|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
3-1086 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 2351.25 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 3 SNPDGGRSFARRDILLKIQSDAQKWWEESKVFEAEPGNKPPGPGEKFFGNFPYPYMNGLLHLGHAFSLSKLEFGAAYQRL 82
Cdd:PLN02959 1 MMAEGGKSTARRDRLLEIEVAVQKWWEEEKVFEAEAGDEPPKPGEKFFGNFPYPYMNGLLHLGHAFSLSKLEFAAAYHRL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 83 RGSNVLLPFAFHCTGMPIKASADKLSREAQQYGYPPAFPEVEDDSSAEVADSSQADNAASVVPDKFKSKKSKAASKVGMQ 162
Cdd:PLN02959 81 RGANVLLPFAFHCTGMPIKASADKLAREIQQYGNPPVFPEEDEDEAAAVAAAKAEAEAAAAPPDKFKGKKSKAVAKSGTQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 163 KFQWEIMRGFGLSDEEIAKFQDPYHWLTYFPPLAKEDLKAFGLGCDWRRSFITTDMNPFYDAFVRWQMRKLKKMGKVVKD 242
Cdd:PLN02959 161 KYQWEIMRSFGLPDSEIAKFQDPYHWLSYFPPLAKEDLKAFGLGCDWRRSFITTDVNPYYDAFVRWQFRKLKKKGKIVKD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 243 MRYTIYSPLDGQPCADHDRASGEGVQPQEYVLIKMEVVPPFPPKLKTMEGRNVYLAAATLRPETMYGQTNCWVLPDGKYG 322
Cdd:PLN02959 241 KRYTIYSPLDGQPCADHDRASGEGVGPQEYVLIKMEVLPPFPGKLKALEGKKVFLAAATLRPETMYGQTNCWVLPDGKYG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 323 AFEINDTDVFIVTSRAALNLAYQNLSRVPEKPTCLMELSGCDLIGLPLKSPLAFNEIIYALPMLTILTDKGTGIVTSVPS 402
Cdd:PLN02959 321 AYEINDTEVFILTARAALNLAYQNFSKVPGKPTCLVELTGYDLIGLPLKSPLAFNEVIYALPMLTILTDKGTGVVTSVPS 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 403 DSPDDFMALQDLVAKPALRQKYGVKDEWVLPFKVVPIINIPEFGDKSAEKVCLDLKIKSQNDKEKLAEAKRMTYLKGFTD 482
Cdd:PLN02959 401 DSPDDYMALSDLKAKPALRAKYGVKDEWVLPFEVVPIINIPEFGDKSAEKVCEDLKIKSQNDKEKLAEAKRLTYLKGFTD 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 483 GTMIVGEFNGRKVQEAKPLIKNKLLEEGTAVLYSEPEKKVMSRSGDECVVALTDQWYITYGETEWKQKAVQCLEKMNTFS 562
Cdd:PLN02959 481 GTMLVGEYAGRKVQEAKPLIKKKLIEAGQAILYSEPEKKVMSRSGDECVVALTDQWYLTYGEEEWKKKAEKCLSKMNLYS 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 563 AETRNGFEHTLGWLNQWACSRSFGLGTRIPWDEQFLVESLSDSTLYMAYYTIAHLLQNGNMYGKEISSIRPEQMTDEVWD 642
Cdd:PLN02959 561 DETRHGFEHTLGWLNQWACSRSFGLGTRIPWDEQFLIESLSDSTIYMAYYTVAHLLQGGDMYGKDKSSIKPEQMTDEVWD 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 643 YVFCDGPAP-NSDIPPALLSKMKLEFEYWYPFDIRVSGKDLIQNHLTFSIYNHTALLPEHHWPRGFRCNGHLMLNSEKMS 721
Cdd:PLN02959 641 FVFCGGPLPkSSDIPAELLEKMKQEFEYWYPFDLRVSGKDLIQNHLTFAIYNHTAIWAEEHWPRGFRCNGHLMLNSEKMS 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 722 KSTGNFRTLRQAIEEFSSDATRFALADAGDGMDDANFVFETANAAILRLTKEIAWMEEVIAAESSLRAGPPSTYADHVFA 801
Cdd:PLN02959 721 KSTGNFLTLRQAIEEFSADATRFALADAGDGVDDANFVFETANAAILRLTKEIAWMEEVLAAESSLRTGPPSTYADRVFE 800
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 802 NEINIAVIETEKSYNAFMFRDALKLGFYDLQLARDEYRLSCGAAGMNRELLWRFMEVQTRLITPICPHYAEHVWRNILRK 881
Cdd:PLN02959 801 NEINIAIAETEKNYEAMMFREALKSGFYDLQAARDEYRLSCGSGGMNRDLVWRFMDVQTRLITPICPHYAEHVWREILKK 880
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 882 EGFAIKAGWPIAGTPDPTLRIANKYLQDSIVKFRKLLQKQESGSKKPKKGtAPPPSEQNKLTVGLVYVNENYYGWKEQCL 961
Cdd:PLN02959 881 EGFAVTAGWPVAGEPDLTLKRANKYLQDSIVSFRKLLQKQLAGSKKAKKG-GAPVTLPEKKLAGLIYVAEKYDGWKEECL 959
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 962 RVLQSKFDSQARLFAPDEEINEALKNCSIGQETNFKQVQKLCMPFIKSKKDEARSVGPHALNLKLPFGEMSVLEENLELI 1041
Cdd:PLN02959 960 RILQSKFDSQSRTFAPDAEILEALKESSVGQEANFKQVQKLCMPFVKFKKDEAIAVGPQALDLKLPFDEIEVLQENLELI 1039
|
1050 1060 1070 1080
....*....|....*....|....*....|....*....|....*
gi 1002296767 1042 KRQVGLEHAEVLSASDEAARAKAGVHASMLDKTPPSPGEPVAIFM 1086
Cdd:PLN02959 1040 KRQLGLEEVEILSASDPDAVAKAGAHASLLKQNPPSPGNPVAIFV 1084
|
|
| leuS_arch |
TIGR00395 |
leucyl-tRNA synthetase, archaeal and cytosolic family; The leucyl-tRNA synthetases belong to ... |
20-1048 |
0e+00 |
|
leucyl-tRNA synthetase, archaeal and cytosolic family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both archaeal and cytosolic eukaryotic leucyl-tRNA synthetases; the eubacterial and mitochondrial forms differ so substantially that some other tRNA ligases score higher by this model than does any eubacterial LeuS. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273056 [Multi-domain] Cd Length: 938 Bit Score: 824.46 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 20 IQSDAQKWWEESKVFEAEPGNKppgpgEKFFGNFPYPYMNGLLHLGHAFSLSKLEFGAAYQRLRGSNVLLPFAFHCTGMP 99
Cdd:TIGR00395 3 IEKKWQKRWEEAHIFEADPDDR-----EKFFLTMAYPYLNGVMHAGHCRTFTIPEVSARFERMKGKNVLFPLGFHVTGTP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 100 IKASADKLSREAQQYGYppAFPEVEDdssaevadssqadnaasvVPDkfkskkskaaskvgmqkfqweimrgfglsdEEI 179
Cdd:TIGR00395 78 ILGLAELIKRRDELTIK--NYTEVHA------------------IPR------------------------------EEL 107
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 180 AKFQDPYHWLTYFPPLAKEDLKAFGLGCDWRRSFITTDmnPFYDAFVRWQMRKLKKMGKVVKDMRYTIYSPLDGQPCADH 259
Cdd:TIGR00395 108 LKFTDPEYIVEYFSREAESACKSMGYSIDWRRSFKTTD--PYYDRFIEWQMNKLKELGLIVKGEHPVRYCPKDGNPVEDH 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 260 DRASGEGVQPQEYVLIKMEvvppfppklktMEGRNVYLAAATLRPETMYGQTNCWVLPDGKYGAFEINDTDvFIVTSRAA 339
Cdd:TIGR00395 186 DLLSGEGVTIVEYILIKFE-----------LEDGAFYFVAATLRPETVYGVTNCWVNPTITYVIAEVGGEK-WITSKEAF 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 340 LNLAYQNLSRVPekptcLMELSGCDLIGLPLKSPLAFNEIiYALPMLTILTDKGTGIVTSVPSDSPDDFMALQDLVAKPA 419
Cdd:TIGR00395 254 ENLSYQKLKYKP-----IEEVPGKQFIGKKVHNPVVGPEV-PILPAEFVDTTKGTGVVMSVPAHAPDDYIALEDLLHDPE 327
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 420 LrqkYGVKDEWVlPFKVVPIINIPEFGDKSAEKVCLDLKIKSQNDKEKLAEAKRMTYLKGFTDGTMIVGEFN--GRKVQE 497
Cdd:TIGR00395 328 Y---LGIKPVVI-DIEPVPLIHTDGYGDLPAKEIVEEKGIKSQKDKNLLEEATKILYKEEYHTGVMIYNIPPykGMKVSE 403
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 498 AKPLIKNKLLEEGTAVLYSEP-EKKVMSRSGDECVV-ALTDQWYITYGETEWKQKAVQCLEKMNTFSAETRNGFEHTLGW 575
Cdd:TIGR00395 404 AKEKVKADLIDAGLADVMYEFsESPVICRCGTDCIVkVVEDQWFVKYSDESWKELAHECLEGMRIIPEEVKNAFEGKIDW 483
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 576 LNQWACSRSFGLGTRIPWDEQFLVESLSDSTLYMAYYTIAHLLQNGNmygkeissIRPEQMTDEVWDYVFC-DGPAPNSD 654
Cdd:TIGR00395 484 LKDWACCRRYGLGTRLPWDEKWLIESLSDSTIYMAYYTIAHYLNKDY--------YGNEQMTDEFFDYIFLgKGDVKNTN 555
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 655 IPPALLSKMKLEFEYWYPFDIRVSGKDLIQNHLTFSIYNHTALLPEHHWPRGFRCNGHLMLNSEKMSKSTGNFRTLRQAI 734
Cdd:TIGR00395 556 IPLPAIQKLRREFEYWYPLDWRISGKDLIPNHLTFYIFHHVAIFPEKFWPRGIVVNGYVMLEGKKMSKSKGNVLTLEQAV 635
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 735 EEFSSDATRFALADAGDGMDDANFVFETANAAILRLTKEIAWMEEvIAAESSLRAGPPSTYADHVFANEINIAVIETEKS 814
Cdd:TIGR00395 636 EKFGADVARLYIADAAETVQDADWKESEVEGTILRLERLYEFAEE-ITKESNLETGEETSFIDRWLESRMNAAIKETYEA 714
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 815 YNAFMFRDALKLGFYDLQLARDEYRLSCGaaGMNRELLWRFMEVQTRLITPICPHYAEHVWRnILRKEGFAIKAGWPIAG 894
Cdd:TIGR00395 715 MENFQTRKAVKYALFDLQADVDWYRRRGG--VNHKDVLARYLETWIKLLAPFAPHFAEEMWE-EVGNEGFVSLAKFPEAS 791
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 895 TP--DPTLRIANKYLQDSIvkfRKLLQKQESGSKKPKKGTapppseqnkltvglVYVNENyygWKEQCLRVLQSKFdsqa 972
Cdd:TIGR00395 792 EPavDKEVEAAEEYLRNLV---RDIQEIAKIDASKPKRVY--------------LYTSED---WKSQCLKIVAELF---- 847
|
970 980 990 1000 1010 1020 1030
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1002296767 973 rlfapDEEINEALKNCSIGQEtnfkqVQKLCMPFIKSKKDEARSVGPHALNLklpFGEMSVLEENLELIKRQVGLE 1048
Cdd:TIGR00395 848 -----GEDTGEDMKKVMEEPE-----ERKRGKEVISLVKQIIKDEKKEDELQ---ISEIEVLKAAARFIKKEVGAL 910
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
62-1086 |
0e+00 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 717.03 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 62 LHLGHAFSLSKLEFGAAYQRLRGSNVLLPFAFHCTGMPIKASADKLSReaqqygyppafpeveddssaevadssqadnaa 141
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPILGIAERIAR-------------------------------- 48
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 142 svvpdkfkskkskaaskvGMQKFQWEIMRGFGLSDEEIAKFQDPYHWLTYFPPLAKEDLKAFGLGCDWRRSFITTDmnPF 221
Cdd:PRK12300 49 ------------------GDPETIELYKSLYGIPEEELEKFKDPEYIVEYFSEEAKEDMKRIGYSIDWRREFTTTD--PE 108
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 222 YDAFVRWQMRKLKKMGKVVKDMRYTIYSPLDGQPCADHDRASGEGVQPQEYVLIKMEvvppfppklktmEGRNVYLAAAT 301
Cdd:PRK12300 109 YSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPVGDHDLLDGEEPEIVEYTLIKFE------------ESEDLILPAAT 176
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 302 LRPETMYGQTNCWVLPDGKYGAFEINDtDVFIVTSRAALNLAYQNLSRVPEKptclmELSGCDLIGLPLKSPLAFNEIIy 381
Cdd:PRK12300 177 LRPETIFGVTNLWVNPDATYVKAEVDG-EKWIVSKEAAEKLSFQDRDVEIIE-----EIKGSELIGKKVKNPVTGKEVP- 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 382 ALPMLTILTDKGTGIVTSVPSDSPDDFMALQDLvakpalrqkyGVKDEWVLPFKVVPIINIPEFGDKSAEKVCLDLKIKS 461
Cdd:PRK12300 250 ILPADFVDPDNGTGVVMSVPAHAPYDYVALRDL----------KKNKELLDVIEPIPLIEVEGYGEFPAKEVVEKLGIKS 319
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 462 QNDkEKLAEAKRMTYLKGFTDGTMI--VGEFNGRKVQEAKPLIKNKLLEEGTA-VLYSEPEKKVMSRSGDECVVA-LTDQ 537
Cdd:PRK12300 320 QED-PELEEATKEVYRAEFHKGVLKenTGEYAGKPVREAREKITKDLIEKGIAdIMYEFSNRPVYCRCGTECVVKvVKDQ 398
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 538 WYITYGETEWKQKAVQCLEKMNTFSAETRNGFEHTLGWLNQWACSRSFGLGTRIPWDEQFLVESLSDSTLYMAYYTIAHL 617
Cdd:PRK12300 399 WFIDYSDPEWKELAHKALDNMEIIPEEYRKEFENTIDWLKDRACARRRGLGTRLPWDEEWIIESLSDSTIYMAYYTIAHK 478
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 618 LQNGNmygkeissIRPEQMTDEVWDYVF-----CDGPAPNSDIPPALLSKMKLEFEYWYPFDIRVSGKDLIQNHLTFSIY 692
Cdd:PRK12300 479 IREYG--------IKPEQLTPEFFDYVFlgkgdPEEVSKKTGIPKEILEEMREEFLYWYPVDWRHSGKDLIPNHLTFFIF 550
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 693 NHTALLPEHHWPRGFRCNGHLMLNSEKMSKSTGNFRTLRQAIEEFSSDATRFALADAGDGMDDANFVFETANAAILRLTK 772
Cdd:PRK12300 551 NHVAIFPEEKWPRGIVVNGFVLLEGKKMSKSKGNVIPLRKAIEEYGADVVRLYLTSSAELLQDADWREKEVESVRRQLER 630
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 773 EIAWMEEVIAAESslraGPPSTYADHVFANEINIAVIETEKSYNAFMFRDALKLGFYDLQLARDEYRLSCGAAgmNRELL 852
Cdd:PRK12300 631 FYELAKELIEIGG----EEELRFIDKWLLSRLNRIIKETTEAMESFQTRDAVQEAFYELLNDLRWYLRRVGEA--NNKVL 704
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 853 WRFMEVQTRLITPICPHYAEHVWRnILRKEGFAIKAGWPIAG--TPDPTLRIANKYLQD------SIVKFRKllqkqesg 924
Cdd:PRK12300 705 REVLEIWIRLLAPFTPHLAEELWH-KLGGEGFVSLEKWPEPDesKIDEEAELAEEYVKRliedirEILKVAK-------- 775
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 925 sKKPKKGTapppseqnkltvglVYVNENyygWKEQCLRVLQSKFDSQARlfapdeeINEALKNCSIGQETnfKQVQKL-- 1002
Cdd:PRK12300 776 -IKPKKVY--------------IYVAPD---WKYEVLEIAAENGDVKEA-------IKELMKDEELRKHG--KEVAKLaq 828
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 1003 -CMPFIKSKKDEARSVgphalnLKLPFGEMSVLEENLELIKRQVGLEhAEVLSASDEAARAKAGvhasmldktPPSPGEP 1081
Cdd:PRK12300 829 kIVKEVLKLDKEVRKL------ILKNIDEEEVLEEAKDFLEKELGVE-VEIYGADDPGKKKKKK---------KALPLKP 892
|
....*
gi 1002296767 1082 vAIFM 1086
Cdd:PRK12300 893 -AIYI 896
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
533-760 |
3.47e-71 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 239.84 E-value: 3.47e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 533 ALTDQWYITYGETEWKQKAVQCLEKMNTFSAETRNGFEHTLGwlnqwaCSRSFGLGTRIPWdeQFLVESLSDSTLYMAYY 612
Cdd:cd00812 127 KLLDQWFLKYSETEWKEKLLKDLEKLDGWPEEVRAMQENWIG------CSRQRYWGTPIPW--TDTMESLSDSTWYYARY 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 613 TIAHLLQNGNMYgkeissirpeqmtdevwdyvfcdgpapnsdippaLLSKMKLEFEYWYPFDIRVSGKDLIQNHLTFSIY 692
Cdd:cd00812 199 TDAHNLEQPYEG----------------------------------DLEFDREEFEYWYPVDIYIGGKEHAPNHLLYSRF 244
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002296767 693 NHTALLPE----HHWPRGFRCNGHLMLNSEKMSKSTGNFRTLRQAIEEFSSDATRFALADAGDgmDDANFVF 760
Cdd:cd00812 245 NHKALFDEglvtDEPPKGLIVQGMVLLEGEKMSKSKGNVVTPDEAIKKYGADAARLYILFAAP--PDADFDW 314
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
758-878 |
4.40e-43 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 152.36 E-value: 4.40e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 758 FVFETANAAILRLTKEIAWMEEVIAAESSLragPPSTYADHVFANEINIAVIETEKSYNAFMFRDALKLGFYDLQLARDE 837
Cdd:cd07959 1 FREEEANSAILRLERFYELAEELIETEGEL---EELTFIDRWLLSRLNRLIKETTEAYENMQFREALKEGLYELQNDLDW 77
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1002296767 838 YRLSCGaAGMNRELLWRFMEVQTRLITPICPHYAEHVWRNI 878
Cdd:cd07959 78 YRERGG-AGMNKDLLRRFIEVWTRLLAPFAPHLAEEIWHEL 117
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
48-242 |
7.24e-28 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 115.42 E-value: 7.24e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 48 KFFGNFPYPYMNGLLHLGHAFSLSKLEFGAAYQRLRGSNVLLPFAFHCTGMPIKASADKLSReaqqygyppafpevedds 127
Cdd:cd00812 1 KFYILVMFPYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIKIGR------------------ 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 128 saevadssqadnaasvvpdkfkskkskaaskvgmqkfqweimrgfglsdeeiakfqDPYHWLTYFPPLAKEDLKAFGLGC 207
Cdd:cd00812 63 --------------------------------------------------------DPEDWTEYNIKKMKEQLKRMGFSY 86
|
170 180 190
....*....|....*....|....*....|....*
gi 1002296767 208 DWRRSFITTDmnPFYDAFVRWQMRKLKKMGKVVKD 242
Cdd:cd00812 87 DWRREFTTCD--PEYYKFTQWLFLKLYEKGLAYKK 119
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
25-758 |
3.51e-27 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 118.28 E-value: 3.51e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 25 QKWWEESKVFEAEPGNKppGPGEKFFGNFPYPYMNGLLHLGHAFSLSKLEFGAAYQRLRGSNVLLPFAFHCTGMPIKASA 104
Cdd:pfam00133 3 YEFWDEQGYFKPELEKR--KGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 105 D-KLSREAQQygyppafpEVEDDSSAEVADssqadnaasvvpdkfkskkskaaskvgmqkFQWEIMrgfglsdEEIAKFQ 183
Cdd:pfam00133 81 EkKLGIKEKK--------TRHKYGREEFRE------------------------------KCREWK-------MEYADEI 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 184 dpyhwltyfpplaKEDLKAFGLGCDWRRSFITtdMNPFYDAFVRWQMRKLKKMGKVVKDMRYTIYSPLDGQPCADHDRAS 263
Cdd:pfam00133 116 -------------RKQFRRLGRSIDWDREYFT--MDPELEAAVWEVFVRLHDKGLIYRGKKLVNWSPALNTALSNLEVEY 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 264 GEGVQPQEYVlikmevvppfppKLKTMEGRNVYLAAATLRPETMYGQTNCWVLPDGKYgafeindtdvfiVTSRAALNLA 343
Cdd:pfam00133 181 KDVKGPSIHV------------AFPLADDEGASLVIWTTTPWTLPGNTAVAVNPEFDY------------VITGEGYILA 236
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 344 YQNLSRVPEKPT---CLMELSGCDLIGLPLKSPLAFNEIiyalPMLT---ILTDKGTGIVTSVPSDSPDDFmalqdlvak 417
Cdd:pfam00133 237 EALLKSLYKKGTdkkILEDFRGKELEGKEAIHPFVNREI----PIITddyVDMEFGTGAVHIAPAHGENDY--------- 303
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 418 pALRQKYGvkdewvlpfkvVPIINIpefgdksaekvcldlkiksqndkeklaeakrMTYLKGFTDGtmiVGEFNGRKVQE 497
Cdd:pfam00133 304 -EVGQRHN-----------LEVINP-------------------------------VDDDGTFTEE---APDFQGVYRFD 337
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 498 AKPLIKnKLLEEGTAVLYSEPEKkvMS-----RSGDECVVALTDQWYITYgeTEWKQKAVQCLEKMNTF--SAETRngFE 570
Cdd:pfam00133 338 ARKKIV-ELLTEKGLLLKIEPFT--HSypfcwRSGTPIIPRATPQWFVRM--DELADQALEAVEKVQFVpkSGEKR--YF 410
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 571 HTLGWLNQWACSRSFGLGTRIP-W-----DEQFLVESLSD----------STLYMAYYTIAHLLQNGNMYGKEissirpe 634
Cdd:pfam00133 411 NWLANIQDWCISRQRWWGHPIPaWvskdtEEVVCRGELFElvagrfeeegSIKWLHREAKDKLGYGKGTLEQD------- 483
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 635 qmtDEVWDYVFCDGPAPNS--DIPpallSKMKLEFEYWYPFDIRVSGKDLIQNHLTFSIYNHTALLPEhhwpRGFR---C 709
Cdd:pfam00133 484 ---EDVLDTWFSSGSWPFStlGWP----FVNTEEFKKFFPADMLLEGSDQTRGWFYRMIMLSTALTGS----VPFKnvlV 552
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|.
gi 1002296767 710 NGhLMLNSE--KMSKSTGNFRTLRQAIEEFSSDATRFALADAgDGMDDANF 758
Cdd:pfam00133 553 HG-LVRDEQgrKMSKSLGNVIDPLDVIDKYGADALRLWLANS-DYGRDINL 601
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
528-758 |
2.33e-26 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 110.97 E-value: 2.33e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 528 DECVVALTDQWYITYGEteWKQKAVQCLEKMNTFSAETRNGFEHTLGWLNQWACSRSFGLGTRIPWDeqfLVESLSDSTL 607
Cdd:cd00668 132 GTHPVRITEQWFFDMPK--FKEKLLKALRRGKIVPEHVKNRMEAWLESLLDWAISRQRYWGTPLPED---VFDVWFDSGI 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 608 YMAYYTIAhllqngnmygkeissiRPEqmtdevwdyvfcdgpapnsdippallskmKLEFEYWYPFDIRVSGKDLIQNHL 687
Cdd:cd00668 207 GPLGSLGY----------------PEE-----------------------------KEWFKDSYPADWHLIGKDILRGWA 241
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002296767 688 TFSIYNHTALLPEhHWPRGFRCNGHLMLN-SEKMSKSTGNFRTLRQAIEEFSSDATRFALADAGDGMDDANF 758
Cdd:cd00668 242 NFWITMLVALFGE-IPPKNLLVHGFVLDEgGQKMSKSKGNVIDPSDVVEKYGADALRYYLTSLAPYGDDIRL 312
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
19-930 |
9.82e-24 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 108.22 E-value: 9.82e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 19 KIQSDAQKWWEESKVFEAEP-GNKPPgpgekFFGNFPYPYMNGLLHLGHAFSLSKLEFGAAYQRLRGSNVLLPFAFHCTG 97
Cdd:TIGR00422 9 EVEKKWYKKWEKSGFFKPDGnSNKPP-----FCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTDHAG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 98 MPIKASADKLSREAQQygyppafpeVEDDssaevadssqadnaasvvpdkfkskkskaaskVGMQKFQWEIMRgfgLSDE 177
Cdd:TIGR00422 84 IATQVKVEKKLGAEGK---------TKHD--------------------------------LGREEFREKIWE---WKEE 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 178 EIAKFqdpyhwltyfpplaKEDLKAFGLGCDWRRSFITTD---MNPFYDAFVRWQmrklkKMGKVVKDMRYTIYSPLDGQ 254
Cdd:TIGR00422 120 SGGTI--------------KNQIKRLGASLDWSRERFTMDeglSKAVKEAFVRLY-----EKGLIYRGEYLVNWDPKLNT 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 255 PCADHDRASGEGVQPQEYVLIKMEvvppfppklktmEGRNVYLAAATLRPETMYGQTNCWVLPDGKYgafeindtdvfiv 334
Cdd:TIGR00422 181 AISDIEVEYKEVKGKLYYIRYPLA------------NGSKDYLVVATTRPETMFGDTAVAVHPEDER------------- 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 335 tsraalnlaYQNlsrvpekptclmelsgcdLIGLPLKSPLAFNEIiyalpmlTILTD------KGTGIVTSVPSDSPDDF 408
Cdd:TIGR00422 236 ---------YKH------------------LIGKKVILPLTGRKI-------PIIADeyvdmeFGTGAVKVTPAHDFNDY 281
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 409 malqdlvakpALRQKYGvkdewvlpfkvVPIINipefgdksaekvCLDLkiksqndkeklaeakrmtylkgftDGTM--I 486
Cdd:TIGR00422 282 ----------EWGKRHN-----------LEFIN------------ILDE------------------------DGLLneN 304
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 487 VGEFNGRKVQEAKPLIKNKLLEEGTAVLYSEPEKKV--MSRSGDECVVALTDQWYITYgeTEWKQKAVQCLE--KMNTFS 562
Cdd:TIGR00422 305 AGKYQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVgtCWRSGTVVEPLLSKQWFVKV--EKLADKALEAAEegEIKFVP 382
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 563 AETRNGFEHTLGWLNQWACSRSFGLGTRIP-WdeqFLVEslsDSTLYMAYYTIAHLLQNGNMYGKEIssirpEQMTDeVW 641
Cdd:TIGR00422 383 KRMEKRYLNWLRNIKDWCISRQLIWGHRIPvW---YCKE---CGEVYVAKEEPLPDDKTNTGPSVEL-----EQDTD-VL 450
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 642 DYVFcdgpapNSDIPPalLSKM-----KLEFEYWYPFDIRVSGKDLIQNHLTFSIYNHTALLPEHHWPRGFrCNGhlMLN 716
Cdd:TIGR00422 451 DTWF------SSSLWP--FSTLgwpdeTKDLKKFYPTDLLVTGYDIIFFWVARMIFRSLALTGQVPFKEVY-IHG--LVR 519
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 717 SE---KMSKSTGNFRTLRQAIEEFSSDATRFALADAGDGMDDANF--------------VFETANAAILRLT--KEIAWM 777
Cdd:TIGR00422 520 DEqgrKMSKSLGNVIDPLDVIEKYGADALRFTLASLVTPGDDINFdwkrvesarnflnkLWNASRFVLMNLSddLELSGG 599
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 778 EEviaaesslragpPSTYADHVFANEINIAVIETEKSYNAFMFRDALKL-------GFYDLQLARDEYRLSCGAAGMNRE 850
Cdd:TIGR00422 600 EE------------KLSLADRWILSKLNRTIKEVRKALDKYRFAEAAKAlyefiwnDFCDWYIELVKYRLYNGNEAEKKA 667
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 851 LLWR---FMEVQTRLITPICPHYAEHVWRNILRKEGFAIKAGWP--IAGTPDPTLRIANKYLQDSIVKFRKLlqKQESGS 925
Cdd:TIGR00422 668 ARDTlyyVLDKALRLLHPFMPFITEEIWQHFKEGADSIMLQSYPvvDAEFVDEEAEKAFELLKEIIVSIRNL--KAESNI 745
|
....*
gi 1002296767 926 KKPKK 930
Cdd:TIGR00422 746 PPNAP 750
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
25-891 |
3.14e-16 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 84.09 E-value: 3.14e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 25 QKWWEESKVFEaepgNKPPGPGEKFFGNFPYPYMNGLLHLGHAFSLSKLEFGAAYQRLRGSNVLLPFAFHCTGMPIKasa 104
Cdd:PRK13208 20 QKIWEEEGTYK----FDPDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFFPQGWDDNGLPTE--- 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 105 dklsREAQ-QYGyppafpeveddssaevadssqadnaasVVPDkfkskkskaasKVGMQKFQwEIMRgfGLSDEEIAKFq 183
Cdd:PRK13208 93 ----RKVEkYYG---------------------------IRKD-----------DISREEFI-ELCR--ELTDEDEKKF- 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 184 dpyhwltyfpplaKEDLKAFGLGCDWRRSFITtdMNPFY-----DAFVRwqmrkLKKMGKVVKDMRYTIYSPLDGQPCAD 258
Cdd:PRK13208 127 -------------RELWRRLGLSVDWSLEYQT--ISPEYrrisqKSFLD-----LYKKGLIYRAEAPVLWCPRCETAIAQ 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 259 HDrasgegvqpQEYvlikmevvppfppklKTMEGRNVYLaaatlrpetmygqtncwvlpdgkygAFEI-NDTDVFIVTSR 337
Cdd:PRK13208 187 AE---------VEY---------------REREGKLNYI-------------------------KFPVeDGEEIEIATTR 217
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 338 aalnlayqnlsrvPEkptcLmeLSGC-------------DLIGLPLKSPLAFNEI-IYALPMLTIltDKGTGIVtsvpsd 403
Cdd:PRK13208 218 -------------PE----L--LPACvavvvhpdderykHLVGKTAIVPLFGVEVpILADPLVDP--DFGTGAV------ 270
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 404 spddfMalqdlvakpalrqkygvkdewvlpfkvvpiinIPEFGDKS-----AEkvcLDLKIKSQNDKeklaeakrmtylk 478
Cdd:PRK13208 271 -----M--------------------------------ICTFGDKTdvtwwRE---LNLPTRIIIDE------------- 297
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 479 gftDGTM--IVGEFNGRKVQEAKPLIKNKLLEEGtaVLYsEPEK-----KVMSRSGD--ECVValTDQWYITYgeTEWKQ 549
Cdd:PRK13208 298 ---DGRMteAAGKLAGLTIEEARKKIVEDLKSGG--LLG-KQEPikhnvKFCERCDTplEILV--TRQWFIKV--LDLKE 367
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 550 KAVQCLEKMNTFSAETRNGFEHtlgWLNQ----WACSRSFGLGTRIP-W------------DEQFLVESLSDStlyMAYY 612
Cdd:PRK13208 368 ELLERGKEINWYPEHMRVRLEN---WIEGlnwdWCISRQRYFGTPIPvWyckdcghpilpdEEDLPVDPTKDE---PPGY 441
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 613 TIAHLLQNGnmygkeissIRPEqmTDeVWDYVFcdgpapNSDIPPALLSKMKLEFEYW---YPFDIRVSGKDLIQNHLTF 689
Cdd:PRK13208 442 KCPQCGSPG---------FEGE--TD-VMDTWA------TSSITPLIVTGWERDEDLFekvFPMDLRPQGHDIIRTWLFY 503
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 690 SI---YNHTALLPehhwprgFRcngHLMLNS-------EKMSKSTGNFRTLRQAIEEFSSDATRFALADAGDGMDdanFV 759
Cdd:PRK13208 504 TIlraYLLTGKLP-------WK---NIMISGmvldpdgKKMSKSKGNVVTPEELLEKYGADAVRYWAASARLGSD---TP 570
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 760 FETA-------------NAA--ILRLTKEIAWMEEVIAAEsslragppstyADHVFANEINIAVIETEKSYNAFMFRDAL 824
Cdd:PRK13208 571 FDEKqvkigrrlltklwNASrfVLHFSADPEPDKAEVLEP-----------LDRWILAKLAKVVEKATEALENYDFAKAL 639
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 825 KL-------GFYD--LQLARdeYRLSCGAAGMNRE----LLWRFMEVQTRLITPICPHYAEHVWRNIlrKEGFAIKAGWP 891
Cdd:PRK13208 640 EEiesffwhVFCDdyLELVK--SRAYGEDEEEEQKsaryTLYTVLDTLLRLLAPFLPFITEEVWSWL--YGGSVHRASWP 715
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
48-250 |
3.41e-12 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 68.60 E-value: 3.41e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 48 KFFGNFPYPYMNGLLHLGHAFSLSKLEFGAAYQRLRGSNVLLPFAFHCTGMPIKasadklsREAQQYGyppafpevedds 127
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIE-------LKAERKG------------ 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 128 saevadssqadnaasvvpdkfkskkskaaskvgmqkfqweimrGFGLSDEEIAKF-QDPYHWLTYFPPLAKEDLKAFGLG 206
Cdd:cd00668 62 -------------------------------------------GRKKKTIWIEEFrEDPKEFVEEMSGEHKEDFRRLGIS 98
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1002296767 207 CDWRRSFITTDmnPFYDAFVRWQMRKLKKMGKVVKDMRYTIYSP 250
Cdd:cd00668 99 YDWSDEYITTE--PEYSKAVELIFSRLYEKGLIYRGTHPVRITE 140
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
673-746 |
1.26e-11 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 65.29 E-value: 1.26e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1002296767 673 FDIRVSGKDLIQNHLTFSIYNHTALLPeHHWPRGFRCNGHLMLNSEKMSKSTGNFRTLRQAIEEFSSDATRFAL 746
Cdd:cd00672 129 FDIHGGGVDLIFPHHENEIAQSEAATG-KPFARYWLHTGHLTIDGEKMSKSLGNFITVRDALKKYDPEVLRLAL 201
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
797-930 |
4.29e-11 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 62.04 E-value: 4.29e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 797 DHVFANEINIAVIETEKSYNAFMFRDALKLGFYDLQLAR-DEY------RLSCGAAGMN-RELLWRFMEVQTRLITPICP 868
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLsDWYlelikdRLYGEEPDSRaQTTLYEVLETLLRLLAPFMP 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1002296767 869 HYAEHVWRNilrkeGFAIKAGWPI-AGTPDPTLRIANKYLQDSIVKFRKLLQKQESGSKKPKK 930
Cdd:pfam08264 81 FITEELWQK-----ESIHLAPWPEdAELEEAELEEAFELRQEIVQAIRKLRSELKIKKSLPLE 138
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
522-758 |
3.79e-10 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 63.03 E-value: 3.79e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 522 VMSRSGDECVVALTDQWYITYGETewKQKAVQCLEK--MNTFSAETRNGFEHtlgWLNQ---WACSRSFGLGTRIP-WDE 595
Cdd:cd00817 155 VCSRSGDVIEPLLKPQWFVKVKDL--AKKALEAVKEgdIKFVPERMEKRYEN---WLENirdWCISRQLWWGHRIPaWYC 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 596 QFLVESLSDSTLYMAYYTIAHLLQNGNmygkeiSSIRPEQMTDeVWDYVFcdgpapNSDIPPALLSK---MKLEFEYWYP 672
Cdd:cd00817 230 KDGGHWVVAREEDEAIDKAAPEACVPC------GGEELKQDED-VLDTWF------SSSLWPFSTLGwpeETKDLKKFYP 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 673 FDIRVSGKDLIQNHLTFSI---YNHTALLPehhWPRGFrCNGhLMLNSE--KMSKSTGNFRTLRQAIEEFSSDATRFALA 747
Cdd:cd00817 297 TSLLVTGHDIIFFWVARMImrgLKLTGKLP---FKEVY-LHG-LVRDEDgrKMSKSLGNVIDPLDVIDGYGADALRFTLA 371
|
250
....*....|.
gi 1002296767 748 DAGDGMDDANF 758
Cdd:cd00817 372 SAATQGRDINL 382
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
679-825 |
9.31e-10 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 62.44 E-value: 9.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 679 GKDLIQNHltfSIYnhtallpehhWP-----RGFR------CNGHLMLNSEKMSKSTGNFRTLRQAIEEFSSDATRFALA 747
Cdd:COG0143 289 GKDIIRFH---AII----------WPamlmaAGLPlpkkvfAHGFLTVEGEKMSKSRGNVIDPDDLLDRYGPDALRYYLL 355
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 748 DAGDGMDDANFVFEtanAAILRLTKEIA----------------WMEEVIAAESSLragppsTYADHVFANEINIAVIET 811
Cdd:COG0143 356 REVPFGQDGDFSWE---DFVARVNSDLAndlgnlasrtlsmihkYFDGKVPEPGEL------TEADEELLAEAEAALEEV 426
|
170
....*....|....
gi 1002296767 812 EKSYNAFMFRDALK 825
Cdd:COG0143 427 AEAMEAFEFRKALE 440
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
710-746 |
1.23e-09 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 62.04 E-value: 1.23e-09
10 20 30
....*....|....*....|....*....|....*..
gi 1002296767 710 NGHLMLNSEKMSKSTGNFRTLRQAIEEFSSDATRFAL 746
Cdd:COG0215 256 NGFLTVNGEKMSKSLGNFFTVRDLLKKYDPEVLRFFL 292
|
|
| tRNA-synt_1e |
pfam01406 |
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ... |
671-749 |
1.47e-08 |
|
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.
Pssm-ID: 396128 [Multi-domain] Cd Length: 301 Bit Score: 57.38 E-value: 1.47e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1002296767 671 YPFDIRVSGKDLIQNHLTFSIYNHTALLpEHHWPRGFRCNGHLMLNSEKMSKSTGNFRTLRQAIEEFSSDATRFALADA 749
Cdd:pfam01406 206 DQIDIHGGGIDLAFPHHENEIAQSEAAF-DKQLANYWLHNGHVMIDGEKMSKSLGNFFTIRDVLKRYDPEILRYFLLSV 283
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
666-775 |
6.04e-08 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 56.14 E-value: 6.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 666 EFEYWYPFDIRVS-----GKDLIQNHltfSIYNHTALLPE-HHWPRGFRCNGHLMLNSEKMSKSTGNFRTLRQAIEEFSS 739
Cdd:pfam09334 268 KWKEWWPNDPDTElvhfiGKDIIYFH---TIFWPAMLLGAgYRLPTTVFAHGYLTYEGGKMSKSRGNVVWPSEALDRFPP 344
|
90 100 110
....*....|....*....|....*....|....*.
gi 1002296767 740 DATRFALADAGDGMDDANFVFETanaAILRLTKEIA 775
Cdd:pfam09334 345 DALRYYLARNRPETKDTDFSWED---FVERVNSELA 377
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
660-758 |
1.26e-06 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 51.76 E-value: 1.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 660 LSKMKLEFEYWYPFDIRVS---GKDLIQNHltfSIYNHTALLPEHHW-PRGFRCNGHLMLNSEKMSKSTGNFRTLRQAIE 735
Cdd:cd00814 220 YNEEWGNSWWWKDGWPELVhfiGKDIIRFH---AIYWPAMLLGAGLPlPTRIVAHGYLTVEGKKMSKSRGNVVDPDDLLE 296
|
90 100
....*....|....*....|...
gi 1002296767 736 EFSSDATRFALADAGDGMDDANF 758
Cdd:cd00814 297 RYGADALRYYLLRERPEGKDSDF 319
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
679-835 |
1.44e-06 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 52.46 E-value: 1.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 679 GKDLIQNHLTFsiynhtallpehhWP-----RGFR------CNGHLMLNSEKMSKSTGNFRTLRQAIEEFSSDATRFALA 747
Cdd:PRK00133 291 GKDIIYFHTLF-------------WPamlegAGYRlptnvfAHGFLTVEGAKMSKSRGTFIWARTYLDHLDPDYLRYYLA 357
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 748 -DAGDGMDDANFVFEtanaailrltkeiAWMEEV----------IA------AESSLRAGPPSTYADHVFANEINIAVIE 810
Cdd:PRK00133 358 aKLPETIDDLDFNWE-------------DFQQRVnselvgkvvnFAsrtagfINKRFDGKLPDALADPELLEEFEAAAEK 424
|
170 180
....*....|....*....|....*
gi 1002296767 811 TEKSYNAFMFRDALKLGfydLQLAR 835
Cdd:PRK00133 425 IAEAYEAREFRKALREI---MALAD 446
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
20-726 |
5.25e-06 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 50.77 E-value: 5.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 20 IQSDAQKWWEESKVFEAEPGNKPPGPGEKFFGNFPYPYMNGLLHLGHAFSLSKLEFGAAYQRLRGSNVL-LPFAFHctgm 98
Cdd:PTZ00419 33 VESGWYEWWEKSGFFKPAEDAKSLNSGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLwVPGTDH---- 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 99 pikasadklsreaqqygyppafpeveddssAEVAdsSQadnaaSVVPDKFKSKKSKAASKVGMQKFQweimrgfglsdEE 178
Cdd:PTZ00419 109 ------------------------------AGIA--TQ-----VVVEKKLMKEENKTRHDLGREEFL-----------KK 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 179 IAKFQDPYhwltyfPPLAKEDLKAFGLGCDWRRSFITTD---MNPFYDAFVRwqmrkLKKMGKVVKDMRYTIYSpldgqp 255
Cdd:PTZ00419 141 VWEWKDKH------GNNICNQLRRLGSSLDWSREVFTMDeqrSKAVKEAFVR-----LYEDGLIYRDTRLVNWC------ 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 256 CADHDRASGEGVQPQEYVLIKMEVVPPFPPKL----------KTMEGRNVYLAAATLRPETMYGQTNCWVLPDGKygafe 325
Cdd:PTZ00419 204 CYLKTAISDIEVEFEEIEKPTKITIPGYDKKVevgvlwhfayPLEDSGQEEIVVATTRIETMLGDVAVAVHPKDE----- 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 326 indtdvfivtsRAAlnlayqnlsrvpekptclmelsgcDLIGLPLKSPLAFNEIIyalPMLT--ILTDK--GTGIVTSVP 401
Cdd:PTZ00419 279 -----------RYK------------------------KLHGKELIHPFIPDRKI---PIIAddELVDMefGTGAVKITP 320
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 402 SDSPDDFMAlqdlvakpALRQKygvkdewvlpfkvVPIINIpefgdksaekvcldlkiksqndkeklaeakrmtylkgFT 481
Cdd:PTZ00419 321 AHDPNDYEI--------AKRHN-------------LPFINI-------------------------------------FT 342
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 482 -DGTMIV--GEFNGRKVQEAKPLIKNKLLEEGtavLYSEPEKKVM-----SRSGDECVVALTDQWYITYgeTEWKQKAVQ 553
Cdd:PTZ00419 343 lDGKINEngGEFAGMHRFDCRRKIEEELKEMG---LLRDKVPNPMrlprcSRSGDIVEPMLIPQWYVNC--KDMAKRAVE 417
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 554 CLEK--MNTFSAETRNGFEHTLGWLNQWACSRSFGLGTRIPwDEQFLVESLSDSTLYMAYYTIAHLLQNG-----NMYGK 626
Cdd:PTZ00419 418 AVRNgeLKIIPSSHENVWYHWLENIQDWCISRQLWWGHRIP-AYRVISKGPETDPSDEEPWVVARSEEEAlekakKKFGL 496
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 627 EISSIRPEQMTDeVWDYVFCDG---------PAPNSDippallskmkleFEYWYPFDIRVSGKDLI----------QNHL 687
Cdd:PTZ00419 497 SEEDFELEQDED-VLDTWFSSGlfpfstlgwPDQTDD------------LQRFFPTSLLETGSDILffwvarmvmmSLHL 563
|
730 740 750 760
....*....|....*....|....*....|....*....|..
gi 1002296767 688 TFSIYNHTALLpehhwprgfrcngHLML---NSEKMSKSTGN 726
Cdd:PTZ00419 564 TDKLPFKTVFL-------------HAMVrdsQGEKMSKSKGN 592
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
25-111 |
5.76e-06 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 50.54 E-value: 5.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 25 QKWWEESKVFE--AEPGNkppgpGEKFFGNFPYPYMNGLLHLGHAfsLSKL--EFGAAYQRLRGSNVLLPFAFHCTGMPI 100
Cdd:PLN02843 13 QKLWEENQVYKrvSDRNN-----GESFTLHDGPPYANGDLHIGHA--LNKIlkDFINRYQLLQGKKVHYVPGWDCHGLPI 85
|
90
....*....|....*
gi 1002296767 101 K----ASADKLSREA 111
Cdd:PLN02843 86 ElkvlQSLDQEARKE 100
|
|
| PLN02946 |
PLN02946 |
cysteine-tRNA ligase |
671-746 |
7.40e-06 |
|
cysteine-tRNA ligase
Pssm-ID: 178532 [Multi-domain] Cd Length: 557 Bit Score: 49.93 E-value: 7.40e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1002296767 671 YPFDIRVSGKDLIQNHLTFSIYNHTALLPE---HHWPRgfrcNGHLMLNSEKMSKSTGNFRTLRQAIEEFSSDATRFAL 746
Cdd:PLN02946 276 HSFDIHGGGMDLVFPHHENEIAQSCAACCDsniSYWIH----NGFVTVDSEKMSKSLGNFFTIRQVIDLYHPLALRLFL 350
|
|
| PTZ00399 |
PTZ00399 |
cysteinyl-tRNA-synthetase; Provisional |
671-744 |
1.10e-05 |
|
cysteinyl-tRNA-synthetase; Provisional
Pssm-ID: 240402 [Multi-domain] Cd Length: 651 Bit Score: 49.64 E-value: 1.10e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1002296767 671 YPFDIRVSGKDLIQNHLTFSIYNHTALLPEHHWPRGFRCNGHLMLNSEKMSKSTGNFRTLRQAIEEFSSDATRF 744
Cdd:PTZ00399 267 DPIDIHSGGIDLKFPHHDNELAQSEAYFDKHQWVNYFLHSGHLHIKGLKMSKSLKNFITIRQALSKYTARQIRL 340
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
54-111 |
1.44e-05 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 48.78 E-value: 1.44e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1002296767 54 PYPYMNGLLHLGHAFSLSKLEFGAAYQRLRGSNVLLPFAFHCTGMP-----------IKASADKLSREA 111
Cdd:cd00817 8 PPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIAtqvvvekklgiEGKTRHDLGREE 76
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
19-114 |
1.46e-05 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 49.44 E-value: 1.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 19 KIQSDAQKWWEESKVFEAEPGNKPPGPGEKFFGNFPYPYMNGLlHLGHAFSLSKLEFGAAYQRLRGSNVLLPFAFHCTGM 98
Cdd:PLN02563 84 EIEPKWQRYWEENRTFRTPDDVDTSKPKFYVLDMFPYPSGAGL-HVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGL 162
|
90
....*....|....*.
gi 1002296767 99 PikasadklsreAQQY 114
Cdd:PLN02563 163 P-----------AEQY 167
|
|
| cysS |
PRK14536 |
cysteinyl-tRNA synthetase; Provisional |
673-789 |
2.36e-04 |
|
cysteinyl-tRNA synthetase; Provisional
Pssm-ID: 184731 [Multi-domain] Cd Length: 490 Bit Score: 44.91 E-value: 2.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 673 FDIRVSGKDLIQNHLTFSIYNHTALLPEHhWPRGFRCNGHLMLNSEKMSKSTGNFRTLRQAIEE-FSSDATRFALAdAGD 751
Cdd:PRK14536 234 CDIHIGGVDHIRVHHTNEIAQCEAATGKP-WVRYWLHHEFLLMNKGKMSKSAGQFLTLSSLQEKgFQPLDYRFFLL-GGH 311
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1002296767 752 GMDDANFVFE---TANAAILRLTKEIA-WMEEVIAAESSLRA 789
Cdd:PRK14536 312 YRSQLAFSWEalkTAKAARRSLVRRVArVVDAARATTGSVRG 353
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
54-114 |
4.38e-04 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 43.82 E-value: 4.38e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1002296767 54 PYPYMNGLLHLGHAFSLSKLEFGAAYQRLRGSNVLlpfafHCTGM-----PIKASADKLSREAQQY 114
Cdd:pfam09334 6 ALPYANGPPHLGHLYSYIPADIFARYLRLRGYDVL-----FVCGTdehgtPIELKAEKEGITPEEL 66
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
25-878 |
2.10e-03 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 42.37 E-value: 2.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 25 QKWWEESKVFE---AEPGNKPP-----GPgekffgnfpyPYMNGLLHLGHAfsLSKlefgaA-------YQRLRGSNVLL 89
Cdd:COG0060 26 LKFWEENDIYEksrEARAGRPKfvlhdGP----------PYANGDIHIGHA--LNK-----IlkdiivrYKTMRGFDVPY 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 90 PFAFHCTGMPIKASADKlsreaqQYGyppaFPEVEDDSsaevadssqadnaasvvpdkfkskkskaaskVGMQKFQWEim 169
Cdd:COG0060 89 VPGWDCHGLPIELKVEK------ELG----IKKKDIEK-------------------------------VGIAEFREK-- 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 170 rgfglSDEEIAKFQDpyHWltyfpplaKEDLKAFG-LGcDWRRSFITtdMNPFYDAFVrwqMRKLKKM---GKVVKDMRY 245
Cdd:COG0060 126 -----CREYALKYVD--EQ--------REDFKRLGvWG-DWDNPYLT--MDPEYEESI---WWALKKLyekGLLYKGLKP 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 246 TIYSPLDGQPCADH-----DRASgegvqPQEYVliKMEVVPPFPPKLktmeGRNVYLAAATlrpetmygqTNCWVLP--- 317
Cdd:COG0060 185 VPWCPRCGTALAEAeveykDVTS-----PSIYV--KFPVKDEKALLL----LEDAYLVIWT---------TTPWTLPanl 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 318 ------DGKYGAFEINDTDVFIVtsraALNLAYQNLSRV-PEKPTCLMELSGCDLIGLPLKSPLAFNEII-YALPMLT-- 387
Cdd:COG0060 245 avavhpDIDYVLVEVTGGERLIL----AEALVEAVLKELgIEDYEVLATFKGAELEGLRYEHPFYYVVGYdRAHPVILgd 320
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 388 -ILTDKGTGIVTSVPSDSPDDFmalqdLVAKpalrqKYGvkdewvLPFkVVPIinipefgdksaekvcldlkiksqNDKE 466
Cdd:COG0060 321 yVTTEDGTGIVHTAPGHGEDDF-----EVGK-----KYG------LPV-LNPV-----------------------DDDG 360
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 467 KlaeakrmtylkgFTDGtmiVGEFNGRKVQEAKPLIKNKLLEEGtAVLYSEP-----------EKKVMSRSgdecvvalT 535
Cdd:COG0060 361 R------------FTEE---APLFAGLFVKDANPAIIEDLKERG-ALLAREKithsyphcwrcKTPLIYRA--------T 416
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 536 DQWYItyGETEWKQKAVQCLEKMNTFSAETRNGFEhtlGWLNQ---WACSRSFGLGTRIP-WdeqflvesLSDST--LYM 609
Cdd:COG0060 417 PQWFI--SMDKLRDRALEAIEKVNWIPEWGEGRFG---NMLENrpdWCISRQRYWGVPIPiW--------VCEDCgeLHR 483
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 610 AYYTIAHLLQNGNMYGKEISSIRP--EQMTDEVWDYVFCDGPA-PNSDIppallskmkleFEYWypFDirvSGkdliqnh 686
Cdd:COG0060 484 TEEVIGSVAELLEEEGADAWFELDlhRPFLDETLKCPKCGGTMrRVPDV-----------LDVW--FD---SG------- 540
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 687 ltfSIynHTALL---PEHHWP-----------RG-----------------FR---CNGH-LMLNSEKMSKSTGNFRTLR 731
Cdd:COG0060 541 ---SM--HFAVLenrEELHFPadfylegsdqtRGwfysslltstalfgrapYKnvlTHGFvLDEDGRKMSKSLGNVVDPQ 615
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 732 QAIEEFSSDATRFALAdAGDGMDDanfvfetanaaiLRLTKEIawMEEVIAAESSLRagppSTY------------ADHV 799
Cdd:COG0060 616 EVIDKYGADILRLWVA-SSDYWGD------------LRFSDEI--LKEVRDVYRRLR----NTYrfllanlddfdpAEDA 676
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296767 800 FANE------------INIAVIETEKSYNAFMFRDALKL----------GFYdLQLARDeyRLSCGAAGMNREL-----L 852
Cdd:COG0060 677 VPYEdlpeldrwilsrLNELIKEVTEAYDNYDFHRAYRAlhnfcvedlsNWY-LDISKD--RLYTEAADSLDRRaaqttL 753
|
970 980
....*....|....*....|....*.
gi 1002296767 853 WRFMEVQTRLITPICPHYAEHVWRNI 878
Cdd:COG0060 754 YEVLETLVRLLAPILPFTAEEIWQNL 779
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
27-88 |
2.37e-03 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 42.19 E-value: 2.37e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1002296767 27 WWEESKVFEAEP-GNKPPgpgekFFGNFPYPYMNGLLHLGHAFSLSKLEFGAAYQRLRGSNVL 88
Cdd:PLN02381 112 WWEKSGYFGADAkSSKPP-----FVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNAL 169
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
54-114 |
5.77e-03 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 40.21 E-value: 5.77e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1002296767 54 PYPYMNGLLHLGHAFSLSKLEFGAAYQRLRGSNVllpfaFHCTGM-----PIKASADKLSREAQQY 114
Cdd:cd00814 7 ALPYVNGVPHLGHLYGTVLADVFARYQRLRGYDV-----LFVTGTdehgtKIEQKAEEEGVTPQEL 67
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
56-106 |
7.81e-03 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 39.91 E-value: 7.81e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1002296767 56 PYMNGLLHLGHAfsLSKL--EFGAAYQRLRGSNVLLPFAFHCTGMPIKASADK 106
Cdd:cd00818 10 PYANGLPHYGHA--LNKIlkDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEK 60
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
25-90 |
9.97e-03 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 40.09 E-value: 9.97e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002296767 25 QKWWEESKVFEAEPGNKPPgpgekffgnF----PYPYMNGLLHLGHAF------SLSKlefgaaYQRLRGSNVL-LP 90
Cdd:PRK05729 19 YQKWEEKGYFKPDDNSKKP---------FsiviPPPNVTGSLHMGHALnntlqdILIR------YKRMQGYNTLwLP 80
|
|
| |
