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Conserved domains on  [gi|1002237709|ref|XP_015623065|]
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protein BOBBER 2 [Oryza sativa Japonica Group]

Protein Classification

NudC domain-containing protein( domain architecture ID 10158069)

NudC domain-containing protein similar to Aspergillus nidulans nuclear movement protein nudC that may interact between microtubules and nuclei and/or may be involved in the generation of force used to move nuclei during interphase

CATH:  2.60.40.790
PubMed:  21530541|26965524|12372593
SCOP:  4003073

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
p23_NUDC_like cd06467
p23_like domain of NUD (nuclear distribution) C and similar proteins. Aspergillus nidulas (An) ...
 209-293 1.26e-33

p23_like domain of NUD (nuclear distribution) C and similar proteins. Aspergillus nidulas (An) NUDC is needed for nuclear movement. AnNUDC is localized at the hyphal cortex, and binds NUDF at spindle pole bodies (SPBs) and in the cytoplasm at different stages in the cell cycle. At the SPBs it is part of the dynein molecular motor/NUDF complex that regulates microtubule dynamics. Mammalian(m) NUDC associates both with the dynein complex and also with an anti-inflammatory enzyme, platelet activating factor acetylhydrolase I, PAF-AH(I) complex, through binding mNUDF, the regulatory beta subunit of PAF-AH(I). mNUDC is important for cell proliferation both in normal and tumor tissues. Its expression is elevated in various cell types undergoing mitosis or stimulated to proliferate, with high expression levels observed in leukemic cells and tumors. For a leukemic cell line, human NUDC was shown to activate the thrombopoietin (TPO) receptor (Mpl) by binding to its extracellular domain, and promoting cell proliferation and differentiation. This group also includes the human broadly immunogenic tumor associated antigen, CML66, which is highly expressed in a variety of solid tumors and in leukemias. In normal tissues high expression of CML66 is limited to testis and heart.


:

Pssm-ID: 107224  Cd Length: 85  Bit Score: 119.57  E-value: 1.26e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237709 209 YSWTQERPEVTITIPVPQGTKSSLVTYEIMKNHLKVGLKGCSFIIDGELFEPVKVNDCLWTIEDGNTLSILLTKENQKEW 288
Cdd:cd06467     1 YSWTQTLDEVTVTIPLPEGTKSKDVKVEITPKHLKVGVKGGEPLLDGELYAKVKVDESTWTLEDGKLLEITLEKRNEGEW 80


                  ....*
gi 1002237709 289 WTSVI 293
Cdd:cd06467    81 WPSLV 85
PTZ00121 super family cl31754
MAEBL; Provisional
 131-197 4.17e-05

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.52  E-value: 4.17e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002237709  131 KRAKGEPRKAEEMLKEEEPMKAEEMLKEEEPMKAEEMLKEEPRTPMREAGRDKVERAAVVERVRDPK 197
Cdd:PTZ00121  1521 AKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAK 1587
 
Name Accession Description Interval E-value
p23_NUDC_like cd06467
p23_like domain of NUD (nuclear distribution) C and similar proteins. Aspergillus nidulas (An) ...
 209-293 1.26e-33

p23_like domain of NUD (nuclear distribution) C and similar proteins. Aspergillus nidulas (An) NUDC is needed for nuclear movement. AnNUDC is localized at the hyphal cortex, and binds NUDF at spindle pole bodies (SPBs) and in the cytoplasm at different stages in the cell cycle. At the SPBs it is part of the dynein molecular motor/NUDF complex that regulates microtubule dynamics. Mammalian(m) NUDC associates both with the dynein complex and also with an anti-inflammatory enzyme, platelet activating factor acetylhydrolase I, PAF-AH(I) complex, through binding mNUDF, the regulatory beta subunit of PAF-AH(I). mNUDC is important for cell proliferation both in normal and tumor tissues. Its expression is elevated in various cell types undergoing mitosis or stimulated to proliferate, with high expression levels observed in leukemic cells and tumors. For a leukemic cell line, human NUDC was shown to activate the thrombopoietin (TPO) receptor (Mpl) by binding to its extracellular domain, and promoting cell proliferation and differentiation. This group also includes the human broadly immunogenic tumor associated antigen, CML66, which is highly expressed in a variety of solid tumors and in leukemias. In normal tissues high expression of CML66 is limited to testis and heart.


Pssm-ID: 107224  Cd Length: 85  Bit Score: 119.57  E-value: 1.26e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237709 209 YSWTQERPEVTITIPVPQGTKSSLVTYEIMKNHLKVGLKGCSFIIDGELFEPVKVNDCLWTIEDGNTLSILLTKENQKEW 288
Cdd:cd06467     1 YSWTQTLDEVTVTIPLPEGTKSKDVKVEITPKHLKVGVKGGEPLLDGELYAKVKVDESTWTLEDGKLLEITLEKRNEGEW 80


                  ....*
gi 1002237709 289 WTSVI 293
Cdd:cd06467    81 WPSLV 85
CS pfam04969
CS domain; The CS and CHORD (pfam04968) are fused into a single polypeptide chain in metazoans ...
 207-282 1.97e-21

CS domain; The CS and CHORD (pfam04968) are fused into a single polypeptide chain in metazoans but are found in separate proteins in plants; this is thought to be indicative of an interaction between CS and CHORD. It has been suggested that the CS domain is a binding module for HSP90, implying that CS domain-containing proteins are involved in recruiting heat shock proteins to multiprotein assemblies. Two CS domains are found at the N-terminus of Ubiquitin carboxyl-terminal hydrolase 19 (USP19), these domains may play a role in the interaction of USP19 with cellular inhibitor of apoptosis 2.


Pssm-ID: 461503  Cd Length: 76  Bit Score: 86.93  E-value: 1.97e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002237709 207 EKYSWTQERPEVTITIPVPQ-GTKSSLVTYEIMKNHLKVGLKGCSFIIDGELFEPVKVNDCLWTIEdGNTLSILLTK 282
Cdd:pfam04969   1 PRYDWYQTLDEVTITIPVKGaGIKKKDVKVNIKPRSLKVKIKGGYELIDGELFHPIDPEESSWTIE-GKKVEITLKK 76
PTZ00121 PTZ00121
MAEBL; Provisional
 131-197 4.17e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.52  E-value: 4.17e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002237709  131 KRAKGEPRKAEEMLKEEEPMKAEEMLKEEEPMKAEEMLKEEPRTPMREAGRDKVERAAVVERVRDPK 197
Cdd:PTZ00121  1521 AKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAK 1587
 
Name Accession Description Interval E-value
p23_NUDC_like cd06467
p23_like domain of NUD (nuclear distribution) C and similar proteins. Aspergillus nidulas (An) ...
 209-293 1.26e-33

p23_like domain of NUD (nuclear distribution) C and similar proteins. Aspergillus nidulas (An) NUDC is needed for nuclear movement. AnNUDC is localized at the hyphal cortex, and binds NUDF at spindle pole bodies (SPBs) and in the cytoplasm at different stages in the cell cycle. At the SPBs it is part of the dynein molecular motor/NUDF complex that regulates microtubule dynamics. Mammalian(m) NUDC associates both with the dynein complex and also with an anti-inflammatory enzyme, platelet activating factor acetylhydrolase I, PAF-AH(I) complex, through binding mNUDF, the regulatory beta subunit of PAF-AH(I). mNUDC is important for cell proliferation both in normal and tumor tissues. Its expression is elevated in various cell types undergoing mitosis or stimulated to proliferate, with high expression levels observed in leukemic cells and tumors. For a leukemic cell line, human NUDC was shown to activate the thrombopoietin (TPO) receptor (Mpl) by binding to its extracellular domain, and promoting cell proliferation and differentiation. This group also includes the human broadly immunogenic tumor associated antigen, CML66, which is highly expressed in a variety of solid tumors and in leukemias. In normal tissues high expression of CML66 is limited to testis and heart.


Pssm-ID: 107224  Cd Length: 85  Bit Score: 119.57  E-value: 1.26e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237709 209 YSWTQERPEVTITIPVPQGTKSSLVTYEIMKNHLKVGLKGCSFIIDGELFEPVKVNDCLWTIEDGNTLSILLTKENQKEW 288
Cdd:cd06467     1 YSWTQTLDEVTVTIPLPEGTKSKDVKVEITPKHLKVGVKGGEPLLDGELYAKVKVDESTWTLEDGKLLEITLEKRNEGEW 80


                  ....*
gi 1002237709 289 WTSVI 293
Cdd:cd06467    81 WPSLV 85
p23_mNUDC_like cd06492
p23-like NUD (nuclear distribution) C-like domain of mammalian(m) NUDC and similar proteins. ...
 209-289 3.05e-22

p23-like NUD (nuclear distribution) C-like domain of mammalian(m) NUDC and similar proteins. Mammalian(m) NUDC associates both with the dynein complex and also with an anti-inflammatory enzyme, platelet activating factor acetylhydrolase I, PAF-AH(I) complex, through binding mNUDF, the regulatory beta subunit of PAF-AH(I). mNUDC is important for cell proliferation both in normal and tumor tissues. Its expression is elevated in various cell types undergoing mitosis or stimulated to proliferate, with high expression levels observed in leukemic cells and tumors. For a leukemic cell line, human NUDC was shown to activate the thrombopoietin (TPO) receptor (Mpl) by binding to its extracellular domain, and promoting cell proliferation and differentiation.


Pssm-ID: 107241  Cd Length: 87  Bit Score: 89.32  E-value: 3.05e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237709 209 YSWTQERPEVTITIP--VPQGTKSSLVTYEIMKNHLKVGLKGCSFIIDGELFEPVKVNDCLWTIEDGNTLSILLTKENQK 286
Cdd:cd06492     1 YRWTQTLSEVELKVPfkVSFRLKGKDVVVDIQRKHLKVGLKGQPPIIDGELYNEVKVEESSWLIEDGKVVTVNLEKINKM 80


                  ...
gi 1002237709 287 EWW 289
Cdd:cd06492    81 EWW 83
CS pfam04969
CS domain; The CS and CHORD (pfam04968) are fused into a single polypeptide chain in metazoans ...
 207-282 1.97e-21

CS domain; The CS and CHORD (pfam04968) are fused into a single polypeptide chain in metazoans but are found in separate proteins in plants; this is thought to be indicative of an interaction between CS and CHORD. It has been suggested that the CS domain is a binding module for HSP90, implying that CS domain-containing proteins are involved in recruiting heat shock proteins to multiprotein assemblies. Two CS domains are found at the N-terminus of Ubiquitin carboxyl-terminal hydrolase 19 (USP19), these domains may play a role in the interaction of USP19 with cellular inhibitor of apoptosis 2.


Pssm-ID: 461503  Cd Length: 76  Bit Score: 86.93  E-value: 1.97e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002237709 207 EKYSWTQERPEVTITIPVPQ-GTKSSLVTYEIMKNHLKVGLKGCSFIIDGELFEPVKVNDCLWTIEdGNTLSILLTK 282
Cdd:pfam04969   1 PRYDWYQTLDEVTITIPVKGaGIKKKDVKVNIKPRSLKVKIKGGYELIDGELFHPIDPEESSWTIE-GKKVEITLKK 76
p23_like cd06463
Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) ...
 211-293 4.93e-19

Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including the progesterone receptor. p23 also has a passive chaperoning activity and in addition may participate in prostaglandin synthesis. Both p23 and Sba1p can regulate telomerase activity. This group includes domains similar to the C-terminal CHORD-SGT1 (CS) domain of suppressor of G2 allele of Skp1 (Sgt1). Sgt1 interacts with multiple protein complexes and has the features of a co-chaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has been shown to bind Hsp90 through its CS domain. Saccharomyces cerevisiae (Sc) Sgt1 is a subunit of both core kinetochore and SCF (Skp1-Cul1-F-box) ubiquitin ligase complexes. Sgt1 is required for pathogen resistance in plants. This group also includes the p23_like domains of human butyrate-induced transcript 1 (hB-ind1), NUD (nuclear distribution) C, Melusin, and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR). hB-ind1 plays a role in the signaling pathway mediated by the small GTPase Rac1, NUDC is needed for nuclear movement, Melusin interacts with two splice variants of beta1 integrin, and NCB5OR plays a part in maintaining viable pancreatic beta cells.


Pssm-ID: 107220  Cd Length: 84  Bit Score: 80.41  E-value: 4.93e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237709 211 WTQERPEVTITIPVPQGTKSSlVTYEIMKNHLKVGLKGCS---FIIDGELFEPVKVNDCLWTIEDgNTLSILLTKENQKE 287
Cdd:cd06463     1 WYQTLDEVTITIPLKDVTKKD-VKVEFTPKSLTVSVKGGGgkeYLLEGELFGPIDPEESKWTVED-RKIEITLKKKEPGE 78


                  ....*.
gi 1002237709 288 WWTSVI 293
Cdd:cd06463    79 WWPRLE 84
p23_NUDCD2_like cd06494
p23-like NUD (nuclear distribution) C-like found in human NUDC domain-containing protein 2 ...
 210-293 4.62e-12

p23-like NUD (nuclear distribution) C-like found in human NUDC domain-containing protein 2 (NUDCD2) and similar proteins. Little is known about the function of the proteins in this subgroup.


Pssm-ID: 107243  Cd Length: 93  Bit Score: 61.70  E-value: 4.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237709 210 SWTQERPEVTITIPVPQGTKSSLVTYEIMKNHLKVGLKGcSFIIDGELFEPVKVNDCLWTIEDGNTLSILLTKENQK--E 287
Cdd:cd06494     9 CWYQTMDEVFIEVNVPPGTRAKDVKCKLGSRDISLAVKG-QEVLKGKLFDSVVADECTWTLEDRKLIRIVLTKSNRDagN 87


                  ....*.
gi 1002237709 288 WWTSVI 293
Cdd:cd06494    88 CWKSLL 93
p23_NUDCD1_like cd06493
p23_NUDCD1: p23-like NUD (nuclear distribution) C-like domain found in human NUD (nuclear ...
 209-293 2.42e-10

p23_NUDCD1: p23-like NUD (nuclear distribution) C-like domain found in human NUD (nuclear distribution) C domain-containing protein 1, NUDCD1 (also known as CML66), and similar proteins. NUDCD1/CML66 is a broadly immunogenic tumor associated antigen, which is highly expressed in a variety of solid tumors and in leukemias. In normal tissues high expression of NUDCD1/CML66 is limited to testis and heart.


Pssm-ID: 107242  Cd Length: 85  Bit Score: 56.38  E-value: 2.42e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237709 209 YSWTQERPEVTITIPVPQGTKSSLVTYEIMKNHLKVGLKGCSFIIDGELFEPVKVNDCLWTIEDGNTLSILLTKENQKEW 288
Cdd:cd06493     1 YYWQQTEEDLTLTIRLPEDTTKEDIRIKFLPDHISIALKDQAPLLEGKLYSSIDHESSTWIIKENKSLEVSLIKKDEGPT 80


                  ....*
gi 1002237709 289 WTSVI 293
Cdd:cd06493    81 WPELV 85
p23_NUDCD3_like cd06495
p23-like NUD (nuclear distribution) C-like domain found in human NUDC domain-containing ...
 207-300 1.40e-08

p23-like NUD (nuclear distribution) C-like domain found in human NUDC domain-containing protein 3 (NUDCD3) and similar proteins. Little is known about the function of the proteins in this subgroup.


Pssm-ID: 107244  Cd Length: 102  Bit Score: 51.80  E-value: 1.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237709 207 EKYSWTQERPEVTITIPVPQGT-KSSLVTYEIMKNHLKVGLK---GCSFIIDGELFEPVKVNDCLWTIEDGNTLSILLTK 282
Cdd:cd06495     5 ENYTWSQDYTDVEVRVPVPKDVvKGRQVSVDLQSSSIRVSVRdggGEKVLMEGEFTHKINTENSLWSLEPGKCVLLSLSK 84

                          90
                  ....*....|....*...
gi 1002237709 283 ENQKeWWTSVIKGDPELD 300
Cdd:cd06495    85 CSEV-WWNAVLKGEEEID 101
ACD_sHsps_p23-like cd00298
This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small ...
 211-282 5.54e-06

This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is this ACD. sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps. p23 is a cochaperone of the Hsp90 chaperoning pathway. It binds Hsp90 and participates in the folding of a number of Hsp90 clients including the progesterone receptor. p23 also has a passive chaperoning activity. p23 in addition may act as the cytosolic prostaglandin E2 synthase. Included in this family is the p23-like C-terminal CHORD-SGT1 (CS) domain of suppressor of G2 allele of Skp1 (Sgt1) and the p23-like domains of human butyrate-induced transcript 1 (hB-ind1), NUD (nuclear distribution) C, Melusin, and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR).


Pssm-ID: 107219  Cd Length: 80  Bit Score: 43.73  E-value: 5.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237709 211 WTQERPEVTITIPVPQGTKSSlVTYEIMKNHLKVGLKGC----------SFIIDGELFEPVKVNDCLWTIEDGnTLSILL 280
Cdd:cd00298     1 WYQTDDEVVVTVDLPGVKKED-IKVEVEDNVLTISGKREeeeerersygEFERSFELPEDVDPEKSKASLENG-VLEITL 78


                  ..
gi 1002237709 281 TK 282
Cdd:cd00298    79 PK 80
PTZ00121 PTZ00121
MAEBL; Provisional
 131-197 4.17e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.52  E-value: 4.17e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002237709  131 KRAKGEPRKAEEMLKEEEPMKAEEMLKEEEPMKAEEMLKEEPRTPMREAGRDKVERAAVVERVRDPK 197
Cdd:PTZ00121  1521 AKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAK 1587
PTZ00121 PTZ00121
MAEBL; Provisional
 132-215 2.56e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 2.56e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237709  132 RAKGEPRKAEEMLKEEEPMKAEEMLKEEEPMKAEEMLKEEPRTPMREAGRDKVERAAVVERVRDPKPNAGNGLDLEKYSW 211
Cdd:PTZ00121  1528 KKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKM 1607


                   ....
gi 1002237709  212 TQER 215
Cdd:PTZ00121  1608 KAEE 1611
PTZ00121 PTZ00121
MAEBL; Provisional
 115-194 2.82e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 2.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237709  115 EMAVEAQAKAEAEERRKRAKGEPRKAEEMLKEEE--PMKAEEMLK--EEEPMKAEEMLK-EEPRTPMREAGRDKVERAAV 189
Cdd:PTZ00121  1624 ELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEenKIKAAEEAKkaEEDKKKAEEAKKaEEDEKKAAEALKKEAEEAKK 1703


                   ....*
gi 1002237709  190 VERVR 194
Cdd:PTZ00121  1704 AEELK 1708
PTZ00121 PTZ00121
MAEBL; Provisional
 136-187 6.71e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.67  E-value: 6.71e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1002237709  136 EPRKAEEMLKEEEPMKAEEMLKEEEPMKAEEMLKEEPRTPMREAGRDKVERA 187
Cdd:PTZ00121  1276 EARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEA 1327
PTZ00121 PTZ00121
MAEBL; Provisional
 130-202 1.02e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.28  E-value: 1.02e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1002237709  130 RKRAKGEPRKAEEMLKEEEPMKAEEMLKEEEPMKAEEMLKEEPRTPMREAGRDKVERAAVVER-VRDPKPNAGN 202
Cdd:PTZ00121  1736 KKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKkIKDIFDNFAN 1809
PTZ00121 PTZ00121
MAEBL; Provisional
 130-188 1.30e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.89  E-value: 1.30e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237709  130 RKRAKGEPRKAEEMLK-EEEPMKAEEMLKEEEPMKAEEMLKEEPRTPMREAGRDKVERAA 188
Cdd:PTZ00121  1489 KKKAEEAKKKADEAKKaAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKA 1548
p23_CacyBP cd06468
p23_like domain found in proteins similar to Calcyclin-Binding Protein(CacyBP) ...
 206-292 1.66e-03

p23_like domain found in proteins similar to Calcyclin-Binding Protein(CacyBP)/Siah-1-interacting protein (SIP). CacyBP/SIP interacts with S100A6 (calcyclin), with some other members of the S100 family, with tubulin, and with Siah-1 and Skp-1. The latter two are components of the ubiquitin ligase that regulates beta-catenin degradation. The beta-catenin gene is an oncogene participating in tumorigenesis in many different cancers. Overexpression of CacyBP/SIP, in part through its effect on the expression of beta-catenin, inhibits the proliferation, tumorigenicity, and invasion of gastric cancer cells. CacyBP/SIP is abundant in neurons and neuroblastoma NB2a cells. An extensive re-organization of microtubules accompanies the differentiation of NB2a cells. CacyBP/SIP may contribute to NB2a cell differentiation through binding to and increasing the oligomerization of tubulin. CacyBP/SIP is also implicated in differentiation of erythroid cells, rat neonatal cardiomyocytes, in mouse endometrial events, and in thymocyte development.


Pssm-ID: 107225  Cd Length: 92  Bit Score: 37.24  E-value: 1.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237709 206 LEKYSWTQERPEVTITIPVP---QGTKSSL-VTYEIMKNHLKV-GLKGC--SFIIDGeLFEPVKVNDCLWTIEDgNTLSI 278
Cdd:cd06468     1 ITKYAWDQSDKFVKIYITLKgvhQLPKENIqVEFTERSFELKVhDLNGKnyRFTINR-LLKKIDPEKSSFKVKT-DRIVI 78

                          90
                  ....*....|....
gi 1002237709 279 LLTKENqKEWWTSV 292
Cdd:cd06468    79 TLAKKK-EKKWESL 91
PTZ00121 PTZ00121
MAEBL; Provisional
 132-214 4.00e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.35  E-value: 4.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002237709  132 RAKGEPRKAEEMLKEEEPMKAEEMLKEEEPMKAEEMLKEEPRTPMREAGR-DKVERAAVVERVRDPKPNAGNGLDLEKYS 210
Cdd:PTZ00121  1170 RKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKaEDAKKAEAVKKAEEAKKDAEEAKKAEEER 1249


                   ....
gi 1002237709  211 WTQE 214
Cdd:PTZ00121  1250 NNEE 1253
PTZ00121 PTZ00121
MAEBL; Provisional
 132-197 6.21e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 38.58  E-value: 6.21e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002237709  132 RAKGEPRKAEEMLKEEEPMKAEEMLKEEEPMKAEEMLKEEPRTPMREAGR-DKVERAAVVERVRDPK 197
Cdd:PTZ00121  1158 RKAEDARKAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKaEEERKAEEARKAEDAK 1224
PTZ00121 PTZ00121
MAEBL; Provisional
 129-197 7.38e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 38.58  E-value: 7.38e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1002237709  129 RRKRA------KGEPRKAEEMLKEEEPMKAEEMLKEEEPMKAEEMLKEEPRTPMREAGR-DKVERAAVVERVRDPK 197
Cdd:PTZ00121  1495 AKKKAdeakkaAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKaEELKKAEEKKKAEEAK 1570
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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