461796  Cd Length: 115  Bit Score: 50.27  E-value: 1.23e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 926492597  494 KIYGSFAKAR-YGYNDVVTIPAGATHILIRQ 523
Cdd:pfam05986   1 TVSGSFTEGRaKGYVTFVTIPAGATHIHIVN 31
ADAMTS_CR_3 super family cl41950
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 387-492 5.08e-06

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


The actual alignment was detected with superfamily member pfam19236:

Pssm-ID: 437068  Cd Length: 115  Bit Score: 45.86  E-value: 5.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926492597  387 LAFREQQCAAYN---YRSDlfKGFPAPMDW---VPRYSGVAekdQCKLTCQSEALGYYHVLEPRVVDGTPCSPE------ 454
Cdd:pfam19236   3 LEFMSQQCARTDgqpLRSS--PGGASFYHWgaaVPHSQGDA---LCRHMCRAIGESFIMKRGDSFLDGTRCMPSgpredg 77

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 926492597  455 STSVCVQGRCIPAGCDRVIGSKKKFDKCMKCGGDGSSC 492
Cdd:pfam19236  78 TLSLCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
 
Name Accession Description Interval E-value
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 77-238 1.76e-80

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


Pssm-ID: 239801  Cd Length: 207  Bit Score: 251.00  E-value: 1.76e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926492597  77 LLVTRLVVLGEGTPGPPVTSNAAQMLRNFCEWQKDLNDPDEDSPQHFDTAILFTRQDLCGAA-TCNTLGMADVGTVCNPT 155
Cdd:cd04273   48 IVVVRLIVLEDEESGLLISGNAQKSLKSFCRWQKKLNPPNDSDPEHHDHAILLTRQDICRSNgNCDTLGLAPVGGMCSPS 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926492597 156 RSCSIVEDDGLQSAFTAAHELGHVFNMLHDDS-KPCEElnrhSGASRHMMAPVMSSVDPEETWSPCSARFITDFLDNGHG 234
Cdd:cd04273  128 RSCSINEDTGLSSAFTIAHELGHVLGMPHDGDgNSCGP----EGKDGHIMSPTLGANTGPFTWSKCSRRYLTSFLDTGDG 203


                 ....
gi 926492597 235 HCLL 238
Cdd:cd04273  204 NCLL 207
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 252-320 3.96e-22

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 90.10  E-value: 3.96e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926492597  252 PGSVYDADRQCQLTFGSESRHC-AGPQPPCASLWCTGhaNGRSMCQTKHFPWADGTPCGSGKTCRNGLCV 320
Cdd:pfam17771   1 PGQLYSADEQCRLIFGPGSTFCpNGDEDVCSKLWCSN--PGGSTCTTKNLPAADGTPCGNKKWCLNGKCV 68
Reprolysin pfam01421
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ...
 93-241 2.57e-16

Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.


Pssm-ID: 426256 [Multi-domain]  Cd Length: 200  Bit Score: 77.73  E-value: 2.57e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926492597   93 PVTSNAAQMLRNFCEWQKDLNDPdedsPQHFDTAILFTRQDLCGaatcNTLGMADVGTVCNPTRSCSIVED---DGLQSA 169
Cdd:pfam01421  61 DVSGDANDTLRNFLKWRQEYLKK----RKPHDVAQLLSGVEFGG----TTVGAAYVGGMCSLEYSGGVNEDhskNLESFA 132

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 926492597  170 FTAAHELGHVFNMLHDDSKP---CEElnrhsgASRHMMAPVMSSVDPEEtWSPCSARFITDFLDNGHGHCLLDKP 241
Cdd:pfam01421 133 VTMAHELGHNLGMQHDDFNGgckCPP------GGGCIMNPSAGSSFPRK-FSNCSQEDFEQFLTKQKGACLFNKP 200
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 335-382 1.21e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 56.83  E-value: 1.21e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 926492597   335 GPWAP-SRSCGGGVRFSRRECVKPAPRNGGKYCEGKRTQFRSCNVDACP 382
Cdd:smart00209   5 SEWSPcSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 16-69 1.97e-09

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 55.28  E-value: 1.97e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 926492597   16 VVTIPAGATHILIRQISAAGSgsddvFLALRRPDGTSLLNGNYVLVPSETDVKL 69
Cdd:pfam05986  17 FVTIPAGATHIHIVNRKPSFT-----HLAVKNVQGKYILNGKGSISLNPTYPSL 65
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 494-523 1.23e-07

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 50.27  E-value: 1.23e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 926492597  494 KIYGSFAKAR-YGYNDVVTIPAGATHILIRQ 523
Cdd:pfam05986   1 TVSGSFTEGRaKGYVTFVTIPAGATHIHIVN 31
ACR smart00608
ADAM Cysteine-Rich Domain;
251-322 4.66e-06

ADAM Cysteine-Rich Domain;


Pssm-ID: 214743  Cd Length: 137  Bit Score: 46.20  E-value: 4.66e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926492597   251 LPGSVYDADRQCQLTFGSESR------------------HC---AGPQPPCAS-------LWCTG--------------- 287
Cdd:smart00608  14 YNGRCPTRDNQCQALFGPGAKvapdscyeelntkgdrfgNCgreNGTYIPCAPedvkcgkLQCTNvselpllgehatviy 93

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 926492597   288 HANGRSMCQTKHFP---------WADGTPCGSGKTCRNGLCVGH 322
Cdd:smart00608  94 SNIGGLVCWSLDYHlgtdpdigmVKDGTKCGPGKVCINGQCVDV 137
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 387-492 5.08e-06

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 45.86  E-value: 5.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926492597  387 LAFREQQCAAYN---YRSDlfKGFPAPMDW---VPRYSGVAekdQCKLTCQSEALGYYHVLEPRVVDGTPCSPE------ 454
Cdd:pfam19236   3 LEFMSQQCARTDgqpLRSS--PGGASFYHWgaaVPHSQGDA---LCRHMCRAIGESFIMKRGDSFLDGTRCMPSgpredg 77

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 926492597  455 STSVCVQGRCIPAGCDRVIGSKKKFDKCMKCGGDGSSC 492
Cdd:pfam19236  78 TLSLCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 334-381 8.11e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 34.74  E-value: 8.11e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 926492597  334 VGPWAP-SRSCGGGVRFSRRECVKPAPR--NGGKYCEGKR--TQFRSCNVDAC 381
Cdd:pfam19030   3 AGPWGEcSVTCGGGVQTRLVQCVQKGGGsiVPDSECSAQKkpPETQSCNLKPC 55
 
Name Accession Description Interval E-value
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 77-238 1.76e-80

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


Pssm-ID: 239801  Cd Length: 207  Bit Score: 251.00  E-value: 1.76e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926492597  77 LLVTRLVVLGEGTPGPPVTSNAAQMLRNFCEWQKDLNDPDEDSPQHFDTAILFTRQDLCGAA-TCNTLGMADVGTVCNPT 155
Cdd:cd04273   48 IVVVRLIVLEDEESGLLISGNAQKSLKSFCRWQKKLNPPNDSDPEHHDHAILLTRQDICRSNgNCDTLGLAPVGGMCSPS 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926492597 156 RSCSIVEDDGLQSAFTAAHELGHVFNMLHDDS-KPCEElnrhSGASRHMMAPVMSSVDPEETWSPCSARFITDFLDNGHG 234
Cdd:cd04273  128 RSCSINEDTGLSSAFTIAHELGHVLGMPHDGDgNSCGP----EGKDGHIMSPTLGANTGPFTWSKCSRRYLTSFLDTGDG 203


                 ....
gi 926492597 235 HCLL 238
Cdd:cd04273  204 NCLL 207
ZnMc_ADAM_like cd04267
Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ...
 76-230 9.61e-32

Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ADAM family of metalloproteases contains proteolytic domains from snake venoms, proteases from the mammalian reproductive tract, and the tumor necrosis factor alpha convertase, TACE. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239795  Cd Length: 192  Bit Score: 121.37  E-value: 9.61e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926492597  76 GLLVTRLVVLGEGTPGPPVTSNAAQMLRNFCEWQkdlndpdEDSPQHFDTAILFTRQDLCGaatCNTLGMADVGTVCNPT 155
Cdd:cd04267   49 RISLEGLQILKGEQFAPPIDSDASNTLNSFSFWR-------AEGPIRHDNAVLLTAQDFIE---GDILGLAYVGSMCNPY 118

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 926492597 156 RSCSIVEDDG--LQSAFTAAHELGHVFNMLHDDSKPCEELNRhsGASRHMMAPVMSSVDPEEtWSPCSARFITDFLD 230
Cdd:cd04267  119 SSVGVVEDTGftLLTALTMAHELGHNLGAEHDGGDELAFECD--GGGNYIMAPVDSGLNSYR-FSQCSIGSIREFLD 192
ZnMc_adamalysin_II_like cd04269
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom ...
 93-239 4.46e-24

Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239797 [Multi-domain]  Cd Length: 194  Bit Score: 99.61  E-value: 4.46e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926492597  93 PVTSNAAQMLRNFCEW-QKDLNDPdedspQHFDTAILFTRQDLCGaatcNTLGMADVGTVCNPTRSCSIVEDDG---LQS 168
Cdd:cd04269   61 SVSGDAGETLNRFLDWkRSNLLPR-----KPHDNAQLLTGRDFDG----NTVGLAYVGGMCSPKYSGGVVQDHSrnlLLF 131

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 926492597 169 AFTAAHELGHVFNMLHDDSKpCeelnrHSGASRHMMAPvmSSVDPEETWSPCSARFITDFLDNGHGHCLLD 239
Cdd:cd04269  132 AVTMAHELGHNLGMEHDDGG-C-----TCGRSTCIMAP--SPSSLTDAFSNCSYEDYQKFLSRGGGQCLLN 194
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 252-320 3.96e-22

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 90.10  E-value: 3.96e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926492597  252 PGSVYDADRQCQLTFGSESRHC-AGPQPPCASLWCTGhaNGRSMCQTKHFPWADGTPCGSGKTCRNGLCV 320
Cdd:pfam17771   1 PGQLYSADEQCRLIFGPGSTFCpNGDEDVCSKLWCSN--PGGSTCTTKNLPAADGTPCGNKKWCLNGKCV 68
Reprolysin pfam01421
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ...
 93-241 2.57e-16

Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.


Pssm-ID: 426256 [Multi-domain]  Cd Length: 200  Bit Score: 77.73  E-value: 2.57e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926492597   93 PVTSNAAQMLRNFCEWQKDLNDPdedsPQHFDTAILFTRQDLCGaatcNTLGMADVGTVCNPTRSCSIVED---DGLQSA 169
Cdd:pfam01421  61 DVSGDANDTLRNFLKWRQEYLKK----RKPHDVAQLLSGVEFGG----TTVGAAYVGGMCSLEYSGGVNEDhskNLESFA 132

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 926492597  170 FTAAHELGHVFNMLHDDSKP---CEElnrhsgASRHMMAPVMSSVDPEEtWSPCSARFITDFLDNGHGHCLLDKP 241
Cdd:pfam01421 133 VTMAHELGHNLGMQHDDFNGgckCPP------GGGCIMNPSAGSSFPRK-FSNCSQEDFEQFLTKQKGACLFNKP 200
ZnMc cd00203
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
 120-229 7.61e-15

Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.


Pssm-ID: 238124 [Multi-domain]  Cd Length: 167  Bit Score: 72.55  E-value: 7.61e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926492597 120 PQHFDTAILFTRQDLcgaaTCNTLGMADVGTVCNPTRSCSIVEDDGL---QSAFTAAHELGHVFNMLHDDSKPCEE---- 192
Cdd:cd00203   49 IDKADIAILVTRQDF----DGGTGGWAYLGRVCDSLRGVGVLQDNQSgtkEGAQTIAHELGHALGFYHDHDRKDRDdypt 124

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 926492597 193 ----LNRHSGASRHMMAPVMSSVDPE--ETWSPCSARFITDFL 229
Cdd:cd00203  125 iddtLNAEDDDYYSVMSYTKGSFSDGqrKDFSQCDIDQINKLY 167
ZnMc_salivary_gland_MPs cd04272
Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary ...
 97-229 3.81e-13

Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods.


Pssm-ID: 239800  Cd Length: 220  Bit Score: 68.92  E-value: 3.81e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926492597  97 NAAQMLRNFCEWQKDlndpdEDSPQHFDTAILFTRQDLC----GAATCNTLGMADVGTVCNPTRsCSIVEDDG--LQSAF 170
Cdd:cd04272   74 DAAETLENFNEYVKK-----KRDYFNPDVVFLVTGLDMStysgGSLQTGTGGYAYVGGACTENR-VAMGEDTPgsYYGVY 147

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 926492597 171 TAAHELGHVFNMLHDDSKPCEELNRHSGASR------HMMAPVMSSVDpEETWSPCSARFITDFL 229
Cdd:cd04272  148 TMTHELAHLLGAPHDGSPPPSWVKGHPGSLDcpwddgYIMSYVVNGER-QYRFSQCSQRQIRNVF 211
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 335-382 1.21e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 56.83  E-value: 1.21e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 926492597   335 GPWAP-SRSCGGGVRFSRRECVKPAPRNGGKYCEGKRTQFRSCNVDACP 382
Cdd:smart00209   5 SEWSPcSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 16-69 1.97e-09

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 55.28  E-value: 1.97e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 926492597   16 VVTIPAGATHILIRQISAAGSgsddvFLALRRPDGTSLLNGNYVLVPSETDVKL 69
Cdd:pfam05986  17 FVTIPAGATHIHIVNRKPSFT-----HLAVKNVQGKYILNGKGSISLNPTYPSL 65
Reprolysin_3 pfam13582
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the ...
 92-185 7.04e-09

Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the characteriztic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.


Pssm-ID: 463926 [Multi-domain]  Cd Length: 122  Bit Score: 53.91  E-value: 7.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926492597   92 PPVTSNAAQMLRNFCEWqkdlNDPDEDSPQhFDTAILFTRQDLCGAAtcntlGMADVGTVCNPTRSCSIVEDD---GLQS 168
Cdd:pfam13582  36 PYTSSDALEILDELQEV----NDTRIGQYG-YDLGHLFTGRDGGGGG-----GIAYVGGVCNSGSKFGVNSGSgpvGDTG 105

                          90
                  ....*....|....*..
gi 926492597  169 AFTAAHELGHVFNMLHD 185
Cdd:pfam13582 106 ADTFAHEIGHNFGLNHT 122
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 494-523 1.23e-07

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 50.27  E-value: 1.23e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 926492597  494 KIYGSFAKAR-YGYNDVVTIPAGATHILIRQ 523
Cdd:pfam05986   1 TVSGSFTEGRaKGYVTFVTIPAGATHIHIVN 31
Reprolysin_5 pfam13688
Metallo-peptidase family M12;
89-206 1.49e-06

Metallo-peptidase family M12;


Pssm-ID: 372673  Cd Length: 191  Bit Score: 48.95  E-value: 1.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926492597   89 TPGPPVTSNAAQMLRNFCEwQKDLNDPDEDspqhfDTAILFTrqdlcgAATCNTLGMADVGTVCNPTRSCSIVEDDG--- 165
Cdd:pfam13688  62 TPPACSTGDSSDRLSEFQD-FSAWRGTQND-----DLAYLFL------MTNCSGGGLAWLGQLCNSGSAGSVSTRVSgnn 129

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 926492597  166 -----LQSAFTAAHELGHVFNMLHD-----DSKPCEELNRHSGAS-RHMMAP 206
Cdd:pfam13688 130 vvvstATEWQVFAHEIGHNFGAVHDcdsstSSQCCPPSNSTCPAGgRYIMNP 181
Reprolysin_2 pfam13574
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the ...
 119-229 2.72e-06

Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the characteriztic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.


Pssm-ID: 372637  Cd Length: 193  Bit Score: 48.01  E-value: 2.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926492597  119 SPQHFDTAILFTRQDLCGAatcnTLGMADVGTVCNPTRSCSIVeDDGLQSAFTA-------------AHELGHVFNMLHD 185
Cdd:pfam13574  67 GEQDYCLAHLVTMGTFSGG----ELGLAYVGQICQKGASSPKT-NTGLSTTTNYgsfnyptqewdvvAHEVGHNFGATHD 141

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 926492597  186 ---DSKPCEELNRHSGAS------RHMMAPvmSSVDPEETWSPCSARFITDFL 229
Cdd:pfam13574 142 cdgSQYASSGCERNAATSvcsangSFIMNP--ASKSNNDLFSPCSISLICDVL 192
ACR smart00608
ADAM Cysteine-Rich Domain;
251-322 4.66e-06

ADAM Cysteine-Rich Domain;


Pssm-ID: 214743  Cd Length: 137  Bit Score: 46.20  E-value: 4.66e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926492597   251 LPGSVYDADRQCQLTFGSESR------------------HC---AGPQPPCAS-------LWCTG--------------- 287
Cdd:smart00608  14 YNGRCPTRDNQCQALFGPGAKvapdscyeelntkgdrfgNCgreNGTYIPCAPedvkcgkLQCTNvselpllgehatviy 93

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 926492597   288 HANGRSMCQTKHFP---------WADGTPCGSGKTCRNGLCVGH 322
Cdd:smart00608  94 SNIGGLVCWSLDYHlgtdpdigmVKDGTKCGPGKVCINGQCVDV 137
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 387-492 5.08e-06

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 45.86  E-value: 5.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926492597  387 LAFREQQCAAYN---YRSDlfKGFPAPMDW---VPRYSGVAekdQCKLTCQSEALGYYHVLEPRVVDGTPCSPE------ 454
Cdd:pfam19236   3 LEFMSQQCARTDgqpLRSS--PGGASFYHWgaaVPHSQGDA---LCRHMCRAIGESFIMKRGDSFLDGTRCMPSgpredg 77

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 926492597  455 STSVCVQGRCIPAGCDRVIGSKKKFDKCMKCGGDGSSC 492
Cdd:pfam19236  78 TLSLCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
ZnMc_ADAM_fungal cd04271
Zinc-dependent metalloprotease, ADAM_fungal subgroup. The adamalysin_like or ADAM (A ...
 100-221 4.45e-04

Zinc-dependent metalloprotease, ADAM_fungal subgroup. The adamalysin_like or ADAM (A Disintegrin And Metalloprotease) family of metalloproteases are integral membrane proteases acting on a variety of extracellular targets. They are involved in shedding soluble peptides or proteins from the cell surface. This subfamily contains fungal ADAMs, whose precise function has yet to be determined.


Pssm-ID: 239799 [Multi-domain]  Cd Length: 228  Bit Score: 42.02  E-value: 4.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926492597 100 QMLRNFCEWQKDLNDPDEDSPQhfdtaiLFTrqdlcgaaTCNT---LGMADVGTVCNPTRScsiveDDGLQSAFTA---- 172
Cdd:cd04271   80 DRLSIFSQWRGQQPDDGNAFWT------LMT--------ACPSgseVGVAWLGQLCRTGAS-----DQGNETVAGTnvvv 140

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 926492597 173 ---------AHELGHVFNMLHD-DSKPCEELNRHSGA------------SRHMMAPvmSSVDPEETWSPCS 221
Cdd:cd04271  141 rtsnewqvfAHEIGHTFGAVHDcTSGTCSDGSVGSQQccplststcdanGQYIMNP--SSSSGITEFSPCT 209
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 334-381 8.11e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 34.74  E-value: 8.11e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 926492597  334 VGPWAP-SRSCGGGVRFSRRECVKPAPR--NGGKYCEGKR--TQFRSCNVDAC 381
Cdd:pfam19030   3 AGPWGEcSVTCGGGVQTRLVQCVQKGGGsiVPDSECSAQKkpPETQSCNLKPC 55
Salp15 pfam12115
Salivary protein of 15kDa inhibits CD4+ T cell activation; This is a family of 15kDa salivary ...
 285-322 9.63e-03

Salivary protein of 15kDa inhibits CD4+ T cell activation; This is a family of 15kDa salivary proteins from Acari Arachnids that is induced on feeding and assists the parasite to remain attached to its arthropod host. By repressing calcium fluxes triggered by TCR engagement, Salp15 inhibits CD4+ T cell activation. Salp15 shows weak similarity to Inhibin A, a member of the TGF-beta superfamily that inhibits the production of cytokines and the proliferation of T cells.


Pssm-ID: 314916  Cd Length: 112  Bit Score: 36.21  E-value: 9.63e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 926492597  285 CTGHANGRSMCQTKHFPwaDGTPCGS-GKTCRNGLCVGH 322
Cdd:pfam12115  72 CGKHNNGGTNITLRQLP--DGTPCGPqGKTCKNGKCVGH 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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