NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1002238373|ref|XP_015623395|]
View 

probable inactive histone-lysine N-methyltransferase SUVR2 [Oryza sativa Japonica Group]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 429-706 1.94e-76

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


:

Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 245.36  E-value: 1.94e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 429 PPFHYIPHNITLQEAYVnisLARIGDDNCCSdCFRDCLAQslPCACAAETGGEFAYTTDGLLKGafldscismireplkh 508
Cdd:cd10538     1 PSFTYIKDNIVGKNVQP---FSNIIDSVGCK-CKDDCLDS--KCACAAESDGIFAYTKNGLLRL---------------- 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 509 phfyckicpnermkievnsdssntemnpgpckgHLTRKFIKECWRKCGCTRNCGNRVVQRGITRHLQVFLTPeKKGWGLR 588
Cdd:cd10538    59 ---------------------------------NNSPPPIFECNSKCSCDDDCKNRVVQRGLQARLQVFRTS-KKGWGVR 104

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 589 STEKLPRGAFVCEYVGEILTNIELYDRtIQKTGKAKHTYPLLLDADWGTEGvlkDEEALCLDATFYGNVARFINHRCfDA 668
Cdd:cd10538   105 SLEFIPKGSFVCEYVGEVITTSEADRR-GKIYDKSGGSYLFDLDEFSDSDG---DGEELCVDATFCGNVSRFINHSC-DP 179

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1002238373 669 NIIGIPVEIETPDHHYYHLAFFTTRIIEPFEELTWDYG 706
Cdd:cd10538   180 NLFPFNVVIDHDDLRYPRIALFATRDILPGEELTFDYG 217
WIYLD pfam10440
Ubiquitin-binding WIYLD domain; This presumed domain has been predicted to contain three alpha ...
 24-80 1.17e-22

Ubiquitin-binding WIYLD domain; This presumed domain has been predicted to contain three alpha helices. The domain was named the WIYLD domain based on the pattern of most conserved residues. It binds ubiquitin. In the Arabidopsis thaliana histone-lysine N-methyltransferase SUVR4, binding of ubiquitin to this domain stimulates enzymatic activity and converts its activity from a strict dimethylase to a di/trimethylase.


:

Pssm-ID: 431288  Cd Length: 58  Bit Score: 91.54  E-value: 1.17e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1002238373  24 KDRFDAAIRAMADIGILKETAAPVLNNLLNLFDYNWVHIEADNYLALADAIFCDSDP 80
Cdd:pfam10440   2 DRRIDAAIDAMRPLGIPKEKIRPVLKNLLKVYGGNWPLIEEDNYRVLADAIFEKQDE 58
 
Name Accession Description Interval E-value
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 429-706 1.94e-76

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 245.36  E-value: 1.94e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 429 PPFHYIPHNITLQEAYVnisLARIGDDNCCSdCFRDCLAQslPCACAAETGGEFAYTTDGLLKGafldscismireplkh 508
Cdd:cd10538     1 PSFTYIKDNIVGKNVQP---FSNIIDSVGCK-CKDDCLDS--KCACAAESDGIFAYTKNGLLRL---------------- 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 509 phfyckicpnermkievnsdssntemnpgpckgHLTRKFIKECWRKCGCTRNCGNRVVQRGITRHLQVFLTPeKKGWGLR 588
Cdd:cd10538    59 ---------------------------------NNSPPPIFECNSKCSCDDDCKNRVVQRGLQARLQVFRTS-KKGWGVR 104

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 589 STEKLPRGAFVCEYVGEILTNIELYDRtIQKTGKAKHTYPLLLDADWGTEGvlkDEEALCLDATFYGNVARFINHRCfDA 668
Cdd:cd10538   105 SLEFIPKGSFVCEYVGEVITTSEADRR-GKIYDKSGGSYLFDLDEFSDSDG---DGEELCVDATFCGNVSRFINHSC-DP 179

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1002238373 669 NIIGIPVEIETPDHHYYHLAFFTTRIIEPFEELTWDYG 706
Cdd:cd10538   180 NLFPFNVVIDHDDLRYPRIALFATRDILPGEELTFDYG 217
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 572-711 7.39e-30

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 114.35  E-value: 7.39e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373  572 RHLQVFLTPEKkGWGLRSTEKLPRGAFVCEYVGEILTNIELYDRTIQ-KTGKAKHTYplLLDADWGtegvlkdeeaLCLD 650
Cdd:smart00317   1 NKLEVFKSPGK-GWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAyDTDGAKAFY--LFDIDSD----------LCID 67

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1002238373  651 ATFYGNVARFINHRCfDANIIGIPVEIETPDhhyyHLAFFTTRIIEPFEELTWDYGIDFDD 711
Cdd:smart00317  68 ARRKGNLARFINHSC-EPNCELLFVEVNGDD----RIVIFALRDIKPGEELTIDYGSDYAN 123
WIYLD pfam10440
Ubiquitin-binding WIYLD domain; This presumed domain has been predicted to contain three alpha ...
 24-80 1.17e-22

Ubiquitin-binding WIYLD domain; This presumed domain has been predicted to contain three alpha helices. The domain was named the WIYLD domain based on the pattern of most conserved residues. It binds ubiquitin. In the Arabidopsis thaliana histone-lysine N-methyltransferase SUVR4, binding of ubiquitin to this domain stimulates enzymatic activity and converts its activity from a strict dimethylase to a di/trimethylase.


Pssm-ID: 431288  Cd Length: 58  Bit Score: 91.54  E-value: 1.17e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1002238373  24 KDRFDAAIRAMADIGILKETAAPVLNNLLNLFDYNWVHIEADNYLALADAIFCDSDP 80
Cdd:pfam10440   2 DRRIDAAIDAMRPLGIPKEKIRPVLKNLLKVYGGNWPLIEEDNYRVLADAIFEKQDE 58
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 584-706 1.61e-20

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 87.58  E-value: 1.61e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 584 GWGLRSTEKLPRGAFVCEYVGEILTNIELYDR---TIQKTGKAKHTYPLLLDadwgtegvLKDEEALCLDAT--FYGNVA 658
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVLLITKEEADKrelLYYDKLELRLWGPYLFT--------LDEDSEYCIDARalYYGNWA 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1002238373 659 RFINHRCfDANIIGIPVEIETpdhhYYHLAFFTTRIIEPFEELTWDYG 706
Cdd:pfam00856  73 RFINHSC-DPNCEVRVVYVNG----GPRIVIFALRDIKPGEELTIDYG 115
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
581-729 1.30e-19

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 85.40  E-value: 1.30e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 581 EKKGWGLRSTEKLPRGAFVCEYVGEILTNIELYDRTIQKTgkAKHTYPLLLDADWGtegvlkdeealcLDATFYGNVARF 660
Cdd:COG2940    14 PIHGRGVFATRDIPKGTLIGEYPGEVITWAEAERREPHKE--PLHTYLFELDDDGV------------IDGALGGNPARF 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1002238373 661 INHRCfDANiigipVEIETPDHHYYhlaFFTTRIIEPFEELTWDYGIDFDDvdhpvKAFKCHCGSefCR 729
Cdd:COG2940    80 INHSC-DPN-----CEADEEDGRIF---IVALRDIAAGEELTYDYGLDYDE-----EEYPCRCPN--CR 132
 
Name Accession Description Interval E-value
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 429-706 1.94e-76

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 245.36  E-value: 1.94e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 429 PPFHYIPHNITLQEAYVnisLARIGDDNCCSdCFRDCLAQslPCACAAETGGEFAYTTDGLLKGafldscismireplkh 508
Cdd:cd10538     1 PSFTYIKDNIVGKNVQP---FSNIIDSVGCK-CKDDCLDS--KCACAAESDGIFAYTKNGLLRL---------------- 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 509 phfyckicpnermkievnsdssntemnpgpckgHLTRKFIKECWRKCGCTRNCGNRVVQRGITRHLQVFLTPeKKGWGLR 588
Cdd:cd10538    59 ---------------------------------NNSPPPIFECNSKCSCDDDCKNRVVQRGLQARLQVFRTS-KKGWGVR 104

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 589 STEKLPRGAFVCEYVGEILTNIELYDRtIQKTGKAKHTYPLLLDADWGTEGvlkDEEALCLDATFYGNVARFINHRCfDA 668
Cdd:cd10538   105 SLEFIPKGSFVCEYVGEVITTSEADRR-GKIYDKSGGSYLFDLDEFSDSDG---DGEELCVDATFCGNVSRFINHSC-DP 179

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1002238373 669 NIIGIPVEIETPDHHYYHLAFFTTRIIEPFEELTWDYG 706
Cdd:cd10538   180 NLFPFNVVIDHDDLRYPRIALFATRDILPGEELTFDYG 217
SET_SUV39H cd10542
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 429-729 1.66e-53

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homologs, SUV39H1, SUV39H2 and similar proteins; This family includes SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. Also included are Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (SUV39H homolog) and Neurospora crassa DIM-5, both of which also methylate 'Lys-9' of histone H3.


Pssm-ID: 380940 [Multi-domain]  Cd Length: 245  Bit Score: 184.80  E-value: 1.66e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 429 PPFHYIPHNITLQEAYVNISlARIGddncCsDCFRDCLAQSLPCaCAAETGGEFAYTTDGLLkgafldscismiREPLKH 508
Cdd:cd10542     1 PNFQYINDYIPGDGVKIPED-FLVG----C-ECTEDCHNNNPTC-CPAESGVKFAYDKQGRL------------RLPPGT 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 509 PhfyckicpnermkievnsdssntemnpgpckghltrkfIKECWRKCGCTRNCGNRVVQRGITRHLQVFLTPEKKGWGLR 588
Cdd:cd10542    62 P--------------------------------------IYECNSRCKCGPDCPNRVVQRGRKVPLCIFRTSNGRGWGVK 103

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 589 STEKLPRGAFVCEYVGEILTNIE------LYDRTiqktgkaKHTYplLLDADWgtegvLKDEEALCLDATFYGNVARFIN 662
Cdd:cd10542   104 TLEDIKKGTFVMEYVGEIITSEEaerrgkIYDAN-------GRTY--LFDLDY-----NDDDCEYTVDAAYYGNISHFIN 169

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1002238373 663 HRCfDANIIGIPVEIETPDHHYYHLAFFTTRIIEPFEELTWDY--GIDFDDVDHPVKA-----FKCHCGSEFCR 729
Cdd:cd10542   170 HSC-DPNLAVYAVWINHLDPRLPRIAFFAKRDIKAGEELTFDYlmTGTGGSSESTIPKpkdvrVPCLCGSKNCR 242
SET_EHMT cd10543
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 542-729 4.76e-51

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase EHMT1, EHMT2 and similar proteins; This family includes EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380941 [Multi-domain]  Cd Length: 231  Bit Score: 177.92  E-value: 4.76e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 542 HLTRKFIKECWRKCGCTRNCGNRVVQRGITRHLQVFLTpEKKGWGLRSTEKLPRGAFVCEYVGEILTNIELYDRtiqktg 621
Cdd:cd10543    61 KLDPPLIFECNRACSCWRNCRNRVVQNGIRYRLQLFRT-RGMGWGVRALQDIPKGTFVCEYIGELISDSEADSR------ 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 622 kAKHTYplLLDADwgtegvLKDEEALCLDATFYGNVARFINHRCfDANIIGIPVEIETPDHHYYHLAFFTTRIIEPFEEL 701
Cdd:cd10543   134 -EDDSY--LFDLD------NKDGETYCIDARRYGNISRFINHLC-EPNLIPVRVFVEHQDLRFPRIAFFASRDIKAGEEL 203

                         170       180
                  ....*....|....*....|....*...
gi 1002238373 702 TWDYGIDFDDVDHpvKAFKCHCGSEFCR 729
Cdd:cd10543   204 GFDYGEKFWRIKG--KYFTCRCGSPKCK 229
SET_SETDB1 cd10517
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 404-729 1.96e-42

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.


Pssm-ID: 380915 [Multi-domain]  Cd Length: 288  Bit Score: 155.91  E-value: 1.96e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 404 VNDITKGEERLRIPIINEYGNgILPPPFHYIPHNITLQEayVNISLARigDDNCCSDCFRDCLAQSlPCACAAETGGEFA 483
Cdd:cd10517     6 ICDISYGKEGVPIPCVNEIDN-SSPPYVEYSKERIPGKG--VNINLDP--DFLVGCDCTDGCRDKS-KCACQQLTIEATA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 484 YTTDGllkgafldscismireplkhphfyckicpnermkievnsdSSNTEmnPGPCKGHLTRKF---IKECWRKCGCTRN 560
Cdd:cd10517    80 ATPGG----------------------------------------QINPS--AGYQYRRLMEKLptgVYECNSRCKCDKR 117

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 561 CGNRVVQRGITRHLQVFLTpEKKGWGLRSTEKLPRGAFVCEYVGEILTNIELyDRTIQKTGKakhTYPLLLD----ADWG 636
Cdd:cd10517   118 CYNRVVQNGLQVRLQVFKT-EKKGWGIRCLDDIPKGSFVCIYAGQILTEDEA-NEEGLQYGD---EYFAELDyievVEKL 192

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 637 TEGVLKDEEALC--LDATFYGNVARFINHRCfDANIIGIPVEIETPDHHYYHLAFFTTRIIEPFEELTWDYGIDFDDVdh 714
Cdd:cd10517   193 KEGYESDVEEHCyiIDAKSEGNLGRYLNHSC-SPNLFVQNVFVDTHDLRFPWVAFFASRYIRAGTELTWDYNYEVGSV-- 269

                         330
                  ....*....|....*
gi 1002238373 715 PVKAFKCHCGSEFCR 729
Cdd:cd10517   270 PGKVLYCYCGSSNCR 284
SET_EHMT1 cd10535
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 547-729 1.21e-41

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins; EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, or lysine N-methyltransferase 1D (KMT1D)) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380933 [Multi-domain]  Cd Length: 231  Bit Score: 151.62  E-value: 1.21e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 547 FIKECWRKCGCTRNCGNRVVQRGITRHLQVFLTpEKKGWGLRSTEKLPRGAFVCEYVGEILTNIELYDRtiqktgkAKHT 626
Cdd:cd10535    66 LIFECNHACSCWRNCRNRVVQNGLRARLQLYRT-RDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVR-------EEDS 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 627 YPLLLDAdwgtegvlKDEEALCLDATFYGNVARFINHRCfDANIIGIPVEIETPDHHYYHLAFFTTRIIEPFEELTWDYG 706
Cdd:cd10535   138 YLFDLDN--------KDGEVYCIDARFYGNVSRFINHHC-EPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYG 208

                         170       180
                  ....*....|....*....|...
gi 1002238373 707 IDFDDVDHpvKAFKCHCGSEFCR 729
Cdd:cd10535   209 ERFWDIKG--KLFSCRCGSPKCR 229
SET_SETMAR cd10544
SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...
 548-729 1.50e-41

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.


Pssm-ID: 380942 [Multi-domain]  Cd Length: 254  Bit Score: 152.07  E-value: 1.50e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 548 IKECWRKCGCTRNCGNRVVQRGITRHLQVFLTPeKKGWGLRSTEKLPRGAFVCEYVGEILTNIELYDRTiQKTGKAKHTY 627
Cdd:cd10544    66 VFECNSMCKCSESCQNRVVQNGLQFKLQVFKTP-KKGWGLRTLEFIPKGRFVCEYAGEVIGFEEARRRT-KSQTKGDMNY 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 628 PLLLDADWGTEGVLKDeealCLDATFYGNVARFINHRCfDANIIGIPVEIETPdhhYYHLAFFTTRIIEPFEELTWDYGI 707
Cdd:cd10544   144 IIVLREHLSSGKVLET----FVDPTYIGNIGRFLNHSC-EPNLFMVPVRVDSM---VPKLALFAARDIVAGEELSFDYSG 215

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1002238373 708 DFD---------DVDHPVKAFKCHCGSEFCR 729
Cdd:cd10544   216 EFSnsvesvtlaRQDESKSRKPCLCGAENCR 246
SET_EHMT2 cd10533
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 547-729 1.06e-38

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins; EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C (KMT1C), or protein G9a) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380931 [Multi-domain]  Cd Length: 239  Bit Score: 143.62  E-value: 1.06e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 547 FIKECWRKCGCTRNCGNRVVQRGITRHLQVFLTpEKKGWGLRSTEKLPRGAFVCEYVGEILTNIElydrtiqktGKAKHT 626
Cdd:cd10533    66 LIFECNQACSCWRNCKNRVVQSGIKVRLQLYRT-AKMGWGVRALQTIPQGTFICEYVGELISDAE---------ADVRED 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 627 YPLLLDADwgtegvLKDEEALCLDATFYGNVARFINHRCfDANIIGIPVEIETPDHHYYHLAFFTTRIIEPFEELTWDYG 706
Cdd:cd10533   136 DSYLFDLD------NKDGEVYCIDARYYGNISRFINHLC-DPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYG 208

                         170       180
                  ....*....|....*....|...
gi 1002238373 707 IDFDDVDHpvKAFKCHCGSEFCR 729
Cdd:cd10533   209 DRFWDIKS--KYFTCQCGSEKCK 229
SET_AtSUVH-like cd10545
SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar ...
 460-706 1.01e-37

SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar proteins; Arabidopsis thaliana SUVH protein (also termed suppressor of variegation 3-9 homolog protein) is a histone-lysine N-methyltransferase that methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. Some family members contain a post-SET domain which binds a Zn2+ ion. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380943 [Multi-domain]  Cd Length: 232  Bit Score: 140.62  E-value: 1.01e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 460 DCFRDCLAQSLPCACAAETGGEFAYTTDGLLKGAFldscismireplkhphfyckicpnermkievnsdssntemnpgPC 539
Cdd:cd10545    25 DCKNRCTDGASDCACVKKNGGEIPYNFNGRLIRAK-------------------------------------------PA 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 540 kghltrkfIKECWRKCGCTRNCGNRVVQRGITRHLQVFLTpEKKGWGLRSTEKLPRGAFVCEYVGEILTNIE-------- 611
Cdd:cd10545    62 --------IYECGPLCKCPPSCYNRVTQKGLRYRLEVFKT-AERGWGVRSWDSIPAGSFICEYVGELLDTSEadtrsgnd 132

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 612 --LYDRTIQKTGKAKHTYPLLL--DADWGTEGVLKDEEA-LCLDATFYGNVARFINHRCfDANIIGIPVEIETPDHHYYH 686
Cdd:cd10545   133 dyLFDIDNRQTNRGWDGGQRLDvgMSDGERSSAEDEESSeFTIDAGSFGNVARFINHSC-SPNLFVQCVLYDHNDLRLPR 211

                         250       260
                  ....*....|....*....|
gi 1002238373 687 LAFFTTRIIEPFEELTWDYG 706
Cdd:cd10545   212 VMLFAADNIPPLQELTYDYG 231
SET_SUV39H_DIM5-like cd19473
SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; ...
 537-730 9.45e-37

SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; This subfamily contains Neurospora crassa DIM-5 (also termed H3-K9-HMTase dim-5, or HKMT) which functions as histone-lysine N-methyltransferase that specifically trimethylates histone H3 to form H3K9me3.


Pssm-ID: 380996 [Multi-domain]  Cd Length: 274  Bit Score: 139.37  E-value: 9.45e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 537 GPCKGHL------TRKFIKECWRKCGCTRNCGNRVVQRGITRHLQVFLTPEKKGWGLRSTEKLPRGAFVCEYVGEILTNI 610
Cdd:cd19473    64 GAKKGCLrghmlnSRLPIYECHEGCACSDDCPNRVVERGRKVPLQIFRTSDGRGWGVRSTVDIKRGQFVDCYVGEIITPE 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 611 ELyDRTIQKTGKAKHTYPLLLDADWGTEGVLKDE----EALCLDATFYGNVARFINHRCfDANIIGIPVEIETPDHHYYH 686
Cdd:cd19473   144 EA-QRRRDAATIAQRKDVYLFALDKFSDPDSLDPrlrgDPYEIDGEFMSGPTRFINHSC-DPNLRIFARVGDHADKHIHD 221

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1002238373 687 LAFFTTRIIEPFEELTWDY--GIDFDDVDHPVKA-----FKCHCGSEFCRD 730
Cdd:cd19473   222 LAFFAIKDIPRGTELTFDYvdGVTGLDDDAGDEEkekemTKCLCGSPKCRG 272
SET_SETDB2 cd10523
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) ...
 548-731 4.30e-32

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) and similar proteins; SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380921 [Multi-domain]  Cd Length: 266  Bit Score: 125.71  E-value: 4.30e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 548 IKECWRKCGCTRN-CGNRVVQRGITRHLQVFLTpEKKGWGLRSTEKLPRGAFVCEYVGEILTNIElydrtiqkTGKAKHT 626
Cdd:cd10523    83 LYECNVSCKCNRMlCQNRVVQHGLQVRLQVFKT-EKKGWGVRCLDDIDKGTFVCIYAGRVLSRAR--------SPTEPLP 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 627 YPLLLDADWGTEGVL---------KDEEALC-LDATFYGNVARFINHRCFdANIIGIPVEIETPDHHYYHLAFFTTRIIE 696
Cdd:cd10523   154 PKLELPSENEVEVVTswlilskkrKLRENVCfLDASKEGNVGRFLNHSCC-PNLFVQNVFVDTHDKNFPWVAFFTNRVVK 232

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1002238373 697 PFEELTWDYGIDFDDVdhPVKAFKCHCGSEFCRDK 731
Cdd:cd10523   233 AGTELTWDYSYDAGTS--PEQEIPCLCGVNKCQKK 265
SET_SUV39H1 cd10525
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 548-729 4.36e-31

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 1 (SUV39H1) and similar proteins; SUV39H1 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A (KMT1A), position-effect variegation 3-9 homolog (SUV39H), or Su(var)3-9 homolog 1) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380923 [Multi-domain]  Cd Length: 255  Bit Score: 122.31  E-value: 4.36e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 548 IKECWRKCGCTRNCGNRVVQRGITRHLQVFLTPEKKGWGLRSTEKLPRGAFVCEYVGEILTNIELyDRTIQKTGKAKHTY 627
Cdd:cd10525    62 IYECNSRCRCGPDCPNRVVQKGIQYDLCIFRTDNGRGWGVRTLEKIRKNSFVMEYVGEIITSEEA-ERRGQIYDRQGATY 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 628 plLLDADWgtegvlkDEEALCLDATFYGNVARFINHRCfDANIIGIPVEIETPDHHYYHLAFFTTRIIEPFEELTWDYGI 707
Cdd:cd10525   141 --LFDLDY-------VEDVYTVDAAYYGNISHFVNHSC-DPNLQVYNVFIDNLDERLPRIALFATRTIRAGEELTFDYNM 210

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1002238373 708 DFDDVD-----------------HPVKAFK--CHCGSEFCR 729
Cdd:cd10525   211 QVDPVDaestkmdsnfglaglpgSPKKRVRieCKCGVRSCR 251
SET_SUV39H_Clr4-like cd20073
SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 ...
 548-729 1.71e-30

SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 methyltransferase Clr4, and similar proteins; This subfamily contains fission yeast Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (also known as Suv39h), the sole homolog of the mammalian SUV39H1 and SUV39H2 enzymes, that has a critical role in preventing aberrant heterochromatin formation. It is known to di- and tri-methylate Lys-9 of histone H3, a central heterochromatic histone modification, with its specificity profile most similar to that of the human SUV39H2 homolog.


Pssm-ID: 380999 [Multi-domain]  Cd Length: 259  Bit Score: 120.75  E-value: 1.71e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 548 IKECWRKCGCTRNCGNRVVQRGITRHLQVFLTPEkKGWGLRSTEKLPRGAFVCEYVGEILTNIELYDRTiQKTGKAKHTY 627
Cdd:cd20073    69 IYECNENCDCGINCPNRVVQRGRKLPLEIFKTKH-KGWGLRCPRFIKAGTFIGVYLGEVITQSEAEIRG-KKYDNVGVTY 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 628 plLLDADWGTEGVlkdEEALCLDATFYGNVARFINHRCfDANIIGIPVEIETPDHHYYHLAFFTTRIIEPFEELTWDYGI 707
Cdd:cd20073   147 --LFDLDLFEDQV---DEYYTVDAQYCGDVTRFINHSC-DPNLAIYSVLRDKSDSKIYDLAFFAIKDIPALEELTFDYSG 220

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1002238373 708 DFDdvDHPV-----------KAFK----CHCGSEFCR 729
Cdd:cd20073   221 RNN--FDQLgfignrsnskyINLKnkrpCYCGSANCR 255
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 572-711 7.39e-30

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 114.35  E-value: 7.39e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373  572 RHLQVFLTPEKkGWGLRSTEKLPRGAFVCEYVGEILTNIELYDRTIQ-KTGKAKHTYplLLDADWGtegvlkdeeaLCLD 650
Cdd:smart00317   1 NKLEVFKSPGK-GWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAyDTDGAKAFY--LFDIDSD----------LCID 67

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1002238373  651 ATFYGNVARFINHRCfDANIIGIPVEIETPDhhyyHLAFFTTRIIEPFEELTWDYGIDFDD 711
Cdd:smart00317  68 ARRKGNLARFINHSC-EPNCELLFVEVNGDD----RIVIFALRDIKPGEELTIDYGSDYAN 123
SET_SUV39H2 cd10532
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 511-729 9.89e-29

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins; SUV39H2 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B (KMT1B), or Su(var)3-9 homolog 2) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380930 [Multi-domain]  Cd Length: 243  Bit Score: 115.37  E-value: 9.89e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 511 FYCKICPNERMKIEVNSDSSNTEMNPGpckghltrKFIKECWRKCGCTRNCGNRVVQRGITRHLQVFLTPEKKGWGLRST 590
Cdd:cd10532    31 FFGKCCPAEAGVLFAYNEHGQLKIPPG--------TPIYECNSRCKCGPDCPNRVVQKGTQYSLCIFRTSNGRGWGVKTL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 591 EKLPRGAFVCEYVGEILTNiELYDRTIQKTGKAKHTYplLLDADWgtegvlkDEEALCLDATFYGNVARFINHRCfDANI 670
Cdd:cd10532   103 QKIKKNSFVMEYVGEVITS-EEAERRGQFYDSKGITY--LFDLDY-------ESDEFTVDAARYGNVSHFVNHSC-DPNL 171

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1002238373 671 IGIPVEIETPDHHYYHLAFFTTRIIEPFEELTWDY------GIDFDDVDH-PVKA---FKCHCGSEFCR 729
Cdd:cd10532   172 QVFNVFIDNLDTRLPRIALFSTRTIKAGEELTFDYqmkgsgDLSSDSIDNsPAKKrvrTVCKCGAVTCR 240
SET_SETDB cd10541
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), ...
 548-731 2.13e-28

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), SET domain bifurcated 2 (SETDB2), and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380939 [Multi-domain]  Cd Length: 236  Bit Score: 114.18  E-value: 2.13e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 548 IKECWRKCGCTRN-CGNRVVQRGITRHLQVFLTpEKKGWGLRSTEKLPRGAFVCEYVGEILTNielyDRTIQKTGKAKHT 626
Cdd:cd10541    67 VYECNKLCKCDPNmCQNRLVQHGLQVRLQLFKT-QNKGWGIRCLDDIAKGTFVCIYAGKILTD----DFADKEGLEMGDE 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 627 YPLLLDAdwgtegvlKDEEALCLDATFYGNVARFINHRCfDANIIGIPVEIETPDHHYYHLAFFTTRIIEPFEELTWDYG 706
Cdd:cd10541   142 YFANLDH--------IEESCYIIDAKLEGNLGRYLNHSC-SPNLFVQNVFVDTHDLRFPWVAFFASKRIKAGTELTWDYN 212

                         170       180
                  ....*....|....*....|....*
gi 1002238373 707 IDFDDVdhPVKAFKCHCGSEFCRDK 731
Cdd:cd10541   213 YEVGSV--EGKELLCCCGSNECRGR 235
SET_SETD2 cd19172
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...
 576-729 1.54e-26

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.


Pssm-ID: 380949 [Multi-domain]  Cd Length: 142  Bit Score: 105.74  E-value: 1.54e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 576 VFLTpEKKGWGLRSTEKLPRGAFVCEYVGEILTNIELYDRTIQKTG-KAKHTYPLLLDadwgtegvlKDEealCLDATFY 654
Cdd:cd19172     6 VFRT-EKKGWGLRAAEDLPKGTFVIEYVGEVLDEKEFKRRMKEYAReGNRHYYFMALK---------SDE---IIDATKK 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1002238373 655 GNVARFINHRCfDANiigipveIETPD---HHYYHLAFFTTRIIEPFEELTWDYGIDfddvDHPVKAFKCHCGSEFCR 729
Cdd:cd19172    73 GNLSRFINHSC-EPN-------CETQKwtvNGELRVGFFAKRDIPAGEELTFDYQFE----RYGKEAQKCYCGSPNCR 138
SET_SETD2-like cd10531
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...
 574-729 5.32e-26

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.


Pssm-ID: 380929  Cd Length: 136  Bit Score: 103.87  E-value: 5.32e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 574 LQVFLTpEKKGWGLRSTEKLPRGAFVCEYVGEILTNIELYDRTI-QKTGKAKHTYPLLLDADwgtegvlkdeeaLCLDAT 652
Cdd:cd10531     2 LELFRT-EKKGWGVKAKEDIQKGEFIIEYVGEVIDKKEFKERLDeYEELGKSNFYILSLSDD------------VVIDAT 68

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1002238373 653 FYGNVARFINHRCfDANiigipVEIE-TPDHHYYHLAFFTTRIIEPFEELTWDYGidfdDVDHPVKAFKCHCGSEFCR 729
Cdd:cd10531    69 RKGNLSRFINHSC-EPN-----CETQkWIVNGEYRIGIFALRDIPAGEELTFDYN----FVNYNEAKQVCLCGAQNCR 136
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 573-729 4.99e-25

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 101.21  E-value: 4.99e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 573 HLQVFLTPEKkGWGLRSTEKLPRGAFVCEYVGEILTNIELYDRTIQKTGKAKHTYPLLLDadwgtEGVLkdeealcLDAT 652
Cdd:cd19174     1 GLERFRTEDK-GWGVRTKEPIKAGQFIIEYVGEVVSEQEFRRRMIEQYHNHSHHYCLNLD-----SGMV-------IDGY 67

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1002238373 653 FYGNVARFINHRCfDANiigipVEIETPD-HHYYHLAFFTTRIIEPFEELTWDYgiDFDDVDhPVKAFKCHCGSEFCR 729
Cdd:cd19174    68 RMGNEARFVNHSC-DPN-----CEMQKWSvNGVYRIGLFALKDIPAGEELTYDY--NFHSFN-VEKQQPCKCGSPNCR 136
WIYLD pfam10440
Ubiquitin-binding WIYLD domain; This presumed domain has been predicted to contain three alpha ...
 24-80 1.17e-22

Ubiquitin-binding WIYLD domain; This presumed domain has been predicted to contain three alpha helices. The domain was named the WIYLD domain based on the pattern of most conserved residues. It binds ubiquitin. In the Arabidopsis thaliana histone-lysine N-methyltransferase SUVR4, binding of ubiquitin to this domain stimulates enzymatic activity and converts its activity from a strict dimethylase to a di/trimethylase.


Pssm-ID: 431288  Cd Length: 58  Bit Score: 91.54  E-value: 1.17e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1002238373  24 KDRFDAAIRAMADIGILKETAAPVLNNLLNLFDYNWVHIEADNYLALADAIFCDSDP 80
Cdd:pfam10440   2 DRRIDAAIDAMRPLGIPKEKIRPVLKNLLKVYGGNWPLIEEDNYRVLADAIFEKQDE 58
SET_SETD1-like cd10518
SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), ...
 584-729 2.88e-22

SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), histone-lysine N-methyltransferases (KMT2A/KMT2B/KMT2C/KMT2D) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A), 1B (SETD1B), as well as histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B), 2C (KMT2C), 2D (KMT2D). These proteins are histone-lysine N-methyltransferases (EC 2.1.1.43) that specifically methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380916  Cd Length: 150  Bit Score: 93.43  E-value: 2.88e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 584 GWGLRSTEKLPRGAFVCEYVGEILTNI--ELYDRTIQKTGkAKHTYPLLLDADWgtegvlkdeealCLDATFYGNVARFI 661
Cdd:cd10518    25 GWGLFAKRPIAAGEMVIEYVGEVIRPIvaDKREKRYDEEG-GGGTYMFRIDEDL------------VIDATKKGNIARFI 91

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1002238373 662 NHRCfDANIIGIPVEIETPDhhyyHLAFFTTRIIEPFEELTWDYGIDFDDvdhpVKAFKCHCGSEFCR 729
Cdd:cd10518    92 NHSC-DPNCYAKIITVDGEK----HIVIFAKRDIAPGEELTYDYKFPIED----EEKIPCLCGAPNCR 150
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 584-706 1.61e-20

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 87.58  E-value: 1.61e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 584 GWGLRSTEKLPRGAFVCEYVGEILTNIELYDR---TIQKTGKAKHTYPLLLDadwgtegvLKDEEALCLDAT--FYGNVA 658
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVLLITKEEADKrelLYYDKLELRLWGPYLFT--------LDEDSEYCIDARalYYGNWA 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1002238373 659 RFINHRCfDANIIGIPVEIETpdhhYYHLAFFTTRIIEPFEELTWDYG 706
Cdd:pfam00856  73 RFINHSC-DPNCEVRVVYVNG----GPRIVIFALRDIKPGEELTIDYG 115
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
581-729 1.30e-19

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 85.40  E-value: 1.30e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 581 EKKGWGLRSTEKLPRGAFVCEYVGEILTNIELYDRTIQKTgkAKHTYPLLLDADWGtegvlkdeealcLDATFYGNVARF 660
Cdd:COG2940    14 PIHGRGVFATRDIPKGTLIGEYPGEVITWAEAERREPHKE--PLHTYLFELDDDGV------------IDGALGGNPARF 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1002238373 661 INHRCfDANiigipVEIETPDHHYYhlaFFTTRIIEPFEELTWDYGIDFDDvdhpvKAFKCHCGSefCR 729
Cdd:COG2940    80 INHSC-DPN-----CEADEEDGRIF---IVALRDIAAGEELTYDYGLDYDE-----EEYPCRCPN--CR 132
SET_ASHR3-like cd19175
SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 ...
 581-731 1.20e-17

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins; This family includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3, also termed protein SET DOMAIN GROUP 4 or protein stamen loss), ASH1 homolog 3 (ASHH3, also termed protein SET DOMAIN GROUP 7) and homolog 4 (ASHH4, also termed protein SET DOMAIN GROUP 24). They all function as histone-lysine N-methyltransferases (EC 2.1.1.43).


Pssm-ID: 380952 [Multi-domain]  Cd Length: 139  Bit Score: 80.15  E-value: 1.20e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 581 EKKGWGLRSTEKLPRGAFVCEYVGEILTNIELYDR--TIQKTGKaKHTYPLLLDADwgtegvlkdeeaLCLDATFYGNVA 658
Cdd:cd19175     8 EKCGWGLVADEDINAGEFIIEYVGEVIDDKTCEERlwDMKHKGE-KNFYMCEIDKD------------MVIDATFKGNLS 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002238373 659 RFINHRCfDANII--GIPVEIETpdhhyyHLAFFTTRIIEPFEELTWDYG-IDF-DDVDhpvkafkCHCGSEFCRDK 731
Cdd:cd19175    75 RFINHSC-DPNCElqKWQVDGET------RIGVFAIRDIKKGEELTYDYQfVQFgADQD-------CHCGSKNCRGK 137
Pre-SET pfam05033
Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines ...
 407-564 9.53e-16

Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilising SET domains.


Pssm-ID: 461530 [Multi-domain]  Cd Length: 99  Bit Score: 73.22  E-value: 9.53e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 407 ITKGEERLRIPIINEYGNGILPPPFHYIPHNITLQEAYVNISlarigddNCCsDCfRDClaQSLPCACAAETGGE--FAY 484
Cdd:pfam05033   1 ISKGKENVPIPVVNEVDDEPPPPDFTYITSYIYPKEFLLIIP-------QGC-DC-GDC--SSEKCSCAQLNGGEfrFPY 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 485 TTDGLLKgafldscismireplkhphfyckicpnermkievnsdssntemnpgpckgHLTRKFIKECWRKCGCTRNCGNR 564
Cdd:pfam05033  70 DKDGLLV--------------------------------------------------PESKPPIYECNPLCGCPPSCPNR 99
SET_NSD cd19173
SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, ...
 574-728 1.70e-15

SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, NSD2, NSD3 and similar proteins; The nuclear receptor-binding SET Domain (NSD) family of histone H3 lysine 36 methyltransferases is comprised of NSD1, NSD2, and NSD3, which are primarily known to be involved in chromatin integrity and gene expression through mono-, di-, or tri-methylating lysine 36 of histone H3 (H3K36), respectively. NSD1 (EC 2.1.1.43; also termed histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B) or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3.


Pssm-ID: 380950 [Multi-domain]  Cd Length: 142  Bit Score: 73.89  E-value: 1.70e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 574 LQVFLTPEKkGWGLRSTEKLPRGAFVCEYVGEILTNIELYDRtIQKTGKAKHT--YPLLLDADwgtegvlkdeeaLCLDA 651
Cdd:cd19173     4 TEPFKTGDR-GWGLRTKRDIKKGDFVIEYVGELIDEEECRRR-LKKAHENNITnfYMLTLDKD------------RIIDA 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 652 TFYGNVARFINHRCfDANiigipveIET------PDHhyyHLAFFTTRIIEPFEELTWDYGIDFDDVDHPVkafkCHCGS 725
Cdd:cd19173    70 GPKGNLSRFMNHSC-QPN-------CETqkwtvnGDT---RVGLFAVRDIPAGEELTFNYNLDCLGNEKKV----CRCGA 134


                  ...
gi 1002238373 726 EFC 728
Cdd:cd19173   135 PNC 137
SET_KMT2C_2D cd19171
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), ...
 583-729 1.90e-15

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; This family includes KMT2C and KMT2D. Both, KMT2C (also termed HALR or MLL3) and KMT2D (also termed ALR or MLL2), act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me). They are subunits of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380948 [Multi-domain]  Cd Length: 153  Bit Score: 74.00  E-value: 1.90e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 583 KGWGLRSTEKLPRGAFVCEYVGEILTNIELYDRTIQKTGKAKHTYPLLLDADWgtegvlkdeealCLDATFYGNVARFIN 662
Cdd:cd19171    24 QGLGLYAARDIEKHTMVIEYIGEIIRNEVANRREKIYESQNRGIYMFRIDNDW------------VIDATMTGGPARYIN 91

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002238373 663 HRCfDANIIGIPVEIETPDhhyyHLAFFTTRIIEPFEELTWDYGIDFDDVDHPVkafKCHCGSEFCR 729
Cdd:cd19171    92 HSC-NPNCVAEVVTFDKEK----KIIIISNRRIAKGEELTYDYKFDFEDDQHKI---PCLCGAPNCR 150
SET_SETD8 cd10528
SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2. ...
 564-706 1.08e-14

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2.1.1.43; also termed N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7 or PR/SET07) is a nucleosomal histone-lysine N-methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). It plays a central role in the silencing of euchromatic genes.


Pssm-ID: 380926 [Multi-domain]  Cd Length: 141  Bit Score: 71.45  E-value: 1.08e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 564 RVVQRGITRHLQVFLTPEKkGWGLRSTEKLPRGAFVCEYVGEILTNIELYDRTI-----QKTGKakhtYPLLLDADwgte 638
Cdd:cd10528     9 ELILSGKEEGLKVIEIDGK-GRGVIATRPFEKGDFVVEYHGDLITITEAKKREAlyakdPSTGC----YMYYFQYK---- 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002238373 639 gvlkdEEALCLDAT----FYGnvaRFINHRCFDANIIGIPVEIETPDHhyyhLAFFTTRIIEPFEELTWDYG 706
Cdd:cd10528    80 -----GKTYCVDATkesgRLG---RLINHSKKKPNLKTKLLVIDGVPH----LILVAKRDIKPGEELLYDYG 139
SET_KMT2A_2B cd19170
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), ...
 584-729 4.79e-13

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins; This family includes KMT2A and KMT2B. Both KMT2A (also termed ALL-1 or CXXC7 or MLL or MLL1 or TRX1 or HRX) and KMT2B (also termed MLL4 or TRX2) act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380947 [Multi-domain]  Cd Length: 152  Bit Score: 67.42  E-value: 4.79e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 584 GWGLRSTEKLPRGAFVCEYVGEILTNIELYDRTIQKTGKAKHTYPLLLDADwgtegvlkdeeaLCLDATFYGNVARFINH 663
Cdd:cd19170    25 GRGLFCKRNIDAGEMVIEYAGEVIRSVLTDKREKYYESKGIGCYMFRIDDD------------EVVDATMHGNAARFINH 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1002238373 664 RCfDANIIGIPVEIETPDhhyyHLAFFTTRIIEPFEELTWDYGIDFDDVDHPvkafkCHCGSEFCR 729
Cdd:cd19170    93 SC-EPNCYSRVVNIDGKK----HIVIFALRRILRGEELTYDYKFPIEDVKIP-----CTCGSKKCR 148
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 583-711 5.76e-13

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 66.21  E-value: 5.76e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 583 KGWGLRSTEKLPRGAFVCEYVGEILTNIElYDRTIQKTGKAkhTYPLLLDADWGTegvlkdeealcLDATFYGNVARFIN 662
Cdd:cd10522    13 NGLGLFAAETIAKGEFVGEYTGEVLDRWE-EDRDSVYHYDP--LYPFDLNGDILV-----------IDAGKKGNLTRFIN 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1002238373 663 HrcfdANIIGIPVeIETPDHHYYHLAFFTTRIIEPFEELTWDYGIDFDD 711
Cdd:cd10522    79 H----SDQPNLEL-IVRTLKGEQHIGFVAIRDIKPGEELFISYGPKYWK 122
SET_SETD1 cd19169
SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and ...
 584-729 6.65e-13

SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A) and SET domain-containing protein 1B (SETD1B). These proteins are histone-lysine N-methyltransferases that specifically methylate 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated.


Pssm-ID: 380946  Cd Length: 148  Bit Score: 66.59  E-value: 6.65e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 584 GWGLRSTEKLPRGAFVCEYVGEILTNI--ELYDRTIQKTGKAKhTYPLLLDADwgtegvlkdeeaLCLDATFYGNVARFI 661
Cdd:cd19169    24 DWGLFALEPIAADEMVIEYVGQVIRQSvaDEREKRYEAIGIGS-SYLFRVDDD------------TIIDATKCGNLARFI 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1002238373 662 NHRCfDANIIGIPVEIETpdhhYYHLAFFTTRIIEPFEELTWDYGIDFDDVDHPvkafkCHCGSEFCR 729
Cdd:cd19169    91 NHSC-NPNCYAKIITVES----QKKIVIYSKRPIAVNEEITYDYKFPIEDEKIP-----CLCGAPQCR 148
SET_EZH cd10519
SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar ...
 584-706 8.88e-13

SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both, EZH1 and EZH2, can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380917  Cd Length: 117  Bit Score: 65.34  E-value: 8.88e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 584 GWGLRSTEKLPRGAFVCEYVGEILTNIE------LYDRtiqktgkAKHTYPLLLDADWgtegvlkdeealCLDATFYGNV 657
Cdd:cd10519    12 GWGLFLKEPIKKDEFIGEYTGELISQDEadrrgkIYDK-------YNSSYLFNLNDQF------------VVDATRKGNK 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1002238373 658 ARFINHRCfDANIIGiPVEIETPDHhyyHLAFFTTRIIEPFEELTWDYG 706
Cdd:cd10519    73 IRFANHSS-NPNCYA-KVMMVNGDH---RIGIFAKRDIEAGEELFFDYG 116
SET_EZH-like cd19168
SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb ...
 584-709 2.21e-12

SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb repressive complex 2 (PRC2), and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both EZH1 and EZH2 can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380945  Cd Length: 124  Bit Score: 64.52  E-value: 2.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 584 GWGLRSTEKLPRGAFVCEYVGEILTNIELYDRTiQKTGKAKHTYPLLLDADWGtegvlkdeealcLDATFYGNVARFINH 663
Cdd:cd19168    13 GLGLFAAEDIKEGEFVIEYTGELISHDEGVRRE-HRRGDVSYLYLFEEQEGIW------------VDAAIYGNLSRYINH 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1002238373 664 RCFDANIIGIPVEIeTPDHHYYHLAFFTTRIIEPFEELTWDYGIDF 709
Cdd:cd19168    80 ATDKVKTGNCMPKI-MYVNHEWRIKFTAIKDIKIGEELFFNYGDNF 124
SET_SET1 cd20072
SET domain (including post-SET domain) found in catalytic component of the Saccharomyces ...
 585-729 3.26e-12

SET domain (including post-SET domain) found in catalytic component of the Saccharomyces cerevisiae COMPASS complex and similar proteins; The family contains mostly fungal SET domains, including SET1 found in the catalytic component of the Saccharomyces cerevisiae COMPASS (complex of proteins associated with Set1). SET1 is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex. The activity of this catalytic domain is established through forming a complex with a set of core proteins; it is extensively contacted by Cps60 (Bre2), Cps50 (Swd1), and Cps30 (Swd3).


Pssm-ID: 380998  Cd Length: 148  Bit Score: 64.75  E-value: 3.26e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 585 WGLRSTEKLPRGAFVCEYVGEIL--TNIELYDRTIQKTGKAKhTYPLLLDADwgtegvlkdeeaLCLDATFYGNVARFIN 662
Cdd:cd20072    25 WGLYAMENISAKDMVIEYVGEVIrqQVADEREKRYLRQGIGS-SYLFRIDDD------------TVVDATKKGNIARFIN 91

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002238373 663 HRCfDANIIGIPVEIETPDhhyyHLAFFTTRIIEPFEELTWDYGIDFDDVDHPvkafkCHCGSEFCR 729
Cdd:cd20072    92 HCC-DPNCTAKIIKVEGEK----RIVIYAKRDIAAGEELTYDYKFPREEDKIP-----CLCGAPNCR 148
SET_KMT2A cd19206
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) ...
 584-729 7.12e-11

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) and similar proteins; KMT2A (EC2.1.1.43; also termed lysine N-methyltransferase 2A, ALL-1, CXXC-type zinc finger protein 7 (CXXC7), myeloid/lymphoid or mixed-lineage leukemia (MLL), myeloid/lymphoid or mixed-lineage leukemia protein 1 (MLL1), trithorax-like protein (TRX1), or zinc finger protein HRX) acts as a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac).


Pssm-ID: 380983 [Multi-domain]  Cd Length: 154  Bit Score: 61.19  E-value: 7.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 584 GWGLRSTEKLPRGAFVCEYVGEILTNIELYDRTIQKTGKAKHTYPLLLDadwgtegvlkDEEALclDATFYGNVARFINH 663
Cdd:cd19206    25 GRGLFCKRNIDAGEMVIEYSGNVIRSILTDKREKYYDSKGIGCYMFRID----------DSEVV--DATMHGNAARFINH 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1002238373 664 RCfDANIIGIPVEIETPDhhyyHLAFFTTRIIEPFEELTWDYGIDFDDvdhPVKAFKCHCGSEFCR 729
Cdd:cd19206    93 SC-EPNCYSRVINIDGQK----HIVIFAMRKIYRGEELTYDYKFPIED---ASNKLPCNCGAKKCR 150
SET_NSD2 cd19211
SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) ...
 581-728 3.79e-10

SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins; NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-36' (H3K36me) methyltransferase activity. NSD2 has been shown to mediate di- and trimethylation of H3K36 and dimethylation of H4K20 in different systems, and has been characterized as a transcriptional repressor interacting with histone deacetylase HDAC1 and histone demethylase LSD1. NSD2 mediates constitutive NF-kappaB signaling for cancer cell proliferation, survival and tumor growth. It is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumor aggressiveness. WHSC1 is frequently deleted in Wolf-Hirschhorn syndrome (WHS).


Pssm-ID: 380988 [Multi-domain]  Cd Length: 142  Bit Score: 58.85  E-value: 3.79e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 581 EKKGWGLRSTEKLPRGAFVCEYVGEILTNIELYDRT-IQKTGKAKHTYPLLLDADwgtegvlkdeeaLCLDATFYGNVAR 659
Cdd:cd19211    10 EGKGWGLIAKRDIKKGEFVNEYVGELIDEEECMARIkHAHENDITHFYMLTIDKD------------RIIDAGPKGNYSR 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 660 FINHRCF-DANIIGIPVEIETpdhhyyHLAFFTTRIIEPFEELTWDYGIDFDDVDHPVkafkCHCGSEFC 728
Cdd:cd19211    78 FMNHSCQpNCETQKWTVNGDT------RVGLFAVCDIPAGTELTFNYNLDCLGNEKTV----CRCGAPNC 137
SET_KMT2D cd19209
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) ...
 583-729 1.12e-09

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins; KMT2D (EC2.1.1.43; also termed lysine N-methyltransferase 2D, ALL1-related protein (ALR), or myeloid/lymphoid or mixed-lineage leukemia protein 2 (MLL2)), acts as histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. KMT2D is a subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380986 [Multi-domain]  Cd Length: 155  Bit Score: 57.78  E-value: 1.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 583 KGWGLRSTEKLPRGAFVCEYVGEILTNIELYDRTIQKTGKAKHTYPLLLDADWgtegvlkdeealCLDATFYGNVARFIN 662
Cdd:cd19209    26 QGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIYEEQNRGIYMFRINNEH------------VIDATLTGGPARYIN 93

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002238373 663 HRCfDANIIGIPVEIETPDHhyyhLAFFTTRIIEPFEELTWDYGIDFDDVDHPVkafKCHCGSEFCR 729
Cdd:cd19209    94 HSC-APNCVAEVVTFDKEDK----IIIISSRRIPKGEELTYDYQFDFEDDQHKI---PCHCGAWNCR 152
SET_KMT2C cd19208
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) ...
 583-729 1.34e-09

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) and similar proteins; KMT2C (EC2.1.1.43; also termed lysine N-methyltransferase 2C, homologous to ALR protein (HALR) myeloid/lymphoid, or mixed-lineage leukemia protein 3 (MLL3)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me) and may be involved in leukemogenesis and developmental disorder. KMT2C is a catalytic subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. Overexpression of KMT2C is associated with estrogen receptor-positive breast cancer; KMT2C mediates the estrogen dependence of breast cancer through regulation of estrogen receptor alpha (ERalpha) enhancer function. KMT2C is frequently mutated in certain populations with diffuse-type gastric adenocarcinomas (DGA); its loss promotes epithelial-to-mesenchymal transition (EMT) and is associated with worse overall survival.


Pssm-ID: 380985 [Multi-domain]  Cd Length: 154  Bit Score: 57.33  E-value: 1.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 583 KGWGLRSTEKLPRGAFVCEYVGEILTNiELYDRTIQ-KTGKAKHTYPLLLDADWgtegvlkdeealCLDATFYGNVARFI 661
Cdd:cd19208    25 QGLGLYAARDIEKHTMVIEYIGTIIRN-EVANRKEKlYESQNRGVYMFRIDNDH------------VIDATLTGGPARYI 91

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1002238373 662 NHRCfDANIIGIPVEIETPdhhyYHLAFFTTRIIEPFEELTWDYGIDFDDVDHPVkafKCHCGSEFCR 729
Cdd:cd19208    92 NHSC-APNCVAEVVTFEKG----HKIIISSSRRIQKGEELCYDYKFDFEDDQHKI---PCHCGAVNCR 151
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 657-706 3.89e-09

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 53.41  E-value: 3.89e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1002238373 657 VARFINHRCfDANIIGIPVEIETPdhhyYHLAFFTTRIIEPFEELTWDYG 706
Cdd:cd08161    28 LARFINHSC-EPNCEFEEVYVGGK----PRVFIVALRDIKAGEELTVDYG 72
SET_SETD5-like cd10529
SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine ...
 586-710 4.89e-09

SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. KMT2E (also termed inactive lysine N-methyltransferase 2E or myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. The family also includes Saccharomyces cerevisiae SET domain-containing proteins, SET3 and SET4, and Schizosaccharomyces pombe SET3. Most of these family members contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380927  Cd Length: 127  Bit Score: 54.97  E-value: 4.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 586 GLRSTEKLPRGAFVCEYVGEILTNIELydRTIQKTGKAKHTYPLLLDADWGTEgvlkdeeaLCLDATFYGNVARFINHRC 665
Cdd:cd10529    18 GLVATEDISPGEPILEYKGEVSLRSEF--KEDNGFFKRPSPFVFFYDGFEGLP--------LCVDARKYGNEARFIRRSC 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1002238373 666 fDANiigipVEIetpdHHYY------HLAFFTTRIIEPFEELTwdygIDFD 710
Cdd:cd10529    88 -RPN-----AEL----RHVVvsngelRLFIFALKDIRKGTEIT----IPFD 124
SET_NSD1 cd19210
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 573-665 8.72e-09

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins; NSD1 (EC 2.1.1.43; also termed Histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD1 is altered in approximately 10% of head and neck cancer patients with 55% decrease in risk of death in NSD1-mutated versus non-mutated patients; its disruption promotes favorable chemotherapeutic responses linked to hypomethylation.


Pssm-ID: 380987 [Multi-domain]  Cd Length: 142  Bit Score: 54.55  E-value: 8.72e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 573 HLQVFLTPEKkGWGLRSTEKLPRGAFVCEYVGEILTNIELYDRT-IQKTGKAKHTYPLLLDADwgtegvlkdeeaLCLDA 651
Cdd:cd19210     3 EVEIFRTLGR-GWGLRCKTDIKKGEFVNEYVGELIDEEECRARIrYAQEHDITNFYMLTLDKD------------RIIDA 69

                          90
                  ....*....|....
gi 1002238373 652 TFYGNVARFINHRC 665
Cdd:cd19210    70 GPKGNYARFMNHCC 83
SET_KMT2B cd19207
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) ...
 584-729 1.86e-08

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) and similar proteins; KMT2B (EC2.1.1.43; also termed lysine N-methyltransferase 2B, myeloid/lymphoid or mixed-lineage leukemia protein 4 (MLL2/MLL4), trithorax homolog 2 (TRX2), or WW domain-binding protein 7 (WBP-7)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that precedes resumption of meiosis, oocyte survival and normal zygotic genome activation.


Pssm-ID: 380984 [Multi-domain]  Cd Length: 154  Bit Score: 54.26  E-value: 1.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 584 GWGLRSTEKLPRGAFVCEYVGEILTNIELYDRTIQKTGKAKHTYPLLLDadwgtegvlkdeEALCLDATFYGNVARFINH 663
Cdd:cd19207    25 GRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDSKGIGCYMFRID------------DFDVVDATMHGNAARFINH 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1002238373 664 RCfDANIIGIPVEIETPDhhyyHLAFFTTRIIEPFEELTWDYGIDFDDVDHPVkafKCHCGSEFCR 729
Cdd:cd19207    93 SC-EPNCYSRVIHVEGQK----HIVIFALRKIYRGEELTYDYKFPIEDASNKL---PCNCGAKRCR 150
PreSET smart00468
N-terminal to some SET domains; A Cys-rich putative Zn2+-binding domain that occurs N-terminal ...
 406-490 3.26e-08

N-terminal to some SET domains; A Cys-rich putative Zn2+-binding domain that occurs N-terminal to some SET domains. Function is unknown. Unpublished.


Pssm-ID: 128744 [Multi-domain]  Cd Length: 98  Bit Score: 51.65  E-value: 3.26e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373  406 DITKGEERLRIPIINEYGNGILPPPFHYIPHNITLQEAyvnISLARIGDDNCCSdCFRDCLAqSLPCACAAETGGEFAYT 485
Cdd:smart00468   3 DISNGKENVPVPLVNEVDEDPPPPDFEYISEYIYGQGV---PIDRSPSPLVGCS-CSGDCSS-SNKCECARKNGGEFAYE 77


                   ....*
gi 1002238373  486 TDGLL 490
Cdd:smart00468  78 LNGGL 82
SET_SpSET3-like cd19183
SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET ...
 586-719 4.77e-08

SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET domain-containing protein 3 (SETD3) and similar proteins; Schizosaccharomyces pombe SETD3 functions as a transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. It is required for both, gene activation and repression.


Pssm-ID: 380960  Cd Length: 173  Bit Score: 53.18  E-value: 4.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 586 GLRSTEKLPRGAFVCEYVGEIltniELYDRTIQKTgkaKHTYPLL--------LDADWgtegvlkdeeALCLDATFYGNV 657
Cdd:cd19183    15 GLFADRPIPAGDPIQELLGEI----GLQSEYIADP---ENQYQILgapkphvfFHPQS----------PLYIDTRRSGSV 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002238373 658 ARFINHRCfDANIIGIPVEIEtpDHHYYHLAFFTTRIIEPFEELTWDYGIDFddvDHPVKAF 719
Cdd:cd19183    78 ARFIRRSC-RPNAELVTVASD--SGSVLKFVLYASRDISPGEEITIGWDWDN---PHPFRRF 133
SET_SETD1A cd19204
SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and ...
 585-729 5.09e-08

SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and similar proteins; SETD1A (EC2.1.1.43), also termed lysine N-methyltransferase 2F, or Set1/Ash2 histone methyltransferase complex subunit SET1, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Human SET domain containing protein 1A (hSETD1A) expression occurs at a high rate in hepatocellular carcinoma patients and controls tumor metastasis in breast cancer by activating MMP expression.


Pssm-ID: 380981 [Multi-domain]  Cd Length: 153  Bit Score: 52.72  E-value: 5.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 585 WGLRSTEKLPRGAFVCEYVGEILTNI--ELYDRTIQKTGKAKhTYPLLLDADwgtegvlkdeeaLCLDATFYGNVARFIN 662
Cdd:cd19204    26 WGLFAMEPIAADEMVIEYVGQNIRQVvaDMREKRYVQEGIGS-SYLFRVDHD------------TIIDATKCGNLARFIN 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002238373 663 HrCFDANIIGIPVEIETPDhhyyHLAFFTTRIIEPFEELTWDYGIDFDDVDHPvkafkCHCGSEFCR 729
Cdd:cd19204    93 H-CCTPNCYAKVITIESQK----KIVIYSKQPIGVNEEITYDYKFPIEDNKIP-----CLCGTENCR 149
SET_NSD3 cd19212
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 581-728 9.24e-08

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 3 (NSD3) and similar proteins; NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. NSD3 is amplified and overexpressed in multiple cancer types, including acute myeloid leukemia (AML), breast, lung, pancreatic and bladder cancers, as well as squamous cell carcinoma of the head and neck (SCCHN). NSD3 contributes to tumorigenesis by interacting with bromodomain-containing protein 4 (BRD4), the bromodomain and extraterminal (BET) protein, which is a potential therapeutic target in acute myeloid leukemia (AML). NSD3 is amplified in primary tumors and cell lines from breast carcinoma, and can promote the cell viability of small-cell lung cancer and pancreatic ductal adenocarcinoma. High NSD3 expression is implicated in poor grade and heavy smoking history in SCCHN. Thus, NSD3 may serve as a potential druggable target for selective cancer therapy.


Pssm-ID: 380989 [Multi-domain]  Cd Length: 142  Bit Score: 51.85  E-value: 9.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 581 EKKGWGLRSTEKLPRGAFVCEYVGEILTNIELYDRtIQKTGKAKHTYPLLLDadwgtegVLKDEealCLDATFYGNVARF 660
Cdd:cd19212    10 ERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLR-IKRAHENSVTNFYMLT-------VTKDR---IIDAGPKGNYSRF 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1002238373 661 INHRCfDANiigipveIETPD---HHYYHLAFFTTRIIEPFEELTWDYGIDFDDVDHPvkafKCHCGSEFC 728
Cdd:cd19212    79 MNHSC-NPN-------CETQKwtvNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRT----ECHCGADNC 137
SET_SETD1B cd19205
SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and ...
 585-729 2.12e-07

SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and similar proteins; SETD1B (EC2.1.1.43), also termed lysine N-methyltransferase 2G, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Loss of SETD1B occurs in up to half the gastric and colorectal cancers, most commonly via SETD1B mutations, while de novo variants in SETD1B are associated with intellectual disability, epilepsy and autism.


Pssm-ID: 380982 [Multi-domain]  Cd Length: 153  Bit Score: 51.21  E-value: 2.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 585 WGLRSTEKLPRGAFVCEYVGEiltNIElydRTIQKTGKAKHTyplllDADWGTEGVLKDEEALCLDATFYGNVARFINHR 664
Cdd:cd19205    26 WGLFAMEPIAADEMVIEYVGQ---NIR---QVIADMREKRYE-----DEGIGSSYMFRVDHDTIIDATKCGNFARFINHS 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1002238373 665 CfDANIIGIPVEIETPDhhyyHLAFFTTRIIEPFEELTWDYGIDFDDVDHPvkafkCHCGSEFCR 729
Cdd:cd19205    95 C-NPNCYAKVITVESQK----KIVIYSKQHINVNEEITYDYKFPIEDVKIP-----CLCGSENCR 149
SET_EZH1 cd19217
SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43) ...
 567-705 8.77e-07

SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43), also termed ENX-2, or histone-lysine N-methyltransferase EZH1, is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380994  Cd Length: 136  Bit Score: 48.91  E-value: 8.77e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 567 QRGITRHLqvFLTP-EKKGWGLRSTEKLPRGAFVCEYVGEILTNIELyDRTIQKTGKAKHTYPLLLDADWgtegvlkdee 645
Cdd:cd19217     1 QRGLKKHL--LLAPsDVAGWGTFIKESVQKNEFISEYCGELISQDEA-DRRGKVYDKYMSSFLFNLNNDF---------- 67

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1002238373 646 alCLDATFYGNVARFINH----RCFdANIIGIpveieTPDHhyyHLAFFTTRIIEPFEELTWDY 705
Cdd:cd19217    68 --VVDATRKGNKIRFANHsvnpNCY-AKVVMV-----NGDH---RIGIFAKRAIQQGEELFFDY 120
SET_EZH2 cd19218
SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43) ...
 569-705 1.69e-06

SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43), also termed lysine N-methyltransferase 6, or ENX-1, or histone-lysine N-methyltransferase EZH2, is a catalytic subunit of the polycomb repressive complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380995  Cd Length: 120  Bit Score: 47.60  E-value: 1.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002238373 569 GITRHLqvFLTPEK-KGWGLRSTEKLPRGAFVCEYVGEILTNIELyDRTIQKTGKAKHTYPLLLDADWgtegvlkdeeal 647
Cdd:cd19218     1 GSKKHL--LLAPSDvAGWGIFIKDPVQKNEFISEYCGEIISQDEA-DRRGKVYDKYMCSFLFNLNNDF------------ 65

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002238373 648 CLDATFYGNVARFINH----RCFdaniigIPVEIETPDHhyyHLAFFTTRIIEPFEELTWDY 705
Cdd:cd19218    66 VVDATRKGNKIRFANHsvnpNCY------AKVMMVNGDH---RIGIFAKRAIQTGEELFFDY 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH