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Conserved domains on  [gi|1002234851|ref|XP_015621634|]
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protein DETOXIFICATION 12 [Oryza sativa Japonica Group]

Protein Classification

MATE family efflux transporter( domain architecture ID 10192067)

MATE (multidrug and toxic compound extrusion) family efflux transporter functions in protecting cells against oxidative stress and bile salts and may be part of the SOS system; similar to Arabidopsis thaliana MATE proteins which confer aluminum tolerance

Gene Ontology:  GO:0016020|GO:0015297|GO:0022857
PubMed:  26246409|33774036|31866287
TCDB:  2.A.66

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MATE_eukaryotic cd13132
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ...
 51-487 4.07e-166

Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.


:

Pssm-ID: 240537 [Multi-domain]  Cd Length: 436  Bit Score: 476.68  E-value: 4.07e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  51 EAGRLASLAAPMIAVALLQLMMQLISTVMVGHLGEVALAGAAIANSLTNVSGFSVLMGLACGLETICGQAYGAEQYHKLA 130
Cdd:cd13132     1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 131 LYMYRSIIVLLVVSVPIAIIWVFIPEVLPLIGQQPEIASEVGKYALWLIPGLFAFTVAQCLSKFLQTQSLIFPMVLSSSI 210
Cdd:cd13132    81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 211 TLALFIPLCWFMVYKVGMGNAGAALSVSICDWVEVTVLGLYIVLSPSCEKTRAPLTWEAFSGIGSFLRLAVPSALMICLE 290
Cdd:cd13132   161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCLE 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 291 WWSYELLVLLSGILPnPALETSVLSICISTVVLVYNLPHGIGTAASVRVSNELGAGNPEGARLVVGVALSVILCSAVLVS 370
Cdd:cd13132   241 WWAFEILVLLAGLLP-GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVA 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 371 VTLLALRHFIGIAFSNEEEVINYVTRMVPVLSISVITDSLQGVLSGVSRGCGWQHLGAYVNLGAFYLVGVPVALFFGFAM 450
Cdd:cd13132   320 ILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFVL 399

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1002234851 451 HLGGMGFWMGMVAGGATQVTLLSIITAMTNWRKMAEK 487
Cdd:cd13132   400 GLGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
 
Name Accession Description Interval E-value
MATE_eukaryotic cd13132
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ...
 51-487 4.07e-166

Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.


Pssm-ID: 240537 [Multi-domain]  Cd Length: 436  Bit Score: 476.68  E-value: 4.07e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  51 EAGRLASLAAPMIAVALLQLMMQLISTVMVGHLGEVALAGAAIANSLTNVSGFSVLMGLACGLETICGQAYGAEQYHKLA 130
Cdd:cd13132     1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 131 LYMYRSIIVLLVVSVPIAIIWVFIPEVLPLIGQQPEIASEVGKYALWLIPGLFAFTVAQCLSKFLQTQSLIFPMVLSSSI 210
Cdd:cd13132    81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 211 TLALFIPLCWFMVYKVGMGNAGAALSVSICDWVEVTVLGLYIVLSPSCEKTRAPLTWEAFSGIGSFLRLAVPSALMICLE 290
Cdd:cd13132   161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCLE 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 291 WWSYELLVLLSGILPnPALETSVLSICISTVVLVYNLPHGIGTAASVRVSNELGAGNPEGARLVVGVALSVILCSAVLVS 370
Cdd:cd13132   241 WWAFEILVLLAGLLP-GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVA 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 371 VTLLALRHFIGIAFSNEEEVINYVTRMVPVLSISVITDSLQGVLSGVSRGCGWQHLGAYVNLGAFYLVGVPVALFFGFAM 450
Cdd:cd13132   320 ILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFVL 399

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1002234851 451 HLGGMGFWMGMVAGGATQVTLLSIITAMTNWRKMAEK 487
Cdd:cd13132   400 GLGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
matE TIGR00797
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ...
 61-402 1.35e-61

putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]


Pssm-ID: 273273 [Multi-domain]  Cd Length: 342  Bit Score: 205.17  E-value: 1.35e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  61 PMIAVALLQLMMQLISTVMVGHLGEVALAGAAIANSLTNVsGFSVLMGLACGLETICGQAYGAEQYHKLALYMYRSIIVL 140
Cdd:TIGR00797   1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVFMF-LFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 141 LVVSVPIAIIWVF-IPEVLPLIGQQPEIASEVGKYALWLIPGLFAFTVAQCLSKFLQTQSLIFPMVLSSSITLALFIPLC 219
Cdd:TIGR00797  80 LLLGLPVLLVGYFfIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 220 WFMVYKV--GMGNAGAALSVSICDWVEVTVLGLYIVLSPSCEKTRAPLTWEAFSGIGSFLRLAVPSALMICLEWWSYELL 297
Cdd:TIGR00797 160 YILIFGKfgFLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 298 VLLSGILPnpALETSVLSICISTVVLVYNLPHGIGTAASVRVSNELGAGNPEGARLVVGVALSVILCSAVLVSVTLLALR 377
Cdd:TIGR00797 240 ALLVARLG--SIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFR 317

                         330       340
                  ....*....|....*....|....*
gi 1002234851 378 HFIGIAFSNEEEVINYVTRMVPVLS 402
Cdd:TIGR00797 318 EFIARLFTNDPEVLELAAIYLIFVA 342
NorM COG0534
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
54-464 3.75e-57

Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];


Pssm-ID: 440300 [Multi-domain]  Cd Length: 427  Bit Score: 195.75  E-value: 3.75e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  54 RLASLAAPMIAVALLQLMMQLISTVMVGHLGEVALAGAAIANSLTNVSgFSVLMGLACGLETICGQAYGAEQYHKLALYM 133
Cdd:COG0534     9 LLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLL-IALGIGLGVGGTALVAQALGAGDREEARRVL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 134 YRSIIVLLVVSVPIAII-WVFIPEVLPLIGQQPEIASEVGKYALWLIPGLFAFTVAQCLSKFLQTQSLIFPMVLSSSITL 212
Cdd:COG0534    88 GQALLLALLLGLLLTLLgLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIGN 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 213 ALFIPLCWFMVYKVGMGNAGAALSVSICDWVEVTVLGLYIVLSPSCEKTRAPLTWEAFSGIGSFLRLAVPSALMICLEWW 292
Cdd:COG0534   168 VLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRPDRKILKRILRIGLPAGLQQLAESL 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 293 SYELLVLLSGILPNPALetSVLSICISTVVLVYNLPHGIGTAASVRVSNELGAGNPEGARLVVGVALSVILCSAVLVSVT 372
Cdd:COG0534   248 GFLVLNALVARLGTAAV--AAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLLALL 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 373 LLALRHFIGIAFSNEEEVINYVTRMVPVLSISVITDSLQGVLSGVSRGCGWQHLGAYVNLGAFYLVGVPVALFFGFaMHL 452
Cdd:COG0534   326 LFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAF-LGL 404

                         410
                  ....*....|..
gi 1002234851 453 GGMGFWMGMVAG 464
Cdd:COG0534   405 GLTGVWLALPIG 416
PRK01766 PRK01766
multidrug efflux protein; Reviewed
 50-474 6.94e-35

multidrug efflux protein; Reviewed


Pssm-ID: 234981 [Multi-domain]  Cd Length: 456  Bit Score: 136.10  E-value: 6.94e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  50 AEAGRLASLAAPMIAVALLQLMMQLISTVMVGHLGEVALAGAAIANSLTnVSGFSVLMGLACGLETICGQAYGAEQYHKL 129
Cdd:PRK01766    9 SEARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGTSIW-LPVILFGHGLLLALTPIVAQLNGAGRRERI 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 130 ALYMYRSIIVLLVVSVPI-AIIWVFIPEVLPLIGQQPEIASEVGKY---ALWLIPGLFAFTVAQCLSKFLqtqSLIFPMV 205
Cdd:PRK01766   88 AHQVRQGLWLALFLSVLImLVLYNAVPPILNMMNLEPEVADIAVGYlhaLLWGIPAYLLYQVLRSFIDGL---GKTKPTM 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 206 LSSSITLALFIPLCWFMVY-KVGM---GNAGAALSVSICDWVEVTVLGLYIVLSPSCEKTRAPLTWEA--FSGIGSFLRL 279
Cdd:PRK01766  165 VIGFLGLLINIPLNYIFIYgKFGFpelGGVGCGVATAIVYWVMFLAMLIYIKRARRFRDFRLFKGLYKpdWAVIKRLLKL 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 280 AVPSALMICLEWWSYELLVLLSGilpnpALETSVLS---ICISTVVLVYNLPHGIGTAASVRVSNELGAGNPEGARLVVG 356
Cdd:PRK01766  245 GLPIGLAIFFEVSLFAVVTLLVS-----PLGTVTVAahqIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDARQYAY 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 357 VALSVILCSAVLVSVTLLALRHFIGIAFSNEEEVINYVTRMVPVLSISVITDSLQGVLSGVSRGCGWQHLGAYVNLGAFY 436
Cdd:PRK01766  320 IGLAVGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRVIFFITFIAYW 399

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 1002234851 437 LVGVPVALFFGFAMHLGGMGFWMGMVAGGATQVTLLSI 474
Cdd:PRK01766  400 VLGLPLGYILALTDPMGPFGFWIGLIIGLTAAAILLLL 437
MatE pfam01554
MatE; The MatE domain
 61-221 7.35e-28

MatE; The MatE domain


Pssm-ID: 334587 [Multi-domain]  Cd Length: 161  Bit Score: 108.81  E-value: 7.35e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  61 PMIAVALLQLMMQLISTVMVGHLGEVALAGAAIANSLTNVSgFSVLMGLACGLETICGQAYGAEQYHKLALYMYRSIIVL 140
Cdd:pfam01554   1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLI-FMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 141 LVVSVPIAII-WVFIPEVLPLIGQQPEIASEVGKYALWLIPGLFAFTVAQCLSKFLQTQSLIFPMVLSSSITLALFIPLC 219
Cdd:pfam01554  80 LLLSLPIALLvLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159


                  ..
gi 1002234851 220 WF 221
Cdd:pfam01554 160 YL 161
 
Name Accession Description Interval E-value
MATE_eukaryotic cd13132
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ...
 51-487 4.07e-166

Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.


Pssm-ID: 240537 [Multi-domain]  Cd Length: 436  Bit Score: 476.68  E-value: 4.07e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  51 EAGRLASLAAPMIAVALLQLMMQLISTVMVGHLGEVALAGAAIANSLTNVSGFSVLMGLACGLETICGQAYGAEQYHKLA 130
Cdd:cd13132     1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 131 LYMYRSIIVLLVVSVPIAIIWVFIPEVLPLIGQQPEIASEVGKYALWLIPGLFAFTVAQCLSKFLQTQSLIFPMVLSSSI 210
Cdd:cd13132    81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 211 TLALFIPLCWFMVYKVGMGNAGAALSVSICDWVEVTVLGLYIVLSPSCEKTRAPLTWEAFSGIGSFLRLAVPSALMICLE 290
Cdd:cd13132   161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCLE 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 291 WWSYELLVLLSGILPnPALETSVLSICISTVVLVYNLPHGIGTAASVRVSNELGAGNPEGARLVVGVALSVILCSAVLVS 370
Cdd:cd13132   241 WWAFEILVLLAGLLP-GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVA 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 371 VTLLALRHFIGIAFSNEEEVINYVTRMVPVLSISVITDSLQGVLSGVSRGCGWQHLGAYVNLGAFYLVGVPVALFFGFAM 450
Cdd:cd13132   320 ILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFVL 399

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1002234851 451 HLGGMGFWMGMVAGGATQVTLLSIITAMTNWRKMAEK 487
Cdd:cd13132   400 GLGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
matE TIGR00797
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ...
 61-402 1.35e-61

putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]


Pssm-ID: 273273 [Multi-domain]  Cd Length: 342  Bit Score: 205.17  E-value: 1.35e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  61 PMIAVALLQLMMQLISTVMVGHLGEVALAGAAIANSLTNVsGFSVLMGLACGLETICGQAYGAEQYHKLALYMYRSIIVL 140
Cdd:TIGR00797   1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVFMF-LFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 141 LVVSVPIAIIWVF-IPEVLPLIGQQPEIASEVGKYALWLIPGLFAFTVAQCLSKFLQTQSLIFPMVLSSSITLALFIPLC 219
Cdd:TIGR00797  80 LLLGLPVLLVGYFfIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 220 WFMVYKV--GMGNAGAALSVSICDWVEVTVLGLYIVLSPSCEKTRAPLTWEAFSGIGSFLRLAVPSALMICLEWWSYELL 297
Cdd:TIGR00797 160 YILIFGKfgFLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 298 VLLSGILPnpALETSVLSICISTVVLVYNLPHGIGTAASVRVSNELGAGNPEGARLVVGVALSVILCSAVLVSVTLLALR 377
Cdd:TIGR00797 240 ALLVARLG--SIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFR 317

                         330       340
                  ....*....|....*....|....*
gi 1002234851 378 HFIGIAFSNEEEVINYVTRMVPVLS 402
Cdd:TIGR00797 318 EFIARLFTNDPEVLELAAIYLIFVA 342
NorM COG0534
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
54-464 3.75e-57

Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];


Pssm-ID: 440300 [Multi-domain]  Cd Length: 427  Bit Score: 195.75  E-value: 3.75e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  54 RLASLAAPMIAVALLQLMMQLISTVMVGHLGEVALAGAAIANSLTNVSgFSVLMGLACGLETICGQAYGAEQYHKLALYM 133
Cdd:COG0534     9 LLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLL-IALGIGLGVGGTALVAQALGAGDREEARRVL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 134 YRSIIVLLVVSVPIAII-WVFIPEVLPLIGQQPEIASEVGKYALWLIPGLFAFTVAQCLSKFLQTQSLIFPMVLSSSITL 212
Cdd:COG0534    88 GQALLLALLLGLLLTLLgLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIGN 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 213 ALFIPLCWFMVYKVGMGNAGAALSVSICDWVEVTVLGLYIVLSPSCEKTRAPLTWEAFSGIGSFLRLAVPSALMICLEWW 292
Cdd:COG0534   168 VLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRPDRKILKRILRIGLPAGLQQLAESL 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 293 SYELLVLLSGILPNPALetSVLSICISTVVLVYNLPHGIGTAASVRVSNELGAGNPEGARLVVGVALSVILCSAVLVSVT 372
Cdd:COG0534   248 GFLVLNALVARLGTAAV--AAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLLALL 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 373 LLALRHFIGIAFSNEEEVINYVTRMVPVLSISVITDSLQGVLSGVSRGCGWQHLGAYVNLGAFYLVGVPVALFFGFaMHL 452
Cdd:COG0534   326 LFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAF-LGL 404

                         410
                  ....*....|..
gi 1002234851 453 GGMGFWMGMVAG 464
Cdd:COG0534   405 GLTGVWLALPIG 416
MATE_NorM_like cd13131
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ...
 51-474 5.87e-57

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.


Pssm-ID: 240536 [Multi-domain]  Cd Length: 435  Bit Score: 195.41  E-value: 5.87e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  51 EAGRLASLAAPMIAVALLQLMMQLISTVMVGHLGEVALAGAAIANSLTNVSgFSVLMGLACGLETICGQAYGAEQYHKLA 130
Cdd:cd13131     1 ELRALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSLWFPV-FTFGMGLLLAVTPLVAQAHGAGDRRRIR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 131 LYMYRSIIVLLVVSVPIAIIWVFIPEVLPLIGQQPEIASEVGKYALWLIPGLFAFTVAQCLSKFLQTQSLIFPMVLSSSI 210
Cdd:cd13131    80 RAVRQGLWLALLLSLPLMLLLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 211 TLALFIPLCWFMVY-KVG---MGNAGAALSVSICDWVEVTVLGLYIVLSPSCEKTRAPLTWEAFSG--IGSFLRLAVPSA 284
Cdd:cd13131   160 ALVLNIPLNYVLIFgKFGlpaLGGAGAGLATAIVYWLMFLALAFYIRRHKRFRRYRLFARFWRPDWarLKELLRLGLPIG 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 285 LMICLEWWSYELLVLLSGIlpnpaLETSVLS---ICISTVVLVYNLPHGIGTAASVRVSNELGAGNPEGARLVVGVALSV 361
Cdd:cd13131   240 LTIFFEVSLFAAVALLMGR-----LGTTVLAahqIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVGLGL 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 362 ILCSAVLVSVTLLALRHFIGIAFSNEEEVINYVTRMVPVLSISVITDSLQGVLSGVSRGCGWQHLGAYVNLGAFYLVGVP 441
Cdd:cd13131   315 GVGFAALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLALISYWGIGLP 394

                         410       420       430
                  ....*....|....*....|....*....|...
gi 1002234851 442 VALFFGFAMHLGGMGFWMGMVAGGATQVTLLSI 474
Cdd:cd13131   395 LGYLLAFTTGLGAFGVWIGLIIGLALAAILLLW 427
MATE_NorM_like cd13137
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
 54-482 2.23e-39

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240542 [Multi-domain]  Cd Length: 432  Bit Score: 148.04  E-value: 2.23e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  54 RLASLAAPMIAVALLQLMMQLISTVMVGHLGEVALAGAAIANSLTNVsGFSVLMGLACGLETICGQAYGAEQYHKLALYM 133
Cdd:cd13137     2 RIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWL-LLVLNMALGTGTVALVSQSYGAGDYERARRAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 134 YRSIIVLLVVSVPIAII-WVFIPEVLPLIGQQPEIASEVGKYALWLIPGLFAFTVAQCLSKFLQTQSL-IFPMVLSSsIT 211
Cdd:cd13137    81 GQSLLLALLLSLPLALLgLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDtKTPMYIMI-IV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 212 LALFIPLCWFMVYKV----GMGNAGAALSvSICDWVEVTVLGLYIVLSPSCEKTRAPLTWE-AFSGIGSFLRLAVPSALM 286
Cdd:cd13137   160 NVLNIVLDYVLIFGLwgfpGLGVAGAALA-TVISRVVGALLLLFLLLRGRLPIKISFKGFRlDRKIIKKLLRIGLPAGLE 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 287 ICLEWWSYELLVLLSGILPNPALetSVLSICISTVVLVYNLPHGIGTAASVRVSNELGAGNPEGARLVVGVALSVILCSA 366
Cdd:cd13137   239 QLLRSLGFLVLLAIVASYGTAAL--AAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLFM 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 367 VLVSVTLLALRHFIGIAFSNEEEVINYVTRMVPVLSISVITDSLQGVLSGVSRGCGWQHLGAYVNLGAFYLVGVPVALFF 446
Cdd:cd13137   317 GLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAYLL 396

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 1002234851 447 GFAMHLGGMGFWMGMVAGGATQVTLLSIITAMTNWR 482
Cdd:cd13137   397 GFVLGLGLTGIWLAMFVDTIVRAILLLYRFRKGKWK 432
MATE_like_7 cd13133
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 54-475 1.76e-36

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240538 [Multi-domain]  Cd Length: 438  Bit Score: 139.97  E-value: 1.76e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  54 RLASLAAPMIAVALLQLMMQLISTVMVGHLGEVALAGAAIAnSLTNVSGFSVLMGLACGLETICGQAYGAEQYHKLALYM 133
Cdd:cd13133     6 EILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPA-GVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGRVL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 134 YRSIIVLLVVSVPIAII-WVFIPEVLPLIGQQPEIASEVGKYALWLIPGLFAFTVAQCLSKFLQTQSLIFPMVLSSSITL 212
Cdd:cd13133    85 WQGLYFSLLLAPLLALLsALAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLVMV 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 213 ALFIPLCWFMVYKVG----MGNAGAALSVSICDWVEVTVLGLYIVLSPSCEKTRAPLTWEA-FSGIGSFLRLAVPSALMI 287
Cdd:cd13133   165 VVNIVLDYALIFGKLgfpaMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRRRFGLRRAWRFdRELLRRILRLGLPSGLQF 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 288 CLEWWSYELLVLLSGILpnPALETSVLSICISTVVLVYNLPHGIGTAASVRVSNELGAGNPEGARLVVGVALSVILCSAV 367
Cdd:cd13133   245 FLDVGAFTVFFLLIGRL--GTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLALAYML 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 368 LVSVTLLALRHFIGIAFSNE---EEVINYVTRMVPVLSISVITDSLQGVLSGVSRGCGWQHLGAYVNLGAFYLVGVPVAL 444
Cdd:cd13133   323 LLGILFLLFPELLLSIFTPGadfALIAELAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAELIVAWLYLLPPAY 402

                         410       420       430
                  ....*....|....*....|....*....|.
gi 1002234851 445 FFGFaMHLGGMGFWMGMVAggatQVTLLSII 475
Cdd:cd13133   403 LLVV-LGAGLAGAWTVETV----YVIVLALI 428
PRK01766 PRK01766
multidrug efflux protein; Reviewed
 50-474 6.94e-35

multidrug efflux protein; Reviewed


Pssm-ID: 234981 [Multi-domain]  Cd Length: 456  Bit Score: 136.10  E-value: 6.94e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  50 AEAGRLASLAAPMIAVALLQLMMQLISTVMVGHLGEVALAGAAIANSLTnVSGFSVLMGLACGLETICGQAYGAEQYHKL 129
Cdd:PRK01766    9 SEARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGTSIW-LPVILFGHGLLLALTPIVAQLNGAGRRERI 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 130 ALYMYRSIIVLLVVSVPI-AIIWVFIPEVLPLIGQQPEIASEVGKY---ALWLIPGLFAFTVAQCLSKFLqtqSLIFPMV 205
Cdd:PRK01766   88 AHQVRQGLWLALFLSVLImLVLYNAVPPILNMMNLEPEVADIAVGYlhaLLWGIPAYLLYQVLRSFIDGL---GKTKPTM 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 206 LSSSITLALFIPLCWFMVY-KVGM---GNAGAALSVSICDWVEVTVLGLYIVLSPSCEKTRAPLTWEA--FSGIGSFLRL 279
Cdd:PRK01766  165 VIGFLGLLINIPLNYIFIYgKFGFpelGGVGCGVATAIVYWVMFLAMLIYIKRARRFRDFRLFKGLYKpdWAVIKRLLKL 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 280 AVPSALMICLEWWSYELLVLLSGilpnpALETSVLS---ICISTVVLVYNLPHGIGTAASVRVSNELGAGNPEGARLVVG 356
Cdd:PRK01766  245 GLPIGLAIFFEVSLFAVVTLLVS-----PLGTVTVAahqIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDARQYAY 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 357 VALSVILCSAVLVSVTLLALRHFIGIAFSNEEEVINYVTRMVPVLSISVITDSLQGVLSGVSRGCGWQHLGAYVNLGAFY 436
Cdd:PRK01766  320 IGLAVGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRVIFFITFIAYW 399

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 1002234851 437 LVGVPVALFFGFAMHLGGMGFWMGMVAGGATQVTLLSI 474
Cdd:PRK01766  400 VLGLPLGYILALTDPMGPFGFWIGLIIGLTAAAILLLL 437
MATE_like cd12082
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ...
 59-472 2.15e-32

Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240527 [Multi-domain]  Cd Length: 420  Bit Score: 128.21  E-value: 2.15e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  59 AAPMIAVALLQLMMQLISTVMVGHLGEVALAGAAIANSLTNVSgFSVLMGLACGLETICGQAYGAEQYHKLALYMYRSII 138
Cdd:cd12082     1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALL-IALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 139 VLLVVSVPIAIIWVFIPEVLP-LIGQQPEIASEVGKYALWLIPGLFAFTVAQCLSKFLQTQSLIFPMVLSSSITLALFIP 217
Cdd:cd12082    80 LAILLGLLLAALLLFFSPLILsLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNIL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 218 LCWFMVY---KVGMGNAGAALSVSICDWVEVTVLGLYIVLSPSCEKTRAPLTWEAFSGIGSFLRLAVPSALMICLEWWSY 294
Cdd:cd12082   160 LDPLLIFglgPPELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 295 ELLVLLSGILPNPAlETSVLSICISTVVLVYNLPHGIGTAASVRVSNELGAGNPEGARLVVGVALSVILCSAVLVSVTLL 374
Cdd:cd12082   240 LIIVAIVAAFGGAA-ALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLIL 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 375 ALRHFIGIAFSNEEEVINYVTRMVPVLSISVITDSLQGVLSGVSRGCGWQHLGAYVNLGAFYLVGVPVAlFFGFAMHLGG 454
Cdd:cd12082   319 LFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLA-YVLAYLGLGL 397

                         410
                  ....*....|....*...
gi 1002234851 455 MGFWMGMVAGGATQVTLL 472
Cdd:cd12082   398 YGIWLALVISLILAALVL 415
MatE pfam01554
MatE; The MatE domain
 61-221 7.35e-28

MatE; The MatE domain


Pssm-ID: 334587 [Multi-domain]  Cd Length: 161  Bit Score: 108.81  E-value: 7.35e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  61 PMIAVALLQLMMQLISTVMVGHLGEVALAGAAIANSLTNVSgFSVLMGLACGLETICGQAYGAEQYHKLALYMYRSIIVL 140
Cdd:pfam01554   1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLI-FMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 141 LVVSVPIAII-WVFIPEVLPLIGQQPEIASEVGKYALWLIPGLFAFTVAQCLSKFLQTQSLIFPMVLSSSITLALFIPLC 219
Cdd:pfam01554  80 LLLSLPIALLvLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159


                  ..
gi 1002234851 220 WF 221
Cdd:pfam01554 160 YL 161
MATE_like_8 cd13134
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 55-463 1.09e-27

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240539 [Multi-domain]  Cd Length: 438  Bit Score: 114.91  E-value: 1.09e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  55 LASLAAPMIAVALLQLMMQLISTVMVGHLGEVALAGAAIANSLTNVsGFSVLMGLACGLETICGQAYGAEQYHKLALYMY 134
Cdd:cd13134     5 LFALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQILFL-LILIFSFISTGTSILIAQYLGAKDKKKARQIAG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 135 RSIIVLLVVSVPIAIIWVFIPEVLP-LIGQQPEIASEVGKYALWLIPGLFAFTVAQCLSKFLQTQSLIFPMVLSSSITLA 213
Cdd:cd13134    84 VALLFNLLLGLVFSLLLLFFGAELLrLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIMNI 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 214 LFIPLCWFMVYKVG----MGNAGAALSVSICDWVEVTVLGLYIVLspsceKTRAPLTWEAFSGI-----GSFLRLAVPSA 284
Cdd:cd13134   164 LNIVGNYLLIFGWFglpkLGVAGVAISTVISRAVGLVLLFILLFR-----KLKIRFRLKDLRPFpkkllKKILKIGLPSA 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 285 L-MIClewWSYELLVLLSGILPNPALETSVLSICISTVVLVYNLPHGIGTAASVRVSNELGAGNPEGARLVVGVALSVIL 363
Cdd:cd13134   239 GeELS---YNLSQTVITAFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGL 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 364 CSAVLVSVTLLALRHFIGIAFSNEEEVINYVTRMVPVLSISVITDSLQGVLSGVSRGCGWQHLGAYVNLGAFYLVGVPVA 443
Cdd:cd13134   316 LVSLAVALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIISMWGISVPLA 395

                         410       420
                  ....*....|....*....|
gi 1002234851 444 LFFGFAMHLGGMGFWMGMVA 463
Cdd:cd13134   396 YLLGIVLGLGLLGVWIAFAA 415
MATE_yoeA_like cd13138
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
 55-482 3.80e-26

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240543 [Multi-domain]  Cd Length: 431  Bit Score: 110.63  E-value: 3.80e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  55 LASLAAPMIAVALLQLMMQLISTVMVGH-LGEVALAGAAIANSLTNVSgFSVLMGLACGLETICGQAYGAEQYHKLALYM 133
Cdd:cd13138     5 LLLFALPLLLSNLLQQLYNLVDLLIVGQfLGVAALAAVSNGSPIIFLL-TAIGMGLSMGGTILISQYIGAKDEEKAKKAV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 134 YRSIIVLLVVSVPIAII-WVFIPEVLPLIGQQPEIASEVGKYALWLIPGLFAFTVAQCLSKFLQTQ-----SLIFpMVLS 207
Cdd:cd13138    84 GTLLVLFLILGIVLTILgLLFAPPILRLMNTPAEILELAVSYLRICFLGIPFIFGYNAYSAILRGLgdsktPLYF-VIIA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 208 SSITLALFIplcwFMVYKVGMGNAGAAL--------SVSICdWVEVTVLGLYIVLSPSCEKTRAPLTWEafsgigsFLRL 279
Cdd:cd13138   163 CVLNIILDL----LFIAVFHMGVAGAALatviaqaiSVLLA-LYYLRKKKLPFKLSLKDFRFDKEILKE-------ILKI 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 280 AVPSALMICLEWWSYelLVLLSGILPNPALETSVLSICISTVVLVYNLPHGIGTAASVRVSNELGAGNPEGARLVV--GV 357
Cdd:cd13138   231 GLPSALQQSLVSISF--LIINSIVNSYGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLrtGI 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 358 ALSVIlCSAVLVSVTLLALRHFIGIaFSNEEEVINYVTRMVPVLSISVITDSLQGVLSGVSRGCGWQHLGAYVNLGAFYL 437
Cdd:cd13138   309 IISLI-IGLIIILLVFFFAPQLLGL-FTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWL 386

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1002234851 438 VGVPVALFFGFAMHLGGMGFWMGMVAGGATQVTLLSIITAMTNWR 482
Cdd:cd13138   387 VRIPLAYLLSRLTGLGLFGIWLAMPISNILSAIICIIYYRKGRWK 431
MATE_like_12 cd13142
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 55-483 2.18e-24

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240547 [Multi-domain]  Cd Length: 444  Bit Score: 105.35  E-value: 2.18e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  55 LASLAAPMIAVALLQLMMQLISTVMVGHLGEVALAGAAIANSLTNVsGFSVLMGLACGLETICGQAYGAEQYHKLALYMY 134
Cdd:cd13142    13 LLKLAWPIIVSNLLQVAYNLADTFWLGRLGADAVAAPSISWPLIFL-FISLGGGLTVAGTALVAQYTGAGDYDKANKVAG 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 135 RSIIVLLVVSVPIAIIWVFI--PEVLPLIGQQPEIASEVGKYALWLIPGL-FAFTvaqclskFLQTQSL-------IFPM 204
Cdd:cd13142    92 QTFSFVIILSLILAVLGYILsrPLLLLLIGAPEEVYPLALAYLRIIFLGLpFMFI-------FFVFNSLlrgigdtKTPM 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 205 VLsSSITLALFIPLCWFMVYKVG----MGNAGAALSVSICDWVeVTVLGLYIVLSpscEKTRAPLTWEAF----SGIGSF 276
Cdd:cd13142   165 KI-MFGSVLLNVILDPLLIFGIGpfpgLGVAGAALATVISRGI-AAVIGLYLLFK---GRVGLKISLRDLkpdwEWLKKI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 277 LRLAVPSALMICLEwwSYELLVLLSGILPNPALETSVLSICISTVVLVYNLPHGIGTAASVRVSNELGAGNPEGARLVVG 356
Cdd:cd13142   240 FRIGLPSSIEQSAR--ALGFTVMTALVAGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVK 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 357 VALSVILCSAVLVSVTLLALRHFIGIAFSNEEEVINYVTRMVPVLSISVITDSLQGVLSGVSRGCGWQHLGAYVNLGAFY 436
Cdd:cd13142   318 KAALLIFLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILRLW 397

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 1002234851 437 LVGVPVALFFGFAMHLGGMGFWMGMVAGGATQVTLLSIITAMTNWRK 483
Cdd:cd13142   398 VIRIPLAYLLAYVLGLGVTGIWIAMAISNIVAALIALAWFKRGTWKK 444
MATE_MepA_like cd13143
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
 55-461 9.26e-24

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.


Pssm-ID: 240548 [Multi-domain]  Cd Length: 426  Bit Score: 103.36  E-value: 9.26e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  55 LASLAAPMIAVALLQLMMQLISTVMVGHL-GEVALAGAAIANSLTN-VSGFSVLMGLACGleTICGQAYGAEQYHKLALY 132
Cdd:cd13143     6 FLKFALPAIIGMLVNGLYNIVDGIFVGHGvGALALAAVNLVFPIIMlLMALGLMIGVGGA--SLISRRLGAGDREKANRI 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 133 MYRSIIVLLVVS-VPIAIIWVFIPEVLPLIGQQPEIASEVGKYALWLIPGLFAFTVAQCLSKFLQTQSLIFPMVLSSSIT 211
Cdd:cd13143    84 FSTALLLSLILGlLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGMLIG 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 212 LALFIPLCWFMVYKVGMGNAGAALSVSICDWVEVTVLGLYIVLSPSCEKTRAPLTWEAFSGIGSFLRLAVPSALMiclew 291
Cdd:cd13143   164 AVLNIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYFFRGKSLLKLSLLRFKLSLKIIKEILALGFPSFLM----- 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 292 wsyELLVLLSGILPNPALET-------SVLSICISTVVLVYNLPHGIGTAASVRVSNELGAGNPEGARLVVGVALSVILC 364
Cdd:cd13143   239 ---QLSSSVVTIVLNLTLLGyggdigvAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALI 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 365 SAVLVSVTLLALRHFIGIAFSNEEEVINYVTRMVPVLSISVITDSLQGVLSGVSRGCGWQHLGAYVNLGAFYLVGVPVAL 444
Cdd:cd13143   316 YGLVLFLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGLFLIPLLL 395

                         410
                  ....*....|....*..
gi 1002234851 445 FfgFAMHLGGMGFWMGM 461
Cdd:cd13143   396 I--LPRLFGLDGIWLAF 410
MatE pfam01554
MatE; The MatE domain
 282-443 2.32e-22

MatE; The MatE domain


Pssm-ID: 334587 [Multi-domain]  Cd Length: 161  Bit Score: 93.40  E-value: 2.32e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 282 PSALMICLEWWSYELLVLLSGILPnpALETSVLSICISTVVLVYNLPHGIGTAASVRVSNELGAGNPEGARLVVGVALSV 361
Cdd:pfam01554   1 PIALENLLQSLYSLIDTLFVGHLG--AVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLIL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 362 ILCSAVLVSVTLLALRHFIGIAFSNEEEVINYVTRMVPVLSISVITDSLQGVLSGVSRGCGWQHLGAYVNLGAfYLVGVP 441
Cdd:pfam01554  79 GLLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIIS-LLLNIP 157


                  ..
gi 1002234851 442 VA 443
Cdd:pfam01554 158 LN 159
NorM COG0534
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
45-251 4.05e-18

Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];


Pssm-ID: 440300 [Multi-domain]  Cd Length: 427  Bit Score: 86.35  E-value: 4.05e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  45 WREATAEAGRLASLAAPMIAVALLQLMMQLISTVMVGHLGEVALAGAAIANSLTNVSgFSVLMGLACGLETICGQAYGAE 124
Cdd:COG0534   221 LRPDRKILKRILRIGLPAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLA-FMPALGLGQAAQPLVGQNLGAG 299

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 125 QYHKLALYMYRSIIVLLVVSVPIAIIWVFIPEVLP-LIGQQPEIASEVGKYALWLIPGLFAFTVAQCLSKFLQ-TQSLIF 202
Cdd:COG0534   300 DYDRARRAARLALLLALGIGLLLALLLFLFPEPIIgLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRgAGDTRF 379

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1002234851 203 PMVLSSSITLALFIPLCWFMVYkVGMGNAGAALSVSICDWVEVTVLGLY 251
Cdd:COG0534   380 PMIISLLRLWLVRLPLAYLLAF-LGLGLTGVWLALPIGEVLRALLLLLR 427
MATE_like_14 cd13139
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 58-483 5.89e-14

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240544 [Multi-domain]  Cd Length: 448  Bit Score: 73.80  E-value: 5.89e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  58 LAAPMIavalLQLMMQ----LISTVMVGHLGEVALAGAAIANSLTNVSgFSVLMGLACGLETICGQAYGAEQYHKLALYM 133
Cdd:cd13139    19 LAIPMV----LEMVMEslfaVVDLYFVSRLGALAIATVGLTESVLTIV-YSIAIGLSMAATALVARRIGEKDPEGAGFAA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 134 YRSIIVLLVVSVPIAII-WVFIPEVLPLIGQQPEIASEVGKYALWLIPGLFAFTVaqclskfLQTQSLIF-----PMVLS 207
Cdd:cd13139    94 VQAILLGVALSLILSILgYFFAEDILSLMGASPAVIAEGYGYTRIMFGGNGFIML-------LFLINGIFrgagdAAIAM 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 208 SSITLA--LFIPLCWFMVYKVG----MGNAGAALSVSICDWVEV-------TVLGLYIVLSPSCEKTRAPLTWeafsgig 274
Cdd:cd13139   167 RSLWLAngLNIILDPLFIFGLGpipaMGVTGAAIATTIGRSIGVlyqlyhlFKGKGRIQIRRRHLKLDWAIIK------- 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 275 SFLRLAVPSALMICLEWWSYELLVLLSGILPNPALetSVLSICIStVVLVYNLPH-GIGTAASVRVSNELGAGNPEGARL 353
Cdd:cd13139   240 KIIKIAVGGILQFLIASSSWIFLVRIIAEFGSTAL--AGYTIAIR-IIMFALLPAwGLSNAAATLVGQNLGAGQPDRAEK 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 354 VVGVALSVILCSAVLVSVTLLALRHFIGIAFSNEEEVINYVTRMVPVLSISVITDSLQGVLSGVSRGCGWQHLGAYVNLG 433
Cdd:cd13139   317 SVWRAGKYNMVFLGIVSLVFFLFAEPLVSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTLINLV 396

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 1002234851 434 AFYLVGVPVALFFGFAMHLGGMGFWMGMVAGGATQVTLLSIITAMTNWRK 483
Cdd:cd13139   397 GFWLFQIPLAYLLARHLNLGPKGVFIAIPIAETVLAIAAIILFRRGKWKT 446
PRK00187 PRK00187
NorM family multidrug efflux MATE transporter;
46-466 2.10e-12

NorM family multidrug efflux MATE transporter;


Pssm-ID: 166843 [Multi-domain]  Cd Length: 464  Bit Score: 69.00  E-value: 2.10e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  46 REATAEAGRLASLAAPMIAVALLQLMMQLISTVMVGHLGEVALAGAAI-ANSLTNVSGFSVlmGLACGLETICGQAYGAE 124
Cdd:PRK00187    3 VPPTTELKAILRLAGPLIASQLAHMLMVFTDTLMMGRLGPEALAGGGLgAASYSFVSIFCV--GVIAAVGTLVAIRHGAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 125 QYHKLALYMYRSI-IVLLVVSVPIAIIWVFIPeVLPLIGQQPEIASEVGKYALWL---IPGLFAFTVAQCLSKFLQTQSL 200
Cdd:PRK00187   81 DIEGATRLAQAGLwLAWLLALVAALLLWNLKP-LLLLFGQAPQNVDAAMQFLHLLpfaLPGYLSFMALRGFTSALGRAGP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 201 IfpMVLSSSITLALF-----IPLCWFMVYKVGMGNAGAAL-SVSICDWVevtVLGLYIVLSPSCE--KTRAPLTWEAFSG 272
Cdd:PRK00187  160 V--MVISLAGAVANLllnyaLIEGWFGLPKLGLMGIGLVTaLVSNGMAL---ALALYIRRHPAYAayPLRKGLSRPSRAA 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 273 IGSFLRLAVPSALMICLEWWSYELLVLLSGILPNPALETSvlSICISTVVLVYNLPHGIGTAASVRVSNELGAGNPEGAR 352
Cdd:PRK00187  235 LRELWRLGLPIGGTYAVEVGLFTFAALCMGALGSTQLAAH--QIALQIVSVAFMVPVGLSYAVTMRVGQHYGAGRLLEAR 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 353 LV--VGVALSViLCSAVLVSVTLLALRHFIGIAFSNEEEVINYVTRM-VPVLSISV---ITDSLQGVLSGVSRGCGWQHL 426
Cdd:PRK00187  313 RAgrVGIGFGA-VVMLLFAGLFWLLPEAIIGLFLDRNDPAFAEIVQLaVSLLAVAAwfeLFDGTQTIAMGAIRGLKDART 391

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 1002234851 427 GAYVNLGAFYLVGVPVALFFGFAMHLGGMGFWMGMVAGGA 466
Cdd:PRK00187  392 TFLIGLACYWLVGAPLAWLLAFTLGWGAVGVWWGLALGLA 431
MATE_DinF_like cd13136
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ...
 54-463 5.18e-12

DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240541 [Multi-domain]  Cd Length: 424  Bit Score: 67.59  E-value: 5.18e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  54 RLASLAAPMIAVALLQLMMQLISTVMVGHLGEVA-LAGAAIANSLTNVSgFSVLMGLACGLETICGQAYGAEQYHKLALY 132
Cdd:cd13136     4 EILALALPAILSNITVPLLGLVDTAVVGHLGSAAyLGAVALGTTIFNTL-FWLFGFLRMGTTGLVAQALGAGDREEAIAL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 133 MYRSIIVLLVVSVPIAIIWV-FIPEVLPLIGQQPEIASEVGKYALWLIPGL-FAFTVAQCLSKFLQTQSLIFPMVLsSSI 210
Cdd:cd13136    83 LVRALLLALAIGLLLILLQSpLLALALLLLGASAAVAALARQYLRIRILGApAVLLNYVATGWFRGLQDTRTPLIL-QIV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 211 TLALFIPLCWFMVYKVGMGNAGAALSVSICDWVEVTVLGLYIVLSPSCEKTRAPLTWEAFSGIGSFLRLAVPSAL-MICL 289
Cdd:cd13136   162 GNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGLWLLRRRVRLLGKSLSRRLPSKAALKRLFKLNRDIFIrTLAL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 290 ewwsyeLLVLLSGILPNPALETSVLS---ICISTVVLVYNLPHGIGTAASVRVSNELGAGNPEGARLVVGVALSVILCSA 366
Cdd:cd13136   242 ------LAAFLFFTALAARLGDVILAanqILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQWGLGLG 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 367 VLVSVTLLALRHFIGIAFSNEEEVINYVTRMVPVLSISVITDSLQGVLSGVSRGCGWqhlGAYVNLGAFYLVGVPVALFF 446
Cdd:cd13136   316 VLLALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATD---TRYLRNSMLVSLAVFLPLLF 392

                         410
                  ....*....|....*..
gi 1002234851 447 GFAMHLGGMGFWMGMVA 463
Cdd:cd13136   393 LLVPLWGNHGLWLALIL 409
MATE_like_9 cd13135
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 58-475 6.79e-11

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240540 [Multi-domain]  Cd Length: 429  Bit Score: 64.24  E-value: 6.79e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  58 LAAPMIAVALLQLMMQLISTVMVGHLGEVALAGAAIANSLTNvSGFSVLMGLACGLETICGQAYGAEQYHKLALYMYRSI 137
Cdd:cd13135     6 IAIPLILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVTTPFN-TITGFLGSISIGFTILGSQSVGAKDIKRINDYAISSI 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 138 IVLLVVSVPIAIIWVFIPEVL-PLIGQQPEIASEVGKY----ALWLIPGLFAFTvaqcLSKFLQTQSLIFPMVLSSSITL 212
Cdd:cd13135    85 VYNSIIGVILFLLWLFGARIIfVLFGVDGQILGYSINYvrifSIYLLLLGILFT----FSSILQGIGETKPIMYGGIIKN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 213 ALFIPLCWFMVY-KVG---MGNAGAALSVSIcdwVEVTVLGLYIVLspsCEKTR--------APLTWEAFSGIGSFLRLA 280
Cdd:cd13135   161 LLNVILDYVLIFgNFGfprLGIIGAAIATTI---ANVLNLIILVYL---CRKIKkltfklsnTKVLKANIRPYKFTIKLG 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 281 VPSALMICLeWWSYELLV--LLSGIlpnPALETSVLSICISTVVLVYNLPHGIGTAASVRVSNELGAGNPEGARLVVGVA 358
Cdd:cd13135   235 LPLGGEEFL-WNIGNLAVirILNRI---GELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNIC 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 359 LSVILCSAVLVSVTLLALRHFIGIAFSNEEEVINYVTRMVPVLSISVITDSLQGVLSGVSRGCGWQHLGAYVNLGAFYLV 438
Cdd:cd13135   311 LGLGLLIYIAAAIVFLAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGDTKWMLYTQIIGTIIV 390

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1002234851 439 gVPVALFFGFAMHLGGMGFWMGMVAGgatqVTLLSII 475
Cdd:cd13135   391 -VSVALLLIFVFKLGLAGVYITLFID----EIIRAII 422
MATE_like_8 cd13134
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 71-243 4.15e-10

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240539 [Multi-domain]  Cd Length: 438  Bit Score: 61.75  E-value: 4.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  71 MMQLISTVMVGHLGEVALAGAAIANSLTNVSgFSVLMGLACGLETICGQAYGAEQYHKLALYMYRSIIVLLVVSVPIA-I 149
Cdd:cd13134   246 LSQTVITAFIARLGTAALAARTYASNISMFV-FLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGLLVSLAVAlL 324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 150 IWVFIPEVLPLIGQQPEIAsEVGKYALW----LIPG-LFAFTVAQCLSKflqTQSLIFPMVLSSSITLALFIPLCWFMVY 224
Cdd:cd13134   325 LALFREPILGLFTDDPEII-ALGKTLLLisilLEPGrAFNIVLIGSLRA---AGDARFPVLIGIISMWGISVPLAYLLGI 400

                         170
                  ....*....|....*....
gi 1002234851 225 KVGMGNAGAALSVSICDWV 243
Cdd:cd13134   401 VLGLGLLGVWIAFAADEWV 419
MATE_NorM_like cd13137
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
 44-239 1.44e-09

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240542 [Multi-domain]  Cd Length: 432  Bit Score: 59.83  E-value: 1.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  44 WWREATAEAGRLASLAAPMIAVALLQLMMQLISTVMVGHLGEVALAGAAIANSLTNVSgFSVLMGLACGLETICGQAYGA 123
Cdd:cd13137   217 GFRLDRKIIKKLLRIGLPAGLEQLLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLA-FMPGFGFSMAASTLVGQNLGA 295

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 124 EQYHKLALYMYRSI-IVLLVVSVPIAIIWVFIPEVLPLIGQQPEIASEVGKYALWLIPGLFAFTVAQCLSKFLQTQSLIF 202
Cdd:cd13137   296 GDPDEARRYGKRALrLGVLFMGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTR 375

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1002234851 203 PMVLSSSITLALF-IPLCWFMVYKVGMGNAGAALSVSI 239
Cdd:cd13137   376 PPLIINLISMWLVrLPLAYLLGFVLGLGLTGIWLAMFV 413
MATE_like_4 cd13144
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 55-447 1.64e-09

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240549 [Multi-domain]  Cd Length: 434  Bit Score: 59.94  E-value: 1.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  55 LASLAAPMIAVALLQLMMQLISTVMVGHLGEVALAGAAIANSLTNVSgFSVLMGLACGLETICGQAYGAEQYHKLALYMY 134
Cdd:cd13144    10 LLTMSIPAMISMLFQALYNIVDSIFVARLGENALTAVSLAFPIQNLM-IAVAVGTGVGVNALLSRSLGEKDQKEANKAAN 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 135 RSIIVLLVVSVPIAIIWVF-IPEVLPLIGQQPEIASEVGKYALWLIPGLFAFTVAQCLSKFLQTQS-LIFPM---VLSSS 209
Cdd:cd13144    89 NGLLLALLSYLLFLLLGLFgVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGnTITPMiaqLIGAI 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 210 ITLALFIPLCWFMVYKVGMGNAGAALSVSIcDWVEVTVLGLYIVL------SPSCEKTRapLTWEAfsgIGSFLRLAVPS 283
Cdd:cd13144   169 INIILDPILIFGLFGFPAMGIAGAAIATVI-GQILAMFLAFFFLLrknkdvQPDLRLFR--PSLRI---IKEIYAVGLPS 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 284 ALMICLewwSYELLVLLSGIL-PNPALETSVLSICISTVVLVYNLPHGIGTAASVRVSNELGAGNPEgaRLVVGVALSVI 362
Cdd:cd13144   243 IIMQAI---SSVMVFGLNKILaGFGPTAVAVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKD--RIREAIKYAIL 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 363 LCSAVLVSVTLL--ALRHFIGIAFSNEEEVINYVTRMVPVLSISVITDSLQGVLSGVSRGCGWQHLGAYVNLGAFYLVGV 440
Cdd:cd13144   318 IAVVIMLAGGLLfqLFPDQLLGLFNASEEMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYSLIISVARQLVVLL 397


                  ....*..
gi 1002234851 441 PVALFFG 447
Cdd:cd13144   398 PLAWLLA 404
MATE_like_1 cd13140
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 52-419 1.17e-08

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240545 [Multi-domain]  Cd Length: 435  Bit Score: 57.15  E-value: 1.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  52 AGRLASLAAPMIAVALLQLMMQLISTVMVGHLGEVALAGAAIANSLTNVSgFSVLMGLACGLETICGQAYGAEQYHKLAL 131
Cdd:cd13140     4 LKTLLRLALPIMGTSFIQMAYNLTDMFWVGRLGSDAVAAVGTAGFFVWLA-YALALLSKIGAQVKVSQSIGAKDEKEARK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 132 YMYRSIIVLLVVSVPIAIIWVFIPEvlPLIG----QQPEIASEVGKY---ALWLIPGLFAFTV------AQCLSKF---L 195
Cdd:cd13140    83 YARNALQLNLLLGILYGLLLLLFAK--PLIGffnlGDAEVISLAITYlriVALGLIFSFLNPVftgifnALGDSKTpfiI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 196 QTQSLIFPMVLSssitlalfiPLCWF-MVYKVGMGNAGAALSVSICDWVeVTVLGLYIV----LSPSCEKTRAPLTWEAF 270
Cdd:cd13140   161 NAIGLVLNIILD---------PLLIFgFGPFPALGVAGAALATVLAQAI-VFLLFLYALkkkkGLFLKIRILKRPDRKYI 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 271 SGIgsfLRLAVPSALMICL-EWWSYELLVLLSGILPNPaleTSVLSICISTVVLVYNLPHGIGTAASVRVSNELGAGNPE 349
Cdd:cd13140   231 KEI---LKLGLPVALQSILfALISMILARIIASFGPVA---IAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYD 304

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1002234851 350 GARLVVGVALSVILCSAVLVSVTLLALRHFIGIAFSNEEEVINYVTRMVPVLSISVITDSL----QGVLSGVSR 419
Cdd:cd13140   305 RIRKGYKTALKIASAIGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRILGFSQLFMCLeittTGAFNGLGR 378
MATE_like_6 cd13146
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 55-473 1.27e-08

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240551 [Multi-domain]  Cd Length: 433  Bit Score: 57.03  E-value: 1.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  55 LASLAAPMIAVALLQLMMQLISTVMVGHL--GEVALAGAAIANSLTNVSGFSVLMGLACGLETICGQAYGAEQYHKL-AL 131
Cdd:cd13146    10 LIRLALPILIGQLFQLLYNITDTIWISMIdpSDPALVGGIGLVFPLGMIFLALGNGIQVGVSSLLARAIGAQRAKELdQA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 132 YMYRSIIVLLVVSVPIAIIWVFIPEVLPLIGQQPEIASEVGKYALWLIPGLFAFTVAQCLSKFLQTQSLIFPMVLSSSIT 211
Cdd:cd13146    90 ADSGLALALLAATVIVVLGYIFAEPLLQLLGAKGLLLEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTKYMMMAMLIG 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 212 LALFIPLCWFMVYKVGMGNAGAALSVSICDWVEVtvlgLYIVLSPSCEKTRAPLTWeAFSGIGS-----FLRLAVPSALM 286
Cdd:cd13146   170 TVVNIVLDPILIFVFDMGVKGAALATVLAQAISL----LYLLYVFLIGKSNVTIHI-KLSNISSsviveILRVGLPQMLL 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 287 ICLEWWSYELLVLLSGILPNPALETSVLSICISTVVLVYNLphGIGTAASVRVSNELGAGNPEGAR--LVVGVALSVILC 364
Cdd:cd13146   245 QLISSISFLIYNRIIIDIDPVAMTAFTLVGRLDQFILIPIF--AISSALLTIAGQNWGRGNYDRMLqiLMTAVILGIVVV 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 365 SAVLVSVTLLALRHFigIAFSNEEEVINYVTRMVPVLSISVITDSLQGVLSGVSRGCGWQHLGAYVNLGAFYLVGVPVAL 444
Cdd:cd13146   323 LVLVLGYVLVAPWLF--SLFTTVPEVVAYAVLQVRTMALALPFVAISILVTEFFQAIGKAWPSLLLTLIRHVFLSVPVVY 400

                         410       420
                  ....*....|....*....|....*....
gi 1002234851 445 FFGFAMHLGGMGFWMGMVagGATQVTLLS 473
Cdd:cd13146   401 LLAYVFGKGITGVYFGIV--SANFFTALL 427
MATE_DinF_like cd13136
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ...
 50-180 1.46e-07

DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240541 [Multi-domain]  Cd Length: 424  Bit Score: 53.72  E-value: 1.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  50 AEAGRLASLAAPMIAVALLQLMMQLISTVMVGHLGEVALAGAAIANSLTNVSGFsVLMGLACGLETICGQAYGAEQYHKL 129
Cdd:cd13136   222 AALKRLFKLNRDIFIRTLALLAAFLFFTALAARLGDVILAANQILLQFWLLSSY-FLDGFAYAAEALVGRALGAGDRKAA 300

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1002234851 130 ALYMYRSIIVLLVVSVPIAIIWVFIPEVLP-LIGQQPEIASEVGKYALWLIP 180
Cdd:cd13136   301 RRVARRLLQWGLGLGVLLALLFFLGGEPIIrLFTDDPAVLALAATYLPWLAL 352
MATE_like_13 cd13141
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 55-252 3.66e-07

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240546 [Multi-domain]  Cd Length: 443  Bit Score: 52.32  E-value: 3.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  55 LASLAAPMIAVALLQLMMQLISTVMVGHLGEVALAGAAIANSLTNVSgFSVLMGLACGLETICGQAYGA-EQYHKLALY- 132
Cdd:cd13141    13 IISMALPIAIGMIIQTLYFLVDLYFVGQLGDAALAGVSLAGNVMFFV-MALTQVLNVGTAALVSHAVGRkDQGEANAVFn 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 133 --MYRSIIVLLVVSVpiaIIWVFIPEVLPLIGQQPEIASEVGKYALWLIPGL---FAFTVaqcLSKFLQTQSLIFPMVLS 207
Cdd:cd13141    92 qsLLLAAVLGLVVLV---LGYLFGRLYLETLAADAATVEAATTYLYWFIPSLalqFILTV---LGAALRGTGIVKPFMVI 165

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1002234851 208 SSITLALFIPLCWFMVYKVG----MGNAGAALSVSICDWVEVTVLGLYI 252
Cdd:cd13141   166 QILAVLLNIILAPILITGWGtgraLGVAGAGLASSISVAIAVVLLLYYF 214
MATE_like_2 cd13149
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 55-449 2.04e-06

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240554 [Multi-domain]  Cd Length: 434  Bit Score: 49.99  E-value: 2.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  55 LASLAAPMIAVALLQLMMQLISTVMVGHLGEVALAGAAIANSLTNVSGfSVLMGLACGLETICGQAYGAEQYHKLALYMY 134
Cdd:cd13149    11 LIKLTLPMIFGILAMLIFNLTDTFFVGKLGTKELAAISFTFPVVLFLN-SLTIGLGIGASAVISRAIGAGDRNKAKRLAT 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 135 RSIIVLLVVSVPIAII-WVFIPEVLPLIGQQPEIASEVGKY-ALWLIPGLFA---FTVAQCLSKFLQTQSLIFPMVLSSS 209
Cdd:cd13149    90 DSLILSLLLSVIVSLLgLFTIPPLFSLLGASGEILPLIVEYmAIWYLGLVFLvlpMVGNAIIRATGDTKRPSLVMLGAAL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 210 ITLALfIPLCWFMVYKV-GMGNAGAALSVSIcDWVEVTVLGLYIVLSP----SCEKTRAPLTWEAFSGIgsfLRLAVPSA 284
Cdd:cd13149   170 VNVIL-DPILIFGFGPIpGMGIAGAAIATVI-SRALGLGAALYFLHYHhrliDFSEPSLKALFRSWKDI---LSIGIPAA 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 285 LMICLEWWSYELLVLLSGILPNPALETSVLSICISTVVLVynLPHGIGTAASVRVSNELGAGNPEGARLVVGVALSVILC 364
Cdd:cd13149   245 LSNILTPLSAAFITALVATYGPAAVAAFGVATRIESFAFI--IVMALSSALGPFVGQNWGAGQYERVQEGLKISLKFSLI 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 365 SAVLVSVTLLALRHFIGIAFSNEEEVINYVTRMVPVLSISVITDSLQGVLSGVSRGCGWQHLGAYVNLGAFYLVGVPVA- 443
Cdd:cd13149   323 YGAILGIVLALFAGWLASLFSAEPEVIELITLYLLIVPIGYGGLGILIITSASFNALGKPLYSLGLNLIRVFLLYIPLAy 402


                  ....*....
gi 1002234851 444 ---LFFGFA 449
Cdd:cd13149   403 vgsHLLGFA 411
MATE_MJ0709_like cd13147
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ...
 58-466 2.72e-06

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240552 [Multi-domain]  Cd Length: 441  Bit Score: 49.85  E-value: 2.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  58 LAAPMIAVALLQLMMQLISTVMVGHLGEVALAGAAIANSLtnvsgFSVLMGLACGL----ETICGQAYGAEQYHKLALYM 133
Cdd:cd13147    14 LSIPMIIAMLLQTLYNLVDAIWVAGLGADALAAIGFVFPL-----FMIIIGLGNGLgagaSSAISRRIGAKDKEGADNAA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 134 YRSIIVLLVVSVPIAIIW-VFIPEVLPLIGQQpEIASEVGKYALWLIPGLFAFTVAQCLSKFLQ----TQSLIFPMVLSS 208
Cdd:cd13147    89 VHSILLGLIISIILTIVLlPFLEPILVLMGAG-EVLDLAVDYGRIIFLGSIFLIFNNVAYGILRgegdTKRAMYAMVAGS 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 209 SITLAL---FIplcwfmvYKVGMGNAGAALSVSICDWVEVTVLGL--------YIVLSPSCEKTRAPLTWEAFS-GIGSF 276
Cdd:cd13147   168 ILNIILdpiFI-------YTLGLGIAGAAWATVISMLISSLVLLYwffvkkdtYVSLSLKNFKFDKKIVKDILKvGIPAS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 277 LRLAVPSALMICLEWwsyeLLVLLSGILpNPALETSVLSIcistvVLVYNLP-HGIGTAASVRVSNELGAGNPEGARLVV 355
Cdd:cd13147   241 LEQLIMSVLMIILNL----ILVIVAGTD-GVAVYTAGWRI-----VSFAIIPlIGIATAVTSVTGAAYGARNYEKLKTAY 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 356 GVALSVILCSAVLVSVTLLALRHFIGIAFSNEEEVINYVTRMVPVLSISVITdsLQGVLSGVSRGCGWQHLGAYVN---- 431
Cdd:cd13147   311 NYSIKLGLIIELIIAILIFIFAPQIAYLFTYSEESAHLAPEIVAFLRIMCLF--LPFVPFGMMSSSMFQGIGKGLTslii 388

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1002234851 432 --LGAFYLVgVPVALFFGFAMHLGGMGFWMGMVAGGA 466
Cdd:cd13147   389 tiLRELIFQ-VLFAYLFAIVLGLGLFGVWWGIVLGNA 424
matE TIGR00797
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ...
 53-179 5.96e-06

putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]


Pssm-ID: 273273 [Multi-domain]  Cd Length: 342  Bit Score: 48.40  E-value: 5.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  53 GRLASLAAPMIAVALLQLMMQLISTVMVGHLGEVALAGAAIANSLTNVSgFSVLMGLACGLETICGQAYGAEQYHKLALY 132
Cdd:TIGR00797 216 KRLLKLGLPIAFRVILESLSFALLALLVARLGSIALAAHQIALNVESLL-FMPAFGFGIAVSILVGQALGAGDPKRAKEV 294

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1002234851 133 MYRSIIVLLVVSVPIAIIWVFIPEVLP-LIGQQPEIASEVGKYALWLI 179
Cdd:TIGR00797 295 ARVALKLSLLLGLVLAIILILFREFIArLFTNDPEVLELAAIYLIFVA 342
RfbX COG2244
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ...
 53-240 5.01e-04

Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441845 [Multi-domain]  Cd Length: 366  Bit Score: 42.24  E-value: 5.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  53 GRLASLAAPMIAVALLQLMMQLISTVMVGH-LGEVALAGAAIANSLTNVSGFsVLMGLACGLETICGQAYGAEQYHKLAL 131
Cdd:COG2244   173 GLVLKYSLPLLLSGLLGLLLTNLDRLLLGAlLGPAAVGIYSAAYRLASLLLL-LITALSQVLFPRLSRLLAEGDREELRR 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 132 YMYRSIIVLLVVSVPIAI-IWVFIPEVLPLIGqqPEIASEVGKYALWLIPGLFAFTVAQCLSKFLQTQSLIFPMVLSSSI 210
Cdd:COG2244   252 LYRKALRLLLLLGLPLALgLALLAPPLLSLLF--GPEYAEAAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLI 329

                         170       180       190
                  ....*....|....*....|....*....|
gi 1002234851 211 TLALFIPLCWFMVYKVGMgnAGAALSVSIC 240
Cdd:COG2244   330 GAVLNLVLNLLLIPRYGL--VGAAIATLLS 357
MATE_like_2 cd13149
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 54-220 6.21e-04

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240554 [Multi-domain]  Cd Length: 434  Bit Score: 42.29  E-value: 6.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  54 RLASLAAP-MIAVALLQLMMQLIsTVMVGHLGEVALAGAAIANSLTNVSgFSVLMGLACGLETICGQAYGAEQYHKLALY 132
Cdd:cd13149   235 DILSIGIPaALSNILTPLSAAFI-TALVATYGPAAVAAFGVATRIESFA-FIIVMALSSALGPFVGQNWGAGQYERVQEG 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 133 MYRSIIVLLVVSVPIAIIW-VFIPEVLPLIGQQPEIASEVGKYALWLIPGLFAFTVAQCLSK-FLQTQSLIFPMVLSSSI 210
Cdd:cd13149   313 LKISLKFSLIYGAILGIVLaLFAGWLASLFSAEPEVIELITLYLLIVPIGYGGLGILIITSAsFNALGKPLYSLGLNLIR 392

                         170
                  ....*....|
gi 1002234851 211 TLALFIPLCW 220
Cdd:cd13149   393 VFLLYIPLAY 402
MATE_like_3 cd13148
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 55-376 8.68e-04

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240553 [Multi-domain]  Cd Length: 441  Bit Score: 41.87  E-value: 8.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851  55 LASLAAPMIAVALLQLMMQLISTVMVGHLGEVALAGAAIAnsltnvsgFSVLM--------GLACGLETICGQAYGAEQY 126
Cdd:cd13148    14 LLRLALPNILALLVQTLVGLAETYFVGQLGTDALAGVALV--------FPLLMltqmmsngAMGGGVSSAIARALGAGDR 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 127 HKLALYMYRSIIVLLVVSVPIAII-WVFIPEVLPLIGQQPEIASEVGKYALWLIPGLFAFTVAQCLSKFLQ-TQSLIFP- 203
Cdd:cd13148    86 ERAEALVWHALVIALAGGLVFSLLfLLFGPALYRLLGGRGEALDAALAYSNVLFSGAILIWLVNLLAAALRgTGNMRVPa 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 204 --MVLSSSITLAL--FIPLCWFMVYKVGMgnAGAALSVSICDWVEVTVLGLYIvLSPSC----EKTRAPLTWEAFSGIgs 275
Cdd:cd13148   166 lvTLVGAVVQIPLspGLILGWGPLPRLGV--AGAAVAAVLYYALAALVLLRYL-ASGRSrlrlRLRALRLERRLFRDI-- 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002234851 276 fLRLAVPSALMICLEWWSYELLVLLSGILPNPALE----TSVLSICISTVVLvynlphGIGTAASVRVSNELGAGNPEGA 351
Cdd:cd13148   241 -LRVGLLAALSPLQTNLTVLLLTGLVGRFGTAALAgygiGSRLEFLLIPLVF------GLGAAMTAMVGMNIGAGQIARA 313

                         330       340
                  ....*....|....*....|....*
gi 1002234851 352 RlvvGVALSVILCSAVLVSVTLLAL 376
Cdd:cd13148   314 R---RIAWTGALMAAVLAGAIGLVL 335
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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