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Conserved domains on  [gi|1002296090|ref|XP_015611504|]
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cocosin 1 [Oryza sativa Japonica Group]

Protein Classification

cupin domain-containing protein( domain architecture ID 1562428)

cupin domain-containing protein, part of a functionally diverse superfamily with the active site generally located at the center of a conserved domain forming a beta-barrel fold

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
cupin_RmlC-like super family cl40423
RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP ...
 211-347 9.02e-34

RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP (deoxythymidine diphosphates)-4-dehydrorhamnose 3,5-epimerase)-like cupins. RmlC is a dTDP-sugar isomerase involved in the synthesis of L-rhamnose, a saccharide required for the virulence of some pathogenic bacteria. Cupins are a functionally diverse superfamily originally discovered based on the highly conserved motif found in germin and germin-like proteins. This conserved motif forms a beta-barrel fold found in all of the cupins, giving rise to the name cupin ('cupa' is the Latin term for small barrel). The active site of members of this superfamily is generally located at the center of a conserved barrel and usually includes a metal ion. The different functional classes in this superfamily include single domain bacterial isomerases and epimerases involved in the modification of cell wall carbohydrates, two domain bicupins such as the desiccation-tolerant seed storage globulins, and multidomain nuclear transcription factors involved in legume root nodulation.


The actual alignment was detected with superfamily member cd02243:

Pssm-ID: 477354  Cd Length: 155  Bit Score: 122.20  E-value: 9.02e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296090 211 KIVTAAHLPVLGQLGFSVGLTPLDAGAaVRGP-WVLrdAAAQAVYVARGSGRVQVAGAGGaSTLLDAEAAAGSLLVVPRY 289
Cdd:cd02243    11 TTLNSFKLPILRFVGLSAERVKLEPNA-MFAPhWNA--NAHQVIYVTRGSGRVQVVGDNG-KRVLDGEVREGQLLVVPQF 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1002296090 290 AVALVGVDAGGMELVSLIKSPRPAMKQFTGKGSVIGGLTPEIVQAALNVSPELVEQLR 347
Cdd:cd02243    87 FAVAKIAGEEGFEWVSFKTSDNPIFSELAGRTSVLRALPPEVLANSYNISPEEAKQLK 144
cupin_RmlC-like super family cl40423
RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP ...
 12-165 9.17e-34

RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP (deoxythymidine diphosphates)-4-dehydrorhamnose 3,5-epimerase)-like cupins. RmlC is a dTDP-sugar isomerase involved in the synthesis of L-rhamnose, a saccharide required for the virulence of some pathogenic bacteria. Cupins are a functionally diverse superfamily originally discovered based on the highly conserved motif found in germin and germin-like proteins. This conserved motif forms a beta-barrel fold found in all of the cupins, giving rise to the name cupin ('cupa' is the Latin term for small barrel). The active site of members of this superfamily is generally located at the center of a conserved barrel and usually includes a metal ion. The different functional classes in this superfamily include single domain bacterial isomerases and epimerases involved in the modification of cell wall carbohydrates, two domain bicupins such as the desiccation-tolerant seed storage globulins, and multidomain nuclear transcription factors involved in legume root nodulation.


The actual alignment was detected with superfamily member cd02242:

Pssm-ID: 477354  Cd Length: 209  Bit Score: 123.85  E-value: 9.17e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296090  12 VENDAGSYLAWSGKNqPALAGEKLGCGLLVLKPLGFALPHYADSGKFGYVLGGSAVVG-VLP-----------------V 73
Cdd:cd02242    13 IESEGGSYEYWDPNN-PQLQCAGVAAGRLTIEPRGLLLPSYSNAPKLAYVLQGRGIVGvVFPgcpetfqssqqsqgqgqR 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296090  74 GLDARERVVRLEAGDVIAMRAGEVTWWYNDADgEDVTIVFMGDTARAAS--PGDISYFVLAGPM---------------G 136
Cdd:cd02242    92 FRDQHQKVRRIRKGDVIAVPAGVVHWWYNDGD-SDLVIVFLGDTSNNANqlDGNFRRFFLAGNPqqeqqgqgqeqsgggN 170

                         170       180
                  ....*....|....*....|....*....
gi 1002296090 137 VLGGLDAGLLATASGLtSPEQAATAFRSQ 165
Cdd:cd02242   171 IFSGFSTEFLAEAFGV-DEETARKLQGSQ 198
 
Name Accession Description Interval E-value
cupin_11S_legumin_C cd02243
11S legumin seed storage globulin, C-terminal cupin domain; This family contains the ...
 211-347 9.02e-34

11S legumin seed storage globulin, C-terminal cupin domain; This family contains the C-terminal domains of 11S legumin seed storage proteins that supply nutrition for seed germination, such as glycinin and legumin, including many common food allergens such as the peanut major allergen Ara h 3, almond allergen Pru du 6, Pecan allergen Car i 4, hazelnut nut allergen Cor a 9, Brazil nut allergen Ber e 2, cashew allergen Ana o 2, pistachio allergen Pis v 2/5, and walnut allergen Jug n/r 4. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). They are synthesized as propeptides in the endoplasmic reticulum and transported to the secretory vesicles as a homotrimer. The propeptides are processed as they are sorted in the secretory vesicles. The homotrimer binds another homotrimer to form a homohexamer with 32-point symmetry formed by a face-to-face stacking of the two trimers. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380370  Cd Length: 155  Bit Score: 122.20  E-value: 9.02e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296090 211 KIVTAAHLPVLGQLGFSVGLTPLDAGAaVRGP-WVLrdAAAQAVYVARGSGRVQVAGAGGaSTLLDAEAAAGSLLVVPRY 289
Cdd:cd02243    11 TTLNSFKLPILRFVGLSAERVKLEPNA-MFAPhWNA--NAHQVIYVTRGSGRVQVVGDNG-KRVLDGEVREGQLLVVPQF 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1002296090 290 AVALVGVDAGGMELVSLIKSPRPAMKQFTGKGSVIGGLTPEIVQAALNVSPELVEQLR 347
Cdd:cd02243    87 FAVAKIAGEEGFEWVSFKTSDNPIFSELAGRTSVLRALPPEVLANSYNISPEEAKQLK 144
cupin_11S_legumin_N cd02242
11S legumin seed storage globulin, N-terminal cupin domain; This family contains the ...
 12-165 9.17e-34

11S legumin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal domains of 11S legumin seed storage proteins that supply nutrition for seed germination, such as glycinin and legumin, including many common food allergens such as the peanut major allergen Ara h 3, almond allergen Pru du 6, Pecan allergen Car i 4, hazelnut nut allergen Cor a 9, Brazil nut allergen Ber e 2, cashew allergen Ana o 2, pistachio allergen Pis v 2/5, and walnut allergen Jug n/r 4. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). They are synthesized as propeptides in the endoplasmic reticulum and transported to the secretory vesicles as a homotrimer. The propeptides are processed as they are sorted in the secretory vesicles. The homotrimer binds another homotrimer to form a homohexamer with 32-point symmetry formed by a face-to-face stacking of the two trimers. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380369  Cd Length: 209  Bit Score: 123.85  E-value: 9.17e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296090  12 VENDAGSYLAWSGKNqPALAGEKLGCGLLVLKPLGFALPHYADSGKFGYVLGGSAVVG-VLP-----------------V 73
Cdd:cd02242    13 IESEGGSYEYWDPNN-PQLQCAGVAAGRLTIEPRGLLLPSYSNAPKLAYVLQGRGIVGvVFPgcpetfqssqqsqgqgqR 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296090  74 GLDARERVVRLEAGDVIAMRAGEVTWWYNDADgEDVTIVFMGDTARAAS--PGDISYFVLAGPM---------------G 136
Cdd:cd02242    92 FRDQHQKVRRIRKGDVIAVPAGVVHWWYNDGD-SDLVIVFLGDTSNNANqlDGNFRRFFLAGNPqqeqqgqgqeqsgggN 170

                         170       180
                  ....*....|....*....|....*....
gi 1002296090 137 VLGGLDAGLLATASGLtSPEQAATAFRSQ 165
Cdd:cd02242   171 IFSGFSTEFLAEAFGV-DEETARKLQGSQ 198
Cupin_1 smart00835
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 195-344 3.61e-22

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 214845 [Multi-domain]  Cd Length: 146  Bit Score: 90.80  E-value: 3.61e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296090  195 ARMPADSSTGGAaagTKIVTAAHLPVLGQLGFSVGLTPLDAGAaVRGPWVlRDAAAQAVYVARGSGRVQVAGAGGaSTLL 274
Cdd:smart00835   2 EPRPDFSNEGGR---LREADPTNFPALNGLGISAARVNLEPGG-MLPPHY-HPRATELLYVVRGEGRVGVVDPNG-NKVY 75

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002296090  275 DAEAAAGSLLVVPR-YAVALVGVDAGGMELVSLiKSPRPAMKQF-TGKGSVIGGLTPEIVQAALNVSPELVE 344
Cdd:smart00835  76 DARLREGDVFVVPQgHPHFQVNSGDENLEFVAF-NTNDPNRRFFlAGRNSVLRGLPPEVLAAAFGVSAEEVR 146
Cupin_1 smart00835
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 7-158 4.98e-15

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 214845 [Multi-domain]  Cd Length: 146  Bit Score: 71.16  E-value: 4.98e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296090    7 AGKPLVENDAGSYLAWSGKNQPALAGEKLGCGLLVLKPLGFALPHY-ADSGKFGYVLGGSAVVGVlpVGLDARERVV-RL 84
Cdd:smart00835   2 EPRPDFSNEGGRLREADPTNFPALNGLGISAARVNLEPGGMLPPHYhPRATELLYVVRGEGRVGV--VDPNGNKVYDaRL 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1002296090   85 EAGDVIAMRAGEVTWWYNDADgEDVTIVFMGDTARAaspgdiSYFVLAGPMGVLGGLDAGLLATASGLtSPEQA 158
Cdd:smart00835  80 REGDVFVVPQGHPHFQVNSGD-ENLEFVAFNTNDPN------RRFFLAGRNSVLRGLPPEVLAAAFGV-SAEEV 145
PLN00212 PLN00212
glutelin; Provisional
 40-347 4.53e-11

glutelin; Provisional


Pssm-ID: 215106 [Multi-domain]  Cd Length: 493  Bit Score: 63.68  E-value: 4.53e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296090  40 LVLKPLGFALPHYADSGKFGYVLGGSAVVGVLPVGL-----------------------DARERVVRLEAGDVIAMRAGE 96
Cdd:PLN00212   85 RVIEPQGLLLPRYSNTPGLVYIIQGRGSMGLTFPGCpatyqqqfqqfltegqsqsqkfrDEHQKIHQFRQGDVVALPAGV 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296090  97 VTWWYNDADGEdVTIVFMGDTARAASPGDISY--FVLAG-----------------PMGVLGGLDAGLLATASGLTSpeQ 157
Cdd:PLN00212  165 AHWFYNDGDAP-VVALYVYDINNNANQLEPRQreFLLAGnnnrqqqvygrsieqhsGQNIFSGFSTELLSEALGINA--Q 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296090 158 AATAFRSQ--PAVLLTRLSRKLQDVRP---REHDRHGIVVNA----------------------------ARM----PAD 200
Cdd:PLN00212  242 VAKRLQSQndQRGEIIRVKNGLQLLQPtltQQQEQAQQQQQRlyqqvqyqqsqqtsgrwngldenfctikVRLnienPSR 321

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296090 201 SSTGGAAAG-TKIVTAAHLPVLGQLGFSVGLTPLDAGAAVRGPWVLRdaAAQAVYVARGSGRVQVAGAGGaSTLLDAEAA 279
Cdd:PLN00212  322 ADTYNPRAGrITRLNSQKFPILNLIQMSATRVNLYQNALLSPFWNVN--AHSVVYITQGRARVQVVSNNG-KTVFNGVLR 398

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1002296090 280 AGSLLVVPRYAVALVGVDAGGMELVSLIKSPRPAMKQFTGKGSVIGGLTPEIVQAALNVSPELVEQLR 347
Cdd:PLN00212  399 PGQLLIIPQHYAVLKKAEREGCQYIAFKTNANAMVSHIAGKNSIFRALPVDVIANAYRISREEARRLK 466
Cupin_1 pfam00190
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 9-156 4.74e-11

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 395138  Cd Length: 151  Bit Score: 60.43  E-value: 4.74e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296090   9 KPLVENDAGSYLAWSGKNQPALAGEKLGCGLLVLKPLGFALPHY-ADSGKFGYVLGGSAVVGVLPVGLDARERVVRLEAG 87
Cdd:pfam00190   7 GPTYNPEGGRVTTVNSKNLPGLNTLGISAARVDLAPGGMNPPHWhPNATEILYVLQGRGRVGFVVPGNGNRVFHKVLREG 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1002296090  88 DVIAMRAGEVTWWYNDADGEDVTIVFMGDTAraasPGDISyfVLAGPMGVLGGLDAGLLATASGLTSPE 156
Cdd:pfam00190  87 DVFVVPQGLPHFQYNIGDEPAVAFVAFDTNN----PGNQS--ILAGGFSSLPALPPEVLAKAFQLAGEE 149
Cupin_1 pfam00190
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 198-344 5.08e-11

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 395138  Cd Length: 151  Bit Score: 60.04  E-value: 5.08e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296090 198 PADSSTGGAaagTKIVTAAHLPVLGQLGFSVGLTPLDAGAaVRGP-WVLRdaAAQAVYVARGSGRVQVAGAGGASTLLDA 276
Cdd:pfam00190   8 PTYNPEGGR---VTTVNSKNLPGLNTLGISAARVDLAPGG-MNPPhWHPN--ATEILYVLQGRGRVGFVVPGNGNRVFHK 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296090 277 EAAAGSLLVVPR-YAVALVGV-DAGGMELVSLIKSPRPAMKQFTGKGSVIGGLTPEIVQAALNVSPELVE 344
Cdd:pfam00190  82 VLREGDVFVVPQgLPHFQYNIgDEPAVAFVAFDTNNPGNQSILAGGFSSLPALPPEVLAKAFQLAGEEVK 151
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
50-114 4.67e-05

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 41.76  E-value: 4.67e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1002296090  50 PHYADSGKFGYVLGGSAVVGVlpvgldaRERVVRLEAGDVIAMRAGEVTWWYNDADGEDVTIVFM 114
Cdd:COG1917    38 WHSHPGEELIYVLEGEGEVEV-------GGEEYELKPGDVVFIPPGVPHAFRNLGDEPAVLLVVF 95
 
Name Accession Description Interval E-value
cupin_11S_legumin_C cd02243
11S legumin seed storage globulin, C-terminal cupin domain; This family contains the ...
 211-347 9.02e-34

11S legumin seed storage globulin, C-terminal cupin domain; This family contains the C-terminal domains of 11S legumin seed storage proteins that supply nutrition for seed germination, such as glycinin and legumin, including many common food allergens such as the peanut major allergen Ara h 3, almond allergen Pru du 6, Pecan allergen Car i 4, hazelnut nut allergen Cor a 9, Brazil nut allergen Ber e 2, cashew allergen Ana o 2, pistachio allergen Pis v 2/5, and walnut allergen Jug n/r 4. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). They are synthesized as propeptides in the endoplasmic reticulum and transported to the secretory vesicles as a homotrimer. The propeptides are processed as they are sorted in the secretory vesicles. The homotrimer binds another homotrimer to form a homohexamer with 32-point symmetry formed by a face-to-face stacking of the two trimers. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380370  Cd Length: 155  Bit Score: 122.20  E-value: 9.02e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296090 211 KIVTAAHLPVLGQLGFSVGLTPLDAGAaVRGP-WVLrdAAAQAVYVARGSGRVQVAGAGGaSTLLDAEAAAGSLLVVPRY 289
Cdd:cd02243    11 TTLNSFKLPILRFVGLSAERVKLEPNA-MFAPhWNA--NAHQVIYVTRGSGRVQVVGDNG-KRVLDGEVREGQLLVVPQF 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1002296090 290 AVALVGVDAGGMELVSLIKSPRPAMKQFTGKGSVIGGLTPEIVQAALNVSPELVEQLR 347
Cdd:cd02243    87 FAVAKIAGEEGFEWVSFKTSDNPIFSELAGRTSVLRALPPEVLANSYNISPEEAKQLK 144
cupin_11S_legumin_N cd02242
11S legumin seed storage globulin, N-terminal cupin domain; This family contains the ...
 12-165 9.17e-34

11S legumin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal domains of 11S legumin seed storage proteins that supply nutrition for seed germination, such as glycinin and legumin, including many common food allergens such as the peanut major allergen Ara h 3, almond allergen Pru du 6, Pecan allergen Car i 4, hazelnut nut allergen Cor a 9, Brazil nut allergen Ber e 2, cashew allergen Ana o 2, pistachio allergen Pis v 2/5, and walnut allergen Jug n/r 4. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). They are synthesized as propeptides in the endoplasmic reticulum and transported to the secretory vesicles as a homotrimer. The propeptides are processed as they are sorted in the secretory vesicles. The homotrimer binds another homotrimer to form a homohexamer with 32-point symmetry formed by a face-to-face stacking of the two trimers. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380369  Cd Length: 209  Bit Score: 123.85  E-value: 9.17e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296090  12 VENDAGSYLAWSGKNqPALAGEKLGCGLLVLKPLGFALPHYADSGKFGYVLGGSAVVG-VLP-----------------V 73
Cdd:cd02242    13 IESEGGSYEYWDPNN-PQLQCAGVAAGRLTIEPRGLLLPSYSNAPKLAYVLQGRGIVGvVFPgcpetfqssqqsqgqgqR 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296090  74 GLDARERVVRLEAGDVIAMRAGEVTWWYNDADgEDVTIVFMGDTARAAS--PGDISYFVLAGPM---------------G 136
Cdd:cd02242    92 FRDQHQKVRRIRKGDVIAVPAGVVHWWYNDGD-SDLVIVFLGDTSNNANqlDGNFRRFFLAGNPqqeqqgqgqeqsgggN 170

                         170       180
                  ....*....|....*....|....*....
gi 1002296090 137 VLGGLDAGLLATASGLtSPEQAATAFRSQ 165
Cdd:cd02242   171 IFSGFSTEFLAEAFGV-DEETARKLQGSQ 198
Cupin_1 smart00835
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 195-344 3.61e-22

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 214845 [Multi-domain]  Cd Length: 146  Bit Score: 90.80  E-value: 3.61e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296090  195 ARMPADSSTGGAaagTKIVTAAHLPVLGQLGFSVGLTPLDAGAaVRGPWVlRDAAAQAVYVARGSGRVQVAGAGGaSTLL 274
Cdd:smart00835   2 EPRPDFSNEGGR---LREADPTNFPALNGLGISAARVNLEPGG-MLPPHY-HPRATELLYVVRGEGRVGVVDPNG-NKVY 75

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002296090  275 DAEAAAGSLLVVPR-YAVALVGVDAGGMELVSLiKSPRPAMKQF-TGKGSVIGGLTPEIVQAALNVSPELVE 344
Cdd:smart00835  76 DARLREGDVFVVPQgHPHFQVNSGDENLEFVAF-NTNDPNRRFFlAGRNSVLRGLPPEVLAAAFGVSAEEVR 146
Cupin_1 smart00835
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 7-158 4.98e-15

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 214845 [Multi-domain]  Cd Length: 146  Bit Score: 71.16  E-value: 4.98e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296090    7 AGKPLVENDAGSYLAWSGKNQPALAGEKLGCGLLVLKPLGFALPHY-ADSGKFGYVLGGSAVVGVlpVGLDARERVV-RL 84
Cdd:smart00835   2 EPRPDFSNEGGRLREADPTNFPALNGLGISAARVNLEPGGMLPPHYhPRATELLYVVRGEGRVGV--VDPNGNKVYDaRL 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1002296090   85 EAGDVIAMRAGEVTWWYNDADgEDVTIVFMGDTARAaspgdiSYFVLAGPMGVLGGLDAGLLATASGLtSPEQA 158
Cdd:smart00835  80 REGDVFVVPQGHPHFQVNSGD-ENLEFVAFNTNDPN------RRFFLAGRNSVLRGLPPEVLAAAFGV-SAEEV 145
PLN00212 PLN00212
glutelin; Provisional
 40-347 4.53e-11

glutelin; Provisional


Pssm-ID: 215106 [Multi-domain]  Cd Length: 493  Bit Score: 63.68  E-value: 4.53e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296090  40 LVLKPLGFALPHYADSGKFGYVLGGSAVVGVLPVGL-----------------------DARERVVRLEAGDVIAMRAGE 96
Cdd:PLN00212   85 RVIEPQGLLLPRYSNTPGLVYIIQGRGSMGLTFPGCpatyqqqfqqfltegqsqsqkfrDEHQKIHQFRQGDVVALPAGV 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296090  97 VTWWYNDADGEdVTIVFMGDTARAASPGDISY--FVLAG-----------------PMGVLGGLDAGLLATASGLTSpeQ 157
Cdd:PLN00212  165 AHWFYNDGDAP-VVALYVYDINNNANQLEPRQreFLLAGnnnrqqqvygrsieqhsGQNIFSGFSTELLSEALGINA--Q 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296090 158 AATAFRSQ--PAVLLTRLSRKLQDVRP---REHDRHGIVVNA----------------------------ARM----PAD 200
Cdd:PLN00212  242 VAKRLQSQndQRGEIIRVKNGLQLLQPtltQQQEQAQQQQQRlyqqvqyqqsqqtsgrwngldenfctikVRLnienPSR 321

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296090 201 SSTGGAAAG-TKIVTAAHLPVLGQLGFSVGLTPLDAGAAVRGPWVLRdaAAQAVYVARGSGRVQVAGAGGaSTLLDAEAA 279
Cdd:PLN00212  322 ADTYNPRAGrITRLNSQKFPILNLIQMSATRVNLYQNALLSPFWNVN--AHSVVYITQGRARVQVVSNNG-KTVFNGVLR 398

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1002296090 280 AGSLLVVPRYAVALVGVDAGGMELVSLIKSPRPAMKQFTGKGSVIGGLTPEIVQAALNVSPELVEQLR 347
Cdd:PLN00212  399 PGQLLIIPQHYAVLKKAEREGCQYIAFKTNANAMVSHIAGKNSIFRALPVDVIANAYRISREEARRLK 466
Cupin_1 pfam00190
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 9-156 4.74e-11

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 395138  Cd Length: 151  Bit Score: 60.43  E-value: 4.74e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296090   9 KPLVENDAGSYLAWSGKNQPALAGEKLGCGLLVLKPLGFALPHY-ADSGKFGYVLGGSAVVGVLPVGLDARERVVRLEAG 87
Cdd:pfam00190   7 GPTYNPEGGRVTTVNSKNLPGLNTLGISAARVDLAPGGMNPPHWhPNATEILYVLQGRGRVGFVVPGNGNRVFHKVLREG 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1002296090  88 DVIAMRAGEVTWWYNDADGEDVTIVFMGDTAraasPGDISyfVLAGPMGVLGGLDAGLLATASGLTSPE 156
Cdd:pfam00190  87 DVFVVPQGLPHFQYNIGDEPAVAFVAFDTNN----PGNQS--ILAGGFSSLPALPPEVLAKAFQLAGEE 149
Cupin_1 pfam00190
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 198-344 5.08e-11

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 395138  Cd Length: 151  Bit Score: 60.04  E-value: 5.08e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296090 198 PADSSTGGAaagTKIVTAAHLPVLGQLGFSVGLTPLDAGAaVRGP-WVLRdaAAQAVYVARGSGRVQVAGAGGASTLLDA 276
Cdd:pfam00190   8 PTYNPEGGR---VTTVNSKNLPGLNTLGISAARVDLAPGG-MNPPhWHPN--ATEILYVLQGRGRVGFVVPGNGNRVFHK 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296090 277 EAAAGSLLVVPR-YAVALVGV-DAGGMELVSLIKSPRPAMKQFTGKGSVIGGLTPEIVQAALNVSPELVE 344
Cdd:pfam00190  82 VLREGDVFVVPQgLPHFQYNIgDEPAVAFVAFDTNNPGNQSILAGGFSSLPALPPEVLAKAFQLAGEEVK 151
cupin_7S_vicilin-like_N cd02244
7S vicilin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal ...
 38-149 2.94e-09

7S vicilin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal domains of plant 7S seed storage proteins such as vicilin, and includes beta-conglycinin, phaseolin, canavalin, conglutin-beta, a chromatin protein in Pisum sativum called P54, and a sucrose binding protein in soybean called SBP. These 7S globulins also include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2, and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The vicilin peptides formed by trypsin or chymotrypsin digestion exhibit antihypertensive effects. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380371  Cd Length: 178  Bit Score: 55.59  E-value: 2.94e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296090  38 GLLVLKPLGFALPHYADSGKFGYVLGGSAVVGVlpVGLDARERvVRLEAGDVIAMRAGEVTWWYNDADGEDVTIVFMGDT 117
Cdd:cd02244    31 AFITMEPNTLFLPHHLDADMVFYVHTGRGTITW--VDEDKRES-YNLERGDVYRIPAGSTFYLVNTDENEKLRIIALFDP 107

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1002296090 118 ARAASPGDISYFVLAG---PMGVLGGLDAGLLATA 149
Cdd:cd02244   108 VNSLTPGPFQSFFGAGgqnPESLLSGFSKEILEAA 142
cupin_OxDC-like cd20306
Oxalate decarboxylase (OxDC)-like cupin domain; This subfamily contains bacterial and ...
 9-147 5.30e-06

Oxalate decarboxylase (OxDC)-like cupin domain; This subfamily contains bacterial and eukaryotic cupin domains of proteins homologous to oxalate decarboxylase (OxDC; EC 4.1.1.2) such as MSMEG_2254, a putative OxDC from Mycobacterium smegmatis. OxDC is a manganese-dependent bicupin that catalyzes the conversion of oxalate to formate and carbon dioxide, utilizing dioxygen as a cofactor. It is evolutionarily related to oxalate oxidase (OxOx or germin; EC 1.2.3.4) which, in contrast, converts oxalate and dioxygen to carbon dioxide and hydrogen peroxide. OxDC is classified as a bicupin because it contains two cupin folds with each domain containing one manganese binding site, with four manganese binding residues (three histidines and one glutamate) conserved as well as a number of hydrophobic residues.


Pssm-ID: 380440 [Multi-domain]  Cd Length: 151  Bit Score: 45.66  E-value: 5.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296090   9 KPLVENDAGSYLAWSGKNQPALagEKLGCGLLVLKPLGFALPHY-ADSGKFGYVLGGSAVVGVLpvGLDARERVVRLEAG 87
Cdd:cd20306    10 NPFFESEGGSIRQATADQLPVL--KGLSIYRLRLSPGGIREPHWhPNANELGYVISGEARVSIL--DPTGSLDTFTVKPG 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1002296090  88 DVIAMRAGevtWWYN-DADGED---VTIVFmgdtaRAASPGDISY--FVLAGPMGVLG---GLDAGLLA 147
Cdd:cd20306    86 QVVFIPQG---WLHWiENVGDEeahLLIFF-----NHETPEDIGLsdSLRATPPEVLGntyGVDAFFAA 146
cupin_7S_vicilin-like_C cd02245
7S vicilin seed storage globulin, C-terminal cupin domain; This family contains C-terminal ...
 213-346 6.32e-06

7S vicilin seed storage globulin, C-terminal cupin domain; This family contains C-terminal domain of plant 7S seed storage protein such as vicilin and includes beta-conglycinin, phaseolin, canavalin, conglutin-beta, a chromatin protein in Pisum sativum called P54, and a sucrose binding protein in soybean called SBP. These 7S globulins also include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2 and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The vicilin peptides formed by trypsin or chymotrypsin digestion exhibit antihypertensive effects. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380372  Cd Length: 166  Bit Score: 45.97  E-value: 6.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296090 213 VTAAHLPVLGQLGFSVGLTPLDAGAAVrGP-WVLRdaAAQAVYVARGSGRVQVAGAGGASTL-------------LDAEA 278
Cdd:cd02245    13 ADPEDYKQLKDLDVGVSFVNITQGSMM-APhYNSR--ATEIAVVVEGEGYVEMVCPHLSSQSqqgeeegsgeyqkVRARL 89

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296090 279 AAGSLLVVPR-YAVALVGVDAGGMELVSLIKSPRPAMKQF-TGKGSVIGGLTPEIVQAALNVSPELVEQL 346
Cdd:cd02245    90 SEGDVFVVPAgHPVAQVASSNENLEFVGFGINAQNNERQFlAGKNNVLRQLDREAKELAFNVPAEEVEEV 159
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
50-114 4.67e-05

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 41.76  E-value: 4.67e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1002296090  50 PHYADSGKFGYVLGGSAVVGVlpvgldaRERVVRLEAGDVIAMRAGEVTWWYNDADGEDVTIVFM 114
Cdd:COG1917    38 WHSHPGEELIYVLEGEGEVEV-------GGEEYELKPGDVVFIPPGVPHAFRNLGDEPAVLLVVF 95
cupin_RmlC-like cd02208
RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP ...
 38-113 1.90e-03

RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP (deoxythymidine diphosphates)-4-dehydrorhamnose 3,5-epimerase)-like cupins. RmlC is a dTDP-sugar isomerase involved in the synthesis of L-rhamnose, a saccharide required for the virulence of some pathogenic bacteria. Cupins are a functionally diverse superfamily originally discovered based on the highly conserved motif found in germin and germin-like proteins. This conserved motif forms a beta-barrel fold found in all of the cupins, giving rise to the name cupin ('cupa' is the Latin term for small barrel). The active site of members of this superfamily is generally located at the center of a conserved barrel and usually includes a metal ion. The different functional classes in this superfamily include single domain bacterial isomerases and epimerases involved in the modification of cell wall carbohydrates, two domain bicupins such as the desiccation-tolerant seed storage globulins, and multidomain nuclear transcription factors involved in legume root nodulation.


Pssm-ID: 380338 [Multi-domain]  Cd Length: 73  Bit Score: 36.69  E-value: 1.90e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002296090  38 GLLVLKPLGFALPHYADSG-KFGYVLGGSAVVGVlpvglDARERVVrLEAGDVIAMRAGEVTWWYNDADGEDVTIVF 113
Cdd:cd02208     2 SVVTLPPGTSSPPHWHPEQdEIFYVLSGEGELTL-----DDGETVE-LKAGDIVLIPPGVPHSFVNTSDEPAVFLVV 72
cupin_OxDC-like cd20306
Oxalate decarboxylase (OxDC)-like cupin domain; This subfamily contains bacterial and ...
 212-341 4.70e-03

Oxalate decarboxylase (OxDC)-like cupin domain; This subfamily contains bacterial and eukaryotic cupin domains of proteins homologous to oxalate decarboxylase (OxDC; EC 4.1.1.2) such as MSMEG_2254, a putative OxDC from Mycobacterium smegmatis. OxDC is a manganese-dependent bicupin that catalyzes the conversion of oxalate to formate and carbon dioxide, utilizing dioxygen as a cofactor. It is evolutionarily related to oxalate oxidase (OxOx or germin; EC 1.2.3.4) which, in contrast, converts oxalate and dioxygen to carbon dioxide and hydrogen peroxide. OxDC is classified as a bicupin because it contains two cupin folds with each domain containing one manganese binding site, with four manganese binding residues (three histidines and one glutamate) conserved as well as a number of hydrophobic residues.


Pssm-ID: 380440 [Multi-domain]  Cd Length: 151  Bit Score: 37.19  E-value: 4.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296090 212 IVTAAHLPVLGQLG-FSVGLTPldagAAVRGP-WvlRDAAAQAVYVARGSGRVQVAGAGGasTLLDAEAAAGSLLVVPR- 288
Cdd:cd20306    22 QATADQLPVLKGLSiYRLRLSP----GGIREPhW--HPNANELGYVISGEARVSILDPTG--SLDTFTVKPGQVVFIPQg 93

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1002296090 289 YAVALVGVDAGGMELVSLIKSPRPamkQFTGKGSVIGGLTPEIVQAALNVSPE 341
Cdd:cd20306    94 WLHWIENVGDEEAHLLIFFNHETP---EDIGLSDSLRATPPEVLGNTYGVDAF 143
Cupin_2 pfam07883
Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ( ...
 38-107 9.29e-03

Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).


Pssm-ID: 462300 [Multi-domain]  Cd Length: 71  Bit Score: 34.54  E-value: 9.29e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1002296090  38 GLLVLKPLGFALPHY-ADSGKFGYVLGGSAVVGVlpvgldaRERVVRLEAGDVIAMRAGEVTWWYNDADGE 107
Cdd:pfam07883   1 GLVTLPPGESSPPHRhPGEDEFFYVLEGEGELTV-------DGEEVVLKAGDSVYFPAGVPHRFRNTGDEP 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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