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Conserved domains on  [gi|1002313752|ref|XP_015620246|]
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tryptophan--tRNA ligase, cytoplasmic [Oryza sativa Japonica Group]

Protein Classification

tryptophan--tRNA ligase( domain architecture ID 10010810)

tryptophan--tRNA ligase (TrpRS) catalyzes the activation of tryptophan by ATP and transfer to tRNA(Trp), ensuring translation of the genetic code for tryptophan

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02486 PLN02486
aminoacyl-tRNA ligase
 23-404 0e+00

aminoacyl-tRNA ligase


:

Pssm-ID: 178104  Cd Length: 383  Bit Score: 823.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752  23 QVVNPWEVSAGKGG-IDYDKLVDQFGCQRLDDALVARVARLTARPPHRFLRRGLFFAHRDLNEILDLYEKGEKFYLYTGR 101
Cdd:PLN02486    1 QVVTPWEVSAKDGGkIDYDKLVDKFGCQRLDPSLIDRVERLTGRPAHPFLRRGVFFAHRDLEEILDAYEKGEKFYLYTGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 102 GPSSEALHLGHLIPFMFTKYLQDAFKVPLVIQLTDDEKFLWKNLTVEETKRLARENAKDIIACGFDVERTFIFSDFNYVG 181
Cdd:PLN02486   81 GPSSEALHLGHLIPFMFTKYLQDAFKVPLVIQLTDDEKFLWKNLSVEESQRLARENAKDIIACGFDVERTFIFSDFDYVG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 182 GAFYENMVKVARCVTYNKVVGIFGFTPEDHIGKVSFPPVQAVPSFPSSFPHLFSGNDQLRCLIPCAIDQDPYFRMTRDVA 261
Cdd:PLN02486  161 GAFYKNMVKIAKCVTLNQVRGIFGFSGEDNIGKISFPAVQAAPSFPSSFPHLFGGKDKLRCLIPCAIDQDPYFRMTRDVA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 262 PRIGYQKPSLIESRFFPALQGENTKMSASDPNSAIYVTDSAKEIKTKVNKYAFSGGRDSIELHRKLGANLDVDVPIKYLN 341
Cdd:PLN02486  241 PRLGYYKPALIESRFFPALQGESGKMSASDPNSAIYVTDTPKEIKNKINKYAFSGGQDTVEEHRELGANLEVDIPWKYLN 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1002313752 342 FFLEDDNELEHIKKEYKEGRMLTGEVKQRLVAVLSELVARHQRARALVTEEMVDVFMAARPLP 404
Cdd:PLN02486  321 FFLEDDAELERIKKEYGSGRMLTGEVKKRLIEVLTEIVERHQRARAAVTDEMVDAFMAVRPLP 383
 
Name Accession Description Interval E-value
PLN02486 PLN02486
aminoacyl-tRNA ligase
 23-404 0e+00

aminoacyl-tRNA ligase


Pssm-ID: 178104  Cd Length: 383  Bit Score: 823.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752  23 QVVNPWEVSAGKGG-IDYDKLVDQFGCQRLDDALVARVARLTARPPHRFLRRGLFFAHRDLNEILDLYEKGEKFYLYTGR 101
Cdd:PLN02486    1 QVVTPWEVSAKDGGkIDYDKLVDKFGCQRLDPSLIDRVERLTGRPAHPFLRRGVFFAHRDLEEILDAYEKGEKFYLYTGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 102 GPSSEALHLGHLIPFMFTKYLQDAFKVPLVIQLTDDEKFLWKNLTVEETKRLARENAKDIIACGFDVERTFIFSDFNYVG 181
Cdd:PLN02486   81 GPSSEALHLGHLIPFMFTKYLQDAFKVPLVIQLTDDEKFLWKNLSVEESQRLARENAKDIIACGFDVERTFIFSDFDYVG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 182 GAFYENMVKVARCVTYNKVVGIFGFTPEDHIGKVSFPPVQAVPSFPSSFPHLFSGNDQLRCLIPCAIDQDPYFRMTRDVA 261
Cdd:PLN02486  161 GAFYKNMVKIAKCVTLNQVRGIFGFSGEDNIGKISFPAVQAAPSFPSSFPHLFGGKDKLRCLIPCAIDQDPYFRMTRDVA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 262 PRIGYQKPSLIESRFFPALQGENTKMSASDPNSAIYVTDSAKEIKTKVNKYAFSGGRDSIELHRKLGANLDVDVPIKYLN 341
Cdd:PLN02486  241 PRLGYYKPALIESRFFPALQGESGKMSASDPNSAIYVTDTPKEIKNKINKYAFSGGQDTVEEHRELGANLEVDIPWKYLN 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1002313752 342 FFLEDDNELEHIKKEYKEGRMLTGEVKQRLVAVLSELVARHQRARALVTEEMVDVFMAARPLP 404
Cdd:PLN02486  321 FFLEDDAELERIKKEYGSGRMLTGEVKKRLIEVLTEIVERHQRARAAVTDEMVDAFMAVRPLP 383
trpS TIGR00233
tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members ...
 93-398 1.32e-103

tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members of the family have a pfam00458 domain amino-terminal to the region described by this model. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272975 [Multi-domain]  Cd Length: 327  Bit Score: 309.65  E-value: 1.32e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752  93 EKFYLYTGRGPSSeALHLGHLIPFMFTKYLQdAFKVPLVIQLTDDEKFLWKNlTVEETKRLAREN-AKDIIACGFDVERT 171
Cdd:TIGR00233   1 KKFRVLTGIQPSG-KMHLGHYLGAIQTKWLQ-QFGVELFICIADLHAITVKQ-TDPDALRKAREElAADYLAVGLDPEKT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 172 FIFSDFNYvgGAFYENMVKVARCVTYNKVVGIFGFTPEDH-----IGKVSFPPVQAVPSFPSSFPhlfsgndqlrcLIPC 246
Cdd:TIGR00233  78 FIFLQSDY--PEHYELAWLLSCQVTFGELKRMTQFKDKSQaenvpIGLLSYPVLQAADILLYQAD-----------LVPV 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 247 AIDQDPYFRMTRDVAPRIG------YQKPSLIESRFFPALQGENT-KMSASDPNSAIYVTDSAKEIKTKVNKYAFSGGRD 319
Cdd:TIGR00233 145 GIDQDQHLELTRDLAERFNkkfknfFPKPESLISKFFPRLMGLSGkKMSKSDPNSAIFLTDTPKQIKKKIRKAATDGGRV 224

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1002313752 320 SIELHRKLGANLDVDVPIKYLNFFLEDDNELEHIKKEYKEGRMLTGEVKQRLVAVLSELVARHQRARALVTEEMVDVFM 398
Cdd:TIGR00233 225 TLFEHREKPGVPNLLVIYQYLSFFLIDDDKLKEIYEAYKSGKLGYGECKKALIEVLQEFLKEIQERRAEIAEEILDKIL 303
TrpRS_core cd00806
catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) ...
 96-378 3.80e-103

catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) catalytic core domain. TrpRS is a homodimer which attaches Tyr to the appropriate tRNA. TrpRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding


Pssm-ID: 173903 [Multi-domain]  Cd Length: 280  Bit Score: 306.82  E-value: 3.80e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752  96 YLYTGRGPSSeALHLGHLIP-FMFTKYLQDAfKVPLVIQLTDDEKFLWKNLTVEETKRLARENAKDIIACGFDVERTFIF 174
Cdd:cd00806     1 RVLSGIQPSG-SLHLGHYLGaFRFWVWLQEA-GYELFFFIADLHALTVKQLDPEELRQNTRENAKDYLACGLDPEKSTIF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 175 SDFNYvgGAFYENMVKVARCVTYNKVVGIFGFT------PEDHIGKVSFPPVQAVPSFPSSFphlfsgndqlrCLIPCAI 248
Cdd:cd00806    79 FQSDV--PEHYELAWLLSCVVTFGELERMTGFKdksaqgESVNIGLLTYPVLQAADILLYKA-----------CLVPVGI 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 249 DQDPYFRMTRDVAPRIGYQ------KPSLIES--RFFPALQGENTKMSASDPNSAIYVTDSAKEIKTKVNKYAFSGGRDs 320
Cdd:cd00806   146 DQDPHLELTRDIARRFNKLygeifpKPAALLSkgAFLPGLQGPSKKMSKSDPNNAIFLTDSPKEIKKKIMKAATDGGRT- 224

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1002313752 321 ieLHRKLGANLDVDVPIKYLNFFLEDDNELEHIKKEYKEGRMLTGEVKQRLVAVLSEL 378
Cdd:cd00806   225 --EHRRDGGGPGVSNLVEIYSAFFNDDDEELEEIDEYRSGGLGYGECKKLLAEAIQEF 280
tRNA-synt_1b pfam00579
tRNA synthetases class I (W and Y);
90-380 3.17e-22

tRNA synthetases class I (W and Y);


Pssm-ID: 395461 [Multi-domain]  Cd Length: 292  Bit Score: 95.81  E-value: 3.17e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752  90 EKGEKFYLYTGRGPSSeALHLGHLIPFMFTKYLQDAFKVPLVI------QLTD----DEKFLWKNLTVEEtkrlarENAK 159
Cdd:pfam00579   1 KKNRPLRVYSGIDPTG-PLHLGYLVPLMKLRQFQQAGHEVFFLigdlhaIIGDpsksPERKLLSRETVLE------NAIK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 160 DIIACGFDVERTFIFSDFNYVGGAFYE-------NMVKVARCVTYNKVVGIFGFTPEDHIGKVSFPPVQAvpsfpSSFPH 232
Cdd:pfam00579  74 AQLACGLDPEKAEIVNNSDWLEHLELAwllrdlgKHFSLNRMLQFKDVKKRLEQGPGISLGEFTYPLLQA-----YDILL 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 233 LFSGndqlrcLIPCAIDQDPYFRMTRDVAPRIGY---QKPSLIESRFFPALQGENtKMSASDPNSAIYVTDSAKEIKTKV 309
Cdd:pfam00579 149 LKAD------LQPGGSDQWGNIELGRDLARRFNKkifKKPVGLTNPLLTGLDGGK-KMSKSAGNSAIFLDDDPESVYKKI 221

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002313752 310 nKYAFSGGRDSIELHRKLGANLDVDVPIKYLNFFLEDD-NELEHIKKEYKEGRMLTGEVKQRLVAVLSELVA 380
Cdd:pfam00579 222 -QKAYTDPDREVRKDLKLFTFLSNEEIEILEAELGKSPyREAEELLAREVTGLVHGGDLKKAAAEAVNKLLQ 292
TrpS COG0180
Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; ...
 93-387 2.08e-18

Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tryptophanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439950 [Multi-domain]  Cd Length: 330  Bit Score: 85.49  E-value: 2.08e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752  93 EKFYLYTGRGPSSEaLHLGHLIPFMFTKY-LQDafKVPLVIQLTDDEKflwknLTV-EETKRLA---RENAKDIIACGFD 167
Cdd:COG0180     2 SKKRVLSGIQPTGR-LHLGNYLGALKNWVeLQD--EYECFFFIADLHA-----LTTpQDPEELRentREVAADYLAAGLD 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 168 VERTFIF--SD----------FNyvggafyeNMVKVA---RCVTY-NKV---------VGIFGFtpedhigkvsfPPVQA 222
Cdd:COG0180    74 PEKSTIFvqSDvpehaelawlLS--------CLTPLGeleRMPQFkDKSakngkenvnAGLLTY-----------PVLMA 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 223 VPSFpssfphLFSGNdqlrcLIPCAIDQDPYFRMTRDVAPRIGYqkpslIESRFFP---ALQGENT----------KMSA 289
Cdd:COG0180   135 ADIL------LYKAD-----LVPVGEDQKQHLELTRDIARRFNH-----RYGEVFPepeALIPEEGaripgldgrkKMSK 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 290 SDpNSAIYVTDSAKEIKTKVNKyAFSggrDSIELHRKLGANLDVDVPIKYLNFFLeDDNELEHIKKEYKEGRMLTGEVKQ 369
Cdd:COG0180   199 SY-GNTINLLDDPKEIRKKIKS-AVT---DSERLRYDDPGKPEVCNLFTIYSAFS-GKEEVEELEAEYRAGGIGYGDLKK 272

                         330
                  ....*....|....*...
gi 1002313752 370 RLVAVLSELVARHQRARA 387
Cdd:COG0180   273 ALAEAVVEFLAPIRERRA 290
 
Name Accession Description Interval E-value
PLN02486 PLN02486
aminoacyl-tRNA ligase
 23-404 0e+00

aminoacyl-tRNA ligase


Pssm-ID: 178104  Cd Length: 383  Bit Score: 823.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752  23 QVVNPWEVSAGKGG-IDYDKLVDQFGCQRLDDALVARVARLTARPPHRFLRRGLFFAHRDLNEILDLYEKGEKFYLYTGR 101
Cdd:PLN02486    1 QVVTPWEVSAKDGGkIDYDKLVDKFGCQRLDPSLIDRVERLTGRPAHPFLRRGVFFAHRDLEEILDAYEKGEKFYLYTGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 102 GPSSEALHLGHLIPFMFTKYLQDAFKVPLVIQLTDDEKFLWKNLTVEETKRLARENAKDIIACGFDVERTFIFSDFNYVG 181
Cdd:PLN02486   81 GPSSEALHLGHLIPFMFTKYLQDAFKVPLVIQLTDDEKFLWKNLSVEESQRLARENAKDIIACGFDVERTFIFSDFDYVG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 182 GAFYENMVKVARCVTYNKVVGIFGFTPEDHIGKVSFPPVQAVPSFPSSFPHLFSGNDQLRCLIPCAIDQDPYFRMTRDVA 261
Cdd:PLN02486  161 GAFYKNMVKIAKCVTLNQVRGIFGFSGEDNIGKISFPAVQAAPSFPSSFPHLFGGKDKLRCLIPCAIDQDPYFRMTRDVA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 262 PRIGYQKPSLIESRFFPALQGENTKMSASDPNSAIYVTDSAKEIKTKVNKYAFSGGRDSIELHRKLGANLDVDVPIKYLN 341
Cdd:PLN02486  241 PRLGYYKPALIESRFFPALQGESGKMSASDPNSAIYVTDTPKEIKNKINKYAFSGGQDTVEEHRELGANLEVDIPWKYLN 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1002313752 342 FFLEDDNELEHIKKEYKEGRMLTGEVKQRLVAVLSELVARHQRARALVTEEMVDVFMAARPLP 404
Cdd:PLN02486  321 FFLEDDAELERIKKEYGSGRMLTGEVKKRLIEVLTEIVERHQRARAAVTDEMVDAFMAVRPLP 383
PRK12285 PRK12285
tryptophanyl-tRNA synthetase; Reviewed
 24-397 1.56e-127

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 237037 [Multi-domain]  Cd Length: 368  Bit Score: 372.28  E-value: 1.56e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752  24 VVNPWEVSagkGGIDYDKLVDQFGCQRLDDALvarvarLTARPPHRFLRRGLFFAHRDLNEILDLYEKGEKFYLYTGRGP 103
Cdd:PRK12285    5 MVTPWEVS---GIVDYDKLFEEFGIEPFTEVL------PELPEPHPLMRRGIIFGHRDYDKILEAYRNGKPFAVYTGFMP 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 104 SSEaLHLGHLIPFMFTKYLQDaFKVPLVIQLTDDEKFLWKNLTVEETKRLARENAKDIIACGFDVERTFIFSDFNYvgGA 183
Cdd:PRK12285   76 SGP-MHIGHKMVFDELKWHQE-FGANVYIPIADDEAYAARGLSWEETREWAYEYILDLIALGFDPDKTEIYFQSEN--IK 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 184 FYENMVKVARCVTYNKVVGIFGFTPEDHIGKVSFPPVQAVPSFpssFPHLFSGNdqLRCLIPCAIDQDPYFRMTRDVAPR 263
Cdd:PRK12285  152 VYDLAFELAKKVNFSELKAIYGFTGETNIGHIFYPATQAADIL---HPQLEEGP--KPTLVPVGIDQDPHIRLTRDIAER 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 264 I----GYQKPSLIESRFFPALQGenTKMSASDPNSAIYVTDSAKEIKTKVNKyAFSGGRDSIELHRKLGANLDVDVPIKY 339
Cdd:PRK12285  227 LhggyGFIKPSSTYHKFMPGLTG--GKMSSSKPESAIYLTDDPETVKKKIMK-ALTGGRATLEEQRKLGGEPDECVVYEL 303

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1002313752 340 LNFFL-EDDNELEHIKKEYKEGRMLTGEVKQRLVAVLSELVARHQRARALVtEEMVDVF 397
Cdd:PRK12285  304 LLYHLeEDDKELKEIYEECRSGELLCGECKKEAAEKIAEFLKEHQEKREEA-REILEKY 361
trpS TIGR00233
tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members ...
 93-398 1.32e-103

tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members of the family have a pfam00458 domain amino-terminal to the region described by this model. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272975 [Multi-domain]  Cd Length: 327  Bit Score: 309.65  E-value: 1.32e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752  93 EKFYLYTGRGPSSeALHLGHLIPFMFTKYLQdAFKVPLVIQLTDDEKFLWKNlTVEETKRLAREN-AKDIIACGFDVERT 171
Cdd:TIGR00233   1 KKFRVLTGIQPSG-KMHLGHYLGAIQTKWLQ-QFGVELFICIADLHAITVKQ-TDPDALRKAREElAADYLAVGLDPEKT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 172 FIFSDFNYvgGAFYENMVKVARCVTYNKVVGIFGFTPEDH-----IGKVSFPPVQAVPSFPSSFPhlfsgndqlrcLIPC 246
Cdd:TIGR00233  78 FIFLQSDY--PEHYELAWLLSCQVTFGELKRMTQFKDKSQaenvpIGLLSYPVLQAADILLYQAD-----------LVPV 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 247 AIDQDPYFRMTRDVAPRIG------YQKPSLIESRFFPALQGENT-KMSASDPNSAIYVTDSAKEIKTKVNKYAFSGGRD 319
Cdd:TIGR00233 145 GIDQDQHLELTRDLAERFNkkfknfFPKPESLISKFFPRLMGLSGkKMSKSDPNSAIFLTDTPKQIKKKIRKAATDGGRV 224

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1002313752 320 SIELHRKLGANLDVDVPIKYLNFFLEDDNELEHIKKEYKEGRMLTGEVKQRLVAVLSELVARHQRARALVTEEMVDVFM 398
Cdd:TIGR00233 225 TLFEHREKPGVPNLLVIYQYLSFFLIDDDKLKEIYEAYKSGKLGYGECKKALIEVLQEFLKEIQERRAEIAEEILDKIL 303
TrpRS_core cd00806
catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) ...
 96-378 3.80e-103

catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) catalytic core domain. TrpRS is a homodimer which attaches Tyr to the appropriate tRNA. TrpRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding


Pssm-ID: 173903 [Multi-domain]  Cd Length: 280  Bit Score: 306.82  E-value: 3.80e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752  96 YLYTGRGPSSeALHLGHLIP-FMFTKYLQDAfKVPLVIQLTDDEKFLWKNLTVEETKRLARENAKDIIACGFDVERTFIF 174
Cdd:cd00806     1 RVLSGIQPSG-SLHLGHYLGaFRFWVWLQEA-GYELFFFIADLHALTVKQLDPEELRQNTRENAKDYLACGLDPEKSTIF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 175 SDFNYvgGAFYENMVKVARCVTYNKVVGIFGFT------PEDHIGKVSFPPVQAVPSFPSSFphlfsgndqlrCLIPCAI 248
Cdd:cd00806    79 FQSDV--PEHYELAWLLSCVVTFGELERMTGFKdksaqgESVNIGLLTYPVLQAADILLYKA-----------CLVPVGI 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 249 DQDPYFRMTRDVAPRIGYQ------KPSLIES--RFFPALQGENTKMSASDPNSAIYVTDSAKEIKTKVNKYAFSGGRDs 320
Cdd:cd00806   146 DQDPHLELTRDIARRFNKLygeifpKPAALLSkgAFLPGLQGPSKKMSKSDPNNAIFLTDSPKEIKKKIMKAATDGGRT- 224

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1002313752 321 ieLHRKLGANLDVDVPIKYLNFFLEDDNELEHIKKEYKEGRMLTGEVKQRLVAVLSEL 378
Cdd:cd00806   225 --EHRRDGGGPGVSNLVEIYSAFFNDDDEELEEIDEYRSGGLGYGECKKLLAEAIQEF 280
PRK08560 PRK08560
tyrosyl-tRNA synthetase; Validated
 84-314 1.46e-23

tyrosyl-tRNA synthetase; Validated


Pssm-ID: 236286 [Multi-domain]  Cd Length: 329  Bit Score: 100.33  E-value: 1.46e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752  84 EILDLYEKGEKFYLYTGRGPSSEaLHLGHLIPFMFTKYLQDA-FKVplVIQLTDDEKFLWKNLTVEETKRLARENAKDII 162
Cdd:PRK08560   20 ELRELLESKEEPKAYIGFEPSGK-IHLGHLLTMNKLADLQKAgFKV--TVLLADWHAYLNDKGDLEEIRKVAEYNKKVFE 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 163 ACGFDVERT-FIF-SDFnYVGGAFYENMVKVARCVTYNKV---VGIFGFTPEDH-IGKVSFPPVQAVPSFpssfpHL--- 233
Cdd:PRK08560   97 ALGLDPDKTeFVLgSEF-QLDKEYWLLVLKLAKNTTLARArrsMTIMGRRMEEPdVSKLVYPLMQVADIF-----YLdvd 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 234 --FSGNDQLRCLIpcaidqdpyfrMTRDVAPRIGYQKPSLIESRFFPALQGENTKMSASDPNSAIYVTDSAKEIKTKVNK 311
Cdd:PRK08560  171 iaVGGMDQRKIHM-----------LAREVLPKLGYKKPVCIHTPLLTGLDGGGIKMSKSKPGSAIFVHDSPEEIRRKIKK 239


                  ...
gi 1002313752 312 yAF 314
Cdd:PRK08560  240 -AY 241
tRNA-synt_1b pfam00579
tRNA synthetases class I (W and Y);
90-380 3.17e-22

tRNA synthetases class I (W and Y);


Pssm-ID: 395461 [Multi-domain]  Cd Length: 292  Bit Score: 95.81  E-value: 3.17e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752  90 EKGEKFYLYTGRGPSSeALHLGHLIPFMFTKYLQDAFKVPLVI------QLTD----DEKFLWKNLTVEEtkrlarENAK 159
Cdd:pfam00579   1 KKNRPLRVYSGIDPTG-PLHLGYLVPLMKLRQFQQAGHEVFFLigdlhaIIGDpsksPERKLLSRETVLE------NAIK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 160 DIIACGFDVERTFIFSDFNYVGGAFYE-------NMVKVARCVTYNKVVGIFGFTPEDHIGKVSFPPVQAvpsfpSSFPH 232
Cdd:pfam00579  74 AQLACGLDPEKAEIVNNSDWLEHLELAwllrdlgKHFSLNRMLQFKDVKKRLEQGPGISLGEFTYPLLQA-----YDILL 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 233 LFSGndqlrcLIPCAIDQDPYFRMTRDVAPRIGY---QKPSLIESRFFPALQGENtKMSASDPNSAIYVTDSAKEIKTKV 309
Cdd:pfam00579 149 LKAD------LQPGGSDQWGNIELGRDLARRFNKkifKKPVGLTNPLLTGLDGGK-KMSKSAGNSAIFLDDDPESVYKKI 221

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002313752 310 nKYAFSGGRDSIELHRKLGANLDVDVPIKYLNFFLEDD-NELEHIKKEYKEGRMLTGEVKQRLVAVLSELVA 380
Cdd:pfam00579 222 -QKAYTDPDREVRKDLKLFTFLSNEEIEILEAELGKSPyREAEELLAREVTGLVHGGDLKKAAAEAVNKLLQ 292
TrpS COG0180
Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; ...
 93-387 2.08e-18

Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tryptophanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439950 [Multi-domain]  Cd Length: 330  Bit Score: 85.49  E-value: 2.08e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752  93 EKFYLYTGRGPSSEaLHLGHLIPFMFTKY-LQDafKVPLVIQLTDDEKflwknLTV-EETKRLA---RENAKDIIACGFD 167
Cdd:COG0180     2 SKKRVLSGIQPTGR-LHLGNYLGALKNWVeLQD--EYECFFFIADLHA-----LTTpQDPEELRentREVAADYLAAGLD 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 168 VERTFIF--SD----------FNyvggafyeNMVKVA---RCVTY-NKV---------VGIFGFtpedhigkvsfPPVQA 222
Cdd:COG0180    74 PEKSTIFvqSDvpehaelawlLS--------CLTPLGeleRMPQFkDKSakngkenvnAGLLTY-----------PVLMA 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 223 VPSFpssfphLFSGNdqlrcLIPCAIDQDPYFRMTRDVAPRIGYqkpslIESRFFP---ALQGENT----------KMSA 289
Cdd:COG0180   135 ADIL------LYKAD-----LVPVGEDQKQHLELTRDIARRFNH-----RYGEVFPepeALIPEEGaripgldgrkKMSK 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 290 SDpNSAIYVTDSAKEIKTKVNKyAFSggrDSIELHRKLGANLDVDVPIKYLNFFLeDDNELEHIKKEYKEGRMLTGEVKQ 369
Cdd:COG0180   199 SY-GNTINLLDDPKEIRKKIKS-AVT---DSERLRYDDPGKPEVCNLFTIYSAFS-GKEEVEELEAEYRAGGIGYGDLKK 272

                         330
                  ....*....|....*...
gi 1002313752 370 RLVAVLSELVARHQRARA 387
Cdd:COG0180   273 ALAEAVVEFLAPIRERRA 290
PRK12282 PRK12282
tryptophanyl-tRNA synthetase II; Reviewed
 99-386 8.83e-12

tryptophanyl-tRNA synthetase II; Reviewed


Pssm-ID: 183400 [Multi-domain]  Cd Length: 333  Bit Score: 65.65  E-value: 8.83e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752  99 TGRGPSSeALHLGHLIPFM--FTKyLQDAFKVPLVI---Q-LTDDekflWKNLtvEETKRLARENAKDIIACGFDVERTF 172
Cdd:PRK12282    7 TGDRPTG-KLHLGHYVGSLknRVA-LQNEHEQFVLIadqQaLTDN----AKNP--EKIRRNILEVALDYLAVGIDPAKST 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 173 IF--------SDFnyvgGAFYENMVKVARC---VTYNKVVGIFGFtpEDHI--GKVSFPPVQAVpsfpssfphlfsgnDQ 239
Cdd:PRK12282   79 IFiqsqipelAEL----TMYYMNLVTVARLernPTVKTEIAQKGF--GRSIpaGFLTYPVSQAA--------------DI 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 240 LRC---LIPCAIDQDPYFRMTRDVAPRIG--YQKPSLIE--------SRFfPALQGeNTKMSASDPNsAIYVTDSAKEIK 306
Cdd:PRK12282  139 TAFkatLVPVGDDQLPMIEQTREIVRRFNslYGTDVLVEpeallpeaGRL-PGLDG-KAKMSKSLGN-AIYLSDDADTIK 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 307 TKVNKyAFSggrDSIELHRKLGANLDVDVPIKYLNFFLEDDNELEHIKKEYKEGRMLTGEVKQRLVAVLSELVA--RHQR 384
Cdd:PRK12282  216 KKVMS-MYT---DPNHIRVEDPGKVEGNVVFTYLDAFDPDKAEVAELKAHYQRGGLGDVKCKRYLEEVLQELLApiRERR 291


                  ..
gi 1002313752 385 AR 386
Cdd:PRK12282  292 AE 293
TyrRS_core cd00805
catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) ...
 97-378 5.04e-11

catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) catalytic core domain. TyrRS is a homodimer which attaches Tyr to the appropriate tRNA. TyrRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formationof the enzyme bound aminoacyl-adenylate. It contains the class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173902 [Multi-domain]  Cd Length: 269  Bit Score: 62.62  E-value: 5.04e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752  97 LYTGRGPSSEALHLGHLIPFMFTKYLQDA-FKVPLVI-----QLTD--DEKFLWKNLTVEETKRLARENAKDIIACG-FD 167
Cdd:cd00805     3 VYIGFDPTAPSLHLGHLVPLMKLRDFQQAgHEVIVLIgdataMIGDpsGKSEERKLLDLELIRENAKYYKKQLKAILdFI 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 168 VERTFIFSD-FNYVGGAFYENMVKVARCVTYNK------VVGifGFTPEDHIG--KVSFPPVQAVPSFpssfpHL----- 233
Cdd:cd00805    83 PPEKAKFVNnSDWLLSLYTLDFLRLGKHFTVNRmlrrdaVKV--RLEEEEGISfsEFIYPLLQAYDFV-----YLdvdlq 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 234 FSGNDQLRCLIpcaidqdpyfrMTRDVAPRIGYQKPSLIESRFFPALQGenTKMSASDPNSA-IYVTDSAKEIKTKVNKy 312
Cdd:cd00805   156 LGGSDQRGNIT-----------LGRDLIRKLGYKKVVGLTTPLLTGLDG--GKMSKSEGNAIwDPVLDSPYDVYQKIRN- 221

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002313752 313 AFsggrdsielhrklganlDVDVpIKYLNFFLE-DDNELEHIKKEYKEGRmLTGEVKQRLVAVLSEL 378
Cdd:cd00805   222 AF-----------------DPDV-LEFLKLFTFlDYEEIEELEEEHAEGP-LPRDAKKALAEELTKL 269
PRK00927 PRK00927
tryptophanyl-tRNA synthetase; Reviewed
 243-395 1.52e-08

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 234866 [Multi-domain]  Cd Length: 333  Bit Score: 55.87  E-value: 1.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 243 LIPCAIDQDPYFRMTRDVAPRIGYQ-KPSLIESRFF--------PALQGENTKMSASDPN--SAIYVTDSAKEIKTKVNK 311
Cdd:PRK00927  141 LVPVGEDQKQHLELTRDIARRFNNLyGEVFPVPEPLipkvgarvMGLDGPTKKMSKSDPNdnNTINLLDDPKTIAKKIKK 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 312 yAFSggrDSIELHRklganLDVDVPIK--------YLNFFLEDdnELEHIKKEYKEGRMLTGEVKQRLVAVLSELVA--R 381
Cdd:PRK00927  221 -AVT---DSERLRE-----IRYDLPNKpevsnlltIYSALSGE--SIEELEAEYEAGGKGYGDFKKDLAEAVVEFLApiR 289

                         170
                  ....*....|....
gi 1002313752 382 HQRARALVTEEMVD 395
Cdd:PRK00927  290 ERYEELLADPAYLD 303
PTZ00126 PTZ00126
tyrosyl-tRNA synthetase; Provisional
 262-391 6.34e-08

tyrosyl-tRNA synthetase; Provisional


Pssm-ID: 240282 [Multi-domain]  Cd Length: 383  Bit Score: 54.31  E-value: 6.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 262 PRIGYqKPSLIESRFFPALQGENTKMSASDPNSAIYVTDSAKEIKTKVNK---------------YAFS---GGRDSIEL 323
Cdd:PTZ00126  234 KKIKK-KPIILSHHMLPGLLEGQEKMSKSDPNSAIFMEDSEEDVNRKIKKaycppgviegnpilaYFKSivfPAFNSFTV 312

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002313752 324 HRK--LGANldvdvpIKYlnffleddNELEHIKKEYKEGRMLTGEVKQRLVAVLSELVA--RH-----QRARALVTE 391
Cdd:PTZ00126  313 LRKekNGGD------VTY--------TTYEELEKDYLSGALHPGDLKPALAKYLNLMLQpvRDhfqnnPEAKSLLSE 375
tyrS TIGR00234
tyrosyl-tRNA synthetase; This tyrosyl-tRNA synthetase model starts picking up ...
 71-330 4.96e-07

tyrosyl-tRNA synthetase; This tyrosyl-tRNA synthetase model starts picking up tryptophanyl-tRNA synthetases at scores of 0 and below. The proteins found by this model have a deep split between two groups. One group contains bacterial and organellar eukaryotic examples. The other contains archaeal and cytosolic eukaryotic examples. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272976 [Multi-domain]  Cd Length: 378  Bit Score: 51.24  E-value: 4.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752  71 LRRGLF----FAHRDLNEILDlyekgEKFYLYTGRGPSSEALHLGHLIPFMFTKYLQDA-FKVPLVI----QLTDDEKF- 140
Cdd:TIGR00234   9 TKRGLEvqtpEEEKDLLKLLE-----RPLKLYLGFDPTAPSLHLGHLVPLLKLRDFQQAgHEVIVLLgdftALIGDPTGk 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 141 --LWKNLTVEETKRLArENAKDIIACGFDVERTFIFSDFNYVGGAFYENMV-KVARCVTYNKVVGIFGFTP---EDH-IG 213
Cdd:TIGR00234  84 seVRKILTREEVQENA-ENIKKQIARFLDFEKAKFVYNSEWLLKLNYTDFIrLLGKIFTVNRMLRRDAFSSrfeENIsLH 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752 214 KVSFPPVQAVpsfpsSFPHL-----FSGNDQLRCLipcaidqdpyfRMTRDVAPRIGyqkPSLIESRFFPALQG------ 282
Cdd:TIGR00234 163 EFIYPLLQAY-----DFVYLnvdlqLGGSDQWFNI-----------RKGRDLARENL---PSLQFGLTVPLLTPadgekm 223

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1002313752 283 ---ENTKMSASDP--NSAIYVTDSAKEIKTKVNKYAFSGGRDSIELHRKLGAN 330
Cdd:TIGR00234 224 gksLGGAVSLDEGkyDFYQKVINTPDELVKKYLKLFTFLGLEEIEQLVELKGP 276
PRK13354 PRK13354
tyrosyl-tRNA synthetase; Provisional
 73-132 7.64e-05

tyrosyl-tRNA synthetase; Provisional


Pssm-ID: 237360 [Multi-domain]  Cd Length: 410  Bit Score: 44.51  E-value: 7.64e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002313752  73 RGLFFAHRDLNEILDLYEKGEKFYLYTGRGPSSEALHLGHLIPFMFTKYLQDAFKVPLVI 132
Cdd:PRK13354   12 RGAINQETDEEKLRKSLKEGKPLTLYLGFDPTAPSLHIGHLVPLMKLKRFQDAGHRPVIL 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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