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Conserved domains on  [gi|1002307001|ref|XP_015616890|]
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ankyrin repeat-containing protein At5g02620 [Oryza sativa Japonica Group]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 13788043)

ankyrin repeat (ANK) domain-containing protein may be involved in mediating protein-protein interactions; ankyrin repeat (ANK) domain-containing protein similar to Arabidopsis thaliana accelerated cell death 6 (ACD6), which is a regulator and an effector of salicylic acid signaling in the Arabidopsis defense response

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PGG pfam13962
Domain of unknown function; The PGG domain is named for the highly conserved sequence motif ...
 430-534 9.84e-33

Domain of unknown function; The PGG domain is named for the highly conserved sequence motif found at the startt of the domain. The function is not known.


:

Pssm-ID: 433609  Cd Length: 114  Bit Score: 121.51  E-value: 9.84e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 430 TSNT-SLVAILIATITFAAAFTLPGGY--SSDAGSQGLPIMARNVAFKAFLISDTLAMCASLAVAFICIIARWEDLDFLL 506
Cdd:pfam13962   7 ARNTlLLVATLIATVTFAAGFTPPGGYwqDDDGPHAGKPILAKNPAFKAFVISNAIAFFASLVAVVLLLSIVSDFLRSLP 86

                          90       100
                  ....*....|....*....|....*...
gi 1002307001 507 YYRSFTKKLMWFAYMATTTAFATGLYTV 534
Cdd:pfam13962  87 RKLRIGLKLLWVALLSMLVAFAAGSYRV 114
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
117-387 4.22e-23

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 99.64  E-value: 4.22e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 117 EVILKQDKHKCNALHHAICNGHKDLALELIATQPALSKDVNKYGESPMYIALMMRDSKFTDIFEKLLGIDgSSHSGTYGY 196
Cdd:COG0666    10 LLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGAD-INAKDDGGN 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 197 NALHAAIRNGNPDIAKRIIVERPNLATEeNKDGNTPIQLAVRWGKIDMLRVLLKHdrsqGYVINRKN--GYPLLLSAAHR 274
Cdd:COG0666    89 TLLHAAARNGDLEIVKLLLEAGADVNAR-DKDGETPLHLAAYNGNLEIVKLLLEA----GADVNAQDndGNTPLHLAAAN 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 275 GHVAVAREIIKYCPDAPYCKKDGWTCLHKAVKSGNMEFVEFILgepRLQKLVNMRSSKGKTALHYAIQKCDPKIVAALLD 354
Cdd:COG0666   164 GNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLL---EAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1002307001 355 KKIDLTILGSDGNAAAWELRDALDSAKTLNWNE 387
Cdd:COG0666   241 AGADLNAKDKDGLTALLLAAAAGAALIVKLLLL 273
Ank_2 pfam12796
Ankyrin repeats (3 copies);
51-146 6.35e-08

Ankyrin repeats (3 copies);


:

Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 50.50  E-value: 6.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001  51 LHISSMCGHLEFCKDVLSLPQDPTVKKKLlttvnvmNETPLLTAITSGHVTLAAFLLKYCHeqgfseviLKQDKHKCNAL 130
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKN-------GRTALHLAAKNGHLEIVKLLLEHAD--------VNLKDNGRTAL 65

                          90
                  ....*....|....*.
gi 1002307001 131 HHAICNGHKDLALELI 146
Cdd:pfam12796  66 HYAARSGHLEIVKLLL 81
 
Name Accession Description Interval E-value
PGG pfam13962
Domain of unknown function; The PGG domain is named for the highly conserved sequence motif ...
 430-534 9.84e-33

Domain of unknown function; The PGG domain is named for the highly conserved sequence motif found at the startt of the domain. The function is not known.


Pssm-ID: 433609  Cd Length: 114  Bit Score: 121.51  E-value: 9.84e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 430 TSNT-SLVAILIATITFAAAFTLPGGY--SSDAGSQGLPIMARNVAFKAFLISDTLAMCASLAVAFICIIARWEDLDFLL 506
Cdd:pfam13962   7 ARNTlLLVATLIATVTFAAGFTPPGGYwqDDDGPHAGKPILAKNPAFKAFVISNAIAFFASLVAVVLLLSIVSDFLRSLP 86

                          90       100
                  ....*....|....*....|....*...
gi 1002307001 507 YYRSFTKKLMWFAYMATTTAFATGLYTV 534
Cdd:pfam13962  87 RKLRIGLKLLWVALLSMLVAFAAGSYRV 114
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
117-387 4.22e-23

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 99.64  E-value: 4.22e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 117 EVILKQDKHKCNALHHAICNGHKDLALELIATQPALSKDVNKYGESPMYIALMMRDSKFTDIFEKLLGIDgSSHSGTYGY 196
Cdd:COG0666    10 LLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGAD-INAKDDGGN 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 197 NALHAAIRNGNPDIAKRIIVERPNLATEeNKDGNTPIQLAVRWGKIDMLRVLLKHdrsqGYVINRKN--GYPLLLSAAHR 274
Cdd:COG0666    89 TLLHAAARNGDLEIVKLLLEAGADVNAR-DKDGETPLHLAAYNGNLEIVKLLLEA----GADVNAQDndGNTPLHLAAAN 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 275 GHVAVAREIIKYCPDAPYCKKDGWTCLHKAVKSGNMEFVEFILgepRLQKLVNMRSSKGKTALHYAIQKCDPKIVAALLD 354
Cdd:COG0666   164 GNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLL---EAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1002307001 355 KKIDLTILGSDGNAAAWELRDALDSAKTLNWNE 387
Cdd:COG0666   241 AGADLNAKDKDGLTALLLAAAAGAALIVKLLLL 273
Ank_2 pfam12796
Ankyrin repeats (3 copies);
268-361 1.93e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.99  E-value: 1.93e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 268 LLSAAHRGHVAVAREIIKYCPDAPYCKKDGWTCLHKAVKSGNMEFVEFILGEPRLQklvnmRSSKGKTALHYAIQKCDPK 347
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN-----LKDNGRTALHYAARSGHLE 75

                          90
                  ....*....|....
gi 1002307001 348 IVAALLDKKIDLTI 361
Cdd:pfam12796  76 IVKLLLEKGADINV 89
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 199-380 3.21e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 59.21  E-value: 3.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 199 LHAAIRNGNPDIAKRIIVERPNLATEENkDGNTPIQLAVRWGKIDMLRVLLKhdrsQGYVINRKNGY---PLLLSAAHrG 275
Cdd:PHA02874  128 LHYAIKKGDLESIKMLFEYGADVNIEDD-NGCYPIHIAIKHNFFDIIKLLLE----KGAYANVKDNNgesPLHNAAEY-G 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 276 HVAVAREIIKYCPDAPYCKKDGWTCLHKAVKSgNMEFVEFILGeprlQKLVNMRSSKGKTALHYAIQ-KCDPKIVAALLD 354
Cdd:PHA02874  202 DYACIKLLIDHGNHIMNKCKNGFTPLHNAIIH-NRSAIELLIN----NASINDQDIDGSTPLHHAINpPCDIDIIDILLY 276

                         170       180
                  ....*....|....*....|....*.
gi 1002307001 355 KKIDLTILGSDGnaaawelRDALDSA 380
Cdd:PHA02874  277 HKADISIKDNKG-------ENPIDTA 295
Ank_2 pfam12796
Ankyrin repeats (3 copies);
51-146 6.35e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 50.50  E-value: 6.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001  51 LHISSMCGHLEFCKDVLSLPQDPTVKKKLlttvnvmNETPLLTAITSGHVTLAAFLLKYCHeqgfseviLKQDKHKCNAL 130
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKN-------GRTALHLAAKNGHLEIVKLLLEHAD--------VNLKDNGRTAL 65

                          90
                  ....*....|....*.
gi 1002307001 131 HHAICNGHKDLALELI 146
Cdd:pfam12796  66 HYAARSGHLEIVKLLL 81
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 267-358 6.51e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 45.77  E-value: 6.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 267 LLLSAAHRGHVAVAREIIKyCPDAPYCKKD--GWTCLHKAVKSGNMEFVEFILGEPRlqKLVN--MRSS--KGKTALHYA 340
Cdd:cd22192    20 PLLLAAKENDVQAIKKLLK-CPSCDLFQRGalGETALHVAALYDNLEAAVVLMEAAP--ELVNepMTSDlyQGETALHIA 96

                          90
                  ....*....|....*...
gi 1002307001 341 IQKCDPKIVAALLDKKID 358
Cdd:cd22192    97 VVNQNLNLVRELIARGAD 114
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 14-112 5.26e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 39.88  E-value: 5.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001  14 ELLEAAISGDTRSMKMKYMDSHDPTillGKNPQGNTCLHISSMCGHLEFCKDVLSLPQDPTVKKKllttvnvMNETPLLT 93
Cdd:PTZ00322   85 ELCQLAASGDAVGARILLTGGADPN---CRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDK-------DGKTPLEL 154

                          90
                  ....*....|....*....
gi 1002307001  94 AITSGHVTLAAFLLKYCHE 112
Cdd:PTZ00322  155 AEENGFREVVQLLSRHSQC 173
 
Name Accession Description Interval E-value
PGG pfam13962
Domain of unknown function; The PGG domain is named for the highly conserved sequence motif ...
 430-534 9.84e-33

Domain of unknown function; The PGG domain is named for the highly conserved sequence motif found at the startt of the domain. The function is not known.


Pssm-ID: 433609  Cd Length: 114  Bit Score: 121.51  E-value: 9.84e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 430 TSNT-SLVAILIATITFAAAFTLPGGY--SSDAGSQGLPIMARNVAFKAFLISDTLAMCASLAVAFICIIARWEDLDFLL 506
Cdd:pfam13962   7 ARNTlLLVATLIATVTFAAGFTPPGGYwqDDDGPHAGKPILAKNPAFKAFVISNAIAFFASLVAVVLLLSIVSDFLRSLP 86

                          90       100
                  ....*....|....*....|....*...
gi 1002307001 507 YYRSFTKKLMWFAYMATTTAFATGLYTV 534
Cdd:pfam13962  87 RKLRIGLKLLWVALLSMLVAFAAGSYRV 114
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
117-387 4.22e-23

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 99.64  E-value: 4.22e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 117 EVILKQDKHKCNALHHAICNGHKDLALELIATQPALSKDVNKYGESPMYIALMMRDSKFTDIFEKLLGIDgSSHSGTYGY 196
Cdd:COG0666    10 LLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGAD-INAKDDGGN 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 197 NALHAAIRNGNPDIAKRIIVERPNLATEeNKDGNTPIQLAVRWGKIDMLRVLLKHdrsqGYVINRKN--GYPLLLSAAHR 274
Cdd:COG0666    89 TLLHAAARNGDLEIVKLLLEAGADVNAR-DKDGETPLHLAAYNGNLEIVKLLLEA----GADVNAQDndGNTPLHLAAAN 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 275 GHVAVAREIIKYCPDAPYCKKDGWTCLHKAVKSGNMEFVEFILgepRLQKLVNMRSSKGKTALHYAIQKCDPKIVAALLD 354
Cdd:COG0666   164 GNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLL---EAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1002307001 355 KKIDLTILGSDGNAAAWELRDALDSAKTLNWNE 387
Cdd:COG0666   241 AGADLNAKDKDGLTALLLAAAAGAALIVKLLLL 273
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
143-423 3.00e-21

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 94.25  E-value: 3.00e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 143 LELIATQPALSKDVNKYGESPMYIALMMRDSKFTDIFEKLLGIDGSSHSGTYGYNALHAAIRNGNPDIAKRIIVERPNLA 222
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 223 TEENKDGNTPIQLAVRWGKIDMLRVLLKHdrsqGYVINRKN--GYPLLLSAAHRGHVAVAREIIKYCPDAPYCKKDGWTC 300
Cdd:COG0666    81 NAKDDGGNTLLHAAARNGDLEIVKLLLEA----GADVNARDkdGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTP 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 301 LHKAVKSGNMEFVEFIL--GEPrlqklVNMRSSKGKTALHYAIQKCDPKIVAALLDKKIDLTILGSDGN-----AAAWEL 373
Cdd:COG0666   157 LHLAAANGNLEIVKLLLeaGAD-----VNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKtaldlAAENGN 231

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1002307001 374 RDALDSAKTLNWNEVSMLMIKADPPNAKSVYNLHEEAKEKLINASRKDAR 423
Cdd:COG0666   232 LEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAA 281
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
119-327 2.30e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 80.00  E-value: 2.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 119 ILKQDKHKCNALHHAICNGHKDLALELIAtQPALSKDVNKYGESPMYIALMMRDskfTDIFEKLL--GIDgSSHSGTYGY 196
Cdd:COG0666    80 INAKDDGGNTLLHAAARNGDLEIVKLLLE-AGADVNARDKDGETPLHLAAYNGN---LEIVKLLLeaGAD-VNAQDNDGN 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 197 NALHAAIRNGNPDIAKRIIvERPNLATEENKDGNTPIQLAVRWGKIDMLRVLLKHDRSqgyvINRKN--GYPLLLSAAHR 274
Cdd:COG0666   155 TPLHLAAANGNLEIVKLLL-EAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD----VNAKDndGKTALDLAAEN 229

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1002307001 275 GHVAVAREIIKYCPDAPYCKKDGWTCLHKAVKSGNMEFVEFILGEPRLQKLVN 327
Cdd:COG0666   230 GNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAAL 282
Ank_2 pfam12796
Ankyrin repeats (3 copies);
268-361 1.93e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.99  E-value: 1.93e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 268 LLSAAHRGHVAVAREIIKYCPDAPYCKKDGWTCLHKAVKSGNMEFVEFILGEPRLQklvnmRSSKGKTALHYAIQKCDPK 347
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN-----LKDNGRTALHYAARSGHLE 75

                          90
                  ....*....|....
gi 1002307001 348 IVAALLDKKIDLTI 361
Cdd:pfam12796  76 IVKLLLEKGADINV 89
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-250 2.99e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 67.67  E-value: 2.99e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001   1 MAACAASTATIDWELLEAAISGDTRSMKMKYMDSHDPTILlgKNPQGNTCLHISSMCGHLEFCKDVLSLPQDPTVKkkll 80
Cdd:COG0666    43 ALLALALADALGALLLLAAALAGDLLVALLLLAAGADINA--KDDGGNTLLHAAARNGDLEIVKLLLEAGADVNAR---- 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001  81 ttvNVMNETPLLTAITSGHVTLAAFLLkychEQGFSevILKQDKHKCNALHHAICNGHKDLALELIAtQPALSKDVNKYG 160
Cdd:COG0666   117 ---DKDGETPLHLAAYNGNLEIVKLLL----EAGAD--VNAQDNDGNTPLHLAAANGNLEIVKLLLE-AGADVNARDNDG 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 161 ESPMYIALMMRDskfTDIFEKLL--GIDgSSHSGTYGYNALHAAIRNGNPDIAKRIIvERPNLATEENKDGNTPIQLAVR 238
Cdd:COG0666   187 ETPLHLAAENGH---LEIVKLLLeaGAD-VNAKDNDGKTALDLAAENGNLEIVKLLL-EAGADLNAKDKDGLTALLLAAA 261

                         250
                  ....*....|..
gi 1002307001 239 WGKIDMLRVLLK 250
Cdd:COG0666   262 AGAALIVKLLLL 273
Ank_2 pfam12796
Ankyrin repeats (3 copies);
199-286 5.32e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 56.28  E-value: 5.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 199 LHAAIRNGNPDIAKRIIVERPNlATEENKDGNTPIQLAVRWGKIDMLRVLLKHDRSQgyviNRKNGYPLLLSAAHRGHVA 278
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGAD-ANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN----LKDNGRTALHYAARSGHLE 75


                  ....*...
gi 1002307001 279 VAREIIKY 286
Cdd:pfam12796  76 IVKLLLEK 83
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 199-380 3.21e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 59.21  E-value: 3.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 199 LHAAIRNGNPDIAKRIIVERPNLATEENkDGNTPIQLAVRWGKIDMLRVLLKhdrsQGYVINRKNGY---PLLLSAAHrG 275
Cdd:PHA02874  128 LHYAIKKGDLESIKMLFEYGADVNIEDD-NGCYPIHIAIKHNFFDIIKLLLE----KGAYANVKDNNgesPLHNAAEY-G 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 276 HVAVAREIIKYCPDAPYCKKDGWTCLHKAVKSgNMEFVEFILGeprlQKLVNMRSSKGKTALHYAIQ-KCDPKIVAALLD 354
Cdd:PHA02874  202 DYACIKLLIDHGNHIMNKCKNGFTPLHNAIIH-NRSAIELLIN----NASINDQDIDGSTPLHHAINpPCDIDIIDILLY 276

                         170       180
                  ....*....|....*....|....*.
gi 1002307001 355 KKIDLTILGSDGnaaawelRDALDSA 380
Cdd:PHA02874  277 HKADISIKDNKG-------ENPIDTA 295
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 99-358 4.14e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 58.91  E-value: 4.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001  99 HVTLAAFLLKYCHEQGfsEVILKQDKHKCNALHHAICNGHKDLaLELIATQpalSKDVNKY--GESPMYIALMMRDSKFT 176
Cdd:PHA03100   10 SRIIKVKNIKYIIMED--DLNDYSYKKPVLPLYLAKEARNIDV-VKILLDN---GADINSStkNNSTPLHYLSNIKYNLT 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 177 DIFE--KLLGIDGSSHSGTY--GYNALHAAIRN--GNPDIAKRIIVERPNLaTEENKDGNTPIQLAVRWGKID--MLRVL 248
Cdd:PHA03100   84 DVKEivKLLLEYGANVNAPDnnGITPLLYAISKksNSYSIVEYLLDNGANV-NIKNSDGENLLHLYLESNKIDlkILKLL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 249 LKHdrsqGYVINRKNGYPLLLSaaHRGHVAVAREIikycpdapyckkdGWTCLHKAVKSGNMEFVEFILgepRLQKLVNM 328
Cdd:PHA03100  163 IDK----GVDINAKNRVNYLLS--YGVPINIKDVY-------------GFTPLHYAVYNNNPEFVKYLL---DLGANPNL 220

                         250       260       270
                  ....*....|....*....|....*....|
gi 1002307001 329 RSSKGKTALHYAIQKCDPKIVAALLDKKID 358
Cdd:PHA03100  221 VNKYGDTPLHIAILNNNKEIFKLLLNNGPS 250
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
43-231 5.48e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 57.66  E-value: 5.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001  43 KNPQGNTCLHISSMCGHLEFCKDVLSLPQDPTVKkkllttvNVMNETPLLTAITSGHVTLAAFLLkychEQGFSevILKQ 122
Cdd:COG0666   116 RDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQ-------DNDGNTPLHLAAANGNLEIVKLLL----EAGAD--VNAR 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 123 DKHKCNALHHAICNGHKDLALELIAtQPALSKDVNKYGESPMYIALMMRDSKFTDIFEKLLGIDgsSHSGTYGYNALHAA 202
Cdd:COG0666   183 DNDGETPLHLAAENGHLEIVKLLLE-AGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL--NAKDKDGLTALLLA 259

                         170       180
                  ....*....|....*....|....*....
gi 1002307001 203 IRNGNPDIAKRIIVERPNLATEENKDGNT 231
Cdd:COG0666   260 AAAGAALIVKLLLLALLLLAAALLDLLTL 288
Ank_2 pfam12796
Ankyrin repeats (3 copies);
233-317 9.01e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 52.81  E-value: 9.01e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 233 IQLAVRWGKIDMLRVLLKHDRSQGyvINRKNGYPLLLSAAHRGHVAVAREIIKYCpdAPYCKKDGWTCLHKAVKSGNMEF 312
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADAN--LQDKNGRTALHLAAKNGHLEIVKLLLEHA--DVNLKDNGRTALHYAARSGHLEI 76


                  ....*
gi 1002307001 313 VEFIL 317
Cdd:pfam12796  77 VKLLL 81
Ank_2 pfam12796
Ankyrin repeats (3 copies);
173-263 1.33e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 52.43  E-value: 1.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 173 SKFTDIFEKLLGIDGSSHSGT-YGYNALHAAIRNGNPDIAKRIIverPNLATEENKDGNTPIQLAVRWGKIDMLRVLLKH 251
Cdd:pfam12796   7 NGNLELVKLLLENGADANLQDkNGRTALHLAAKNGHLEIVKLLL---EHADVNLKDNGRTALHYAARSGHLEIVKLLLEK 83

                          90
                  ....*....|..
gi 1002307001 252 drsqGYVINRKN 263
Cdd:pfam12796  84 ----GADINVKD 91
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 198-361 3.11e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 56.15  E-value: 3.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 198 ALHAAIRNGNPDIAKRI--IVERPNLateENKDGNTPIQLAVRWGKIDMLRVLLKHDRSQGYvinrknGYPLLLSAAH-- 273
Cdd:PHA02875    5 ALCDAILFGELDIARRLldIGINPNF---EIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDV------KYPDIESELHda 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 274 --RGHVAVAREII---KYCPDAPYckKDGWTCLHKAVKSGNMEFVEFILgepRLQKLVNMRSSKGKTALHYAIQKCDPKI 348
Cdd:PHA02875   76 veEGDVKAVEELLdlgKFADDVFY--KDGMTPLHLATILKKLDIMKLLI---ARGADPDIPNTDKFSPLHLAVMMGDIKG 150

                         170
                  ....*....|...
gi 1002307001 349 VAALLDKKIDLTI 361
Cdd:PHA02875  151 IELLIDHKACLDI 163
Ank_2 pfam12796
Ankyrin repeats (3 copies);
51-146 6.35e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 50.50  E-value: 6.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001  51 LHISSMCGHLEFCKDVLSLPQDPTVKKKLlttvnvmNETPLLTAITSGHVTLAAFLLKYCHeqgfseviLKQDKHKCNAL 130
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKN-------GRTALHLAAKNGHLEIVKLLLEHAD--------VNLKDNGRTAL 65

                          90
                  ....*....|....*.
gi 1002307001 131 HHAICNGHKDLALELI 146
Cdd:pfam12796  66 HYAARSGHLEIVKLLL 81
Ank_4 pfam13637
Ankyrin repeats (many copies);
264-317 6.74e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.50  E-value: 6.74e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1002307001 264 GYPLLLSAAHRGHVAVAREIIKYCPDAPYCKKDGWTCLHKAVKSGNMEFVEFIL 317
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_2 pfam12796
Ankyrin repeats (3 copies);
130-215 1.39e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 46.65  E-value: 1.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 130 LHHAICNGHKDLALELIaTQPALSKDVNKYGESPMYIALMmrdSKFTDIFEKLLGIDGSSHSgTYGYNALHAAIRNGNPD 209
Cdd:pfam12796   1 LHLAAKNGNLELVKLLL-ENGADANLQDKNGRTALHLAAK---NGHLEIVKLLLEHADVNLK-DNGRTALHYAARSGHLE 75


                  ....*.
gi 1002307001 210 IAKRII 215
Cdd:pfam12796  76 IVKLLL 81
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 160-370 4.70e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 49.22  E-value: 4.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 160 GESPMYIALMMRDSKFTDIFEKLLGIDGSSHSGTYgyNALHAAIRNGNPDIAKRIIVERPNLATEENKDGNTPIQLAVRW 239
Cdd:PHA02875   35 GISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIE--SELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATIL 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 240 GKIDMLRVLLKHdrsqgyvinrkngyplllsaahrghvavareiiKYCPDAPycKKDGWTCLHKAVKSGNMEFVEFILGE 319
Cdd:PHA02875  113 KKLDIMKLLIAR---------------------------------GADPDIP--NTDKFSPLHLAVMMGDIKGIELLIDH 157

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1002307001 320 prlQKLVNMRSSKGKTALHYAIQKCDPKIVAALLDKKIDLTILGSDGNAAA 370
Cdd:PHA02875  158 ---KACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAA 205
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 199-367 5.17e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 46.11  E-value: 5.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 199 LHAAIRNGNPDIAKRIIVERPNLATEENKDGNTPIQLAVRWGKIDMLRVLLKHDRSQGYvINRKNGYPLLLSAAHRGHva 278
Cdd:PHA02874    5 LRMCIYSGDIEAIEKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINH-INTKIPHPLLTAIKIGAH-- 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 279 varEIIKYCPDapyckkDGWTCLHKAVKSGNMEFVEFILgEPRLQklVNMRSSKGKTALHYAIQKCDPKIVAALLDKKID 358
Cdd:PHA02874   82 ---DIIKLLID------NGVDTSILPIPCIEKDMIKTIL-DCGID--VNIKDAELKTFLHYAIKKGDLESIKMLFEYGAD 149


                  ....*....
gi 1002307001 359 LTILGSDGN 367
Cdd:PHA02874  150 VNIEDDNGC 158
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 267-358 6.51e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 45.77  E-value: 6.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 267 LLLSAAHRGHVAVAREIIKyCPDAPYCKKD--GWTCLHKAVKSGNMEFVEFILGEPRlqKLVN--MRSS--KGKTALHYA 340
Cdd:cd22192    20 PLLLAAKENDVQAIKKLLK-CPSCDLFQRGalGETALHVAALYDNLEAAVVLMEAAP--ELVNepMTSDlyQGETALHIA 96

                          90
                  ....*....|....*...
gi 1002307001 341 IQKCDPKIVAALLDKKID 358
Cdd:cd22192    97 VVNQNLNLVRELIARGAD 114
Ank_4 pfam13637
Ankyrin repeats (many copies);
297-353 8.20e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.34  E-value: 8.20e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1002307001 297 GWTCLHKAVKSGNMEFVEFILGEPrlqKLVNMRSSKGKTALHYAIQKCDPKIVAALL 353
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKG---ADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
195-249 1.99e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.57  E-value: 1.99e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1002307001 195 GYNALHAAIRNGNPDIAKRIIvERPNLATEENKDGNTPIQLAVRWGKIDMLRVLL 249
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLL-EKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
190-236 3.69e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.87  E-value: 3.69e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1002307001 190 HSGTYGYNALHAAIRNGNPDIAKRIIVERPNLaTEENKDGNTPIQLA 236
Cdd:pfam13857  11 RLDGEGYTPLHVAAKYGALEIVRVLLAYGVDL-NLKDEEGLTALDLA 56
Ank_2 pfam12796
Ankyrin repeats (3 copies);
15-109 7.71e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 38.94  E-value: 7.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001  15 LLEAAISGDTRSMKMKYMDSHDPTILlgkNPQGNTCLHISSMCGHLEFCKDVLslpqdptvkKKLLTTVNVMNETPLLTA 94
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQ---DKNGRTALHLAAKNGHLEIVKLLL---------EHADVNLKDNGRTALHYA 68

                          90
                  ....*....|....*
gi 1002307001  95 ITSGHVTLAAFLLKY 109
Cdd:pfam12796  69 ARSGHLEIVKLLLEK 83
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 176-356 2.80e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 40.77  E-value: 2.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 176 TDIFEKllgidgsshsGTYGYNALHAAIRNGNPDIAKRIIVERPNLA----TEENKDGNTPIQLAVRWGKIDMLRVLLKH 251
Cdd:cd22192    42 CDLFQR----------GALGETALHVAALYDNLEAAVVLMEAAPELVnepmTSDLYQGETALHIAVVNQNLNLVRELIAR 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 252 D------RSQG--YVINRKN----GYPLLLSAAHRGHVAVAREIIKYCPDAPYCKKDGWTCLHKAVKSGNMEFV----EF 315
Cdd:cd22192   112 GadvvspRATGtfFRPGPKNliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFAcqmyDL 191

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1002307001 316 IL---GEPRLQKLVNMRSSKGKTALHYAIQKCDPKIVAALLDKK 356
Cdd:cd22192   192 ILsydKEDDLQPLDLVPNNQGLTPFKLAAKEGNIVMFQHLVQKR 235
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 130-279 2.87e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.43  E-value: 2.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 130 LHHA-ICNGHKDLALELIAtqpaLSKDVNK---YGESPMYIAlMMRDSKFtdIFEKLL--GIDGSSHSGTYGyNALHAAI 203
Cdd:PHA02876  345 LHQAsTLDRNKDIVITLLE----LGANVNArdyCDKTPIHYA-AVRNNVV--IINTLLdyGADIEALSQKIG-TALHFAL 416

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002307001 204 RNGNPDIAKRIIVERPNLATEENKDGNTPIQLAVRWG-KIDMLRVLLKHDRSQGyVINRKNGYPLLLSAAHRGHVAV 279
Cdd:PHA02876  417 CGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVN-AINIQNQYPLLIALEYHGIVNI 492
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 14-112 5.26e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 39.88  E-value: 5.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001  14 ELLEAAISGDTRSMKMKYMDSHDPTillGKNPQGNTCLHISSMCGHLEFCKDVLSLPQDPTVKKKllttvnvMNETPLLT 93
Cdd:PTZ00322   85 ELCQLAASGDAVGARILLTGGADPN---CRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDK-------DGKTPLEL 154

                          90
                  ....*....|....*....
gi 1002307001  94 AITSGHVTLAAFLLKYCHE 112
Cdd:PTZ00322  155 AEENGFREVVQLLSRHSQC 173
Ank_4 pfam13637
Ankyrin repeats (many copies);
229-281 7.03e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 34.94  E-value: 7.03e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1002307001 229 GNTPIQLAVRWGKIDMLRVLLKHdrsqGYVINR--KNGYPLLLSAAHRGHVAVAR 281
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEK----GADINAvdGNGETALHFAASNGNVEVLK 51
PHA03095 PHA03095
ankyrin-like protein; Provisional
 161-369 7.56e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 39.24  E-value: 7.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 161 ESPMYIALMMRDSKFTDIFEKLLGIDGS-SHSGTYGYNALHAAIRNGNPDIAK--RIIVE---RPNLATeenKDGNTPIQ 234
Cdd:PHA03095   12 EAALYDYLLNASNVTVEEVRRLLAAGADvNFRGEYGKTPLHLYLHYSSEKVKDivRLLLEagaDVNAPE---RCGFTPLH 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 235 LAVRWG-KIDMLRVLLKHdrsqGYVINRKNGYPL-LLSAAHRG---HVAVAREIIKYCPDAPYCKKDGWTCLHKAVKSGN 309
Cdd:PHA03095   89 LYLYNAtTLDVIKLLIKA----GADVNAKDKVGRtPLHVYLSGfniNPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRN 164

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1002307001 310 --MEFVEFIlgeprLQKLVNMRSSK--GKTALHYAIQ--KCDPKIVAALLDKKIDLTILGSDGNAA 369
Cdd:PHA03095  165 anVELLRLL-----IDAGADVYAVDdrFRSLLHHHLQsfKPRARIVRELIRAGCDPAATDMLGNTP 225
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 83-249 7.62e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 39.47  E-value: 7.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001  83 VNVMNETPLLTAITSGHVTLAAFLLKycheQGFSEVIlkQDKHKCNALHHAICNGHKDLALELIATQPALS-KDVNkyGE 161
Cdd:PLN03192  521 DDPNMASNLLTVASTGNAALLEELLK----AKLDPDI--GDSKGRTPLHIAASKGYEDCVLVLLKHACNVHiRDAN--GN 592

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 162 SPMYIALMmrdSKFTDIFEKLLGIDGSSHSGTYGyNALHAAIRNGNPDIAKRIIVERPNLATeENKDGNTPIQLAVRWGK 241
Cdd:PLN03192  593 TALWNAIS---AKHHKIFRILYHFASISDPHAAG-DLLCTAAKRNDLTAMKELLKQGLNVDS-EDHQGATALQVAMAEDH 667


                  ....*...
gi 1002307001 242 IDMLRVLL 249
Cdd:PLN03192  668 VDMVRLLI 675
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 164-367 8.11e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 38.88  E-value: 8.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 164 MYIALMmRDSKFTDIFEKllGIDGSSHSGTYGY----NALHAAIRNGNPDIAKRIIVERPNLATEENKDgNTPIQLAVRW 239
Cdd:PHA03100    3 SYIVLT-KSRIIKVKNIK--YIIMEDDLNDYSYkkpvLPLYLAKEARNIDVVKILLDNGADINSSTKNN-STPLHYLSNI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002307001 240 GKI-----DMLRVLLKHDrSQGYVINRKNGYPLLLSAA-HRGHVAVAREIIKYCPDAPYCKKDGWTCLHKAVKSGNMEF- 312
Cdd:PHA03100   79 KYNltdvkEIVKLLLEYG-ANVNAPDNNGITPLLYAISkKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLk 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1002307001 313 -VEFIL-------GEPRLQKL------VNMRSSKGKTALHYAIQKCDPKIVAALLDKKIDLTILGSDGN 367
Cdd:PHA03100  158 iLKLLIdkgvdinAKNRVNYLlsygvpINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGD 226
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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