|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
122-554 |
1.15e-92 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 290.62 E-value: 1.15e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 122 KELLNLALPAIVGQAIDPVAQLLETAYIGRLG-PVELASAAVGVSVFNIISKLFNIPLLSiTTSFVAEDVARHDSDQfts 200
Cdd:cd13136 3 REILALALPAILSNITVPLLGLVDTAVVGHLGsAAYLGAVALGTTIFNTLFWLFGFLRMG-TTGLVAQALGAGDREE--- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 201 gnmssesggrkRLPSISSAILLAAAIGVIEasaLILGSEILLSIMGVSHAS-TMHSPAKLFLSLRALGAPAVVVSLAIQG 279
Cdd:cd13136 79 -----------AIALLVRALLLALAIGLLL---ILLQSPLLALALLLLGASaAVAALARQYLRIRILGAPAVLLNYVATG 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 280 IFRGLKDTKTPLLYSGLGNISAVLLLPFLVYSLNLGLNGAALATIASQYLGMFLLLWSLSKRAVLLPPKIED-----LDF 354
Cdd:cd13136 145 WFRGLQDTRTPLILQIVGNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGLWLLRRRVRLLGKSLSRrlpskAAL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 355 VGYIKSGGMLLGRTLSVLITMTLGTAMAARQGTIAMAAHQICLQVWLAVSLLSDALAVSAQALIASSFAKLDYEKVKEVT 434
Cdd:cd13136 225 KRLFKLNRDIFIRTLALLAAFLFFTALAARLGDVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVA 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 435 YYVLKIGLLVGAALALLLFASFGRIAELFSKDPMVLQIVGSGVLFVSASQPINALAFIFDGLHFGVSDFSYSASSMItVG 514
Cdd:cd13136 305 RRLLQWGLGLGVLLALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTRYLRNSML-VS 383
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 1002297707 515 AISSLFLLY-APKVFGLPGVWAGLALFMGLRMTAGFLRLGS 554
Cdd:cd13136 384 LAVFLPLLFlLVPLWGNHGLWLALILFMLLRGLTLALRLPR 424
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
118-551 |
3.76e-55 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 192.28 E-value: 3.76e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 118 GEIKKELLNLALPAIVGQAIDPVAQLLETAYIGRLGPVELASAAVGVSVFNIISKLFNIpLLSITTSFVAEDVARHDSDQ 197
Cdd:COG0534 4 GPILKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLLIALGIG-LGVGGTALVAQALGAGDREE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 198 FTSgnmssesggrkrlpSISSAILLAAAIGVIEASALILGSEILLSIMGVShaSTMHSPAKLFLSLRALGAPAVVVSLAI 277
Cdd:COG0534 83 ARR--------------VLGQALLLALLLGLLLTLLGLLFAPPLLRLLGAD--PEVLALARDYLRIILLGLPFLLLFNVL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 278 QGIFRGLKDTKTPLLYSGLGNISAVLLLPFLVYSLNLGLNGAALATIASQYLGMFLLLWSLSKRAVLLPPKIEDLDFVG- 356
Cdd:COG0534 147 NGILRGLGDTKTPMIIMLIGNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRPDRk 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 357 ----YIKSGGMLLGRTLSVLITMTLGTAMAARQGTIAMAAHQICLQVWLAVSLLSDALAVSAQALIASSFAKLDYEKVKE 432
Cdd:COG0534 227 ilkrILRIGLPAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARR 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 433 VTYYVLKIGLLVGAALALLLFASFGRIAELFSKDPMVLQIVGSGVLFVSASQPINALAFIFDGLHFGVSDFSYSASSMIT 512
Cdd:COG0534 307 AARLALLLALGIGLLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLL 386
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 1002297707 513 VGAISSLFLLY--APKVFGLPGVWAGLALFMGLRMTAGFLR 551
Cdd:COG0534 387 RLWLVRLPLAYllAFLGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
130-481 |
9.07e-45 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 161.64 E-value: 9.07e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 130 PAIVGQAIDPVAQLLETAYIGRLGPVELASAAVGvSVFNIISKLFNIPLLSITTSFVAEDVARHDSDQFTsgnmssesgg 209
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLG-SSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLG---------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 210 rkrlPSISSAILLAAAIGVIEASALILGSEILLSIMGVShaSTMHSPAKLFLSLRALGAPAVVVSLAIQGIFRGLKDTKT 289
Cdd:TIGR00797 70 ----RQAQQSLLLALLLGLPVLLVGYFFIDPLLSLMGAD--GEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKT 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 290 PLLYSGLGNISAVLLLPFLVYSL--NLGLNGAALATIASQYLgMFLLLWSLSKRAVLLPPKIEDL------DFVGYIKSG 361
Cdd:TIGR00797 144 PMYITLIGNVINIILNYILIFGKfgFLGIVGAALATVISYWL-MFLLLLYYIKKAKKIGLKWEGLlkpdweVLKRLLKLG 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 362 GMLLGRTLSVLITMTLGTAMAARQGTIAMAAHQICLQVWLAVSLLSDALAVSAQALIASSFAKLDYEKVKEVTYYVLKIG 441
Cdd:TIGR00797 223 LPIAFRVILESLSFALLALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLS 302
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1002297707 442 LLVGAALALLLFASFGRIAELFSKDPMVLQIVGSGVLFVS 481
Cdd:TIGR00797 303 LLLGLVLAIILILFREFIARLFTNDPEVLELAAIYLIFVA 342
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
122-551 |
1.17e-36 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 141.50 E-value: 1.17e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 122 KELLNLALPAIVGQAIDPVAQLLETAYIGRLGPVELASAAVGVSVFNIISKLFniplLSITTSFVAEdVARHdsdqFTSG 201
Cdd:cd13137 1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLLLVLN----MALGTGTVAL-VSQS----YGAG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 202 NMssesggRKRLPSISSAILLAAAIGVIEASALILGSEILLSIMGVShaSTMHSPAKLFLSLRALGAPAVVVSLAIQGIF 281
Cdd:cd13137 72 DY------ERARRALGQSLLLALLLSLPLALLGLLFAEPLLRLLGAD--PEVIALALTYLRIVLLGIPFFFLSLVGNAAL 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 282 RGLKDTKTPLLYSGLGNISAVLLLPFLVYSL----NLGLNGAALATIASQYLGMFLLLWSLSKRAVLLPPKIEDLDFV-G 356
Cdd:cd13137 144 RGAGDTKTPMYIMIIVNVLNIVLDYVLIFGLwgfpGLGVAGAALATVISRVVGALLLLFLLLRGRLPIKISFKGFRLDrK 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 357 YIK--------SGGMLLGRTLSVLITMtlgtAMAARQGTIAMAAHQICLQVWLAVSLLSDALAVSAQALIASSFAKLDYE 428
Cdd:cd13137 224 IIKkllriglpAGLEQLLRSLGFLVLL----AIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPD 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 429 KVKEVTYYVLKIGLLVGAALALLLFASFGRIAELFSKDPMVLQIVGSGVLFVSASQPINALAFIFDGLHFGVSD----FS 504
Cdd:cd13137 300 EARRYGKRALRLGVLFMGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDtrppLI 379
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 1002297707 505 YSASSMITVgAISSLFLLYAPKVFGLPGVWAGLALFMGLRMTAGFLR 551
Cdd:cd13137 380 INLISMWLV-RLPLAYLLGFVLGLGLTGIWLAMFVDTIVRAILLLYR 425
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
128-552 |
5.98e-27 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 113.57 E-value: 5.98e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 128 ALPAIVGQAIDPVAQLLETAYIGRLGPVELASAAVGVSVFNIISKLFNIpLLSITTSFVAEDVARHDSDqftsgnmsses 207
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALLIALGVG-LSVGTSALISQAIGAGDEE----------- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 208 ggrKRLPSISSAILLAAAIGVIEASALILGSEILLSIMGVSHAstMHSPAKLFLSLRALGAPAVVVSLAIQGIFRGLKDT 287
Cdd:cd12082 69 ---KARRVLVQSIVLAILLGLLLAALLLFFSPLILSLLGAEEE--VIELAATYLTILILGLPITFLGAVLSGILQGEGDT 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 288 KTPLLYSGLGNISAVLLLPFLVY---SLNLGLNGAALATIASQYLGMFLLLWSLSKRAVLLPPKIEDLD-----FVGYIK 359
Cdd:cd12082 144 RTAMIISVLSNLLNILLDPLLIFglgPPELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKpdlelLRRLLR 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 360 SGGMLLGRTLSVLITMTLGTA-MAARQGTIAMAAHQICLQVWLAVSLLSDALAVSAQALIASSFAKLDYEKVKEVTYYVL 438
Cdd:cd12082 224 IGLPSAIQNSLLSLGLLIIVAiVAAFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVAL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 439 KIGLLVGAALALLLFASFGRIAELFSKDPMVLQIVGSGVLFVSASQPINALAFIFDGLHFGVSDFSYSASSMITVGAISS 518
Cdd:cd12082 304 LIGLLIGAVLGLLILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVR 383
|
410 420 430
....*....|....*....|....*....|....*.
gi 1002297707 519 LFLLY--APKVFGLPGVWAGLALFMGLRMTAGFLRL 552
Cdd:cd12082 384 LPLAYvlAYLGLGLYGIWLALVISLILAALVLLLFF 419
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
120-534 |
7.32e-27 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 113.32 E-value: 7.32e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 120 IKKELLNLALPAIVGQAIDPVAQLLETAYIGRLGPVElASAAVGVSVfniisklfniPLLSITTSFVAedvarhdsdQFT 199
Cdd:cd13138 1 ILKTLLLFALPLLLSNLLQQLYNLVDLLIVGQFLGVA-ALAAVSNGS----------PIIFLLTAIGM---------GLS 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 200 SGNMS--SESGGRKRLP----SISSAILLAAAIGVIEASALILGSEILLSIMGVSHAStmHSPAKLFLSLRALGAPAVVV 273
Cdd:cd13138 61 MGGTIliSQYIGAKDEEkakkAVGTLLVLFLILGIVLTILGLLFAPPILRLMNTPAEI--LELAVSYLRICFLGIPFIFG 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 274 SLAIQGIFRGLKDTKTPLLYSGLGNISAVLLLPFLVYSLNLGLNGAALATIASQYLGMFLLLWSLSKRAVLLPPKIEDLD 353
Cdd:cd13138 139 YNAYSAILRGLGDSKTPLYFVIIACVLNIILDLLFIAVFHMGVAGAALATVIAQAISVLLALYYLRKKKLPFKLSLKDFR 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 354 FVGYIKSGGMLLG-----RTLSVLITMTLGTAMAARQGTIAMAAHQICLQVWLAVSLLSDALAVSAQALIASSFAKLDYE 428
Cdd:cd13138 219 FDKEILKEILKIGlpsalQQSLVSISFLIINSIVNSYGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIE 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 429 KVKEVTYYVLKIGLLVGAALALLLFASFGRIAELFSKDPMVLQIVGSGVLFVSASQPINALAFIFDGLHFGvsdFSYSAS 508
Cdd:cd13138 299 RAKKGLRTGIIISLIIGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRG---LGKTKF 375
|
410 420 430
....*....|....*....|....*....|...
gi 1002297707 509 SMItVGAISS-------LFLLYAPKVFGLPGVW 534
Cdd:cd13138 376 PMI-ISILRLwlvriplAYLLSRLTGLGLFGIW 407
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
118-544 |
3.24e-24 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 105.30 E-value: 3.24e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 118 GEIKKELLNLALPAIVGQAIDPVAQLLETAYIGRLGPVELAsaAVGVSVF--NIISKLFNIPllSITTS-FVAEDVARHD 194
Cdd:cd13140 1 GPILKTLLRLALPIMGTSFIQMAYNLTDMFWVGRLGSDAVA--AVGTAGFfvWLAYALALLS--KIGAQvKVSQSIGAKD 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 195 SDQftsgnmssesggRKRLpsISSAILLAAAIGVIEASALILGSEILLSIMGVSHASTmHSPAKLFLSLRALGAPAVVVS 274
Cdd:cd13140 77 EKE------------ARKY--ARNALQLNLLLGILYGLLLLLFAKPLIGFFNLGDAEV-ISLAITYLRIVALGLIFSFLN 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 275 LAIQGIFRGLKDTKTPLLYSGLGNISAVLLLPFLVYSLN----LGLNGAALATIASQyLGMFLLLWSLSKRAVLLPPKIE 350
Cdd:cd13140 142 PVFTGIFNALGDSKTPFIINAIGLVLNIILDPLLIFGFGpfpaLGVAGAALATVLAQ-AIVFLLFLYALKKKKGLFLKIR 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 351 DLDFVGYIKSGGML-------LGRTLSVLITMTLGtAMAARQGTIAMAAHQICLQV----WLAvsllSDALAVSAQALIA 419
Cdd:cd13140 221 ILKRPDRKYIKEILklglpvaLQSILFALISMILA-RIIASFGPVAIAAQKVGSQIesisWMT----AEGFSTALAAFVG 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 420 SSFAKLDYEKVKEVTYYVLKIGLLVGAALALLLFASFGRIAELFSKDPMVLQIVGSGVLFVSASQPINALAFIFDGLHFG 499
Cdd:cd13140 296 QNYGAGKYDRIRKGYKTALKIASAIGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRILGFSQLFMCLEITTTGAFNG 375
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 1002297707 500 VSDFSY-SASSMITVGAISSLFLLYAPKVFGLPGVWAGLALFMGLR 544
Cdd:cd13140 376 LGRTKPpAIISIVFNGLRIPLALLLSPTGLGLNGIWWAISISSILK 421
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
121-539 |
6.98e-23 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 101.42 E-value: 6.98e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 121 KKELLNLALPAIVGQAIDPVAQLLETAYIGRLGpvELASAAVGVS--VFNIISKLFNIplLSI-TTSFVAEDVARHDSDQ 197
Cdd:cd13134 2 KLSLFALAWPIFIELLLQMLLGTIDTFMLSRYS--DNAVAAVGVAnqILFLLILIFSF--ISTgTSILIAQYLGAKDKKK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 198 FTsgnmssesggrkrlPSISSAILLAAAIGVIEASALILGSEILLSIMGVSHASTMHspAKLFLSLRALGAPAVVVSLAI 277
Cdd:cd13134 78 AR--------------QIAGVALLFNLLLGLVFSLLLLFFGAELLRLMGLPPELLAL--GSTYLRIVGGSLFLQALSLTL 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 278 QGIFRGLKDTKTPLLYSGLGNISAVLLLPFLVYSL----NLGLNGAALATIASQYLGMFLLLWSLSKRAVLLPPKIEDLD 353
Cdd:cd13134 142 SAILRSHGRTKIPMYVSLIMNILNIVGNYLLIFGWfglpKLGVAGVAISTVISRAVGLVLLFILLFRKLKIRFRLKDLRP 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 354 FVG-----YIKSGGMLLGRTLSVLITMTLGTAMAARQGTIAMAAHQICLQVWLAVSLLSDALAVSAQALIASSFAKLDYE 428
Cdd:cd13134 222 FPKkllkkILKIGLPSAGEELSYNLSQTVITAFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFD 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 429 KVKEVTYYVLKIGLLVGAALALLLFASFGRIAELFSKDPMVLQIvGSGVLFVSAS-QPINALAFIFDGLHFGVSD----F 503
Cdd:cd13134 302 EAYKRVLKSLKIGLLVSLAVALLLALFREPILGLFTDDPEIIAL-GKTLLLISILlEPGRAFNIVLIGSLRAAGDarfpV 380
|
410 420 430
....*....|....*....|....*....|....*.
gi 1002297707 504 SYSASSMITVGAISSLFLLYAPKvFGLPGVWAGLAL 539
Cdd:cd13134 381 LIGIISMWGISVPLAYLLGIVLG-LGLLGVWIAFAA 415
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
118-539 |
1.01e-22 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 101.11 E-value: 1.01e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 118 GEIKKELLNLALPAIVGQAIDPVAQLLETAYIGRLGPVELAsaAVGVS---VFNIISklFNIPLLSITTSFVAEDVARHD 194
Cdd:cd13142 7 GSILRTLLKLAWPIIVSNLLQVAYNLADTFWLGRLGADAVA--APSISwplIFLFIS--LGGGLTVAGTALVAQYTGAGD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 195 SDqftsgnMSSESGGRkrlpSISSAILLAAAIGVIeasALILGSEILLSIMGVShaSTMHSPAKLFLSLRALGAPAVVVS 274
Cdd:cd13142 83 YD------KANKVAGQ----TFSFVIILSLILAVL---GYILSRPLLLLLIGAP--EEVYPLALAYLRIIFLGLPFMFIF 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 275 LAIQGIFRGLKDTKTPLLYSGLGNISAVLLLPFLVYSL----NLGLNGAALATIASQYLGMFLLLWSLSKRAVLLPPKIE 350
Cdd:cd13142 148 FVFNSLLRGIGDTKTPMKIMFGSVLLNVILDPLLIFGIgpfpGLGVAGAALATVISRGIAAVIGLYLLFKGRVGLKISLR 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 351 DL----DFVGYIksggMLLGRTLSV-LITMTLG----TAMAARQGTIAMAAHQICLQVWLAVSLLSDALAVSAQALIASS 421
Cdd:cd13142 228 DLkpdwEWLKKI----FRIGLPSSIeQSARALGftvmTALVAGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQN 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 422 FAKLDYEKVKEVTYYVLKIGLLVGAALALLLFASFGRIAELFSKDPMVLQIvgsGVLFVSasqpINALAFIFDGLHFGVS 501
Cdd:cd13142 304 LGAGQIDRAEEIVKKAALLIFLILVIGGVLAFLFAEPIVRVFINDPEVIKE---GADFLR----IVAPSFPFFGLFQVIN 376
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 1002297707 502 DFSYSASSMITVGAISSL----------FLLYAPKVFGLPGVWAGLAL 539
Cdd:cd13142 377 GAFRGSGHTLTAMIISILrlwviriplaYLLAYVLGLGVTGIWIAMAI 424
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
122-559 |
2.21e-20 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 93.75 E-value: 2.21e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 122 KELLNLALPAIVGQAIDPVAQLLETAYIGRLGPVELASAAVGVSVFNIISKLFnIPLLSITTSFVAEDVARHDSDQFTsg 201
Cdd:cd13133 5 REILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPAGVLYFAILMLF-FGLSSGVQVFVAQYNGAGRYSRIG-- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 202 nmssesggrkrlPSISSAILLAAAIGVIEASALILGSEILLSIMGvsHASTMHSPAKLFLSLRALGAPAVVVSLAIQGIF 281
Cdd:cd13133 82 ------------RVLWQGLYFSLLLAPLLALLSALAAPLLFLLLG--HSPEVQALEVEYFRIRILGAPFSLLGAALRAFF 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 282 RGLKDTKTPLLYSGLGNISAVLLLPFLVYS----LNLGLNGAALATIASQYLGMFLLLWSLSKRA------VLLPPKIED 351
Cdd:cd13133 148 SGIGRTRVVMVANLVMVVVNIVLDYALIFGklgfPAMGIAGAAIATVIAEAVSLLFFLLLLFRRKnrrrfgLRRAWRFDR 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 352 LDFVGYIKSGGMLLGRTLSVLITMTLGTAMAARQGTIAMAAHQICLQVWLAVSLLSDALAVSAQALIASSFAKLDYEKVK 431
Cdd:cd13133 228 ELLRRILRLGLPSGLQFFLDVGAFTVFFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAM 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 432 EVTYYVLKIGLLVGAALALLLFASFGRIAELFSKDPMVLQIVGSGV---LFVSASQPINALAFIFDGlhfGVSDFSYSAS 508
Cdd:cd13133 308 RVTRRGLKLALAYMLLLGILFLLFPELLLSIFTPGADFALIAELAVpllRFVAAYILFDALALVFAG---ALRGAGDTRF 384
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 1002297707 509 SMITVGAISSLFLLYA-----PKVFGLPGVWAGLALFMGLRMTAGFLRLgsRAGPW 559
Cdd:cd13133 385 VMLAELIVAWLYLLPPayllvVLGAGLAGAWTVETVYVIVLALIFLLRF--RSGKW 438
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
122-496 |
1.30e-16 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 82.16 E-value: 1.30e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 122 KELLNLALPAIVGQaidpVAQLL----ETAYIGRLGPVELASAAVGVSVFNIISkLFNIPLLSITTSFVAEDVARHDSDQ 197
Cdd:cd13131 3 RALLRLALPILIAQ----LAQMAmgfvDTVMAGRLGADDLAAVALGSSLWFPVF-TFGMGLLLAVTPLVAQAHGAGDRRR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 198 FTsgnmssesggrkrlPSISSAILLAAAIGVIeASALILGSEILLSIMGVShaSTMHSPAKLFLSLRALGAPAVVVSLAI 277
Cdd:cd13131 78 IR--------------RAVRQGLWLALLLSLP-LMLLLWLAPPILPLMGQE--PEVAAIARGYLLALAWGIPPALLFQVL 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 278 QGIFRGLKDTKTPLLYSGLGNISAVLLLPFLVYSL----NLGLNGAALATIASqYLGMFLLLWSLSKRAVLLPPKIEDLD 353
Cdd:cd13131 141 RSFLDALGRTRPAMVITLLALVLNIPLNYVLIFGKfglpALGGAGAGLATAIV-YWLMFLALAFYIRRHKRFRRYRLFAR 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 354 F-------VGYIKSGGMLLGRTLSVLITMTLGTA-MAARQGTIAMAAHQICLQVWLAVSLLSDALAVSAQALIASSFAKL 425
Cdd:cd13131 220 FwrpdwarLKELLRLGLPIGLTIFFEVSLFAAVAlLMGRLGTTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAG 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1002297707 426 DYEKVKEVTYYVLKIGLLVGAALALLLFASFGRIAELFSKDPMVLQIvGSGVLFVSasqpinALAFIFDGL 496
Cdd:cd13131 300 DPADARRAGLVGLGLGVGFAALTALLLLLFPEQIAGLYTNDPAVIAL-AASLLVFA------ALFQLFDGI 363
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
120-539 |
2.87e-16 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 81.02 E-value: 2.87e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 120 IKKELLNLALPAIVGQAIDPVAQLLETAYIGRL-GPveLASAAVGVSvfniisklfnIPLLSITTSFvaedvarhdsdQF 198
Cdd:cd13143 2 IGKLFLKFALPAIIGMLVNGLYNIVDGIFVGHGvGA--LALAAVNLV----------FPIIMLLMAL-----------GL 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 199 TSGN-MSSESG---GRKRLPS----ISSAILLAAAIGVIEASALILGSEILLSIMGVShaSTMHSPAKLFLSLRALGAPA 270
Cdd:cd13143 59 MIGVgGASLISrrlGAGDREKanriFSTALLLSLILGLLLTILGLLFLDPLLRLLGAS--GELLPYAVDYLRIILLGAPF 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 271 VVVSLAIQGIFRGLKDTKTPLLYSGLGNISAVLLLPFLVYSLNLGLNGAALATIASQYLGMFLLLWSLSKRAVLLPPK-- 348
Cdd:cd13143 137 TILSSVLNNLLRAEGKPKLAMLGMLIGAVLNIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYFFRGKSLLKLSll 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 349 --IEDLDFVGYIKSGGM--LLGRTLSVLITMTLGTAMAARQGTIAMAAHQICLQVWLAVSLLSDALAVSAQALIASSFAK 424
Cdd:cd13143 217 rfKLSLKIIKEILALGFpsFLMQLSSSVVTIVLNLTLLGYGGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGA 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 425 LDYEKVKEVTYYVLKIGLLVGAALALLLFASFGRIAELFSKDPMVLQIVGSGVlfvsasqPINALAFIFDGLHFGVSDF- 503
Cdd:cd13143 297 GNYDRVKQALKLALIVALIYGLVLFLILLLFPEQIVSLFTDDPELIALAARIL-------RIFLLAFPLAGINIVLSGYf 369
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 1002297707 504 ----SYSASSMITV---GAISSLFLLYAPKVFGLPGVWAGLAL 539
Cdd:cd13143 370 qaigKAKRAALLSLlrqGLFLIPLLLILPRLFGLDGIWLAFPL 412
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
118-539 |
7.02e-15 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 76.96 E-value: 7.02e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 118 GEIKKELLNLALPAIVGQAIDPVAQLLETAYIGRLGPVELASAA-VGVSVFNIISklFNIPLLSITTSFVAEDVARHDSD 196
Cdd:cd13149 5 GSIPRHLIKLTLPMIFGILAMLIFNLTDTFFVGKLGTKELAAISfTFPVVLFLNS--LTIGLGIGASAVISRAIGAGDRN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 197 QFtsgnmssesggrKRLpsISSAILLAAAIGVIEASALILGSEILLSIMGVShaSTMHSPAKLFLSLRALGAPAVVVSLA 276
Cdd:cd13149 83 KA------------KRL--ATDSLILSLLLSVIVSLLGLFTIPPLFSLLGAS--GEILPLIVEYMAIWYLGLVFLVLPMV 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 277 IQGIFRGLKDTKTPLLYSGLGNISAVLLLPFLVYSL----NLGLNGAALATIASQYLGMFLLLWSLSKRAVLLPPKI--- 349
Cdd:cd13149 147 GNAIIRATGDTKRPSLVMLGAALVNVILDPILIFGFgpipGMGIAGAAIATVISRALGLGAALYFLHYHHRLIDFSEpsl 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 350 -------EDLDFVGYIKSGGMLLGRTLSVLITmtlgtAMAARQGTIAMAAHQICLQVWLAVSLLSDALAVSAQALIASSF 422
Cdd:cd13149 227 kalfrswKDILSIGIPAALSNILTPLSAAFIT-----ALVATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNW 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 423 AKLDYEKVKEVTYYVLKIGLLVGAALALLLFASFGRIAELFSKDPMVLQIVGSGVLFVSASqpinalaFIFDGLHFgVSD 502
Cdd:cd13149 302 GAGQYERVQEGLKISLKFSLIYGAILGIVLALFAGWLASLFSAEPEVIELITLYLLIVPIG-------YGGLGILI-ITS 373
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 1002297707 503 FSYSA------SSMITVGAIsslFLLYAP------KVFGLPGVWAGLAL 539
Cdd:cd13149 374 ASFNAlgkplySLGLNLIRV---FLLYIPlayvgsHLLGFAGVFIGALA 419
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
118-464 |
2.11e-12 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 69.11 E-value: 2.11e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 118 GEIKKELLNLALPAIVGQAIDPVAQLLETAYIGRLGPVELAsaAVGVSvfniisklfnIPLLSITTSFvaedvarhdSDQ 197
Cdd:cd13147 5 GDPKKAIIKLSIPMIIAMLLQTLYNLVDAIWVAGLGADALA--AIGFV----------FPLFMIIIGL---------GNG 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 198 FTSGNMSSESG--GRKRLPSISSA----ILLAAAIGVIEASALILGSEILLSIMGVSHASTMhspAKLFLSLRALGAPAV 271
Cdd:cd13147 64 LGAGASSAISRriGAKDKEGADNAavhsILLGLIISIILTIVLLPFLEPILVLMGAGEVLDL---AVDYGRIIFLGSIFL 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 272 VVSLAIQGIFRGLKDTKTPLLYSGLGNISAVLLLPFLVYSLNLGLNGAALATIASQYL-GMFLLLWSLSKRAVLLPPKIE 350
Cdd:cd13147 141 IFNNVAYGILRGEGDTKRAMYAMVAGSILNIILDPIFIYTLGLGIAGAAWATVISMLIsSLVLLYWFFVKKDTYVSLSLK 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 351 DLDFVGYIKSGGMLLG-----RTLSVLITMTLGTAMAAR-QGTIAMAAHQIclqVWLAVSLL---SDALAVSAQALIASS 421
Cdd:cd13147 221 NFKFDKKIVKDILKVGipaslEQLIMSVLMIILNLILVIvAGTDGVAVYTA---GWRIVSFAiipLIGIATAVTSVTGAA 297
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1002297707 422 FAKLDYEKVKEVTYYVLKIGLLVGAALALLLFASFGRIAELFS 464
Cdd:cd13147 298 YGARNYEKLKTAYNYSIKLGLIIELIIAILIFIFAPQIAYLFT 340
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
122-544 |
2.85e-11 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 65.67 E-value: 2.85e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 122 KELLNLALPAIVGQAIDPVAQLLETAYIGRLGPVELASAAVGVSVFNIisklFNIPLLSITTSFVaedvarhdsdqftsG 201
Cdd:cd13132 3 KKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANV----TGFSILLGLASAL--------------D 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 202 NMSSESGGRKRLPSI------SSAILLAAAIGVieaSALILGSEILLSIMG----VSHAstmhspAKLFLSLRALGAPAV 271
Cdd:cd13132 65 TLCGQAFGAKNYKLVgvylqrALVILLLCCVPI---SLLWLNTEPILLLLGqdpeIARL------AGEYLRWLIPGLFAY 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 272 VVSLAI------QGIFrglkdtkTPLLYSGL-GNISAVLLLPFLVYSLNLGLNGAALATIASQYLGMFLLL--------- 335
Cdd:cd13132 136 ALFEPLkrylqaQGIV-------LPLVYISLvALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLlyiffskgh 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 336 ----WSLSKRAVLlppkiEDLDFVGY-IKSGGMLLGRTLSVLItMTLGTAMAarQGTIAMAAHQICLQVWLAVSLLSDAL 410
Cdd:cd13132 209 katwGGFSREAFR-----GWGPFLKLaIPSALMLCLEWWAFEI-LVLLAGLL--PGTVALAAQSICLTTTSLLYMIPLGI 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 411 AVSAQALIASSFAKLDYEKVKEVTYYVLKIGLLVGAALALLLFASFGRIAELFSKDPMVLQIVGSGVLFVSASQPINALA 490
Cdd:cd13132 281 SIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVAILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQ 360
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 1002297707 491 FIFDGLHFGvsdfsysaSSMITVGAISSLFLLYapkVFGLP-GVWAGLALFMGLR 544
Cdd:cd13132 361 AVLSGVLRG--------CGRQKLGAYVNLVAYY---LIGLPvGLLLAFVLGLGLK 404
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
118-483 |
6.52e-11 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 64.56 E-value: 6.52e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 118 GEIKKELLNLALPAIVGQAIDPVAQLLETAYIGRLGpvELASAAVGVSVfNIISKLFNIPL-LSI-TTSFVAEDVARHDS 195
Cdd:cd13139 10 GSLNRAIFLLAIPMVLEMVMESLFAVVDLYFVSRLG--ALAIATVGLTE-SVLTIVYSIAIgLSMaATALVARRIGEKDP 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 196 dqftsgnmssESGGRkrlpSISSAILLAAAIGVIEASALILGSEILLSIMGVSHASTMHspAKLFLSLRALGAPAVVVSL 275
Cdd:cd13139 87 ----------EGAGF----AAVQAILLGVALSLILSILGYFFAEDILSLMGASPAVIAE--GYGYTRIMFGGNGFIMLLF 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 276 AIQGIFRGLKDTKTPLLYSGLGNISAVLLLPFLVYSLN----LGLNGAALATIASQYLGMFLLLWSLSKRAVLLPPKIED 351
Cdd:cd13139 151 LINGIFRGAGDAAIAMRSLWLANGLNIILDPLFIFGLGpipaMGVTGAAIATTIGRSIGVLYQLYHLFKGKGRIQIRRRH 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 352 LDFV-GYIKS------GGML--LGRTLSVLITMTlgtaMAARQGTIAMAAHQICLQVWLAVSLLSDALAVSAQALIASSF 422
Cdd:cd13139 231 LKLDwAIIKKiikiavGGILqfLIASSSWIFLVR----IIAEFGSTALAGYTIAIRIIMFALLPAWGLSNAAATLVGQNL 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1002297707 423 AKLDYEKVKEVTYYVLKIGLLVGAALALLLFASFGRIAELFSKDPMVLQIVGSGVLFVSAS 483
Cdd:cd13139 307 GAGQPDRAEKSVWRAGKYNMVFLGIVSLVFFLFAEPLVSFFTTDPEVIAIAVEALRIISLG 367
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
118-498 |
1.67e-10 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 63.39 E-value: 1.67e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 118 GEIKKELLNLALPAIVGQAIDPVAQLLETAYIGRLGPVELASAAVGVSVFNIISKlFNIPLLSITTSFVAEDVARHDSDQ 197
Cdd:cd13145 5 GPIPKLIRKLAIPASVGFFFNTMFNVVDTFFAGKISTEALAALSLSFPIFFIIIA-IGVGIGTGTTALIGNALGAGDRRK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 198 ftsgnmssesGGRKRLPSISSAILLAAAIGVIEasalILGSEILLSIMGVSHASTmhSPAKLFLSLRALGAPAVVVSLAI 277
Cdd:cd13145 84 ----------ARRYAAQGLSFGIILAILLTVIG----LFAAPPLFRLLGAEGDYL--DLALEYMDVIFAGSIFFLLNFGL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 278 QGIFRGLKDTKTPLLYSGLGNISAVLLLPFLVYS----LNLGLNGAALATIASQYLGMFLLLWSLSKRAVLLPPKIEDL- 352
Cdd:cd13145 148 NGILNAQGDTKSYRNFLIIGFFLNIILDPLFIFGgggiPAMGVSGIALATIISQFIGMFYLLYKVRKSGIISGCRLRDFi 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 353 -DFVGYIKSGGMLLGRTLSvLITMTLG----TAMAARQGTIAMAAHQICLQVWLAVSLLSDALAVSAQALIASSFAKLDY 427
Cdd:cd13145 228 pRLDVYKEILKQGFPASLN-MMTIGLGifviTYFVGQFGDEAVAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKY 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1002297707 428 EKVKEVTYYVLKIGLLVGAALALLLFASFGRIAELFSKDPMVLQIvGSGVLfvsasqPINALAFIFDGLHF 498
Cdd:cd13145 307 DRVRETYKKALKYGFVIMVVATVFLLFFAEPLMSLFTNDPAVIAI-GAGYL------RIDALIFYAYVVLF 370
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
130-304 |
2.51e-10 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 59.12 E-value: 2.51e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 130 PAIVGQAIDPVAQLLETAYIGRLGPVELASAAVGVSVFNIISklfnIPLLSITTSfvaedvarhdsdqfTSGNMSSESGG 209
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIF----MFLLGLGTA--------------LTTLVGQALGA 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 210 RKRL---PSISSAILLAAAIGVIEASALILGSEILLSIMGVShaSTMHSPAKLFLSLRALGAPAVVVSLAIQGIFRGLKD 286
Cdd:pfam01554 63 GNFKragVALRQGLILGLLLSLPIALLVLLFSEPILSLFGQD--EEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGD 140
|
170
....*....|....*...
gi 1002297707 287 TKTPLLYSGLGNISAVLL 304
Cdd:pfam01554 141 TKPPMYINIISLLLNIPL 158
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
122-537 |
1.18e-09 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 60.77 E-value: 1.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 122 KELLNLALPAIVGQAIDPVAQLLETAYIGRLGPveLASAAVGV---SVFNIISKLFNIpllSITTS-FVAEDVARHDSDQ 197
Cdd:cd13135 1 KKINHIAIPLILQNLVSQLQMLVDRAFLGRISI--RYYSAVGNvttPFNTITGFLGSI---SIGFTiLGSQSVGAKDIKR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 198 FTSgnmssesggrkrlpSISSAILLAAAIGVIEASALILGSEILLSIMGVShastmhsPAKLFLSLRALGAPAVVVSL-- 275
Cdd:cd13135 76 IND--------------YAISSIVYNSIIGVILFLLWLFGARIIFVLFGVD-------GQILGYSINYVRIFSIYLLLlg 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 276 ---AIQGIFRGLKDTKtPLLYSGlgnISAVLLLPFLVYSL--------NLGLNGAALATIASQYLGM-FLLLWSLSKRAV 343
Cdd:cd13135 135 ilfTFSSILQGIGETK-PIMYGG---IIKNLLNVILDYVLifgnfgfpRLGIIGAAIATTIANVLNLiILVYLCRKIKKL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 344 --------LLPPKIEDldFVGYIKSGGMLLGRTLSVLITMTLGTAMAARQGTIAMAAHQICLQVWLAVSLLSDALAVSAQ 415
Cdd:cd13135 211 tfklsntkVLKANIRP--YKFTIKLGLPLGGEEFLWNIGNLAVIRILNRIGELALGIYTLVFGIENIVLMPMYGYSSAAL 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 416 ALIASSFAKLDYEKVKEVTYYVLKIGLLVGAALALLLFASFGRIAELFSKDPMVLQIVGSGVLFVSASQPINALAFIF-D 494
Cdd:cd13135 289 TLVGESIGKKDLKEALRIGNICLGLGLLIYIAAAIVFLAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVYgF 368
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 1002297707 495 GLH-FGVSDFSYSASSMITVGAISSLFLLYAPKVFGLPGVWAGL 537
Cdd:cd13135 369 AIRaIGDTKWMLYTQIIGTIIVVSVALLLIFVFKLGLAGVYITL 412
|
|
| PRK10367 |
PRK10367 |
DNA-damage-inducible SOS response protein; Provisional |
122-544 |
2.92e-09 |
|
DNA-damage-inducible SOS response protein; Provisional
Pssm-ID: 182413 [Multi-domain] Cd Length: 441 Bit Score: 59.37 E-value: 2.92e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 122 KELLNLALPAIVGQAIDPVAQLLETAYIGRL-GPVELASAAVGVSVfniISKLFNIpLLSITTSfvaedvarhdsdqfTS 200
Cdd:PRK10367 9 KALWRLALPMIFSNITVPLLGLVDTAVIGHLdSPVYLGGVAVGATA---TSFLFML-LLFLRMS--------------TT 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 201 GnMSSESGGRKRLPSISSA----ILLAAAIGVIEASALILGSEILLSIMGVSHAstMHSPAKLFLSLRALGAPAVVVSLA 276
Cdd:PRK10367 71 G-LTAQAFGAKNPQALARAlvqpLLLALGAGALIALLRTPLIDLALHIVGGSEA--VLEQARRFLEIRWLSAPASLANLV 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 277 IQGIFRGLKDTKTPLLYSGLGNISAVLLLPFLVYSLNLGLNGAALATIASQYLGMFLLLWSLSKRAVLLPPKIEDL---- 352
Cdd:PRK10367 148 LLGWLLGVQYARAPVILLVVGNILNIVLDLWLVMGLHMNVQGAALATVIAEYATLLIGLLMVRKVLKLRGISLEMLktaw 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 353 --DFVGYIKSGGMLLGRTLSVLITMTLGTAMAARQGTIAMAAHQICLQVWLAVSLLSDALAVSAQALIASSFAKLDYEKV 430
Cdd:PRK10367 228 rgNFRRLLALNRDIMLRSLLLQLCFGAITVLGARLGSDIIAVNAVLMTLLTFTAYALDGFAYAVEAHSGQAYGARDGSQL 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 431 KEVTYYVLKIGLLVGAALALLLFASFGRIAELFSKDPMvLQIVGSGVLFVSASQPINAL-AFIFDGLHFGVSDFSYSASS 509
Cdd:PRK10367 308 LDVWRAACRQSGIVALLFSLVYALAGEHIIALLTSLPQ-IQQLADRYLIWQVILPLVGVwCYLLDGMFIGATRAAEMRNS 386
|
410 420 430
....*....|....*....|....*....|....*
gi 1002297707 510 MITVGAISSLFLLYAPkVFGLPGVWAGLALFMGLR 544
Cdd:PRK10367 387 MAVAAAGFALTLLTLP-WLGNHGLWLALTVFLALR 420
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
122-348 |
1.08e-08 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 57.85 E-value: 1.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 122 KELLNLALPAIVGQAIDPVAQLLETAyigrlgpveLASAAV--GVSVFNIISKLFNIPL----LSITTSF---VAEDVAR 192
Cdd:COG0728 222 RRVLKLMLPALLGVSVSQINLLVDTI---------LASFLPegSVSALYYADRLYQLPLglfgVAIGTALlprLSRAAAA 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 193 HDSDQFTSgnmssesggrkrlpSISSAILLAAAIGVIEASALILGSEILLSIMGVSHASTMHSPAKLFLSLR--ALGAPA 270
Cdd:COG0728 293 GDLEEFRR--------------TLSRGLRLVLLLTLPAAVGLIVLAEPIVRLLFERGAFTAEDTALTALALAayALGLPA 358
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1002297707 271 VVVSLAIQGIFRGLKDTKTPLLYSGLGNISAVLLLPFLVYSLnlGLNGAALATIASQYLGMFLLLWSLSKRAVLLPPK 348
Cdd:COG0728 359 FALVKVLARAFYARQDTRTPVRIAVIAVVVNIVLNLLLVPPL--GHAGLALATSLSALVNALLLLVLLRRRLGGLPLR 434
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
118-483 |
2.77e-08 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 56.17 E-value: 2.77e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 118 GEIKKELLNLALPAIVGQAIDPVAQLLETAYIGRLGPVELASAAVGVSVFNIISKLFNIplLSI-TTSFVAEDVARHDSD 196
Cdd:cd13141 7 GSIPKHIISMALPIAIGMIIQTLYFLVDLYFVGQLGDAALAGVSLAGNVMFFVMALTQV--LNVgTAALVSHAVGRKDQG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 197 QFTSgnmssesggrkrlpSISSAILLAAAIGVIEASALILGSEILLSIMGVSHASTMHSPAKL--FLSLRALGAPAVVVS 274
Cdd:cd13141 85 EANA--------------VFNQSLLLAAVLGLVVLVLGYLFGRLYLETLAADAATVEAATTYLywFIPSLALQFILTVLG 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 275 LAIqgifRGLKDTKTPLLYSGLGNISAVLLLPFLVYSLN----LGLNGAALATIASQYLGMFLLLW-------SLSKRAV 343
Cdd:cd13141 151 AAL----RGTGIVKPFMVIQILAVLLNIILAPILITGWGtgraLGVAGAGLASSISVAIAVVLLLYyflrlekYLRLDLA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 344 LLPPKIEDLDFVgyIKSGGMLLGRTLSVLITMTLGTAMAARQGTIAMAAHQICLQVWLAVSLLSDALAVSAQALIASSFA 423
Cdd:cd13141 227 LWRPDLPTWKRL--LKIGLPSGGEFLLTFVYMAVIYWALRPFGAAAQAGFGIGSRIMQSLFLPAMAIAFAAPAIAGQNFG 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002297707 424 KLDYEKVKEVTYYVLKIGLLVGAALALLLFASFGRIAELFSKDPMV-------LQIVG-----SGVLFVSAS 483
Cdd:cd13141 305 AGNYDRVRETFRITAILTTALMLVLTLLCQLVPELLVTPFSDDAAViavaatfLRYVSwnfvaAGLVFTCSG 376
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
118-340 |
1.34e-07 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 54.01 E-value: 1.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 118 GEIKKELLNLALPAIVGQAIDPVAQLLETAYIGRLGPVELASAAVGVSVFNIIS----KLFNIPLlSITTSF-------V 186
Cdd:cd13124 220 KEILKELLSYAIPITLSSLILPLLQLIDSFTVPRRLQAAGLSESEATALYGILTgraqPLVQLPT-VIATALstslvpaI 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 187 AEDVARHDSDQFtsgnmssesggRKRlpsISSAILLAAAIGVIEASAL-ILGSEILLSIMGVSHASTMhspaklfLSLRA 265
Cdd:cd13124 299 SEAYAKGDKKEL-----------RRR---INQALRLTLLIGLPAAVGLaVLAEPINTLLFGDSEGGLI-------LQILA 357
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1002297707 266 LGAPAVVVSLAIQGIFRGLKDTKTPLLYSGLGNISAVLLLPFLVYslNLGLNGAALATIASQYLGMFLLLWSLSK 340
Cdd:cd13124 358 PSILFLSLQQVTAAILQGLGKVKIPVINLLIGLLVKIVLNYVLIP--IFGIYGAAIATVIGFLVAALLNLRALKK 430
|
|
| MATE_like_3 |
cd13148 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
118-395 |
1.41e-07 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240553 [Multi-domain] Cd Length: 441 Bit Score: 54.20 E-value: 1.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 118 GEIKKELLNLALPAIVGQAIDPVAQLLETAYIGRLGPVELASAAVgvsVFniisklfniPLLSITT--------SFVAED 189
Cdd:cd13148 8 APILPTLLRLALPNILALLVQTLVGLAETYFVGQLGTDALAGVAL---VF---------PLLMLTQmmsngamgGGVSSA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 190 VARhdsdqftsgnmsSESGGRKRLPS--ISSAILLAAAIGVIEASALILGSEILLSIMGVSHASTMHSPAKLFLSLraLG 267
Cdd:cd13148 76 IAR------------ALGAGDRERAEalVWHALVIALAGGLVFSLLFLLFGPALYRLLGGRGEALDAALAYSNVLF--SG 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 268 APAVVVSLAIQGIFRGLKDTKTPLLYSGLGNISAVLLLPFLVYSL----NLGLNGAALATIASQYLGMFLLLWSLSKRAV 343
Cdd:cd13148 142 AILIWLVNLLAAALRGTGNMRVPALVTLVGAVVQIPLSPGLILGWgplpRLGVAGAAVAAVLYYALAALVLLRYLASGRS 221
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1002297707 344 LLPPKIEDLDFVGY----IKSGGML--LGRTLSVLITMTLgTAMAARQGTIAMAAHQI 395
Cdd:cd13148 222 RLRLRLRALRLERRlfrdILRVGLLaaLSPLQTNLTVLLL-TGLVGRFGTAALAGYGI 278
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
122-341 |
3.44e-07 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 52.84 E-value: 3.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 122 KELLNLALPAIVGQAIDPVAQLLETAyigrlgpveLASAAV--GVSVFNIISKLFNIPL----LSITTSF---VAEDVAR 192
Cdd:cd13123 215 RRVLKLMLPALLGVSVSQINLLVDTI---------LASFLPegSISALYYADRLYQLPLgifgVAIATALlprLSRLAAA 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 193 HDSDQFTSgnmssesggrkrlpSISSAILLAAAIGVIEASALILGSEILLSIMGVSHASTMHSPAKLFLSLR--ALGAPA 270
Cdd:cd13123 286 GDLDEFRR--------------TLSRGLRLVLFLLLPAAVGLIVLAEPIVRLLFERGAFTAEDTLMTASALAayALGLPA 351
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1002297707 271 VVVSLAIQGIFRGLKDTKTPLLYSGLGNISAVLLLPFLVYSLnlGLNGAALATIASQYLGMFLLLWSLSKR 341
Cdd:cd13123 352 FALVKLLSRAFYALKDTKTPVKIAVIAVAVNILLNLLLIKPL--GHVGLALATSLSAWVNALLLLVLLRRR 420
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
122-336 |
5.43e-07 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 52.08 E-value: 5.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 122 KELLNLALPAIVGQAIDPVAQLLETAYIGRLGPVelASAAVGVSvfNIISKLFNIPLLSITTSFVAedvarhdsdqFTSG 201
Cdd:cd13138 225 KEILKIGLPSALQQSLVSISFLIINSIVNSYGVV--ASAAYGIA--NKINSFAFLPPSAIGQAVST----------FVAQ 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 202 NMSSESGGRKRLpSISSAILLAAAIGVIEASALILGSEILLSIMGVShaSTMHSPAKLFLSLRALGAPAVVVSLAIQGIF 281
Cdd:cd13138 291 NIGAGKIERAKK-GLRTGIIISLIIGLIIILLVFFFAPQLLGLFTSD--PEVIEIGAEYLRIYSIDYILFGILFVFNGLF 367
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1002297707 282 RGLKDTKTPLLysgLGNISAVLL-LPF---LVYSLNLGLNGAALATIASQYLGMFLLLW 336
Cdd:cd13138 368 RGLGKTKFPMI---ISILRLWLVrIPLaylLSRLTGLGLFGIWLAMPISNILSAIICII 423
|
|
| PRK10189 |
PRK10189 |
EmmdR/YeeO family multidrug/toxin efflux MATE transporter; |
158-568 |
1.78e-06 |
|
EmmdR/YeeO family multidrug/toxin efflux MATE transporter;
Pssm-ID: 182293 [Multi-domain] Cd Length: 478 Bit Score: 50.50 E-value: 1.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 158 ASAAVGVS-VFNIISKLFNIPLLSITTSFVAEDVARHDSDQftsgnmsSESGGRKRLPSIS-SAILLAAAIGVIeasali 235
Cdd:PRK10189 63 AMAGVGLAdSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRR-------ARAAARQSLVIMTlFAVLLAVLIHFF------ 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 236 lGSEILLSIMGvSHASTMHSPAKLFLSLRALGAPAVVVSLAIQGIFRGLKDTKTPLLYSGLGNISAVLLLPFLVYSL--- 312
Cdd:PRK10189 130 -GEQIIDLVAG-DATPEVKALALTYLELTVWSYPAAAITLIGSGALRGAGNTKIPLLINGGMNILNIIISSILIYGLfsw 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 313 -NLGLNGAALATIASQYLGMFLLLWSLSK---RAVLLPPKIEDLDFVGYIKSGGMLLGRTLSVLITM----TLGTAM-AA 383
Cdd:PRK10189 208 qGLGFVGAGLGLTISRYIGAVAIIWVLMIgfnPALRISLKSYFKPLNFAIIWEVMGIGIPASIESVLfnggKLLTQMfVA 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 384 RQGTIAMAAHQICLQVWLAVSLLSDALAVSAQALIASSFAKLDYEKVKEVTYYVLKIGLLVGAALALLLFASFGRIAELF 463
Cdd:PRK10189 288 GMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGTRLGKGQIAQAERQLRHVFWLSTLGLTAIAWLSAPFAGLLASFY 367
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 464 SKDPMVLQIVGSGVLFVSASQPINALAFIFDGLHFGVSDFSY----SASSM----ITVGAISSLFLlyapkVFGLPGVWA 535
Cdd:PRK10189 368 TQDPDVKHVVKILIWLNALFMPIWAASWVLPAGLKGARDARYamwvSMLGMwgcrVVAGYILGIML-----GFGVVGVWM 442
|
410 420 430
....*....|....*....|....*....|...
gi 1002297707 536 GLALFMGLRMTAGFLRLGSraGPWWFLHQKEPT 568
Cdd:PRK10189 443 GMFLDWAVRGVLFYWRMVS--GRWLWKYPRPEP 473
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
257-534 |
8.64e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 48.38 E-value: 8.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 257 AKLFLSLRALGAPAVVVSLAIQGIFRGLKDTKTPLLYSGLGNISAVLLLPFLVYSLN----LGLNGAALATIASQYLGMF 332
Cdd:cd13144 126 GYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMIAQLIGAIINIILDPILIFGLFgfpaMGIAGAAIATVIGQILAMF 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 333 LLLWSLSKRAVLLPPKI----EDLDFVGYIKSGGmllgrtLSVLITMTLGTAMAARQGTIAMAAHQICLQVW-------- 400
Cdd:cd13144 206 LAFFFLLRKNKDVQPDLrlfrPSLRIIKEIYAVG------LPSIIMQAISSVMVFGLNKILAGFGPTAVAVFgiyfklqs 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 401 ---LAVSLLSDALAvsaqALIASSFAKLDYEKVKEVTYYVLKIGLLVGAALALLLFASFGRIAELFSKDPMVLQIVGSGV 477
Cdd:cd13144 280 fvfMPVFGLNNGLI----PIVAYNYGAGNKDRIREAIKYAILIAVVIMLAGGLLFQLFPDQLLGLFNASEEMLAIGVPAL 355
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002297707 478 LFVSASQPINALAFIFDGLHFGVsdfSYSASSMItVGAISSLFLLYA-----PKVFGLPGVW 534
Cdd:cd13144 356 RIISLSFLFAALSIILSGLFQAL---GRGVYSLI-ISVARQLVVLLPlawllAKMFGLNGVW 413
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
210-381 |
9.99e-05 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 44.84 E-value: 9.99e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 210 RKRLPSISSAILLAAAIGVIEASALILgseiLLSIMGVSHASTMHSPAKLFlslrALGAPAVVVSLAIQGIFRGLKDTKT 289
Cdd:cd13128 69 KEKIREIISTSLVLKLILGILALLLLF----LFAFLIAFYDPELVLLLYIL----ALSLPFSALNSLFRGIFQGFEKMKY 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 290 PLLYSGLGNISaVLLLPFLVYSLNLGLNGAALATIASQYLGMFLLLWSLSKRAVLLPPKIEDLDFVGY-IKSGGMLLGRT 368
Cdd:cd13128 141 IVIARIIESVL-SLILALILVLLGGGLIGFALAYLIASVLSAILLLYIYRKKILLPKFFSFDLKLAKElLRFSIPLALSG 219
|
170
....*....|...
gi 1002297707 369 LSVLITMTLGTAM 381
Cdd:cd13128 220 IFSLIYTRIDTIM 232
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
122-326 |
1.39e-04 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 44.62 E-value: 1.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 122 KELLNLALPAIVGQAIDPVAQLLETAYIGRL-GPVELASAAVGVSVFNIISKLFnIPLLSITTSFVAEDVARHDSDQFTS 200
Cdd:cd12082 219 RRLLRIGLPSAIQNSLLSLGLLIIVAIVAAFgGAAALAAYTVAFRIASLAFMPA-LGLAQAALPVVGQNLGAGNFDRARR 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 201 GNMssesggrkrlpsisSAILLAAAIGVIEASALILGSEILLSIMGVSHASTMHspAKLFLSLRALGAPAVVVSLAIQGI 280
Cdd:cd12082 298 ITW--------------VALLIGLLIGAVLGLLILLFPEPILSLFTNDPEFLEL--AVSYLRILAIYYLFVGIGYVLQAG 361
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1002297707 281 FRGLKDTKTPLLYSGLGNISAVLLLPFLVYSLNLGLNGAALATIAS 326
Cdd:cd12082 362 FQAAGRTLKSLIVSLLSYWVVRLPLAYVLAYLGLGLYGIWLALVIS 407
|
|
| murJ_mviN |
TIGR01695 |
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously ... |
122-381 |
1.45e-04 |
|
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously MviN), a family of integral membrane proteins predicted to have ten or more transmembrane regions. Members have been suggested to act as a lipid II flippase, translocated a precursor of murein. However, it appears FtsW has that activity. Flippase activity for MurJ has not been shown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273763 [Multi-domain] Cd Length: 502 Bit Score: 44.62 E-value: 1.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 122 KELLNLALPAIVGQAIDPVAQLLETAYIGRLGPVELASAAVGVSVFNIISKLFNIPLLSITTSFVAEDVARHDSDQFtsg 201
Cdd:TIGR01695 223 KRFLKLFLPTTLGSSASQITLLINTALASFLEIGSVSALYYANRIYQLPLGIFGISLSTVLLPKLSRHASEGNWNEL--- 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 202 nmssesggrKRLPSISSAILLAAAIGVIeASALILGSEILLSIMGVS----HASTMHSPAklfLSLRALGAPAVVVSLAI 277
Cdd:TIGR01695 300 ---------RDLLNQGIRLSLLLTIPSS-FGLLILSIPIVSLLFERGafseEDTVMTATI---LAAYGLGLIFYSLQKVL 366
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 278 QGIFRGLKDTKTPLLYSGLG---NISAVLLLPFLvyslnLGLNGAALATIASQYLGMFLLLWSLSKRAVLLPPkIEDLDF 354
Cdd:TIGR01695 367 LRAFYARKDTRTPFINSVISvvlNALLSLLLIFP-----LGLVGIALATSAASMVSSVLLYLMLNRRLKGILP-FGVLKV 440
|
250 260
....*....|....*....|....*..
gi 1002297707 355 VGYIKSGGMLLGRTLSVLITMTLGTAM 381
Cdd:TIGR01695 441 LAKLVIASAIIGGVLYLIVSVSLGGVL 467
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
122-399 |
5.24e-04 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 42.81 E-value: 5.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 122 KELLNLALPAIVGQAIDPVAQLLETAYIGRLGPVELASAAVGVSVFNIISkLFNIPLLSITTSFVAedvARHDSDQFTSG 201
Cdd:PRK00187 10 KAILRLAGPLIASQLAHMLMVFTDTLMMGRLGPEALAGGGLGAASYSFVS-IFCVGVIAAVGTLVA---IRHGAGDIEGA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 202 NMSSESGgrkrlpsissaILLAAAIGVIEASALILGSEILLSImgvSHASTMHSPAKLFLSLRALGAPAVVVSLAIQGIF 281
Cdd:PRK00187 86 TRLAQAG-----------LWLAWLLALVAALLLWNLKPLLLLF---GQAPQNVDAAMQFLHLLPFALPGYLSFMALRGFT 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 282 RGLKDTKTPLLYSGLGNISAVLLLPFLVYSL----NLGLNGAALATiASQYLGMFLLL-----WSLSKRAVLLPPKIEDL 352
Cdd:PRK00187 152 SALGRAGPVMVISLAGAVANLLLNYALIEGWfglpKLGLMGIGLVT-ALVSNGMALALalyirRHPAYAAYPLRKGLSRP 230
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1002297707 353 DFvGYIKSG---GMLLGRTLSVLITM-TLGTAMAARQGTIAMAAHQICLQV 399
Cdd:PRK00187 231 SR-AALRELwrlGLPIGGTYAVEVGLfTFAALCMGALGSTQLAAHQIALQI 280
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
122-545 |
5.83e-04 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 42.49 E-value: 5.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 122 KELLNLALPAIVGQaidpVAQ----LLETAYIGRLGPVELASAAVGVSVFnIISKLFNIPLLSITTSFVAEDVArhdsdq 197
Cdd:PRK01766 12 RQLLALALPILLAQ----VAQtamgFVDTVMAGGVSATDLAAVAIGTSIW-LPVILFGHGLLLALTPIVAQLNG------ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 198 ftsgnmsseSGGRKRLP-SISSAILLAAAIGVIEASALILGSEILLSIMGVShaSTMHSPAKLFLSLRALGAPAVVVSLA 276
Cdd:PRK01766 81 ---------AGRRERIAhQVRQGLWLALFLSVLIMLVLYNAVPPILNMMNLE--PEVADIAVGYLHALLWGIPAYLLYQV 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 277 IQGIFRGLKDTKTPLLysgLGNISAVLLLPF---LVYSL----NLGLNGAALATiASQYLGMFLLLWSLSKRA-----VL 344
Cdd:PRK01766 150 LRSFIDGLGKTKPTMV---IGFLGLLINIPLnyiFIYGKfgfpELGGVGCGVAT-AIVYWVMFLAMLIYIKRArrfrdFR 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 345 LPPKIEDLDFVGYIKSGGMLLGRTLSVLITMTLGTAMA---ARQGTIAMAAHQICLQVWLAVSLLSDALAVSAQALIASS 421
Cdd:PRK01766 226 LFKGLYKPDWAVIKRLLKLGLPIGLAIFFEVSLFAVVTllvSPLGTVTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFE 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 422 FAKLDYEKVKEVTYYVLKIGLLVGAALALLLFASFGRIAELFSKDPMVLQIVGSGVLFVSASQPINALAFIFDGLHFGVS 501
Cdd:PRK01766 306 LGAGRTLDARQYAYIGLAVGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYK 385
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 502 D---------FSYSASSMItVGAISSLFLLYAPKvfglpGVWAGL-------ALFMGLRM 545
Cdd:PRK01766 386 DtrviffitfIAYWVLGLP-LGYILALTDPMGPF-----GFWIGLiigltaaAILLLLRL 439
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
118-503 |
6.49e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 42.39 E-value: 6.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 118 GEIKKELLNLALPAIVGQAIDPVAQLLETAYIGRLGPVELA-SAAVGVsVFNIISKLFNIP--LLSITTSFVAEDVARHD 194
Cdd:cd13146 4 GPISPLLIRLALPILIGQLFQLLYNITDTIWISMIDPSDPAlVGGIGL-VFPLGMIFLALGngIQVGVSSLLARAIGAQR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 195 SDQFTSgnmssesggrkrlpSISSAILLAAAIGVIEASALILGSEILLSIMGVSHASTMHSPAKLFLSLraLGAPAVVVS 274
Cdd:cd13146 83 AKELDQ--------------AADSGLALALLAATVIVVLGYIFAEPLLQLLGAKGLLLEYALEYFYYSL--PGVPFIMLI 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 275 LAIQGIFRGLKDTKTPLLYSGLGNISAVLLLPFLVYSLNLGLNGAALATIASQYLGMFLLLWSLSKRAVLLPPKIEdldf 354
Cdd:cd13146 147 GVLMGVLQGEGRTKYMMMAMLIGTVVNIVLDPILIFVFDMGVKGAALATVLAQAISLLYLLYVFLIGKSNVTIHIK---- 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 355 vgYIKSGGMLLGRTLSVLITMTLGTAMAA-----------RQGTIAMAAHQICLQVWLAVSLLSDALAVSAQALIASSFA 423
Cdd:cd13146 223 --LSNISSSVIVEILRVGLPQMLLQLISSisfliynriiiDIDPVAMTAFTLVGRLDQFILIPIFAISSALLTIAGQNWG 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 424 KLDYEKVKEVTYYVLKIGLLVGAALALLLFASFGRIAELFSKDPMVLQIVGSGVlfvsasqPINALAFIFDGLHFGVSDF 503
Cdd:cd13146 301 RGNYDRMLQILMTAVILGIVVVLVLVLGYVLVAPWLFSLFTTVPEVVAYAVLQV-------RTMALALPFVAISILVTEF 373
|
|
| MurJ |
pfam03023 |
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of ... |
122-349 |
2.45e-03 |
|
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of peptidoglycan precursor lipid II (undecaprenyl-pyrophosphate-linked N-acetyl glucosamine-N-acetyl muramic acid-pentapeptide) on the cytosolic face of the cell membrane. Lipid II is then translocated across the membrane and its glycopeptide moiety becomes incorporated into the growing cell wall mesh. MviN, renamed as MurJ, is a lipid II flippase essential for cell wall peptidoglycan synthesis. MurJ belongs to the MVF (mouse virulence factor) family of MOP superfamily transporters, which also includes the MATE (multidrug and toxic compound extrusion) transporter and eukaryotic OLF (oligosaccharidyl-lipid flippase) families. In addition to the canonical MOP transporter core consisting of 12 transmembrane helices (TMs), MurJ has two additional C-terminal TMs (13 and 14) of unknown function. Structural analysis indicates that the N lobe (TMs 1-6) and C lobe (TMs 7-14) are arranged in an inward-facing N-shape conformation, rather than the outward-facing V-shape conformation observed in all existing MATE transporter structures. Furthermore, a hydrophobic groove is formed by two C-terminal transmembrane helices, which leads into a large central cavity that is mostly cationic. Mutagenesis studies, revealed a solvent-exposed cavity that is essential for function. Mutation of conserved residues (Ser17, Arg18, Arg24, Arg52, and Arg255) at the proximal site failed to complement MurJ function, consistent with the idea that these residues are important for recognizing the diphosphate and/or sugar moieties of lipid II. It has also been suggested that the chloride ion in the central cavity and a zinc ion at the beginning of TM 7 might be functionally important.
Pssm-ID: 397249 [Multi-domain] Cd Length: 451 Bit Score: 40.74 E-value: 2.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 122 KELLNLALPAIVGQAIDPVAQLLETAYIGRLGPVELASAAVGVSVFNIISKLFNIPLLSITTSFVAEDVARHDSDQFtsg 201
Cdd:pfam03023 197 KRFLKLMLPTLLGVSVSQLNLLIDTFLASFLAPGSVSYLYYADRIYQLPLGIFGVSISTVLLPRLSRHAADGDWDEF--- 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 202 nmssesggrkrLPSISSAILLAAAIGVIEASALILGSEILLSIM---GVSHASTMHSPAKLfLSLRALGAPAVVVSLAIQ 278
Cdd:pfam03023 274 -----------RDLLDQAIRLTLLLMIPVSFGLLVLSIPIVSLLferGNFSPEDVTATAEV-LAAYALGLIPYALVKLLS 341
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1002297707 279 GIFRGLKDTKTPLLYSGLGNISAVLLLPFLVysLNLGLNGAALATIASQYLGMFLLLWSLSKRAVLLPPKI 349
Cdd:pfam03023 342 RVFYAREDTKTPFKISLISAVLNILLSLLLL--PPLGVAGLALATSLSSLIGLVFLYYILRKRLGGFDLRG 410
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
379-495 |
2.85e-03 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 38.70 E-value: 2.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002297707 379 TAMAARQGTIAMAAHQICLQVWLAVSLLSDALAVSAQALIASSFAKLDYEKVKEVTYYVLKIGLLVGAALALLLFASFGR 458
Cdd:pfam01554 17 TLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGLLLSLPIALLVLLFSEP 96
|
90 100 110
....*....|....*....|....*....|....*..
gi 1002297707 459 IAELFSKDPMVLQIVGSGVLFVSASQPINALAFIFDG 495
Cdd:pfam01554 97 ILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSG 133
|
|
| |
