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Conserved domains on  [gi|1002302199|ref|XP_015614482|]
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uncharacterized protein [Oryza sativa Japonica Group]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
172-439 2.33e-41

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 155.07  E-value: 2.33e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 172 VVLRGHTKVVSALAVDHTGSRVLSGSYDYTVCMYDfqgmnskLQSFRQLEPFEGHQ--VRSLSWSPTSDRFlcVTGSA-- 247
Cdd:COG2319   114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD-------LATGKLLRTLTGHSgaVTSVAFSPDGKLL--ASGSDdg 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 248 QAKIYDRDGLTLgefikgdmyirdLKNTKGHISGLTGGEWNPKSKeTILTSSEDGSIRLWDVsdfKSQKQVIKPKLARPm 327
Cdd:COG2319   185 TVRLWDLATGKL------------LRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVRLWDL---ATGKLLRTLTGHSG- 247

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 328 riPVTSCAWDHEGKRIVGGIGDGSIQLWTVKTGwgsrPDIHVEKTHTEDITGVKFSTDGQILLSRSMDSTLKIWDLRKmK 407
Cdd:COG2319   248 --SVRSVAFSPDGRLLASGSADGTVRLWDLATG----ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT-G 320

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1002302199 408 TPLKVFEDlpNHYAETNVAFSPDEQLIFTGTS 439
Cdd:COG2319   321 KLLRTLTG--HTGAVRSVAFSPDGKTLASGSD 350
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
172-439 2.33e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 155.07  E-value: 2.33e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 172 VVLRGHTKVVSALAVDHTGSRVLSGSYDYTVCMYDfqgmnskLQSFRQLEPFEGHQ--VRSLSWSPTSDRFlcVTGSA-- 247
Cdd:COG2319   114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD-------LATGKLLRTLTGHSgaVTSVAFSPDGKLL--ASGSDdg 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 248 QAKIYDRDGLTLgefikgdmyirdLKNTKGHISGLTGGEWNPKSKeTILTSSEDGSIRLWDVsdfKSQKQVIKPKLARPm 327
Cdd:COG2319   185 TVRLWDLATGKL------------LRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVRLWDL---ATGKLLRTLTGHSG- 247

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 328 riPVTSCAWDHEGKRIVGGIGDGSIQLWTVKTGwgsrPDIHVEKTHTEDITGVKFSTDGQILLSRSMDSTLKIWDLRKmK 407
Cdd:COG2319   248 --SVRSVAFSPDGRLLASGSADGTVRLWDLATG----ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT-G 320

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1002302199 408 TPLKVFEDlpNHYAETNVAFSPDEQLIFTGTS 439
Cdd:COG2319   321 KLLRTLTG--HTGAVRSVAFSPDGKTLASGSD 350
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 173-491 8.69e-40

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 147.48  E-value: 8.69e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 173 VLRGHTKVVSALAVDHTGSRVLSGSYDYTVCMYDFQGMNSKLQsfrqlepFEGHQ--VRSLSWSPTSDRFLCVTGSAQAK 250
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRT-------LKGHTgpVRDVAASADGTYLASGSSDKTIR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 251 IYDRDGLTLgefikgdmyIRDLKntkGHISGLTGGEWNPKSKeTILTSSEDGSIRLWDVSDFKsQKQVIKPKLArpmriP 330
Cdd:cd00200    77 LWDLETGEC---------VRTLT---GHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGK-CLTTLRGHTD-----W 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 331 VTSCAWDHEGKRIVGGIGDGSIQLWTVKTGwgsRPdIHVEKTHTEDITGVKFSTDGQILLSRSMDSTLKIWDLRKmktpL 410
Cdd:cd00200   138 VNSVAFSPDGTFVASSSQDGTIKLWDLRTG---KC-VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST----G 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 411 KVFEDLPNH-YAETNVAFSPDEQLIFTGTSiekdgenGGLLCFFDRRKLELVSRvgISPHYSVIRCL-WHPRINQVFATV 488
Cdd:cd00200   210 KCLGTLRGHeNGVNSVAFSPDGYLLASGSE-------DGTIRVWDLRTGECVQT--LSGHTNSVTSLaWSPDGKRLASGS 280


                  ...
gi 1002302199 489 GDK 491
Cdd:cd00200   281 ADG 283
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 367-402 1.14e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 1.14e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1002302199  367 IHVEKTHTEDITGVKFSTDGQILLSRSMDSTLKIWD 402
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
367-402 5.07e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 5.07e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1002302199 367 IHVEKTHTEDITGVKFSTDGQILLSRSMDSTLKIWD 402
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 280-410 5.02e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.62  E-value: 5.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 280 SGLTGGEWNPKSKETILTSSEDGSIRLWDVSdfKSQKQV-IKPKLARPMRIPVTSCawdhEGKRIVGGIGDGSIQLWTVK 358
Cdd:PLN00181  533 SKLSGICWNSYIKSQVASSNFEGVVQVWDVA--RSQLVTeMKEHEKRVWSIDYSSA----DPTLLASGSDDGSVKLWSIN 606

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1002302199 359 TGwgsrPDIHVEKTHTeDITGVKFSTD-GQILLSRSMDSTLKIWDLRKMKTPL 410
Cdd:PLN00181  607 QG----VSIGTIKTKA-NICCVQFPSEsGRSLAFGSADHKVYYYDLRNPKLPL 654
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
172-439 2.33e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 155.07  E-value: 2.33e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 172 VVLRGHTKVVSALAVDHTGSRVLSGSYDYTVCMYDfqgmnskLQSFRQLEPFEGHQ--VRSLSWSPTSDRFlcVTGSA-- 247
Cdd:COG2319   114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD-------LATGKLLRTLTGHSgaVTSVAFSPDGKLL--ASGSDdg 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 248 QAKIYDRDGLTLgefikgdmyirdLKNTKGHISGLTGGEWNPKSKeTILTSSEDGSIRLWDVsdfKSQKQVIKPKLARPm 327
Cdd:COG2319   185 TVRLWDLATGKL------------LRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVRLWDL---ATGKLLRTLTGHSG- 247

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 328 riPVTSCAWDHEGKRIVGGIGDGSIQLWTVKTGwgsrPDIHVEKTHTEDITGVKFSTDGQILLSRSMDSTLKIWDLRKmK 407
Cdd:COG2319   248 --SVRSVAFSPDGRLLASGSADGTVRLWDLATG----ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT-G 320

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1002302199 408 TPLKVFEDlpNHYAETNVAFSPDEQLIFTGTS 439
Cdd:COG2319   321 KLLRTLTG--HTGAVRSVAFSPDGKTLASGSD 350
WD40 COG2319
WD40 repeat [General function prediction only];
173-437 6.77e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 153.91  E-value: 6.77e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 173 VLRGHTKVVSALAVDHTGSRVLSGSYDYTVCMYDfqgmnskLQSFRQLEPFEGHQ--VRSLSWSPTSDRFlcVTGSA--Q 248
Cdd:COG2319   157 TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD-------LATGKLLRTLTGHTgaVRSVAFSPDGKLL--ASGSAdgT 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 249 AKIYDRDGLTLgefikgdmyirdLKNTKGHISGLTGGEWNPKSKeTILTSSEDGSIRLWDVSDfKSQKQVIKPKLARpmr 328
Cdd:COG2319   228 VRLWDLATGKL------------LRTLTGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLAT-GELLRTLTGHSGG--- 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 329 ipVTSCAWDHEGKRIVGGIGDGSIQLWTVKTGWgsrpDIHVEKTHTEDITGVKFSTDGQILLSRSMDSTLKIWDLRKMKT 408
Cdd:COG2319   291 --VNSVAFSPDGKLLASGSDDGTVRLWDLATGK----LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364

                         250       260       270
                  ....*....|....*....|....*....|
gi 1002302199 409 PLKvfedLPNHYAE-TNVAFSPDEQLIFTG 437
Cdd:COG2319   365 LRT----LTGHTGAvTSVAFSPDGRTLASG 390
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 173-491 8.69e-40

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 147.48  E-value: 8.69e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 173 VLRGHTKVVSALAVDHTGSRVLSGSYDYTVCMYDFQGMNSKLQsfrqlepFEGHQ--VRSLSWSPTSDRFLCVTGSAQAK 250
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRT-------LKGHTgpVRDVAASADGTYLASGSSDKTIR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 251 IYDRDGLTLgefikgdmyIRDLKntkGHISGLTGGEWNPKSKeTILTSSEDGSIRLWDVSDFKsQKQVIKPKLArpmriP 330
Cdd:cd00200    77 LWDLETGEC---------VRTLT---GHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGK-CLTTLRGHTD-----W 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 331 VTSCAWDHEGKRIVGGIGDGSIQLWTVKTGwgsRPdIHVEKTHTEDITGVKFSTDGQILLSRSMDSTLKIWDLRKmktpL 410
Cdd:cd00200   138 VNSVAFSPDGTFVASSSQDGTIKLWDLRTG---KC-VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST----G 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 411 KVFEDLPNH-YAETNVAFSPDEQLIFTGTSiekdgenGGLLCFFDRRKLELVSRvgISPHYSVIRCL-WHPRINQVFATV 488
Cdd:cd00200   210 KCLGTLRGHeNGVNSVAFSPDGYLLASGSE-------DGTIRVWDLRTGECVQT--LSGHTNSVTSLaWSPDGKRLASGS 280


                  ...
gi 1002302199 489 GDK 491
Cdd:cd00200   281 ADG 283
WD40 COG2319
WD40 repeat [General function prediction only];
173-491 1.99e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.12  E-value: 1.99e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 173 VLRGHTKVVSALAVDHTGSRVLSGSYDYTVCMYDfqgmnskLQSFRQLEPFEGHQ--VRSLSWSPTSDRFLCVTGSAQAK 250
Cdd:COG2319    73 TLLGHTAAVLSVAFSPDGRLLASASADGTVRLWD-------LATGLLLRTLTGHTgaVRSVAFSPDGKTLASGSADGTVR 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 251 IYDRDGLTLgefikgdmyirdLKNTKGHISGLTGGEWNPKSKeTILTSSEDGSIRLWDVSDFKSQKQVIKPKLarpmriP 330
Cdd:COG2319   146 LWDLATGKL------------LRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTLTGHTG------A 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 331 VTSCAWDHEGKRIVGGIGDGSIQLWTVKTGwgsrPDIHVEKTHTEDITGVKFSTDGQILLSRSMDSTLKIWDLRKmKTPL 410
Cdd:COG2319   207 VRSVAFSPDGKLLASGSADGTVRLWDLATG----KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT-GELL 281

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 411 KVFEDlpnHYAETN-VAFSPDEQLIFTGTsiekdgeNGGLLCFFDRRKLELVSrvGISPHYSVIRCL-WHPRINQVFATV 488
Cdd:COG2319   282 RTLTG---HSGGVNsVAFSPDGKLLASGS-------DDGTVRLWDLATGKLLR--TLTGHTGAVRSVaFSPDGKTLASGS 349


                  ...
gi 1002302199 489 GDK 491
Cdd:COG2319   350 DDG 352
WD40 COG2319
WD40 repeat [General function prediction only];
173-404 2.88e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 137.74  E-value: 2.88e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 173 VLRGHTKVVSALAVDHTGSRVLSGSYDYTVCMYDfqgmnskLQSFRQLEPFEGHQ--VRSLSWSPTSDRFLCVTGSAQAK 250
Cdd:COG2319   199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD-------LATGKLLRTLTGHSgsVRSVAFSPDGRLLASGSADGTVR 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 251 IYDRDGLTLgefikgdmyirdLKNTKGHISGLTGGEWNPKSKeTILTSSEDGSIRLWDVSDFKSQKQVikpklaRPMRIP 330
Cdd:COG2319   272 LWDLATGEL------------LRTLTGHSGGVNSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTL------TGHTGA 332

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1002302199 331 VTSCAWDHEGKRIVGGIGDGSIQLWTVKTGWgsrpDIHVEKTHTEDITGVKFSTDGQILLSRSMDSTLKIWDLR 404
Cdd:COG2319   333 VRSVAFSPDGKTLASGSDDGTVRLWDLATGE----LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 173-402 1.11e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.98  E-value: 1.11e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 173 VLRGHTKVVSALAVDHTGSRVLSGSYDYTVCMYDFQgmnsklqSFRQLEPFEGHQ--VRSLSWSPTSDRflcVTGSAQ-- 248
Cdd:cd00200    88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE-------TGKCLTTLRGHTdwVNSVAFSPDGTF---VASSSQdg 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 249 -AKIYD-RDGLTLGEFikgdmyirdlkntKGHISGLTGGEWNPKSKEtILTSSEDGSIRLWDVSDFKSQKQVikpklaRP 326
Cdd:cd00200   158 tIKLWDlRTGKCVATL-------------TGHTGEVNSVAFSPDGEK-LLSSSSDGTIKLWDLSTGKCLGTL------RG 217

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1002302199 327 MRIPVTSCAWDHEGKRIVGGIGDGSIQLWTVKTGwgsRPDIHVEKtHTEDITGVKFSTDGQILLSRSMDSTLKIWD 402
Cdd:cd00200   218 HENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTG---ECVQTLSG-HTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
173-359 7.27e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.44  E-value: 7.27e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 173 VLRGHTKVVSALAVDHTGSRVLSGSYDYTVCMYDfqgmnskLQSFRQLEPFEGHQ--VRSLSWSPTSDRFLCVTGSAQAK 250
Cdd:COG2319   241 TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD-------LATGELLRTLTGHSggVNSVAFSPDGKLLASGSDDGTVR 313

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 251 IYDRDGLTLgefikgdmyirdLKNTKGHISGLTGGEWNPKSKeTILTSSEDGSIRLWDVSDfksqKQVIKPKLARpmRIP 330
Cdd:COG2319   314 LWDLATGKL------------LRTLTGHTGAVRSVAFSPDGK-TLASGSDDGTVRLWDLAT----GELLRTLTGH--TGA 374

                         170       180
                  ....*....|....*....|....*....
gi 1002302199 331 VTSCAWDHEGKRIVGGIGDGSIQLWTVKT 359
Cdd:COG2319   375 VTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
323-439 4.47e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.69  E-value: 4.47e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 323 LARPMRIPVTSCAWDHEGKRIVGGIGDGSIQLWTVKTGwgsrPDIHVEKTHTEDITGVKFSTDGQILLSRSMDSTLKIWD 402
Cdd:COG2319    31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG----ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWD 106

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1002302199 403 LrkmKTPLKVFEDLPNHYAETNVAFSPDEQLIFTGTS 439
Cdd:COG2319   107 L---ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSA 140
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 367-501 9.32e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.88  E-value: 9.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 367 IHVEKTHTEDITGVKFSTDGQILLSRSMDSTLKIWDLRKMktplKVFEDLPNHYAE-TNVAFSPDEQLIFTGtsiekdGE 445
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG----ELLRTLKGHTGPvRDVAASADGTYLASG------SS 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1002302199 446 NGGLLCfFDRRKLELVSRvgISPHYSVIRCL-WHPRINQVFATVGDKkeggTHILYD 501
Cdd:cd00200    72 DKTIRL-WDLETGECVRT--LTGHTSYVSSVaFSPDGRILSSSSRDK----TIKVWD 121
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 367-402 1.14e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 1.14e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1002302199  367 IHVEKTHTEDITGVKFSTDGQILLSRSMDSTLKIWD 402
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
367-402 5.07e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 5.07e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1002302199 367 IHVEKTHTEDITGVKFSTDGQILLSRSMDSTLKIWD 402
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 173-206 5.30e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 5.30e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1002302199  173 VLRGHTKVVSALAVDHTGSRVLSGSYDYTVCMYD 206
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
173-206 4.31e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 4.31e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1002302199 173 VLRGHTKVVSALAVDHTGSRVLSGSYDYTVCMYD 206
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 280-410 5.02e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.62  E-value: 5.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 280 SGLTGGEWNPKSKETILTSSEDGSIRLWDVSdfKSQKQV-IKPKLARPMRIPVTSCawdhEGKRIVGGIGDGSIQLWTVK 358
Cdd:PLN00181  533 SKLSGICWNSYIKSQVASSNFEGVVQVWDVA--RSQLVTeMKEHEKRVWSIDYSSA----DPTLLASGSDDGSVKLWSIN 606

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1002302199 359 TGwgsrPDIHVEKTHTeDITGVKFSTD-GQILLSRSMDSTLKIWDLRKMKTPL 410
Cdd:PLN00181  607 QG----VSIGTIKTKA-NICCVQFPSEsGRSLAFGSADHKVYYYDLRNPKLPL 654
PTZ00420 PTZ00420
coronin; Provisional
 276-410 8.76e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 42.24  E-value: 8.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 276 KGHISGLTGGEWNPKSKETILTSSEDGSIRLWDVSDFKSQKQVIKPKlarpmriPVTSCAWDHEGKRIVGGIGDGSIQLW 355
Cdd:PTZ00420  122 KGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQINMPK-------KLSSLKWNIKGNLLSGTCVGKHMHII 194

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 356 TV-KTGWGSRPDIHVEKTHTEDITGVKFSTDGQILLSRSMDST----LKIWDLRKMKTPL 410
Cdd:PTZ00420  195 DPrKQEIASSFHIHDGGKNTKNIWIDGLGGDDNYILSTGFSKNnmreMKLWDLKNTTSAL 254
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 276-308 1.84e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.84e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1002302199  276 KGHISGLTGGEWNPKSKeTILTSSEDGSIRLWD 308
Cdd:smart00320   9 KGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
CDC55 COG5170
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];
374-457 2.17e-03

Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];


Pssm-ID: 227498 [Multi-domain]  Cd Length: 460  Bit Score: 41.17  E-value: 2.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002302199 374 TEDITGVKFSTDGQILLSRSMDsTLKIWDLRKMKTPLK---VFEDLPNH----------YAETNVAFSPDEQLI------ 434
Cdd:COG5170   280 VSSISDFKFSDNGRYILSRDYL-TVKIWDVNMAKNPIKtipMHCDLMDElndvyendaiFDKFEISFSGDDKHVlsgsys 358

                          90       100
                  ....*....|....*....|....*..
gi 1002302199 435 ----FTGTSIEKDGENGGLLCFFDRRK 457
Cdd:COG5170   359 nnfgIYPTDSSGFKDVGHVVNLADGSA 385
WD40 pfam00400
WD domain, G-beta repeat;
272-308 8.67e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 8.67e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1002302199 272 LKNTKGHISGLTGGEWNPKSKeTILTSSEDGSIRLWD 308
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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