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Conserved domains on  [gi|1002232652|ref|XP_015617826|]
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protein TPR1 isoform X2 [Oryza sativa Japonica Group]

Protein Classification

LisH and CTLH domain-containing protein( domain architecture ID 13922873)

protein containing domains LisH, CTLH, and WD40

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 324-635 4.57e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 129.76  E-value: 4.57e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  324 SSVTSMDFHPTRHtLLLVGSTNGEItlwevgmrerlfskpfKIWDIQACSPQFQSVAKesSISINRVTWSPDGDLIGVAF 403
Cdd:cd00200     10 GGVTCVAFSPDGK-LLATGSGDGTI----------------KVWDLETGELLRTLKGH--TGPVRDVAASADGTYLASGS 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  404 AKHLIHLHAYQQPNETRqvlEIDAHSGAVNDIAFSrPNKQLcVVTCGDDRLIKVWDMH-GQKLFSFEGHEAPVYSICPHH 482
Cdd:cd00200     71 SDKTIRLWDLETGECVR---TLTGHTSYVSSVAFS-PDGRI-LSSSSRDKTIKVWDVEtGKCLTTLRGHTDWVNSVAFSP 145

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  483 KEsiQFIFSTSLDGKIKAWLYDHMGSRVDYDAPGKWCTTMLYSADGTRLFSCGTskDGDSYLveWNESEGSIKRTYSGfr 562
Cdd:cd00200    146 DG--TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS--DGTIKL--WDLSTGKCLGTLRG-- 217

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002232652  563 kKSAGVGVVQFDTAQNHILAAGEDNQIKFWDVDNTTMLSSteadggLPGLP----RLRFNKEGNLLAVTTVDNGFKI 635
Cdd:cd00200    218 -HENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT------LSGHTnsvtSLAWSPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
393-930 8.92e-22

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.22  E-value: 8.92e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  393 SPDGDLIGVAFAKHLIHLHAYQQPNETRQVLeidAHSGAVNDIAFSRPNKQLcVVTCGDDRLIKVWDMHGQKLFSFEGHE 472
Cdd:COG2319      3 SADGAALAAASADLALALLAAALGALLLLLL---GLAAAVASLAASPDGARL-AAGAGDLTLLLLDAAAGALLATLLGHT 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  473 APVYSIcpHHKESIQFIFSTSLDGKIKAWLYDHMGSRVDYDAPGKWCTTMLYSADGTRLFSCGtskdGDSYLVEWNESEG 552
Cdd:COG2319     79 AAVLSV--AFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGS----ADGTVRLWDLATG 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  553 SIKRTYSGfrkKSAGVGVVQFDTAQNHILAAGEDNQIKFWDVDNTTMLSSTEADGGlpGLPRLRFNKEGNLLAVTTVDNG 632
Cdd:COG2319    153 KLLRTLTG---HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG--AVRSVAFSPDGKLLASGSADGT 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  633 FKILaNADGLRTLRAFGnrpfeafrsqyeassmkvsgapvvagispnigrmdhidrnspakpspimnGGDPASRSIDIkp 712
Cdd:COG2319    228 VRLW-DLATGKLLRTLT--------------------------------------------------GHSGSVRSVAF-- 254

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  713 riseerpdkakpwelmevlnaqqcrvatmpeTPDQaskvvRLLYTNSGVGLLalgsnaiqRLWkwarndqNPSGKATANV 792
Cdd:COG2319    255 -------------------------------SPDG-----RLLASGSADGTV--------RLW-------DLATGELLRT 283

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  793 VPQHwqpnsglvmqndtadtnpEDAVPCIALSKNDSYVMSACG-GKVSLFNMMTFKVMTTFMPPPPASTFLAFHPqDNNI 871
Cdd:COG2319    284 LTGH------------------SGGVNSVAFSPDGKLLASGSDdGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKT 344

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1002232652  872 IAIGMEDSTIHIYNVRVDEVKTRLKGHQRRITGLAFSNNLQILVSSGADAQLCVWATDT 930
Cdd:COG2319    345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
814-1072 4.36e-20

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.21  E-value: 4.36e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  814 PEDAVPCIALSKNDSYVMSACG-GKVSLFNMMTFKVMTTFMPPPPASTFLAFHPqDNNIIAIGMEDSTIHIYNVRVDEVK 892
Cdd:COG2319    161 HSGAVTSVAFSPDGKLLASGSDdGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLL 239

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  893 TRLKGHQRRITGLAFSNNLQILVSSGADAQLCVWATDTWEKKKSVaiqmpagKTPSGDTW-VQFNSDwSRLLVV--HETQ 969
Cdd:COG2319    240 RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTL-------TGHSGGVNsVAFSPD-GKLLASgsDDGT 311

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  970 LAIYDASKMERIYQWipqDALSAPISHASYSRNSQLVFAAFTDGNIGIFDVENLRLRCRIAPPaylsSAAINSnpsvypl 1049
Cdd:COG2319    312 VRLWDLATGKLLRTL---TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGH----TGAVTS------- 377

                          250       260
                   ....*....|....*....|...
gi 1002232652 1050 vVAAHPqESNQFAVGLSDGSVKV 1072
Cdd:COG2319    378 -VAFSP-DGRTLASGSADGTVRL 398
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 34-92 3.34e-15

C-terminal to LisH motif; Alpha-helical motif of unknown function.


:

Pssm-ID: 128914  Cd Length: 58  Bit Score: 70.68  E-value: 3.34e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1002232652    34 FFFNMKYFEEKVHAGEWDEVEKYLSGFTKVDDNRYSmKIFFEIRKQKYLEALDRHDRAK 92
Cdd:smart00668    1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERNS-KLEFELRKQKFLELVRQGKLEE 58
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
203-305 8.34e-06

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK14951:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 618  Bit Score: 50.10  E-value: 8.34e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  203 TCTPPNGARASPVSVPLAAVPKAGGTYPPLTAHTPFQPPPA---GPSLAGWMANAAAATSSVPSAVVAASSLPVPPNQES 279
Cdd:PRK14951   380 TPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAappAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQAAPET 459

                           90       100
                   ....*....|....*....|....*.
gi 1002232652  280 EQLMKRLRPSGHGVDEATYPAPIPQP 305
Cdd:PRK14951   460 VAIPVRVAPEPAVASAAPAPAAAPAA 485
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 4-34 9.19e-06

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


:

Pssm-ID: 128913  Cd Length: 34  Bit Score: 43.19  E-value: 9.19e-06
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1002232652     4 LSRELVFLILQFLDEEKFKETVHKLEQESGF 34
Cdd:smart00667    2 SRSELNRLILEYLLRNGYEETAETLQKESGL 32
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 324-635 4.57e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 129.76  E-value: 4.57e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  324 SSVTSMDFHPTRHtLLLVGSTNGEItlwevgmrerlfskpfKIWDIQACSPQFQSVAKesSISINRVTWSPDGDLIGVAF 403
Cdd:cd00200     10 GGVTCVAFSPDGK-LLATGSGDGTI----------------KVWDLETGELLRTLKGH--TGPVRDVAASADGTYLASGS 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  404 AKHLIHLHAYQQPNETRqvlEIDAHSGAVNDIAFSrPNKQLcVVTCGDDRLIKVWDMH-GQKLFSFEGHEAPVYSICPHH 482
Cdd:cd00200     71 SDKTIRLWDLETGECVR---TLTGHTSYVSSVAFS-PDGRI-LSSSSRDKTIKVWDVEtGKCLTTLRGHTDWVNSVAFSP 145

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  483 KEsiQFIFSTSLDGKIKAWLYDHMGSRVDYDAPGKWCTTMLYSADGTRLFSCGTskDGDSYLveWNESEGSIKRTYSGfr 562
Cdd:cd00200    146 DG--TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS--DGTIKL--WDLSTGKCLGTLRG-- 217

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002232652  563 kKSAGVGVVQFDTAQNHILAAGEDNQIKFWDVDNTTMLSSteadggLPGLP----RLRFNKEGNLLAVTTVDNGFKI 635
Cdd:cd00200    218 -HENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT------LSGHTnsvtSLAWSPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
210-635 8.39e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 123.10  E-value: 8.39e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  210 ARASPVSVPLAAVPKAGGTYPPLTAHTPFQPPPAGPSLAGWMANAAAATSSVPSAVVAASSLPVPPNQESEQLMKRLRPS 289
Cdd:COG2319     10 AAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPD 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  290 GHGVDEATYPAPIPqpLWSVEDlPRTVACTLSQGSSVTSMDFHPTRHTLLlVGSTNGEItlwevgmrerlfskpfKIWDI 369
Cdd:COG2319     90 GRLLASASADGTVR--LWDLAT-GLLLRTLTGHTGAVRSVAFSPDGKTLA-SGSADGTV----------------RLWDL 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  370 QacSPQFQSVAKESSISINRVTWSPDGDLIGVAFAKHLIHLHayqQPNETRQVLEIDAHSGAVNDIAFSRPNKQLcvVTC 449
Cdd:COG2319    150 A--TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW---DLATGKLLRTLTGHTGAVRSVAFSPDGKLL--ASG 222

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  450 GDDRLIKVWDMH-GQKLFSFEGHEAPVYSICPHHKEsiQFIFSTSLDGKIKAWLYDHMGSRVDYDAPGKWCTTMLYSADG 528
Cdd:COG2319    223 SADGTVRLWDLAtGKLLRTLTGHSGSVRSVAFSPDG--RLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDG 300

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  529 TRLFScgTSKDGDSYLveWNESEGSIKRTYSGfrkKSAGVGVVQFDTAQNHILAAGEDNQIKFWDVDNTTMLSSTEADGG 608
Cdd:COG2319    301 KLLAS--GSDDGTVRL--WDLATGKLLRTLTG---HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTG 373

                          410       420
                   ....*....|....*....|....*..
gi 1002232652  609 lpGLPRLRFNKEGNLLAVTTVDNGFKI 635
Cdd:COG2319    374 --AVTSVAFSPDGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
393-930 8.92e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.22  E-value: 8.92e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  393 SPDGDLIGVAFAKHLIHLHAYQQPNETRQVLeidAHSGAVNDIAFSRPNKQLcVVTCGDDRLIKVWDMHGQKLFSFEGHE 472
Cdd:COG2319      3 SADGAALAAASADLALALLAAALGALLLLLL---GLAAAVASLAASPDGARL-AAGAGDLTLLLLDAAAGALLATLLGHT 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  473 APVYSIcpHHKESIQFIFSTSLDGKIKAWLYDHMGSRVDYDAPGKWCTTMLYSADGTRLFSCGtskdGDSYLVEWNESEG 552
Cdd:COG2319     79 AAVLSV--AFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGS----ADGTVRLWDLATG 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  553 SIKRTYSGfrkKSAGVGVVQFDTAQNHILAAGEDNQIKFWDVDNTTMLSSTEADGGlpGLPRLRFNKEGNLLAVTTVDNG 632
Cdd:COG2319    153 KLLRTLTG---HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG--AVRSVAFSPDGKLLASGSADGT 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  633 FKILaNADGLRTLRAFGnrpfeafrsqyeassmkvsgapvvagispnigrmdhidrnspakpspimnGGDPASRSIDIkp 712
Cdd:COG2319    228 VRLW-DLATGKLLRTLT--------------------------------------------------GHSGSVRSVAF-- 254

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  713 riseerpdkakpwelmevlnaqqcrvatmpeTPDQaskvvRLLYTNSGVGLLalgsnaiqRLWkwarndqNPSGKATANV 792
Cdd:COG2319    255 -------------------------------SPDG-----RLLASGSADGTV--------RLW-------DLATGELLRT 283

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  793 VPQHwqpnsglvmqndtadtnpEDAVPCIALSKNDSYVMSACG-GKVSLFNMMTFKVMTTFMPPPPASTFLAFHPqDNNI 871
Cdd:COG2319    284 LTGH------------------SGGVNSVAFSPDGKLLASGSDdGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKT 344

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1002232652  872 IAIGMEDSTIHIYNVRVDEVKTRLKGHQRRITGLAFSNNLQILVSSGADAQLCVWATDT 930
Cdd:COG2319    345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
814-1072 4.36e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.21  E-value: 4.36e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  814 PEDAVPCIALSKNDSYVMSACG-GKVSLFNMMTFKVMTTFMPPPPASTFLAFHPqDNNIIAIGMEDSTIHIYNVRVDEVK 892
Cdd:COG2319    161 HSGAVTSVAFSPDGKLLASGSDdGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLL 239

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  893 TRLKGHQRRITGLAFSNNLQILVSSGADAQLCVWATDTWEKKKSVaiqmpagKTPSGDTW-VQFNSDwSRLLVV--HETQ 969
Cdd:COG2319    240 RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTL-------TGHSGGVNsVAFSPD-GKLLASgsDDGT 311

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  970 LAIYDASKMERIYQWipqDALSAPISHASYSRNSQLVFAAFTDGNIGIFDVENLRLRCRIAPPaylsSAAINSnpsvypl 1049
Cdd:COG2319    312 VRLWDLATGKLLRTL---TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGH----TGAVTS------- 377

                          250       260
                   ....*....|....*....|...
gi 1002232652 1050 vVAAHPqESNQFAVGLSDGSVKV 1072
Cdd:COG2319    378 -VAFSP-DGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 815-1072 1.92e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.23  E-value: 1.92e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  815 EDAVPCIALSKNDSYVmSACG--GKVSLFNMMTFKVMTTFMPPPPASTFLAFHPqDNNIIAIGMEDSTIHIYNVRVDEVK 892
Cdd:cd00200     93 TSYVSSVAFSPDGRIL-SSSSrdKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCV 170

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  893 TRLKGHQRRITGLAFSNNLQILVSSGADAQLCVWATDTWekkksvaiqmpagktpsgdtwvqfnsDWSRLLVVHEtqlai 972
Cdd:cd00200    171 ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG--------------------------KCLGTLRGHE----- 219

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  973 ydaskmeriyqwipqdalsAPISHASYSRNSQLVFAAFTDGNIGIFDVENLRLRCRIAppayLSSAAINSnpsvyplvVA 1052
Cdd:cd00200    220 -------------------NGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLS----GHTNSVTS--------LA 268

                          250       260
                   ....*....|....*....|
gi 1002232652 1053 AHPqESNQFAVGLSDGSVKV 1072
Cdd:cd00200    269 WSP-DGKRLASGSADGTIRI 287
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 34-92 3.34e-15

C-terminal to LisH motif; Alpha-helical motif of unknown function.


Pssm-ID: 128914  Cd Length: 58  Bit Score: 70.68  E-value: 3.34e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1002232652    34 FFFNMKYFEEKVHAGEWDEVEKYLSGFTKVDDNRYSmKIFFEIRKQKYLEALDRHDRAK 92
Cdd:smart00668    1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERNS-KLEFELRKQKFLELVRQGKLEE 58
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 420-459 7.49e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 7.49e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1002232652   420 RQVLEIDAHSGAVNDIAFSRPNKQLcvVTCGDDRLIKVWD 459
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYL--ASGSDDGTIKLWD 40
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 203-305 8.34e-06

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 50.10  E-value: 8.34e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  203 TCTPPNGARASPVSVPLAAVPKAGGTYPPLTAHTPFQPPPA---GPSLAGWMANAAAATSSVPSAVVAASSLPVPPNQES 279
Cdd:PRK14951   380 TPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAappAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQAAPET 459

                           90       100
                   ....*....|....*....|....*.
gi 1002232652  280 EQLMKRLRPSGHGVDEATYPAPIPQP 305
Cdd:PRK14951   460 VAIPVRVAPEPAVASAAPAPAAAPAA 485
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 4-34 9.19e-06

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 43.19  E-value: 9.19e-06
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1002232652     4 LSRELVFLILQFLDEEKFKETVHKLEQESGF 34
Cdd:smart00667    2 SRSELNRLILEYLLRNGYEETAETLQKESGL 32
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 890-926 1.40e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 1.40e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1002232652   890 EVKTRLKGHQRRITGLAFSNNLQILVSSGADAQLCVW 926
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PTZ00420 PTZ00420
coronin; Provisional
 862-942 1.63e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.79  E-value: 1.63e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  862 LAFHPQDNNIIAIGMEDSTIHIYNVR-----VDEVKTR---LKGHQRRITGLAFSN-NLQILVSSGADAQLCVWatDTWE 932
Cdd:PTZ00420    80 LQFNPCFSEILASGSEDLTIRVWEIPhndesVKEIKDPqciLKGHKKKISIIDWNPmNYYIMCSSGFDSFVNIW--DIEN 157

                           90
                   ....*....|
gi 1002232652  933 KKKSVAIQMP 942
Cdd:PTZ00420   158 EKRAFQINMP 167
WD40 pfam00400
WD domain, G-beta repeat;
420-459 2.62e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 2.62e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1002232652  420 RQVLEIDAHSGAVNDIAFSrPNKQLcVVTCGDDRLIKVWD 459
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFS-PDGKL-LASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
890-926 1.83e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 1.83e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1002232652  890 EVKTRLKGHQRRITGLAFSNNLQILVSSGADAQLCVW 926
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
LisH_TPL pfam17814
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ...
 5-33 2.52e-04

LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.


Pssm-ID: 375350  Cd Length: 30  Bit Score: 39.30  E-value: 2.52e-04
                           10        20
                   ....*....|....*....|....*....
gi 1002232652    5 SRELVFLILQFLDEEKFKETVHKLEQESG 33
Cdd:pfam17814    1 SQDVVRLILQFLKENGLHRTLQALQTESG 29
PTZ00421 PTZ00421
coronin; Provisional
 862-1025 1.53e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.57  E-value: 1.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  862 LAFHPQDNNIIAIGMEDSTIHIYNVRVDEVKTRLKGHQRRITGLAFsnNLQ----------------------ILVSSGA 919
Cdd:PTZ00421   131 VSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEW--NLDgsllcttskdkklniidprdgtIVSSVEA 208

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  920 DA----QLCVWAtdtweKKKSVAIQmpagktpsgdtwVQFNSDWSRllvvhetQLAIYDASKMERIYQWIPQDALSAPIS 995
Cdd:PTZ00421   209 HAsaksQRCLWA-----KRKDLIIT------------LGCSKSQQR-------QIMLWDTRKMASPYSTVDLDQSSALFI 264

                          170       180       190
                   ....*....|....*....|....*....|
gi 1002232652  996 HASYSRNSQLVFAAFTDGNIGIFDVENLRL 1025
Cdd:PTZ00421   265 PFFDEDTNLLYIGSKGEGNIRCFELMNERL 294
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 324-635 4.57e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 129.76  E-value: 4.57e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  324 SSVTSMDFHPTRHtLLLVGSTNGEItlwevgmrerlfskpfKIWDIQACSPQFQSVAKesSISINRVTWSPDGDLIGVAF 403
Cdd:cd00200     10 GGVTCVAFSPDGK-LLATGSGDGTI----------------KVWDLETGELLRTLKGH--TGPVRDVAASADGTYLASGS 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  404 AKHLIHLHAYQQPNETRqvlEIDAHSGAVNDIAFSrPNKQLcVVTCGDDRLIKVWDMH-GQKLFSFEGHEAPVYSICPHH 482
Cdd:cd00200     71 SDKTIRLWDLETGECVR---TLTGHTSYVSSVAFS-PDGRI-LSSSSRDKTIKVWDVEtGKCLTTLRGHTDWVNSVAFSP 145

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  483 KEsiQFIFSTSLDGKIKAWLYDHMGSRVDYDAPGKWCTTMLYSADGTRLFSCGTskDGDSYLveWNESEGSIKRTYSGfr 562
Cdd:cd00200    146 DG--TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS--DGTIKL--WDLSTGKCLGTLRG-- 217

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002232652  563 kKSAGVGVVQFDTAQNHILAAGEDNQIKFWDVDNTTMLSSteadggLPGLP----RLRFNKEGNLLAVTTVDNGFKI 635
Cdd:cd00200    218 -HENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT------LSGHTnsvtSLAWSPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
210-635 8.39e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 123.10  E-value: 8.39e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  210 ARASPVSVPLAAVPKAGGTYPPLTAHTPFQPPPAGPSLAGWMANAAAATSSVPSAVVAASSLPVPPNQESEQLMKRLRPS 289
Cdd:COG2319     10 AAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPD 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  290 GHGVDEATYPAPIPqpLWSVEDlPRTVACTLSQGSSVTSMDFHPTRHTLLlVGSTNGEItlwevgmrerlfskpfKIWDI 369
Cdd:COG2319     90 GRLLASASADGTVR--LWDLAT-GLLLRTLTGHTGAVRSVAFSPDGKTLA-SGSADGTV----------------RLWDL 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  370 QacSPQFQSVAKESSISINRVTWSPDGDLIGVAFAKHLIHLHayqQPNETRQVLEIDAHSGAVNDIAFSRPNKQLcvVTC 449
Cdd:COG2319    150 A--TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW---DLATGKLLRTLTGHTGAVRSVAFSPDGKLL--ASG 222

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  450 GDDRLIKVWDMH-GQKLFSFEGHEAPVYSICPHHKEsiQFIFSTSLDGKIKAWLYDHMGSRVDYDAPGKWCTTMLYSADG 528
Cdd:COG2319    223 SADGTVRLWDLAtGKLLRTLTGHSGSVRSVAFSPDG--RLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDG 300

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  529 TRLFScgTSKDGDSYLveWNESEGSIKRTYSGfrkKSAGVGVVQFDTAQNHILAAGEDNQIKFWDVDNTTMLSSTEADGG 608
Cdd:COG2319    301 KLLAS--GSDDGTVRL--WDLATGKLLRTLTG---HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTG 373

                          410       420
                   ....*....|....*....|....*..
gi 1002232652  609 lpGLPRLRFNKEGNLLAVTTVDNGFKI 635
Cdd:COG2319    374 --AVTSVAFSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 324-593 4.61e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.49  E-value: 4.61e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  324 SSVTSMDFHPTRHtLLLVGSTNGEItlwevgmrerlfskpfKIWDIqacspqfqsvakessisinrvtwspdgdligvaf 403
Cdd:cd00200     94 SYVSSVAFSPDGR-ILSSSSRDKTI----------------KVWDV---------------------------------- 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  404 akhlihlhayqqpNETRQVLEIDAHSGAVNDIAFSrPNKQLcVVTCGDDRLIKVWDMHGQKLF-SFEGHEAPVYSICPHH 482
Cdd:cd00200    123 -------------ETGKCLTTLRGHTDWVNSVAFS-PDGTF-VASSSQDGTIKLWDLRTGKCVaTLTGHTGEVNSVAFSP 187

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  483 KESiqFIFSTSLDGKIKawLYDHMGSRVDYDAPG--KWCTTMLYSADGtRLFSCGtskDGDSYLVEWNESEGSIKRTYSG 560
Cdd:cd00200    188 DGE--KLLSSSSDGTIK--LWDLSTGKCLGTLRGheNGVNSVAFSPDG-YLLASG---SEDGTIRVWDLRTGECVQTLSG 259

                          250       260       270
                   ....*....|....*....|....*....|...
gi 1002232652  561 FrkkSAGVGVVQFDTAQNHILAAGEDNQIKFWD 593
Cdd:cd00200    260 H---TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
393-930 8.92e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.22  E-value: 8.92e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  393 SPDGDLIGVAFAKHLIHLHAYQQPNETRQVLeidAHSGAVNDIAFSRPNKQLcVVTCGDDRLIKVWDMHGQKLFSFEGHE 472
Cdd:COG2319      3 SADGAALAAASADLALALLAAALGALLLLLL---GLAAAVASLAASPDGARL-AAGAGDLTLLLLDAAAGALLATLLGHT 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  473 APVYSIcpHHKESIQFIFSTSLDGKIKAWLYDHMGSRVDYDAPGKWCTTMLYSADGTRLFSCGtskdGDSYLVEWNESEG 552
Cdd:COG2319     79 AAVLSV--AFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGS----ADGTVRLWDLATG 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  553 SIKRTYSGfrkKSAGVGVVQFDTAQNHILAAGEDNQIKFWDVDNTTMLSSTEADGGlpGLPRLRFNKEGNLLAVTTVDNG 632
Cdd:COG2319    153 KLLRTLTG---HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG--AVRSVAFSPDGKLLASGSADGT 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  633 FKILaNADGLRTLRAFGnrpfeafrsqyeassmkvsgapvvagispnigrmdhidrnspakpspimnGGDPASRSIDIkp 712
Cdd:COG2319    228 VRLW-DLATGKLLRTLT--------------------------------------------------GHSGSVRSVAF-- 254

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  713 riseerpdkakpwelmevlnaqqcrvatmpeTPDQaskvvRLLYTNSGVGLLalgsnaiqRLWkwarndqNPSGKATANV 792
Cdd:COG2319    255 -------------------------------SPDG-----RLLASGSADGTV--------RLW-------DLATGELLRT 283

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  793 VPQHwqpnsglvmqndtadtnpEDAVPCIALSKNDSYVMSACG-GKVSLFNMMTFKVMTTFMPPPPASTFLAFHPqDNNI 871
Cdd:COG2319    284 LTGH------------------SGGVNSVAFSPDGKLLASGSDdGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKT 344

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1002232652  872 IAIGMEDSTIHIYNVRVDEVKTRLKGHQRRITGLAFSNNLQILVSSGADAQLCVWATDT 930
Cdd:COG2319    345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
814-1072 4.36e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.21  E-value: 4.36e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  814 PEDAVPCIALSKNDSYVMSACG-GKVSLFNMMTFKVMTTFMPPPPASTFLAFHPqDNNIIAIGMEDSTIHIYNVRVDEVK 892
Cdd:COG2319    161 HSGAVTSVAFSPDGKLLASGSDdGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLL 239

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  893 TRLKGHQRRITGLAFSNNLQILVSSGADAQLCVWATDTWEKKKSVaiqmpagKTPSGDTW-VQFNSDwSRLLVV--HETQ 969
Cdd:COG2319    240 RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTL-------TGHSGGVNsVAFSPD-GKLLASgsDDGT 311

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  970 LAIYDASKMERIYQWipqDALSAPISHASYSRNSQLVFAAFTDGNIGIFDVENLRLRCRIAPPaylsSAAINSnpsvypl 1049
Cdd:COG2319    312 VRLWDLATGKLLRTL---TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGH----TGAVTS------- 377

                          250       260
                   ....*....|....*....|...
gi 1002232652 1050 vVAAHPqESNQFAVGLSDGSVKV 1072
Cdd:COG2319    378 -VAFSP-DGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 424-651 9.76e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.08  E-value: 9.76e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  424 EIDAHSGAVNDIAFSRPNKQLC----------------------------------------VVTCGDDRLIKVWDMH-G 462
Cdd:cd00200      4 TLKGHTGGVTCVAFSPDGKLLAtgsgdgtikvwdletgellrtlkghtgpvrdvaasadgtyLASGSSDKTIRLWDLEtG 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  463 QKLFSFEGHEAPVYSICPHHKESIqfIFSTSLDGKIKAW----------LYDHMGsrvdydapgkWCTTMLYSADGTRLF 532
Cdd:cd00200     84 ECVRTLTGHTSYVSSVAFSPDGRI--LSSSSRDKTIKVWdvetgkclttLRGHTD----------WVNSVAFSPDGTFVA 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  533 SCgtSKDGDSYLveWNESEGSIKRTYSGFrkkSAGVGVVQFDTAQNHILAAGEDNQIKFWDVDNTTMLSSTEADGGlpGL 612
Cdd:cd00200    152 SS--SQDGTIKL--WDLRTGKCVATLTGH---TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN--GV 222

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 1002232652  613 PRLRFNKEGNLLAVTTVDNGFKI--LANADGLRTLRAFGNR 651
Cdd:cd00200    223 NSVAFSPDGYLLASGSEDGTIRVwdLRTGECVQTLSGHTNS 263
WD40 COG2319
WD40 repeat [General function prediction only];
812-1022 1.11e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.89  E-value: 1.11e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  812 TNPEDAVPCIALSKNDSYVMSACG-GKVSLFNMMTFKVMTTFMPPPPASTFLAFHPqDNNIIAIGMEDSTIHIYNVRVDE 890
Cdd:COG2319    201 TGHTGAVRSVAFSPDGKLLASGSAdGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGE 279

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  891 VKTRLKGHQRRITGLAFSNNLQILVSSGADAQLCVWATDTWEkkksvaiqmpAGKTPSGDTW----VQFNSDwSRLLVV- 965
Cdd:COG2319    280 LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGK----------LLRTLTGHTGavrsVAFSPD-GKTLASg 348

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1002232652  966 -HETQLAIYDASKMERIYQWipqDALSAPISHASYSRNSQLVFAAFTDGNIGIFDVEN 1022
Cdd:COG2319    349 sDDGTVRLWDLATGELLRTL---TGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
744-1072 9.23e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.81  E-value: 9.23e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  744 TPDQASKVVRLLYTNSGVGLLALGSNAIQRLWKWARNDQNPSGKATANVVPQHWQPNSGLVmqndTADTNPEDAVPCIAL 823
Cdd:COG2319     11 AASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALL----ATLLGHTAAVLSVAF 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  824 SKNDSYVMSACG-GKVSLFNMMTFKVMTTFMPPPPASTFLAFHPqDNNIIAIGMEDSTIHIYNVRVDEVKTRLKGHQRRI 902
Cdd:COG2319     87 SPDGRLLASASAdGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAV 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  903 TGLAFSNNLQILVSSGADAQLCVWATDTWEkkksvaiqmpAGKTPSGDTW----VQFNSDwSRLLVV--HETQLAIYDAS 976
Cdd:COG2319    166 TSVAFSPDGKLLASGSDDGTVRLWDLATGK----------LLRTLTGHTGavrsVAFSPD-GKLLASgsADGTVRLWDLA 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  977 KMERIYQWipqDALSAPISHASYSRNSQLVFAAFTDGNIGIFDVENLRLRCRIAPPaylsSAAINSnpsvyplvVAAHPq 1056
Cdd:COG2319    235 TGKLLRTL---TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH----SGGVNS--------VAFSP- 298

                          330
                   ....*....|....*.
gi 1002232652 1057 ESNQFAVGLSDGSVKV 1072
Cdd:COG2319    299 DGKLLASGSDDGTVRL 314
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 815-1072 1.92e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.23  E-value: 1.92e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  815 EDAVPCIALSKNDSYVmSACG--GKVSLFNMMTFKVMTTFMPPPPASTFLAFHPqDNNIIAIGMEDSTIHIYNVRVDEVK 892
Cdd:cd00200     93 TSYVSSVAFSPDGRIL-SSSSrdKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCV 170

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  893 TRLKGHQRRITGLAFSNNLQILVSSGADAQLCVWATDTWekkksvaiqmpagktpsgdtwvqfnsDWSRLLVVHEtqlai 972
Cdd:cd00200    171 ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG--------------------------KCLGTLRGHE----- 219

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  973 ydaskmeriyqwipqdalsAPISHASYSRNSQLVFAAFTDGNIGIFDVENLRLRCRIAppayLSSAAINSnpsvyplvVA 1052
Cdd:cd00200    220 -------------------NGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLS----GHTNSVTS--------LA 268

                          250       260
                   ....*....|....*....|
gi 1002232652 1053 AHPqESNQFAVGLSDGSVKV 1072
Cdd:cd00200    269 WSP-DGKRLASGSADGTIRI 287
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 34-92 3.34e-15

C-terminal to LisH motif; Alpha-helical motif of unknown function.


Pssm-ID: 128914  Cd Length: 58  Bit Score: 70.68  E-value: 3.34e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1002232652    34 FFFNMKYFEEKVHAGEWDEVEKYLSGFTKVDDNRYSmKIFFEIRKQKYLEALDRHDRAK 92
Cdd:smart00668    1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERNS-KLEFELRKQKFLELVRQGKLEE 58
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 895-1085 2.52e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.66  E-value: 2.52e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  895 LKGHQRRITGLAFSNNLQILVSSGADAQLCVWATDTWEKKKSvaiqmPAGKTpSGDTWVQFNSDWSRLLVVHE-TQLAIY 973
Cdd:cd00200      5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRT-----LKGHT-GPVRDVAASADGTYLASGSSdKTIRLW 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  974 DASKMERIYQWIPQdalSAPISHASYSRNSQLVFAAFTDGNIGIFDVENLRLR------------CRIAP-PAYLSSAA- 1039
Cdd:cd00200     79 DLETGECVRTLTGH---TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLttlrghtdwvnsVAFSPdGTFVASSSq 155

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002232652 1040 --------INSNPSVYPLV--------VAAHPqESNQFAVGLSDGSVKVIEPleSEGKWGTT 1085
Cdd:cd00200    156 dgtiklwdLRTGKCVATLTghtgevnsVAFSP-DGEKLLSSSSDGTIKLWDL--STGKCLGT 214
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 420-459 7.49e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 7.49e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1002232652   420 RQVLEIDAHSGAVNDIAFSRPNKQLcvVTCGDDRLIKVWD 459
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYL--ASGSDDGTIKLWD 40
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 203-305 8.34e-06

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 50.10  E-value: 8.34e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  203 TCTPPNGARASPVSVPLAAVPKAGGTYPPLTAHTPFQPPPA---GPSLAGWMANAAAATSSVPSAVVAASSLPVPPNQES 279
Cdd:PRK14951   380 TPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAappAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQAAPET 459

                           90       100
                   ....*....|....*....|....*.
gi 1002232652  280 EQLMKRLRPSGHGVDEATYPAPIPQP 305
Cdd:PRK14951   460 VAIPVRVAPEPAVASAAPAPAAAPAA 485
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 4-34 9.19e-06

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 43.19  E-value: 9.19e-06
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1002232652     4 LSRELVFLILQFLDEEKFKETVHKLEQESGF 34
Cdd:smart00667    2 SRSELNRLILEYLLRNGYEETAETLQKESGL 32
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 890-926 1.40e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 1.40e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1002232652   890 EVKTRLKGHQRRITGLAFSNNLQILVSSGADAQLCVW 926
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PTZ00420 PTZ00420
coronin; Provisional
 862-942 1.63e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.79  E-value: 1.63e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  862 LAFHPQDNNIIAIGMEDSTIHIYNVR-----VDEVKTR---LKGHQRRITGLAFSN-NLQILVSSGADAQLCVWatDTWE 932
Cdd:PTZ00420    80 LQFNPCFSEILASGSEDLTIRVWEIPhndesVKEIKDPqciLKGHKKKISIIDWNPmNYYIMCSSGFDSFVNIW--DIEN 157

                           90
                   ....*....|
gi 1002232652  933 KKKSVAIQMP 942
Cdd:PTZ00420   158 EKRAFQINMP 167
WD40 pfam00400
WD domain, G-beta repeat;
420-459 2.62e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 2.62e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1002232652  420 RQVLEIDAHSGAVNDIAFSrPNKQLcVVTCGDDRLIKVWD 459
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFS-PDGKL-LASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
890-926 1.83e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 1.83e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1002232652  890 EVKTRLKGHQRRITGLAFSNNLQILVSSGADAQLCVW 926
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
462-501 2.48e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 2.48e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1002232652  462 GQKLFSFEGHEAPVYSICPHHKEsiQFIFSTSLDGKIKAW 501
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDG--KLLASGSDDGTVKVW 38
LisH_TPL pfam17814
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ...
 5-33 2.52e-04

LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.


Pssm-ID: 375350  Cd Length: 30  Bit Score: 39.30  E-value: 2.52e-04
                           10        20
                   ....*....|....*....|....*....
gi 1002232652    5 SRELVFLILQFLDEEKFKETVHKLEQESG 33
Cdd:pfam17814    1 SQDVVRLILQFLKENGLHRTLQALQTESG 29
PTZ00421 PTZ00421
coronin; Provisional
 862-1025 1.53e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.57  E-value: 1.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  862 LAFHPQDNNIIAIGMEDSTIHIYNVRVDEVKTRLKGHQRRITGLAFsnNLQ----------------------ILVSSGA 919
Cdd:PTZ00421   131 VSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEW--NLDgsllcttskdkklniidprdgtIVSSVEA 208

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  920 DA----QLCVWAtdtweKKKSVAIQmpagktpsgdtwVQFNSDWSRllvvhetQLAIYDASKMERIYQWIPQDALSAPIS 995
Cdd:PTZ00421   209 HAsaksQRCLWA-----KRKDLIIT------------LGCSKSQQR-------QIMLWDTRKMASPYSTVDLDQSSALFI 264

                          170       180       190
                   ....*....|....*....|....*....|
gi 1002232652  996 HASYSRNSQLVFAAFTDGNIGIFDVENLRL 1025
Cdd:PTZ00421   265 PFFDEDTNLLYIGSKGEGNIRCFELMNERL 294
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 205-305 9.16e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.97  E-value: 9.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002232652  205 TPPNGARASPVSVPLAAVPKAGGTYPPLTAHTPFQPPPAGPSLAGWMANAAAATSSVPSAVVAASSLPVPPNQESEQLMK 284
Cdd:PRK07764   399 PSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTA 478

                           90       100
                   ....*....|....*....|.
gi 1002232652  285 RLRPSGHGVDEATYPAPIPQP 305
Cdd:PRK07764   479 APAPAPPAAPAPAAAPAAPAA 499
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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