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Conserved domains on  [gi|1002224425|ref|XP_015626282|]
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probable peptide/nitrate transporter At3g43790 isoform X2 [Oryza sativa Japonica Group]

Protein Classification

MFS transporter( domain architecture ID 13023689)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
PubMed:  26758938|26098515|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 13-353 5.94e-38

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 140.41  E-value: 5.94e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  13 GASYMFGRALSSVIWGIVADKYGRKPIIIITLISIIIFNTLFGLSSSYWMALTSRGLLGLMCGILGPIKAYATEVCRKEH 92
Cdd:cd17330    40 QSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEE 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  93 GHLGLSLVSSSRGIGLIVGPAIGGYLAQPadkypsifseksifgrFPYFLPCLCISLLAIVALLASFWLPetlhkhtqdm 172
Cdd:cd17330   120 RAKAFGIISAAFGLGFILGPALGGFLSTP----------------YGYALPFLVAAALALLNLVLVLFFL---------- 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425 173 vledsisveeglsgptaeensagclnlftnWPLMSAIIAYCIFSLQDVAYAEVFSLWAVSDrkyggLSFSSQDVGSVLAF 252
Cdd:cd17330   174 ------------------------------PPLRRLLLVYFLIALAFAGLESVFSLFLKDR-----FGFSPSQIGLLLAL 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425 253 SGLFLLVFQILVYPSVAKSVEPITLVRIVAILTIPLLSSYPFMAGLSgsilqlIVNCASFLKNAFAVTTITVFNILMNDA 332
Cdd:cd17330   219 VGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVP------LLVLAAAILAFGTGIVFPALSALLSKS 292

                         330       340
                  ....*....|....*....|.
gi 1002224425 333 VAQDVRASANGVAVTLMSIFK 353
Cdd:cd17330   293 VPSKEQGKAQGIIQSLQSLAR 313
 
Name Accession Description Interval E-value
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 13-353 5.94e-38

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 140.41  E-value: 5.94e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  13 GASYMFGRALSSVIWGIVADKYGRKPIIIITLISIIIFNTLFGLSSSYWMALTSRGLLGLMCGILGPIKAYATEVCRKEH 92
Cdd:cd17330    40 QSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEE 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  93 GHLGLSLVSSSRGIGLIVGPAIGGYLAQPadkypsifseksifgrFPYFLPCLCISLLAIVALLASFWLPetlhkhtqdm 172
Cdd:cd17330   120 RAKAFGIISAAFGLGFILGPALGGFLSTP----------------YGYALPFLVAAALALLNLVLVLFFL---------- 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425 173 vledsisveeglsgptaeensagclnlftnWPLMSAIIAYCIFSLQDVAYAEVFSLWAVSDrkyggLSFSSQDVGSVLAF 252
Cdd:cd17330   174 ------------------------------PPLRRLLLVYFLIALAFAGLESVFSLFLKDR-----FGFSPSQIGLLLAL 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425 253 SGLFLLVFQILVYPSVAKSVEPITLVRIVAILTIPLLSSYPFMAGLSgsilqlIVNCASFLKNAFAVTTITVFNILMNDA 332
Cdd:cd17330   219 VGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVP------LLVLAAAILAFGTGIVFPALSALLSKS 292

                         330       340
                  ....*....|....*....|.
gi 1002224425 333 VAQDVRASANGVAVTLMSIFK 353
Cdd:cd17330   293 VPSKEQGKAQGIIQSLQSLAR 313
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
14-351 1.16e-15

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 77.71  E-value: 1.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  14 ASYMFGRALSSVIWGIVADKYGRKPIIIITLISIIIFNTLFGLSSSYWMALTSRGLLGLMCGILGPIK-AYATEVCRKEH 92
Cdd:COG2814    52 TAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAAlALIADLVPPER 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  93 GHLGLSLVSSSRGIGLIVGPAIGGYLAQpadkypsIFSEKSIFGrfpyflpcLCISLLAIVALLASFWLPETLHkhtqdm 172
Cdd:COG2814   132 RGRALGLLGAGLGLGPALGPLLGGLLAD-------LFGWRWVFL--------VNAVLALLALLLLLRLLPESRP------ 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425 173 vledsisveeglsgPTAEENSAGCLNLFTNWPLMSAIIAYCIFSLQDVAYAEVFSLWAVSdrkygGLSFSSQDVGSVLAF 252
Cdd:COG2814   191 --------------AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQE-----VLGLSASAAGLLLAL 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425 253 SGLFLLVFQILVYPSVAKSVEPITLVRIVAILTIPLLssypfMAGLSGSILQLIVncASFLKNAFAVTTITVFNILMNDA 332
Cdd:COG2814   252 FGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLL-----LLALAGSLWLLLL--ALFLLGFGFGLLFPLLQALVAEL 324

                         330
                  ....*....|....*....
gi 1002224425 333 VAQDVRASANGVAVTLMSI 351
Cdd:COG2814   325 APPEARGRASGLYNSAFFL 343
MFS_1 pfam07690
Major Facilitator Superfamily;
14-351 2.35e-11

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 64.75  E-value: 2.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  14 ASYMFGRALSSVIWGIVADKYGRKPIIIITLISIIIFNTLFGLSSSYWMALTSRGLLGLMCGILGP-IKAYATEVCRKEH 92
Cdd:pfam07690  39 TLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPaALALIADWFPPEE 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  93 GHLGLSLVSSSRGIGLIVGPAIGGYLAqpadkypSIFSEKSIFGrfpyflpcLCISLLAIVALLASFWLPETLHKHTqdm 172
Cdd:pfam07690 119 RGRALGLVSAGFGLGAALGPLLGGLLA-------SLFGWRAAFL--------ILAILSLLAAVLLLLPRPPPESKRP--- 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425 173 vledsisveegLSGPTAEENSAGCLNLFTNWPLMSAIIAYCIFSLQDVAYAEVFSLWAVSdrkyggLSFSSQDVGSVLAF 252
Cdd:pfam07690 181 -----------KPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEV------LGLSALLAGLLLGL 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425 253 SGLFLLVFQILVyPSVAKSVEPITLVRIVAILTIPLLSSYPFMAGLSGSILQLIvncASFLKNAFAVTTITVFNILMNDA 332
Cdd:pfam07690 244 GGLLGAIGRLLL-GRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLL---ALLLLGFGFGLVFPALNALVSDL 319

                         330
                  ....*....|....*....
gi 1002224425 333 VAQDVRASANGVAVTLMSI 351
Cdd:pfam07690 320 APKEERGTASGLYNTAGSL 338
2_A_01_02 TIGR00880
Multidrug resistance protein;
14-164 3.69e-06

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 46.10  E-value: 3.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  14 ASYMFGRALSSVIWGIVADKYGRKPIIIITLISIIIFNTLFGLSSSYWMALTSRGLLGLMCGILGPI-KAYATEVCRKEH 92
Cdd:TIGR00880   5 AGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAgAALIADIYPPEE 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002224425  93 GHLGLSLVSSSRGIGLIVGPAIGGYLAQpADKYPSIFseksifgrfpYFLPCLCIsllaIVALLASFWLPET 164
Cdd:TIGR00880  85 RGVALGLMSAGIALGPLLGPPLGGVLAQ-FLGWRAPF----------LFLAILAL----AAFILLAFLLPET 141
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
21-152 1.44e-05

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 46.84  E-value: 1.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  21 ALSSVIWGIVADKYGRKPIIIITLISIIIFNTLFGLSSSYWMALTSRGLLGLMCGILGPIKAY-ATEVCRKEHGhLGLSL 99
Cdd:PRK09874   68 AIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALiATQVPRNKSG-WALGT 146

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1002224425 100 VSSSRGIGLIVGPAIGGYLAQPADKYPSIFSEKSIfgrfpyFLPCLCISLLAI 152
Cdd:PRK09874  147 LSTGGVSGALLGPLAGGLLADSYGLRPVFFITASV------LFLCFLVTLFCI 193
 
Name Accession Description Interval E-value
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 13-353 5.94e-38

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 140.41  E-value: 5.94e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  13 GASYMFGRALSSVIWGIVADKYGRKPIIIITLISIIIFNTLFGLSSSYWMALTSRGLLGLMCGILGPIKAYATEVCRKEH 92
Cdd:cd17330    40 QSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEE 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  93 GHLGLSLVSSSRGIGLIVGPAIGGYLAQPadkypsifseksifgrFPYFLPCLCISLLAIVALLASFWLPetlhkhtqdm 172
Cdd:cd17330   120 RAKAFGIISAAFGLGFILGPALGGFLSTP----------------YGYALPFLVAAALALLNLVLVLFFL---------- 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425 173 vledsisveeglsgptaeensagclnlftnWPLMSAIIAYCIFSLQDVAYAEVFSLWAVSDrkyggLSFSSQDVGSVLAF 252
Cdd:cd17330   174 ------------------------------PPLRRLLLVYFLIALAFAGLESVFSLFLKDR-----FGFSPSQIGLLLAL 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425 253 SGLFLLVFQILVYPSVAKSVEPITLVRIVAILTIPLLSSYPFMAGLSgsilqlIVNCASFLKNAFAVTTITVFNILMNDA 332
Cdd:cd17330   219 VGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVP------LLVLAAAILAFGTGIVFPALSALLSKS 292

                         330       340
                  ....*....|....*....|.
gi 1002224425 333 VAQDVRASANGVAVTLMSIFK 353
Cdd:cd17330   293 VPSKEQGKAQGIIQSLQSLAR 313
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
14-351 1.16e-15

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 77.71  E-value: 1.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  14 ASYMFGRALSSVIWGIVADKYGRKPIIIITLISIIIFNTLFGLSSSYWMALTSRGLLGLMCGILGPIK-AYATEVCRKEH 92
Cdd:COG2814    52 TAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAAlALIADLVPPER 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  93 GHLGLSLVSSSRGIGLIVGPAIGGYLAQpadkypsIFSEKSIFGrfpyflpcLCISLLAIVALLASFWLPETLHkhtqdm 172
Cdd:COG2814   132 RGRALGLLGAGLGLGPALGPLLGGLLAD-------LFGWRWVFL--------VNAVLALLALLLLLRLLPESRP------ 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425 173 vledsisveeglsgPTAEENSAGCLNLFTNWPLMSAIIAYCIFSLQDVAYAEVFSLWAVSdrkygGLSFSSQDVGSVLAF 252
Cdd:COG2814   191 --------------AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQE-----VLGLSASAAGLLLAL 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425 253 SGLFLLVFQILVYPSVAKSVEPITLVRIVAILTIPLLssypfMAGLSGSILQLIVncASFLKNAFAVTTITVFNILMNDA 332
Cdd:COG2814   252 FGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLL-----LLALAGSLWLLLL--ALFLLGFGFGLLFPLLQALVAEL 324

                         330
                  ....*....|....*....
gi 1002224425 333 VAQDVRASANGVAVTLMSI 351
Cdd:COG2814   325 APPEARGRASGLYNSAFFL 343
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 14-351 7.51e-14

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 72.22  E-value: 7.51e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  14 ASYMFGRALSSVIWGIVADKYGRKPIIIITLISIIIFNTLFGLSSSYWMALTSRGLLGLMCGILGPIK-AYATEVCRKEH 92
Cdd:cd17325    38 AAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAmALIADIAPPEE 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  93 GHLGLSLVSSSRGIGLIVGPAIGGYLAQpadkypsifsekSIFGRFPYFlpcLCISLLAIVALLASFWLPETLHKHTQDM 172
Cdd:cd17325   118 RGRAMGIFSSAIGLGFLIGPLLGGLLAD------------ALGYRAPFL---VCAALALLALVLALLLLPEPRPPPNKRA 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425 173 VLEDSISVEEGLsgptaeensagclnLFTNWPLMSAIIAYCIFSLQDVAYAEVFSLWAVSDrkyggLSFSSQDVGSVLAF 252
Cdd:cd17325   183 VSAARLRSGLRL--------------LLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAEL-----GGLSPAQIGLLFGA 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425 253 SGLFLLVFQILVYPSVAK--SVEPITLVRIVAILTIPLLssypfmaGLSGSILQLIVNCA-SFLKNAFAVTTITVfniLM 329
Cdd:cd17325   244 QGLASALSQPPAGKLSDRigRKPLILIGLLLSAVALLLL-------PLATSFWLLLLLLAlLGLGLGLVFPATLA---LL 313

                         330       340
                  ....*....|....*....|..
gi 1002224425 330 NDAVAQDVRASANGVAVTLMSI 351
Cdd:cd17325   314 ADIVPPEGRGTAMGLFNTAFSL 335
MFS_1 pfam07690
Major Facilitator Superfamily;
14-351 2.35e-11

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 64.75  E-value: 2.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  14 ASYMFGRALSSVIWGIVADKYGRKPIIIITLISIIIFNTLFGLSSSYWMALTSRGLLGLMCGILGP-IKAYATEVCRKEH 92
Cdd:pfam07690  39 TLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPaALALIADWFPPEE 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  93 GHLGLSLVSSSRGIGLIVGPAIGGYLAqpadkypSIFSEKSIFGrfpyflpcLCISLLAIVALLASFWLPETLHKHTqdm 172
Cdd:pfam07690 119 RGRALGLVSAGFGLGAALGPLLGGLLA-------SLFGWRAAFL--------ILAILSLLAAVLLLLPRPPPESKRP--- 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425 173 vledsisveegLSGPTAEENSAGCLNLFTNWPLMSAIIAYCIFSLQDVAYAEVFSLWAVSdrkyggLSFSSQDVGSVLAF 252
Cdd:pfam07690 181 -----------KPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEV------LGLSALLAGLLLGL 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425 253 SGLFLLVFQILVyPSVAKSVEPITLVRIVAILTIPLLSSYPFMAGLSGSILQLIvncASFLKNAFAVTTITVFNILMNDA 332
Cdd:pfam07690 244 GGLLGAIGRLLL-GRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLL---ALLLLGFGFGLVFPALNALVSDL 319

                         330
                  ....*....|....*....
gi 1002224425 333 VAQDVRASANGVAVTLMSI 351
Cdd:pfam07690 320 APKEERGTASGLYNTAGSL 338
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 14-352 1.73e-08

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 55.90  E-value: 1.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  14 ASYMFGRALSSVIWGIVADKYGRKPIIIITLISIIIFNTLFGLSSSYWMALTSRGLLGLMCGILGPI-KAYATEVCRKEH 92
Cdd:cd06174    38 ALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAvLALIADLFPERE 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  93 GHLGLSLVSSSRGIGLIVGPAIGGYLAQpadkypsifseksiFGRFPYFLPCLCISLLAIVALLASFWLPETLHKHTQdm 172
Cdd:cd06174   118 RGRALGLLQAFGSVGGILGPLLGGILAS--------------SLGFGWRAVFLIAAALALLAAILLLLVVPDPPESAR-- 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425 173 vledsisveEGLSGPTAEENSAGCLNLFTNWPLMSAIIAYcifSLQDVAYAEVFSLWAVSDRKYGGLSFSSqdVGSVLAF 252
Cdd:cd06174   182 ---------AKNEEASSKSVLKLLKRVLKNPGLWLLLLAI---FLVNLAYYSFSTLLPLFLLDLGGLSVAV--AGLLLSL 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425 253 SGLFLLVFQILVYPSVAKSVEPITLVRIVAILTIPLLSSYPFMAGLSGSILQLIVNCasflknAFAVTTITVFNILMNDA 332
Cdd:cd06174   248 FGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLG------FGLGGLLPLSFALIAEL 321

                         330       340
                  ....*....|....*....|
gi 1002224425 333 VAQDVRASANGVAVTLMSIF 352
Cdd:cd06174   322 FPPEIRGTAFGLLNTFGFLG 341
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 3-167 4.00e-08

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 54.97  E-value: 4.00e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425   3 VLSGELViceGASYMFGRALSSVIWGIVADKYGRKPIIIITLISIIIFNTLFGLSSSYWMALTSRGLLGLMCGILGPIKA 82
Cdd:cd17389    63 VLFGGLI---GSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTA 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  83 YATEVCRKEHGHLGLSLVSSSRGIGLIVGPAIGGYLAQPADKYPSIFSEKSifgrfpyflPCLCISLLAIVALLASFWLP 162
Cdd:cd17389   140 IVADVTSPKKRSKGMALIGVAFSLGFIIGPMIGAYFASFTRSLGEVFFSMP---------ALFALVLALADLLFIFFFLP 210


                  ....*
gi 1002224425 163 ETLHK 167
Cdd:cd17389   211 ETLPS 215
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 14-264 8.84e-08

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 53.28  E-value: 8.84e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  14 ASYMFGRALSSVIWGIVADKYGRKPIIIITLISIIIFNTLFGLSSSYWMALTSRGLLGLMCGILGPI-KAYATEVCRKEH 92
Cdd:COG0477    56 SAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGaLALIAELFPARE 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  93 GHLGLSLVSSSRGIGLIVGPAIGGYLAQpadkypsIFSEKSIFgrfpyflpcLCISLLAIVALLASFWLPETLHKHTQDM 172
Cdd:COG0477   136 RGRALGLWGAAIGLGLALGPLLGGLLVA-------ALGWRWIF---------LINAPLGLLALVLRLRLPESRGLLLALL 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425 173 VLEDSISVEEGLSGPTAEENSAGCLNLFTNWPLMSAIIAYCIFSLQDVAYAEVFSLWAVSDRKYGGLSFSSQDVGSVLAF 252
Cdd:COG0477   200 ALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALL 279

                         250
                  ....*....|..
gi 1002224425 253 SGLFLLVFQILV 264
Cdd:COG0477   280 LLLLLLLLLLLL 291
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
13-161 1.10e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 53.34  E-value: 1.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  13 GASYMFGRALSSVIWGIVADKYGRKPIIIITLISIIIFNTLFGLSSSYWMALTSRGLLGLMCGILGP-IKAYATEVCRKE 91
Cdd:COG2271    51 ASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPaALKLIAEWFPPK 130

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  92 HGHLGLSLVSSSRGIGLIVGPAIGGYLAQpadkypsifseksifgRFPYFLPCLCISLLAIVALLASFWL 161
Cdd:COG2271   131 ERGRALGIFNAGGPLGGALAPPLLGWLLA----------------AFGWRAAFLILGLPGLLLALLRFWL 184
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 14-401 6.73e-07

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 51.10  E-value: 6.73e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  14 ASYMFGRALSSVIWGIVADKYGRKPIIIITLISIIIFNTLFGLSSSYWMALTSRGLLGLMCGILGPIKAYATEVCRKEHG 93
Cdd:cd17388    45 ALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQR 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  94 HLGLSLVSSSRGIGLIVGPAIGGYLAQPADKYPsifseksifgrfpyFLPCLCISLLAivALLASFWLPETLHKhtqdmv 173
Cdd:cd17388   125 ARNFGLLGAAFGLGFIAGPALGGLLGEISPRAP--------------FLVAAGLNGLN--FLLGLFVLPESLPP------ 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425 174 ledsisvEEGLSGPTAEENSAGCLNLFTNWPLMSAIIAycIFSLQDVAYAEVFSLWAVsdrkYGGLSF--SSQDVGSVLA 251
Cdd:cd17388   183 -------ERRRAFRWRRANPFGSLRWLTGFPGLLGLLA--VFFLIQLIGQVPATTWVL----FTEDRFdwSPTMVGLSLA 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425 252 FSGLFLLVFQ-ILVYPSVAKSVEPITLvrivailtipllssypfmaglsgsILQLIVNCASFLKNAFAVTTITVFNIL-- 328
Cdd:cd17388   250 VFGLLHALFQaFVTGPIAKRLGEKRAI------------------------LLGLAADALGFLLLAFATQGWMVFPILil 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425 329 --------------MNDAVAQDVRASANGVAVTLMSIFKAIAPAIAGAIFAWaqrrqTASFLPGdhLVFFMLNVFTVIGL 394
Cdd:cd17388   306 lalggiagpalqglLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAA-----SPATWPG--LAWIIGAALYLICL 378


                  ....*..
gi 1002224425 395 VSTFRPF 401
Cdd:cd17388   379 VLAYRFF 385
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 15-170 1.21e-06

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 50.26  E-value: 1.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  15 SYMFGRALSSVIWGIVADKYGRKPIIIITLISIIIFNTLFGLSSSYWMALTSRGLLGLMCGILGP-----IKAYATEVCR 89
Cdd:cd17474    42 AFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPlaltlIGDLFEGGER 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  90 KEhghlGLSLVSSSRGIGLIVGPAIGGYLAqpadkypsifsekSIFGRFPYFLPCLCIsllaIVALLASFWLPETLHKHT 169
Cdd:cd17474   122 AK----AMGLYEAALGLGIAVGPLLGGLLA-------------AISWRYPFFLLAALI----PVAFLAILFLLPEPKEKA 180


                  .
gi 1002224425 170 Q 170
Cdd:cd17474   181 K 181
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 18-307 2.79e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 49.15  E-value: 2.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  18 FGRALSSVIWGIVADKYGRKPIIIITLISIIIFNTLFGLSSSYWMALTSRGLLGLMCGILGP-IKAYATEVCRKEHGHLG 96
Cdd:cd17329    46 VAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPaSEAMIADVTTPENRTRA 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  97 LSLVSSSRGIGLIVGPAIGGYLaqpadkypsifseksiFGRFPYFLPCLCISLLAIVALLASFWLPETLHKHTQdmvled 176
Cdd:cd17329   126 FSLLYWAINLGVAIGPLLGGLL----------------LLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRA------ 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425 177 sisveeglsgPTAEENSAGCLNLFTNWPLMSAIIAYCIFSLQDVAYAEVFSLWAVSDrkyggLSFSSQDVGSVLAFSGLF 256
Cdd:cd17329   184 ----------AEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEI-----LGLGESLLGLLLALNALL 248

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1002224425 257 LLVFQILvypsVAKSVEPITLVRIVAILTIpLLSSYPFMAGLSGSILQLIV 307
Cdd:cd17329   249 IVLLQFP----VARLVERFRLRKILMIGIL-LFAIGFAVLAFANTLAVLIL 294
2_A_01_02 TIGR00880
Multidrug resistance protein;
14-164 3.69e-06

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 46.10  E-value: 3.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  14 ASYMFGRALSSVIWGIVADKYGRKPIIIITLISIIIFNTLFGLSSSYWMALTSRGLLGLMCGILGPI-KAYATEVCRKEH 92
Cdd:TIGR00880   5 AGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAgAALIADIYPPEE 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002224425  93 GHLGLSLVSSSRGIGLIVGPAIGGYLAQpADKYPSIFseksifgrfpYFLPCLCIsllaIVALLASFWLPET 164
Cdd:TIGR00880  85 RGVALGLMSAGIALGPLLGPPLGGVLAQ-FLGWRAPF----------LFLAILAL----AAFILLAFLLPET 141
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 14-170 4.10e-06

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 48.34  E-value: 4.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  14 ASYMFGRALSSVIWGIVADKYGRKPIIIITLISIIIFNTLFGLSSSYWMALTSR---GLLGLMCGILGPikAYATEVCRK 90
Cdd:cd17320    41 SAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARflqGLGAAAGSVVAR--AIVRDLYSG 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  91 EHGHLGLSLVSSSRGIGLIVGPAIGGYLAQPADkYPSIFseksifgrfpyflpcLCISLLAIVALLAS-FWLPETLHKHT 169
Cdd:cd17320   119 AELAKIFSLLMMILAIAPALAPLLGGLLLLFFG-WRAIF---------------VFLALLGLLLLLLVlLFLPETLPEEK 182


                  .
gi 1002224425 170 Q 170
Cdd:cd17320   183 R 183
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 26-350 4.16e-06

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 48.37  E-value: 4.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  26 IWGIVADKYGRKPIIIITLISIIIFNTLFGLSSSYWMALTSRGLLGLMCGILGPiKAYATEVCRKEH-----GHLGLSLv 100
Cdd:cd17331    54 LFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRLPSVFMHAMQAA-QMVVTDLTDPGEraaalGRLGLSY- 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425 101 sssrGIGLIVGPAIGGYLAqpadkypsifseksifGRFPYFLPCLCISLLAIVALLASFWLPETLHKHTQDmvledsiSV 180
Cdd:cd17331   132 ----GIGMVVGSFLGGLLT----------------KKFGEQAAALVAAVGSLLSIVLVILLIPSNTKSKRE-------KE 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425 181 EEGLSGPTAEENSAGCLNLFTN---WPLMSAIIaycIFSLQDVAYAEVFSLWAVsDRkyggLSFSSQDVGSVLAFSGLFL 257
Cdd:cd17331   185 AKESASPPSVFNLKEILRLLRLpgvAFLLLVKL---LSGLPIGMFQSMFSLVAM-DF----FGLTPEENGYLMSYAGVLG 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425 258 LVFQILVYPSVAKSVEPITLVRIVAILtipLLSSYPFMAGLSGSILQLIVncasFLKNAFAVTTI-TVFNILMNDAVAQD 336
Cdd:cd17331   257 MVVQGLLVGPLTKRFGERSLLKLSVAL---LAIGYLLLAFVTTVWQLLVL----LLPLVIGGSVLyTVITSLLTKAVPPE 329

                         330
                  ....*....|....
gi 1002224425 337 VRASANGVAVTLMS 350
Cdd:cd17331   330 DTGTALGLSHALFS 343
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 23-163 5.30e-06

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 47.99  E-value: 5.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  23 SSVIWGIVADKYGRKPIIIITLISIIIFNTLFGLSSSYWMALTSRGLLGLMCGILGPIKAYATEVCRKEHGHLGLSLVSS 102
Cdd:cd17390    47 SSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNA 126

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002224425 103 SRGIGLIVGPAIGGYLAQPADKypsifseksifgrfpYFLPCLCISLLAIV-ALLASFWLPE 163
Cdd:cd17390   127 ASSLGFILGPVVGGHLAETDGG---------------FYYVALLCSAIFILnAGLVWFLLSK 173
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 16-168 1.24e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 47.16  E-value: 1.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  16 YMFGRALSSVIWGIVADKYGRKPIIIITLISIIIFNTLFGLSSSYWMALTSRGLLGLMCGILGPIK-AYATEVCRKEHGH 94
Cdd:cd17324    43 YALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAaAYAADLVPPEKRG 122

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1002224425  95 LGLSLVSSSRGIGLIVGPAIGGYLAQpadkypsIFSEKSIFgrfpyflpcLCISLLAIVALLA-SFWLPETLHKH 168
Cdd:cd17324   123 RAIGLVFSGLTLGLVLGRPLGGLLGQ-------LLGWRAAF---------LAIAVLALLAALLlWRLLPSLPPKK 181
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
21-152 1.44e-05

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 46.84  E-value: 1.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  21 ALSSVIWGIVADKYGRKPIIIITLISIIIFNTLFGLSSSYWMALTSRGLLGLMCGILGPIKAY-ATEVCRKEHGhLGLSL 99
Cdd:PRK09874   68 AIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALiATQVPRNKSG-WALGT 146

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1002224425 100 VSSSRGIGLIVGPAIGGYLAQPADKYPSIFSEKSIfgrfpyFLPCLCISLLAI 152
Cdd:PRK09874  147 LSTGGVSGALLGPLAGGLLADSYGLRPVFFITASV------LFLCFLVTLFCI 193
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 21-163 2.71e-05

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 46.10  E-value: 2.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  21 ALSSVIWGIVADKYGRKPIIIITLISIIIFNTLFGLSSSYWMALTSRGLLGLMCGILGPIKAYATEVCRKEHGHLGLSLV 100
Cdd:cd17391    50 AIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGYVPNATALIASQTPKEKSGWALGTL 129

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1002224425 101 SSSRGIGLIVGPAIGGYLAQpadkypsifseksIFGRFPYFLpcLCISLLAIVALLASFWLPE 163
Cdd:cd17391   130 STGVVAGTLIGPLLGGFLAD-------------LFGIRNVFF--ITGGLLFLAFLLTLFFVKE 177
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 13-118 5.85e-05

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 44.90  E-value: 5.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  13 GASYMFGRALSSVIWGIVADKYGRKPIIIITLISIIIFNTLFGLSSSYWMALTSRGLLGL-MCGILGPIKAYATEVCRKE 91
Cdd:cd17316    42 FAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIgIGGEYPGASTYVAEFAPSK 121

                          90       100
                  ....*....|....*....|....*..
gi 1002224425  92 HGHLGLSLVSSSRGIGLIVGPAIGGYL 118
Cdd:cd17316   122 RRGFALGLLQSGWALGALLAALVASLL 148
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 14-162 7.00e-05

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 44.49  E-value: 7.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  14 ASYMFGRALSSVIWGIVADKYGRKPIIIITLISIIIFNTLFGLSSSYWMALTSRGLLGLMC-GILGPIKAYATEVCRKEH 92
Cdd:cd17317    32 TIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSaGIFTVGFVLGMEIVGPKY 111

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  93 GHLGLSLVSSSRGIGLIVGPAIGgylaqpadkypsifsekSIFGRFPYFLpcLCISLLAIVALLASFWLP 162
Cdd:cd17317   112 RSFVGILFGLFWALGYMLLALLA-----------------YLIRDWRWLQ--LAISLPGLLFLLLLWWLP 162
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
18-171 3.04e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 42.53  E-value: 3.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  18 FGRALSSVIWGIVADKYGRKPIIIITLISIIIFNTLFGLSSSYWMALTSRGLLGLMCGILGP-IKAYATEVCRKEHGHLg 96
Cdd:COG0738    54 LGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVaANPYVAALGPETAASR- 132

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1002224425  97 LSLVSSSRGIGLIVGPAIGGYLaqpadkypsIFSEKSIFGRFPYFLpcLCISLLAIVALLASFWLPETLHKHTQD 171
Cdd:COG0738   133 LNLLHAFFSLGALLGPLLGGLL---------ILLGLSLSWHLPYLI--LAVLLLLLALLFLRSKLPEIEEEEEEA 196
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 17-165 4.88e-04

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 41.96  E-value: 4.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  17 MFGRALSSVIWGIVADKYGRKPIIIITLISIIIFNTLFGLSSSYWMALTSRGLLGLMCGILGPI-KAYATEVCRKEHGHL 95
Cdd:TIGR00895  62 LIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNlNALVSEYAPKRFRGT 141

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  96 GLSLVSSSRGIGLIVGPAIGGYLAqPADKYPSIFsekSIFGRFPyflpclcisllAIVALLASFWLPETL 165
Cdd:TIGR00895 142 AVGLMFCGYPIGAAVGGFLAGWLI-PVFGWRSLF---YVGGIAP-----------LLLLLLLMRFLPESI 196
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 16-159 8.88e-04

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 41.02  E-value: 8.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  16 YMFGRALSSVIWGIVADKYGRKPIIIITLISIIIFNTLFGLSSSYWMALTSRGLLGLM-CGILGPIKAYATEVCRKEHGH 94
Cdd:cd17323    43 FVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFgSSPLAIGAGTIADLFTPEERG 122

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1002224425  95 LGLSLVSSSRGIGLIVGPAIGGYLAQPADkYPSIFSEKSIFGRFPYFLPCLCISLLAIVALLASF 159
Cdd:cd17323   123 KAMGVYSLGPLLGPALGPIIGGFITQSLG-WRWIFWFLAIISGFCLILIFLFLPIVLLLGLYVGL 186
Sugar_tr pfam00083
Sugar (and other) transporter;
14-164 9.20e-04

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 41.10  E-value: 9.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  14 ASYMFGRALSSVIWGIVADKYGRKPIIIITLISIIIFNTLFGLS---SSYWMALTSRGLLGLMCGILGPI-KAYATEVCR 89
Cdd:pfam00083  53 SIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIGVGGASVLaPMYISEIAP 132

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1002224425  90 KEH-GHLGlSLVSSSRGIGLIVGPAIGgylaqpadkYPSIFSEKSIFGRFPYFLpclcISLLAIVALLASFWLPET 164
Cdd:pfam00083 133 KKLrGALG-SLYQLAITFGILLAYIFG---------LGLNKTSNSDGWRIPLGL----QLVPALLLIIGLLFLPES 194
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 14-72 2.61e-03

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 40.00  E-value: 2.61e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1002224425  14 ASYMFGRALSSVIWGIVADKYGRKPIIIITLISIIIFNTLFGLSSSYWMALTSRGLLGL 72
Cdd:TIGR00898 134 SCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGM 192
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 15-120 6.72e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 38.31  E-value: 6.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  15 SYMFGRALSSVIWGIVADKYGRKPIIIITLISIIIFNTLFGLSSSYWMALTSRGLLGLMCGILGPIK-AYATEVCRKEHG 93
Cdd:cd17321    39 AYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASlALIAATFPGERR 118

                          90       100
                  ....*....|....*....|....*..
gi 1002224425  94 HLGLSLVSSSRGIGLIVGPAIGGYLAQ 120
Cdd:cd17321   119 GRALGLWGAVVGIGAALGPLLGGLLLE 145
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 14-170 8.57e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 37.96  E-value: 8.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  14 ASYMFGRALSSVIWGIVADKYGRKPIIIITLISIIIFNTLFGLSSSYWMALTSRGLLGLMCGILGP-IKAYATEVCRKEH 92
Cdd:cd17489    38 GLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTaAATLVADIIPPSR 117

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1002224425  93 GHLGLSLVSSSRGIGLIVGPAIGGYLAQPADkYPSIFseksifgrfpyflpcLCISLLAIVALLASFWLPETLHKHTQ 170
Cdd:cd17489   118 RGEGIGYYGLATTLAMALGPALGLFLYQHLG-FAVLF---------------IVAAVLALLALLLVFLVKDPPPVAAE 179
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 13-120 9.32e-03

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 37.93  E-value: 9.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224425  13 GASYMFGRALSSVIWGIVADKYGRKPIIIITLISIIIFNTLFGLSSSYWMALTSRGLLGLMCGILGPIK--AYATEVCRK 90
Cdd:cd17502    36 GTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAfiIIADLVPPR 115

                          90       100       110
                  ....*....|....*....|....*....|
gi 1002224425  91 EHGHLgLSLVSSSRGIGLIVGPAIGGYLAQ 120
Cdd:cd17502   116 ERGKY-QGYIGAVFGIASVAGPLIGGAFTD 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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