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Conserved domains on  [gi|1002239142|ref|XP_015623804|]
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uncharacterized protein [Oryza sativa Japonica Group]

Protein Classification

OTU family ubiquitin thioesterase( domain architecture ID 17784707)

OTU family ubiquitin thioesterase catalyzes the thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin

CATH:  1.20.1300.20|3.30.200.60
EC:  3.4.19.12
Gene Ontology:  GO:0004843
MEROPS:  C65
PubMed:  10664582|23827681|12704427|31884527
SCOP:  4004307

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Otubain_C65 cd22749
Otubain subfamily of ubiquitin thioesterases; The otubain subfamily is composed of otubain-1 ...
 167-404 4.98e-52

Otubain subfamily of ubiquitin thioesterases; The otubain subfamily is composed of otubain-1 (also called ubiquitin thioesterase OTUB1 or OTU domain-containing ubiquitin aldehyde-binding protein 1), otubain-2 (also called ubiquitin thioesterase OTUB2 or OTU domain-containing ubiquitin aldehyde-binding protein 2), and similar proteins. They function as deubiquitylases (DUBs)/ubiquitin thioesterases (EC 3.4.19.12). OTUB1 can specifically remove 'Lys-48'-linked conjugated ubiquitin from protein substrates, while OTUB2 mediates the deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains. The otubain subfamily belongs to the OTU family of cysteine proteases that use a conserved cysteine, histidine, and an aspartate, as the catalytic triad. Members of this subfamily are classified as family C65 cysteine proteases by MEROPS.


:

Pssm-ID: 438586 [Multi-domain]  Cd Length: 232  Bit Score: 180.99  E-value: 4.98e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002239142 167 HKKIPMGEAANHYFRNidNSFQQpevglRLKYLSHHYSEFRPVHRDEECFYRSFIFSYLEQVVDSIGTREEDRLLAAVRA 246
Cdd:cd22749     3 GEKEPLSALAEEYAGN--PIFLQ-----KIKELKKKYSGFRRVRGDGNCFYRAFAFSYLELLLKNQDPAELERLLARLES 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002239142 247 LATKAENLQWA-SEFSQKHKAFERLIEKIKGWKRmqehpISIIRGKILEFFSSYDTTDDIFAFLRLVAATWMCTRIWNYE 325
Cdd:cd22749    76 LKNLLEALGFEeLVFEDFYEEFLELLKKLRNSKE-----RELTEEELLELFNDEETSNYIVVFLRLLTSAYLKTNADDYE 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002239142 326 WcatNCGENQNLEDWCSKHVIAPRVYATSAAVKACAEALRVTVQVENV--HDGTCESTHYIVRG----APCVTLLRIESH 399
Cdd:cd22749   151 P---FLFEGMSVEEFCEREVEPMGKEADHLQITALANALGVPVRVEYLdrSAGGEVNFHEFPPEdsdsLPVITLLYRPGH 227


                  ....*
gi 1002239142 400 YDIIY 404
Cdd:cd22749   228 YDILY 232
 
Name Accession Description Interval E-value
Otubain_C65 cd22749
Otubain subfamily of ubiquitin thioesterases; The otubain subfamily is composed of otubain-1 ...
 167-404 4.98e-52

Otubain subfamily of ubiquitin thioesterases; The otubain subfamily is composed of otubain-1 (also called ubiquitin thioesterase OTUB1 or OTU domain-containing ubiquitin aldehyde-binding protein 1), otubain-2 (also called ubiquitin thioesterase OTUB2 or OTU domain-containing ubiquitin aldehyde-binding protein 2), and similar proteins. They function as deubiquitylases (DUBs)/ubiquitin thioesterases (EC 3.4.19.12). OTUB1 can specifically remove 'Lys-48'-linked conjugated ubiquitin from protein substrates, while OTUB2 mediates the deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains. The otubain subfamily belongs to the OTU family of cysteine proteases that use a conserved cysteine, histidine, and an aspartate, as the catalytic triad. Members of this subfamily are classified as family C65 cysteine proteases by MEROPS.


Pssm-ID: 438586 [Multi-domain]  Cd Length: 232  Bit Score: 180.99  E-value: 4.98e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002239142 167 HKKIPMGEAANHYFRNidNSFQQpevglRLKYLSHHYSEFRPVHRDEECFYRSFIFSYLEQVVDSIGTREEDRLLAAVRA 246
Cdd:cd22749     3 GEKEPLSALAEEYAGN--PIFLQ-----KIKELKKKYSGFRRVRGDGNCFYRAFAFSYLELLLKNQDPAELERLLARLES 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002239142 247 LATKAENLQWA-SEFSQKHKAFERLIEKIKGWKRmqehpISIIRGKILEFFSSYDTTDDIFAFLRLVAATWMCTRIWNYE 325
Cdd:cd22749    76 LKNLLEALGFEeLVFEDFYEEFLELLKKLRNSKE-----RELTEEELLELFNDEETSNYIVVFLRLLTSAYLKTNADDYE 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002239142 326 WcatNCGENQNLEDWCSKHVIAPRVYATSAAVKACAEALRVTVQVENV--HDGTCESTHYIVRG----APCVTLLRIESH 399
Cdd:cd22749   151 P---FLFEGMSVEEFCEREVEPMGKEADHLQITALANALGVPVRVEYLdrSAGGEVNFHEFPPEdsdsLPVITLLYRPGH 227


                  ....*
gi 1002239142 400 YDIIY 404
Cdd:cd22749   228 YDILY 232
Peptidase_C65 pfam10275
Peptidase C65 Otubain; This family of proteins conserved from plants to humans is a highly ...
 180-405 3.83e-22

Peptidase C65 Otubain; This family of proteins conserved from plants to humans is a highly specific ubiquitin iso-peptidase that removes ubiquitin from proteins. The modification of cellular proteins by ubiquitin (Ub) is an important event that underlies protein stability and function in eukaryote being a dynamic and reversible process. Otubain carries several key conserved domains: (i) the OTU (ovarian tumour domain) in which there is an active cysteine protease triad (ii) a nuclear localization signal, (iii) a Ub interaction motif (UIM)-like motif phi-xx-A-xxxs-xx-Ac (where phi indicates an aromatic amino acid, x indicates any amino acid and Ac indicates an acidic amino acid), (iv) a Ub-associated (UBA)-like domain and (v) the LxxLL motif.


Pssm-ID: 431191 [Multi-domain]  Cd Length: 240  Bit Score: 96.19  E-value: 3.83e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002239142 180 FRNIDNSFQQpevglRLKYLSHHYSEFRPVHRDEECFYRSFIFSYLEQVVDSigTREEDRLLAAVRALATKAENLQWASE 259
Cdd:pfam10275  22 YAKADPIYLQ-----KIQDLSEKYSGIRRTRGDGNCFYRAFGFSYLELLLES--KDEIDRFKARVESLKEALVALGFDED 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002239142 260 FSQK-HKAFERLIEKIkgwkrmqEHPISIIRGKILEFFSSYDTTDDIFAFLRLVAATWMCTRIWNYEWCATncgENQNLE 338
Cdd:pfam10275  95 TFEDfCDAFLELLKKV-------EDGVSTSESELLQAFNDQETSDYIVYFLRLLTSAYLKTHADEYEPFID---GGGTVE 164

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002239142 339 DWCSKHVIAPRVYATSAAVKACAEALRVTVQVENVhDGTCE---STHYIVRG-------APCVTLLRIESHYDIIYP 405
Cdd:pfam10275 165 EFCQQEVEPMNKEADHLQIIALAEALGVPVRVEYL-DRSAEgntVNHHDFPGeddteeqAPFITLLYRPGHYDILYK 240
 
Name Accession Description Interval E-value
Otubain_C65 cd22749
Otubain subfamily of ubiquitin thioesterases; The otubain subfamily is composed of otubain-1 ...
 167-404 4.98e-52

Otubain subfamily of ubiquitin thioesterases; The otubain subfamily is composed of otubain-1 (also called ubiquitin thioesterase OTUB1 or OTU domain-containing ubiquitin aldehyde-binding protein 1), otubain-2 (also called ubiquitin thioesterase OTUB2 or OTU domain-containing ubiquitin aldehyde-binding protein 2), and similar proteins. They function as deubiquitylases (DUBs)/ubiquitin thioesterases (EC 3.4.19.12). OTUB1 can specifically remove 'Lys-48'-linked conjugated ubiquitin from protein substrates, while OTUB2 mediates the deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains. The otubain subfamily belongs to the OTU family of cysteine proteases that use a conserved cysteine, histidine, and an aspartate, as the catalytic triad. Members of this subfamily are classified as family C65 cysteine proteases by MEROPS.


Pssm-ID: 438586 [Multi-domain]  Cd Length: 232  Bit Score: 180.99  E-value: 4.98e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002239142 167 HKKIPMGEAANHYFRNidNSFQQpevglRLKYLSHHYSEFRPVHRDEECFYRSFIFSYLEQVVDSIGTREEDRLLAAVRA 246
Cdd:cd22749     3 GEKEPLSALAEEYAGN--PIFLQ-----KIKELKKKYSGFRRVRGDGNCFYRAFAFSYLELLLKNQDPAELERLLARLES 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002239142 247 LATKAENLQWA-SEFSQKHKAFERLIEKIKGWKRmqehpISIIRGKILEFFSSYDTTDDIFAFLRLVAATWMCTRIWNYE 325
Cdd:cd22749    76 LKNLLEALGFEeLVFEDFYEEFLELLKKLRNSKE-----RELTEEELLELFNDEETSNYIVVFLRLLTSAYLKTNADDYE 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002239142 326 WcatNCGENQNLEDWCSKHVIAPRVYATSAAVKACAEALRVTVQVENV--HDGTCESTHYIVRG----APCVTLLRIESH 399
Cdd:cd22749   151 P---FLFEGMSVEEFCEREVEPMGKEADHLQITALANALGVPVRVEYLdrSAGGEVNFHEFPPEdsdsLPVITLLYRPGH 227


                  ....*
gi 1002239142 400 YDIIY 404
Cdd:cd22749   228 YDILY 232
Peptidase_C65 pfam10275
Peptidase C65 Otubain; This family of proteins conserved from plants to humans is a highly ...
 180-405 3.83e-22

Peptidase C65 Otubain; This family of proteins conserved from plants to humans is a highly specific ubiquitin iso-peptidase that removes ubiquitin from proteins. The modification of cellular proteins by ubiquitin (Ub) is an important event that underlies protein stability and function in eukaryote being a dynamic and reversible process. Otubain carries several key conserved domains: (i) the OTU (ovarian tumour domain) in which there is an active cysteine protease triad (ii) a nuclear localization signal, (iii) a Ub interaction motif (UIM)-like motif phi-xx-A-xxxs-xx-Ac (where phi indicates an aromatic amino acid, x indicates any amino acid and Ac indicates an acidic amino acid), (iv) a Ub-associated (UBA)-like domain and (v) the LxxLL motif.


Pssm-ID: 431191 [Multi-domain]  Cd Length: 240  Bit Score: 96.19  E-value: 3.83e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002239142 180 FRNIDNSFQQpevglRLKYLSHHYSEFRPVHRDEECFYRSFIFSYLEQVVDSigTREEDRLLAAVRALATKAENLQWASE 259
Cdd:pfam10275  22 YAKADPIYLQ-----KIQDLSEKYSGIRRTRGDGNCFYRAFGFSYLELLLES--KDEIDRFKARVESLKEALVALGFDED 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002239142 260 FSQK-HKAFERLIEKIkgwkrmqEHPISIIRGKILEFFSSYDTTDDIFAFLRLVAATWMCTRIWNYEWCATncgENQNLE 338
Cdd:pfam10275  95 TFEDfCDAFLELLKKV-------EDGVSTSESELLQAFNDQETSDYIVYFLRLLTSAYLKTHADEYEPFID---GGGTVE 164

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002239142 339 DWCSKHVIAPRVYATSAAVKACAEALRVTVQVENVhDGTCE---STHYIVRG-------APCVTLLRIESHYDIIYP 405
Cdd:pfam10275 165 EFCQQEVEPMNKEADHLQIIALAEALGVPVRVEYL-DRSAEgntVNHHDFPGeddteeqAPFITLLYRPGHYDILYK 240
OTUB2 cd22764
Ubiquitin Thioesterase Otubain-2; Otubain-2 is also called ubiquitin thioesterase OTUB2, ...
 182-404 1.28e-12

Ubiquitin Thioesterase Otubain-2; Otubain-2 is also called ubiquitin thioesterase OTUB2, deubiquitinating enzyme OTUB2, OTU domain-containing ubiquitin aldehyde-binding protein 2, or ubiquitin-specific-processing protease OTUB2. It is a deubiquitylase (DUB)/ubiquitin thioesterase (EC 3.4.19.12) that mediates the deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains. OTUB2 plays a role in DNA double-strand break (DSB) response (DDR); it enhances RNF8-mediated ubiquitination in an early phase of the DDR and promotes faster DSB repair but suppresses homologous recombination. It also functions as a cancer stemness and metastasis-promoting factor that deubiquitinates and activates the transcriptional regulators YAP/TAZ, which play important roles in development, physiology, and tumorigenesis and are negatively controlled by the Hippo pathway. OTUB2 belongs to the OTU family of cysteine proteases that use a conserved cysteine, histidine, and an aspartate, as the catalytic triad. It is classified as a family C65 cysteine protease by MEROPS.


Pssm-ID: 438601  Cd Length: 222  Bit Score: 67.79  E-value: 1.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002239142 182 NIDNSFQQPEVGLRLKYLSHHYSEFRPVHRDEECFYRSFIFSYLEQVvdsIGTREEdrlLAAVRALATKAENLQWASEFS 261
Cdd:cd22764    11 LLPEHPENPIYQRKLKDLSKRYASIRKTRGDGNCFYRALAFAYLESL---LGNSRE---IQKFKETVLQSKNELLAAGFE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002239142 262 QkhKAFERLIEKIKGWKRMQEHPISIirGKILEFFSSYDTTDDIFAFLRLVAATWMCTRIWNYEWCATncgENQNLEDWC 341
Cdd:cd22764    85 E--HRFRNLFNTFVSVVELVEADGSG--SSLLKAFNDQTTSDSIVQYLRLLTSAFLQNRADFFQHFVE---EGMNIKDFC 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1002239142 342 SKHVIAPRVYATSAAVKACAEALRVTVQVENVHDGTCESTHYIV-RGA-PCVTLLRIESHYDIIY 404
Cdd:cd22764   158 TQEVEPMAMECDHIQITALSQALGIPLQVEYVDEMDTALNHHIFpEGAePSVYLLYKTSHYNILY 222
AtOTU1-like cd22765
Arabidopsis thaliana Deubiquitinating enzyme OTU1 and similar plant proteins; This group ...
 195-404 2.82e-11

Arabidopsis thaliana Deubiquitinating enzyme OTU1 and similar plant proteins; This group contains plant otibain-like proteins including Oryza sativa Japonica group otubain-like deubiquitinase and Arabidopsis thaliana deubiquitinating enzyme OTU1 (AtOTU1), also called OVARIAN TUMOR DOMAIN-containing deubiquitinating enzyme 1 or OTU domain-containing protein 1. It is a deubiquitylase (DUB)/ubiquitin thioesterase (EC 3.4.19.12) that mediates the deubiquitination of protein substrates and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. AtOTU1 shows a preference for Met-1 and 'Lys-48' over 'Lys-63'-linked ubiquitin tetramers as substrates. It belongs to the OTU family of cysteine proteases that use a conserved cysteine, histidine, and an aspartate, as the catalytic triad. It is classified as a family C65 cysteine protease by MEROPS.


Pssm-ID: 438602  Cd Length: 247  Bit Score: 64.30  E-value: 2.82e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002239142 195 RLKYLSHHYSEFRPVHRDEECFYRSFIFSYLEQVVDSIGTREEDRLLAAVRALATKAENLQWAsEFSQKhKAFERLIEKI 274
Cdd:cd22765    26 KIESLGETYGAIRRTRGDGNCFFRSFMFGYLEHLLETQDGAEVRRVLKRIEQCKKKLVDLGYQ-ELVFE-DAMEILVEQL 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002239142 275 KGWKRMQEHPISIirGKILEFFSSYDTTDDIFAFLRLVAATWMCTRIWNYEWCATNCgENQNLEDWCSKHVI-----APR 349
Cdd:cd22765   104 ESIGQGDEESISI--ETLLENMRDDMVSNYVVMFLRFVTSAEIQRRADFFEPFIMGL-SNMTVEQFCRRSVEpmgeeSDH 180

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002239142 350 VYATsaavkACAEALRVTVQV----------ENVHDGTCESTHY-------IVRGAPCVTLLRIESHYDIIY 404
Cdd:cd22765   181 VHIV-----ALTDALQVPIRVvyldrsscdgAGGGAGGVEVNHHdfvpegcPAAGRPRVHLLYRPGHYDILY 247
OTUB1 cd22763
Ubiquitin Thioesterase Otubain-1; Otubain-1 is also called ubiquitin thioesterase OTUB1, ...
 184-404 5.56e-08

Ubiquitin Thioesterase Otubain-1; Otubain-1 is also called ubiquitin thioesterase OTUB1, deubiquitinating enzyme OTUB1, OTU domain-containing ubiquitin aldehyde-binding protein 1, or ubiquitin-specific-processing protease OTUB1. It is a deubiquitylase (DUB)/ubiquitin thioesterase (EC 3.4.19.12) that can specifically remove 'Lys-48'-linked conjugated ubiquitin from protein substrates. It is also capable of cleaving NEDD8 (neural-precursor-cell-expressed developmentally down-regulated 8), but not SUMO (small ubiquitin-related modifier) 1/2/3 and ISG15 (interferon-stimulated gene 15) conjugates. In addition, OTUB1 inhibits the DNA damage response independently of its catalytic activity by blocking ubiquitin transfer onto protein substrates via sequestration of E2 ubiquitin-conjugating enzymes. It also regulates many cancer-associated signaling pathways including MAPK, ERa, epithelial-mesenchymal transition (EMT), RHOa, mTORC1, FOXM1 and P53 to promote tumor cell survival, proliferation, invasiveness and therapeutic resistance. OTUB1 belongs to the OTU family of cysteine proteases that use a conserved cysteine, histidine, and an aspartate, as the catalytic triad. It is classified as a family C65 cysteine protease by MEROPS.


Pssm-ID: 438600  Cd Length: 224  Bit Score: 54.11  E-value: 5.56e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002239142 184 DNSFQQpevglRLKYLSHHYSEFRPVHRDEECFYRSFIFSYLEQVVDsigtREEDrlLAAVRALATKAENLQWASEFSQK 263
Cdd:cd22763    19 DPIYQA-----KIKDLKKKYSYIRRTRPDGNCFYRAFGFAYLESLLD----DPEE--LQRFKEVAAKSKDELVSLGFPSF 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002239142 264 -----HKAFERLIEKIKGWKRMQEhpisiirgkILEFFSSYDTTDDIFAFLRLVaaTWMCTRiwnyewcaTNCGENQN-- 336
Cdd:cd22763    88 tiedfHDTFMEVLEKVEKGTSVEE---------LLEIFNDQGTSDYLVVYLRLL--TSGYLQ--------KEADFFQNfi 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002239142 337 -----LEDWCSK------------HVIaprvyatsaavkACAEALRVTVQVENVH--DGTCESTHYIVRG-APCVTLLRI 396
Cdd:cd22763   149 eggrsVKEFCSQevepmykesdhiHII------------ALTSALGVSVRVEYMDrgEGGTVNPHDFPEGsEPRIHLLYR 216


                  ....*...
gi 1002239142 397 ESHYDIIY 404
Cdd:cd22763   217 PGHYDILY 224
OTU_RDRP-like cd22792
OTU (ovarian tumor) domain of the potexviruses/carlaviruses RNA replication protein family; ...
 348-405 5.26e-03

OTU (ovarian tumor) domain of the potexviruses/carlaviruses RNA replication protein family; RNA replication polyprotein (RDRP) is a viral homolog of ovarian tumor protease (vOTU), which displays RNA helicase (EC 3.6.4.13), RNA-directed RNA polymerase (EC 2.7.7.48), viral methyltransferase, Fe(2+) 2-oxoglutarate dioxygenase and protease activities. The central part of this protein possibly functions as an ATP-binding helicase. It is an RNA-directed RNA polymerase involved in viral RNA replication. It also acts as a thiol protease that cleaves the polyprotein. This subfamily belongs to the OTU family of cysteine proteases that use a conserved cysteine, histidine, and an aspartate, as the catalytic triad.


Pssm-ID: 438613 [Multi-domain]  Cd Length: 108  Bit Score: 37.20  E-value: 5.26e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1002239142 348 PRVYATSAAVKACAEALRVTVQVENVHDGTCesTHYIVRGAPCVTLLRIES-HYDIIYP 405
Cdd:cd22792    51 PGVYAEDEAIAAAAKLFGVNICVHDPDEGVL--YTFTPNESSKSIHLLLENeHFEPLVP 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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