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Conserved domains on  [gi|1002234467|ref|XP_015621438|]
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probable aquaporin TIP4-3 [Oryza sativa Japonica Group]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 239)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  8849412|11473620|11964478
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIP super family cl00200
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 3-248 2.84e-71

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


The actual alignment was detected with superfamily member PLN00027:

Pssm-ID: 444743  Cd Length: 252  Bit Score: 218.50  E-value: 2.84e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467   3 KLALGHHREATDPGCLRAVVAELLLTFLFVFSGVGSAMAAAKL-GGGGDTIMGLTAVAAAHALVVAVMVSAGLHVSGGHI 81
Cdd:PLN00027    5 RIAIGTPGEASHPDALKAALAEFISTLIFVFAGEGSGMAFNKLtDNGSTTPAGLVAAALAHAFALFVAVSVGANISGGHV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467  82 NPAVTLGLAAGGHITLFRSALYAAAQLLGSSLACLLLAALTGGEEaVPVHAPAPGVGAARAVAMEAVLTFSLLFAVYATV 161
Cdd:PLN00027   85 NPAVTFGAFIGGNITLLRGILYWIAQLLGSVVACLLLKFSTGGLE-TSAFSLSSGVGVWNAFVFEIVMTFGLVYTVYATA 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467 162 VDRRRA-VGALGPLLVGLVVGANILAGGPYSGASMNPARSFGPALAAGEWADHWIYWVGPLIGGPLAGLVYEGLFMGPPG 240
Cdd:PLN00027  164 VDPKKGdLGIIAPIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWTNHWVYWAGPLIGGGIAGLVYELIFIGSTT 243


                  ....*...
gi 1002234467 241 HEPLPRND 248
Cdd:PLN00027  244 HEQLPTTD 251
 
Name Accession Description Interval E-value
PLN00027 PLN00027
aquaporin TIP; Provisional
 3-248 2.84e-71

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 218.50  E-value: 2.84e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467   3 KLALGHHREATDPGCLRAVVAELLLTFLFVFSGVGSAMAAAKL-GGGGDTIMGLTAVAAAHALVVAVMVSAGLHVSGGHI 81
Cdd:PLN00027    5 RIAIGTPGEASHPDALKAALAEFISTLIFVFAGEGSGMAFNKLtDNGSTTPAGLVAAALAHAFALFVAVSVGANISGGHV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467  82 NPAVTLGLAAGGHITLFRSALYAAAQLLGSSLACLLLAALTGGEEaVPVHAPAPGVGAARAVAMEAVLTFSLLFAVYATV 161
Cdd:PLN00027   85 NPAVTFGAFIGGNITLLRGILYWIAQLLGSVVACLLLKFSTGGLE-TSAFSLSSGVGVWNAFVFEIVMTFGLVYTVYATA 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467 162 VDRRRA-VGALGPLLVGLVVGANILAGGPYSGASMNPARSFGPALAAGEWADHWIYWVGPLIGGPLAGLVYEGLFMGPPG 240
Cdd:PLN00027  164 VDPKKGdLGIIAPIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWTNHWVYWAGPLIGGGIAGLVYELIFIGSTT 243


                  ....*...
gi 1002234467 241 HEPLPRND 248
Cdd:PLN00027  244 HEQLPTTD 251
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 11-231 2.77e-57

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 182.13  E-value: 2.77e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467  11 EATDPGCLRAVVAELLLTFLFVFSGVGSAMAAAKLGGGgDTIMGLTAVAAAHALVVAVMVSAGLHVSGGHINPAVTLGLA 90
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSS-LAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467  91 AGGHITLFRSALYAAAQLLGSSLACLLLAALTGGEEAVPVHA--PAPGVGAARAVAMEAVLTFSLLFAVYATVVDRRRA- 167
Cdd:pfam00230  80 VGRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFAntLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGs 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1002234467 168 VGALGPLLVGLVVGANILAGGPYSGASMNPARSFGPALAAGEWADHWIYWVGPLIGGPLAGLVY 231
Cdd:pfam00230 160 LGTVAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 19-232 4.84e-48

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 158.57  E-value: 4.84e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467  19 RAVVAELLLTFLFVFSGVGSAMAAAKLGGGGDTIMGLtavAAAHALVVAVMVSAGLHVSGGHINPAVTLGLAAGGHITLF 98
Cdd:cd00333     1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGGASGGLLGI---ALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLI 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467  99 RSALYAAAQLLGSSLACLLLAALTGGE-----------EAVPVHAPAPGVGAARAVAMEAVLTFSLLFAVYATVVDRRRA 167
Cdd:cd00333    78 RVIPYIIAQLLGAILGAALLYGLYYGLyleflgannivAGIFGTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNGP 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1002234467 168 -VGALGPLLVGLVVGANILAGGPYSGASMNPARSFGPALAAG---EWADHWIYWVGPLIGGPLAGLVYE 232
Cdd:cd00333   158 pPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGlarHWHYFWVYWVGPLIGAIAGALVYD 226
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 18-235 1.30e-40

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 139.49  E-value: 1.30e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467  18 LRAVVAELLLTFLFVFSGVGSAMAAAKLGGGGDTIM-----GLTAVAAAHALVvavmvsaglHVSGGHINPAVTLGLAAG 92
Cdd:COG0580     3 MKRLLAEFLGTFILVLLGCGVVAVLAGTKGGIGWLGialawGLAVLAGVYAFG---------HISGAHLNPAVTLALAVA 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467  93 GHITLFRSALYAAAQLLGS----------SLACLLLAALTGGEEAVPVHAPAPGVGAARAVAMEAVLTFSLLFAVYAtVV 162
Cdd:COG0580    74 GRFPWKDVLPYIIAQLLGAflgaalvyliYGGHFDATEDGGAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILG-IT 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1002234467 163 DRRRAVGALGPLLVGLVVGANILAGGPYSGASMNPARSFGPALAA------GEWADHWIYWVGPLIGGPLAGLVYEGLF 235
Cdd:COG0580   153 DKRAAPGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHalgkggSDWGYLWVPIVAPILGAALAALLYRALF 231
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 23-231 6.05e-40

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 137.43  E-value: 6.05e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467  23 AELLLTFLFVFSGVGSAMAAAKLGGGGDTIMG-LTAVAAAHALVVAVMVSAGLHVSGGHINPAVTLGLAAGGHITLFRSA 101
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGAYGAVGGGqFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467 102 LYAAAQLLGSSLACLLLAALTGGEEAVPVHA---PAPGVGAARAVAMEAVLTFSLLFAVYATVVDRRRA-VGALGPLLVG 177
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVngsASAGVSSGQAFFVEFIGTAILVLVIFATTDDRNRVpRGGFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1002234467 178 LVVGANILAGGPYSGASMNPARSFGPALAAG--EWADHWIYWVGPLIGGPLAGLVY 231
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFAGlaGWGNHWVYWVGPIIGAILGALVY 216
 
Name Accession Description Interval E-value
PLN00027 PLN00027
aquaporin TIP; Provisional
 3-248 2.84e-71

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 218.50  E-value: 2.84e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467   3 KLALGHHREATDPGCLRAVVAELLLTFLFVFSGVGSAMAAAKL-GGGGDTIMGLTAVAAAHALVVAVMVSAGLHVSGGHI 81
Cdd:PLN00027    5 RIAIGTPGEASHPDALKAALAEFISTLIFVFAGEGSGMAFNKLtDNGSTTPAGLVAAALAHAFALFVAVSVGANISGGHV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467  82 NPAVTLGLAAGGHITLFRSALYAAAQLLGSSLACLLLAALTGGEEaVPVHAPAPGVGAARAVAMEAVLTFSLLFAVYATV 161
Cdd:PLN00027   85 NPAVTFGAFIGGNITLLRGILYWIAQLLGSVVACLLLKFSTGGLE-TSAFSLSSGVGVWNAFVFEIVMTFGLVYTVYATA 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467 162 VDRRRA-VGALGPLLVGLVVGANILAGGPYSGASMNPARSFGPALAAGEWADHWIYWVGPLIGGPLAGLVYEGLFMGPPG 240
Cdd:PLN00027  164 VDPKKGdLGIIAPIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWTNHWVYWAGPLIGGGIAGLVYELIFIGSTT 243


                  ....*...
gi 1002234467 241 HEPLPRND 248
Cdd:PLN00027  244 HEQLPTTD 251
PLN00166 PLN00166
aquaporin TIP2; Provisional
 1-248 1.72e-59

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 188.61  E-value: 1.72e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467   1 MAKLALGHHREATDPGCLRAVVAELLLTFLFVFSGVGSAMAAAKLGGGGD-TIMGLTAVAAAHALVVAVMVSAGLHVSGG 79
Cdd:PLN00166    1 MVKIEFGSLGDSFSVASLKAYLSEFIATLLFVFAGVGSAIAFAKLTSDAAlDPAGLVAVAVAHAFALFVGVSIAANISGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467  80 HINPAVTLGLAAGGHITLFRSALYAAAQLLGSSLACLLLAALTGGEeAVPVHAPAPGVGAARAVAMEAVLTFSLLFAVYA 159
Cdd:PLN00166   81 HLNPAVTLGLAIGGNITIITGFFYWIAQCLGSIVACLLLVFVTNGE-SVPTHGVAAGLGAIEGVVMEIVVTFALVYTVYA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467 160 TVVDRRR-AVGALGPLLVGLVVGANILAGGPYSGASMNPARSFGPALAAGEWADHWIYWVGPLIGGPLAGLVYEGLFMGp 238
Cdd:PLN00166  160 TAADPKKgSLGTIAPIAIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGDFSQIWIYWVGPLVGGALAGLIYGDVFIG- 238

                         250
                  ....*....|
gi 1002234467 239 pGHEPLPRND 248
Cdd:PLN00166  239 -SYAAAPTSE 247
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 11-231 2.77e-57

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 182.13  E-value: 2.77e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467  11 EATDPGCLRAVVAELLLTFLFVFSGVGSAMAAAKLGGGgDTIMGLTAVAAAHALVVAVMVSAGLHVSGGHINPAVTLGLA 90
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSS-LAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467  91 AGGHITLFRSALYAAAQLLGSSLACLLLAALTGGEEAVPVHA--PAPGVGAARAVAMEAVLTFSLLFAVYATVVDRRRA- 167
Cdd:pfam00230  80 VGRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFAntLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGs 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1002234467 168 VGALGPLLVGLVVGANILAGGPYSGASMNPARSFGPALAAGEWADHWIYWVGPLIGGPLAGLVY 231
Cdd:pfam00230 160 LGTVAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 19-232 4.84e-48

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 158.57  E-value: 4.84e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467  19 RAVVAELLLTFLFVFSGVGSAMAAAKLGGGGDTIMGLtavAAAHALVVAVMVSAGLHVSGGHINPAVTLGLAAGGHITLF 98
Cdd:cd00333     1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGGASGGLLGI---ALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLI 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467  99 RSALYAAAQLLGSSLACLLLAALTGGE-----------EAVPVHAPAPGVGAARAVAMEAVLTFSLLFAVYATVVDRRRA 167
Cdd:cd00333    78 RVIPYIIAQLLGAILGAALLYGLYYGLyleflgannivAGIFGTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNGP 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1002234467 168 -VGALGPLLVGLVVGANILAGGPYSGASMNPARSFGPALAAG---EWADHWIYWVGPLIGGPLAGLVYE 232
Cdd:cd00333   158 pPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGlarHWHYFWVYWVGPLIGAIAGALVYD 226
PLN00167 PLN00167
aquaporin TIP5; Provisional
 10-232 1.54e-45

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 153.14  E-value: 1.54e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467  10 REATDPGCLRAVVAELLLTFLFVFSGVGSAMAAAKLGGGGDTI-MGLTAVAAAHALVVAVMVSAGLHVSGGHINPAVTLG 88
Cdd:PLN00167   14 QQSVTRNALRSYLAEFISTFFFVFAAVGSAMSSRKLMPDAASDpSSLLIVAIANAFALSSAVYIAANISGGHVNPAVTFG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467  89 LAAGGHITLFRSALYAAAQLLGSSLACLLLAALTGGEEaVPVHAPAPGVGAARAVAMEAVLTFSLLFAVYATVVDRRRAV 168
Cdd:PLN00167   94 MAVGGHISVPTAMFYWISQMLASVMACLFLKVTTVGQH-VPTYKIAEEMTGFGASVLEGVLTFGLVYTVYAAGDPRRGLL 172

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1002234467 169 GALGPLLVGLVVGANILAGGPYSGASMNPARSFGPALAAGEWADHWIYWVGPLIGGPLAGLVYE 232
Cdd:PLN00167  173 GAIGPLAIGLVAGANVLAAGPFSGGSMNPACAFGSAVVAGSFKNQAVYWVGPLLGGAVAGLLYD 236
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 18-235 1.30e-40

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 139.49  E-value: 1.30e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467  18 LRAVVAELLLTFLFVFSGVGSAMAAAKLGGGGDTIM-----GLTAVAAAHALVvavmvsaglHVSGGHINPAVTLGLAAG 92
Cdd:COG0580     3 MKRLLAEFLGTFILVLLGCGVVAVLAGTKGGIGWLGialawGLAVLAGVYAFG---------HISGAHLNPAVTLALAVA 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467  93 GHITLFRSALYAAAQLLGS----------SLACLLLAALTGGEEAVPVHAPAPGVGAARAVAMEAVLTFSLLFAVYAtVV 162
Cdd:COG0580    74 GRFPWKDVLPYIIAQLLGAflgaalvyliYGGHFDATEDGGAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILG-IT 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1002234467 163 DRRRAVGALGPLLVGLVVGANILAGGPYSGASMNPARSFGPALAA------GEWADHWIYWVGPLIGGPLAGLVYEGLF 235
Cdd:COG0580   153 DKRAAPGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHalgkggSDWGYLWVPIVAPILGAALAALLYRALF 231
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 23-231 6.05e-40

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 137.43  E-value: 6.05e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467  23 AELLLTFLFVFSGVGSAMAAAKLGGGGDTIMG-LTAVAAAHALVVAVMVSAGLHVSGGHINPAVTLGLAAGGHITLFRSA 101
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGAYGAVGGGqFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467 102 LYAAAQLLGSSLACLLLAALTGGEEAVPVHA---PAPGVGAARAVAMEAVLTFSLLFAVYATVVDRRRA-VGALGPLLVG 177
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVngsASAGVSSGQAFFVEFIGTAILVLVIFATTDDRNRVpRGGFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1002234467 178 LVVGANILAGGPYSGASMNPARSFGPALAAG--EWADHWIYWVGPLIGGPLAGLVY 231
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFAGlaGWGNHWVYWVGPIIGAILGALVY 216
PLN00026 PLN00026
aquaporin NIP; Provisional
 19-234 1.47e-26

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 104.56  E-value: 1.47e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467  19 RAVVAELLLTFLFVFSGVGSAMAAAKLGGGgDTIMGLtaVAAAHALVVAVMVSAGlHVSGGHINPAVTLGLAAGGHITLF 98
Cdd:PLN00026   72 RKLGAEFVGTFILIFAATAGPIVNQKYDGA-ETLIGN--AACAGLAVMIVILSTG-HISGAHLNPSLTIAFAALRHFPWK 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467  99 RSALYAAAQLLGSSLACLLLAA-----LTGGeeavpvhAPAPGVGAARAVAMEAVLTFSLLFAVYATVVDRRrAVGALGP 173
Cdd:PLN00026  148 HVPAYIAAQVSASICASFALKGvfhpfMSGG-------VTVPSVSTGQAFALEFIITFNLLFVVTAVATDTR-AVGELAG 219

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1002234467 174 LLVGLVVGANILAGGPYSGASMNPARSFGPALAAGEWADHWIYWVGPLIGGPLAGLVYEGL 234
Cdd:PLN00026  220 IAVGATVMLNILVAGPSTGGSMNPVRTLGPAVAAGNYRAIWIYLVAPTLGALAGAGTYTAV 280
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 18-239 1.13e-25

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 101.47  E-value: 1.13e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467  18 LRAVVAELLLTFLFVFSgVGSAMAAAKLGGGGdtiMGLTAVAAAHALVVAVMVSAGLHVSGGHINPAVTLGLAAGGHITL 97
Cdd:PLN00183   45 ARMVLAEMVGTFILMFC-VCGIIASTQLSGGE---VGLLEYAATAGLTVVVVVFSIGSISGAHVNPSVTIAFATFGHFPW 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467  98 FRSALYAAAQLLGSSLACLLLAALTGGEEAVPVHAPAPGVGAARAVamEAVLTFSLLFaVYATVVDRRRAVGALGPLLVG 177
Cdd:PLN00183  121 SKVPLYITAQTVGSVLATYVGVSVYGVKADLMTTKPAQGCSSAFWV--EFIATFIVMF-LAASLTSQPQSLGHLSGFVIG 197

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002234467 178 LVVGANILAGGPYSGASMNPARSFGPALAAGEWADHWIYWVGPLIGGPLAGLVYEGLFMGPP 239
Cdd:PLN00183  198 IAIGLAVLITGPVSGGSMNPARSLGPAIVSWDFKDIWIYITAPTIGAVAGALMFHLLRLRTQ 259
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 21-231 1.83e-25

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 101.14  E-value: 1.83e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467  21 VVAELLLTFLFVFSGVGSaMAAAKLGGGGDTIMGLTAVAAAHALVVAVmvSAGlHVSGGHINPAVTLGLAAGGHITLFRS 100
Cdd:PLN00182   45 LIAEMIGTYFIIFSGCGV-VVVNVLYGGTITFPGICVTWGLIVMVMIY--STG-HISGAHFNPAVTVTFAIFRRFPWYQV 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467 101 ALYAAAQLLGSSLACLLLAALTggeEAVP--VHAPAPGVGAARAVAMEAVLTFSLLFAVYATVVDRRrAVGALGPLLVGL 178
Cdd:PLN00182  121 PLYIGAQLTGSLLASLTLRLMF---NVTPeaFFGTTPTDSSGQALVAEIIISFLLMFVISGVATDSR-AVGELAGIAVGM 196

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1002234467 179 VVGANILAGGPYSGASMNPARSFGPALAAGEWADHWIYWVGPLIGGPLAGLVY 231
Cdd:PLN00182  197 TIILNVFVAGPISGASMNPARSLGPAIVMGRYKGIWVYIVGPFVGIIAGGFVY 249
PLN00184 PLN00184
aquaporin NIP1; Provisional
 18-231 2.41e-25

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 101.25  E-value: 2.41e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467  18 LRAVVAELLLTFLFVFSGVgsamAAAKLGGGGDTIMGLTAVAAAHALVVAVMVSAGLHVSGGHINPAVTLGLAAGGHITL 97
Cdd:PLN00184   54 LQKLIAEVLGTYFLVFTGC----ASVVVNMQNDNVVTLPGIAIVWGLTIMVLIYSLGHISGAHINPAVTIAFASCGRFPL 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467  98 FRSALYAAAQLLGSSLACLLLAALTG-------GEEAVPVhAPAPGVGAARAVAMEAVLTFSLLFAVYATVVDRRrAVGA 170
Cdd:PLN00184  130 KQVPAYVISQVIGSTLAAATLRLLFGldhdvcsGKHDVFI-GSSPVGSDLQAFVMEFIVTFYLMFIISGVATDNR-AIGE 207

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1002234467 171 LGPLLVGLVVGANILAGGPYSGASMNPARSFGPALAAGEWADHWIYWVGPLIGGPLAGLVY 231
Cdd:PLN00184  208 LAGLAIGSTVLLNVLIAAPVSSASMNPGRSLGPAMVYGCYKGIWIYIVAPTLGAIAGAWVY 268
PRK05420 PRK05420
aquaporin Z; Provisional
 18-235 3.98e-21

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 88.49  E-value: 3.98e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467  18 LRAVVAELLLTFLFVFSGVGSAMAAAKLGGGGdtiMGLTAVAAAHALVVAVMVSAGLHVSGGHINPAVTLGLAAGGHITL 97
Cdd:PRK05420    2 FKKLAAEFFGTFWLVFGGCGSAVLAAAFPELG---IGFLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFPA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467  98 FRSALYAAAQLLGSSLACLLLAALTGGEEAVPV------------HAPApGVGAARAVAMEAVLTFSLLFaVYATVVDRR 165
Cdd:PRK05420   79 KELVPYIIAQVVGGIAAAAVLYLIASGKAGFDLagsgfasngygeHSPG-GYSLLAALVCEVVLTAFFLL-VILGATDKR 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002234467 166 RAVGaLGPLLVGLVVGANILAGGPYSGASMNPARSFGPALAAGEWA--DHWIYWVGPLIGGPLAGLVYEGLF 235
Cdd:PRK05420  157 APAG-FAPIAIGLALTLIHLISIPVTNTSVNPARSTGVALFVGGWAleQLWLFWVAPIVGAIIGGLIYRLLL 227
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 18-240 1.25e-14

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 71.70  E-value: 1.25e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467  18 LRAVVAELLLTFLFVFSGVGsAMAAAKLGGGGDTIMGLTAVAAAHALVVAVmvsAGLHVSGGHINPAVTLGLAAGGHITL 97
Cdd:PTZ00016   50 VREYVAEFLGTFVLLFFGEG-VVATTHTVGNNGDYLAITIGWGLGVTFGLL---VSAGISGGHLNPAVTLGNAVFGKFPW 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467  98 FRSALYAAAQLLG----------------SSLACLLLAALTGGEEAVPVHAPAPGVGAARAVAMEAVLTFSLLFAVYATV 161
Cdd:PTZ00016  126 KKLPGYFVAQLLGafvgaacvyglyygffKDHGIPELPWETMANGFAGVFATYPREGNFYAIFSELILTAILLLVILAIT 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467 162 VDRRRAVGALGPLLVGLVVGANILAGGPYSGASMNPARSFGP-ALAAGEWADH---------WIYWVGPLIGGPLAGLVY 231
Cdd:PTZ00016  206 DPNNCPAFNYLPVAVGLLVFVIGISFGGNTGYALNPARDLGPrLFSAILWGSEvftkdnyyfWVPLVAPFVGAVLGMFLY 285


                  ....*....
gi 1002234467 232 EgLFMGPPG 240
Cdd:PTZ00016  286 D-KFIPPLI 293
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 141-241 5.06e-03

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 37.23  E-value: 5.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234467 141 RAVAMEAVLTFSLLFAVYATVVDRRRAVGALGPLL-----VGLVVGANILAGGPYSGASMNPARSFGPALAAG-EWADHW 214
Cdd:cd00333     1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGGASGGLLgialaWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRfPLIRVI 80

                          90       100
                  ....*....|....*....|....*..
gi 1002234467 215 IYWVGPLIGGPLAGLVYEGLFMGPPGH 241
Cdd:cd00333    81 PYIIAQLLGAILGAALLYGLYYGLYLE 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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