BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234790  172 LQYQLFAESQDYgshgERVRNACWGYLCQS-ATLELREVLPKLSSQTLHALLTSDELWVPNEEKRFELAL 240
Cdd:smart00875   2 LGIRRFADAHGL----EELAEKALRFILQNfSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVL 67

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234790  62 SGAFSDVVVEAMGATYRLHRLIIS-RSAYFRNMLHGPWREAGAPTVVLhiddPNIDSEAIAIALAYLYGqPPKLNDNNAF 140
Cdd:pfam00651   7 QGELCDVTLVVGDKEFRAHKAVLAaCSPYFKALFSGQESESSVSEITL----DDVSPEDFEALLEFMYT-GKLISEENVD 81

                          90       100
                  ....*....|....*....|....
gi 1002234790 141 RVLAAASFLDLQDLCTICTDFIIS 164
Cdd:pfam00651  82 DLLAAADKLQIPSLVDKCEEFLIK 105

kelch-like protein; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234790  68 VVVEAMGATYRLHRLII-SRSAYFRNMLHGPWREAgapTVVLhiddpNIDSEAIAIALAYLYGQPPKLNDNNAFRVLAAA 146
Cdd:PHA03098   14 IIIVNGGGIIKVHKIILsSSSEYFKKMFKNNFKEN---EINL-----NIDYDSFNEVIKYIYTGKINITSNNVKDILSIA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234790 147 SFLDLQDLCTICTDFIISELWTSNFLQYQLFAESQDYgshgERVRNACWGY-LCQSATLELREVLPKLSSQTLHALLTSD 225
Cdd:PHA03098   86 NYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGC----KKLYSAAYNYiRNNIELIYNDPDFIYLSKNELIKILSDD 161

                  ....*...
gi 1002234790 226 ELWVPNEE 233
Cdd:PHA03098  162 KLNVSSED 169

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234790  65 FSDVVVEAMGATYRLHRLIIS-RSAYFRNMLHGPWREAGAPTVVLhiddPNIDSEAIAIALAYLYGQPPKLNDNNAFRVL 143
Cdd:cd18186     1 LCDVTLVVGGREFPAHRAVLAaRSPYFRAMFSSGMKESSSSEIEL----DDVSPEAFEALLDYIYTGELELSEENVEELL 76

                  ....*.
gi 1002234790 144 AAASFL 149
Cdd:cd18186    77 AAADKL 82

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234790   67 DVVVEAMGATYRLHRLIIS-RSAYFRNMLHGPWREAGAPTVVLhiddPNIDSEAIAIALAYLYGQPPKLNDNNAFRVLAA 145
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAaHSPYFKALFSSDFKESDKSEIYL----DDVSPEDFRALLNFLYTGKLDLPEENVEELLEL 76

                           90       100
                   ....*....|....*....|.
gi 1002234790  146 ASFLDLQDLCTICTDFIISEL 166
Cdd:smart00225  77 ADYLQIPGLVELCEEFLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234790  61 GSGAFSDVVVEAMGATYRLHRLIISR-SAYFRNMLHGPWREAGAPTVVLHiddpNIDSEAIAIALAYLYGQPPKLNDNNA 139
Cdd:cd18276    17 ELAELTDVVLVAEGEKFPCHRLVLAAfSPYFKAMFTCGLMECSQREVVLH----DITAESVSIILNYMYSSDLHLTNSNV 92

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1002234790 140 FRVLAAASFLDLQDLCTICTDFIISELWTSN 170
Cdd:cd18276    93 QGVATAAFFLQMEDIFSVCQKYMMDHMDASN 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 16 (BTBD16); BTBD16 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234790  63 GAFSDVVVEAMGATYRLHRLIISRSAYFRNMLHgpwreagAPTVVLHIDDPNIDSEAIAIALAYLYGQPPKLNDNNAFRV 142
Cdd:cd18291    10 SACPDVVLECLGSFWELHSPYLCKSETLAELLK-------PVTISLNINDPLVTKEAFAVALGNLYNSEVEVNVEDAVGV 82

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1002234790 143 LAAASFLDLQDLCTICTDFIISELWTSNFLQY 174
Cdd:cd18291    83 LAAAALLRFPTLFQKCVKVMISSISSSTVCKF 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234790  66 SDVVVEAMGATYRLHRLIISR-SAYFRNMLHGPWREAGAPTVVLHiddpNIDSEAIAIALAYLYGQPPKLNDNNAFRVLA 144
Cdd:cd18234     2 CDVILIAGDRRIPAHRLVLSAvSDYFAAMFTNDVREATEEEIKLK----DVDPDALWTLVQYCYTGRLELKEDNVESLLA 77

                          90       100
                  ....*....|....*....|....*...
gi 1002234790 145 AASFLDLQDLCTICTDFIISELWTSNFL 172
Cdd:cd18234    78 TACLLQLSEVVEACCGFLMKQLHPSNCL 105

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234790  65 FSDVVVEAMGATYRLHRLIIS-RSAYFRNMLHGPWRE-----AGAPTVVLHiddpNIDSEAIAIALAYLYGQPPKLNDNN 138
Cdd:cd18296    17 FPDVCFQVEGHRFPCHKAFFCgRSDYFKALLRDHFAEseennGSIPVVTLH----DVSPEVFAIVLYYIYTDDTDLPPEN 92

                          90       100
                  ....*....|....*....|....*...
gi 1002234790 139 AFRVLAAASFLDLQDLCTICTDFIISEL 166
Cdd:cd18296    93 AYDVLYVADMYLLPGLKRLCGTVLAQSL 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234790  67 DVVVEAMGATYRLHRLII-SRSAYFRNMLHGPWREAGAPTVVLHiddpNIDSEAIAIALAYLYGQPPKLNDNNAFRVLAA 145
Cdd:cd18235    23 DVILVADGVEIPAHRVVLaSCSPYFHAMFTGDLSESRANRVTLQ----DVDGKALLLLIDYVYTAEIQVTEENVQVLLPA 98

                          90       100
                  ....*....|....*....|.
gi 1002234790 146 ASFLDLQDLCTICTDFIISEL 166
Cdd:cd18235    99 ANLLQLTDVRDACCDFLQSQL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234790  62 SGAFSDVVVEAMGATYRLHRLIISRSA-YFRNMLHGPWREAGAPTVVLHiddpNIDSEAIAIALAYLYGQPPKLNDNNAF 140
Cdd:cd18251    20 SGILFDVVLVVEGKPIEAHRILLAASCdYFRGMFAGGLREMQQTEVLIH----GVSYNAMCKILDFIYTSELELSLDNVQ 95

                          90       100       110
                  ....*....|....*....|....*....|
gi 1002234790 141 RVLAAASFLDLQDLCTICTDFIISelWTSN 170
Cdd:cd18251    96 ETLTAACQLQIPEVIGFCCDFLMS--WVDN 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234790  62 SGAFSDVVVEAMGATYRLHRLIISR-SAYFRNMLHGPWREAGAPTVVLHiddpNIDSEAIAIALAYLYGQPPKLNDNNAF 140
Cdd:cd18340    24 HNKFVDCVLKIKEKEFPCHRLVLAAcSPYFRAMFLSDLEESKKREIVLE----DVDPDVMGKILHYIYTSEIEITEQNVQ 99

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1002234790 141 RVLAAASFLDLQDLCTICTDFIISELWTSNFL 172
Cdd:cd18340   100 DIFAAANMFQIPSIFTVCVSFLQKRLCLSNCL 131

kelch-like protein; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234790  68 VVVEAMGATYRLHRLII-SRSAYFRNMLHGPWREAgapTVVLhiddpNIDSEAIAIALAYLYGQPPKLNDNNAFRVLAAA 146
Cdd:PHA03098   14 IIIVNGGGIIKVHKIILsSSSEYFKKMFKNNFKEN---EINL-----NIDYDSFNEVIKYIYTGKINITSNNVKDILSIA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234790 147 SFLDLQDLCTICTDFIISELWTSNFLQYQLFAESQDYgshgERVRNACWGY-LCQSATLELREVLPKLSSQTLHALLTSD 225
Cdd:PHA03098   86 NYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGC----KKLYSAAYNYiRNNIELIYNDPDFIYLSKNELIKILSDD 161

                  ....*...
gi 1002234790 226 ELWVPNEE 233
Cdd:PHA03098  162 KLNVSSED 169

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234790  65 FSDVVVeAMGAT-YRLHRLII-SRSAYFRNMLHGPWREAGAPTVVLHIDDPNIDSEaiaiALAYLYGQPPKLNDNNAFRV 142
Cdd:cd18314     6 FSDVVL-CVGDRkFFAHRIVLcARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFET----VLKYMYTGQVTLSEENVLDL 80

                          90
                  ....*....|....*.
gi 1002234790 143 LAAASFLDLQDLCTIC 158
Cdd:cd18314    81 LMLASKYQVPDLEKLC 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234790  67 DVVVEAMGATYRLHRLIISR-SAYFRNMLHGPWREAGAPTVvlHIDDpnIDSEAIAIALAYLYGQPPKLNDNNAFRVLAA 145
Cdd:cd18339    23 DVTIVAEDVEIEAHRVVLAAcSPYFCAMFTGDMSESKAKKI--EIKD--VDGQTLSKLIDYIYTAEIEVTEENVQVLLPA 98

                          90       100
                  ....*....|....*....|.
gi 1002234790 146 ASFLDLQDLCTICTDFIISEL 166
Cdd:cd18339    99 ASLLQLMDVRQNCCDFLQSQL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234790  68 VVVEamGATYRLHRLIISR-SAYFRNMLHGPWREAGAPTVVLhiddPNIDSEAIAIALAYLYGQPPKLNDNNAFRVLAAA 146
Cdd:cd01165     3 LVVE--GEKFHVNKELLAQsSEYFRALFRGGFRESGQAEINL----RDISPEDFRALLEFLYGGKRDLDASNLLELLEAA 76

                  ...
gi 1002234790 147 SFL 149
Cdd:cd01165    77 NFL 79

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234790  65 FSDVVVEAMGATYRLHRLIISR-SAYFRNMLHGPWREAGAPTVVLHIDDPNIdSEAIaiaLAYLYGQPPKLNDNNAFRVL 143
Cdd:cd18341    27 FVDCTLKAGDKSLPCHRLILAAcSPYFREYFLSEESEEKKKEVVLDNVDPNI-MDMI---LKYLYSAEIDLNDGNVQDIF 102

                          90       100
                  ....*....|....*....|....*....
gi 1002234790 144 AAASFLDLQDLCTICTDFIISELWTSNFL 172
Cdd:cd18341   103 ALASRFQIPSVFTVCVTYLQKRLSPANCL 131

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234790  53 DHVQ------AEGFGSGAFSDV--VVEamGATYRLHRLII-SRSAYFRNMLHGPWREAGAPTVVLHidDPNidSEAIAIA 123
Cdd:cd18287     4 DHVHflsediGALFLNEEYSDVtfVVE--EKRFPAHRVILaARSEYFRALLYGGMRESQQSEIELK--DTN--AEAFKAL 77

                  ....*
gi 1002234790 124 LAYLY 128
Cdd:cd18287    78 LKYIY 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234790  63 GAFSDVVVEAMGATYRLHR-LIISRSAYFRNmLHGPWREAGAPTVVLHIDDpnIDSEAIAIALAYLYGQPPKLNDNNAFR 141
Cdd:cd18230    19 GILCDVCIIVEGKIFKAHKnVLLGSSRYFKT-LYCQVQKTSDQATVTHLDI--VTAQGFKAIIDFMYSAHLALTSKNVIE 95

                          90       100
                  ....*....|....*....|....*
gi 1002234790 142 VLAAASFLDLQDLCTICTDFIISEL 166
Cdd:cd18230    96 VMSAASYLQMTDIVQACHNFIKAAL 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234790  65 FSDV--VVEamGATYRLHRLI-ISRSAYFRNMLHGPWREAGAPTVVLhiddPNIDSEAIAIALAYLY-GQPPKLNDNN-- 138
Cdd:cd18297    12 MSDVtfLVE--GRPFYAHKIVlVTASDRFKSMLSSGSTEAQTPVIEI----PDIRYDIFQLMMQYLYtGGVESLDVAQdd 85

                          90       100
                  ....*....|....*....|
gi 1002234790 139 AFRVLAAASFLDLQDLCTIC 158
Cdd:cd18297    86 ALELLRAASFFQLDGLKRHC 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234790  65 FSDVVVEAMGATYRLHRLIISR-SAYFRNMLHGPWREAGAPtvvlHIDDPNIDSEAIAIALAYLYGQPPKLNDNNAFRVL 143
Cdd:cd18270    26 LTDIVLIVEGTEFPCHKMVLATcSSYFRAMFMSGLSESKQT----HVHLRNVDAATLQIIITYAYTGNLAINDSTVEQLY 101

                          90       100
                  ....*....|....*....|....*..
gi 1002234790 144 AAASFLDLQDLCTICTDFIISELWTSN 170
Cdd:cd18270   102 ETACFLQVEDVLQRCREYLIKKINAEN 128

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234790  67 DVVVEAMGATYRLHRLIISR-SAYFRNMLHGPWREAGAPTVVLHiddpNIDSEAIAIALAYLYGQPPKLNDNNAFRVLAA 145
Cdd:cd18338    23 DVTIVAEDVEIAAHRVVLAAcSPYFHAMFTGEMSESRAKRVRIK----EVDGWTLKMLIDYVYTAEIQVTEENVQVLLPA 98

                          90       100
                  ....*....|....*....|.
gi 1002234790 146 ASFLDLQDLCTICTDFIISEL 166
Cdd:cd18338    99 AGLLQLQDVKKTCCEFLESQL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234790  67 DVVVEAMGATYRLHRLIISR-SAYFRNMLHGPWREAGAPTVVLHiddpNIDSEAIAIALAYLYGQPPKLNDNNAFRVLAA 145
Cdd:cd18237    23 DVILIVEGREIKAHRVVLAAaSHFFHLMFTSNMTESKSSEVELK----DAEPDIIELLVEFAYTARISVNSNNVQSLLDA 98

                          90       100
                  ....*....|....*....|....*..
gi 1002234790 146 ASFLDLQDLCTICTDFIISELWTSNFL 172
Cdd:cd18237    99 ANQYQIEPVKKMCVDFLKEQLDASNCL 125

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234790  62 SGAFSDVVVEAMGATYRLHR-LIISRSAYFRNMLHGPWREAGAPTVVLHIDDPNIdsEAIAIALAYLYGQPPKLNDNNAF 140
Cdd:cd18201    18 KGILCDVNIVVSGKVFRAHKnILVAGSRFFKTLYCFTNKESCDQTTVTHLDVVAV--QGFSVILDFMYSGNLVLTSQNAI 95

                          90       100
                  ....*....|....*....|..
gi 1002234790 141 RVLAAASFLDLQDLCTICTDFI 162
Cdd:cd18201    96 EVMSVASYLQMTEVVQSCRNFI 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234790  65 FSDVVVEAMGATYRLHRLII-SRSAYFRNMLHGPWREAGAPTVVLHiddpNIDSEAIAIALAYLYGQPPKLNDNNAFRVL 143
Cdd:cd18250    21 FFDVTLCAGGREFPCHRTVLaAASSYFRAMFAGELRESRADRVVLH----GVSAEILGLLLDFSYTGRVTVTQDNVEALL 96

                          90       100
                  ....*....|....*....|....*..
gi 1002234790 144 AAASFLDLQDLCTICTDFIISELWTSN 170
Cdd:cd18250    97 RAADLFQFPSVKEACCAYLQQRLDVSN 123

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234790  62 SGAFSDVVVEAMGATYRLHR-LIISRSAYFRNMLhgpwREAGAP-TVVLHIDDPNIDSEAIAIALAYLYGQPPKLNDNNA 139
Cdd:cd18312     6 TGEPSDITVRVGNTTFHLHKfPLCSKSGYFKRLA----SSSSESdPSEIELNDFPGGAEAFELVAKFCYGMPINLTATNV 81

                          90
                  ....*....|....
gi 1002234790 140 FRVLAAASFLDLQD 153
Cdd:cd18312    82 VGLRCAAEYLEMTE 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234790  67 DVVVEAMGATYRLHRLIISR-SAYFRNMLHGPWREAGAPTVVLHiddpNIDSEAIAIALAYLYGQPPKLNDNNAFRVLAA 145
Cdd:cd18336    21 DVLLIAGNLKIPAHRLVLSAvSDYFAAMFTNDVREAKQEEIKME----GVDPDALKALVHYAYTGVLELKEDTIESLLAA 96

                          90       100
                  ....*....|....*....|....*..
gi 1002234790 146 ASFLDLQDLCTICTDFIISELWTSNFL 172
Cdd:cd18336    97 ACLLQLSQVIDVCCNFLMKQLHPSNCL 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234790  62 SGAFSDVVVEAMGATYRLHRLIIS-RSAYFRNMLhgpwREAGAPTVVLHIDDPNIDSEAIAIALAYLYGQPPKLNDNNAF 140
Cdd:cd18306    15 NRQFCDVILQVGGHEIPAHRAVLAcASPYLFELF----SSDSDGESILTVKLDGLDPDAVEVLVNYAYTSRLEVPADLVK 90