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Conserved domains on  [gi|1002237113|ref|XP_015622762|]
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isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial isoform X2 [Oryza sativa Japonica Group]

Protein Classification

isocitrate dehydrogenase( domain architecture ID 10010648)

isocitrate dehydrogenase catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate and CO2 in an NAD-dependent manner or NADP-dependent manner

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 28-374 0e+00

isocitrate dehydrogenase (NAD+)


:

Pssm-ID: 215065  Cd Length: 360  Bit Score: 727.04  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113  28 AAAAVSRRTVTYMPRPGDGAPRAVTLIPGDGIGPLVTGAVRQVMEAMHAPVYFESYEVRGDMPTVPPEVIDSIRRNKVCL 107
Cdd:PLN00123   10 LGSKAQRRSVTYMPRPGDGAPRAVTLIPGDGIGPLVTGAVEQVMEAMHAPVYFERYEVHGDMKKVPEEVLESIRRNKVCL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 108 KGGLATPVGGGVSSLNVQLRKELDLYASLVNCFNLPGLPTRHDNVDIVVIRENTEGEYSGLEHEVVPGVVESLK----FC 183
Cdd:PLN00123   90 KGGLATPVGGGVSSLNVQLRKELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEGEYSGLEHEVVPGVVESLKvitkFC 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 184 SERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLY 263
Cdd:PLN00123  170 SERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQFDVMVTPNLY 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 264 GNLVANTAAGIAGGTGVMPGGNVGQDHAVFEQGASAGNVGNVKVVEQKKANPVALLLSSAMMLRHLQFPSFADRLETAVK 343
Cdd:PLN00123  250 GNLVANTAAGIAGGTGVMPGGNVGADHAVFEQGASAGNVGNEKLVEQKKANPVALLLSSAMMLRHLQFPSFADRLETAVK 329

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1002237113 344 RVIAEGKYRTKDLGGSSTTQEVTDAVIAHLD 374
Cdd:PLN00123  330 RVIAEGKYRTKDLGGSSTTQEVVDAVIANLD 360
 
Name Accession Description Interval E-value
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 28-374 0e+00

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 727.04  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113  28 AAAAVSRRTVTYMPRPGDGAPRAVTLIPGDGIGPLVTGAVRQVMEAMHAPVYFESYEVRGDMPTVPPEVIDSIRRNKVCL 107
Cdd:PLN00123   10 LGSKAQRRSVTYMPRPGDGAPRAVTLIPGDGIGPLVTGAVEQVMEAMHAPVYFERYEVHGDMKKVPEEVLESIRRNKVCL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 108 KGGLATPVGGGVSSLNVQLRKELDLYASLVNCFNLPGLPTRHDNVDIVVIRENTEGEYSGLEHEVVPGVVESLK----FC 183
Cdd:PLN00123   90 KGGLATPVGGGVSSLNVQLRKELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEGEYSGLEHEVVPGVVESLKvitkFC 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 184 SERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLY 263
Cdd:PLN00123  170 SERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQFDVMVTPNLY 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 264 GNLVANTAAGIAGGTGVMPGGNVGQDHAVFEQGASAGNVGNVKVVEQKKANPVALLLSSAMMLRHLQFPSFADRLETAVK 343
Cdd:PLN00123  250 GNLVANTAAGIAGGTGVMPGGNVGADHAVFEQGASAGNVGNEKLVEQKKANPVALLLSSAMMLRHLQFPSFADRLETAVK 329

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1002237113 344 RVIAEGKYRTKDLGGSSTTQEVTDAVIAHLD 374
Cdd:PLN00123  330 RVIAEGKYRTKDLGGSSTTQEVVDAVIANLD 360
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 46-373 0e+00

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 550.06  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113  46 GAPRAVTLIPGDGIGPLVTGAVRQVMEAMHAPVYFESYEVRGDMP---TVPPEVIDSIRRNKVCLKGGLATPVG-GGVSS 121
Cdd:TIGR00175   1 GGKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPQTDgktEIPDEAVESIKRNKVALKGPLETPIGkGGHRS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 122 LNVQLRKELDLYASLVNCFNLPGLPTRHDNVDIVVIRENTEGEYSGLEHEVVPGVVESLK----FCSERIAKYAFEYAYL 197
Cdd:TIGR00175  81 LNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKvitrDKSERIARYAFEYARK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 198 NNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVANTAAGIAGG 277
Cdd:TIGR00175 161 NGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVGG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 278 TGVMPGGNVGQDHAVFEQGASAgnvGNVKVVEQKKANPVALLLSSAMMLRHLQFPSFADRLETAVKRVIAEGKYRTKDLG 357
Cdd:TIGR00175 241 PGLVPGANIGRDYAVFEPGVRH---TGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLG 317

                         330
                  ....*....|....*.
gi 1002237113 358 GSSTTQEVTDAVIAHL 373
Cdd:TIGR00175 318 GTATTSDFTEAVIKRL 333
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 51-373 3.11e-130

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 376.66  E-value: 3.11e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113  51 VTLIPGDGIGPLVTGAVRQVMEAM-----------HAPVYFESYEVRGDMptVPPEVIDSIRRNKVCLKGGLATPV---G 116
Cdd:COG0473     4 IAVLPGDGIGPEVVAAALKVLEAAaerfgldfefeEADIGGAAYDKTGTP--LPDETLEALRKADAILLGAVGGPKwddG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 117 GGVSSLNVQLRKELDLYASLVNCFNLPGLPTRH-----DNVDIVVIRENTEGEYSGLEHEVVPG----VVESLK----FC 183
Cdd:COG0473    82 VRPESGLLALRKELDLYANLRPAKLYPGLPSPLkpeivEGIDLVIVRENTEGLYFGIGGRIGTGtgeeVAIDTRvytrKG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 184 SERIAKYAFEYAyLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLY 263
Cdd:COG0473   162 IERIARYAFELA-RKRRKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIVTENLF 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 264 GNLVANTAAGIAGGTGVMPGGNVGQDH-AVFE-QGASA----GnvgnvkvveQKKANPVALLLSSAMMLRHLQFPSFADR 337
Cdd:COG0473   241 GDILSDLAAGLTGSLGLAPSANIGDEGkALFEpVHGSApdiaG---------KGIANPIATILSAAMMLRHLGEEEAADA 311

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1002237113 338 LETAVKRVIAEGkYRTKDLGGSSTTQEVTDAVIAHL 373
Cdd:COG0473   312 IEAAVEKVLAEG-VRTPDLGGKAGTSEMGDAIIAAL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
51-369 3.70e-99

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 297.67  E-value: 3.70e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113  51 VTLIPGDGIGPLVTGAVRQVMEAMHAPVYFE-SYEVR----------GDMptVPPEVIDSIRRNKVCLKGGLATPVG--G 117
Cdd:pfam00180   2 IAVLPGDGIGPEVMAAALKVLKAALEKAPLEfEFEERdvggaaidetGEP--LPDETLEACKKADAVLLGAVGGPKWdpA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 118 GVSSLN--VQLRKELDLYASLVNCFNLPGL----PTRHD--NVDIVVIRENTEGEYSGLEHEVVPG---VVESLKFCS-- 184
Cdd:pfam00180  80 GVRPENglLALRKELGLFANLRPAKVFPPLgdasPLKNEveGVDIVIVRELTGGIYFGIEKGIKGSgneVAVDTKLYSrd 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 185 --ERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNL 262
Cdd:pfam00180 160 eiERIARVAFELARKRGRKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPNL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 263 YGNLVANTAAGIAGGTGVMPGGNVGQD-HAVFEqgASAGNVgnVKVVEQKKANPVALLLSSAMMLRH-LQFPSFADRLET 340
Cdd:pfam00180 240 FGDILSDEASMLTGSLGLLPSASLGANgFGIFE--PVHGSA--PDIAGKGIANPIATILSAAMMLRYsLGLEDAADKIEA 315

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1002237113 341 AVKRVIAEGkYRTKDLGGSST---TQEVTDAV 369
Cdd:pfam00180 316 AVLKVLESG-IRTGDLAGSATyvsTSEFGEAV 346
 
Name Accession Description Interval E-value
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 28-374 0e+00

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 727.04  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113  28 AAAAVSRRTVTYMPRPGDGAPRAVTLIPGDGIGPLVTGAVRQVMEAMHAPVYFESYEVRGDMPTVPPEVIDSIRRNKVCL 107
Cdd:PLN00123   10 LGSKAQRRSVTYMPRPGDGAPRAVTLIPGDGIGPLVTGAVEQVMEAMHAPVYFERYEVHGDMKKVPEEVLESIRRNKVCL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 108 KGGLATPVGGGVSSLNVQLRKELDLYASLVNCFNLPGLPTRHDNVDIVVIRENTEGEYSGLEHEVVPGVVESLK----FC 183
Cdd:PLN00123   90 KGGLATPVGGGVSSLNVQLRKELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEGEYSGLEHEVVPGVVESLKvitkFC 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 184 SERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLY 263
Cdd:PLN00123  170 SERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQFDVMVTPNLY 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 264 GNLVANTAAGIAGGTGVMPGGNVGQDHAVFEQGASAGNVGNVKVVEQKKANPVALLLSSAMMLRHLQFPSFADRLETAVK 343
Cdd:PLN00123  250 GNLVANTAAGIAGGTGVMPGGNVGADHAVFEQGASAGNVGNEKLVEQKKANPVALLLSSAMMLRHLQFPSFADRLETAVK 329

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1002237113 344 RVIAEGKYRTKDLGGSSTTQEVTDAVIAHLD 374
Cdd:PLN00123  330 RVIAEGKYRTKDLGGSSTTQEVVDAVIANLD 360
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 46-373 0e+00

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 550.06  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113  46 GAPRAVTLIPGDGIGPLVTGAVRQVMEAMHAPVYFESYEVRGDMP---TVPPEVIDSIRRNKVCLKGGLATPVG-GGVSS 121
Cdd:TIGR00175   1 GGKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPQTDgktEIPDEAVESIKRNKVALKGPLETPIGkGGHRS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 122 LNVQLRKELDLYASLVNCFNLPGLPTRHDNVDIVVIRENTEGEYSGLEHEVVPGVVESLK----FCSERIAKYAFEYAYL 197
Cdd:TIGR00175  81 LNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKvitrDKSERIARYAFEYARK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 198 NNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVANTAAGIAGG 277
Cdd:TIGR00175 161 NGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVGG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 278 TGVMPGGNVGQDHAVFEQGASAgnvGNVKVVEQKKANPVALLLSSAMMLRHLQFPSFADRLETAVKRVIAEGKYRTKDLG 357
Cdd:TIGR00175 241 PGLVPGANIGRDYAVFEPGVRH---TGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLG 317

                         330
                  ....*....|....*.
gi 1002237113 358 GSSTTQEVTDAVIAHL 373
Cdd:TIGR00175 318 GTATTSDFTEAVIKRL 333
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 4-373 4.72e-136

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 392.71  E-value: 4.72e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113   4 RSAPLLQRLLSPTPSPSPSPPHPLA-AAAVSRRTVTYmprpgDGAPRAVTLIPGDGIGPLVTGAVRQVMEAMHAPVYFES 82
Cdd:PLN00118    1 MAAQLLRRLLGNRLAQILGASSSSSgAFSSSARAFSS-----SSTPITATLFPGDGIGPEIAESVKQVFTAAGVPIEWEE 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113  83 YEVrGDmpTVPP--------EVIDSIRRNKVCLKGGLATPVGGGVSSLNVQLRKELDLYASLVNCFNLPGLPTRHDNVDI 154
Cdd:PLN00118   76 HYV-GT--TVDPrtgsfltwESLESVRRNKVGLKGPMATPIGKGHRSLNLTLRKELGLYANVRPCYSLPGYKTRYDDVDL 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 155 VVIRENTEGEYSGLEHEVVPGVVESLKF----CSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVATKY 230
Cdd:PLN00118  153 VTIRENTEGEYSGLEHQVVRGVVESLKIitrqASLRVAEYAFHYAKTHGRKRVSAIHKANIMKKTDGLFLKCCREVAEKY 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 231 PGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVANTAAGIAGGTGVMPGGNVGQDHAVFeqgASAGNVGNVKVVEQ 310
Cdd:PLN00118  233 PEIVYEEVIIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLIGGLGLTPSCNIGENGLAL---AEAVHGSAPDIAGK 309

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1002237113 311 KKANPVALLLSSAMMLRHLQFPSFADRLETAVKRVIAEGKYRTKDLGGSSTTQEVTDAVIAHL 373
Cdd:PLN00118  310 NLANPTALLLSAVMMLRHLKLNEQAEQIHNAILNTIAEGKYRTADLGGSSTTTDFTKAICDHL 372
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 51-373 3.11e-130

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 376.66  E-value: 3.11e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113  51 VTLIPGDGIGPLVTGAVRQVMEAM-----------HAPVYFESYEVRGDMptVPPEVIDSIRRNKVCLKGGLATPV---G 116
Cdd:COG0473     4 IAVLPGDGIGPEVVAAALKVLEAAaerfgldfefeEADIGGAAYDKTGTP--LPDETLEALRKADAILLGAVGGPKwddG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 117 GGVSSLNVQLRKELDLYASLVNCFNLPGLPTRH-----DNVDIVVIRENTEGEYSGLEHEVVPG----VVESLK----FC 183
Cdd:COG0473    82 VRPESGLLALRKELDLYANLRPAKLYPGLPSPLkpeivEGIDLVIVRENTEGLYFGIGGRIGTGtgeeVAIDTRvytrKG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 184 SERIAKYAFEYAyLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLY 263
Cdd:COG0473   162 IERIARYAFELA-RKRRKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIVTENLF 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 264 GNLVANTAAGIAGGTGVMPGGNVGQDH-AVFE-QGASA----GnvgnvkvveQKKANPVALLLSSAMMLRHLQFPSFADR 337
Cdd:COG0473   241 GDILSDLAAGLTGSLGLAPSANIGDEGkALFEpVHGSApdiaG---------KGIANPIATILSAAMMLRHLGEEEAADA 311

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1002237113 338 LETAVKRVIAEGkYRTKDLGGSSTTQEVTDAVIAHL 373
Cdd:COG0473   312 IEAAVEKVLAEG-VRTPDLGGKAGTSEMGDAIIAAL 346
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 49-373 3.31e-115

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 338.23  E-value: 3.31e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113  49 RAVTLIPGDGIGPLVTGAVRQVMEAMHAPVYFE-------SYEVRGDMptVPPEVIDSIRRNKVCLKGGLATPVGGGVSS 121
Cdd:PRK08997    3 QTITVIPGDGIGPSIIDATLKILDKLGCDFEYEfadagltALEKHGEL--LPQRTLDLIEKNKIALKGPLTTPVGEGFTS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 122 LNVQLRKELDLYASLVNCFNLPGLPTRHDNVDIVVIRENTEGEYSGLEHEVVP--GVVESLKFC----SERIAKYAFEYA 195
Cdd:PRK08997   81 INVTLRKKFDLYANVRPVLSFPGTKARYDNIDIITVRENTEGMYSGEGQTVSEdgETAEATSIItrkgAERIVRFAYELA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 196 YLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVANTAAGIA 275
Cdd:PRK08997  161 RKEGRKKVTAVHKANIMKSTSGLFLKVAREVALRYPDIEFEEMIVDATCMQLVMNPEQFDVIVTTNLFGDILSDLCAGLV 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 276 GGTGVMPGGNVGQDHAVFEQ-GASAGNVGNvkvveQKKANPVALLLSSAMMLRHLQFPSFADRLETAVKRVIAEGKYRTK 354
Cdd:PRK08997  241 GGLGMAPGANIGRDAAIFEAvHGSAPDIAG-----KNLANPTSVILAAIQMLEYLGMPDKAERIRKAIVAVIEAGDRTTR 315

                         330
                  ....*....|....*....
gi 1002237113 355 DLGGSSTTQEVTDAVIAHL 373
Cdd:PRK08997  316 DLGGTHGTTDFTQAVIDRL 334
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
51-373 5.21e-108

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 324.92  E-value: 5.21e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113  51 VTLIPGDGIGPLVTGAVRQVMEAMHAPVYFESYEV------RGDMPTVPPEVIDSIRRNKVCLKGGLATPVGGGVSSLNV 124
Cdd:PRK09222    7 ITVAYGDGIGPEIMEAVLKILEAAGAPLEIETIEIgekvykKGWTSGISPSAWESIRRTKVLLKAPITTPQGGGYKSLNV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 125 QLRKELDLYASLVNCFNL-PGLPTRHDNVDIVVIRENTEGEYSGLEHEVVPGVVESLKFC----SERIAKYAFEYAYLNN 199
Cdd:PRK09222   87 TLRKTLGLYANVRPCVSYhPFVETKHPNLDVVIIRENEEDLYAGIEHRQTPDVYQCLKLIsrpgSEKIIRYAFEYARANG 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 200 RKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVANTAAGIAGGTG 279
Cdd:PRK09222  167 RKKVTCLTKDNIMKLTDGLFHKVFDEIAKEYPDIEAEHYIVDIGAARLATNPENFDVIVTPNLYGDILSDIAAEISGSVG 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 280 VMPGGNVGQDHAVFE--QGAS---AGnvgnvkvveQKKANPVALLLSSAMMLRHLQFPSFADRLETAVKRVIAEGKYrTK 354
Cdd:PRK09222  247 LAGSANIGEEYAMFEavHGSApdiAG---------KNIANPSGLLNAAVMMLVHIGQFDIAELIENAWLKTLEDGIH-TA 316

                         330       340
                  ....*....|....*....|....*
gi 1002237113 355 DLGGSST------TQEVTDAVIAHL 373
Cdd:PRK09222  317 DIYNEGVskkkvgTKEFAEAVIENL 341
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
51-369 3.70e-99

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 297.67  E-value: 3.70e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113  51 VTLIPGDGIGPLVTGAVRQVMEAMHAPVYFE-SYEVR----------GDMptVPPEVIDSIRRNKVCLKGGLATPVG--G 117
Cdd:pfam00180   2 IAVLPGDGIGPEVMAAALKVLKAALEKAPLEfEFEERdvggaaidetGEP--LPDETLEACKKADAVLLGAVGGPKWdpA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 118 GVSSLN--VQLRKELDLYASLVNCFNLPGL----PTRHD--NVDIVVIRENTEGEYSGLEHEVVPG---VVESLKFCS-- 184
Cdd:pfam00180  80 GVRPENglLALRKELGLFANLRPAKVFPPLgdasPLKNEveGVDIVIVRELTGGIYFGIEKGIKGSgneVAVDTKLYSrd 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 185 --ERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNL 262
Cdd:pfam00180 160 eiERIARVAFELARKRGRKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPNL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 263 YGNLVANTAAGIAGGTGVMPGGNVGQD-HAVFEqgASAGNVgnVKVVEQKKANPVALLLSSAMMLRH-LQFPSFADRLET 340
Cdd:pfam00180 240 FGDILSDEASMLTGSLGLLPSASLGANgFGIFE--PVHGSA--PDIAGKGIANPIATILSAAMMLRYsLGLEDAADKIEA 315

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1002237113 341 AVKRVIAEGkYRTKDLGGSST---TQEVTDAV 369
Cdd:pfam00180 316 AVLKVLESG-IRTGDLAGSATyvsTSEFGEAV 346
LEU3_arch TIGR02088
isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal ...
 51-370 7.58e-86

isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal decarboxylating dehydrogenases which include the leucine biosynthesis enzyme 3-isopropylmalate dehydrogenase (LeuB, LEU3) and the methanogenic cofactor CoB biosynthesis enzyme isohomocitrate dehydrogenase (AksF). Both of these have been characterized in Methanococcus janaschii. Non-methanogenic archaea have only one hit to this model and presumably this is LeuB, although phylogenetic trees cannot establish which gene is which in the methanogens. The AksF gene is capable of acting on isohomocitrate, iso(homo)2-citrate and iso(homo)3-citrate in the successive elongation cycles of coenzyme B (7-mercaptoheptanoyl-threonine phosphate). This family is closely related to both the LeuB genes found in TIGR00169 and the mitochondrial eukaryotic isocitrate dehydratases found in TIGR00175. All of these are included within the broader subfamily model, pfam00180.


Pssm-ID: 273962  Cd Length: 322  Bit Score: 262.78  E-value: 7.58e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113  51 VTLIPGDGIGPLVTGAVRQVMEAMHAPVYFESYEVrGDM------PTVPPEVIDSIRRNKVCLKGGLATPVGGGVSSLNV 124
Cdd:TIGR02088   1 VAVIPGDGIGPEVIEAAIRILNKLGLEIEFIEFEA-GDEalkkygSALPEDTLEEIRKADAILFGAVTTPANPGYKSVIV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 125 QLRKELDLYASLVNCFNLPGLPTRH-DNVDIVVIRENTEGEYSGLEhEVVPGVVESLK----FCSERIAKYAFEYAYLNN 199
Cdd:TIGR02088  80 TLRKELDLYANVRPAKSLPGIPDLYpNGKDIVIVRENTEGLYAGFE-FGFSDRAIAIRvitrEGSERIARFAFNLAKERN 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 200 RKkVTAVHKANIMKLADGLFLESCREVATKYpGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVANTAAGIAGGTG 279
Cdd:TIGR02088 159 RK-VTCVHKANVLKGTDGLFREVCREIAKRY-GVEYRDMYVDSAAMNLVKDPWRFDVIVTTNMFGDILSDLASALAGSLG 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 280 VMPGGNVGQDHAVFE--QGASAGNVGnvkvveQKKANPVALLLSSAMMLRHLQFPSFADRLETAVKRVIAEGkYRTKDLG 357
Cdd:TIGR02088 237 LAPSANIGDRKALFEpvHGSAPDIAG------KGIANPTAAILSVAMMLDYLGELEKGKLVWEAVEYYIIEG-KKTPDLG 309

                         330
                  ....*....|...
gi 1002237113 358 GSSTTQEVTDAVI 370
Cdd:TIGR02088 310 GTAKTKEVGDEIA 322
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 51-373 9.21e-86

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 263.15  E-value: 9.21e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113  51 VTLIPGDGIGPLVTGAVRQVMEAMHAPVYF-------ESYEVRGDmpTVPPEVIDSIRRNKVCLKGGlatpVGGGVSSLN 123
Cdd:PRK14025    4 ICVIEGDGIGKEVVPAALHVLEATGLPFEFvyaeagdEVFEKTGK--ALPEETIEAAKEADAVLFGA----AGETAADVI 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 124 VQLRKELDLYASLVNCFNLPGLPTRHDNVDIVVIRENTEGEYSGLEHEVVPGVVESLKF----CSERIAKYAFEYA---- 195
Cdd:PRK14025   78 VKLRRILDTYANVRPVKSYKGVKCLYPDIDYVIVRENTEGLYKGIEAEIADGVTVATRVitrkASERIFRFAFEMAkrrk 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 196 YLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVANTAAGIA 275
Cdd:PRK14025  158 KMGKEGKVTCAHKANVLKKTDGLFKKTFYEVAKEYPDIKAEDYYVDAMNMYIITRPQTFDVVVTSNLFGDILSDGAAGLV 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 276 GGTGVMPGGNVGQDHAVFE--QGASAGNVGnvkvveQKKANPVALLLSSAMMLRHLQFPSFADRLETAVKRVIAEGKyRT 353
Cdd:PRK14025  238 GGLGLAPSANIGDKYGLFEpvHGSAPDIAG------KGIANPTATILTAVLMLRHLGENEEADKVEKALEEVLALGL-TT 310

                         330       340
                  ....*....|....*....|
gi 1002237113 354 KDLGGSSTTQEVTDAVIAHL 373
Cdd:PRK14025  311 PDLGGNLSTMEMAEEVAKRV 330
ICDH_alpha TIGR02924
isocitrate dehydrogenase; This family of mainly alphaproteobacterial enzymes is a member of ...
 51-374 3.72e-80

isocitrate dehydrogenase; This family of mainly alphaproteobacterial enzymes is a member of the isocitrate/isopropylmalate dehydrogenase superfamily described by pfam00180. Every member of the seed of this model appears to have a TCA cycle lacking only a determined isocitrate dehydrogenase. The precise identity of the cofactor (NADH -- 1.1.1.41 vs. NADPH -- 1.1.1.42) is unclear. [Energy metabolism, TCA cycle]


Pssm-ID: 274353 [Multi-domain]  Cd Length: 473  Bit Score: 253.15  E-value: 3.72e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113  51 VTLIPGDGIGPLVTGAVRQVMEAMHAPVYFESYEV------RGDMPTVPPEVIDSIRRNKVCLKGGLATPVGGGVSSLNV 124
Cdd:TIGR02924   3 ITVAYGDGIGPEIMEAVLLILKEAEAPIDIETIEIgekvykKGWPSGISPSSWESIRRTKVLLKAPITTPQGGGHKSLNV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 125 QLRKELDLYASLVNCFNL-PGLPTRHDNVDIVVIRENTEGEYSGLEHEVVPGVVESLKFC----SERIAKYAFEYAYLNN 199
Cdd:TIGR02924  83 TLRKTLGLYANIRPCVSYhPFIETKSPNLNIVIVRENEEDLYTGIEYRQTPDTYECTKLItrsgSEKICRYAFEYARKHN 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 200 RKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVANTAAGIAGGTG 279
Cdd:TIGR02924 163 RKKVTCLTKDNIMKMTDGIFHKIFDKIAAEYPDIESEHYIVDIGMARLATNPENFDVIVTPNLYGDILSDVAAEISGSVG 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 280 VMPGGNVGQDHAVFEqgASAGNVGNvkVVEQKKANPVALLLSSAMMLRHLQFPSFADRLETAVKRVIAEGKYrTKDLGGS 359
Cdd:TIGR02924 243 LAGSANIGEEYAMFE--AVHGSAPD--IAGQNIANPSGLLNAAIQMLVHIGQSDIAQLIYNAWLKTLEDGVH-TADIYNE 317

                         330       340
                  ....*....|....*....|.
gi 1002237113 360 ST------TQEVTDAVIAHLD 374
Cdd:TIGR02924 318 KTskqkvgTKEFAEAVTANLG 338
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 51-374 3.24e-71

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 226.52  E-value: 3.24e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113  51 VTLIPGDGIGPLVTGAVRQVMEAM-----------HAPVYFESYEVRGDMptVPPEVIDSIR------------------ 101
Cdd:PRK00772    5 IAVLPGDGIGPEVMAEAVKVLDAVaekfgfdfefeEALVGGAAIDAHGVP--LPEETLEACRaadavllgavggpkwdnl 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 102 -RNKVCLKGGLAtpvgggvsslnvqLRKELDLYASL--VNCFnlPGL-------PTRHDNVDIVVIRENTEGEYSG--LE 169
Cdd:PRK00772   83 pPDVRPERGLLA-------------LRKELGLFANLrpAKLY--PGLadasplkPEIVAGLDILIVRELTGGIYFGepRG 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 170 HEVVPG---VVESLKFCS---ERIAKYAFEYAyLNNRKKVTAVHKANIMKlADGLFLESCREVATKYPGIQYNEIIVDNC 243
Cdd:PRK00772  148 REGLGGeerAFDTMVYTReeiERIARVAFELA-RKRRKKVTSVDKANVLE-SSRLWREVVTEVAKEYPDVELSHMYVDNA 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 244 CMQLVAKPEQFDVMVTPNLYGNLVANTAAGIAGGTGVMPGGNVGQD-HAVFEQ-GAS----AGnvgnvkvveQKKANPVA 317
Cdd:PRK00772  226 AMQLVRNPKQFDVIVTENLFGDILSDEAAMLTGSLGMLPSASLGESgPGLYEPiHGSapdiAG---------KGIANPIA 296

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1002237113 318 LLLSSAMMLRHlqfpSF-----ADRLETAVKRVIAEGkYRTKDL---GGSSTTQEVTDAVIAHLD 374
Cdd:PRK00772  297 TILSAAMMLRY----SLgleeaADAIEAAVEKVLAQG-YRTADIaegGGKVSTSEMGDAILAALA 356
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 54-374 2.38e-64

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 210.35  E-value: 2.38e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113  54 IPGDGIGPLVTGAVRQVMEAMHAPVYF--------------ESYEVRGDMptVPPEVIDSIRRNKVCLKGGLATPVGGGV 119
Cdd:COG0538    24 IEGDGIGPEITRAIWKVIDAAVEKAYGgkrdiewkevdageKARDETGDW--LPDETAEAIKEYGVGIKGPLTTPVGGGW 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 120 SSLNVQLRKELDLYASL--VNCFnlPGLPT--RH-DNVDIVVIRENTEGEYSGLEHEV-VPGVVESLKF----------- 182
Cdd:COG0538   102 RSLNVTIRQILDLYVCRrpVRYF--KGVPSpvKHpEKVDIVIFRENTEDIYAGIEWKAgSPEALKLIFFledemgvtvir 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 183 ---------------CSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVATK-YP--------------- 231
Cdd:COG0538   180 fpedsgigikpvsdeGTERLVRAAIQYALDNKRKSVTLVHKGNIMKFTEGAFKDWGYEVAEEeFGdkfitegpwekykgp 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 232 ----GIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVANTAAGIAGGTGVMPGGNVGQD-HAVFEqgASAGNVgnVK 306
Cdd:COG0538   260 kpagKIVYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGANIGDDgGAEFE--ATHGTA--PK 335

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1002237113 307 VVEQKKANPVALLLSSAMMLRHLQFPSFADRLETAVKRVIAEGKYrTKDL-----GGSS-TTQEVTDAVIAHLD 374
Cdd:COG0538   336 YAGKDSTNPGSLILSGTMMLRHRGWLEAADLIEKAVEKTIESGKV-TYDLarlmeGATElSTSEFGDAIIENLD 408
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 54-347 4.19e-59

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 196.82  E-value: 4.19e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113  54 IPGDGIGPLVTGAVRQVMEAMHAPVYF--------------ESYEVRGDMPTVPPEVIDSIRRNKVCLKGGLATPVGGGV 119
Cdd:PRK07006   25 IEGDGIGPDITPAMLKVVDAAVEKAYKgerkiswmeiyageKATKVYGEDVWLPEETLDLIREYRVAIKGPLTTPVGGGI 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 120 SSLNVQLRKELDLYASL--VNCFNlpGLPT---RHDNVDIVVIRENTEGEYSGLEHEV----VPGVVESL---------- 180
Cdd:PRK07006  105 RSLNVALRQELDLYVCLrpVRYFK--GVPSpvkRPEDTDMVIFRENSEDIYAGIEWKAgsaeAKKVIKFLqeemgvkkir 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 181 ---------KFCS----ERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVATK------YPGIQYNEI--- 238
Cdd:PRK07006  183 fpetsgigiKPVSeegtERLVRAAIEYAIDNDRKSVTLVHKGNIMKFTEGAFKDWGYQLAEEefgdelIDGGPWDKIknp 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 239 -----------IVDNCCMQLVAKPEQFDVMVTPNLYGNLVANTAAGIAGGTGVMPGGNVGQDHAVFEqgASAGNVGnvKV 307
Cdd:PRK07006  263 etgkeiivkdsIADAFLQQILLRPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGANINDGHAIFE--ATHGTAP--KY 338

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1002237113 308 VEQKKANPVALLLSSAMMLRHLQFPSFADRLETAVKRVIA 347
Cdd:PRK07006  339 AGLDKVNPGSVILSAEMMLRHMGWTEAADLIIKSMEKTIA 378
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 54-373 5.91e-59

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 194.37  E-value: 5.91e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113  54 IPGDGIGPLVTGAVRQVMEAMHAPV------YF----ESYEVRGDmpTVPPEVIDSIRRNKVCLKGGLATP-VGGGV--S 120
Cdd:PRK03437   10 IPGDGIGPEVVAEALKVLDAVAAGGpgvettEYdlgaRRYLRTGE--TLPDSVLAELRQHDAILLGAIGDPsVPSGVleR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 121 SLNVQLRKELDLYASLVNCFNLPGLPTRHDN---VDIVVIRENTEGEYSG--------LEHEVVPGVVESLKFCSERIAK 189
Cdd:PRK03437   88 GLLLKLRFALDHYVNLRPSKLYPGVTSPLAGpgdIDFVVVREGTEGPYTGnggalrvgTPHEVATEVSVNTAFGVERVVR 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 190 YAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVAN 269
Cdd:PRK03437  168 DAFERAQKRPRKHLTLVHKTNVLTFAGDLWQRTVDEVAAEYPDVTVDYQHVDAATIFMVTDPSRFDVIVTDNLFGDIITD 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 270 TAAGIAGGTGVMPGGNVGQDHA---VFEQ-GASAGnvgnvKVVEQKKANPVALLLSSAMMLRHLQFPSFADRLETAVKRV 345
Cdd:PRK03437  248 LAAAVTGGIGLAASGNINPTGTnpsMFEPvHGSAP-----DIAGQGIADPTAAILSVALLLDHLGEEDAAARIEAAVEAD 322

                         330       340
                  ....*....|....*....|....*...
gi 1002237113 346 IAEgkyrtkDLGGSSTTQEVTDAVIAHL 373
Cdd:PRK03437  323 LAE------RGKMGRSTAEVGDRIAARL 344
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 51-373 2.45e-54

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 182.60  E-value: 2.45e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113  51 VTLIPGDGIGPLVTGAVRQVMEAM-----------HAPVYFESYEVRGDmpTVPPEVIDSIRRNKVCLKGGLATPV-GGG 118
Cdd:TIGR00169   2 IAVLPGDGIGPEVMAQALKVLKAVaerfglkfefeEHLIGGAAIDATGQ--PLPEETLKGCKEADAVLLGAVGGPKwDNL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 119 VSSLN-----VQLRKELDLYASLVNCFNLPGL----PTRHD---NVDIVVIRENTEGEYSG--LEHEVVPGVVESLKFCS 184
Cdd:TIGR00169  80 PRDQRpeqglLKLRKSLDLFANLRPAKVFPGLedlsPLKEEiakGVDFVVVRELTGGIYFGepKGREGEGEAWDTEVYTV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 185 ---ERIAKYAFEYAyLNNRKKVTAVHKANIMKLADgLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPN 261
Cdd:TIGR00169 160 peiERIARVAFEMA-RKRRKKVTSVDKANVLESSR-LWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVVTSN 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 262 LYGNLVANTAAGIAGGTGVMPGGNVGQD-HAVFE-QGASAGNVGNvkvveQKKANPVALLLSSAMMLRH-LQFPSFADRL 338
Cdd:TIGR00169 238 LFGDILSDEASVITGSLGMLPSASLGSDgFGLFEpVHGSAPDIAG-----KGIANPIAQILSAAMLLRYsFNLEEAADAI 312

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1002237113 339 ETAVKRVIAEGkYRTKDLGGSSTTQEVTDAVIAHL 373
Cdd:TIGR00169 313 EAAVKKVLAEG-YRTPDLGSSATTAVGTAEMGEEL 346
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
54-374 4.34e-54

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 183.88  E-value: 4.34e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113  54 IPGDGIGPLVTGAVRQVMEAMHAPVYFESYEVR------GDMPT------VPPEVIDSIRRNKVCLKGGLATPVGGGVSS 121
Cdd:PRK06451   29 VEGDGIGPEITHAAMKVINKAVEKAYGSDREIKwvevlaGDKAEkltgnrFPKESEELIEKYRVLLKGPLETPIGKGWKS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 122 LNVQLRKELDLYASLVNCFNLPGL--PTRH-DNVDIVVIRENTEGEYSGLEH------------------------EVVP 174
Cdd:PRK06451  109 INVAIRLMLDLYANIRPVKYIPGIesPLKNpEKIDLIIFRENTDDLYRGIEYpydseeakkirdflrkelgvevedDTGI 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 175 GVVESLKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVATK---------------YPG------I 233
Cdd:PRK06451  189 GIKLISKFKTQRIARMAIKYAIDHKRKKVTIMHKGNVMKYTEGAFREWAYEVALKefrdyvvteeevtknYNGvppsgkV 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 234 QYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVANTAAGIAGGTGVMPGGNVGQDHAVFE--QGASAGNVG-NVkvveq 310
Cdd:PRK06451  269 IINDRIADNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDTGGMFEaiHGTAPKYAGkNV----- 343

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1002237113 311 kkANPVALLLSSAMMLRHLQFPSFADRLETAVKRVIAEGKYrTKDLG-----GSSTTQEVTDAVIAHLD 374
Cdd:PRK06451  344 --ANPTGIIKGGELMLRFMGWDKAADLIDKAIMESIKQKKV-TQDLArfmgvRALSTTEYTDELISIID 409
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 51-373 7.08e-46

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 160.66  E-value: 7.08e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113  51 VTLIPGDGIGPLVTGAVRQVMEA---MHAPVYFE---------SYEVRGDMptVPPEVIDSIRRNKVCLKGGLATP--VG 116
Cdd:PRK08194    6 IAVIPGDGVGKEVVPAAVRVLKAvaeVHGGLKFEftefpwsceYYLEHGEM--MPEDGLEQLKQFDAIFLGAVGNPklVP 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 117 GGVS--SLNVQLRKELDLYASLVNCFNLPGL--PTRHDN-VDIVVIRENTEGEYSGL-------EHEVVpgvVESLKFC- 183
Cdd:PRK08194   84 DHISlwGLLIKIRREFEQVINIRPAKQLRGIksPLANPKdFDLLVVRENSEGEYSEVggrihrgEDEIA---IQNAVFTr 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 184 --SERIAKYAFEYAYlNNRKKVTAVHKAN----IMKLADGLFlescREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVM 257
Cdd:PRK08194  161 kgTERAMRYAFELAA-KRRKHVTSATKSNgivhSMPFWDEVF----QEVGKDYPEIETDSQHIDALAAFFVTRPEEFDVI 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 258 VTPNLYGNLVANTAAGIAGGTGVMPGGNV---GQDHAVFE--QGASAGNVGnvkvveQKKANPVALLLSSAMMLRHLQFP 332
Cdd:PRK08194  236 VASNLFGDILTDIGAAIMGSIGIAPAANInvnGKYPSMFEpvHGSAPDIAG------KGIANPIGQIWTAKLMLDHFGEE 309

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1002237113 333 SFADRLETAVKRVIAEGkYRTKDLGGSSTTQEVTDAVIAHL 373
Cdd:PRK08194  310 ELGSHLLDVIEDVTEDG-IKTPDIGGRATTDEVTDEIISRL 349
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
51-356 3.74e-38

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 142.54  E-value: 3.74e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113  51 VTLIPGDGIGPLVTGAVRQVMEAMHAPVY--------FESY------EVRGDMPTVPPEVIDSIRRNKVCLKGGLATPVG 116
Cdd:PRK07362   31 IPFIRGDGTGVDIWPATQKVLDAAVAKAYggerkinwFKVYagdeacDLYGTYQYLPEDTLEAIREYGVAIKGPLTTPIG 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 117 GGVSSLNVQLRKELDLYASLVNCFNLPGLPTRH---DNVDIVVIRENTEGEYSGLE----------------HEVVP--- 174
Cdd:PRK07362  111 GGIRSLNVALRQIFDLYSCVRPCRYYAGTPSPHknpEKLDVIVYRENTEDIYMGIEweagdeigdklikhlnEEVIPasp 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 175 -------------GVVESLKFCSERIAKYAFEYAYL--NNRKKVTAVHKANIMKLADGLFLESCREVAT----------- 228
Cdd:PRK07362  191 elgkrqiplgsgiGIKPVSKTGSQRHIRRAIEHALRlpGDKRHVTLVHKGNIMKYTEGAFRDWGYELATtefrdecvter 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 229 ---------KYPGIQY------------------------------------------------NEIIVDNCCMQLVAKP 251
Cdd:PRK07362  271 eswilsnkeKNPNISIednarmiepgydsltpekkaaicaevkevldsiwsshgngkwkekvlvDDRIADSIFQQIQTRP 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 252 EQFDVMVTPNLYGNLVANTAAGIAGGTGVMPGGNVGQDHAVFE--QGASAGNVGNVKVveqkkaNPVALLLSSAMMLRHL 329
Cdd:PRK07362  351 QEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDNAAIFEatHGTAPKHAGLDRI------NPGSVILSGVMMLEYL 424

                         410       420
                  ....*....|....*....|....*..
gi 1002237113 330 QFPSFADRLETAVKRVIAEGKYrTKDL 356
Cdd:PRK07362  425 GWQEAADLITKGLSAAIANKQV-TYDL 450
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 51-356 3.00e-26

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 108.62  E-value: 3.00e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113  51 VTLIPGDGIGPLVTGAVRQVMEA-----------MHAPVYFESYEVRGdMPtVPPEVIDSIRRNKVCLKGGlatpVGGGV 119
Cdd:PLN02329   49 IALLPGDGIGPEVISVAKNVLQKagsleglefdfQEMPVGGAALDLVG-VP-LPEETFTAAKQSDAILLGA----IGGYK 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 120 SSLN----------VQLRKELDLYASLVNCFNLPGLPTRH-------DNVDIVVIRENTEGEYSGLEHEV-VPGVVESLK 181
Cdd:PLN02329  123 WDKNekhlrpemalFYLRRDLKVFANLRPATVLPQLVDAStlkkevaEGVDMMIVRELTGGIYFGEPRGItINENGEEVG 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 182 FCSE--------RIAKYAFEYAYlNNRKKVTAVHKANIMKlADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQ 253
Cdd:PLN02329  203 VSTEiyaaheidRIARVAFETAR-KRRGKLCSVDKANVLD-ASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQ 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237113 254 FDVMVTPNLYGNLVANTAAGIAGGTGVMPGGNVGQDH-AVFE--QGASAGNVGnvkvveQKKANPVALLLSSAMMLRH-L 329
Cdd:PLN02329  281 FDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGpGLFEpiHGSAPDIAG------QDKANPLATILSAAMLLKYgL 354

                         330       340
                  ....*....|....*....|....*..
gi 1002237113 330 QFPSFADRLETAVKRVIAEGkYRTKDL 356
Cdd:PLN02329  355 GEEKAAKRIEDAVVDALNKG-FRTGDI 380
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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